PREFIX owl: <http://www.w3.org/2002/07/owl#>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
PREFIX cito: <http://purl.org/spar/cito/>
PREFIX dc: <http://purl.org/dc/elements/1.1/>
PREFIX dct: <http://purl.org/dc/terms/>
PREFIX linkml: <https://w3id.org/linkml/>
PREFIX protege: <http://protege.stanford.edu/plugins/owl/protege#>
PREFIX schema: <http://schema.org/>
PREFIX sio: <http://semanticscience.org/resource/>
PREFIX skosvocab: <http://www.w3.org/2004/02/skos/core#>
PREFIX vann: <http://purl.org/vocab/vann/>
PREFIX xml: <http://www.w3.org/XML/1998/namespace>
PREFIX dcterms: <http://purl.org/dc/terms/>
PREFIX skos: <http://www.w3.org/2004/02/skos/core#>
PREFIX pav: <http://purl.org/pav/>
PREFIX sh: <http://www.w3.org/ns/shacl#>

<https://semanticscience.org> a owl:Ontology ;
  rdfs:comment "The Semanticscience Integrated Ontology (SIO) provides a simple, integrated ontology of types and relations for rich description of objects, processes and their attributes." ;
  dct:license <https://creativecommons.org/publicdomain/zero/1.0/> ;
  pav:version "0.1.0" ;
  vann:preferredNamespacePrefix "sio" ;
  vann:preferredNamespaceUri "http://semanticscience.org/resource/"^^xsd:anyURI ;
  sh:declare [
    sh:prefix "cito" ;
    sh:namespace "http://purl.org/spar/cito/"^^xsd:anyURI
  ] , [
    sh:prefix "dc" ;
    sh:namespace "http://purl.org/dc/elements/1.1/"^^xsd:anyURI
  ] , [
    sh:prefix "dct" ;
    sh:namespace "http://purl.org/dc/terms/"^^xsd:anyURI
  ] , [
    sh:prefix "linkml" ;
    sh:namespace "https://w3id.org/linkml/"^^xsd:anyURI
  ] , [
    sh:prefix "owl" ;
    sh:namespace "http://www.w3.org/2002/07/owl#"^^xsd:anyURI
  ] , [
    sh:prefix "protege" ;
    sh:namespace "http://protege.stanford.edu/plugins/owl/protege#"^^xsd:anyURI
  ] , [
    sh:prefix "rdf" ;
    sh:namespace "http://www.w3.org/1999/02/22-rdf-syntax-ns#"^^xsd:anyURI
  ] , [
    sh:prefix "rdfs" ;
    sh:namespace "http://www.w3.org/2000/01/rdf-schema#"^^xsd:anyURI
  ] , [
    sh:prefix "schema" ;
    sh:namespace "http://schema.org/"^^xsd:anyURI
  ] , [
    sh:prefix "sio" ;
    sh:namespace "http://semanticscience.org/resource/"^^xsd:anyURI
  ] , [
    sh:prefix "skosvocab" ;
    sh:namespace "http://www.w3.org/2004/02/skos/core#"^^xsd:anyURI
  ] , [
    sh:prefix "vann" ;
    sh:namespace "http://purl.org/vocab/vann/"^^xsd:anyURI
  ] , [
    sh:prefix "xml" ;
    sh:namespace "http://www.w3.org/XML/1998/namespace"^^xsd:anyURI
  ] , [
    sh:prefix "xsd" ;
    sh:namespace "http://www.w3.org/2001/XMLSchema#"^^xsd:anyURI
  ] .

sio:1DCartesianPoint a owl:Class ;
  rdfs:comment """A 1D cartesian point is a point whose position is specified along a single dimension using Cartesian coordinates
""" ;
  rdfs:subClassOf sio:Point .

sio:1DExtentQuantity a owl:Class ;
  rdfs:comment "A quantity that extends in single dimension." ;
  rdfs:subClassOf sio:SpatialQuantity .

sio:2DCartesianPoint a owl:Class ;
  rdfs:comment """A 2D cartesian point is a point whose position is specified along two  dimensions using Cartesian coordinates.
""" ;
  rdfs:subClassOf sio:Point .

sio:2DExtentQuantity a owl:Class ;
  rdfs:comment "A quantity that extends in two dimensions." ;
  rdfs:subClassOf sio:SpatialQuantity .

sio:3_27SpliceSite a owl:Class ;
  rdfs:comment """The 3' splice site is the terminal region of an exon that is 3' to the intron that is to be excised.
""" ;
  rdfs:subClassOf sio:SpliceSite .

sio:3_27UntranslatedRegion a owl:Class ;
  rdfs:comment """A three prime untranslated region (3'-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon. 
""" ;
  rdfs:subClassOf sio:GeneComponent .

sio:3DCartesianCoordinate a owl:Class ;
  rdfs:comment """A 3D cartesian coordinate is a coordinate that is composed of an x, y and z coordinate.
""" ;
  rdfs:subClassOf sio:CartesianCoordinate .

sio:3DCartesianPoint a owl:Class ;
  rdfs:comment """A 3D cartesian point is a point whose position is specified along three  dimensions using Cartesian coordinates.
""" ;
  rdfs:subClassOf sio:Point .

sio:3DExtentQuantity a owl:Class ;
  rdfs:comment "A quantity that extends in three dimensions." ;
  rdfs:subClassOf sio:SpatialQuantity .

sio:3DStructureModel a owl:Class ;
  rdfs:comment """A 3D structure model is a representation of the spatial arrangement of one or more chemical entities.
""" ;
  rdfs:subClassOf sio:TertiaryStructureDescriptor .

sio:5_27SpliceSite a owl:Class ;
  rdfs:comment """The 5' splice site is the terminal region of an exon that is 5' to the intron that is to be excised.
""" ;
  rdfs:subClassOf sio:SpliceSite .

sio:5_27UntranslatedRegion a owl:Class ;
  rdfs:comment """The five prime untranslated region (5' UTR) is a section of messenger RNA (mRNA) and the DNA that codes for it that starts at the +1 position (where transcription begins) and ends one nucleotide before the start codon (usually AUG) of the coding region.
""" ;
  rdfs:subClassOf sio:GeneComponent .

sio:ACollectionOfDuplicates a owl:Class ;
  rdfs:comment """a collection of duplicates is a collection composed of items that are an exact copy of other items in the collection.
""" ;
  rdfs:subClassOf sio:Collection .

sio:ACollectionOfReplicates a owl:Class ;
  rdfs:comment """a collection of replicates is a collection composed of items that are a facsimile, reproduction, or copy of other items in the collection.
""" ;
  rdfs:subClassOf sio:Collection .

sio:ALittleQuantifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QuantityModifier .

sio:Abnormal a owl:Class ;
  rdfs:comment "A quality that has a value that is outside normal or average." ;
  rdfs:subClassOf sio:Normality .

sio:Aborted a owl:Class ;
  rdfs:comment """aborted is a process status in which a started process will not complete as intended.
""" ;
  rdfs:subClassOf sio:ProcessStatus .

sio:AbstractRole a owl:Class ;
  rdfs:comment """An abstract role is a role whose basis lies in spatial/temporal or comparative relations. 
""" ;
  rdfs:subClassOf sio:Role .

sio:AbstractSection a owl:Class ;
  rdfs:comment """An abstract section is a document section that provides brief summary of a document that explains the main argument(s), topic(s) or findings.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:Academic a owl:Class ;
  rdfs:comment "An academic is an individual that participates in education and scholarship." ;
  rdfs:subClassOf sio:Person .

sio:AcademicDepartment a owl:Class ;
  rdfs:comment """An academic department is a division of a university or school faculty devoted to a particular academic discipline.
""" ;
  rdfs:subClassOf sio:AcademicOrganization .

sio:AcademicOrganization a owl:Class ;
  rdfs:comment """An academic organization is a lawfully recognized organization that confers diplomas, degrees and other forms of recognition of academic achievement.
""" ;
  rdfs:subClassOf sio:Organization .

sio:AcademicRole a owl:Class ;
  rdfs:comment "An academic role is a social role that pertains to the academic institution." ;
  rdfs:subClassOf sio:OccupationalRole .

sio:Acid a owl:Class ;
  rdfs:comment """An acid is a molecular entity in solution capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).
""" ;
  rdfs:subClassOf sio:LiquidSolutionComponent .

sio:AcidBaseReaction a owl:Class ;
  rdfs:comment "An acid-base reaction is a chemical reaction between an acid and a base." ;
  rdfs:subClassOf sio:ChemicalReaction .

sio:AcknowledgementsSection a owl:Class ;
  rdfs:comment """An acknowledgements section is a document section that identifies individuals, groups or organizations for their support in the development of the work.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:ActiniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:ActionSpecification a owl:Class ;
  rdfs:comment """An action specification is a specification composed of a sequence of instructions to achieve some objective.
""" ;
  rdfs:subClassOf sio:Specification .

sio:Activator a owl:Class ;
  rdfs:comment """A molecular activator is a molecular regulator that realizes its disposition to conformationally change a target molecule and increase its functionality.
""" ;
  rdfs:subClassOf sio:MolecularRegulator .

sio:ActivatorRole a owl:Class ;
  rdfs:comment "The role of a chemical entity that increases the rate of reaction." ;
  rdfs:subClassOf sio:RegulatorRole .

sio:ActiveIngredient a owl:Class ;
  rdfs:comment "An active ingredient is a molecular entity that exhibits biological activity." ;
  rdfs:subClassOf sio:PharmaceuticalIngredient .

sio:ActiveMovement a owl:Class ;
  rdfs:comment """active movement is the process in which an object is spatially displaced using some chemical energy.
""" ;
  rdfs:subClassOf sio:Movement .

sio:ActiveSite a owl:Class ;
  rdfs:comment """An active site is a molecular site in which a chemical event occurs (structural transformation or conformational change).
""" ;
  rdfs:subClassOf sio:MolecularSite .

sio:ActiveTransport a owl:Class ;
  rdfs:comment """active transport is the movement of a substance across a membrane against its concentration gradient (from low to high concentration) and requires chemical energy.
""" ;
  rdfs:subClassOf sio:MembraneTransport .

sio:AdditionReaction a owl:Class ;
  rdfs:comment """An addition reaction is an organic reaction where two or more molecules combine to form a larger one. Addition reactions are limited to chemical compounds that have multiply-bonded atoms:
    * Molecules with carbon-carbon double bonds or triple bonds
    * Molecules with carbon - hetero double bonds like C=O or C=N
""" ;
  rdfs:subClassOf sio:OrganicReaction .

sio:Address a owl:Class ;
  rdfs:comment """An address is a position that indicates the physical location of some entity using a social convention.
""" ;
  rdfs:subClassOf sio:PositionalIdentifier .

sio:AdministrativeRole a owl:Class ;
  rdfs:comment """An administrative role is the role of an individual that performs administrative tasks for some organization.
""" ;
  rdfs:subClassOf sio:OccupationalRole .

sio:Affection a owl:Class ;
  rdfs:comment """affection is an emotion characterized with a feeling or type of love for another living thing.
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:Affiliation a owl:Class ;
  rdfs:comment """An affiliation is a social relation which indicates the partnership between two or more entities.
""" ;
  rdfs:subClassOf sio:SocialRelation .

sio:Age a owl:Class ;
  rdfs:comment "age is the length of time that a person has lived or a thing has existed." ;
  rdfs:subClassOf sio:DimensionalQuantity .

sio:AggregatedCarbonNanorods a owl:Class ;
  rdfs:comment """aggregate of carbon nanorods is an allotrope of carbon considered to be the least compressible material known, as measured by its isothermal bulk modulus; aggregated diamond nanorods have a modulus of 491 gigapascals (GPa), while a conventional diamond has a modulus of 442 GPa. ADNRs are also 0.3% denser than regular diamond.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:Agreement a owl:Class ;
  rdfs:comment """agreement is the result of consensus decision making when members of the group agree.
""" ;
  rdfs:subClassOf sio:AgreementQuality .

sio:AgreementQuality a owl:Class ;
  rdfs:comment """agreement quality is a quality that exhibits the degree of consensus for some set of assertions.
""" ;
  rdfs:subClassOf sio:InformationalQuality .

sio:Algorithm a owl:Class ;
  rdfs:comment """An algorithm is an effective method expressed as a finite list of well-defined instructions for calculating a function.
""" ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:Alive a owl:Class ;
  rdfs:comment "alive is the state of a biological organism that exhibits biological functions." ;
  rdfs:subClassOf sio:LifeStatus .

sio:Allele a owl:Class ;
  rdfs:comment "An allele is one of a set of sequence variants of a gene." ;
  rdfs:subClassOf sio:Gene .

sio:AllostericSite a owl:Class ;
  rdfs:comment """An allosteric site is a binding site that when bound to particular ligand changes the conformational state and affects its functionality.
""" ;
  rdfs:subClassOf sio:BindingSite .

sio:Allotrope a owl:Class ;
  rdfs:comment "An allotrope is a structural variant of a chemical element." ;
  rdfs:subClassOf sio:ChemicalElement .

sio:AlphaHelix a owl:Class ;
  rdfs:comment """An alpha helix is structural region of a protein that is characterized by 3.6 residues per turn,  a translation of 1.5 angstroms along the helical axis in which backbone N-H groups form a hydrogen bond to the backbone carboxyl group of the amino acid four residues prior.
""" ;
  rdfs:subClassOf sio:AminoAcidPolymerSubmolecule .

sio:Altitude a owl:Class ;
  rdfs:comment "Altitude is a distance above sea level." ;
  rdfs:subClassOf sio:Position .

sio:AluminiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Always a owl:Class ;
  rdfs:comment "always indicates that the event occurs at all times." ;
  rdfs:subClassOf sio:TemporalQualifier .

sio:AmericiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:AminoAcid a owl:Class ;
  rdfs:comment """An amino acid is an organic molecule composed of a carbon bonded to four different groups: a carboxyl group, an amino group, an R group, and a hydrogen atom. In the case of glycine, the R group is another hydrogen atom.
""" ;
  rdfs:subClassOf sio:OrganicMolecule .

sio:AminoAcidPolymer a owl:Class ;
  rdfs:comment """an amino acid polymer is an organic polymer composed of two or more amino acid residues.
""" ;
  rdfs:subClassOf sio:OrganicPolymer .

sio:AminoAcidPolymerSubmolecule a owl:Class ;
  rdfs:comment "An amino acid polymer submolecule is a submolecule of an amino acid polymer." ;
  rdfs:subClassOf sio:OrganicSubmolecule .

sio:AminoAcidResidue a owl:Class ;
  rdfs:comment """An amino acid residue is a submolecule of an amino acid that is part of a larger molecule.
""" ;
  rdfs:subClassOf sio:AminoAcidPolymerSubmolecule .

sio:AmorphousCarbon a owl:Class ;
  rdfs:comment """amorphous carbon is an allotrope of carbon that does not have any crystalline structure. As with all glassy materials, some short-range order can be observed, but there is no long-range pattern of atomic positions.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:Anabolism a owl:Class ;
  rdfs:comment """Anabolism is the set of metabolic processes that construct larger chemical entities units from smaller chemical entities.
""" ;
  rdfs:subClassOf sio:Metabolism .

sio:Analyte a owl:Class ;
  rdfs:comment """an analyte is a substance or chemical constituent of interest in an analytical procedure.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:AnatomicalEntity a owl:Class ;
  rdfs:comment """an anatomical entity is an object that is a structural part (material or immaterial) of a biological entity.
""" ;
  rdfs:subClassOf sio:SpecializedObject .

sio:Anger a owl:Class ;
  rdfs:comment "anger is disgust directed toward an equal status individual." ;
  rdfs:subClassOf sio:Disgust .

sio:Angst a owl:Class ;
  rdfs:comment "angst is the intense feeling of apprehension, anxiety or inner turmoil." ;
  rdfs:subClassOf sio:Anxiety .

sio:Anion a owl:Class ;
  rdfs:comment "An anion is an atom or molecule with a net negative electrical charge." ;
  rdfs:subClassOf sio:Ion .

sio:Annotation a owl:Class ;
  rdfs:comment """An annotation is a written explanatory or critical description, or other in-context information (e.g., pattern, motif, link), that has been associated with data or other types of information.
""" ;
  rdfs:subClassOf sio:Description .

sio:Annoyance a owl:Class ;
  rdfs:comment """Annoyance is an unpleasant emtion that is characterized by a abnormal or excessive sensitivity to some external stimulus.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Answer a owl:Class ;
  rdfs:comment "An answer is a reply to a question." ;
  rdfs:subClassOf sio:Description .

sio:Antibody a owl:Class ;
  rdfs:comment """An antibody (also known as immunoglobulins, abbreviated Ig) are gamma globulin proteins that are used by the immune system to identify and neutralize foreign objects. They are typically made of two large heavy chains and two small light chains.
""" ;
  rdfs:subClassOf sio:ProteinComplex .

sio:Antigen a owl:Class ;
  rdfs:comment """An antigen is a molecule that can be bound by a major histocompatibility complex (MHC) and presented to a T-cell receptor.
""" ;
  rdfs:subClassOf sio:Molecule .

sio:AntimonyAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:AntiportEnabledSecondaryActiveTransport a owl:Class ;
  rdfs:comment """antiport enabled secondary active transport is a secondary active transfort in which both ion and molecule are transported in opposite directions simultaneously.
""" ;
  rdfs:subClassOf sio:SecondaryActiveTransport .

sio:Antonym a owl:Class ;
  rdfs:comment "An antonym is a word with opposite or nearly opposite meaning." ;
  rdfs:subClassOf sio:TermVariant .

sio:Anxiety a owl:Class ;
  rdfs:comment """anxiety is an emotion charactersized by intense feeling of fear and concern coupled with a physical response.
""" ;
  rdfs:subClassOf sio:Apprehension .

sio:ApartmentNumber a owl:Class ;
  rdfs:comment """An apartment number is the number assigned to identify an apartment in a building of apartments.
""" ;
  rdfs:subClassOf sio:PositionalIdentifier .

sio:Apathy a owl:Class ;
  rdfs:comment "apathy is an emotion characterized by lack of interest, enthusiasm, or concern." ;
  rdfs:subClassOf sio:Indifference .

sio:Apprehension a owl:Class ;
  rdfs:comment "apprehension is the negative emotion that something unpleasant will occur." ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Arc a owl:Class ;
  rdfs:comment "an arc is a closed segment of a differentiable curve." ;
  rdfs:subClassOf sio:Curve .

sio:Area a owl:Class ;
  rdfs:comment """area is a quantity that pertains to the extent of a two-dimensional surface or shape, or planar lamina, in the plane.
""" ;
  rdfs:subClassOf sio:2DExtentQuantity .

sio:ArgonAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Argument a owl:Class ;
  rdfs:comment """An argument is a set of one or more declarative sentences (or propositions) known as the premises along with another declarative sentence (or proposition) known as the conclusion.
""" ;
  rdfs:subClassOf sio:Proposition .

sio:AromaticBond a owl:Class ;
  rdfs:comment """An aromatic bond is an interaction between a set of atoms across which pairs of electrons are shared.
""" ;
  rdfs:subClassOf sio:CovalentBond .

sio:AromaticRing a owl:Class ;
  rdfs:comment """An aromatic ring is a ring in which the electrons are delocalized across all atoms in the ring.
""" ;
  rdfs:subClassOf sio:Ring .

sio:Arousal a owl:Class ;
  rdfs:comment """arousal is an emotion characterized by state of reactive to stimuli. It involves the activation of the reticular activating system in the brain stem, the autonomic nervous system and the endocrine system, leading to increased heart rate and blood pressure and a condition of sensory alertness, mobility and readiness to respond.
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:ArrowedLineSegment a owl:Class ;
  rdfs:comment """An arrowed line is a directed line segment in which one or both endpoints is tangentially part of a triangle that bisects the line.
""" ;
  rdfs:subClassOf sio:DirectedLineSegment .

sio:ArsenicAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Article a owl:Class ;
  rdfs:comment "An article is a publication that is stand-alone section of a larger work." ;
  rdfs:subClassOf sio:Publication .

sio:AspectRatio a owl:Class ;
  rdfs:comment """The aspect ratio of a geometric shape is the ratio of its sizes in different dimensions.
""" ;
  rdfs:subClassOf sio:Ratio .

sio:Assay a owl:Class ;
  rdfs:comment """An assay is an investigative (analytic) procedure in laboratory medicine, pharmacology, environmental biology, and molecular biology for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity (the analyte) which can be a drug or biochemical substance or a cell in an organism or organic sample.
""" ;
  rdfs:subClassOf sio:Procedure .

sio:AssertionOvopub a owl:Class ;
  rdfs:comment """An assertion ovopub is an ovopub that contains and links to an assertion subgraph with one or more statements that may be true or false, as well as statements describing its provenance.
""" ;
  rdfs:subClassOf sio:Ovopub .

sio:AssertionalQualifier a owl:Class ;
  rdfs:comment """An assertional qualifier is the quality of affirmation, either being positive or negative.
""" ;
  rdfs:subClassOf sio:Quality .

sio:Association a owl:Class ;
  rdfs:comment """An assocation is a relationship between two or more entities derived by some informational analysis.
""" ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:AstatineAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Atom a owl:Class ;
  rdfs:comment """An atom is composed of a core of protons and/or neutrons which may be surrounded by a cloud of electrons.
""" ;
  rdfs:subClassOf sio:ChemicalEntity , [
    a owl:Restriction ;
    owl:onProperty sio:is_covalently_connected_totransitive ;
    owl:allValuesFrom sio:Atom
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_covalently_connected_totransitive ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Attribute a owl:Class ;
  rdfs:comment "An attribute is a characteristic of some entity." ;
  rdfs:subClassOf sio:Entity .

sio:AudioRecording a owl:Class ;
  rdfs:comment """An audio recording is an electrical or mechanical inscription and re-creation of sound waves, such as spoken voice, singing, instrumental music, or sound effects.
""" ;
  rdfs:subClassOf sio:Media .

sio:AuthorContributionSection a owl:Class ;
  rdfs:comment """An author contribution section is a document section that describes the contribution of the authors.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:AuthorList a owl:Class ;
  rdfs:comment "an ordered list of authors." ;
  rdfs:subClassOf sio:OrderedList .

sio:AuthorRole a owl:Class ;
  rdfs:comment """An author role is the role of an individual that creates a creative, written work.
""" ;
  rdfs:subClassOf sio:PublishingRole .

sio:AuthorSection a owl:Class ;
  rdfs:comment "An author section is a document section that lists the contributing authors." ;
  rdfs:subClassOf sio:DocumentSection .

sio:Awe a owl:Class ;
  rdfs:comment """awe is an emotion produced by that which is grand, sublime or powerful and is characterized by a combination of joy, fear and admiration/reverence/respect. 
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:Axis a owl:Class ;
  rdfs:comment """An axis is a line segment that is part of a statistical graph in which the 
position along the line corresponds to a numeric or categorical value.
""" ;
  rdfs:subClassOf sio:DirectedLineSegment .

sio:Bar a owl:Class ;
  rdfs:comment """A bar is a rectangle that is located in the plot of a statistical graph in which its length is proportional to the values that it represents.
""" ;
  rdfs:subClassOf sio:Rectangle .

sio:BarGraph a owl:Class ;
  rdfs:comment """A bar graph is a statistical graph with rectangular bars of lengths proportional to that value that they represent.
""" ;
  rdfs:subClassOf sio:StatisticalGraph .

sio:BariumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Base a owl:Class ;
  rdfs:comment """A base is a molecular entity dissolved in a solvent that is capable of accepting a proton (Bronsted base) or forming a covalent bond with a hydron (Lewis base) .
""" ;
  rdfs:subClassOf sio:LiquidSolutionComponent .

sio:BasePair a owl:Class ;
  rdfs:comment """A base pair is a weak molecular interaction composed of hydrogen bonds between nucleobases.
""" ;
  rdfs:subClassOf sio:WeakSubmolecularComponent .

sio:BaseStack a owl:Class ;
  rdfs:comment """A base stack is a stabilizing interaction of DNA and RNA between spatially adjacent nucleotides and possibly involving London dispersion, hydrophobic and electrostatic forces.
""" ;
  rdfs:subClassOf sio:WeakSubmolecularComponent .

sio:Behaviour a owl:Class ;
  rdfs:comment """Behaviour is the set of actions and mannerisms made by systems (biological or otherwise) in response to stimuli or inputs, whether internal or external, conscious or subconscious, overt or covert, and voluntary or involuntary.
""" ;
  rdfs:subClassOf sio:Process .

sio:Belief a owl:Class ;
  rdfs:comment "A belief is a proposition that is believed to be true." ;
  rdfs:subClassOf sio:Proposition .

sio:Bent a owl:Class ;
  rdfs:comment "bent is the quality of a line being sharply curved or having an angle." ;
  rdfs:subClassOf sio:Curvature .

sio:BerkeliumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:BerylliumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:BetaStrand a owl:Class ;
  rdfs:comment """A beta strand is structural region of a protein that is characterized by a roughly planar sequence of amino acid residues forming hydrogen bonds between the N-O and the C=O  of another part of the peptide
and having their side chains perpendicular to the planar axis.
""" ;
  rdfs:subClassOf sio:AminoAcidPolymerSubmolecule .

sio:BibliographySection a owl:Class ;
  rdfs:comment """A bibliography section is a document section that is composed of a list of references used in the development of the work.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:Bill a owl:Class ;
  rdfs:comment "A bill is proposed legislation under consideration by a legislature." ;
  rdfs:subClassOf sio:LegalDocument .

sio:BinaryCompound a owl:Class ;
  rdfs:comment """A binary compound is a mereological maximum sum of two kinds of weakly connected entities.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:BinaryScale a owl:Class ;
  rdfs:comment """A binary scale is a measurement scale that specifies a choice between two values.
""" ;
  rdfs:subClassOf sio:MeasurementScale .

sio:BindingSite a owl:Class ;
  rdfs:comment """A binding site is a molecular site which when occupied with particular ligands leads to structural transformations that initiatiate new moelcular processes. 
""" ;
  rdfs:subClassOf sio:MolecularSite .

sio:BiochemicalActivation a owl:Class ;
  rdfs:comment """biochemical activation is a molecular interaction that increases the catalytic rate of the target enzyme.
""" ;
  rdfs:subClassOf sio:RegulationOfCatalyticCapability .

sio:BiochemicalInhibition a owl:Class ;
  rdfs:comment """biochemical inhibition is a molecular interaction that decreases the catalytic rate of the target enzyme.
""" ;
  rdfs:subClassOf sio:RegulationOfCatalyticCapability .

sio:BiochemicalPathway a owl:Class ;
  rdfs:comment """A biochemical pathway specifies a series of biochemical modifications and transformations towards achieving some biological outcome.
""" ;
  rdfs:subClassOf sio:ChemicalReactionPathway .

sio:BiochemicalReaction a owl:Class ;
  rdfs:comment """A biochemical reaction is a biochemical process that involves the conversion of at least one chemical participant (target) into another (product) by an enzyme (agent).
""" ;
  rdfs:subClassOf sio:CatalyzedReaction .

sio:BioinformaticData a owl:Class ;
  rdfs:comment """bioinformatic data is data genereated or used for computer-based investigations of biological phenomena.
""" ;
  rdfs:subClassOf sio:BiologicalData .

sio:Biologic a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:PharmaceuticalDrug .

sio:BiologicalData a owl:Class ;
  rdfs:comment "biological data is scientific data relevant to biology." ;
  rdfs:subClassOf sio:ScientificData .

sio:BiologicalEntity a owl:Class ;
  rdfs:comment """A biological entity is a heterogeneous substance that contains genomic material or is the product of a biological process.
""" ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:BiologicalFluid a owl:Class ;
  rdfs:comment "A biological fluid is a fluid of biological origin." ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:BiologicalQuality a owl:Class ;
  rdfs:comment "A biological quality is a quality held by a biological entity." ;
  rdfs:subClassOf sio:ObjectQuality .

sio:BiologicalReproduction a owl:Class ;
  rdfs:comment """biological reproduction is the biological process by which one or more biological organisms are produced from their \"parents\". 
""" ;
  rdfs:subClassOf sio:Reproducing .

sio:BiologicalSex a owl:Class ;
  rdfs:comment """biological sex is the quality of a biological organism based on reproductive function or organs.
""" ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:BiomolecularStructureDescriptor a owl:Class ;
  rdfs:comment """A biomolecular structure descriptor is structure description for organic compounds.
""" ;
  rdfs:subClassOf sio:MolecularStructureDescriptor .

sio:Biopolymer a owl:Class ;
  rdfs:comment """A biopolymer is an organic polymer that are typically produced by the cells of living organisms.
""" ;
  rdfs:subClassOf sio:OrganicPolymer .

sio:BiopolymerSequence a owl:Class ;
  rdfs:comment """A sequence is a primary structure descriptor in which each of the letters in the string represents a monomeric unit (residue) in which adjacent letters represent the connectivity between the monomeric units.
""" ;
  rdfs:subClassOf sio:PrimaryStructureDescriptor .

sio:Biosynthesis a owl:Class ;
  rdfs:comment """biosynthesis is the synthesis of an organic compound in a living organism, usually aided by enzymes.
""" ;
  rdfs:subClassOf sio:ChemicalSynthesis .

sio:Birthing a owl:Class ;
  rdfs:comment """birthing is the process by which a biological organism is brought into existence.
""" ;
  rdfs:subClassOf sio:Creating .

sio:BismuthAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:BlockHistogram a owl:Class ;
  rdfs:comment """A block histogram contains an x-axis that is divided into bins which correspond to value ranges. Each item in the data set is drawn as a rectangular block, and the blocks are piled into the bins to show how many values in each range.
""" ;
  rdfs:subClassOf sio:Histogram .

sio:Blog a owl:Class ;
  rdfs:comment """A blog is a publication accessible at some website and is typically about various experiences.
""" ;
  rdfs:subClassOf sio:Publication .

sio:BohriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Boldness a owl:Class ;
  rdfs:comment """boldness is the trait of being willing to undertake things that involve risk or danger.
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:Book a owl:Class ;
  rdfs:comment "A book is a publication composed of a large number of entries." ;
  rdfs:subClassOf sio:Publication .

sio:BookSection a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:DocumentSection .

sio:BookSeries a owl:Class ;
  rdfs:comment "A book series is a collection of books that have been sequentially published." ;
  rdfs:subClassOf sio:CollectionOfDocuments .

sio:BookVolume a owl:Class ;
  rdfs:comment "A book volume is a book that is part of a collection." ;
  rdfs:subClassOf sio:Book .

sio:Booklet a owl:Class ;
  rdfs:comment "A booklet is a document that lacks a named publisher or sponsoring institution." ;
  rdfs:subClassOf sio:Document .

sio:Boredom a owl:Class ;
  rdfs:comment """boredom is the emotion experience by those not interested in their surroundings or available activities.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:BoronAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:BottomValueAxis a owl:Class ;
  rdfs:comment """A bottom value axis is a value axis that is spatially positioned to the bottom of the plot area.
""" ;
  rdfs:subClassOf sio:ValueAxis .

sio:Boxplot a owl:Class ;
  rdfs:comment """A boxplot (box-and-whisker diagram) is a convenient way of graphically depicting groups of numerical data through their five-number summaries: the smallest observation (sample minimum), lower quartile (Q1), median (Q2), upper quartile (Q3), and largest observation (sample maximum).
""" ;
  rdfs:subClassOf sio:LineBarGraph .

sio:BrandName a owl:Class ;
  rdfs:comment "A brand name is a trademarked and marketed name of a product." ;
  rdfs:subClassOf sio:Name .

sio:Brief a owl:Class ;
  rdfs:comment """A brief is a written legal document used in various legal adversarial systems that is presented to a court arguing why one party to a particular case should prevail.
""" ;
  rdfs:subClassOf sio:LegalDocument .

sio:BromineAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:BrownianMotion a owl:Class ;
  rdfs:comment """Brownian motion is the seemlingly random movement of particles suspended in a fluid.
""" ;
  rdfs:subClassOf sio:Diffusion .

sio:BubbleChart a owl:Class ;
  rdfs:comment "A bubble chart contains circles whose area corresponds to a value. " ;
  rdfs:subClassOf sio:Chart .

sio:Buffer a owl:Class ;
  rdfs:comment """A buffer is a dissolved chemical substance that resists change in pH upon addition of small amounts of acid or base.
""" ;
  rdfs:subClassOf sio:LiquidSolutionComponent .

sio:BufferRole a owl:Class ;
  rdfs:comment """A buffer role is the role of a chemical substance which maintains a pH at a near constant value.
""" ;
  rdfs:subClassOf sio:ChemicalSubstanceRole .

sio:CadmiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:CaesiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:CalciumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:CaliforniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Cancelled a owl:Class ;
  rdfs:comment """cancelled is a process status in which the process, while planned to occur, will not occur.
""" ;
  rdfs:subClassOf sio:NotStarted .

sio:Capability a owl:Class ;
  rdfs:comment """A capability is a realizable entity whose basis lies in one or more parts or qualities and reflects possibility of an entity to behave in a specified way under certain conditions or in response to a certain stimulus (trigger).
""" ;
  rdfs:subClassOf sio:RealizableEntity , [
    a owl:Restriction ;
    owl:onProperty sio:is_capability_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_capability_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Carbohydrate a owl:Class ;
  rdfs:comment "a carbohydrate is an organic molecule composed of two or more monosaccharides." ;
  rdfs:subClassOf sio:OrganicPolymer .

sio:CarbohydrateResidue a owl:Class ;
  rdfs:comment """A carbohydrate residue is a part of a molecule that was derived from a monosaccharide molecule.
""" ;
  rdfs:subClassOf sio:OrganicSubmolecule .

sio:CarbonAllotrope a owl:Class ;
  rdfs:comment "A carbon allotrope is a chemical substance composed of carbon." ;
  rdfs:subClassOf sio:Allotrope .

sio:CarbonAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:CarbonNanofoam a owl:Class ;
  rdfs:comment """carbon nanofoam is an allotrope of carbon that consists of a low-density cluster-assembly of carbon atoms strung together in a loose three-dimensional web. Each cluster is about 6 nanometers wide and consists of about 4000 carbon atoms linked in graphite-like sheets that are given negative curvature by the inclusion of heptagons among the regular hexagonal pattern.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:CartesianCoordinate a owl:Class ;
  rdfs:comment "A Cartesian coordinate is the signed distance of a point to some referent line." ;
  rdfs:subClassOf sio:Coordinate .

sio:CartesianCoordinateAxis a owl:Class ;
  rdfs:comment """A Cartesian coordinate axis is an axis whose behavior follows that of a Cartesian coordinate system.
""" ;
  rdfs:subClassOf sio:ValueAxis .

sio:CartesianCoordinateSystem a owl:Class ;
  rdfs:comment """A Cartesian coordinate system specifies each point uniquely in a plane by a pair of numerical coordinates, which are the signed distances from the point to two fixed perpendicular directed lines, measured in the same unit of length.
""" ;
  rdfs:subClassOf sio:CoordinateSystem .

sio:Catabolism a owl:Class ;
  rdfs:comment """Anabolism is the set of metabolic processes that take apart larger chemical entities units into smaller chemical entities.
""" ;
  rdfs:subClassOf sio:Metabolism .

sio:Catalog a owl:Class ;
  rdfs:comment "A catalog is a systemic collection of items of the same type." ;
  rdfs:subClassOf sio:Collection .

sio:Catalyst a owl:Class ;
  rdfs:comment """A catalyst is a molecule that has the capability to reduce the activation energy of a reaction and hence increase the overall rate of reaction.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:CatalyticRole a owl:Class ;
  rdfs:comment """The role of a chemical participant that serves to increase the rate of reaction by lowering the activiation energy.
""" ;
  rdfs:subClassOf sio:RegulatorRole .

sio:CatalyzedReaction a owl:Class ;
  rdfs:comment "A catalyzed reaction is a chemical reaction that is facilitated by a catalyst." ;
  rdfs:subClassOf sio:ChemicalReaction .

sio:Category a owl:Class ;
  rdfs:comment "A category is a class of entities having particular shared characteristics." ;
  rdfs:subClassOf sio:Concept .

sio:CategoryAxis a owl:Class ;
  rdfs:comment """A category axis is an axis in which the position along the line is partioned into categories.
""" ;
  rdfs:subClassOf sio:Axis .

sio:Cation a owl:Class ;
  rdfs:comment "An anion is an atom or molecule with a net positive electrical charge." ;
  rdfs:subClassOf sio:Ion .

sio:CationPiInteraction a owl:Class ;
  rdfs:comment """A cation pi interaction is an ionic interaction between the localized negative charge of π orbital electrons, located above and below the plane of an aromatic ring, and a positive charge.
""" ;
  rdfs:subClassOf sio:IonicInteraction .

sio:Cell a owl:Class ;
  rdfs:comment "A cell is a biological entity that is contained by a plasma membrane." ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:CellLine a owl:Class ;
  rdfs:comment "A cell line is a collection of genetically identifical cells." ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:Cellinformational a owl:Class ;
  rdfs:comment """The minimal unit of a cellular automaton that can change state and has an associated behavior.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:CellularOrganism a owl:Class ;
  rdfs:comment "A cellular organism is an organism that contains one or more cells." ;
  rdfs:subClassOf sio:Organism .

sio:CellularPhoneNumber a owl:Class ;
  rdfs:comment "a cellular phone number is a number to connect to a mobile device" ;
  rdfs:subClassOf sio:TelephoneNumber .

sio:CellularQuality a owl:Class ;
  rdfs:comment "cellular quality is the quality of a cell" ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:CenterOfMass a owl:Class ;
  rdfs:comment """The center of mass (aka barycenter) is the weighted average location of all the mass in a body or group of bodies.
""" ;
  rdfs:subClassOf sio:Position .

sio:CentralityMeasure a owl:Class ;
  rdfs:comment """A central tendency measure is a central value or a typical value for a probability distribution.
""" ;
  rdfs:subClassOf sio:Quantity .

sio:CentrifugationPellet a owl:Class ;
  rdfs:comment """A centrifugation pellet is a solid substance that forms as a result of compaction by a centrifuge.
""" ;
  rdfs:subClassOf sio:CentrifugationSubstance .

sio:CentrifugationSubstance a owl:Class ;
  rdfs:comment """A centrifugation substance is a substance that is the target or product of centrifugation.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:Century a owl:Class ;
  rdfs:comment "A century is a period of one hundred years." ;
  rdfs:subClassOf sio:TimeInterval .

sio:CeriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Chaoite a owl:Class ;
  rdfs:comment """chaoite is an allotrope of carbon that is slightly harder than graphite with a reflection colour of grey to white.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:Chapter a owl:Class ;
  rdfs:comment "A chapter is a document section of a book or thesis." ;
  rdfs:subClassOf sio:DocumentSection .

sio:Character a owl:Class ;
  rdfs:comment "A character is a language symbol used to construct words." ;
  rdfs:subClassOf sio:LanguageEntity .

sio:CharacterPosition a owl:Class ;
  rdfs:comment "The ordinal position of a character in a sequence of characters." ;
  rdfs:subClassOf sio:OrdinalPosition .

sio:ChargeQuality a owl:Class ;
  rdfs:comment "charge quality is the quality pertaining to electric charge." ;
  rdfs:subClassOf sio:ChemicalQuality .

sio:Charged a owl:Class ;
  rdfs:comment "The quality of having a charge." ;
  rdfs:subClassOf sio:ChargeQuality .

sio:Chart a owl:Class ;
  rdfs:comment """A chart is a figure that displays the relationship among tabular numeric data, functions or some kinds of qualitative structures.
""" ;
  rdfs:subClassOf sio:Figure .

sio:ChemicalDiseaseAssociation a owl:Class ;
  rdfs:comment """A chemical-disease association is an association between a chemical and a disease.
""" ;
  rdfs:subClassOf sio:Association .

sio:ChemicalGeneAssocation a owl:Class ;
  rdfs:comment "a chemical-gene assocation is an assocation between a chemical and a gene." ;
  rdfs:subClassOf sio:Association .

sio:ChemicalPathwayAssociation a owl:Class ;
  rdfs:comment """a chemical-pathway association is an association between a chemical and a pathway.
""" ;
  rdfs:subClassOf sio:Association .

sio:ChemicalComplex a owl:Class ;
  rdfs:comment """A chemical complex is a chemical substance composed of weakly connected molecules and ions in a known stoichiometry.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:ChemicalData a owl:Class ;
  rdfs:comment """A chemical datum is a scientific data item which conforms to some specification, either for how it is calculated or for how it is measured, and is commonly used in the domain of chemistry to name and differentiate different numeric properties (both calculated and measured) which are about chemical entities.
""" ;
  rdfs:subClassOf sio:ScientificData .

sio:ChemicalDegradationPathway a owl:Class ;
  rdfs:comment """A chemical degradation pathway is a pathway involved in the disassembly of a chemical.
""" ;
  rdfs:subClassOf sio:ChemicalReactionPathway .

sio:ChemicalDestruction a owl:Class ;
  rdfs:comment """chemical destruction is destruction of a chemical entity to its chemical constituents through one ormore chemical interactions or reactions.
""" ;
  rdfs:subClassOf sio:Destroying .

sio:ChemicalEffect a owl:Class ;
  rdfs:comment """A chemical effect is a chemical interaction in which a chemical elicits a marked characteristic of a biological system.
""" ;
  rdfs:subClassOf sio:ChemicalInteraction .

sio:ChemicalElement a owl:Class ;
  rdfs:comment """A chemical element is a (effectively) homogeneous substance composed of one type of atom.
""" ;
  rdfs:subClassOf sio:HomogeneousSubstance .

sio:ChemicalEntity a owl:Class ;
  rdfs:comment "A chemical entity is a material entity that pertains to chemistry." ;
  rdfs:subClassOf sio:MaterialEntity .

sio:ChemicalEntityRole a owl:Class ;
  rdfs:comment "A chemical role is a processual role held by a chemical entity." ;
  rdfs:subClassOf sio:ProcessualRole .

sio:ChemicalExposure a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:ChemicalInteraction .

sio:ChemicalFunctionalGroup a owl:Class ;
  rdfs:comment """A chemical functional group is a submolecule that confers specific chemical properties.
""" ;
  rdfs:subClassOf sio:Submolecule .

sio:ChemicalIdentifier a owl:Class ;
  rdfs:comment "A chemical identifier is an identifier for a chemical entity" ;
  rdfs:subClassOf sio:PhysicalEntityIdentifier .

sio:ChemicalInteraction a owl:Class ;
  rdfs:comment """A chemical interaction is a biochemical process in which chemical entities interact through some set of attractive forces.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:ChemicalNotation a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Notation .

sio:ChemicalQuality a owl:Class ;
  rdfs:comment "chemical quality is the quality of a chemical entity." ;
  rdfs:subClassOf sio:ObjectQuality .

sio:ChemicalReaction a owl:Class ;
  rdfs:comment """A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.
""" ;
  rdfs:subClassOf sio:ChemicalInteraction .

sio:ChemicalReactionPathway a owl:Class ;
  rdfs:comment """A chemical reaction pathway specifies a series of chemical reactions towards producing some chemical product.
""" ;
  rdfs:subClassOf sio:Pathway .

sio:ChemicalSalt a owl:Class ;
  rdfs:comment """a chemical salt is a heterogenous substance composed of an ionic assembly of cations and anions.
""" ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:ChemicalStructure a owl:Class ;
  rdfs:comment """chemical structure is the structure of a chemical entity in terms of its molecular geometry and electronic structure.
""" ;
  rdfs:subClassOf sio:Structure .

sio:ChemicalSubstance a owl:Class ;
  rdfs:comment """A chemical substance is a chemical entity composed of two or more weakly (non-covalently) interacting chemical entities.
""" ;
  rdfs:subClassOf sio:ChemicalEntity .

sio:ChemicalSubstanceRole a owl:Class ;
  rdfs:comment """A chemical substance role is a chemical entity role held by a chemical substance.
""" ;
  rdfs:subClassOf sio:ChemicalEntityRole .

sio:ChemicalSynthesis a owl:Class ;
  rdfs:comment """chemical synthesis is synthesis of a chemical entity from physical precursors through one or more chemical interactions or reactions.
""" ;
  rdfs:subClassOf sio:Creating .

sio:ChemicalSynthesisPathway a owl:Class ;
  rdfs:comment """A chemical synthesis pathway is a pathway involved in the assembly of a chemical.
""" ;
  rdfs:subClassOf sio:ChemicalReactionPathway .

sio:ChemicalTransport a owl:Class ;
  rdfs:comment """chemical transport is the directed movement of a chemical entity by some agent (e.g. transporter).
""" ;
  rdfs:subClassOf sio:Transporting .

sio:ChlorineAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:ChromiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Chromosome a owl:Class ;
  rdfs:comment """A chromosome is a molecular complex of circular or linear DNA and bound proteins.
""" ;
  rdfs:subClassOf sio:MolecularComplex .

sio:CircularlyHelical a owl:Class ;
  rdfs:comment """a circularly helical quality is the quality of a helix that is connected in a circle or loop.
""" ;
  rdfs:subClassOf sio:Helicity .

sio:Circumference a owl:Class ;
  rdfs:comment """circumference is the length of the outline of a circle or ellipse. it is defined as c = 2*pi*r, where r is the radius.
""" ;
  rdfs:subClassOf sio:LengthOfPerimeter .

sio:CisRegulatoryElement a owl:Class ;
  rdfs:comment """A cisregulatory element is a DNA sequence located on the same DNA strand or chromosome as the gene whose expression it affects. 
""" ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Citation a owl:Class ;
  rdfs:comment """A citation is a textual entity which denotes a source described in the bibliography or reference section of a document.
""" ;
  rdfs:subClassOf sio:DocumentComponent .

sio:City a owl:Class ;
  rdfs:comment "A city is a relatively large and permanent settlement." ;
  rdfs:subClassOf sio:GeopoliticalRegion .

sio:Class a owl:Class ;
  rdfs:comment """A class is a collection of sets which can be unambiguously defined by a property that all its members share.
""" ;
  rdfs:subClassOf sio:Set .

sio:Clause a owl:Class ;
  rdfs:comment "A clause consists of a subject and a predicate." ;
  rdfs:subClassOf sio:Sentence .

sio:ClinicalTrial a owl:Class ;
  rdfs:comment """A clinical trial is an intervention trial to determine the safety and efficacy of  medical interventions (e.g., drugs, diagnostics, devices, therapy protocols). 
""" ;
  rdfs:subClassOf sio:InterventionStudy .

sio:ClosedInterval a owl:Class ;
  rdfs:comment """A closed interval is an interval that includes its endpoints, and is denoted with square brackets.
""" ;
  rdfs:seeAlso sio:RightClosedInterval ;
  rdfs:subClassOf sio:LeftClosedInterval .

sio:CoEnzymeRole a owl:Class ;
  rdfs:comment """A co-factor role in which the chemical entity is modified during catalysis and must be regenerated.
""" ;
  rdfs:seeAlso sio:CofactorRole ;
  rdfs:subClassOf sio:SubstrateRole .

sio:CoSubstrateRole a owl:Class ;
  rdfs:comment """A co-enzyme role of a chemical entity that is transiently associated, and is regenerated in a separate reaction.
""" ;
  rdfs:subClassOf sio:CoEnzymeRole .

sio:CobaltAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:CodingFrameOffset a owl:Class ;
  rdfs:comment """a coding frame offset is a numeric value that indicates the number of bases from a reference start codon position.
""" ;
  rdfs:subClassOf sio:ChemicalQuality .

sio:CodingSequence a owl:Class ;
  rdfs:comment """a coding sequence is a sequence of nucleotides which encode a RNA or protein product..
""" ;
  rdfs:subClassOf sio:NucleicAcidSequence .

sio:CofactorRole a owl:Class ;
  rdfs:comment """The role of a chemical entity involved in the mechanism for enzyme-mediated catalysis.
""" ;
  rdfs:subClassOf sio:MolecularEntityRole .

sio:Collection a owl:Class ;
  rdfs:comment """A collection is a set for which there exists at least one member, although any member need not to exist at any point in the collection's existence.
""" ;
  rdfs:subClassOf sio:Set , [
    a owl:Restriction ;
    owl:onProperty sio:has_member ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_member ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:CollectionItem a owl:Class ;
  rdfs:comment "a collection item is an item in a collection." ;
  rdfs:subClassOf sio:SetItem .

sio:CollectionOf3DMolecularStructureModels a owl:Class ;
  rdfs:comment "A collection of 3D molecular structure models is just that." ;
  rdfs:subClassOf sio:Collection .

sio:CollectionOfDocuments a owl:Class ;
  rdfs:comment "A collection of documents is a non-zero set of documents." ;
  rdfs:subClassOf sio:Collection .

sio:CollectionOfPoints a owl:Class ;
  rdfs:comment """A collection of points is a geometric entity that contains a non-zero set of geometric points. 
""" ;
  rdfs:seeAlso sio:GeometricEntity ;
  rdfs:subClassOf sio:Collection .

sio:CollectionOvopub a owl:Class ;
  rdfs:comment """A collection ovopub is an ovopub that contains and links to one or more assertion subgraphs and/or ovopubs, as well as statements describing its provenance. It is used to share a specific set of items or restrict a search to the resources contained therein.
""" ;
  rdfs:subClassOf sio:Ovopub .

sio:Collective a owl:Class ;
  rdfs:comment """A collective is a group of entities that share or are motivated by at least one common issue or interest, or work together on a specific project(s) to achieve a common objective.
""" ;
  rdfs:subClassOf sio:SocialStructure .

sio:Column a owl:Class ;
  rdfs:comment "A column is a vertical sequence of cells in a cellular automata." ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:Comment a owl:Class ;
  rdfs:comment """A comment is a verbal or written remark often related to an added piece of information, or an observation or statement.
""" ;
  rdfs:subClassOf sio:Proposition .

sio:CommonName a owl:Class ;
  rdfs:comment "A common name is a name that is commonly used." ;
  rdfs:subClassOf sio:Name .

sio:Communicating a owl:Class ;
  rdfs:comment """communicating is the process of conveying information through the exchange of thoughts, messages, or information, as by speech, visuals, signals, writing, or behaviour.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:CommunicationDevice a owl:Class ;
  rdfs:comment """A communication device is a device that facilitates the transmission of information through encoded in an audio or digital signal between a sender and a receiver.
""" ;
  rdfs:subClassOf sio:Device .

sio:Community a owl:Class ;
  rdfs:comment "A community is a sizeable social unit that shares common values." ;
  rdfs:subClassOf sio:Collective .

sio:ComparativeRole a owl:Class ;
  rdfs:comment """A comparative role is an abstract role which holds by comparing some attribute of another object of reference.
""" ;
  rdfs:subClassOf sio:AbstractRole .

sio:Comparing a owl:Class ;
  rdfs:comment """comparing is the process of examining a set of objects and determining their equality or inequality based on one or more features.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:CompleteCharge a owl:Class ;
  rdfs:comment "A complete charge is a charge where the value of the charge is a multiple of 1." ;
  rdfs:subClassOf sio:Charged .

sio:Completed a owl:Class ;
  rdfs:comment "completed is that status of a process that successfully unfolds." ;
  rdfs:subClassOf sio:ProcessStatus .

sio:CompletelyQuantifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QuantityModifier .

sio:CompositionalQuality a owl:Class ;
  rdfs:comment "composition quality is a quality that describes its composition or anatomy." ;
  rdfs:subClassOf sio:ObjectQuality .

sio:ComputationalEntity a owl:Class ;
  rdfs:comment """A computational entity is an information content entity operated on using some computational system.
""" ;
  rdfs:subClassOf sio:InformationContentEntity .

sio:Concentration a owl:Class ;
  rdfs:comment "concentration is the amount of substance per unit volume of a solution" ;
  rdfs:subClassOf sio:3DExtentQuantity .

sio:Concept a owl:Class ;
  rdfs:comment """A concept is term that refers to a generalization of a set of attributes or entities.
""" ;
  rdfs:subClassOf sio:Term .

sio:Conclusion a owl:Class ;
  rdfs:comment """A conclusion is a proposition which is reached after considering the evidence, arguments or premises.
""" ;
  rdfs:subClassOf sio:Proposition .

sio:ConferenceProceedings a owl:Class ;
  rdfs:comment "A conference proceedings is a book composed of papers presented at a conference." ;
  rdfs:subClassOf sio:Book .

sio:Conjunctionand a owl:Class ;
  rdfs:comment """AND is a logical operator that has the value true if both of its operands are true, otherwise a value of false.
""" ;
  rdfs:subClassOf sio:LogicalOperator .

sio:Consensus a owl:Class ;
  rdfs:comment """consensus is an acceptable resolution, one that can be supported, even if not the preferred outcome for each individual.
""" ;
  rdfs:subClassOf sio:Agreement .

sio:Consonant a owl:Class ;
  rdfs:comment """A consonant is a verbal entity of language that is articulated with complete or partial closure of the vocal tract.
""" ;
  rdfs:subClassOf sio:VerbalLanguageEntity .

sio:ContainmentQuality a owl:Class ;
  rdfs:comment "a containment quality is a quality of being able to contain another entity." ;
  rdfs:subClassOf sio:MereologicalQuality .

sio:Contempt a owl:Class ;
  rdfs:comment "contempt is disgust towards a lower status individual." ;
  rdfs:subClassOf sio:Disgust .

sio:Contentment a owl:Class ;
  rdfs:comment """contentment is an emotion characterized by acknowledgement and satisfaction of the current state of affairs.
""" ;
  rdfs:subClassOf sio:Happiness .

sio:ControlGroup a owl:Class ;
  rdfs:comment """A control group is a group of individuals that are not subject to an intervention of interest, but rather serve as a baseline to compare the outcomes in the intervention group.
""" ;
  rdfs:subClassOf sio:StudyGroup .

sio:ControlRole a owl:Class ;
  rdfs:comment """A control role is the role of an individual that is part of a study, but is not subject to the intervention that is to be tested.
""" ;
  rdfs:subClassOf sio:EvaluationRole .

sio:ControlVariable a owl:Class ;
  rdfs:comment """A control variable that is believed to alter the dependent or independent variables, but may not actually be the focus of the experiment. So that variable will be kept constant or monitored to try to minimise its effect on the experiment.
""" ;
  rdfs:subClassOf sio:Variable .

sio:ControlledObservationalCohortStudy a owl:Class ;
  rdfs:comment """In a controlled observational cohort study, two groups of subjects are selected from two populations that are thought to differ in only one characteristic. The groups of subjects are studied for a specific period and contrasted at the end of the study period.
""" ;
  rdfs:subClassOf sio:ObservationalStudy .

sio:Conversing a owl:Class ;
  rdfs:comment """conversing a form of interactive, spontaneous communication between two or more agents who are following rules of etiquette.
""" ;
  rdfs:subClassOf sio:Communicating .

sio:Coordinate a owl:Class ;
  rdfs:comment "A coordinate is a measurement of position in n-dimensional space." ;
  rdfs:subClassOf sio:Position .

sio:CoordinateSystem a owl:Class ;
  rdfs:comment """A coordinate system is a specification for spatial location that uses a set of numbers, or coordinates, to uniquely determine the position of a point or other geometric element.
""" ;
  rdfs:subClassOf sio:SpatialSpecification .

sio:CoperniciumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:CopperAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:CopyNumberVariation a owl:Class ;
  rdfs:comment """copy number variation refers to the number of deletions/duplications of a DNA region as compared to some reference state.
""" ;
  rdfs:subClassOf sio:Count .

sio:CopyrightSection a owl:Class ;
  rdfs:comment "A copyright section is a document section that contains a notice of copyright." ;
  rdfs:subClassOf sio:DocumentSection .

sio:Corporation a owl:Class ;
  rdfs:comment """A corporation is an organization that is granted a charter recognizing it as a separate legal entity.
""" ;
  rdfs:subClassOf sio:Organization .

sio:Correlation a owl:Class ;
  rdfs:comment """A correlation is a statistical relationship involving dependence between two random variables or datasets.
""" ;
  rdfs:subClassOf sio:StatisticalAssociation .

sio:CorrespondenceSection a owl:Class ;
  rdfs:comment """A correspondence section is a document section that contains the details for contacting the corresponding author.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:Count a owl:Class ;
  rdfs:comment "The number of elements of a finite set of objects." ;
  rdfs:subClassOf sio:DimensionlessQuantity .

sio:Country a owl:Class ;
  rdfs:comment """A country is a region legally identified as a distinct entity in political geography. 
""" ;
  rdfs:subClassOf sio:GeopoliticalRegion .

sio:CovalentBond a owl:Class ;
  rdfs:comment "A covalent bond is a strong submolecular interaction between atoms." ;
  rdfs:subClassOf sio:StrongSubmolecularComponent .

sio:Creating a owl:Class ;
  rdfs:comment "creating is the process in which an entity comes into existence." ;
  rdfs:subClassOf sio:Interacting .

sio:Criterion a owl:Class ;
  rdfs:comment "A criterion is a specification to describe properties used for evaluation." ;
  rdfs:subClassOf sio:DesignSpecification .

sio:CrystalStructure a owl:Class ;
  rdfs:comment """A crystal structure is the arrangement of atoms or molecules in a crystalline liquid or solid.
""" ;
  rdfs:subClassOf sio:MolecularStructure .

sio:Curiosity a owl:Class ;
  rdfs:comment "curiosity is the strong desire to know or learn something." ;
  rdfs:subClassOf sio:Desire .

sio:CuriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Curvature a owl:Class ;
  rdfs:comment """curvature is a quality of a bearer that relates to the presence of curves, bends, or angles.
""" ;
  rdfs:subClassOf sio:Shape .

sio:Curve a owl:Class ;
  rdfs:comment """A curve is a geometric entity that may be located in n-dimensional spatial region whose extension may be n-dimensional,  is composed of at least two fully connected points and does not intersect itself.
""" ;
  rdfs:subClassOf sio:GeometricEntity .

sio:CurveSegment a owl:Class ;
  rdfs:comment "A curve segment is a part of a curve that consists of at least three points." ;
  rdfs:subClassOf sio:Curve .

sio:Curved a owl:Class ;
  rdfs:comment """curved is the quality of a line that deviates from straightness in a smooth, continuous fashion.
""" ;
  rdfs:subClassOf sio:Curvature .

sio:CylindricalCoordinateSystem a owl:Class ;
  rdfs:comment """A cylindrical coordinate system is a three-dimensional coordinate system that specifies point positions by the distance from a chosen reference axis, the direction from the axis relative to a chosen reference direction, and the distance from a chosen reference plane perpendicular to the axis.
""" ;
  rdfs:subClassOf sio:CoordinateSystem .

sio:DarmstadtiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:DataAnalysis a owl:Class ;
  rdfs:comment """data analysis is a process of inspecting, cleaning, transforming, and modeling data with the goal of highlighting useful information, suggesting conclusions, and supporting decision making.
""" ;
  rdfs:subClassOf sio:InformationProcessing .

sio:DataCollection a owl:Class ;
  rdfs:comment "data collection is the process of acquiring information." ;
  rdfs:subClassOf sio:InformationProcessing .

sio:DataCollectionDevice a owl:Class ;
  rdfs:comment """A data collection device is a device that collects information about one or more objects.
""" ;
  rdfs:subClassOf sio:Device .

sio:DataItem a owl:Class ;
  rdfs:comment """A data item consists of information that has been collected/generated towards some purpose.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:DataPoint a owl:Class ;
  rdfs:comment """A data point is a point that which corresponds to the projection of the values of measurement data against the axes of a statistical graph.
""" ;
  rdfs:subClassOf sio:Point .

sio:DataSeries a owl:Class ;
  rdfs:comment """A data series is a data set composed of related values displayed in a statistical graph.
""" ;
  rdfs:subClassOf sio:List .

sio:DataStorageDevice a owl:Class ;
  rdfs:comment "A data storage device is a device that is capable of storing information." ;
  rdfs:subClassOf sio:Device .

sio:DataTransformation a owl:Class ;
  rdfs:comment """data transformation is the process of applying an algorithmic procedure to some input data and producing some output data.
""" ;
  rdfs:subClassOf sio:InformationProcessing .

sio:Database a owl:Class ;
  rdfs:comment "A database is a set of tables." ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:DatabaseColumn a owl:Class ;
  rdfs:comment "A database collumn is a column in a database table." ;
  rdfs:subClassOf sio:Column .

sio:DatabaseCrossReference a owl:Class ;
  rdfs:comment "A database cross-reference is an association between one data item and another." ;
  rdfs:subClassOf sio:Association .

sio:DatabaseEntry a owl:Class ;
  rdfs:comment "A database entry is a single, implicitly structured data item in a table." ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:DatabaseKey a owl:Class ;
  rdfs:comment """A database key is an informational entity whose value is constructed from one or more database columns.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:DatabaseRow a owl:Class ;
  rdfs:comment "A database row is a row that is part of a database table." ;
  rdfs:subClassOf sio:Row .

sio:DatabaseTable a owl:Class ;
  rdfs:comment """A database table is a set of named columns with zero or more rows composed of cells that contain column values and is part of a database.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:Dataset a owl:Class ;
  rdfs:comment "A dataset is a data item that is a collection of data items." ;
  rdfs:subClassOf sio:DataItem , [
    a owl:Restriction ;
    owl:onProperty sio:has_data_item ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_data_item ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:DateOfDatabaseSubmission a owl:Class ;
  rdfs:comment """A date of database submission refers to the moment in time in which some information was submitted/received to a database system.
""" ;
  rdfs:subClassOf sio:TimeInstant .

sio:DateOfIssue a owl:Class ;
  rdfs:comment "the date at which an information content entity was made public." ;
  rdfs:subClassOf sio:TimeInstant .

sio:Day a owl:Class ;
  rdfs:comment "A day is a period of 24 hours." ;
  rdfs:subClassOf sio:TimeInterval .

sio:Dead a owl:Class ;
  rdfs:comment """dead is the quality of an object in which there is a cessation of all biological functions.
""" ;
  rdfs:subClassOf sio:LifeStatus .

sio:DecimalScale a owl:Class ;
  rdfs:comment "A decimal scale of measurement is one that only specifies decimal values." ;
  rdfs:subClassOf sio:NumericScale .

sio:DecompositionReaction a owl:Class ;
  rdfs:comment """A decomposition reaction is an inorganic reaction in which molecule is fragmented into submolecules or atoms.
""" ;
  rdfs:subClassOf sio:InorganicReaction .

sio:DecreaseInNumberOfObjectsProduced a owl:Class ;
  rdfs:comment """An decrease in the number of objects produced is the negative value of a difference in number of objects produced.
""" ;
  rdfs:subClassOf sio:DifferenceInNumberOfObjectsProduced .

sio:Decreased a owl:Class ;
  rdfs:comment "A quality that has a value that is decreased compared to normal or average." ;
  rdfs:subClassOf sio:Abnormal .

sio:DecreasedChemicalDestruction a owl:Class ;
  rdfs:comment """decreased chemical destruction is a process in which there is a decrease in the amount of chemical destroyed relative to some reference process
""" ;
  rdfs:subClassOf sio:ChemicalDestruction .

sio:DecreasedDurationOfProcessFromIncreasedRegulation a owl:Class ;
  rdfs:comment """decreased duration of process from increased regulation is a process in which the duration of the target process is decreased as a result of increased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessDuration .

sio:DecreasedFrequencyOfProcessFromIncreasedRegulation a owl:Class ;
  rdfs:comment """The increase of regulation leads to a decreased occurence of processes of the target process type.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessFrequency .

sio:DecreasedMolecularDegradationFromDecreasedRegulation a owl:Class ;
  rdfs:comment """A process that decreases the frequency, rate or extent of process involved in the destruction of a molecule as a result of decreased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularDegradation .

sio:DecreasedMolecularDegradationFromIncreasedRegulation a owl:Class ;
  rdfs:comment """A process that decreases the frequency, rate or extent of process involved in the destruction of a molecule as a result of increased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularDegradation .

sio:DecreasedMolecularProductionFromDecreasedRegulation a owl:Class ;
  rdfs:comment """A process that decreases the frequency, rate or extent of process involved in the production of a molecule as a result of decreased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularProduction .

sio:DecreasedMolecularProductionFromIncreasedRegulation a owl:Class ;
  rdfs:comment """A process that decreases the frequency, rate or extent of process involved in the production of a molecule as a result of increased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularProduction .

sio:DecreasedObjectConsumptionFromIncreasedRegulation a owl:Class ;
  rdfs:comment """increased regulation leads to an decrease in the consumption of an object of specified type.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectConsumption .

sio:DecreasedObjectProductionFromIncreasedRegulation a owl:Class ;
  rdfs:comment """increased regulation leads to a decrease in the number of target objects of a specified type.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectProduction .

sio:DecreasedSpatialExtentOfProcessFromDecreasedRegulation a owl:Class ;
  rdfs:comment """The increase of regulation leads to a decreased spatial extent of the target process.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessSpatialExtent .

sio:DecreasingLine a owl:Class ;
  rdfs:comment """An decreasing line is a line segment in which the startpoint and endpoint are ordered along one dimension and the difference of values in a second dimension is negative.
""" ;
  rdfs:subClassOf sio:TrendLine .

sio:DeductiveArgument a owl:Class ;
  rdfs:comment """A deductive argument is an argument that asserts that the truth of the conclusion is a logical consequence of the premises.
""" ;
  rdfs:subClassOf sio:Argument .

sio:DefaultParameter a owl:Class ;
  rdfs:comment "A default parameter is a parameter which has a default value." ;
  rdfs:subClassOf sio:Parameter .

sio:Definition a owl:Class ;
  rdfs:comment "A definition is a description that succintly characterizes an entity." ;
  rdfs:subClassOf sio:Description .

sio:DeletionVariantRole a owl:Class ;
  rdfs:comment """A deletion variant role is the role of an sequence that lacks a sub-sequence relative to the frame of reference.
""" ;
  rdfs:subClassOf sio:SequenceVariantRole .

sio:Dendrogram a owl:Class ;
  rdfs:comment """A dendrogram is a tree diagram used to illustrate the arrangement of the clusters produced by hierarchical clustering.
""" ;
  rdfs:subClassOf sio:TreeDiagram .

sio:Density a owl:Class ;
  rdfs:comment """Density (volumetric mass density) is the quantity of mass per unit volume of a substance.
""" ;
  rdfs:subClassOf sio:3DExtentQuantity .

sio:DentistRole a owl:Class ;
  rdfs:comment """A dentist role is the role of an individual that that specializes in the diagnosis, prevention, and treatment of diseases and conditions of the oral cavity.
""" ;
  rdfs:subClassOf sio:MedicalRole .

sio:DeoxyribonucleicAcid a owl:Class ;
  rdfs:comment """A deoxyribonucleic acid is an organic polymer composed of a sequence of deoxyribonucleotide residues.
""" ;
  rdfs:subClassOf sio:NucleicAcid .

sio:DeoxyribonucleicAcidPrimer a owl:Class ;
  rdfs:comment """A deoxyribonucleic acid primer is a deoxyribonucleic acid that enables the synthesis of a complement strand of DNA by binding to it and acting as a point of transcription initiation.
""" ;
  rdfs:seeAlso sio:DeoxyribonucleicAcid ;
  rdfs:subClassOf sio:Primer .

sio:DeoxyribonucleicAcidSequence a owl:Class ;
  rdfs:comment """A deoxyribonucleic acid sequence is a symbolic representation of the sequence of deoxyribonucleic acid residues in a deoxyribonucleic acid.
""" ;
  rdfs:subClassOf sio:NucleicAcidSequence .

sio:DeoxyribonucleicAcidTemplate a owl:Class ;
  rdfs:comment """A deoxyribonucleic acid template is a deoxyribonucleic acid that provides the template to synthesize a complementary strand of DNA through transcription.
""" ;
  rdfs:subClassOf sio:DeoxyribonucleicAcid .

sio:DeoxyribonucleotideResidue a owl:Class ;
  rdfs:comment """A deoxyribonucleotide residue is a part of a molecule that derives from a deoxyribonucleotide.
""" ;
  rdfs:subClassOf sio:NucleotideResidue .

sio:DepartmentChairRole a owl:Class ;
  rdfs:comment """A department chain role is the role of an individual that heads a department at a academic organization.
""" ;
  rdfs:subClassOf sio:AcademicRole .

sio:DependentVariable a owl:Class ;
  rdfs:comment """A dependent variable is one whose value changes as a consequence of changes in other values in the system.
""" ;
  rdfs:subClassOf sio:Variable .

sio:Depression a owl:Class ;
  rdfs:comment """depression is an unpleasant emotion linked to aversion to activity that can affect a person's thoughts, behavior, feelings and physical well-being. Depressed individuals may feel sad, anxious, empty, hopeless, worried, helpless, worthless, guilty, irritable, or restless.
""" ;
  rdfs:subClassOf sio:Sadness .

sio:Depth a owl:Class ;
  rdfs:comment "depth is the dimensional extent into a plane of a 3D projection of the object." ;
  rdfs:subClassOf sio:1DExtentQuantity .

sio:Description a owl:Class ;
  rdfs:comment """A description is language entity in which elements of a language (formal or natural) are used to characterize an entity.
""" ;
  rdfs:subClassOf sio:LanguageEntity .

sio:Descriptor a owl:Class ;
  rdfs:comment """A descriptor (index term, subject term, subject heading) is a term that captures the essence of the topic of a document.
""" ;
  rdfs:subClassOf sio:Term .

sio:Design a owl:Class ;
  rdfs:comment """A specification of an object, manifested by an agent, intended to accomplish goals, in a particular environment, using a set of primitive components, satisfying a set of requirements, subject to constraints.
""" ;
  rdfs:subClassOf sio:FunctionalSpecification .

sio:DesignSpecification a owl:Class ;
  rdfs:comment """A design specification is a specification that provides precise and explicit information about the requirements for a product design.
""" ;
  rdfs:subClassOf sio:FunctionalSpecification .

sio:Desire a owl:Class ;
  rdfs:comment """desire is a strong emotion of wanting to have something or wishing for something to happen.
""" ;
  rdfs:subClassOf sio:Interest .

sio:Despair a owl:Class ;
  rdfs:comment "despair is depression, hopelessness or lack of hope." ;
  rdfs:subClassOf sio:Sadness .

sio:Destroying a owl:Class ;
  rdfs:comment """destroying is a process in which something is broken down and/or ceases to exist.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:Device a owl:Class ;
  rdfs:comment "A device is usually a constructed tool." ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:Diagnosis a owl:Class ;
  rdfs:comment """A diagnosis is the result of a medical investigation to identify a disorder from its signs and symptoms.
""" ;
  rdfs:subClassOf sio:Conclusion .

sio:DiagnosticOpinion a owl:Class ;
  rdfs:comment """A diagnostic opinion is an opinion resulting from a medical diagnostic procedure.
""" ;
  rdfs:subClassOf sio:Opinion .

sio:DiagnosticTest a owl:Class ;
  rdfs:comment """A diagnostic test is a procedure performed to confirm, or determine the presence of disease in an individual suspected of having the disease, usually following the report of symptoms, or based on the results of other medical tests.
""" ;
  rdfs:subClassOf sio:MedicalProcedure .

sio:Diamond a owl:Class ;
  rdfs:comment """diamond is a carbon allotrope in which each carbon atom in diamond is covalently bonded to four other carbons in a tetrahedron. These tetrahedrons together form a 3-dimensional network of puckered six-membered rings of atoms.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:Diary a owl:Class ;
  rdfs:comment "A diary is a document which describes day-to-day experiences." ;
  rdfs:subClassOf sio:Document .

sio:Diastereomer a owl:Class ;
  rdfs:comment "A diastereomer is a stereoisomer that is not a mirror image of its isomer." ;
  rdfs:subClassOf sio:Stereoisomer .

sio:DifferenceInNumberOfObjectsProduced a owl:Class ;
  rdfs:comment """A difference in number of objects produced is a count of the number of objects produced with respect to a second variable (space, time, etc)
""" ;
  rdfs:subClassOf sio:Count .

sio:DifferentialDiagnosis a owl:Class ;
  rdfs:comment """A differential diagnosis (sometimes abbreviated DDx, ddx, DD, D/Dx, or ΔΔ) is a systematic diagnostic method used to identify the presence of an entity where multiple alternatives are possible (and the process may be termed differential diagnostic procedure), and may also refer to any of the included candidate alternatives (which may also be termed candidate condition).
""" ;
  rdfs:subClassOf sio:MedicalProcedure .

sio:DifferentialEquation a owl:Class ;
  rdfs:comment """A differential equation is a mathematical equation for an unknown function of one or several variables that relates the values of the function itself and its derivatives of various orders.
""" ;
  rdfs:subClassOf sio:Equation .

sio:DifferentialGeneExpressionRatio a owl:Class ;
  rdfs:comment """A differential gene expression ratio is the ratio of gene expression values from a test sample compared to a control sample.
""" ;
  rdfs:subClassOf sio:Ratio .

sio:Diffusion a owl:Class ;
  rdfs:comment "diffusion is motion of particles at temperatures above absolute zero." ;
  rdfs:subClassOf sio:PassiveMovement .

sio:DiffusionEquation a owl:Class ;
  rdfs:comment """A diffusion equation describes density fluctuations in a material undergoing diffusion.
""" ;
  rdfs:subClassOf sio:MovementEquation .

sio:DimensionalQuantity a owl:Class ;
  rdfs:comment "A dimensional quantity is a quantity that has an associated unit." ;
  rdfs:subClassOf sio:Quantity .

sio:DimensionlessQuantity a owl:Class ;
  rdfs:comment "A dimensionless quantity is a quantity that has no associated unit." ;
  rdfs:subClassOf sio:Quantity .

sio:DipoleDipoleInteraction a owl:Class ;
  rdfs:comment """A dipole-dipole interaction is a weak submolecular interaction between strongly electronegative atoms.
""" ;
  rdfs:subClassOf sio:WeakSubmolecularComponent .

sio:DirectedAcyclicGraph a owl:Class ;
  rdfs:comment """a directed acyclic graph or DAG is a network digram that contains directed edges in which nodes may have multiple parents, but there are no cycles.
""" ;
  rdfs:subClassOf sio:NetworkDiagram .

sio:DirectedLineSegment a owl:Class ;
  rdfs:comment """A directed line segment is a line segment that is contained by an ordered pair 
of endpoints (a start point and an endpoint).
""" ;
  rdfs:subClassOf sio:LineSegment .

sio:DisGeNetDiseaseSpecificity a owl:Class ;
  rdfs:comment """DisGeNET Disease specificity is a measure of disease coverage. It is calculated from the negative base 2 log of the ratio of number of diseases associated to the total number of diseases.

The measure is described here: http://www.disgenet.org/web/DisGeNET/menu/dbinfo#specificity
""" ;
  rdfs:subClassOf sio:Ratio .

sio:DisGeNetPleiotropyIndex a owl:Class ;
  rdfs:comment """The DisGeNET pleiotropy index is a measure of specificity as it pertains to classes of disease. The disease pleotropy index is computed from the ratio of the number of disease classes associated with an entity over the total number of disease classes multplied by 100. 

The measure is defined here: http://www.disgenet.org/web/DisGeNET/menu/dbinfo#pleiotropy
""" ;
  rdfs:subClassOf sio:Ratio .

sio:Disagreement a owl:Class ;
  rdfs:comment """agreement is the result of consensus decision making when members of the group do not all agree.
""" ;
  rdfs:subClassOf sio:AgreementQuality .

sio:Disappointment a owl:Class ;
  rdfs:comment """disappointment is the feeling of dissatisfaction that follows the failure of expectations or hopes to manifest.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Discouragement a owl:Class ;
  rdfs:comment "Discouragement is the emtion of having lost confidence or enthusiasm." ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:DiscussionSection a owl:Class ;
  rdfs:comment """The discussion section is a document section containing a summary of the findings, a reflection on the significance of findings, comparison with related work, among others.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:Disease a owl:Class ;
  rdfs:comment "disease is the outward manifestation of one or more disorders." ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:Disgust a owl:Class ;
  rdfs:comment """Disgust is a feeling of revulsion or profound disapproval aroused by something unpleasant or offensive.
""" ;
  rdfs:subClassOf sio:Hostility .

sio:Disjunctionor a owl:Class ;
  rdfs:comment """OR is a logical operator that results in true whenever one or more of its operands are true.
""" ;
  rdfs:subClassOf sio:LogicalOperator .

sio:Disordered a owl:Class ;
  rdfs:comment """disordered is a structural quality in which the parts of an object are non-rigid.
""" ;
  rdfs:subClassOf sio:StructuralQuality .

sio:DisplacementReaction a owl:Class ;
  rdfs:comment """A displacement reaction is an inorganic reaction in which a elementary substance displaces and sets free a constituent atom from a molecule.
""" ;
  rdfs:subClassOf sio:InorganicReaction .

sio:Disposition a owl:Class ;
  rdfs:comment """A disposition is the tendency of a capability to be exhibited under certain conditions or in response to a certain stimulus (trigger).
""" ;
  rdfs:subClassOf sio:Capability , [
    a owl:Restriction ;
    owl:onProperty sio:is_disposition_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_disposition_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:DissatisfiedQualifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:SatisfactionQualifier .

sio:DisulfideBond a owl:Class ;
  rdfs:comment "A disulfide bond is a bond between two sulfur atoms." ;
  rdfs:subClassOf sio:SingleBond .

sio:DnaGene a owl:Class ;
  rdfs:comment "A gene that is located on DNA." ;
  rdfs:subClassOf sio:Gene .

sio:Doctor a owl:Class ;
  rdfs:comment """A doctor is an individual who practices medicine, which is concerned with promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury, and other physical and mental impairments.
""" ;
  rdfs:subClassOf sio:MedicalPractitioner .

sio:DoctorRole a owl:Class ;
  rdfs:comment """A doctor role is the role of an individual who practices medicine, which is concerned with promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury, and other physical and mental impairments.
""" ;
  rdfs:subClassOf sio:MedicalRole .

sio:Document a owl:Class ;
  rdfs:comment """A document is a bounded physical or digital representation of a body of information designed with the capacity (and usually intent) to communicate.
""" ;
  rdfs:subClassOf sio:TextualEntity .

sio:DocumentComponent a owl:Class ;
  rdfs:comment "A bibliographic attribute is an attribute related to publications." ;
  rdfs:subClassOf sio:TextualEntity .

sio:DocumentSection a owl:Class ;
  rdfs:comment "A document section is a component of a document." ;
  rdfs:subClassOf sio:DocumentComponent .

sio:DocumentTitle a owl:Class ;
  rdfs:comment """A document title is a textual entity that summarizes the topic of the document in one sentence.
""" ;
  rdfs:subClassOf sio:Title .

sio:DocumentVersion a owl:Class ;
  rdfs:comment "A document version is a version of a work in some sequence of derivative works." ;
  rdfs:subClassOf sio:VersionLabel .

sio:Dose a owl:Class ;
  rdfs:comment """A dose is the quantity of a chemical substance administered to a biological system.
""" ;
  rdfs:subClassOf sio:DimensionalQuantity .

sio:DoubleArrowedLineSegment a owl:Class ;
  rdfs:comment """A double arrowed line is an arrowed line in which both terminal points are  tangentially part of different triangles that bisect the line.
""" ;
  rdfs:subClassOf sio:ArrowedLineSegment .

sio:DoubleBond a owl:Class ;
  rdfs:comment """A double bond is a covalent bond between a pair of atoms in which two pairs of electrons are shared.
""" ;
  rdfs:subClassOf sio:CovalentBond .

sio:DoubleDisplacementReaction a owl:Class ;
  rdfs:comment """A double displacement reaction is a displacement reaction in which two molecules swap ions, effectively displacing each other to form two new molecules.
""" ;
  rdfs:subClassOf sio:DisplacementReaction .

sio:DoubleStrandedDna a owl:Class ;
  rdfs:comment """double stranded nucleic acid is a molecular complex composed of two weakly connected deoxyribonucleic acids.
""" ;
  rdfs:subClassOf sio:DoubleStrandedNucleicAcid .

sio:DoubleStrandedNucleicAcid a owl:Class ;
  rdfs:comment """double stranded nucleic acid is a molecular complex composed of two weakly connected nucleic acids.
""" ;
  rdfs:subClassOf sio:MolecularComplex .

sio:DoubleStrandedRna a owl:Class ;
  rdfs:comment """double stranded nucleic acid is a molecular complex composed of two weakly connected ribonucleic acids.
""" ;
  rdfs:subClassOf sio:DoubleStrandedNucleicAcid .

sio:Draft a owl:Class ;
  rdfs:comment "draft is the quality of text that has not yet complete." ;
  rdfs:subClassOf sio:Written .

sio:Dread a owl:Class ;
  rdfs:comment "dread is the instense negative emotion that induces fear and apprehension." ;
  rdfs:subClassOf sio:Fear .

sio:DropLine a owl:Class ;
  rdfs:comment """A drop line is a statistical graph line that vertically or horizontally connects a data series line with a value axis in a statistical graph.
""" ;
  rdfs:subClassOf sio:StatisticalGraphLine .

sio:Drug a owl:Class ;
  rdfs:comment """A drug is a chemical substance that contains one or more active ingredients that regulate one or more biological processes.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:DrugDrugInteraction a owl:Class ;
  rdfs:comment """A drug-drug interaction is an interaction in which two drugs interact in such a way to produce a non-additive biological response.
""" ;
  rdfs:subClassOf sio:ChemicalEffect .

sio:DrugRegulatoryAuthority a owl:Class ;
  rdfs:comment """A drug regulatory authority is a regulatory authority which acts to control what substances may be used to treat individuals.
""" ;
  rdfs:subClassOf sio:RegulatoryAuthority .

sio:DubniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Duplicate a owl:Class ;
  rdfs:comment "a duplicate is an object that is an exact copy of another item" ;
  rdfs:subClassOf sio:CollectionItem .

sio:DuplicateRole a owl:Class ;
  rdfs:comment """a duplicate role is a comparative role that holds when one item is an exact copy of another in a specific set.
""" ;
  rdfs:subClassOf sio:ComparativeRole .

sio:Dying a owl:Class ;
  rdfs:comment "dying is a process in which a biological entity ceases to exist." ;
  rdfs:subClassOf sio:Destroying .

sio:Dysfunction a owl:Class ;
  rdfs:comment """dysfunction is a capability to act in a manner that is abnormal or opposite  to the object's typical function.
""" ;
  rdfs:subClassOf sio:Capability .

sio:DysprosiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:EColi a owl:Class ;
  rdfs:comment """Escherichia coli (e coli) is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms.
""" ;
  rdfs:subClassOf sio:UnicellularOrganism .

sio:Ecstasy a owl:Class ;
  rdfs:comment """ecstacy is an emotion characterized by a heightened state of consciousness with total involvement of a subject.
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:Edge a owl:Class ;
  rdfs:comment "an edge is a line connecting two graph vertices." ;
  rdfs:subClassOf sio:Line .

sio:EditedPublication a owl:Class ;
  rdfs:comment """An edited publication is a publication that has been examined and potentially changed by an editor.
""" ;
  rdfs:subClassOf sio:Publication .

sio:EditionNumber a owl:Class ;
  rdfs:comment """An edition number is count of a literary work edited and published, as by a certain editor or in a certain manner including being printed during some interval of time.
""" ;
  rdfs:subClassOf sio:Count .

sio:EditorReviewed a owl:Class ;
  rdfs:comment """editor reviewed is the quality of a textual entity that has been examined and commented on by an editor.
""" ;
  rdfs:subClassOf sio:Reviewed .

sio:EffectiveDose a owl:Class ;
  rdfs:comment """effective dose is the amount of a substance required to produce an effect on a predefined percentage of a population.
""" ;
  rdfs:subClassOf sio:Dose .

sio:EinsteiniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:ElectronicStructure a owl:Class ;
  rdfs:comment """electronic structure is the electron configuration is the distribution of electrons of an atom or molecule (or other physical structure) in atomic or molecular orbitals.
""" ;
  rdfs:subClassOf sio:ChemicalStructure .

sio:ElectrophilicAdditionReaction a owl:Class ;
  rdfs:comment """An electrophilic addition reaction is a polar addition reaction where a pi bond is removed by the creation of two new covalent bonds.
""" ;
  rdfs:subClassOf sio:PolarAdditionReaction .

sio:Email a owl:Class ;
  rdfs:comment """Email message is a digital document that is composed of a header and a body and is transmitted using the SMTP protocol.
""" ;
  rdfs:subClassOf sio:Document .

sio:EmailAddress a owl:Class ;
  rdfs:comment "an email address is an identifier to send mail to particular electronic mailbox." ;
  rdfs:subClassOf sio:InformationalEntityIdentifier .

sio:Embarassment a owl:Class ;
  rdfs:comment """Embarrassment is the emotion of intense discomfort with oneself, experienced upon having a socially unacceptable act or condition witnessed by or revealed to other.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Emotion a owl:Class ;
  rdfs:comment """An emotion is a process (experience) that arises internally or from an involuntary physiological response to a stimulus.
""" ;
  rdfs:subClassOf sio:Behaviour .

sio:Empty a owl:Class ;
  rdfs:comment "empty is the quality of not containing some thing" ;
  rdfs:subClassOf sio:ContainmentQuality .

sio:EmptySet a owl:Class ;
  rdfs:comment "An empty set is a set for which there are exactly 0 members." ;
  rdfs:subClassOf sio:Set .

sio:Enantiomer a owl:Class ;
  rdfs:comment "An enantiomer is a stereoisomer that is a mirror image of its isomer." ;
  rdfs:subClassOf sio:Stereoisomer .

sio:EndDate a owl:Class ;
  rdfs:comment "An end date is a time instant pertaining to date of the end of a process." ;
  rdfs:subClassOf sio:TimeInstant .

sio:EndPosition a owl:Class ;
  rdfs:comment """An end position is the distal position of an object relative to an origin in a linear system.
""" ;
  rdfs:subClassOf sio:LinearPosition .

sio:EndTime a owl:Class ;
  rdfs:comment "An end time is a time instant pertaining to the time at which a process ends." ;
  rdfs:subClassOf sio:TimeInstant .

sio:Endpoint a owl:Class ;
  rdfs:comment """An endpoint is a terminal point that is the last of an ordered 
pair of points.
""" ;
  rdfs:subClassOf sio:TerminalPoint .

sio:Entity a owl:Class ;
  rdfs:comment "Every thing is an entity." ;
  rdfs:subClassOf [
    a owl:Restriction ;
    owl:onProperty sio:has_creator ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_creator ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_attribute ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_attribute ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:satisfies ;
    owl:allValuesFrom sio:Description
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:satisfies ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_related_to ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_related_to ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Environment a owl:Class ;
  rdfs:comment "An environment is a geographic region that hosts certain processes or objects." ;
  rdfs:subClassOf sio:GeographicRegion .

sio:Envy a owl:Class ;
  rdfs:comment """envy is an emotion that occurs when a person lacks another's (perceived) superior quality, achievement or possession and wishes that the other lacked it.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Enzyme a owl:Class ;
  rdfs:comment """An enzyme is a protein or protein complex that realizes its disposition to covalently modify some molecule during a chemical reaction.
""" ;
  rdfs:subClassOf sio:Protein .

sio:Epimer a owl:Class ;
  rdfs:comment """An epimer is a stereoisomer that differs in configuration at only one stereogenic center.
""" ;
  rdfs:subClassOf sio:Stereoisomer .

sio:EpimerAssociation a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Association .

sio:Equation a owl:Class ;
  rdfs:comment """An equation is a mathematical statement that asserts the equality of two expressions.
""" ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:ErbiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:EthnicGroup a owl:Class ;
  rdfs:comment """An ethnic group is a group of people whose members identify with each other through a common heritage, consisting of a common culture, including a shared language or dialect. 
""" ;
  rdfs:subClassOf sio:HumanPopulation .

sio:Ethnicity a owl:Class ;
  rdfs:comment """ethnicity is the biological quality of membership in a social group based on a common heritage.
""" ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:Euphoria a owl:Class ;
  rdfs:comment """euphoria is an emotion characterized by intense feelings of well-being, elation, happiness, ecstasy, excitement, and joy.
""" ;
  rdfs:subClassOf sio:Happiness .

sio:EuropiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:EvaluationRole a owl:Class ;
  rdfs:comment """An evaluation role is a processual role held by an entity during some evaluation.
""" ;
  rdfs:subClassOf sio:InvestigationalRole .

sio:Evidence a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Proposition .

sio:EvolutionaryLineage a owl:Class ;
  rdfs:comment """evolutionary lineage is a sequence of species, that form a line of descent, each new species the direct result of speciation from an immediate ancestral species.
""" ;
  rdfs:subClassOf sio:History .

sio:Evolving a owl:Class ;
  rdfs:comment """evolving is a process that elicits change across successive generations in the inherited characteristics of biological populations.
""" ;
  rdfs:subClassOf sio:Creating .

sio:ExactCrossReference a owl:Class ;
  rdfs:comment """An exact cross-reference is a database cross-reference in which one entity is equivalent to the other based on all the entitie's attributes (minus the source).
""" ;
  rdfs:subClassOf sio:DatabaseCrossReference .

sio:ExcellentQuality a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QualityDescriptor .

sio:Excerpt a owl:Class ;
  rdfs:comment "An excerpt is a contiguous or discontiguous portion of a document." ;
  rdfs:subClassOf sio:TextualEntity .

sio:Excitement a owl:Class ;
  rdfs:comment "excitement is a positive emotion of feeling great enthusiasm and eagerness." ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:ExclusionCriterion a owl:Class ;
  rdfs:comment """An exclusion criterion is a criterion that must be absent to satistify the objective.
""" ;
  rdfs:subClassOf sio:Criterion .

sio:ExclusiveDisjunctionxor a owl:Class ;
  rdfs:comment """XOR, also called exclusive disjunction or (symbolized XOR, EOR, EXOR, or ⊕), is a type of logical disjunction on two operands that results in a value of true if exactly one of the operands has a value of true.
""" ;
  rdfs:subClassOf sio:Disjunctionor .

sio:ExistenceQuality a owl:Class ;
  rdfs:comment """existence quality is the quality of an entity that describe in what environment it is known to exist.
""" ;
  rdfs:subClassOf sio:Quality .

sio:Exon a owl:Class ;
  rdfs:comment """An exon is a nucleotide sequence encoded by a gene that remains present within the final mature RNA product of that gene after introns have been removed by RNA splicing. 
""" ;
  rdfs:subClassOf sio:GeneComponent .

sio:ExpectedValue a owl:Class ;
  rdfs:comment """An expected value (or e-value) is the weighted average of all possible values that a random variable can take on.
""" ;
  rdfs:subClassOf sio:ProbabilityMeasure .

sio:Experiment a owl:Class ;
  rdfs:comment """An experiment is an investigation that has the goal of verifying, falsifying, or establishing the validity of a hypothesis. 
""" ;
  rdfs:subClassOf sio:Investigation .

sio:ExperimentalProtocol a owl:Class ;
  rdfs:comment """An experimental protocol is an action specification with respect to the design and implementation of experiments. In addition to providing a detailed set of procedures and lists of required equipment and instruments, experimental protocols often include information on safety precautions, the calculation of results and reporting standards, including statistical analysis and rules for predefining and documenting excluded data to avoid bias.
""" ;
  rdfs:subClassOf sio:ActionSpecification .

sio:False a owl:Class ;
  rdfs:comment "false is a truth value in that indicates that it is not true." ;
  rdfs:subClassOf sio:TruthValue .

sio:Family a owl:Class ;
  rdfs:comment "A group of people affiliated by consanguinity, affinity, or co-residence." ;
  rdfs:subClassOf sio:Collective .

sio:FamilyHistory a owl:Class ;
  rdfs:comment """family history is the systematic narrative and research of past events relating to a specific family, or specific families.
""" ;
  rdfs:subClassOf sio:History .

sio:Fatal a owl:Class ;
  rdfs:comment """fatal is a qualitative intensity value that is more intense than severe, leading to the death/non-functioning of a system.
""" ;
  rdfs:subClassOf sio:Intensity .

sio:FaxNumber a owl:Class ;
  rdfs:comment "a fax number is a number to connect to fax device" ;
  rdfs:subClassOf sio:TelephoneNumber .

sio:Fear a owl:Class ;
  rdfs:comment """Fear is a negative emotion induced by a perceived threat that induces one to hide or move quickly away from the location of the perceived threat.
""" ;
  rdfs:subClassOf sio:Apprehension .

sio:Female a owl:Class ;
  rdfs:comment "female is a biological sex of an individual with female sexual organs." ;
  rdfs:subClassOf sio:BiologicalSex .

sio:FermiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Fictional a owl:Class ;
  rdfs:comment """fictional is the quality of an entity that exists only in a creative work of fiction.
""" ;
  rdfs:subClassOf sio:Hypothetical .

sio:Figure a owl:Class ;
  rdfs:comment """A figure is a graphical entity which consists of a visual (n-dimentional) arrangement of information entities.
""" ;
  rdfs:subClassOf sio:Media .

sio:FigurePart a owl:Class ;
  rdfs:comment "A figure part is a part of a figure." ;
  rdfs:subClassOf sio:Media .

sio:File a owl:Class ;
  rdfs:comment """A file is an information-bearing object that contains a physical embodiment of some information using a particular character encoding.
""" ;
  rdfs:subClassOf sio:Media .

sio:Finalized a owl:Class ;
  rdfs:comment "finalized is the quality of a textual entity that is in its final form." ;
  rdfs:subClassOf sio:Written .

sio:FirstName a owl:Class ;
  rdfs:comment """A first name is a name that denotes a specific individual between members of a group of individuals, whose members usually share the same surname.
""" ;
  rdfs:subClassOf sio:Name .

sio:Fitness a owl:Class ;
  rdfs:comment """fitness is the quality of an object with respect to some stated functions or evolutionary adaptation.
""" ;
  rdfs:subClassOf sio:ObjectQuality .

sio:Flowchart a owl:Class ;
  rdfs:comment """A flowchart is a diagram that represents an algorithm or process, showing the steps as boxes of various kinds, and their order by connecting these with arrows.
""" ;
  rdfs:subClassOf sio:Chart .

sio:FluorineAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:ForeignDatabaseKey a owl:Class ;
  rdfs:comment "A foreign database key is a database key that refers to a key in some table." ;
  rdfs:subClassOf sio:DatabaseKey .

sio:FormalSpecification a owl:Class ;
  rdfs:comment """A formal specification is a mathematical description of software or hardware that may be used to develop an implementation.
""" ;
  rdfs:subClassOf sio:FunctionalSpecification .

sio:FranciumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:FreeRadicalAddition a owl:Class ;
  rdfs:comment """A free radical addition is a non-polar addition reaction involving free radicals.
""" ;
  rdfs:subClassOf sio:NonPolarAdditionReaction .

sio:Frequency a owl:Class ;
  rdfs:comment "Frequency is the number of occurrences of a repeating event per unit time" ;
  rdfs:subClassOf sio:RateOfChange .

sio:Frustration a owl:Class ;
  rdfs:comment """Frustration is an emotion that arises from the perceived resistance to the fulfillment of individual will. 
""" ;
  rdfs:subClassOf sio:Annoyance .

sio:Full a owl:Class ;
  rdfs:comment """full is the quality of contain an entity such that there is no more space for any additional entity.
""" ;
  rdfs:subClassOf sio:ContainmentQuality .

sio:FullAgreement a owl:Class ;
  rdfs:comment """full agreement is the result of consensus decision making when members of the group unanimously agree.
""" ;
  rdfs:subClassOf sio:Agreement .

sio:FullDisagreement a owl:Class ;
  rdfs:comment """full agreement is the result of consensus decision making when members of the group unanimously disagree.
""" ;
  rdfs:subClassOf sio:Disagreement .

sio:Fullerene a owl:Class ;
  rdfs:comment """fullerene is a carbon allotrope which take the form of a hollow sphere, ellipsoid, or tube.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:Function a owl:Class ;
  rdfs:comment """A function is a capability that satisfies some agentive objective, or (evolutionary) optimization.
""" ;
  rdfs:subClassOf sio:Capability , [
    a owl:Restriction ;
    owl:onProperty sio:is_function_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_function_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:FunctionalRnaCodingGene a owl:Class ;
  rdfs:comment "A gene that codes for a functional RNA molecule." ;
  rdfs:subClassOf sio:RnaGene .

sio:FunctionalSpecification a owl:Class ;
  rdfs:comment """A functional specification is a specification that describes the characteristics of an object.
""" ;
  rdfs:subClassOf sio:Specification .

sio:FusionGeneDiseaseAssociation a owl:Class ;
  rdfs:comment """A gene-disease association in which the fusion between two different genes (promotor and/or other coding DNA regions) is associated with the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithGenomicAlterations .

sio:GadoliniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:GalliumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:GanttChart a owl:Class ;
  rdfs:comment "A Gantt chart is a bar chart that illustrates a project schedule." ;
  rdfs:subClassOf sio:Chart .

sio:Gene a owl:Class ;
  rdfs:comment """A gene is part of a nucleic acid that contains all the necessary elements to encode a functional transcript.
""" ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:GeneDiseaseAssociation a owl:Class ;
  rdfs:comment "A gene-disease association is an association between a gene and a disease." ;
  rdfs:subClassOf sio:Association .

sio:GeneDiseaseAssociationLinkedWithAlteredGeneExpression a owl:Class ;
  rdfs:comment """A gene-disease association in which the disease phenotype is associated with an altered expression of the gene.
""" ;
  rdfs:subClassOf sio:GeneDiseaseBiomarkerAssociation .

sio:GeneDiseaseAssociationLinkedWithCausalMutation a owl:Class ;
  rdfs:comment """A gene-variant disease association in which a mutation in the gene/protein results in the development or maintenance of the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithGeneticVariation .

sio:GeneDiseaseAssociationLinkedWithChromosomalRearrangement a owl:Class ;
  rdfs:comment """A gene-disease association in which the gene is included in a chromosomal rearrangement associated with a particular manifestation of the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithGenomicAlterations .

sio:GeneDiseaseAssociationLinkedWithGeneticVariation a owl:Class ;
  rdfs:comment """A gene-disease association in which a sequence variation (a mutation, a SNP) is associated with the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithGenomicAlterations .

sio:GeneDiseaseAssociationLinkedWithGenomicAlterations a owl:Class ;
  rdfs:comment "a gene-disease association that is linked with some genomic alteration" ;
  rdfs:subClassOf sio:GeneDiseaseBiomarkerAssociation .

sio:GeneDiseaseAssociationLinkedWithGermlineCausalMutation a owl:Class ;
  rdfs:comment """A gene-variant disease association in which a germline mutation in the gene/protein results in the development or maintenance of the disease, and it may be passed on to offspring.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithCausalMutation .

sio:GeneDiseaseAssociationLinkedWithGermlineModifyingMutation a owl:Class ;
  rdfs:comment """A gene-variant disease association in which a germline mutation in the gene modifies the clinical presentation of the disease, and it may be passed on to offspring.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithModifyingMutation .

sio:GeneDiseaseAssociationLinkedWithModifyingMutation a owl:Class ;
  rdfs:comment """A gene-disease association in which a gene mutation is known to modify the clinical presentation of the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithGeneticVariation .

sio:GeneDiseaseAssociationLinkedWithPostTranslationalModification a owl:Class ;
  rdfs:comment """A gene-disease association in which the disease phenotype is associated with post-translational modifications in the protein product.
""" ;
  rdfs:subClassOf sio:GeneDiseaseBiomarkerAssociation .

sio:GeneDiseaseAssociationLinkedWithSomaticCausalMutation a owl:Class ;
  rdfs:comment """A gene-variant disease association in which a somatic mutation in the gene/protein results in the development or maintenance of the disease, and it may not be passed on to offspring.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithCausalMutation .

sio:GeneDiseaseAssociationLinkedWithSomaticModifyingMutation a owl:Class ;
  rdfs:comment """A gene-variant disease association in which a somatic mutation in the gene modifies the clinical presentation of the disease, and it may not be passed on to offspring.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithModifyingMutation .

sio:GeneDiseaseAssociationLinkedWithSusceptibilityMutation a owl:Class ;
  rdfs:comment """A gene-disease association in which a germline mutation in the gene predisposes to the development of the disease, and it is necessary but not sufficient for the manifestation of the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociationLinkedWithGeneticVariation .

sio:GeneDiseaseBiomarkerAssociation a owl:Class ;
  rdfs:comment """A gene-disease association in which the gene/protein is involved in the etiology or maintenance of the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociation .

sio:GeneComponent a owl:Class ;
  rdfs:comment "A gene component is a component of a gene." ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:GeneEnhancer a owl:Class ;
  rdfs:comment """A gene enhancer is a short region of DNA that can be bound with proteins to enhance transcription levels of genes in a gene cluster.
""" ;
  rdfs:subClassOf sio:GeneRegulatoryComponent .

sio:GeneExpressionValue a owl:Class ;
  rdfs:comment """A gene expression value is a measured value obtained from a gene expression experiment.
""" ;
  rdfs:subClassOf sio:DimensionalQuantity .

sio:GenePromoter a owl:Class ;
  rdfs:comment """A gene promoter is a region of DNA that initiates transcription of a particular gene.
""" ;
  rdfs:subClassOf sio:GeneRegulatoryComponent .

sio:GeneRegulatoryComponent a owl:Class ;
  rdfs:comment """A gene regulatory component is a gene component that exerts a regulatory function.
""" ;
  rdfs:subClassOf sio:GeneComponent .

sio:GeneSymbol a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:ScientificName .

sio:GenerationNumber a owl:Class ;
  rdfs:comment """generation number is a count of the number of biological reproduction events elapsed from some starting reference point.
""" ;
  rdfs:subClassOf sio:Count .

sio:GenericName a owl:Class ;
  rdfs:comment "A generic name is the preferred name provided by manufacturer." ;
  rdfs:subClassOf sio:Name .

sio:GeneticData a owl:Class ;
  rdfs:comment "genetic data is data pertaining to genetics." ;
  rdfs:subClassOf sio:BiologicalData .

sio:GeneticPolymorphism a owl:Class ;
  rdfs:comment """genetic polymorphism is the description of a difference in genetic composition at some location.
""" ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Genome a owl:Class ;
  rdfs:comment "A genome is a collection of nucleic acids." ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:GenomicSequenceVariant a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Genotype a owl:Class ;
  rdfs:comment """A genotype is a functional specification of a biological entity in terms of its genetic composition (or lack thereof).
""" ;
  rdfs:subClassOf sio:FunctionalSpecification .

sio:GeographicHeatmap a owl:Class ;
  rdfs:comment """A geographic heatmap is a graphical representation of data over a geographic region where individual values are represented as colors.
""" ;
  rdfs:subClassOf sio:Heatmap .

sio:GeographicImage a owl:Class ;
  rdfs:comment "A geographic image is a photograph of some geographical area." ;
  rdfs:subClassOf sio:Photograph .

sio:GeographicPosition a owl:Class ;
  rdfs:comment """A geographic position is the coordinate of an entity against some geographic coordinate system.
""" ;
  rdfs:subClassOf sio:Position .

sio:GeographicRegion a owl:Class ;
  rdfs:comment """A geographic region is a spatial region whose boundaries are typically defined against some material frame of reference (like the earth).
""" ;
  rdfs:subClassOf sio:SpatialRegion .

sio:GeolegalRegion a owl:Class ;
  rdfs:comment """A geolegal region is a geographic region which has causal powers confered by a legal entity.
""" ;
  rdfs:subClassOf sio:GeographicRegion .

sio:GeometricEntity a owl:Class ;
  rdfs:comment """A geometric entity is an information content entity that pertains to the structure and topology of a space.
""" ;
  rdfs:subClassOf sio:InformationContentEntity .

sio:GeopoliticalRegion a owl:Class ;
  rdfs:comment """a geopolitical region is a geographic region recognized by social or legal convention.
""" ;
  rdfs:subClassOf sio:GeolegalRegion .

sio:GermaniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Gesturing a owl:Class ;
  rdfs:comment """gesturing is a form of non-verbal communication in which visible bodily actions communicate particular messages, either in place of speech or together and in parallel with spoken words. Gestures include movement of the hands, face, or other parts of the body.
""" ;
  rdfs:subClassOf sio:Communicating .

sio:GlassyCarbon a owl:Class ;
  rdfs:comment """glassy carbon is an allotrope of carbon which is widely used as an electrode material in electrochemistry, as well as for high temperature crucibles and as a component of some prosthetic devices.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:GlobalMaximalStationaryPoint a owl:Class ;
  rdfs:comment """A global maximum stationary point is a data point that corresponds to a measurement value is larger than that of all other plotted datapoints.
""" ;
  rdfs:subClassOf sio:LocalMaximumStationaryPoint .

sio:GlobalMinimalStationaryPoint a owl:Class ;
  rdfs:comment """A global minimum data point is a data point that corresponds to a measurement value is smaller than that of all other plotted datapoints.
""" ;
  rdfs:subClassOf sio:LocalMinimumStationaryPoint .

sio:GoldAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:GoodQuality a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QualityDescriptor .

sio:GraduateStudentAdvisorRole a owl:Class ;
  rdfs:comment """A graduate student advisor role is the role of an individual employed at an academic organization that is involved in advising graduate students.
""" ;
  rdfs:subClassOf sio:StudentAdvisorRole .

sio:GraphTitle a owl:Class ;
  rdfs:comment "A graph title is a title that describes a graph." ;
  rdfs:subClassOf sio:Title .

sio:Graphite a owl:Class ;
  rdfs:comment """graphite is an allotrope of carbon which is a conductor, and is the most stable form of solid carbon.
""" ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:Gratitude a owl:Class ;
  rdfs:comment """Gratitude, thankfulness, gratefulness, or appreciation is a feeling, emotion or attitude in acknowledgment of a benefit that one has received or will receive.
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:Grief a owl:Class ;
  rdfs:comment """grief is an emotion in response to loss, whether physical or abstract including death, unemployment, ill health or the end of a relationship.
""" ;
  rdfs:subClassOf sio:Sadness .

sio:Guilt a owl:Class ;
  rdfs:comment """Guilt is the emotion borne from feeling responsible for the commission of an offense and arises out of public humiliation.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:HafniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Haplotype a owl:Class ;
  rdfs:comment "A haplotype is one of a set of genomic sequence variants." ;
  rdfs:subClassOf sio:GenomicSequenceVariant .

sio:Happiness a owl:Class ;
  rdfs:comment """happiness is an emotion characterized by positive or pleasant emotions ranging from contentment to intense joy.
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:HardDiskDrive a owl:Class ;
  rdfs:comment """A hard disk drive (HDD) is a non-volatile, random access device for digital data. It features rotating rigid platters on a motor-driven spindle within a protective enclosure. Data is magnetically read and written on the platter by read/write heads that float on a film of air above the platters.
""" ;
  rdfs:subClassOf sio:DataStorageDevice .

sio:HassiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Hate a owl:Class ;
  rdfs:comment """Hate is a deep and emotional extreme dislike, directed against a certain object or class of objects. 
""" ;
  rdfs:subClassOf sio:Disgust .

sio:Healthy a owl:Class ;
  rdfs:comment """healthy is an organismal state of complete physical, mental and social well-being.
""" ;
  rdfs:subClassOf sio:Alive .

sio:Heatmap a owl:Class ;
  rdfs:comment """A heatmap is a graphical representation of data where the individual values contained in a matrix are represented as colors.
""" ;
  rdfs:subClassOf sio:Chart .

sio:Height a owl:Class ;
  rdfs:comment """height is the one dimensional extent along the vertical projection of a 3D object from a base plane of reference.
""" ;
  rdfs:subClassOf sio:1DExtentQuantity .

sio:Helicity a owl:Class ;
  rdfs:comment "helicity is the quality of being helical" ;
  rdfs:subClassOf sio:StructuralQuality .

sio:HeliumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Hemizygous a owl:Class ;
  rdfs:comment """hemizygous is the quality of a biological organism in which, based on the ploidy of the organism, there is half the number of alleles than normal at a given locus.
""" ;
  rdfs:subClassOf sio:Zygosity .

sio:Hermaphrodite a owl:Class ;
  rdfs:comment """hermaphrodite is a biological sex of an individual with both male and female sexual organs.
""" ;
  rdfs:subClassOf sio:Intersex .

sio:HeterocyclicRing a owl:Class ;
  rdfs:comment "A heterocyclic ring is a ring containing a hetero atom." ;
  rdfs:subClassOf sio:Ring .

sio:Heterogeneous a owl:Class ;
  rdfs:comment "homogeneous is a quality that describes the varied composition of an object." ;
  rdfs:subClassOf sio:CompositionalQuality .

sio:HeterogeneousSubstance a owl:Class ;
  rdfs:comment """A heterogeneous substance is a chemical substance that is composed of more than one different kind of component.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:Heterozygous a owl:Class ;
  rdfs:comment """homozygous is the quality of a biological organism in which there are two different alleles at a given locus.
""" ;
  rdfs:subClassOf sio:Zygosity .

sio:HgvsNotation a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:SequenceVariationNotation .

sio:Histogram a owl:Class ;
  rdfs:comment """A histogram is a graphical representation of data which consists of tabular frequencies, shown as adjacent rectangles, over discrete intervals (bins) , with an area equal to the frequency of the observations in the interval.
""" ;
  rdfs:subClassOf sio:Chart .

sio:History a owl:Class ;
  rdfs:comment "history is a sequence of past events." ;
  rdfs:subClassOf sio:Description .

sio:Hole a owl:Class ;
  rdfs:comment "A hole is a site that is opening into or through something." ;
  rdfs:subClassOf sio:Site .

sio:HolmiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:HomePhoneNumber a owl:Class ;
  rdfs:comment """a home phone number is the number to connect to an phone at a place of residence.
""" ;
  rdfs:subClassOf sio:TelephoneNumber .

sio:HomocyclicRing a owl:Class ;
  rdfs:comment "A homocyclic ring is a ring where the atoms are of a single type." ;
  rdfs:subClassOf sio:Ring .

sio:Homogeneous a owl:Class ;
  rdfs:comment "homogeneous is a quality that describes the uniform composition of an object." ;
  rdfs:subClassOf sio:CompositionalQuality .

sio:HomogeneousSubstance a owl:Class ;
  rdfs:comment """A homogeneous substance is a substance that is composed of a uniform type of entity.
""" ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:Homonym a owl:Class ;
  rdfs:comment "A homonym is a word that sounds the same but has different meaning." ;
  rdfs:subClassOf sio:TermVariant .

sio:Homozygous a owl:Class ;
  rdfs:comment """homozygous is the quality of a biological organism in which there are two identical alleles at a given locus.
""" ;
  rdfs:subClassOf sio:Zygosity .

sio:Honor27SThesis a owl:Class ;
  rdfs:comment """An honor's thesis is a thesis prepared as a requirement for an honor's undergraduate degree.
""" ;
  rdfs:subClassOf sio:ThesisDocument .

sio:Hope a owl:Class ;
  rdfs:comment """hope is an emotion of belief in a positive outcome related to events and circumstances in one's life.
""" ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:HorizontalBarGraph a owl:Class ;
  rdfs:comment """A horizontal bar graph is a bar graph in which the rectangular bars are horizontally oriented in space.
""" ;
  rdfs:subClassOf sio:BarGraph .

sio:HorizontalLine a owl:Class ;
  rdfs:comment "A horizontal line is a line that is positionally oriented with the horizon." ;
  rdfs:subClassOf sio:PositionallyOrientedLine .

sio:Host a owl:Class ;
  rdfs:comment """A host is an organism that harbors a parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter.
""" ;
  rdfs:subClassOf sio:Organism .

sio:HostRole a owl:Class ;
  rdfs:comment """The role of an organism in providing resources to maintain the survival and/or reproduction of another organism.
""" ;
  rdfs:subClassOf sio:ChemicalSubstanceRole .

sio:Hostility a owl:Class ;
  rdfs:comment """Hostility is the intense negative emotion of being in conflict or opposition to someone or something.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Hour a owl:Class ;
  rdfs:comment "An hour is a period of 60 minutes." ;
  rdfs:subClassOf sio:TimeInterval .

sio:Human a owl:Class ;
  rdfs:comment """A human is a primates of the family Hominidae and are characterized by having a large brain relative to body size, with a well developed neocortex, prefrontal cortex and temporal lobes, making them capable of abstract reasoning, language, introspection, problem solving and culture through social learning.
""" ;
  rdfs:subClassOf sio:MulticellularOrganism .

sio:HumanPopulation a owl:Class ;
  rdfs:comment "A human population refers to a collection of human beings." ;
  rdfs:subClassOf sio:Population .

sio:Humiliation a owl:Class ;
  rdfs:comment """Humiliation is the abasement of pride, which creates mortification or leads to a state of being humbled or reduced to lowliness or submission.
""" ;
  rdfs:subClassOf sio:Hurt .

sio:Hunger a owl:Class ;
  rdfs:comment "hunger is the craving for food." ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Hurt a owl:Class ;
  rdfs:comment "hurt is an unpleasant feeling, emotion or sensation." ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:HydrogenAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:HydrogenBond a owl:Class ;
  rdfs:comment """A hydrogen bond is a weak submolecular interaction formed between a hydrogen atom and a electronegative atom.
""" ;
  rdfs:subClassOf sio:WeakSubmolecularComponent .

sio:Hypernym a owl:Class ;
  rdfs:comment "A hypernym is a term with a broader meaning." ;
  rdfs:subClassOf sio:TermVariant .

sio:Hyponym a owl:Class ;
  rdfs:comment "A hyponym is a term with a narrower meaning." ;
  rdfs:subClassOf sio:TermVariant .

sio:Hypothesis a owl:Class ;
  rdfs:comment "A hypothesis is a proposed explanation for a phenomenon." ;
  rdfs:subClassOf sio:Proposition .

sio:Hypothetical a owl:Class ;
  rdfs:comment "hypothetical is the quality of an entity that is conjectured to exist." ;
  rdfs:subClassOf sio:ExistenceQuality .

sio:Hysteria a owl:Class ;
  rdfs:comment "Hysteria is an unmanageable emotion." ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:IpNumber a owl:Class ;
  rdfs:comment "an IP number is an number to connect to a device on the internet." ;
  rdfs:subClassOf sio:InformationalEntityIdentifier .

sio:Idea a owl:Class ;
  rdfs:comment "An idea is a proposition about some object of conceptual thought." ;
  rdfs:subClassOf sio:Proposition .

sio:Identifier a owl:Class ;
  rdfs:comment """An identifier is a label that specifically refers to (identifies) an entity (instance/type).
""" ;
  rdfs:subClassOf sio:Label , [
    a owl:Restriction ;
    owl:onProperty sio:is_identifier_for ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_identifier_for ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Image a owl:Class ;
  rdfs:comment """An image is an affine projection of a visual entity to a two dimensional surface.
""" ;
  rdfs:subClassOf sio:Figure .

sio:Implies3E a owl:Class ;
  rdfs:comment """Implication is a logical operator that holds between a set T of propositions and a proposition B, when every model (or interpretation or valuation) of T is also a model of B.
""" ;
  rdfs:subClassOf sio:LogicalOperator .

sio:InChiNotation a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:ChemicalNotation .

sio:InactiveIngredient a owl:Class ;
  rdfs:comment """Aninactive ingredient is a molecular entity that does not exhibit biological activity.
""" ;
  rdfs:subClassOf sio:PharmaceuticalIngredient .

sio:InclusionCriterion a owl:Class ;
  rdfs:comment """An inclusion criterion is a criterion that must be present to satisfy some objective.
""" ;
  rdfs:subClassOf sio:Criterion .

sio:IncreaseInNumberOfObjectsProduced a owl:Class ;
  rdfs:comment """An increase in the number of objects produced is the positive value of a difference in number of objects produced.
""" ;
  rdfs:subClassOf sio:DifferenceInNumberOfObjectsProduced .

sio:Increased a owl:Class ;
  rdfs:comment "A quality that has a value that is increased compared to normal or average." ;
  rdfs:subClassOf sio:Abnormal .

sio:IncreasedChemicalDestruction a owl:Class ;
  rdfs:comment """increased chemical destruction is a process in which there is an increase in the amount of chemical destroyed relative to some reference process
""" ;
  rdfs:subClassOf sio:ChemicalDestruction .

sio:IncreasedDurationOfProcessFromIncreasedRegulation a owl:Class ;
  rdfs:comment """increased duration of process from increased regulation is a process in which the duration of the target process is increased as a result of increased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessDuration .

sio:IncreasedFrequencyOfProcessFromIncreasedRegulation a owl:Class ;
  rdfs:comment """The increase of regulation leads to a increased occurence of processes of the target type.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessFrequency .

sio:IncreasedMolecularDegradationFromDecreasedRegulation a owl:Class ;
  rdfs:comment """A process that increases the frequency, rate or extent of process involved in the destruction of a molecule as a result of decreased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularDegradation .

sio:IncreasedMolecularDegradationFromIncreasedRegulation a owl:Class ;
  rdfs:comment """A process that increases the frequency, rate or extent of process involved in the destruction of a molecule as a result of increased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularDegradation .

sio:IncreasedMolecularProductionFromDecreasedRegulation a owl:Class ;
  rdfs:comment """A process that increases the frequency, rate or extent of process involved in the production of a molecule as a result of decreased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularProduction .

sio:IncreasedMolecularProductionFromIncreasedRegulation a owl:Class ;
  rdfs:comment """A process that increases the frequency, rate or extent of process involved in the production of a molecule as a result of increased regulation.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularProduction .

sio:IncreasedObjectConsumptionFromIncreasedRegulation a owl:Class ;
  rdfs:comment """increased regulation leads to an increase in the consumption of an object of specified type.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectConsumption .

sio:IncreasedObjectProductionFromIncreasedRegulation a owl:Class ;
  rdfs:comment """increased regulation leads to an increase in the number of target objects of a specified type.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectProduction .

sio:IncreasedSpatialExtentOfProcessFromIncreasedRegulation a owl:Class ;
  rdfs:comment """The increase of regulation leads to a increased spatial extent of the target process.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessSpatialExtent .

sio:IncreasingLine a owl:Class ;
  rdfs:comment """An increasing line is a line segment in which the startpoint and endpoint are ordered along one dimension and the difference of values in a second dimension is positive.
""" ;
  rdfs:subClassOf sio:TrendLine .

sio:Indecision a owl:Class ;
  rdfs:comment """indecision is the emotion of being unable to choose between two or more possible courses of action.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:IndependentVariable a owl:Class ;
  rdfs:comment """An independent variable is a variable that may take on different values independent of other elements in a system.
""" ;
  rdfs:subClassOf sio:Variable .

sio:Indifference a owl:Class ;
  rdfs:comment """indifference is an emotion characterized by lack of interest, concern, or sympathy.
""" ;
  rdfs:subClassOf sio:Emotion .

sio:IndiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:InductiveArgument a owl:Class ;
  rdfs:comment """An inductive argument is an argument that asserts that the truth of the conclusion is supported by the premises.
""" ;
  rdfs:subClassOf sio:Argument .

sio:InfiniteLine a owl:Class ;
  rdfs:comment """An infinite line is a line that extends outwards in both directions of a single dimensional and is not bounded by terminal points.
""" ;
  rdfs:subClassOf sio:Line .

sio:InformationContentEntity a owl:Class ;
  rdfs:comment """information content entity is an object that requires some background knowledge or procedure to correctly interpret.
""" ;
  rdfs:subClassOf sio:Object .

sio:InformationDecoding a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:InformationTranslation .

sio:InformationEncoding a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:InformationTranslation .

sio:InformationMaintenance a owl:Class ;
  rdfs:comment "the regulation or maintenance of information" ;
  rdfs:subClassOf sio:ProcessMaintenance .

sio:InformationProcessing a owl:Class ;
  rdfs:comment """information processing is a process that involves the generation or use of information.
""" ;
  rdfs:subClassOf sio:Procedure .

sio:InformationTranslation a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:InformationProcessing .

sio:InformationalEntityIdentifier a owl:Class ;
  rdfs:comment "An informational entity identifier is an identifier for an informational entity." ;
  rdfs:subClassOf sio:Identifier .

sio:InformationalQuality a owl:Class ;
  rdfs:comment "An informational quality is a quality that pertains to information." ;
  rdfs:subClassOf sio:Quality .

sio:Ingredient a owl:Class ;
  rdfs:comment "an ingredient is a chemical substance that forms part of a mixture." ;
  rdfs:subClassOf sio:ChemicalSubstance .

sio:Inhibitor a owl:Class ;
  rdfs:comment """A molecular inhibitor is a molecular regulator that realizes its disposition to conformationally change a target molecule and decrease its functionality.
""" ;
  rdfs:subClassOf sio:MolecularRegulator .

sio:InhibitorRole a owl:Class ;
  rdfs:comment "The role of a chemical entity that reduces the rate of reaction." ;
  rdfs:subClassOf sio:RegulatorRole .

sio:InorganicReaction a owl:Class ;
  rdfs:comment """An inorganic reaction is a chemical reaction that involves the transformation of inorganic molecules.
""" ;
  rdfs:subClassOf sio:ChemicalReaction .

sio:InsertionVariantRole a owl:Class ;
  rdfs:comment """An insertion variant role is the role of an sequence that contains a sub-sequence that is considered to be an addition relative to the frame of reference.
""" ;
  rdfs:subClassOf sio:SequenceVariantRole .

sio:Institute a owl:Class ;
  rdfs:comment """institute is a society or organization having a object or common factor, and is normally applied to those with a scientific, educational, or social objective.
""" ;
  rdfs:subClassOf sio:Organization .

sio:IntegerScale a owl:Class ;
  rdfs:comment "An integer scale of measurement is one that only specifies integer values." ;
  rdfs:subClassOf sio:NumericScale .

sio:Intensity a owl:Class ;
  rdfs:comment "intensity is a quality that represents the strength or degree of something." ;
  rdfs:subClassOf sio:Quality .

sio:Intent a owl:Class ;
  rdfs:comment "intent is a desire to realize a particular outcome." ;
  rdfs:subClassOf sio:Desire .

sio:Interacting a owl:Class ;
  rdfs:comment """interacting is a process characterized by the interaction between two or more entities.
""" ;
  rdfs:subClassOf sio:Process .

sio:Interest a owl:Class ;
  rdfs:comment "interest is the emotion of wanting to know or learn about something or someone." ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:Intersection a owl:Class ;
  rdfs:comment """An intersection is a list of only the values of an attribute for the entities in the defined set where all entities have that value.
""" ;
  rdfs:subClassOf sio:List .

sio:Intersex a owl:Class ;
  rdfs:comment """intersex is a biological sex characterised by birth with genitalia and/or secondary sexual characteristics of indeterminate sex, or which combine features of both sexes.
""" ;
  rdfs:subClassOf sio:BiologicalSex .

sio:Interval a owl:Class ;
  rdfs:comment """an interval is a set of real numbers with the property that any number that lies between two numbers in the set is also included in the set.
""" ;
  rdfs:seeAlso sio:Set ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:InterventionGroup a owl:Class ;
  rdfs:comment """An intervention group is a group of individuals that are subject to an intervention.
""" ;
  rdfs:subClassOf sio:StudyGroup .

sio:InterventionStudy a owl:Class ;
  rdfs:comment """An intervention study has the objective of improving the condition of an individual or a group of individuals, and demonstrates the magnitude of that capability by comparing it to a control group.
""" ;
  rdfs:subClassOf sio:Experiment .

sio:IntroductionSection a owl:Class ;
  rdfs:comment """An introduction section is a document section that generally provides background, motivation and goals of the work.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:Intron a owl:Class ;
  rdfs:comment """An intron is a region of a gene that is removed from the final protein open reading frame.
""" ;
  rdfs:subClassOf sio:GeneComponent .

sio:InvalidArgument a owl:Class ;
  rdfs:comment """An invalid argument is an argument where the truth of the conclusion is false because it is not a logical consequence of the premises.
""" ;
  rdfs:subClassOf sio:Argument .

sio:Investigation a owl:Class ;
  rdfs:comment """investigation is the process of carrying out a plan or procedure so as to discover facts or information about the object of study.
""" ;
  rdfs:subClassOf sio:Procedure .

sio:InvestigationalRole a owl:Class ;
  rdfs:comment """An investigational role is a role held by participants involved in an investigation.
""" ;
  rdfs:subClassOf sio:ProcessualRole .

sio:IodineAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Ion a owl:Class ;
  rdfs:comment """An ion is an atom or molecule in which the total number of electrons is not equal to the total number of protons, giving it a net positive or negative electrical charge.
""" ;
  rdfs:subClassOf sio:ChemicalEntity .

sio:IonicCompound a owl:Class ;
  rdfs:comment """An ionic compound is a mereological maximal sum of weakly connected paired positive and negative ions.
""" ;
  rdfs:subClassOf sio:BinaryCompound .

sio:IonicInteraction a owl:Class ;
  rdfs:comment """An ionic interaction is a weak submolecular interaction between a charged submolecules.
""" ;
  rdfs:subClassOf sio:WeakSubmolecularComponent .

sio:Ionsdaleite a owl:Class ;
  rdfs:comment "ionsdaleite is a hexagonal allotrope of the carbon allotrope diamond." ;
  rdfs:subClassOf sio:CarbonAllotrope .

sio:IridiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:IronAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Irritability a owl:Class ;
  rdfs:comment """irritability is the negative emotion of quick excitability to annoyance, impatience, or anger.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Isomer a owl:Class ;
  rdfs:comment """An isomer is a molecule that is compositionally identical to another molecule as a result of a different atomic connectivity.
""" ;
  rdfs:subClassOf sio:Molecule .

sio:IsomerizationReaction a owl:Class ;
  rdfs:comment """An isomerization reaction is a chemical reaction in which a molecule is converted into its isomer.
""" ;
  rdfs:subClassOf sio:ChemicalReaction .

sio:Issue a owl:Class ;
  rdfs:comment """An issue is a single instance of a periodically published journal, magazine, or newspaper.
""" ;
  rdfs:subClassOf sio:EditedPublication .

sio:Jealousy a owl:Class ;
  rdfs:comment """jealousy is an emotion and typically refers to the negative thoughts and feelings of insecurity, fear, and anxiety over an anticipated loss of something that the person values, particularly in reference to a human connection.
""" ;
  rdfs:subClassOf sio:Envy .

sio:Journal a owl:Class ;
  rdfs:comment """A journal is a a peer-reviewed periodical in which scholarship relating to a particular academic discipline is published.
""" ;
  rdfs:subClassOf sio:Periodical .

sio:Joy a owl:Class ;
  rdfs:comment "joy is an emotion of intense happiness." ;
  rdfs:subClassOf sio:Happiness .

sio:Justification a owl:Class ;
  rdfs:comment """A justification is a proposition that defends, explains or excuses some argument.
""" ;
  rdfs:subClassOf sio:Proposition .

sio:Keyword a owl:Class ;
  rdfs:comment """A keyword is a descriptor in which the association of the word with the entity facilitates information retrieval.
""" ;
  rdfs:subClassOf sio:Descriptor .

sio:KryptonAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Label a owl:Class ;
  rdfs:comment "a label is a term that is associated with some entity" ;
  rdfs:subClassOf sio:Term .

sio:Language a owl:Class ;
  rdfs:comment """Language is a language entity which is the result of encoding and decoding information through systematic creation and usage of systems of symbols, each pairing a specific sign with an intended meaning, established through social conventions
""" ;
  rdfs:subClassOf sio:LanguageEntity .

sio:LanguageEntity a owl:Class ;
  rdfs:comment """A language entity implements some language specification for the visual interpretation and is part of some document.
""" ;
  rdfs:subClassOf sio:InformationContentEntity , [
    a owl:Restriction ;
    owl:onProperty sio:is_annotation_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_annotation_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:LanguageLabel a owl:Class ;
  rdfs:comment "A language label is a label that denotes the language of a textual entity." ;
  rdfs:subClassOf sio:Label .

sio:LanthanumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:LastName a owl:Class ;
  rdfs:comment """A last name (surname) is a name added to a given name and is part of a personal name and is often the family name.
""" ;
  rdfs:subClassOf sio:Name .

sio:Latitude a owl:Class ;
  rdfs:comment """Latitude is a geographic coordinate which refers to the angle from a point on the Earth's surface to the equatorial plane
""" ;
  rdfs:subClassOf sio:GeographicPosition .

sio:LawrenciumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:LeadAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Learning a owl:Class ;
  rdfs:comment "learning is the agentive process of acquiring knowledge." ;
  rdfs:subClassOf sio:Creating .

sio:LeftHandedHelical a owl:Class ;
  rdfs:comment """left-handed helical quality is the quality in which a clockwise screwing motion moves the helix towards the observed along the line of sight along the helix's axis.
""" ;
  rdfs:subClassOf sio:Helicity .

sio:LeftClosedInterval a owl:Class ;
  rdfs:comment """a left closed interval is an interval in which there is a real number that is smaller than all its elements.
""" ;
  rdfs:subClassOf sio:Interval .

sio:LeftOpenInterval a owl:Class ;
  rdfs:comment """a left open interval is an interval in which there is no element that is smaller than all other elements.
""" ;
  rdfs:subClassOf sio:Interval .

sio:LeftValueAxis a owl:Class ;
  rdfs:comment """A left value axis is a value axis that is spatially positioned to the left of the plot area.
""" ;
  rdfs:subClassOf sio:ValueAxis .

sio:LegalDocument a owl:Class ;
  rdfs:comment """A legal document is a formally executed written document that can be formally attributed to its author, records and formally expresses a legally enforceable act, process, or contractual duty, obligation, or right, and therefore evidences that act, process, or agreement.
""" ;
  rdfs:subClassOf sio:Document .

sio:LegalName a owl:Class ;
  rdfs:comment """A legal name is a name given at birth, or which appears on their birth certificate, marriage certificate, or change of name certificate.
""" ;
  rdfs:subClassOf sio:PersonalName .

sio:Legend a owl:Class ;
  rdfs:comment """A legend is a part of a figure that associates textual descriptions with symbols pertaining to plotted entities.
""" ;
  rdfs:subClassOf sio:FigurePart .

sio:Legislation a owl:Class ;
  rdfs:comment "A legal document proposing or enacting a law or a group of laws." ;
  rdfs:subClassOf sio:LegalDocument .

sio:Length a owl:Class ;
  rdfs:comment "length is the longer dimensional extent along a 2D projection of the object." ;
  rdfs:subClassOf sio:1DExtentQuantity .

sio:LengthOfPerimeter a owl:Class ;
  rdfs:comment "A perimeter is a length of the outline that surrounds a two-dimensional shape. " ;
  rdfs:subClassOf sio:2DExtentQuantity .

sio:Letter a owl:Class ;
  rdfs:comment """A letter is a document that contains a personal communication from one part to another.
""" ;
  rdfs:subClassOf sio:Document .

sio:LifeStatus a owl:Class ;
  rdfs:comment "life status is the quality of whether something is alive or dead." ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:Ligand a owl:Class ;
  rdfs:comment """A ligand is a molecule that is part of a complex by weakly interacting with another molecule.
""" ;
  rdfs:subClassOf sio:Molecule .

sio:Likelihood a owl:Class ;
  rdfs:comment """Likelihood is the hypothetical probability that an event that has already occurred would yield a specific outcome.
""" ;
  rdfs:subClassOf sio:Quantity .

sio:Line a owl:Class ;
  rdfs:comment """A line is curve that extends in a single dimension (e.g. straight line; exhibits no curvature), and is composed of at least two fully connected points.
""" ;
  rdfs:subClassOf sio:Curve .

sio:LineBarGraph a owl:Class ;
  rdfs:comment "A line-bar graph statistical graph that contains both lines and bars." ;
  rdfs:subClassOf sio:StatisticalGraph .

sio:LineGraph a owl:Class ;
  rdfs:comment """A line graph is a statistical graph in which lines contains the evaluation of functions or individual points connected by line segments.
""" ;
  rdfs:subClassOf sio:StatisticalGraph .

sio:LineSegment a owl:Class ;
  rdfs:comment """A line segment is a line and a part of a curve that is (inclusively) bounded by two terminal points.
""" ;
  rdfs:subClassOf sio:Line .

sio:LinearPosition a owl:Class ;
  rdfs:comment """A linear position is the position of some object against a linear positioning system.
""" ;
  rdfs:subClassOf sio:Position .

sio:LinearValueAxis a owl:Class ;
  rdfs:comment """A linear value axis is a value axis that corresponds to a scaling factor of 1 of the value range.
""" ;
  rdfs:subClassOf sio:ScaledValueAxis .

sio:Lipid a owl:Class ;
  rdfs:comment "A lipid is a water-insoluable organic molecule." ;
  rdfs:subClassOf sio:OrganicMolecule .

sio:LipidResidue a owl:Class ;
  rdfs:comment """A lipid residue is a part of an organic molecule that was derived from a lipid molecule.
""" ;
  rdfs:subClassOf sio:OrganicSubmolecule .

sio:LiquidSolution a owl:Class ;
  rdfs:comment "A liquid solution is a heterogeneous substance in a liquid state." ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:LiquidSolutionComponent a owl:Class ;
  rdfs:comment "A liquid solution component is a part of a liquid solution." ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:List a owl:Class ;
  rdfs:comment "A list is any enumeration of a set of items." ;
  rdfs:subClassOf sio:Set .

sio:ListItem a owl:Class ;
  rdfs:comment "a list item is an item in a list." ;
  rdfs:subClassOf sio:SetItem .

sio:LiteratureCuration a owl:Class ;
  rdfs:comment """literature curation is the process of an agent selecting and extracting terms and phrases from a document.
""" ;
  rdfs:subClassOf sio:InformationProcessing .

sio:LithiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Loathing a owl:Class ;
  rdfs:comment "loathing is an intense dislike or disgust." ;
  rdfs:subClassOf sio:Disgust .

sio:LocalMaximumStationaryPoint a owl:Class ;
  rdfs:comment """A local maximum stationary point is a point that has a higher value in  some axis than adjacent points.
""" ;
  rdfs:subClassOf sio:StationaryPoint .

sio:LocalMinimumStationaryPoint a owl:Class ;
  rdfs:comment """A local minimum stationary point is a point that has a lower value in  some axis than adjacent points.
""" ;
  rdfs:subClassOf sio:StationaryPoint .

sio:Locomotion a owl:Class ;
  rdfs:comment "The self-propelled movement of an object." ;
  rdfs:subClassOf sio:ActiveMovement .

sio:LogLikelihood a owl:Class ;
  rdfs:comment "Log likelihood is the natural logarithm of the likelihood function" ;
  rdfs:subClassOf sio:Likelihood .

sio:LogarithmicValueAxis a owl:Class ;
  rdfs:comment """A logarithmic value axis is a scaled value axis that corresponds to a scaling factor of the logarithm of the value range.
""" ;
  rdfs:subClassOf sio:ScaledValueAxis .

sio:LogicalOperator a owl:Class ;
  rdfs:comment """A logical operator is a unary or binary relation to construct logical expressions.
""" ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:Loneliness a owl:Class ;
  rdfs:comment """Loneliness is an unpleasant emotion in which a person feels a strong sense of emptiness, yearning distress and solitude resulting from inadequate quantity or quality of social relationships.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Longitude a owl:Class ;
  rdfs:comment """Longitude is a geographic position that refers to  the angle east or west of a reference meridian between the two geographical poles to another meridian that passes through an arbitrary point.
""" ;
  rdfs:subClassOf sio:GeographicPosition .

sio:Love a owl:Class ;
  rdfs:comment "love is an emotion of a strong affection and personal attachment." ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:LowBarrierHydrogenBond a owl:Class ;
  rdfs:comment """A low barrier hydrogen bond is a shorter, stronger hydrogen bond that is formed between both heteroatoms.
""" ;
  rdfs:subClassOf sio:HydrogenBond .

sio:Lust a owl:Class ;
  rdfs:comment "lust is the strong desire for sex." ;
  rdfs:subClassOf sio:Desire .

sio:LutetiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:MrnaSpliceVariant a owl:Class ;
  rdfs:comment """An mRNA splice variant is an mRNA molecule that varies from another mRNA molecule of the same gene origin but having a different final sequence due to differences in its assembly from splice sites.
""" ;
  rdfs:subClassOf sio:MessengerRna .

sio:Magazine a owl:Class ;
  rdfs:comment """A magazine is a periodical that typically contains essays, stories, poems, etc., by many writers, and often photographs and drawings, frequently specializing in a particular subject or area, as hobbies, news, or sports.
""" ;
  rdfs:subClassOf sio:Periodical .

sio:MagnesiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:MaintenanceOfDurationOfProcess a owl:Class ;
  rdfs:comment """maintenance of duration of process is a process that regulates a target process to maintain its duration within an expected interval.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessDuration .

sio:MaintenanceOfFrequencyOfProcess a owl:Class ;
  rdfs:comment """maintenance of frequency of process is a process that regulates the number of occurences of a target process type to a specified number or interval.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessFrequency .

sio:MaintenanceOfLevelOfObjectConsumption a owl:Class ;
  rdfs:comment """regulation of a participant quantity is the regulation of a process in which the quantity of a selected participant is maintained at a steady level.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectConsumption .

sio:MaintenanceOfQuantityOfObjectProduction a owl:Class ;
  rdfs:comment """maintenance of quantity of object production is a regulation of object production in which the number of objects produced is held more or less constant.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectProduction .

sio:MaintenanceOfSpatialExtentOfProcess a owl:Class ;
  rdfs:comment """maintenance of spatial extent of process is a regulation of a process' spatial extent within some specified parameter.
""" ;
  rdfs:subClassOf sio:RegulationOfProcessSpatialExtent .

sio:MajorTickMark a owl:Class ;
  rdfs:comment """A major tick mark is a tick mark that indicates the position of a specific numeric value and is adjacent to its value label on the value axis, or is one of a pair of tick marks that delineates the boundary of a categorical value indicated by an adjacent category label on the categorical axis.
""" ;
  rdfs:subClassOf sio:TickMark .

sio:MajorVersionNumber a owl:Class ;
  rdfs:comment """A major version number is a version of a software that exhibits a significant change in functionalilty from a prior version.
""" ;
  rdfs:subClassOf sio:SoftwareVersionLabel .

sio:Male a owl:Class ;
  rdfs:comment "male is a biological sex of an individual with male sexual organs." ;
  rdfs:subClassOf sio:BiologicalSex .

sio:ManganeseAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Manual a owl:Class ;
  rdfs:comment "A manual is a document that instructs on the usage of a device." ;
  rdfs:subClassOf sio:Publication .

sio:Manuscript a owl:Class ;
  rdfs:comment "A manuscript is a document prior to publication." ;
  rdfs:subClassOf sio:Document .

sio:Map a owl:Class ;
  rdfs:comment """A map is a a visual representation of an area that depicts the relationship between elements of that space.
""" ;
  rdfs:subClassOf sio:Chart .

sio:Mass a owl:Class ;
  rdfs:comment "mass is the quality of the amount of substance." ;
  rdfs:subClassOf sio:SpatialQuantity .

sio:MassSpectrometer a owl:Class ;
  rdfs:comment """A mass spectrometer is a device that identifies ions based on their mass to charge ratio using an electromagnetic field.
""" ;
  rdfs:subClassOf sio:DataCollectionDevice .

sio:MassSpectrometryExperiment a owl:Class ;
  rdfs:comment """A mass spectrometry experiment is an experiment that involves the use of a mass spectrometer. 
""" ;
  rdfs:subClassOf sio:Experiment .

sio:Master27SThesis a owl:Class ;
  rdfs:comment "A Master's thesis is a thesis prepared as a requirement for a Master's degree." ;
  rdfs:subClassOf sio:ThesisDocument .

sio:MaterialBoundary a owl:Class ;
  rdfs:comment """A material boundary is the boundary of a material entity which exists as a lower dimensional entity at exactly the location where its parts no longer extend into space. Every material entity has a boundary, and a boundary is the boundary of exactly 1 material entity.
""" ;
  rdfs:subClassOf sio:SpatialBoundary .

sio:MaterialEntity a owl:Class ;
  rdfs:comment """A material entity is a physical entity that is spatially extended, exists as a whole at any point in time and has mass.
""" ;
  rdfs:subClassOf sio:Object .

sio:MaterialsAndMethodsSection a owl:Class ;
  rdfs:comment """The materials and methods section is a document section containing a description of the materials and methods used in the study.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:MaterialsSection a owl:Class ;
  rdfs:comment """The materials section is a document section containing a description of the materials used in the study.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:MaternallyTransmitted a owl:Class ;
  rdfs:comment """maternally transmitted is the quality of a biological organism in which the (genetic) material is transmitted from the maternal line.
""" ;
  rdfs:subClassOf sio:ParentalTransmission .

sio:MathematicalEntity a owl:Class ;
  rdfs:comment """A mathematical entity is an information content entity that are components of a mathematical system or can be defined in mathematical terms.
""" ;
  rdfs:subClassOf sio:InformationContentEntity , [
    a owl:Restriction ;
    owl:onProperty sio:has_unit ;
    owl:allValuesFrom sio:UnitOfMeasurement
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_unit ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Matrix a owl:Class ;
  rdfs:comment """a matrix is a rank 2 tensor. It is represented as a rectangular array or table of numbers, symbols, or expressions arranged in rows and columns.
""" ;
  rdfs:subClassOf sio:RankNonzeroTensor .

sio:MatrixChart a owl:Class ;
  rdfs:comment "A matrix chart summarizes a multidimensional data set in a grid." ;
  rdfs:subClassOf sio:Chart .

sio:MatureMrna a owl:Class ;
  rdfs:comment """A mature RNA is a ribonucleic acid that contains an untranslated region (UTR) and protein coding sequence and lacks introns.
""" ;
  rdfs:subClassOf sio:MessengerRna .

sio:MaximalValue a owl:Class ;
  rdfs:comment """A maximal value is largest value of an attribute for the entities in the defined set.
""" ;
  rdfs:subClassOf sio:Quantity .

sio:Mean a owl:Class ;
  rdfs:comment """A mean is the central tendency of a collection of numbers taken as the sum of the numbers divided by the size of the collection.
""" ;
  rdfs:subClassOf sio:CentralityMeasure .

sio:MeasurementScale a owl:Class ;
  rdfs:comment """A measurement scale is a functional specification that specifies an allowed range of categories or values.
""" ;
  rdfs:subClassOf sio:FunctionalSpecification .

sio:MeasurementValue a owl:Class ;
  rdfs:comment """A measurement value is a quantitative description that reflects the magnitude of some attribute.
""" ;
  rdfs:subClassOf sio:Number , [
    a owl:Restriction ;
    owl:onProperty sio:is_measurement_value_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_measurement_value_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Measuring a owl:Class ;
  rdfs:comment """measuring is the process of determining the size, amount, or degree of (something) by using an instrument or device marked in standard units
""" ;
  rdfs:subClassOf sio:Interacting .

sio:Media a owl:Class ;
  rdfs:comment """media are audo/visual/audiovisual modes of communicating information for mass consumption.
""" ;
  rdfs:subClassOf sio:InformationContentEntity .

sio:Median a owl:Class ;
  rdfs:comment """A median is the numerical value separating the higher half of a sample, a population, or a probability distribution, from the lower half. 
""" ;
  rdfs:subClassOf sio:CentralityMeasure .

sio:MedicalData a owl:Class ;
  rdfs:comment "medical data is data of interest to medicine." ;
  rdfs:subClassOf sio:BiologicalData .

sio:MedicalDiagnosis a owl:Class ;
  rdfs:comment """A medical diagnosis (often simply termed diagnosis) refers to the process of attempting to determine or identify a possible disease or disorder.
""" ;
  rdfs:subClassOf sio:MedicalProcedure .

sio:MedicalHealthRecord a owl:Class ;
  rdfs:comment "A medical health record is a record of a single patient's medical history." ;
  rdfs:subClassOf sio:Record .

sio:MedicalHistory a owl:Class ;
  rdfs:comment "A medical history is a record of the events of a recipient of medical care." ;
  rdfs:subClassOf sio:History .

sio:MedicalIntervention a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:MedicalProcedure .

sio:MedicalPractitioner a owl:Class ;
  rdfs:comment "A medical practioner is an individual that provides medical care." ;
  rdfs:subClassOf sio:Person .

sio:MedicalProcedure a owl:Class ;
  rdfs:comment """A medical procedure is a procedure to identify, examine, alleviate or eliminate an undesirable biological disease or disorder.
""" ;
  rdfs:subClassOf sio:Procedure .

sio:MedicalReport a owl:Class ;
  rdfs:comment """A medical report is a report prepared by a health care practioner about test outcomes or health status of an individual.
""" ;
  rdfs:subClassOf sio:Report .

sio:MedicalRole a owl:Class ;
  rdfs:comment """A medical role is the role of an individual that is a participant in the delivery of medical care.
""" ;
  rdfs:subClassOf sio:OccupationalRole .

sio:MedicalScreening a owl:Class ;
  rdfs:comment """A medical screening is a medical test or series used to detect or predict the presence of disease in individuals at risk for disease within a defined group, such as a population, family, or workforce
""" ;
  rdfs:subClassOf sio:MedicalProcedure .

sio:MeitneriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:MemberCount a owl:Class ;
  rdfs:comment "A count of the instances of a class or members in a collection." ;
  rdfs:subClassOf sio:Count .

sio:MembraneTransport a owl:Class ;
  rdfs:comment "membrane transport is the movement of molecules across a membrane." ;
  rdfs:subClassOf sio:ChemicalTransport .

sio:MendeleviumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:MercuryAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:MereologicalChart a owl:Class ;
  rdfs:comment """A mereological chart is a chart that illustrates the parts in the context of the whole.
""" ;
  rdfs:subClassOf sio:Chart .

sio:MereologicalQuality a owl:Class ;
  rdfs:comment """a mereological quality is a quality of an entity vis-a-vis containment or parthood
""" ;
  rdfs:subClassOf sio:ObjectQuality .

sio:Messenger a owl:Class ;
  rdfs:comment """A mesenger is a molecule involved in either signal detection or signal propagation from receptors on the cell surface to target molecules inside the cell, in the cytoplasm or nucleus.
""" ;
  rdfs:subClassOf sio:SignalTransducer .

sio:MessengerRna a owl:Class ;
  rdfs:comment """A messenger RNA is a ribonucleic acid that contains an untranslated region (UTR) and protein coding sequence and lacks introns.
""" ;
  rdfs:subClassOf sio:RnaTranscript .

sio:MetabolicPathway a owl:Class ;
  rdfs:comment """A metabolic pathway is a series of biochemical reactions that begins with one or more substrates and ends with one or more products.
""" ;
  rdfs:subClassOf sio:BiochemicalPathway .

sio:Metabolism a owl:Class ;
  rdfs:comment """Metabolism is the set of chemical processes that occur within a living organism in order to maintain life.
""" ;
  rdfs:subClassOf sio:ChemicalInteraction .

sio:Metadata a owl:Class ;
  rdfs:comment "metadata is data that provides information about data." ;
  rdfs:subClassOf sio:DataItem .

sio:MethodsSection a owl:Class ;
  rdfs:comment """The methods section is a document section containing a description of the methods used in the study.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:MicroRnAmiRna a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRna .

sio:MicroarrayDevice a owl:Class ;
  rdfs:comment """A microarray device is a device that identifies the binding of a target substance to a physically immobile substrate placed in an array or lattice.
""" ;
  rdfs:subClassOf sio:DataCollectionDevice .

sio:MicroarrayExperiment a owl:Class ;
  rdfs:comment """A microarray experiment is an experiment that involves a microarray device to measure the expression of one or more genes.
""" ;
  rdfs:subClassOf sio:Experiment .

sio:MicroarrayProbeSetIdentifier a owl:Class ;
  rdfs:comment """A microarray probe set identifier is an identifier for a set of probe pairs selected to represent expressed sequences on an array. 
""" ;
  rdfs:subClassOf sio:MolecularIdentifier .

sio:MiddleInitial a owl:Class ;
  rdfs:comment "a middle initial is an abbreviated middle name." ;
  rdfs:subClassOf sio:MiddleName .

sio:MiddleName a owl:Class ;
  rdfs:comment """a middle name is a name assigned to an individual that is not the first or last name.
""" ;
  rdfs:subClassOf sio:Name .

sio:Mild a owl:Class ;
  rdfs:comment """mild is a qualitative intensity value that is more intense than weak, but less intense than moderate.
""" ;
  rdfs:subClassOf sio:Intensity .

sio:Millennium a owl:Class ;
  rdfs:comment "A millenium is a period of 1000 years" ;
  rdfs:subClassOf sio:TimeInterval .

sio:MinimalValue a owl:Class ;
  rdfs:comment """A minimal value is smallest value of an attribute for the entities in the defined set.
""" ;
  rdfs:subClassOf sio:Quantity .

sio:MinorTickMark a owl:Class ;
  rdfs:comment """A minor tick mark is a tick mark that indicates the position of a specific numeric value but has no adjacent value label, or is one of a pair of tick marks that delineates the boundary of a categorical value but has no adjacent category label on the categorical axis.
""" ;
  rdfs:subClassOf sio:TickMark .

sio:MinorVersionNumber a owl:Class ;
  rdfs:comment """A minor version number is a version of a software that exhibits minor features or significant fix from a prior version.
""" ;
  rdfs:subClassOf sio:SoftwareVersionLabel .

sio:Minute a owl:Class ;
  rdfs:comment "A minute is a period of 60 seconds." ;
  rdfs:subClassOf sio:TimeInterval .

sio:Misery a owl:Class ;
  rdfs:comment "misery is a feeling of great unhappiness, suffering and/or pain." ;
  rdfs:subClassOf sio:Sadness .

sio:Mode a owl:Class ;
  rdfs:comment "A mode is the value that appears most often in a set of data." ;
  rdfs:subClassOf sio:CentralityMeasure .

sio:Model a owl:Class ;
  rdfs:comment "A model is a representation of some thing." ;
  rdfs:subClassOf sio:Representation .

sio:Moderate a owl:Class ;
  rdfs:comment """moderate is a qualitative intensity value that is more intense than mild, but less intense than strong.
""" ;
  rdfs:subClassOf sio:Intensity .

sio:ModeratelyQuantifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QuantityModifier .

sio:Modifying a owl:Class ;
  rdfs:comment """modifying is the process by which an entity gains or loses parts, qualities, roles, dispositions, functions, etc, but maintains their identity through these changes.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:MolecularComplex a owl:Class ;
  rdfs:comment """A molecular complex is a chemical complex composed of at least one weakly interacting molecule.
""" ;
  rdfs:subClassOf sio:ChemicalComplex .

sio:MolecularComplexDissociation a owl:Class ;
  rdfs:comment """molecular complex disassociation is the process of dissambly of a molecular complex into its constitutent parts.
""" ;
  rdfs:subClassOf sio:ChemicalDestruction .

sio:MolecularComplexFormation a owl:Class ;
  rdfs:comment """molecular complex formation is the process of forming a molecular complex from its constituent parts.
""" ;
  rdfs:subClassOf sio:ChemicalSynthesis .

sio:MolecularEntityRole a owl:Class ;
  rdfs:comment "A molecular entity role is a chemical entity role held by a molecule." ;
  rdfs:subClassOf sio:ChemicalEntityRole .

sio:MolecularIdentifier a owl:Class ;
  rdfs:comment "A molecular identifier is an identifier for a molecular entity." ;
  rdfs:subClassOf sio:ChemicalIdentifier .

sio:MolecularModification a owl:Class ;
  rdfs:comment """Molecular modification is chemical alteration of a known and previously characterized lead compound for the purpose of enhancing its usefulness as a drug. This could mean enhancing its specificity for a particular body target site, increasing its potency, improving its rate and extent of absorption, modifying to advantage its time course in the body, reducing its toxicity, changing its physical or chemical properties (like solubility) to provide desired features.
""" ;
  rdfs:subClassOf sio:ChemicalReaction .

sio:MolecularOrbital a owl:Class ;
  rdfs:comment """A molecular orbital (or MO) is a mathematical function describing the wave-like behavior of an electron in a molecule.
""" ;
  rdfs:subClassOf sio:ChemicalQuality .

sio:MolecularPocket a owl:Class ;
  rdfs:comment """A molecular pocket is a site on a molecule that appears as a depression into the structure.
""" ;
  rdfs:subClassOf sio:MolecularSite .

sio:MolecularRegulator a owl:Class ;
  rdfs:comment """A molecular regulator is a molecule that regulates the function of another chemical entity.
""" ;
  rdfs:subClassOf sio:Molecule .

sio:MolecularSite a owl:Class ;
  rdfs:comment """A moleclar site is a spatial region bounded (in part or in whole) by a molecule and may be occupied by other material entities (e.g. drugs).
""" ;
  rdfs:subClassOf sio:Site .

sio:MolecularStructure a owl:Class ;
  rdfs:comment """molecular structure is the spatial arrangement of atoms in a molecule and the chemical bonds that hold the atoms together.
""" ;
  rdfs:subClassOf sio:ChemicalStructure .

sio:MolecularStructureDescriptor a owl:Class ;
  rdfs:comment """molecular structure descriptor is data that describes some aspect of the molecular structure (composition) and is about some chemical entity.
""" ;
  rdfs:subClassOf sio:ChemicalQuality .

sio:MolecularStructureFile a owl:Class ;
  rdfs:comment """A molecular structure file is a file that contains a description of molecular structure.
""" ;
  rdfs:subClassOf sio:File .

sio:MolecularTracerRole a owl:Class ;
  rdfs:comment """A molecular tracer role is a reactant role of a molecular entity that serves as a marker for the presence, abundance, or location of a molecular target that it associates with.
""" ;
  rdfs:subClassOf sio:ReactantRole .

sio:Molecule a owl:Class ;
  rdfs:comment """A molecule is a single chemical entity composed of fully covalently bonded atoms.
""" ;
  rdfs:subClassOf sio:ChemicalEntity .

sio:MolybdemumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Monomer a owl:Class ;
  rdfs:comment """A monomer is a submolecule that is proper part of some polymer, and is a building block for such polymer.
""" ;
  rdfs:subClassOf sio:Submolecule .

sio:Monosaccharide a owl:Class ;
  rdfs:comment """A monosaccharide is an organic molecule that consists of a single polyhydroxy aldehyde or ketone group.
""" ;
  rdfs:subClassOf sio:OrganicMolecule .

sio:Month a owl:Class ;
  rdfs:comment "A month is a period of time that divides the year." ;
  rdfs:subClassOf sio:TimeInterval .

sio:Morpheme a owl:Class ;
  rdfs:comment "A morpheme is the smallest semantically meaningful unit in a language." ;
  rdfs:subClassOf sio:LanguageEntity .

sio:MostOfTheTime a owl:Class ;
  rdfs:comment "most refers to in the majority of occasions" ;
  rdfs:subClassOf sio:TemporalQualifier .

sio:MostlyQuantifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QuantityModifier .

sio:Mouse a owl:Class ;
  rdfs:comment """A mouse is a small mammal belonging to the order of rodents, characteristically having a pointed snout, small rounded ears, and a long naked or almost hairless tail. 
""" ;
  rdfs:subClassOf sio:MulticellularOrganism .

sio:Movement a owl:Class ;
  rdfs:comment "movement is the process in which an object is spatially displaced." ;
  rdfs:subClassOf sio:Process .

sio:MovementEquation a owl:Class ;
  rdfs:comment "A movement equation describes the displacement of an object in space over time." ;
  rdfs:subClassOf sio:Equation .

sio:Movie a owl:Class ;
  rdfs:comment """A movie is a series of images that are displayed in rapid succession  to give the impression of movement.
""" ;
  rdfs:subClassOf sio:Media .

sio:MulticellularOrganism a owl:Class ;
  rdfs:comment "A multi-cellular organism is an organism that consists of more than one cell." ;
  rdfs:subClassOf sio:CellularOrganism .

sio:MultipleSequenceAlignment a owl:Class ;
  rdfs:comment """A multiple sequence alignment is a sequence alignment involving more than two sequences.
""" ;
  rdfs:subClassOf sio:SequenceAlignment .

sio:MutualDisposition a owl:Class ;
  rdfs:comment """A mutual disposition is a disposition that simulataneously invokes another disposition when realized.
""" ;
  rdfs:subClassOf sio:Disposition .

sio:Name a owl:Class ;
  rdfs:comment "A name is a label used to identify an entity." ;
  rdfs:subClassOf sio:Label .

sio:Namespace a owl:Class ;
  rdfs:comment """A namespace is an informational entity that defines a logical container for a set of symbols or identifiers.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:NamespaceLabel a owl:Class ;
  rdfs:comment "A namespace label is a short name for a namespace." ;
  rdfs:subClassOf sio:Label .

sio:Negationnot a owl:Class ;
  rdfs:comment "NOT is a logical operator in that has the value true if its operand is false." ;
  rdfs:subClassOf sio:LogicalOperator .

sio:Negative a owl:Class ;
  rdfs:comment """negative is an assertional qualifier that expresses the falsity or lack of truth of a basic assertion.
""" ;
  rdfs:subClassOf sio:AssertionalQualifier .

sio:NegativeCharge a owl:Class ;
  rdfs:comment "A negative charge is a charge where the value is negative." ;
  rdfs:subClassOf sio:CompleteCharge .

sio:NegativeEmotion a owl:Class ;
  rdfs:comment "negative emotion is an emotion that does not feel good." ;
  rdfs:subClassOf sio:Emotion .

sio:NegativeNucleicAcidStrand a owl:Class ;
  rdfs:comment """The negative nucleic acid strand is the strand that is that is complimentary to the forward strand and appears from 3' to 5'.
""" ;
  rdfs:subClassOf sio:NucleicAcidStrand .

sio:NeitherGoodNorPoorQuality a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QualityDescriptor .

sio:NeitherSatisfiedOrDissatisfiedQualifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:SatisfactionQualifier .

sio:NeodymiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:NeonAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:NeptuniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:NetworkDiagram a owl:Class ;
  rdfs:comment "A network diagram consists of a set of vertices connected by edges." ;
  rdfs:subClassOf sio:Chart .

sio:Never a owl:Class ;
  rdfs:comment "never refers to in none of the occasions." ;
  rdfs:subClassOf sio:TemporalQualifier .

sio:Newspaper a owl:Class ;
  rdfs:comment """A newspaper is a periodical publication containing news regarding current events, informative articles, diverse features, editorials, and advertising.
""" ;
  rdfs:subClassOf sio:Periodical .

sio:NickelAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:NiobiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:NitrogenAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:NmrDevice a owl:Class ;
  rdfs:comment """A nuclear magnetic resonance (NMR) device is a device that applies a magnetic field to perturb nuclei with an odd number of protons and/or of neutrons in order to hav them absort and re-emit electromagnetic radiation. 
""" ;
  rdfs:subClassOf sio:DataCollectionDevice .

sio:NobeliumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Node a owl:Class ;
  rdfs:comment "a node or vertex is a point in a graph." ;
  rdfs:subClassOf sio:Point .

sio:NomimalScale a owl:Class ;
  rdfs:comment "A nominal scale of measurement only specifies a limited set of categories." ;
  rdfs:subClassOf sio:MeasurementScale .

sio:NonCellularOrganism a owl:Class ;
  rdfs:comment "A non-cellular organism is an organism that does not contain a cell." ;
  rdfs:subClassOf sio:Organism .

sio:NonPolar a owl:Class ;
  rdfs:comment "non-polar is the quality of not having a dipole." ;
  rdfs:subClassOf sio:PolarQuality .

sio:NonPolarAdditionReaction a owl:Class ;
  rdfs:comment """A non-polar addition reaction is an addition reaction involving non-polar residues.
""" ;
  rdfs:subClassOf sio:AdditionReaction .

sio:NonProteinCodingRnAncRna a owl:Class ;
  rdfs:comment """A non-protein coding RNA (ncRNA) is a RNA molecular that cannot be used as a template for generating a protein product.
""" ;
  rdfs:subClassOf sio:RnaTranscript .

sio:NonProteinCodingRnAncRnaGene a owl:Class ;
  rdfs:comment """A non-protein coding RNA (ncRNA) gene is a gene that encodes for a RNA transcript that is not further translated into a protein product.
""" ;
  rdfs:subClassOf sio:Gene .

sio:NonToxic a owl:Class ;
  rdfs:comment "non toxic is the quality of a substance having no damaging effect to a system." ;
  rdfs:subClassOf sio:Toxicity .

sio:NoneQuantifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QuantityModifier .

sio:NonpolarSolvent a owl:Class ;
  rdfs:comment "A non-polar solvent is a solvent that exhibits a non-polar quality." ;
  rdfs:subClassOf sio:Solvent .

sio:Normal a owl:Class ;
  rdfs:comment "A quality that has a value that is normal or average." ;
  rdfs:subClassOf sio:Normality .

sio:Normality a owl:Class ;
  rdfs:comment "normality is the quality in which the value may differ from normal or average" ;
  rdfs:subClassOf sio:Quality .

sio:NotStarted a owl:Class ;
  rdfs:comment """not started is the status of a process that is predicted to exist but has not yet begun.
""" ;
  rdfs:subClassOf sio:ProcessStatus .

sio:Notation a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Specification .

sio:Note a owl:Class ;
  rdfs:comment "A note is a brief document." ;
  rdfs:subClassOf sio:Document .

sio:Novel a owl:Class ;
  rdfs:comment """A novel is a fictitious prose narrative of book length, typically representing character and action with some degree of realism.
""" ;
  rdfs:subClassOf sio:Publication .

sio:NucleicAcid a owl:Class ;
  rdfs:comment """A nucleic acid is an organic polymer composed of a sequence of nucleotide residues.
""" ;
  rdfs:subClassOf sio:OrganicPolymer .

sio:NucleicAcidPart a owl:Class ;
  rdfs:comment "A nucleic acid part is a component of a nucleic acid." ;
  rdfs:subClassOf sio:OrganicSubmolecule .

sio:NucleicAcidSequence a owl:Class ;
  rdfs:comment """A nucleic acid sequence is a symbolic representation of the sequence of nucleic acid residues in a nucleic acid.
""" ;
  rdfs:subClassOf sio:BiopolymerSequence .

sio:NucleicAcidStrand a owl:Class ;
  rdfs:comment """A nucleic acid strand is a single-stranded nucleic acid that is part of a double stranded nucleic acid complex.
""" ;
  rdfs:subClassOf sio:NucleicAcid .

sio:NucleophilicAdditionReaction a owl:Class ;
  rdfs:comment """A nucleophilic addition reaction is an addition reaction where a pi bond is removed by the creation of two new covalent bonds by the addition from a nucleophile.
""" ;
  rdfs:subClassOf sio:PolarAdditionReaction .

sio:NucleotideResidue a owl:Class ;
  rdfs:comment "A nucleotide residue is a part of a molecule that derives from a nucleotide." ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Nullizygous a owl:Class ;
  rdfs:comment """nullizygous is the quality of a biological organism in which there are no allelles at a given locus.
""" ;
  rdfs:subClassOf sio:Zygosity .

sio:Number a owl:Class ;
  rdfs:comment "A number is a tensor of rank 0." ;
  rdfs:subClassOf sio:Scalar .

sio:NumberOfObjectsConsumed a owl:Class ;
  rdfs:comment """number of objects consumed is a count of objects that were consumed in some process.
""" ;
  rdfs:subClassOf sio:Count .

sio:NumberOfObjectsProduced a owl:Class ;
  rdfs:comment """number of objects produced is a count of objects that were produced in some process.
""" ;
  rdfs:subClassOf sio:Count .

sio:NumericLabel a owl:Class ;
  rdfs:comment "A numeric label is a number used as a label." ;
  rdfs:subClassOf sio:Label .

sio:NumericScale a owl:Class ;
  rdfs:comment "A numeric scale of measurement is one that only specifies numeric values." ;
  rdfs:subClassOf sio:MeasurementScale .

sio:Nurse a owl:Class ;
  rdfs:comment """A nurse is an individual that is involved in the protection, promotion, and optimization of health and abilities, prevention of illness and injury, alleviation of suffering through the diagnosis and treatment of human response, and advocacy in the care of individuals, families, communities, and populations.
""" ;
  rdfs:subClassOf sio:MedicalPractitioner .

sio:NurseRole a owl:Class ;
  rdfs:comment """A nurse role is the role of an individual that is involved in the protection, promotion, and optimization of health and abilities, prevention of illness and injury, alleviation of suffering through the diagnosis and treatment of human response, and advocacy in the care of individuals, families, communities, and populations.
""" ;
  rdfs:subClassOf sio:MedicalRole .

sio:OboOntology a owl:Class ;
  rdfs:comment """An OBO ontology is an ontology document as specified by the Open Biological Ontology community.
""" ;
  rdfs:subClassOf sio:OntologyDocument .

sio:OwlOntology a owl:Class ;
  rdfs:comment "An OWL ontology is an ontology as specified by the W3C OWL specification." ;
  rdfs:subClassOf sio:OntologyDocument .

sio:Object a owl:Class ;
  rdfs:comment """An object is an entity that is wholly identifiable at any instant of time during which it exists.
""" ;
  rdfs:subClassOf sio:Entity , [
    a owl:Restriction ;
    owl:onProperty sio:derives_into ;
    owl:allValuesFrom sio:Object
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:derives_into ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:ObjectModel a owl:Class ;
  rdfs:comment "An object model is a representation of an object." ;
  rdfs:subClassOf sio:Model .

sio:ObjectQuality a owl:Class ;
  rdfs:comment "An object quality is quality of an object." ;
  rdfs:subClassOf sio:Quality .

sio:ObjectRelationalQuality a owl:Class ;
  rdfs:comment "object relational quality refers to a quality in relation to one or more objects" ;
  rdfs:subClassOf sio:ObjectQuality .

sio:Objective a owl:Class ;
  rdfs:comment "An objective is a proposition that indicates a planned or anticipated outcome." ;
  rdfs:subClassOf sio:Proposition .

sio:ObservationalStudy a owl:Class ;
  rdfs:comment """observational study draws inferences about the possible effect of a treatment on subjects, where the assignment of subjects into a treated group versus a control group is outside the control of the investigator
""" ;
  rdfs:subClassOf sio:Experiment .

sio:Observing a owl:Class ;
  rdfs:comment """observing is a process of passive interaction in which one entity makes note of attributes of one or more entities.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:OccupationalRole a owl:Class ;
  rdfs:comment """An occupational role is a social role that pertains to an organizational structure.
""" ;
  rdfs:subClassOf sio:SocialRole .

sio:Oligopeptide a owl:Class ;
  rdfs:comment """an oligopeptide is an organic polymer composed of fewer than 10 or 15 amino acids.
""" ;
  rdfs:subClassOf sio:AminoAcidPolymer .

sio:Ongoing a owl:Class ;
  rdfs:comment "ongoing is the status of a process that is not yet complete." ;
  rdfs:subClassOf sio:ProcessStatus .

sio:Ontology a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:FormalSpecification .

sio:OntologyDocument a owl:Class ;
  rdfs:comment "An ontology document is a document that contains an ontology." ;
  rdfs:subClassOf sio:Document .

sio:OpenInterval a owl:Class ;
  rdfs:comment "an open interval is an interval that does not include its endpoints." ;
  rdfs:seeAlso sio:RightOpenInterval ;
  rdfs:subClassOf sio:LeftOpenInterval .

sio:OpenReadingFrame a owl:Class ;
  rdfs:comment """An open reading frame (ORF) is a part of a gene that encodes a protein but does not contain a stop codon.
""" ;
  rdfs:subClassOf sio:GeneComponent .

sio:Operon a owl:Class ;
  rdfs:comment """An operon is a collection of contiguous genes transcribed as a single (polycistronic) mRNA.
""" ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Opinion a owl:Class ;
  rdfs:comment """An opinion is a belief that is the result of emotion or interpretation of facts. 
""" ;
  rdfs:subClassOf sio:Belief .

sio:OpticalIsomer a owl:Class ;
  rdfs:comment """An optical isomer is a stereoisomer that rotates the plane of polarization of a beam of plane polarized light.
""" ;
  rdfs:subClassOf sio:Stereoisomer .

sio:OrderedList a owl:Class ;
  rdfs:comment "an ordered list is a list in which items are sequentially ordered." ;
  rdfs:subClassOf sio:List .

sio:OrderedListItem a owl:Class ;
  rdfs:comment "an ordered list item is an item in an ordered list." ;
  rdfs:subClassOf sio:ListItem .

sio:OrdinalPosition a owl:Class ;
  rdfs:comment """A ordinal position is a number that designates the position of an entity from the first entity in an ordered sequence of entities.
""" ;
  rdfs:subClassOf sio:LinearPosition .

sio:OrdinaryDifferentialEquation a owl:Class ;
  rdfs:comment """An ordinary differential equation (ODE) is a differential equation in which the unknown function (also known as the dependent variable) is a function of a single independent variable.
""" ;
  rdfs:subClassOf sio:DifferentialEquation .

sio:Organ a owl:Class ;
  rdfs:comment """An organ is a collection of tissues joined in structural unit to serve a common function.
""" ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:OrganicMolecule a owl:Class ;
  rdfs:comment """An organic molecule is a molecule composed of organic atoms (at least carbon, hydrogen, and optionally oxygen, phosphorus, nitrogen, sulfur)
""" ;
  rdfs:subClassOf sio:Molecule .

sio:OrganicPolymer a owl:Class ;
  rdfs:comment """An organic polymer is an organic molecule composed of connected set of monomeric units.
""" ;
  rdfs:subClassOf sio:OrganicMolecule .

sio:OrganicReaction a owl:Class ;
  rdfs:comment """An organic reaction is a chemical reaction involving at least one organic molecule.
""" ;
  rdfs:subClassOf sio:ChemicalReaction .

sio:OrganicSubmolecule a owl:Class ;
  rdfs:comment "An organic submolecule is connected region of a molecule." ;
  rdfs:subClassOf sio:Submolecule .

sio:Organism a owl:Class ;
  rdfs:comment """A biological organisn is a biological entity that consists of one or more cells and is capable of genomic replication (independently or not).
""" ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:Organization a owl:Class ;
  rdfs:comment """An organization is a collective with a complex articulation of tasks, roles and responsibilities.
""" ;
  rdfs:subClassOf sio:Collective .

sio:Orientation a owl:Class ;
  rdfs:comment """orientation is an angle between the bearer and an axis, or the angle between the bearer and another object.
""" ;
  rdfs:subClassOf sio:Position .

sio:OsmiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Osmosis a owl:Class ;
  rdfs:comment """osmosis is the movement of water molecules through a selectively-permeable membrane down a water potential gradient.
""" ;
  rdfs:subClassOf sio:Diffusion .

sio:Ovopub a owl:Class ;
  rdfs:comment """An ovopub is an information content entity that contains and links to one or more resources and/or statements, including those describing its provenance, and is itself a dereferenceable resource.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:OxygenAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:PdbChainIdentifier a owl:Class ;
  rdfs:comment """A PDB chain identifier is a alphabetical label to identify a molecule in a structure provided by the Protein DataBank .
""" ;
  rdfs:subClassOf sio:MolecularIdentifier .

sio:PdbFile a owl:Class ;
  rdfs:comment """A PDB file is a molecular structure file specified by the Protein DataBank (PDB).
""" ;
  rdfs:subClassOf sio:MolecularStructureFile .

sio:PdbRecordIdentifier a owl:Class ;
  rdfs:comment "A PDB record identifier is an identifier for a PDB generated record." ;
  rdfs:subClassOf sio:RecordIdentifier .

sio:Ph a owl:Class ;
  rdfs:comment "pH is a measure of the activity of the (solvated) hydrogen ion. " ;
  rdfs:subClassOf sio:DimensionlessQuantity .

sio:PageNumber a owl:Class ;
  rdfs:comment "A page number is the count of a page in a sequence of pages." ;
  rdfs:subClassOf sio:Count .

sio:PageRange a owl:Class ;
  rdfs:comment "A page range denotes the start and end page in some document." ;
  rdfs:subClassOf sio:Interval .

sio:PageTotal a owl:Class ;
  rdfs:comment """A page total is a textual entity that is about the number of pages in some informational entity.
""" ;
  rdfs:subClassOf sio:Count .

sio:Pain a owl:Class ;
  rdfs:comment """Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
""" ;
  rdfs:subClassOf sio:Hurt .

sio:PairwiseSequenceAlignment a owl:Class ;
  rdfs:comment "A pairwise sequence alignment is the alignment of exactly 2 sequences." ;
  rdfs:subClassOf sio:SequenceAlignment .

sio:PalladiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Panic a owl:Class ;
  rdfs:comment """Panic is a sudden emotion of fear which is so strong as to dominate or prevent reason and logical thinking, replacing it with overwhelming feelings of anxiety and frantic agitation consistent with an animalistic fight-or-flight reaction.
""" ;
  rdfs:subClassOf sio:Fear .

sio:Paragraph a owl:Class ;
  rdfs:comment """A paragraph is a self-contained unit of written discourse consisting of one or more sentences.
""" ;
  rdfs:subClassOf sio:TextualEntity .

sio:Parameter a owl:Class ;
  rdfs:comment """A parameter is variable whose value changes the characteristics of a system or a function.
""" ;
  rdfs:subClassOf sio:IndependentVariable .

sio:ParameterizedDataTransformation a owl:Class ;
  rdfs:comment """A parameterized data transformation is a data transformation whose behaviour may be modified by one or more parameters.
""" ;
  rdfs:subClassOf sio:DataTransformation .

sio:ParentalTransmission a owl:Class ;
  rdfs:comment """parental transmition is the quality of a biological organism in which the (genetic) material is transmitted from a parental unit.
""" ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:PartialCharge a owl:Class ;
  rdfs:comment "The quality of having a charge that is not a full multiple of 1 unit charge." ;
  rdfs:subClassOf sio:Charged .

sio:PartialDifferentialEquation a owl:Class ;
  rdfs:comment """A partial differential equation (PDE) is a differential equation in which the unknown function is a function of multiple independent variables and the equation involves its partial derivatives.
""" ;
  rdfs:subClassOf sio:DifferentialEquation .

sio:PartialNegativeCharge a owl:Class ;
  rdfs:comment """A partial positive charge is a partial charge where the value of the charge is positive.
""" ;
  rdfs:subClassOf sio:PartialCharge .

sio:PartialPositiveCharge a owl:Class ;
  rdfs:comment """A partial negative charge is a negative charge where the value of the charge is negative.
""" ;
  rdfs:subClassOf sio:PartialCharge .

sio:Passion a owl:Class ;
  rdfs:comment "passion is the intense desire for something." ;
  rdfs:subClassOf sio:Desire .

sio:PassiveMovement a owl:Class ;
  rdfs:comment """passive movement is the process in which an object is spatially displaced without an expenditure of energy contained in molecular bonds.
""" ;
  rdfs:subClassOf sio:Movement .

sio:PassiveTransport a owl:Class ;
  rdfs:comment """passive transport is the movement of a substance across a membrane and does not require chemical energy.
""" ;
  rdfs:subClassOf sio:MembraneTransport .

sio:Patent a owl:Class ;
  rdfs:comment """A patent is an information entity granted by a patent issuing authority which confers upon the patenter the sole right to make, use and sell an invention for a set period of time.
""" ;
  rdfs:subClassOf sio:LegalDocument .

sio:PaternallyTransmitted a owl:Class ;
  rdfs:comment """paternally transmitted is the quality of a biological organism in which the (genetic) material is transmitted from the paternal line.
""" ;
  rdfs:subClassOf sio:ParentalTransmission .

sio:Pathogen a owl:Class ;
  rdfs:comment """A pathogen or infectious agent  is a microorganism that causes disease in its host.
""" ;
  rdfs:subClassOf sio:Organism .

sio:Pathway a owl:Class ;
  rdfs:comment """A pathway is an effective specification that outlines a set of actions that forms a way to achieve an objective.
""" ;
  rdfs:subClassOf sio:ActionSpecification .

sio:Patient a owl:Class ;
  rdfs:comment "A patient is an individual that is the recepient of medical care." ;
  rdfs:subClassOf sio:Person .

sio:PatientRole a owl:Class ;
  rdfs:comment """A patient role is the role of an individual that is the recepient of medical care.
""" ;
  rdfs:subClassOf sio:MedicalRole .

sio:Pattern a owl:Class ;
  rdfs:comment """A pattern is a generalized representation of some repeatable concrete or informational item.
""" ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:PeerReviewed a owl:Class ;
  rdfs:comment """peer-reviewed is the quality of a textual entity that has been examined and commented by a peer expert reviewer.
""" ;
  rdfs:subClassOf sio:Reviewed .

sio:PeerReviewedArticle a owl:Class ;
  rdfs:comment """A peer reviewed article is an article that has undergone peer-review and deemed acceptable for publication.
""" ;
  rdfs:subClassOf sio:Article .

sio:Peptide a owl:Class ;
  rdfs:comment "a peptide is an organic polymer composed of between two and fifty amino acids." ;
  rdfs:subClassOf sio:AminoAcidPolymer .

sio:Percentage a owl:Class ;
  rdfs:comment """A percentage is a number that is a ratio expressed as a fraction of 100. It is denoted using the percent sign \"%\".
""" ;
  rdfs:subClassOf sio:Ratio .

sio:Percentile a owl:Class ;
  rdfs:comment """A percentile (or a centile) is a quantile that divides the given probability distribution, or sample, into 100 equal-sized intervals.
""" ;
  rdfs:subClassOf sio:Quantile .

sio:Perception a owl:Class ;
  rdfs:comment """perception is the organization, identification, and interpretation of sensory information in order to fabricate a mental representation through the process of transduction, which sensors in the body transform signals from the environment into encoded neural signals.
""" ;
  rdfs:subClassOf sio:Observing .

sio:Periodical a owl:Class ;
  rdfs:comment "A periodical is a publication that appears on a regular schedule." ;
  rdfs:subClassOf sio:CollectionOfDocuments .

sio:Person a owl:Class ;
  rdfs:comment """A person is an object that has certain capacities or attributes constituting personhood.
""" ;
  rdfs:subClassOf sio:SpecializedObject .

sio:PersonalName a owl:Class ;
  rdfs:comment """A personal name is a name to identify an individual person and usually comprises of a first name and a last name.
""" ;
  rdfs:subClassOf sio:Name .

sio:PharmaceuticalDrug a owl:Class ;
  rdfs:comment """A pharmaceutical preparation is a chemical substance that is approved for use in the medical diagnosis, cure, treatment, or prevention of disease.
""" ;
  rdfs:subClassOf sio:Drug .

sio:PharmaceuticalIngredient a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Ingredient .

sio:PharmacodynamicPathway a owl:Class ;
  rdfs:comment """a pharmacodynamic pathay is a regulatory pathway in which a drug molecule regulates the activity of one or more components organized in a pathway.
""" ;
  rdfs:subClassOf sio:RegulatoryPathway .

sio:PharmacokineticPathway a owl:Class ;
  rdfs:comment """a pharmacokinetic pathway is a metabolic pathway which describes the metabolism of a drug molecule.
""" ;
  rdfs:subClassOf sio:MetabolicPathway .

sio:PhdThesis a owl:Class ;
  rdfs:comment "A PhD thesis is a thesis prepared as a requirement for a doctoral degree." ;
  rdfs:subClassOf sio:ThesisDocument .

sio:Phenotype a owl:Class ;
  rdfs:comment "A phenotype is an observable characteristic of an individual." ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:PhosphorusAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Photograph a owl:Class ;
  rdfs:comment "A photograph is an image created by light falling on a light-sensitive surface." ;
  rdfs:subClassOf sio:Image .

sio:Phrase a owl:Class ;
  rdfs:comment """A phrase is a group of words functioning as a single unit in the syntax of a sentence.
""" ;
  rdfs:subClassOf sio:LanguageEntity .

sio:PhraseNetDiagram a owl:Class ;
  rdfs:comment """A phrase net diagram illustrates the relationship between different words used in a text.
""" ;
  rdfs:subClassOf sio:TextualChart .

sio:PhysicalEntityIdentifier a owl:Class ;
  rdfs:comment "A physical entity identifier is an identifier for a physical entity." ;
  rdfs:subClassOf sio:Identifier .

sio:PieChart a owl:Class ;
  rdfs:comment """A pie chart is a circular chart divided into sectors each of whose length  is proportional to the quantity it represents.
""" ;
  rdfs:subClassOf sio:MereologicalChart .

sio:Pity a owl:Class ;
  rdfs:comment "Pity is the emotion of sadness or sorrow for another." ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Placebo a owl:Class ;
  rdfs:comment """A placebo is a medically ineffectual treatment for a medical condition intended to deceive the recipient.
""" ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:Plan a owl:Class ;
  rdfs:comment """A plan is a set of intended actions, through which one expects to achieve a goal.
""" ;
  rdfs:subClassOf sio:ActionSpecification .

sio:Planned a owl:Class ;
  rdfs:comment """planned is a process status for a process that has not yet started, but is referred to in a plan.
""" ;
  rdfs:subClassOf sio:NotStarted .

sio:Planning a owl:Class ;
  rdfs:comment """planning is the agentive process of developing a plan that specifies a set of actions in order to meet a set of goals or objectives.
""" ;
  rdfs:subClassOf sio:Creating .

sio:PlateauLine a owl:Class ;
  rdfs:comment """An plateau line is a line segment in which the startpoint and endpoint are ordered along one dimension and the difference of values in a second dimension is zero.
""" ;
  rdfs:subClassOf sio:TrendLine .

sio:PlatinumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Pleasure a owl:Class ;
  rdfs:comment "pleasure is an emotion of happy satisfaction and enjoyment." ;
  rdfs:subClassOf sio:Happiness .

sio:Ploidy a owl:Class ;
  rdfs:comment """ploidy is the cellular quality relating to the amount of DNA contained in a cell.
""" ;
  rdfs:subClassOf sio:CellularQuality .

sio:Plot a owl:Class ;
  rdfs:comment """A plot is a part of a figure that corresponds to the spatial region between the set of axes.
""" ;
  rdfs:subClassOf sio:FigurePart .

sio:PlutoniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Point a owl:Class ;
  rdfs:comment """A point is a geometric entity that is located in a zero-dimensional spatial region and whose position is defined by its coordinates in some coordinate system.
""" ;
  rdfs:subClassOf sio:GeometricEntity .

sio:Poison a owl:Class ;
  rdfs:comment """A poison is a drug that is harzardous or toxic to an organism when ingested at a certain quantity.
""" ;
  rdfs:subClassOf sio:Drug .

sio:PoisonRole a owl:Class ;
  rdfs:comment """A poison role is the role of a substance that causes some negative disturbance in an organism.
""" ;
  rdfs:subClassOf sio:ToxicRole .

sio:Polar a owl:Class ;
  rdfs:comment "polar is the quality of having a dipole." ;
  rdfs:subClassOf sio:PolarQuality .

sio:PolarAdditionReaction a owl:Class ;
  rdfs:comment "A polar addition reaction is an addition reaction involving polar residues." ;
  rdfs:subClassOf sio:AdditionReaction .

sio:PolarCoordinate a owl:Class ;
  rdfs:comment """A polar coordinate is a position characterized by a distance from a fixed point and an angle from a fixed direction.
""" ;
  rdfs:subClassOf sio:Coordinate .

sio:PolarCoordinateSystem a owl:Class ;
  rdfs:comment """A polar coordinate system is a two-dimensional coordinate system in which each point on a plane is determined by a distance from a fixed point and an angle from a fixed direction.
""" ;
  rdfs:subClassOf sio:CoordinateSystem .

sio:PolarQuality a owl:Class ;
  rdfs:comment "The quality of being polar or not polar." ;
  rdfs:subClassOf sio:ChemicalQuality .

sio:PolarSolvent a owl:Class ;
  rdfs:comment "A polar solvent is a solvent that exhibits a polar quality." ;
  rdfs:subClassOf sio:Solvent .

sio:PoloniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Polygon a owl:Class ;
  rdfs:comment """A polygon is a planar entity that is bounded by a closed path or circuit, composed of a finite connected sequence3 of straight line segments.
""" ;
  rdfs:subClassOf sio:GeometricEntity .

sio:PolygonEdge a owl:Class ;
  rdfs:comment "A polygon edge is a line segment joining two polygon vertices." ;
  rdfs:subClassOf sio:LineSegment .

sio:PolygonVertex a owl:Class ;
  rdfs:comment """A polygon vertex is a terminal point at which two polygon edges meet and are part of a polygon.
""" ;
  rdfs:subClassOf sio:Node .

sio:PolygonalFace a owl:Class ;
  rdfs:comment """A polygonal face is a polygon bounded by a circuit of polygon edges, and includes the flat (plane) region inside the boundary.
""" ;
  rdfs:subClassOf sio:GeometricEntity .

sio:PolyhedralSkeleton a owl:Class ;
  rdfs:comment "A polyhedral skeleton is a collection of polygon edges." ;
  rdfs:subClassOf sio:GeometricEntity .

sio:PolyhedralSurface a owl:Class ;
  rdfs:comment "A polyhedral surface is composed of polygonal faces." ;
  rdfs:subClassOf sio:GeometricEntity .

sio:Polyline a owl:Class ;
  rdfs:comment "A polyline is a connected sequence of line segments." ;
  rdfs:subClassOf sio:GeometricEntity .

sio:Polymer a owl:Class ;
  rdfs:comment "A polymer is a molecule composed of a connected set of monomeric residues." ;
  rdfs:subClassOf sio:Molecule .

sio:Polypeptide a owl:Class ;
  rdfs:comment """A polypeptide is an organic polymer composed of amino acid residues, typically of less than 50 amino acids in length.
""" ;
  rdfs:subClassOf sio:AminoAcidPolymer .

sio:PoorQuality a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QualityDescriptor .

sio:Population a owl:Class ;
  rdfs:comment """A population is all the organisms that both belong to the same group or species and live in the same geographical area.
""" ;
  rdfs:subClassOf sio:Collective .

sio:Position a owl:Class ;
  rdfs:comment """A measurement of a spatial location relative to a frame of reference or other objects.
""" ;
  rdfs:subClassOf sio:MeasurementValue .

sio:PositionalIdentifier a owl:Class ;
  rdfs:comment """A positional description is a description of location using some system or frame of reference.
""" ;
  rdfs:subClassOf sio:Identifier .

sio:PositionalRole a owl:Class ;
  rdfs:comment """A positional role is an abstract role which holds by comparing position to another object of reference.
""" ;
  rdfs:subClassOf sio:AbstractRole .

sio:PositionallyOrientedLine a owl:Class ;
  rdfs:comment """A positionally oriented line is a line that is positioned against some axis of reference.
""" ;
  rdfs:subClassOf sio:Line .

sio:Positive a owl:Class ;
  rdfs:comment """positive is an assertional qualifier that expresses the validity or truth of a basic assertion.
""" ;
  rdfs:subClassOf sio:AssertionalQualifier .

sio:PositiveCharge a owl:Class ;
  rdfs:comment "A positive charge is a charge where the value is positive." ;
  rdfs:subClassOf sio:CompleteCharge .

sio:PositiveEmotion a owl:Class ;
  rdfs:comment "A positive emotion is an emotion that feels good." ;
  rdfs:subClassOf sio:Emotion .

sio:PositiveNucleicAcidStrand a owl:Class ;
  rdfs:comment """The positive nucleic acid strand refers to the strand that is to be read 5' to 3'.
""" ;
  rdfs:subClassOf sio:NucleicAcidStrand .

sio:PostTranslationalModification a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:AminoAcidPolymerSubmolecule .

sio:PostalCode a owl:Class ;
  rdfs:comment """A postal code is a geographic coordinate composed of a series of letters and/or digits appended to a postal address for the purpose of sorting mail.
""" ;
  rdfs:subClassOf sio:GeographicPosition .

sio:PotassiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:PraseodymiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:PreMRna a owl:Class ;
  rdfs:comment """Precursor mRNA (pre-mRNA) is a single strand of messenger ribonucleic acid (mRNA) that is synthesized from a DNA template throught transcription.
""" ;
  rdfs:subClassOf sio:MessengerRna .

sio:Predicted a owl:Class ;
  rdfs:comment """predicted is the quality of an entity that is thought to exist, as evidenced by some rational procedure.
""" ;
  rdfs:subClassOf sio:Hypothetical .

sio:PredictedGene a owl:Class ;
  rdfs:comment """A predicted gene is a gene that was identified through computational method but has not been experimentally validated.
""" ;
  rdfs:subClassOf sio:Gene .

sio:Predicting a owl:Class ;
  rdfs:comment """predicting is the process of formulating a proposition about a state of affairs which might be realized in the future.
""" ;
  rdfs:subClassOf sio:Creating .

sio:PreferredName a owl:Class ;
  rdfs:comment "A preferred name is the name that is generally used by some organization. " ;
  rdfs:subClassOf sio:Name .

sio:Premise a owl:Class ;
  rdfs:comment "A premise is a proposition of an argument from which the conclusion is drawn." ;
  rdfs:subClassOf sio:Proposition .

sio:Pride a owl:Class ;
  rdfs:comment """pride is an emotion of satisfaction of attachment toward one's own or another's choices and actions, or toward a whole group of people, and is a product of praise, independent self-reflection, or a fulfilled feeling of belonging.
""" ;
  rdfs:subClassOf sio:Satisfaction .

sio:PrimaryActiveTransport a owl:Class ;
  rdfs:comment """primary active transport, also called direct active transport, directly uses energy to transport molecules across a membrane.
""" ;
  rdfs:subClassOf sio:ActiveTransport .

sio:PrimaryCategoryAxis a owl:Class ;
  rdfs:comment """A primary category axis is a category axis that either defines the sole value range or holds the larger set of categorical values specified by the secondary category axis.
""" ;
  rdfs:subClassOf sio:CategoryAxis .

sio:PrimaryDatabaseKey a owl:Class ;
  rdfs:comment "A primary database key is a database key that identifies every row of a table." ;
  rdfs:subClassOf sio:DatabaseKey .

sio:PrimaryGraphTitle a owl:Class ;
  rdfs:comment "A primary graph title is a primary title that describes a statistical graph." ;
  rdfs:subClassOf sio:PrimaryTitle .

sio:PrimaryStructureDescriptor a owl:Class ;
  rdfs:comment """A primary structure descriptor describes a biomolecular object in terms of a 1D or 2D topology.
""" ;
  rdfs:subClassOf sio:BiomolecularStructureDescriptor .

sio:PrimaryTitle a owl:Class ;
  rdfs:comment "A primary title is a title that should be first used in describing some entity." ;
  rdfs:subClassOf sio:Title .

sio:Primer a owl:Class ;
  rdfs:comment """A primer is a nucleic acid that enables the synthesis of a complement strand of DNA by binding to it and acting as a point of transcription initiation.
""" .

sio:ProbabilityMeasure a owl:Class ;
  rdfs:comment """A probability measure is quantity of how likely it is that some event will occur.
""" ;
  rdfs:subClassOf sio:DimensionlessQuantity .

sio:ProbabilityValue a owl:Class ;
  rdfs:comment """A p-value or probability value is the probability of obtaining a test statistic at least as extreme as the one that was actually observed, assuming that the null hypothesis is true
""" ;
  rdfs:subClassOf sio:ProbabilityMeasure .

sio:Procedure a owl:Class ;
  rdfs:comment """A procedure is a process that attempts to achieve one or more objectives by following an established set of actions.
""" ;
  rdfs:subClassOf sio:Process .

sio:Process a owl:Class ;
  rdfs:comment """A process is an entity that is identifiable only through the unfolding of time, has temporal parts, and unless otherwise specified/predicted, cannot be identified from any instant of time in which it exists.
""" ;
  rdfs:subClassOf sio:Entity , [
    a owl:Restriction ;
    owl:onProperty sio:has_participant ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_participant ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:ProcessDownRegulation a owl:Class ;
  rdfs:comment """process down-regulation is a process that decreases the frequency, rate or extent of one or more processes in relation to a reference state.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:ProcessMaintenance a owl:Class ;
  rdfs:comment """The process of maintaining some the frequency, rate or extent of another process.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:ProcessModel a owl:Class ;
  rdfs:comment "A process model is a representation of some process." ;
  rdfs:subClassOf sio:Model .

sio:ProcessNumber a owl:Class ;
  rdfs:comment """process number is a number associated with a process that denotes its ordinal position in a set of processes.
""" ;
  rdfs:subClassOf sio:OrdinalPosition .

sio:ProcessQuality a owl:Class ;
  rdfs:comment "A process quality is quality that is associated with a process." ;
  rdfs:subClassOf sio:Quality .

sio:ProcessStatus a owl:Class ;
  rdfs:comment "process status is a process quality that describes the state of a process." ;
  rdfs:subClassOf sio:ProcessQuality .

sio:ProcessUpRegulation a owl:Class ;
  rdfs:comment """process up-regulation is a process that increases the frequency, rate or extent of one or more processes in relation to a reference state.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:ProcessualRole a owl:Class ;
  rdfs:comment "A processual role is a role that can only be realized in a process." ;
  rdfs:subClassOf sio:Role .

sio:Product a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Molecule .

sio:ProductRole a owl:Class ;
  rdfs:comment "The role of a chemical entity present at the end of a chemical reaction." ;
  rdfs:subClassOf sio:MolecularEntityRole .

sio:Professor a owl:Class ;
  rdfs:comment "A professor is an individual that is a scholarly teacher." ;
  rdfs:subClassOf sio:Academic .

sio:ProfessorRole a owl:Class ;
  rdfs:comment """A professor role is the role of an individual that is involved in teaching of students (undergraduate and/or graduate) at a post-secondary academic institution.
""" ;
  rdfs:subClassOf sio:AcademicRole .

sio:Prognosis a owl:Class ;
  rdfs:comment """A prognosis is a proposition about the likely course of a disease, the chance of recovery or recurrence.
""" ;
  rdfs:subClassOf sio:Proposition .

sio:PromethiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Proposition a owl:Class ;
  rdfs:comment "A proposition is a sentence expressing something true or false." ;
  rdfs:subClassOf sio:Description .

sio:ProstheticGroupRole a owl:Class ;
  rdfs:comment "A coenzyme role of a chemical entity that is covalently bonded to the  enzyme." ;
  rdfs:subClassOf sio:CoEnzymeRole .

sio:ProtactiniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Protein a owl:Class ;
  rdfs:comment """A protein is an organic polymer that is composed of one or more linear polymers of amino acids.
""" ;
  rdfs:subClassOf sio:AminoAcidPolymer .

sio:ProteinCodingGene a owl:Class ;
  rdfs:comment "A gene that contains an open reading frame which codes for a protein." ;
  rdfs:subClassOf sio:Gene .

sio:ProteinCodingSequence a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:GeneComponent .

sio:ProteinComplex a owl:Class ;
  rdfs:comment """A protein complex is a molecular complex composed of at least two polypeptide chains.
""" ;
  rdfs:subClassOf sio:MolecularComplex .

sio:ProteinDomain a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:AminoAcidPolymerSubmolecule .

sio:ProteinExpressionValue a owl:Class ;
  rdfs:comment """A protein expression value is a quantity obtained from a protein expression experiment.
""" ;
  rdfs:subClassOf sio:DimensionalQuantity .

sio:ProteinFamily a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Collection .

sio:ProteinMediatedRegulationOfTranslation a owl:Class ;
  rdfs:comment """A process mediated by a protein that modulates the frequency, rate or extent of translation.
""" ;
  rdfs:subClassOf sio:RegulationOfTranslation .

sio:ProteinSequence a owl:Class ;
  rdfs:comment """A protein acid sequence is the character representation of the molecular structure of a protein.
""" ;
  rdfs:subClassOf sio:BiopolymerSequence .

sio:Province a owl:Class ;
  rdfs:comment """A province is a territorial unit, almost always an administrative division, within a country or state.
""" ;
  rdfs:subClassOf sio:GeopoliticalRegion .

sio:Pseudogene a owl:Class ;
  rdfs:comment """A pseudo gene is a region of a nucleic acid that either cannot be transcribed, or its RNA transcript cannot be translated.
""" ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Publication a owl:Class ;
  rdfs:comment "A publication is a document that has been made available by a publisher." ;
  rdfs:subClassOf sio:Document .

sio:PublisherRole a owl:Class ;
  rdfs:comment """A publisher role is the role of an individual that prepares and issues creative works.
""" ;
  rdfs:subClassOf sio:PublishingRole .

sio:PublishingRole a owl:Class ;
  rdfs:comment """A publishing role is the role of an individual that is involved in the preparation and issue of creative works for consumption by a wider audience.
""" ;
  rdfs:subClassOf sio:OccupationalRole .

sio:Purpose a owl:Class ;
  rdfs:comment """purpose is the reason for which something is done or created or for which something exists.
""" ;
  rdfs:subClassOf sio:Reason .

sio:Quadrilateral a owl:Class ;
  rdfs:comment """A quadrilateral is a polygon with composed of four points and four line segments, in which each point is fully connected to two other points.
""" ;
  rdfs:subClassOf sio:Polygon .

sio:Quality a owl:Class ;
  rdfs:comment """A quality is an attribute that is intrinsically associated with its bearer (or its parts), but whose presence/absence and observed/measured value may vary.
""" ;
  rdfs:subClassOf sio:Attribute , [
    a owl:Restriction ;
    owl:onProperty sio:is_quality_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_quality_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_base_for ;
    owl:allValuesFrom sio:RealizableEntity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_base_for ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:QualityDescriptor a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:InformationalQuality .

sio:Quantile a owl:Class ;
  rdfs:comment """A quantile is a quantity that divides the range of a probability distribution into continuous intervals with equal probabilities, or dividing the observations in a sample in the same way.
""" ;
  rdfs:subClassOf sio:DimensionlessQuantity .

sio:Quantity a owl:Class ;
  rdfs:comment "A quantity is an informational entity that gives the magnitude of a property." ;
  rdfs:subClassOf sio:MeasurementValue , [
    a owl:Restriction ;
    owl:onProperty sio:is_numerically_comparable_to ;
    owl:allValuesFrom sio:Quantity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_numerically_comparable_to ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:QuantityModifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:InformationalQuality .

sio:QuaternaryStructure a owl:Class ;
  rdfs:comment """A quaternary structure descriptor describes topological patterns in a multi-unit biopolymer complex.
""" ;
  rdfs:subClassOf sio:BiomolecularStructureDescriptor .

sio:Question a owl:Class ;
  rdfs:comment "A question is a linguistic expression used to make a request for information." ;
  rdfs:subClassOf sio:Sentence .

sio:Quote a owl:Class ;
  rdfs:comment "A quote is a excerpt that is attributed to a particular source." ;
  rdfs:subClassOf sio:Excerpt .

sio:RdfsOntology a owl:Class ;
  rdfs:comment """An RDFS ontology is an ontology that conforms to the syntax and semantics of the Resource Description Framework Schema (RDFS).
""" ;
  rdfs:subClassOf sio:OntologyDocument .

sio:RestWebService a owl:Class ;
  rdfs:comment """a REST web service is a web service that provides functionality according to the Representational State Transfer (REST) specification.
""" ;
  rdfs:subClassOf sio:WebService .

sio:RnaTranscript a owl:Class ;
  rdfs:comment """An RNA transcript is an RNA molecule that is produced from transcription of a nucleic acid template.
""" ;
  rdfs:subClassOf sio:RibonucleicAcid .

sio:RnaTranscriptComponent a owl:Class ;
  rdfs:comment "An RNA transcript component is a region of an RNA transcript. " ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Race a owl:Class ;
  rdfs:comment """race is a characteristic of an individual by heritable phenotypic characteristics, geographic ancestry, physical appearance, ethnicity, and social status.
""" ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:Radar a owl:Class ;
  rdfs:comment """A radar is an object-detection system which uses radio waves to determine the range, altitude, direction, or speed of objects.
""" ;
  rdfs:subClassOf sio:Device .

sio:RadioReceiver a owl:Class ;
  rdfs:comment """A radio receiver is a communication device that receives its input from an antenna, uses electronic filters to separate a wanted radio signal from all other signals picked up by this antenna, amplifies it to a level suitable for further processing, and finally converts through demodulation and decoding the signal into a form usable for the consumer, such as sound, pictures, digital data, measurement values, navigational positions.
""" ;
  rdfs:subClassOf sio:CommunicationDevice .

sio:RadiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:RadonAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Rage a owl:Class ;
  rdfs:comment """Rage is a feeling of intense anger that is associated with the Fight-or-flight response.
""" ;
  rdfs:subClassOf sio:Anger .

sio:RankNonzeroTensor a owl:Class ;
  rdfs:comment "a rank nonzero tensor is a tensor with a rank greater than zero." ;
  rdfs:subClassOf sio:Tensor .

sio:Rat a owl:Class ;
  rdfs:comment "A rat is a medium-sized, long-tailed rodent of the superfamily Muroidea." ;
  rdfs:subClassOf sio:MulticellularOrganism .

sio:RateOfChange a owl:Class ;
  rdfs:comment "The amount of change accumulated per unit time." ;
  rdfs:subClassOf sio:DimensionalQuantity .

sio:Ratio a owl:Class ;
  rdfs:comment """A ratio is a relationship between two numbers of the same kind expressed arithmetically as a dimensionless quotient of the two which explicitly indicates how many times the first number contains the second.
""" ;
  rdfs:subClassOf sio:DimensionlessQuantity .

sio:Ray a owl:Class ;
  rdfs:comment """A ray is a line which that is bounded by a startpoint and extends outwards infinitely along one dimension.
""" ;
  rdfs:subClassOf sio:Line .

sio:ReactantRole a owl:Class ;
  rdfs:comment "The role of a chemical entity present at the beginning of a chemical reaction." ;
  rdfs:subClassOf sio:MolecularEntityRole .

sio:Reagent a owl:Class ;
  rdfs:comment """A reagent is a substance that is added to a system in order to bring about a chemical reaction, or added to see if a reaction occurs.
""" ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:ReagentRole a owl:Class ;
  rdfs:comment """A role of a chemical substance that participates in a chemical reaction as part of some scientific investigation.
""" ;
  rdfs:subClassOf sio:ChemicalSubstanceRole .

sio:Real a owl:Class ;
  rdfs:comment "real is the quality of an entity that exists in real space and time." ;
  rdfs:subClassOf sio:ExistenceQuality .

sio:RealizableEntity a owl:Class ;
  rdfs:comment """A realizable entity is an attribute that is exhibited under some condition and is realized in some process.
""" ;
  rdfs:subClassOf sio:Attribute , [
    a owl:Restriction ;
    owl:onProperty sio:has_basis ;
    owl:allValuesFrom sio:Quality
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:has_basis ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Reason a owl:Class ;
  rdfs:comment """A reason is a justification that specifies the motive for an action or a determination.
""" ;
  rdfs:subClassOf sio:Justification .

sio:Reasoning a owl:Class ;
  rdfs:comment """reasoning is the agentive process of using knowledge to evaluate the truth value of a proposition.
""" ;
  rdfs:subClassOf sio:Creating .

sio:Receptor a owl:Class ;
  rdfs:comment """A receptor molecule is a molecule that has the capability to bind to a signal and propogate a response to that signal.
""" ;
  rdfs:subClassOf sio:SignalTransducer .

sio:Recipe a owl:Class ;
  rdfs:comment """A recipe is a set of instructions that describe how to prepare or make something.
""" ;
  rdfs:subClassOf sio:ActionSpecification .

sio:Record a owl:Class ;
  rdfs:comment "A record is a document containing a collection of statements about some entity." ;
  rdfs:subClassOf sio:Document .

sio:RecordIdentifier a owl:Class ;
  rdfs:comment "A record identifier is an identifier for a database entry." ;
  rdfs:subClassOf sio:InformationalEntityIdentifier .

sio:Rectangle a owl:Class ;
  rdfs:comment """A rectangle is a quadrilateral in which one pair of line segments are  parallel and the other pair are perpendicular to the first pair.
""" ;
  rdfs:subClassOf sio:Quadrilateral .

sio:RedoxReaction a owl:Class ;
  rdfs:comment """A redox reaction is a chemical reaction in which there is a net movement of electrons from one reactant to another.
""" ;
  rdfs:subClassOf sio:ChemicalReaction .

sio:Reference a owl:Class ;
  rdfs:comment """A reference is a textual entity that describes a single source used in the preparation or development of the work.
""" ;
  rdfs:subClassOf sio:DocumentComponent .

sio:ReferencingCell a owl:Class ;
  rdfs:comment """A referenceing cell is a cell of a cellular automata that refers to another cell.
""" ;
  rdfs:subClassOf sio:Cellinformational .

sio:ReferentCell a owl:Class ;
  rdfs:comment "A referent cell is a cell that is the referent of some function or pointer." ;
  rdfs:subClassOf sio:Cellinformational .

sio:Regret a owl:Class ;
  rdfs:comment """regret is a feeling of sadness, repentance, or disappointment over something that has happened or been done.
""" ;
  rdfs:subClassOf sio:Worry .

sio:Regulating a owl:Class ;
  rdfs:comment "regulating is a process that modulates the attributes of an object or process." ;
  rdfs:subClassOf sio:Interacting .

sio:RegulationOfBiochemicalProcess a owl:Class ;
  rdfs:comment """regulation of biochemical process is a process that changes the frequency, rate or extent of a target biochemical process.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:RegulationOfCapability a owl:Class ;
  rdfs:comment """regulation of capability is the regulation of the ability of one party by another.
""" ;
  rdfs:subClassOf sio:Regulating .

sio:RegulationOfCatalyticCapability a owl:Class ;
  rdfs:comment "the regulation of the enzymatic activity." ;
  rdfs:subClassOf sio:RegulationOfCapability .

sio:RegulationOfMolecularDegradation a owl:Class ;
  rdfs:comment """A process that modulates the frequency, rate or extent of process involved in the destruction of a molecule.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularQuantity .

sio:RegulationOfMolecularProduction a owl:Class ;
  rdfs:comment """A process that modulates the frequency, rate or extent of process involved in the production of a molecule.
""" ;
  rdfs:subClassOf sio:RegulationOfMolecularQuantity .

sio:RegulationOfMolecularQuantity a owl:Class ;
  rdfs:comment """A process that modulates the frequency, rate or extent of process involved in the creation or destruction of a molecule.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectQuantity .

sio:RegulationOfObjectConsumption a owl:Class ;
  rdfs:comment """A process that modulates the frequency, rate or extent of process involved in the consumption of an object.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectQuantity .

sio:RegulationOfObjectProduction a owl:Class ;
  rdfs:comment """regulation of a participant quantity is the regulation of a process in which the quantity of a selected participant is increased.
""" ;
  rdfs:subClassOf sio:RegulationOfObjectQuantity .

sio:RegulationOfObjectQuantity a owl:Class ;
  rdfs:comment """regulation of a participant quantity is the regulation of a process in which the quantity of its partcipants is changed.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:RegulationOfProcess a owl:Class ;
  rdfs:comment """regulation of a process is a process that modulates the duration, frequency, spatial extent of a target process.
""" ;
  rdfs:subClassOf sio:Regulating .

sio:RegulationOfProcessDuration a owl:Class ;
  rdfs:comment """regulation of a process duration is a process that modulates the duration of another process relative to some reference process.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:RegulationOfProcessFrequency a owl:Class ;
  rdfs:comment """regulation of a process duration is a process that modulates the frequency of another process relative to some reference process.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:RegulationOfProcessSpatialExtent a owl:Class ;
  rdfs:comment """regulation of a process spatial extent is a process that modulates the spatial extent of another process relative to some reference process.
""" ;
  rdfs:subClassOf sio:RegulationOfProcess .

sio:RegulationOfTranscription a owl:Class ;
  rdfs:comment "A process that modulates the frequency, rate or extent of transcription." ;
  rdfs:subClassOf sio:RegulationOfBiochemicalProcess .

sio:RegulationOfTranslation a owl:Class ;
  rdfs:comment "A process that modulates the frequency, rate or extent of translation." ;
  rdfs:subClassOf sio:RegulationOfBiochemicalProcess .

sio:RegulatorRole a owl:Class ;
  rdfs:comment "The role of a chemical entity that modifies the rate of reaction." ;
  rdfs:subClassOf sio:MolecularEntityRole .

sio:RegulatoryAuthority a owl:Class ;
  rdfs:comment """A regulatory authority is an organization responsible for  exercising regulatory or supervisory capacity in some area of human activity.
""" ;
  rdfs:subClassOf sio:Organization .

sio:RegulatoryPathway a owl:Class ;
  rdfs:comment """A regulatory pathway is a series of biochemical reactions that lead to the increase or decrease of activity of participating molecular components.
""" ;
  rdfs:subClassOf sio:BiochemicalPathway .

sio:Remorse a owl:Class ;
  rdfs:comment """remorse is an emotion of personal regret felt by a person after he or she has committed an act which they deem to be shameful, hurtful, or violent.
""" ;
  rdfs:subClassOf sio:Regret .

sio:ReplicaQuality a owl:Class ;
  rdfs:comment """replica quality is the quality of an object that is an exact copy of another object.
""" ;
  rdfs:subClassOf sio:ObjectRelationalQuality .

sio:Replicate a owl:Class ;
  rdfs:comment """a replicate is an object that is a facsimile, reproduction, or copy of another item.
""" ;
  rdfs:subClassOf sio:CollectionItem .

sio:ReplicateRole a owl:Class ;
  rdfs:comment """a replicate role is a comparative role that holds  when one item is a reproduction, facsimile, or a copy of another.
""" ;
  rdfs:subClassOf sio:ComparativeRole .

sio:Report a owl:Class ;
  rdfs:comment """A report is a textual document made that present focused, salient content to a specific audience.
""" ;
  rdfs:subClassOf sio:Document .

sio:Representation a owl:Class ;
  rdfs:comment """A representation is a entity that in some way represents another entity (or attribute thereof).
""" ;
  rdfs:subClassOf sio:InformationContentEntity .

sio:Reproducing a owl:Class ;
  rdfs:comment """reproducing is a process characterized by creation of an entity that is similar or exactly the same as the template from which it is derived.
""" ;
  rdfs:subClassOf sio:Creating .

sio:Resentment a owl:Class ;
  rdfs:comment "resentment is disgust directed toward a higher status individual." ;
  rdfs:subClassOf sio:Disgust .

sio:ResultsSection a owl:Class ;
  rdfs:comment """The results section is a document section describing the main findings of the study.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:Reviewed a owl:Class ;
  rdfs:comment """reviewed is the quality of a textual entity that has been examined and commented on by another party.
""" ;
  rdfs:subClassOf sio:Written .

sio:RevisionNumber a owl:Class ;
  rdfs:comment """A revision number is a version of a software in which bugs have been fixed from a prior version.
""" ;
  rdfs:subClassOf sio:SoftwareVersionLabel .

sio:RheniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:RhodiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:RibonucleicAcid a owl:Class ;
  rdfs:comment """A ribonucleic acid is an organic polymer composed of a sequence of ribonucleotide residues.
""" ;
  rdfs:subClassOf sio:NucleicAcid .

sio:RibonucleicAcidSequence a owl:Class ;
  rdfs:comment """A ribonucleic acid sequence is a symbolic representation of the sequence of ribonucleic acid residues in a ribonucleic acid.
""" ;
  rdfs:subClassOf sio:NucleicAcidSequence .

sio:RibonucleotideResidue a owl:Class ;
  rdfs:comment """A ribonucleotide residue is a part of a molecule that derives from a ribonucleotide.
""" ;
  rdfs:subClassOf sio:NucleotideResidue .

sio:RibosomalRnaGene a owl:Class ;
  rdfs:comment "A ribosomal RNA gene is a gene that codes for a ribosomal RNA molecule." ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRnaGene .

sio:RightHandedHelical a owl:Class ;
  rdfs:comment """right-handed helical quality is the quality in which a clockwise screwing motion moves the helix away from the observed along the line of sight along the helix's axis.
""" ;
  rdfs:subClassOf sio:Helicity .

sio:RightClosedInterval a owl:Class ;
  rdfs:comment """a right closed interval is an interval in which there is a real number that is larger than all of its elements.
""" ;
  rdfs:subClassOf sio:Interval .

sio:RightOpenInterval a owl:Class ;
  rdfs:comment """a right open interval is an interval in which there is no element that is greater than all other elements.
""" ;
  rdfs:subClassOf sio:Interval .

sio:RightValueAxis a owl:Class ;
  rdfs:comment """A right value axis is a value axis that is spatially positioned to the right of the plot area.
""" ;
  rdfs:subClassOf sio:ValueAxis .

sio:Rigid a owl:Class ;
  rdfs:comment """rigid is the quality of maintaining structural integrity (and not bending) under pressure.
""" ;
  rdfs:subClassOf sio:StructuralQuality .

sio:Ring a owl:Class ;
  rdfs:comment "A ring is a submolecule with a circular topology." ;
  rdfs:subClassOf sio:ChemicalFunctionalGroup .

sio:RnaGene a owl:Class ;
  rdfs:comment "A gene that is located on RNA." ;
  rdfs:subClassOf sio:Gene .

sio:RnaMediatedRegulationOfTranslation a owl:Class ;
  rdfs:comment """A process mediated by rna that modulates the frequency, rate or extent of translation.
""" ;
  rdfs:subClassOf sio:RegulationOfTranslation .

sio:RoentgeniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Role a owl:Class ;
  rdfs:comment """A role is a realizable entity that describes behaviours, rights and obligations of an entity in some particular circumstance.
""" ;
  rdfs:subClassOf sio:RealizableEntity , [
    a owl:Restriction ;
    owl:onProperty sio:is_role_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_role_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:Row a owl:Class ;
  rdfs:comment "A row represents a single, implicitly structured data item in a table. " ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:RubidiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:RutheniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:RutherfordiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:SadiSemanticWebService a owl:Class ;
  rdfs:comment """a SADI semantic web service is a semantic web service that follows the SADI specification
""" ;
  rdfs:subClassOf sio:SemanticWebService .

sio:SadiWebServiceInvocation a owl:Class ;
  rdfs:comment "A SADI web service invocation is the excution of a SADI web service." ;
  rdfs:subClassOf sio:WebServiceInvocation .

sio:SoapWebService a owl:Class ;
  rdfs:comment """a SOAP web service is a web service that implements Simple Object Access Protocol (SOAP).
""" ;
  rdfs:subClassOf sio:WebService .

sio:Sadness a owl:Class ;
  rdfs:comment """sadness is emotional pain associated with, or characterized by feelings of disadvantage, loss, despair, helplessness, sorrow, and rage.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:SamariumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Sample a owl:Class ;
  rdfs:comment """A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use.
""" ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:SampleQuality a owl:Class ;
  rdfs:comment """sample quality is the quality of an object that is drawn from a larger population.
""" ;
  rdfs:subClassOf sio:ObjectRelationalQuality .

sio:Sampling a owl:Class ;
  rdfs:comment """sampling is the act of obtaining a sample, whether through selection, collection or preparation.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:Satisfaction a owl:Class ;
  rdfs:comment """satisfaction is an emotion of fulfillment of one's wishes, expectations, or needs, or the pleasure derived from this.
""" ;
  rdfs:seeAlso sio:PositiveEmotion ;
  rdfs:subClassOf sio:Contentment .

sio:SatisfactionQualifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:InformationalQuality .

sio:SatisfiedQualifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:SatisfactionQualifier .

sio:Scalar a owl:Class ;
  rdfs:comment """a scalar is a rank 0 tensor and is an element of a field that is used to define a vector space.
""" ;
  rdfs:subClassOf sio:Tensor .

sio:ScaledValueAxis a owl:Class ;
  rdfs:comment """A scaled value axis is a value axis in which the value range was subject to a mathematic transformation.
""" ;
  rdfs:subClassOf sio:ValueAxis .

sio:ScandiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Scatterplot a owl:Class ;
  rdfs:comment """A scatterplot is a statistical graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis.
""" ;
  rdfs:subClassOf sio:StatisticalGraph .

sio:ScientificData a owl:Class ;
  rdfs:comment "scientific data is data obtained from some scientific procedure." ;
  rdfs:subClassOf sio:DataItem .

sio:ScientificName a owl:Class ;
  rdfs:comment "A scientific name is a name given through scientific nomenclature." ;
  rdfs:subClassOf sio:Name .

sio:SeaborgiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Second a owl:Class ;
  rdfs:comment """A second (symbol: s) is the base unit of time in the International System of Units (SI) and is the second division of the hour by sixty, the first division by 60 being the minute.
""" ;
  rdfs:subClassOf sio:TimeInterval .

sio:SecondMessenger a owl:Class ;
  rdfs:comment """A second messenger is a molecule that relay signals from receptors on the cell surface to target molecules inside the cell, in the cytoplasm or nucleus. 
""" ;
  rdfs:subClassOf sio:Messenger .

sio:SecondaryActiveTransport a owl:Class ;
  rdfs:comment """secondary active transport or co-transport uses electrochemical potential difference created by pumping ions out of the cell to transport molecules across a membrane.
""" ;
  rdfs:subClassOf sio:ActiveTransport .

sio:SecondaryCategoryAxis a owl:Class ;
  rdfs:comment """A secondary category axis is a category axis that defines a finer granular part (or subset) of the value range of the primary category axis.
""" ;
  rdfs:subClassOf sio:CategoryAxis .

sio:SecondaryGraphTitle a owl:Class ;
  rdfs:comment "A secondary graph title is a secondary title that describes a statistical graph." ;
  rdfs:subClassOf sio:PrimaryTitle .

sio:SecondaryStructureDescriptor a owl:Class ;
  rdfs:comment """A secondary structure descriptor describes local topological patterns in  a biopolymer.
""" ;
  rdfs:subClassOf sio:BiomolecularStructureDescriptor .

sio:SecondaryTitle a owl:Class ;
  rdfs:comment """A secondary title is a title of lesser importance that should be used after the first title in describing some entity.
""" ;
  rdfs:subClassOf sio:Title .

sio:SecretaryRole a owl:Class ;
  rdfs:comment """A secretary role is the role of an individual that performs administrative tasks to support one or more individuals of the same organization.
""" ;
  rdfs:subClassOf sio:AdministrativeRole .

sio:SeleniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:SemanticWebService a owl:Class ;
  rdfs:comment """a semantic web service is a web service that provides a formal, machine understanble description of its functionality.
""" ;
  rdfs:subClassOf sio:WebService .

sio:Sentence a owl:Class ;
  rdfs:comment """A sentence is a grammatical unit consisting of one or more words that bear minimal syntactic relation to the words that precede or follow it.
""" ;
  rdfs:subClassOf sio:Phrase .

sio:Sequence a owl:Class ;
  rdfs:comment """A sequence is an ordered list of entities. Like a set, it contains members (also called elements, or terms).
""" ;
  rdfs:subClassOf sio:List .

sio:SequenceAlignment a owl:Class ;
  rdfs:comment """A sequence alignment is the character-based alignment of sequences using some method.
""" ;
  rdfs:subClassOf sio:Collection .

sio:SequenceAssembly a owl:Class ;
  rdfs:comment """A sequence assembly is a sequence that is produced as by the alignment of two or more sequences.
""" ;
  rdfs:subClassOf sio:BiopolymerSequence .

sio:SequenceElementPosition a owl:Class ;
  rdfs:comment "A sequence element position is the position of an element of a linear sequence." ;
  rdfs:subClassOf sio:LinearPosition .

sio:SequenceEndPosition a owl:Class ;
  rdfs:comment """A sequence end position is the position of the last character in a sequence of characters relative to some linear frame of reference.
""" ;
  rdfs:seeAlso sio:SequenceElementPosition ;
  rdfs:subClassOf sio:EndPosition .

sio:SequenceMotif a owl:Class ;
  rdfs:comment """A sequence motif is a pattern of nucleotides in a DNA sequence or amino acids in a protein.
""" ;
  rdfs:subClassOf sio:Pattern .

sio:SequenceProfile a owl:Class ;
  rdfs:comment """A sequence profile is provides the preference for a character at each position of an abstracted sequence.
""" ;
  rdfs:subClassOf sio:Pattern .

sio:SequenceStartPosition a owl:Class ;
  rdfs:comment "A sequence start position is the start position for a sequence of characters." ;
  rdfs:seeAlso sio:StartPosition ;
  rdfs:subClassOf sio:SequenceElementPosition .

sio:SequenceVariantRole a owl:Class ;
  rdfs:comment """A sequence variant role is a comparative role in which the composition of characters in a sequence differs when compared to another entity of similar type.
""" ;
  rdfs:subClassOf sio:VariantRole .

sio:SequenceVariationNotation a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Notation .

sio:Set a owl:Class ;
  rdfs:comment "A set is a collection of entities, for which there may be zero members." ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:SetItem a owl:Class ;
  rdfs:comment "set item is an item in a set." ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:Severe a owl:Class ;
  rdfs:comment """severe is a qualitative intensity value that is more intense than strong, but less intense than fatal.
""" ;
  rdfs:subClassOf sio:Intensity .

sio:Shame a owl:Class ;
  rdfs:comment """shame is the emotion borne from feeling responsible for the commission of an offense.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Shape a owl:Class ;
  rdfs:comment "shape is the quality of a bearer that relates to its spatial extent." ;
  rdfs:subClassOf sio:ObjectQuality .

sio:Shock a owl:Class ;
  rdfs:comment "shock is an emotion of sudden upset or surprise." ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Shyness a owl:Class ;
  rdfs:comment """shyness is an emotion of apprehension, lack of comfort, or awkwardness experienced when in proximity to, approaching, or being approached by other individuals, especially in new situations or with unfamiliar individuals.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:Sick a owl:Class ;
  rdfs:comment "sick is the status of a living organism that is behaving at a sub-optimal level." ;
  rdfs:subClassOf sio:Alive .

sio:SignLanguage a owl:Class ;
  rdfs:comment """A sign language (also signed language) is a language that involves manual communication and body language to convey meaning. This can involve simultaneously combining hand shapes, orientation and movement of the hands, arms or body, and facial expressions to fluidly express a speaker's thoughts.
""" ;
  rdfs:subClassOf sio:Language .

sio:Signal a owl:Class ;
  rdfs:comment "A signal is an object that initiates a sequence of events." ;
  rdfs:subClassOf sio:Molecule .

sio:SignalTransducer a owl:Class ;
  rdfs:comment """A signal transducer is a molecule that responds to and amplifies a signal in a signalling system.
""" ;
  rdfs:subClassOf sio:Molecule .

sio:SiliconAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:SilverAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:SingleArrowedLineSegment a owl:Class ;
  rdfs:comment """A single arrowed line is directed line in which the endpoint is tangentially part of a triangle that bisects the line.
""" ;
  rdfs:subClassOf sio:ArrowedLineSegment .

sio:SingleBond a owl:Class ;
  rdfs:comment """A single bond is a covalent bond between a pair of atoms in which one pair of electrons are shared.
""" ;
  rdfs:subClassOf sio:CovalentBond .

sio:SingleDisplacementReaction a owl:Class ;
  rdfs:comment """A single displacement reaction where one atom is transferred out of one molecule and into another.
""" ;
  rdfs:subClassOf sio:DisplacementReaction .

sio:SingleNucleotidePolymorphism a owl:Class ;
  rdfs:comment """a single nucleotide variation (SNV) is a nucleotide residue that is a variant compared to some reference nucleic acid sequence.
""" ;
  rdfs:subClassOf sio:NucleotideResidue .

sio:Site a owl:Class ;
  rdfs:comment """A site is a spatial region bounded (in part or in whole) by material entities and may be occupied by material entities.
""" ;
  rdfs:subClassOf sio:SpatialRegion .

sio:Slide a owl:Class ;
  rdfs:comment "A slide is an visual representation meant to communicate some information." ;
  rdfs:subClassOf sio:Media .

sio:Slideshow a owl:Class ;
  rdfs:comment """A slideshow is a visual presentation of information contained within a collection of slides.
""" ;
  rdfs:subClassOf sio:Media .

sio:Slope a owl:Class ;
  rdfs:comment """A slope or gradient of a line describes its steepness, incline, or grade. A higher slope value indicates a steeper incline. Slope is normally described by the ratio of the \"rise\" divided by the \"run\" between two points on a line.
""" ;
  rdfs:subClassOf sio:Ratio .

sio:SmallCytoplasmicRnAscRna a owl:Class ;
  rdfs:comment """A small cytoplasmic RNA (scRNA) molecule is a small (7S; 129 nucleotides) RNA molecule found in the cytosol and rough endoplasmic reticulum that are normally associated with proteins that are involved in specific selection and transport of other proteins.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRna .

sio:SmallCytoplasmicRnAscRnaGene a owl:Class ;
  rdfs:comment """A small cytoplasmic RNA (scRNA) gene is a gene that encodes a small (7S; 129 nucleotides) RNA molecule found in the cytosol and rough endoplasmic reticulum that are normally associated with proteins that are involved in specific selection and transport of other proteins.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRnaGene .

sio:SmallNuclearRnAsnRna a owl:Class ;
  rdfs:comment """A small nuclear RNA (snRNA) is a small RNA molecule that is located in the nucleus of a cell.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRna .

sio:SmallNuclearRnAsnRnaGene a owl:Class ;
  rdfs:comment """A small nuclear RNA (snRNA) gene is a gene that encodes a small niuclear RNA molecule.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRnaGene .

sio:SmallNucleolarRnAsnoRna a owl:Class ;
  rdfs:comment """A small nucleolar RNA (snoRNA) is a small RNA that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRna .

sio:SmallNucleolarRnAsnoRnaGene a owl:Class ;
  rdfs:comment """A small nucleolar RNA (snoRNA) gene is a gene that encodes a small RNA that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRnaGene .

sio:SocialEntity a owl:Class ;
  rdfs:comment "A social entity pertains to the interaction among individuals and groups." ;
  rdfs:subClassOf sio:InformationContentEntity .

sio:SocialRelation a owl:Class ;
  rdfs:comment """A social relation is a social entity that describes a relationship  between two or more individuals or groups.
""" ;
  rdfs:subClassOf sio:SocialEntity .

sio:SocialRole a owl:Class ;
  rdfs:comment "A social role is a role that is ascribed to individuals in a community." ;
  rdfs:subClassOf sio:Role .

sio:SocialStructure a owl:Class ;
  rdfs:comment """A social structure is a social entity which consists of relationships between two or more entities.
""" ;
  rdfs:subClassOf sio:SocialEntity .

sio:SodiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:SoftwareApplication a owl:Class ;
  rdfs:comment """A software application is software that can be directly executed by some processing unit.
""" ;
  rdfs:subClassOf sio:SoftwareEntity .

sio:SoftwareEntity a owl:Class ;
  rdfs:comment """A software entity is a computational entity that can be interpreted by or directly executed by a processing unit.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:SoftwareInterpreter a owl:Class ;
  rdfs:comment """A software interpreter is a software application that executes some specified input software.
""" ;
  rdfs:subClassOf sio:SoftwareApplication .

sio:SoftwareLibrary a owl:Class ;
  rdfs:comment """A software library is software composed of a collection of software modules and/or software methods in a form that can be statically or dynamically linked to some software application.
""" ;
  rdfs:subClassOf sio:SoftwareEntity .

sio:SoftwareMethod a owl:Class ;
  rdfs:comment """A software method (also called subroutine, subprogram, procedure, method, function, or routine) is software designed to execute a specific task.
""" ;
  rdfs:subClassOf sio:SoftwareEntity .

sio:SoftwareModule a owl:Class ;
  rdfs:comment "A software module is software composed of a collection of software methods." ;
  rdfs:subClassOf sio:SoftwareEntity .

sio:SoftwareProcessIdentifier a owl:Class ;
  rdfs:comment """A software process identifier is an identifier for a software process in some operating system.
""" ;
  rdfs:subClassOf sio:InformationalEntityIdentifier .

sio:SoftwareScript a owl:Class ;
  rdfs:comment """A software script is software whose instructions can be executed using a software interpreter.
""" ;
  rdfs:subClassOf sio:SoftwareEntity .

sio:SoftwareVersionLabel a owl:Class ;
  rdfs:comment "A software version label is a version label for a piece of software." ;
  rdfs:subClassOf sio:VersionLabel .

sio:SofwareExecution a owl:Class ;
  rdfs:comment "software execution is the process of executing software on a computing device." ;
  rdfs:subClassOf sio:InformationProcessing .

sio:SolidStateHardDrive a owl:Class ;
  rdfs:comment """A solid-state drive (SSD) is a data storage device that uses solid-state memory to store persistent data.
""" ;
  rdfs:subClassOf sio:HardDiskDrive .

sio:Solute a owl:Class ;
  rdfs:comment "A solute is a substance that becomes dissolved in a solvent." ;
  rdfs:subClassOf sio:LiquidSolutionComponent .

sio:Solvent a owl:Class ;
  rdfs:comment "A solvent is a substance that can dissolve other substances (solutes)." ;
  rdfs:subClassOf sio:LiquidSolutionComponent .

sio:SomeOfTheTime a owl:Class ;
  rdfs:comment "some refers to in the minority of occasions" ;
  rdfs:subClassOf sio:TemporalQualifier .

sio:Sorrow a owl:Class ;
  rdfs:comment """sorrow is the emotion that is characterized by a long term state of intense sadness, distress and a degree of resignation (not accepting).
""" ;
  rdfs:subClassOf sio:Sadness .

sio:SoundArgument a owl:Class ;
  rdfs:comment "A sound argument is a valid argument with true premises." ;
  rdfs:subClassOf sio:ValidArgument .

sio:SoundWave a owl:Class ;
  rdfs:comment """A sound wave is a mechanical wave that is an oscillation of pressure transmitted through a solid, liquid, or gas, composed of frequencies within the range of hearing.
""" ;
  rdfs:subClassOf sio:Wave .

sio:SpatialBoundary a owl:Class ;
  rdfs:comment """A spatial boundary is the closure minus the interior of a subset of a topological space.
""" ;
  rdfs:subClassOf sio:SpatialRegion .

sio:SpatialQuantity a owl:Class ;
  rdfs:comment """A spatial quantity is a quantity obtained from measuring the spatial extent of an entity 
""" ;
  rdfs:subClassOf sio:DimensionalQuantity .

sio:SpatialRegion a owl:Class ;
  rdfs:comment "A spatial region is an object contained in some region of space." ;
  rdfs:subClassOf sio:Object .

sio:SpatialSpecification a owl:Class ;
  rdfs:comment """A specification for spatial location is an effective specification towards representation spatial position or spatial data.
""" ;
  rdfs:subClassOf sio:FunctionalSpecification .

sio:SpecializedMaterialEntity a owl:Class ;
  rdfs:comment """A specialized material entity is a material entity that is defined by having some quality, role or capability.
""" ;
  rdfs:subClassOf sio:SpecializedObject .

sio:SpecializedObject a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Object .

sio:SpecificGravity a owl:Class ;
  rdfs:comment """Specific gravity is the ratio of the density of a substance to the density of a reference substance; equivalently, it is the ratio of the mass of a substance to the mass of a reference substance for the same given volume.
""" ;
  rdfs:subClassOf sio:Ratio .

sio:Specification a owl:Class ;
  rdfs:comment """A specification is a description of the essential technical attributes/requirements for an object or procedure, and may be used to determine that the object / procedure meets its requirements/attributes.
""" ;
  rdfs:subClassOf sio:Description .

sio:Specimen a owl:Class ;
  rdfs:comment "A specimen is a portion of material for use in testing, examination, or study." ;
  rdfs:subClassOf sio:Sample .

sio:Speculation a owl:Class ;
  rdfs:comment "speculation is an opinion based on incomplete evidence." ;
  rdfs:subClassOf sio:Opinion .

sio:Speech a owl:Class ;
  rdfs:comment "speech is the expression of thoughts and feelings by sound." ;
  rdfs:subClassOf sio:Communicating .

sio:Speed a owl:Class ;
  rdfs:comment "Speed is the rate of change of an object's position." ;
  rdfs:subClassOf sio:RateOfChange .

sio:SphericalCoordinateSystem a owl:Class ;
  rdfs:comment """A spherical coordinate system is a coordinate system for three-dimensional space where the position of a point is specified by three numbers: the radial distance of that point from a fixed origin, its polar angle measured from a fixed zenith direction, and the azimuth angle of its orthogonal projection on a reference plane that passes through the origin and is orthogonal to the zenith, measured from a fixed reference direction on that plane.
""" ;
  rdfs:subClassOf sio:CoordinateSystem .

sio:SpliceSite a owl:Class ;
  rdfs:comment """A splice site is a region required for the excision of an intron and connection to another exon.
""" ;
  rdfs:subClassOf sio:RnaTranscriptComponent .

sio:StackGraph a owl:Class ;
  rdfs:comment """A stack graph is a statistical graph which presents multiple series in which the distance between one series and another indicates the relative contribution to the total for any x-value.
""" ;
  rdfs:subClassOf sio:StatisticalGraph .

sio:StackedBarGraph a owl:Class ;
  rdfs:comment """A stacked bar graph is a bar graph in which each rectangular bar is partioned by the categorical value of each series of data.
""" ;
  rdfs:subClassOf sio:BarGraph .

sio:Standard a owl:Class ;
  rdfs:comment "A standard is a socially-agreed upon specification." ;
  rdfs:subClassOf sio:Specification .

sio:StandardDeviation a owl:Class ;
  rdfs:comment """A standard deviation (represented by the symbol σ) is the quantity of  variation from the average (mean, or expected value).
""" ;
  rdfs:subClassOf sio:Quantity .

sio:StandardOperatingProcedure a owl:Class ;
  rdfs:comment """A standard operating procedure is a specification approved for use in specific environments.
""" ;
  rdfs:subClassOf sio:ExperimentalProtocol .

sio:StandardScore a owl:Class ;
  rdfs:comment """A standard score is the (signed) number of standard deviations an observation or datum is above the mean. 
""" ;
  rdfs:subClassOf sio:ProbabilityMeasure .

sio:StartCodon a owl:Class ;
  rdfs:comment """A start codon is the first codon of a messenger RNA (mRNA) transcript translated by a ribosome. The start codon is almost always preceded by an untranslated region 5' UTR.
""" ;
  rdfs:subClassOf sio:RnaTranscriptComponent .

sio:StartDate a owl:Class ;
  rdfs:comment """A start date is a time instant pertaining to the date of the beginning of a process.
""" ;
  rdfs:subClassOf sio:TimeInstant .

sio:StartPoint a owl:Class ;
  rdfs:comment """A start point is a terminal point which is the first of an ordered 
pair of points.
""" ;
  rdfs:subClassOf sio:TerminalPoint .

sio:StartPosition a owl:Class ;
  rdfs:comment """A start position is the proximal position of an object relative to an origin in a linear system.
""" ;
  rdfs:subClassOf sio:LinearPosition .

sio:StartTime a owl:Class ;
  rdfs:comment "A start time is a time instant pertaining to the time at which a process begins." ;
  rdfs:subClassOf sio:TimeInstant .

sio:State a owl:Class ;
  rdfs:comment """A state is a set of governing and supportive institutions that have sovereignty over a definite territory and population.
""" ;
  rdfs:subClassOf sio:GeopoliticalRegion .

sio:Statement a owl:Class ;
  rdfs:comment """A statement is a proposition that is either (a) a meaningful declarative sentence that is either true or false, or (b) that which a true or false declarative sentence asserts.
""" ;
  rdfs:subClassOf sio:Proposition .

sio:StatementOfConsequence a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Statement .

sio:StationaryPoint a owl:Class ;
  rdfs:comment """A stationary point is a point that is part of a curve in which the derivative at that point is zero, and hence its value is at least a local maximum or minimum.
""" ;
  rdfs:subClassOf sio:DataPoint .

sio:StatisticalAssociation a owl:Class ;
  rdfs:comment """A statistical association is any relationship between two measured quantities that renders them statistically dependent.
""" ;
  rdfs:subClassOf sio:Association .

sio:StatisticalGraph a owl:Class ;
  rdfs:comment """A statistical graph is a figure that displays the relationship among numeric data and/or mathematical functions.
""" ;
  rdfs:subClassOf sio:Chart .

sio:StatisticalGraphLine a owl:Class ;
  rdfs:comment """A statistical graph line is a line used in a statistical graph to communicate some trend or feature of the embedded data.
""" ;
  rdfs:subClassOf sio:Line .

sio:StatusDescriptor a owl:Class ;
  rdfs:comment "status descriptor is a descriptor for the state of a process or object." ;
  rdfs:subClassOf sio:InformationalQuality .

sio:Statute a owl:Class ;
  rdfs:comment """A statute is a formal written enactment of a legislative authority that governs a state, city or country.
""" ;
  rdfs:subClassOf sio:LegalDocument .

sio:Stereoisomer a owl:Class ;
  rdfs:comment """A stereoisomer is an isomer in which the atomic connectivity is the same, but differs in its spatial arrangement of atoms.
""" ;
  rdfs:subClassOf sio:Isomer .

sio:StopCodon a owl:Class ;
  rdfs:comment """A stop codon (or termination codon) is a nucleotide triplet within messenger RNA that signals a termination of translation.
""" ;
  rdfs:subClassOf sio:RnaTranscriptComponent .

sio:Straight a owl:Class ;
  rdfs:comment "straight is a quality of a bearer that is free of curves, bends, or angles." ;
  rdfs:subClassOf sio:Curvature .

sio:Strain a owl:Class ;
  rdfs:comment "A strain is a genetic variant or kind of microorganism." ;
  rdfs:subClassOf sio:Organism .

sio:Streamgraph a owl:Class ;
  rdfs:comment """A streamgraph is a multi-line stacked graph that yields the appearance of continuous y-values across the x-axis.
""" ;
  rdfs:subClassOf sio:StackGraph .

sio:StreetName a owl:Class ;
  rdfs:comment "A street name is the token given to identify a particular street." ;
  rdfs:subClassOf sio:PositionalIdentifier .

sio:Strong a owl:Class ;
  rdfs:comment """strong is a qualitative intensity value that is more intense than moderate, but less intense than severe.
""" ;
  rdfs:subClassOf sio:Intensity .

sio:StrongChemicalSalt a owl:Class ;
  rdfs:comment """a strong chemical salt is a chemical salt that is composed of strong electrolytes. Strong chemical salts contain Na,K,NH4 or NO3, CIO4, CH3COO.
""" ;
  rdfs:subClassOf sio:ChemicalSalt .

sio:StrongSubmolecularComponent a owl:Class ;
  rdfs:comment """A strong submolecular component is a submolecular component that strongly connects submolecular components.
""" ;
  rdfs:subClassOf sio:SubmolecularEntity .

sio:StrontiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:StructuralIsomer a owl:Class ;
  rdfs:comment """A structural isomer is an isomer in which the atoms are joined together in different ways.
""" ;
  rdfs:subClassOf sio:Isomer .

sio:StructuralMotif a owl:Class ;
  rdfs:comment """A structural motif is a pattern in a structure formed by a spatial arrangement of objects (e.g. atoms).
""" ;
  rdfs:subClassOf sio:Pattern .

sio:StructuralQuality a owl:Class ;
  rdfs:comment "A structural quality is a quality of an object that describes its structure." ;
  rdfs:subClassOf sio:ObjectQuality .

sio:Structure a owl:Class ;
  rdfs:comment """structure is the specification that refers to the composition and arrangement of parts of an object.
""" ;
  rdfs:subClassOf sio:FunctionalSpecification .

sio:Student a owl:Class ;
  rdfs:comment "A student is an individual who is attends an educational institution." ;
  rdfs:subClassOf sio:Academic .

sio:StudentAdvisorRole a owl:Class ;
  rdfs:comment """A student advisor role is the role of an individual employed at an academic organization that is involved in advising students.
""" ;
  rdfs:subClassOf sio:AcademicRole .

sio:StudentRole a owl:Class ;
  rdfs:comment """A student role is the role of an individual that is enrolled in courses at an academic institution.
""" ;
  rdfs:subClassOf sio:AcademicRole .

sio:Study a owl:Class ;
  rdfs:comment "A study is a process that realizes the steps of a study design." ;
  rdfs:subClassOf sio:Investigation .

sio:StudyDesign a owl:Class ;
  rdfs:comment """A study design is a protocol for the proper execution of a study which normally requires a carefullly crafted research question or hypothesis and at least one variable under observation and observed values for that variable.
""" ;
  rdfs:subClassOf sio:ExperimentalProtocol .

sio:StudyGroup a owl:Class ;
  rdfs:comment """A study group is a group of individuals that are subjects in an observational or intervention study.
""" ;
  rdfs:subClassOf sio:Collective .

sio:StudySubject a owl:Class ;
  rdfs:comment "A study subject is an individual that is the subject of the study." ;
  rdfs:subClassOf sio:Person .

sio:SubcellularEntity a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:SubjectRole a owl:Class ;
  rdfs:comment "A subject role is the role of an individual that is the target of the study." ;
  rdfs:subClassOf sio:InvestigationalRole .

sio:SubmolecularEntity a owl:Class ;
  rdfs:comment "A submolecular entity is a chemical entity that is a part of a molecule." ;
  rdfs:subClassOf sio:ChemicalEntity .

sio:Submolecule a owl:Class ;
  rdfs:comment "A submolecule is any part of a molecule." ;
  rdfs:subClassOf sio:SubmolecularEntity .

sio:Substrate a owl:Class ;
  rdfs:comment """A substrate is a molecule that is consumed in the course of a biochemical reaction.
""" ;
  rdfs:subClassOf sio:Target .

sio:SubstrateRole a owl:Class ;
  rdfs:comment "The role of a chemical entity that is modified in a chemical reaction." ;
  rdfs:subClassOf sio:ReactantRole .

sio:Suffering a owl:Class ;
  rdfs:comment """Suffering is the unpleasant emotion and aversion associated with the perception of harm or threat of harm in an individual.
""" ;
  rdfs:subClassOf sio:Hurt .

sio:Suicidal a owl:Class ;
  rdfs:comment """suicidal is the emotion of being deeply unhappy or depressed with thoughts of killing one's self.
""" ;
  rdfs:subClassOf sio:NegativeEmotion .

sio:SulfurAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Sum a owl:Class ;
  rdfs:comment "A sum is the result of adding a set of values together." ;
  rdfs:subClassOf sio:Quantity .

sio:Supernatant a owl:Class ;
  rdfs:comment "A supernatent is a liquid substance that remains after centrifugation." ;
  rdfs:subClassOf sio:CentrifugationSubstance .

sio:SurfaceArea a owl:Class ;
  rdfs:comment """The surface area of a is a measure of the total area that the surface of the object occupies.
""" ;
  rdfs:subClassOf sio:Area .

sio:SurfaceNormal a owl:Class ;
  rdfs:comment "A surface normal is a vector that is perpendicular to a flat surface." ;
  rdfs:subClassOf sio:VectorLine .

sio:Surprise a owl:Class ;
  rdfs:comment "surprise is a brief emotion experienced as the result of an unexpected event. " ;
  rdfs:subClassOf sio:PositiveEmotion .

sio:Suspended a owl:Class ;
  rdfs:comment """suspended is the status of a process that is no longer progressing towards completion.
""" ;
  rdfs:subClassOf sio:ProcessStatus .

sio:Syllable a owl:Class ;
  rdfs:comment """A syllable is a verbal entity of language having one vowel sound, with or without surrounding consonants, forming the whole or a part of a word.
""" ;
  rdfs:subClassOf sio:VerbalLanguageEntity .

sio:Symbol a owl:Class ;
  rdfs:comment "A symbol is a proposition about what an entity represents." ;
  rdfs:subClassOf sio:Representation .

sio:SymportEnabledSecondaryActiveTransport a owl:Class ;
  rdfs:comment """symport enabled secondary active transport is a secondary active transfort in which both ion and molecule are transported in the same direction simultaneously.
""" ;
  rdfs:subClassOf sio:SecondaryActiveTransport .

sio:Syndrome a owl:Class ;
  rdfs:comment """A syndrome is composed of a set of several clinically recognizable features, signs (observed by someone other than the patient), symptoms (reported by the patient), phenomena or characteristics that often occur together.
""" ;
  rdfs:subClassOf sio:Description .

sio:Synonym a owl:Class ;
  rdfs:comment "A synonym is a word with the same or very similar meanings." ;
  rdfs:subClassOf sio:TermVariant .

sio:SynthesisReaction a owl:Class ;
  rdfs:comment """A synthesis reaction is an inorganic reaction in which two or more molecules are chemically bonded together to produce a single product.
""" ;
  rdfs:subClassOf sio:InorganicReaction .

sio:SyntheticQuality a owl:Class ;
  rdfs:comment """synthetic quality is the quality of a manufactured object that has similar properties as naturally occuring objects.
""" ;
  rdfs:subClassOf sio:ObjectRelationalQuality .

sio:TStatistic a owl:Class ;
  rdfs:comment """A t-statistic is a ratio of the departure of an estimated parameter from its notional value and its standard error. 
""" ;
  rdfs:subClassOf sio:Ratio .

sio:TStatisticBasedDecreasedDifferentialGeneExpression a owl:Class ;
  rdfs:comment """A t-statistic based decreased differential gene expression is a differential gene expression ratio in which the t-statistic is less than zero.
""" ;
  rdfs:subClassOf sio:DifferentialGeneExpressionRatio .

sio:TStatisticBasedIncreasedDifferentialGeneExpression a owl:Class ;
  rdfs:comment """A t-statistic based increased differential gene expression is a differential gene expression ratio in which the t-statistic is greater than zero.
""" ;
  rdfs:subClassOf sio:DifferentialGeneExpressionRatio .

sio:Table a owl:Class ;
  rdfs:comment "A table is a figure that consists of an ordered arrangement of columns and rows." ;
  rdfs:subClassOf sio:Figure .

sio:TableOfContents a owl:Class ;
  rdfs:comment """The table of contents is a document section that lists all sections (and optionally subsections) in a sequential order along with their page number.
""" ;
  rdfs:subClassOf sio:DocumentSection .

sio:TagCloud a owl:Class ;
  rdfs:comment "A tag cloud is a visualization of word frequencies." ;
  rdfs:subClassOf sio:TextualChart .

sio:TantalumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Target a owl:Class ;
  rdfs:comment "None" .

sio:TechnetiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:TechnicalReport a owl:Class ;
  rdfs:comment """A technical report is a publication published by a school or other institution, usually numbered within a series.
""" ;
  rdfs:subClassOf sio:Publication .

sio:Telephone a owl:Class ;
  rdfs:comment """The telephone is a communications device that transmits and receives sounds, and are minimally composed of a microphone to speak into, a speaker'which reproduces the voice of the other person and a ringer which makes a sound to alert the owner when a call is coming in.
""" ;
  rdfs:subClassOf sio:CommunicationDevice .

sio:TelephoneNumber a owl:Class ;
  rdfs:comment """a telephone number is an identifier used to connect to a physical device capable of transfering voice or data over a network.
""" ;
  rdfs:subClassOf sio:InformationalEntityIdentifier .

sio:TelevisionProgram a owl:Class ;
  rdfs:comment """A television program is a audiovisual media that is produced and broadcast using a television.
""" ;
  rdfs:subClassOf sio:Media .

sio:TelluriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:TemporalQualifier a owl:Class ;
  rdfs:comment "a temporal qualifier is pertains to the frequency of the event of interest." ;
  rdfs:subClassOf sio:InformationalQuality .

sio:Tensor a owl:Class ;
  rdfs:comment "a tensor is a n-dimensional array." ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:TerbiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Term a owl:Class ;
  rdfs:comment "A term is a word or phrase used to denote one or more entities." ;
  rdfs:subClassOf sio:LanguageEntity , [
    a owl:Restriction ;
    owl:onProperty sio:is_narrower_thant ;
    owl:allValuesFrom sio:Term
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_narrower_thant ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_match_to ;
    owl:allValuesFrom sio:Term
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_match_to ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_broader_thant ;
    owl:allValuesFrom sio:Term
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_broader_thant ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:TermVariant a owl:Class ;
  rdfs:comment "A term variant is a term that is a variant of another term." ;
  rdfs:subClassOf sio:Term .

sio:TerminalPoint a owl:Class ;
  rdfs:comment "A terminal point is a point that defines the finite extension of a line." ;
  rdfs:subClassOf sio:Point .

sio:Terminology a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Vocabulary .

sio:Territory a owl:Class ;
  rdfs:comment "A territory is a non-sovereign geographic region." ;
  rdfs:subClassOf sio:GeopoliticalRegion .

sio:Terror a owl:Class ;
  rdfs:comment "terror is the extreme feeling of fear." ;
  rdfs:subClassOf sio:Dread .

sio:TertiaryStructureDescriptor a owl:Class ;
  rdfs:comment """A tertiary structure descriptor describes 3D topological patterns in a biopolymer.
""" ;
  rdfs:subClassOf sio:BiomolecularStructureDescriptor .

sio:TestRole a owl:Class ;
  rdfs:comment """A test role is the role of an individual that is a participant in the study and is the target of the intervention.
""" ;
  rdfs:subClassOf sio:EvaluationRole .

sio:TextQuality a owl:Class ;
  rdfs:comment "text quality is the quality of a textual entity." ;
  rdfs:subClassOf sio:ObjectQuality .

sio:TextSpan a owl:Class ;
  rdfs:comment """A text span is a subset of contiguous sequence of characters of a textual entity.
""" ;
  rdfs:subClassOf sio:TextualEntity .

sio:TextSpanEndPosition a owl:Class ;
  rdfs:comment """text span end position is the position (offset) of the last character of a text span in relation the text it is from.
""" ;
  rdfs:subClassOf sio:EndPosition .

sio:TextSpanStartPosition a owl:Class ;
  rdfs:comment """text span start position is the position (offset) of the first character of a text span in relation the text it is from.
""" ;
  rdfs:subClassOf sio:StartPosition .

sio:TextualChart a owl:Class ;
  rdfs:comment "A textual chart is a chart containing text." ;
  rdfs:subClassOf sio:Chart .

sio:TextualEntity a owl:Class ;
  rdfs:comment """A textual entity is language entity that is manifested as a sequence of one or more distinct characters.
""" ;
  rdfs:subClassOf sio:LanguageEntity .

sio:ThalliumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:TherapeuticGeneDiseaseAssociation a owl:Class ;
  rdfs:comment """A gene disease association in which the gene is a therapeutic marker for the disease.
""" ;
  rdfs:subClassOf sio:GeneDiseaseAssociation .

sio:ThesisDocument a owl:Class ;
  rdfs:comment """A thesis document is the written research component of a post-secondary institution  that contains a statement supported by arguments.
""" ;
  rdfs:subClassOf sio:Publication .

sio:Thickness a owl:Class ;
  rdfs:comment "thickness is the shortest dimensional extent of a 3D projection of an object." ;
  rdfs:subClassOf sio:Depth .

sio:ThoriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:ThuliumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:TickMark a owl:Class ;
  rdfs:comment """A tick mark is a line segment that is spatially positioned perpendicular to the axis of a statistical graph and indicates the position of a specific numeric value (which may be indicated by an adjacent value label) on a value axis, or is one of a pair of tick marks that delineates the boundary of a categorical value (which may be indicated by an adjacent category label) on the categorical axis.
""" ;
  rdfs:subClassOf sio:LineSegment .

sio:TimeInstant a owl:Class ;
  rdfs:comment """A time instant is a temporal region which occurs instantaneously, e.g. having no duration.
""" ;
  rdfs:subClassOf sio:TimeMeasurement , [
    a owl:Restriction ;
    owl:onProperty sio:is_start_time_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_start_time_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_time_boundary_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_time_boundary_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_end_time_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_end_time_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:TimeInterval a owl:Class ;
  rdfs:comment "A time internval is a contiguous temporal region having some duration." ;
  rdfs:subClassOf sio:TimeMeasurement .

sio:TimeMeasurement a owl:Class ;
  rdfs:comment """time measurement is a measurement value of the duration of some interval of time or a particular instant of time (against some frame of reference).
""" ;
  rdfs:subClassOf sio:DimensionalQuantity .

sio:TinAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Tissue a owl:Class ;
  rdfs:comment """A tissue is a mereologically maximal collection of cells that together perform some function.
""" ;
  rdfs:subClassOf sio:BiologicalEntity .

sio:TitaniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Title a owl:Class ;
  rdfs:comment "A title is a textual entity that summarily describes some entity." ;
  rdfs:subClassOf sio:Label .

sio:ToActivelyInteractWith a owl:Class ;
  rdfs:comment """to actively interact with is the capability to interact with another entity in a way that requires physical contact.
""" ;
  rdfs:subClassOf sio:ToInteractWith .

sio:ToAddACovalentBond a owl:Class ;
  rdfs:comment """to add a covalent bond is the capability to covalently modify a chemical entity by adding a covalent bond.
""" ;
  rdfs:subClassOf sio:ToCovalentlyModify .

sio:ToAssemble a owl:Class ;
  rdfs:comment """to assemble is the capability to combine entities together into a larger object that persists in time.
""" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToAssociate a owl:Class ;
  rdfs:comment "to associate is the capability to physically interact with another object." ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToBeAMemberOf a owl:Class ;
  rdfs:comment "to be a member of is the capability to be considered a part of a collection." ;
  rdfs:subClassOf sio:ToPassivelyInteractWith .

sio:ToBeAPartOf a owl:Class ;
  rdfs:comment """to be a part of is the capability to be assembled into a larger structure that persists in time.
""" ;
  rdfs:subClassOf sio:ToBeCombined .

sio:ToBeActivated a owl:Class ;
  rdfs:comment """to be activated is the capability to be modified in such a way that the conformational change leads to an increase in another capability.
""" ;
  rdfs:subClassOf sio:ToBeConformationallyChanged .

sio:ToBeActivelyInteractedWith a owl:Class ;
  rdfs:comment """to be actively interacted with is the capability to be manipulated by some device or agent.
""" ;
  rdfs:subClassOf sio:ToBeInteractedWith .

sio:ToBeCleaved a owl:Class ;
  rdfs:comment """to be cleaved is the capability to be modified in a way that splits one part of the object from the other.
""" ;
  rdfs:subClassOf sio:ToBeModified .

sio:ToBeCombined a owl:Class ;
  rdfs:comment """to be combined is the capability to be modified in a way that the object is merged with another object to form a new object or substance.
""" ;
  rdfs:subClassOf sio:ToBeModified .

sio:ToBeCompared a owl:Class ;
  rdfs:comment """to be compared is the capability of an object to be examined in order to note the similarities or differences among a set of objects.
""" ;
  rdfs:subClassOf sio:ToBeExamined .

sio:ToBeConformationallyChanged a owl:Class ;
  rdfs:comment """to be conformationally changed is the capability to be modified in such a way that the object's conformation is changed.
""" ;
  rdfs:subClassOf sio:ToBeModified .

sio:ToBeCovalentlyModified a owl:Class ;
  rdfs:comment """to be covalently modified is the capability of a chemical entity to have bonds added or removed
""" ;
  rdfs:subClassOf sio:ToBeModified .

sio:ToBeElectronicallyModified a owl:Class ;
  rdfs:comment """to be electronically modified is the capability of a chemical entity to have electrons added or removed.
""" ;
  rdfs:subClassOf sio:ToBeModified .

sio:ToBeExamined a owl:Class ;
  rdfs:comment """to be examined is the capability of an object to be observed in a detailed manner.
""" ;
  rdfs:subClassOf sio:ToBeObserved .

sio:ToBeInhibited a owl:Class ;
  rdfs:comment """to be inhibited is the capability to be modified in such a way that the conformational change leads to an decrease in another capability.
""" ;
  rdfs:subClassOf sio:ToBeConformationallyChanged .

sio:ToBeInteractedWith a owl:Class ;
  rdfs:comment """to be interacted with is the capability of an object to be target of a physical interaction.
""" ;
  rdfs:subClassOf sio:Capability .

sio:ToBeModified a owl:Class ;
  rdfs:comment """to be modified is the capability to be actively interacted with in such a way that it leads to a physical reconfiguration.
""" ;
  rdfs:subClassOf sio:ToBeActivelyInteractedWith .

sio:ToBeObserved a owl:Class ;
  rdfs:comment "to be observed is the capability of an object to be perceived." ;
  rdfs:subClassOf sio:ToBePassivelyInteractedWith .

sio:ToBePassivelyInteractedWith a owl:Class ;
  rdfs:comment "to be passively interacted with is the capability of an object to be observed." ;
  rdfs:subClassOf sio:ToBeInteractedWith .

sio:ToBeRecorded a owl:Class ;
  rdfs:comment """to be recorded is the capability of an object to be observed in such a way that information about it can be transcribed in a specified format on some physical medium.
""" ;
  rdfs:subClassOf sio:ToBeObserved .

sio:ToBeTranslocated a owl:Class ;
  rdfs:comment """to be translocated is the capability to be physically displaced from one location to another
""" ;
  rdfs:subClassOf sio:ToBeInteractedWith .

sio:ToBeTransported a owl:Class ;
  rdfs:comment "to be transported is the disposition to undergo motion." ;
  rdfs:subClassOf sio:ToBeActivelyInteractedWith .

sio:ToBindTo a owl:Class ;
  rdfs:comment """to bind to is the capability to physically interact with another object through a set of non-covalent interactions.
""" ;
  rdfs:subClassOf sio:ToAssociate .

sio:ToBoil a owl:Class ;
  rdfs:comment """to boil is the capability to increase the internal kinetic energy of a material such that it changes state from a solid or liquid to a gas.
""" ;
  rdfs:subClassOf sio:ToHeat .

sio:ToBreathe a owl:Class ;
  rdfs:comment """to breathe is the capability to inhale and exhale air into the body during respiration.
""" ;
  rdfs:subClassOf sio:Capability .

sio:ToCauseDisease a owl:Class ;
  rdfs:comment """to cause disease is the capability to materially change a biological object in that it functions abnormally.
""" ;
  rdfs:subClassOf sio:ToChangeMaterially .

sio:ToChangeAppearance a owl:Class ;
  rdfs:comment """to change appearance is the capability to change the visual attributes of an object.
""" ;
  rdfs:subClassOf sio:ToModify .

sio:ToChangeEnergetically a owl:Class ;
  rdfs:comment """to change energetically is the capability to change the energetic aspects of an object.
""" ;
  rdfs:subClassOf sio:ToModify .

sio:ToChangeMaterially a owl:Class ;
  rdfs:comment """to change appearance is the capability to change the material composition of an object.
""" ;
  rdfs:subClassOf sio:ToModify .

sio:ToChangeSpatially a owl:Class ;
  rdfs:comment """to change spatially is the capability to affect the physical movement of some entity.
""" ;
  rdfs:subClassOf sio:ToModify .

sio:ToChangeTheActivationEnergy a owl:Class ;
  rdfs:comment """to change the activation energy is to change the amount of energy required to form or break a chemical bond.
""" ;
  rdfs:subClassOf sio:ToChangeEnergetically .

sio:ToCharacterize a owl:Class ;
  rdfs:comment """to characterize is the capability to classify the attributes or features of an entity against a reference classification.
""" ;
  rdfs:subClassOf sio:ToDescribe .

sio:ToCleave a owl:Class ;
  rdfs:comment "to cleave is to split or sever an object along a natural line or grain." ;
  rdfs:subClassOf sio:ToDisassemble .

sio:ToCombine a owl:Class ;
  rdfs:comment """to combine is the capability to modify a set of objects in a way that the object is merged with another object to form a new object or substance.
""" ;
  rdfs:subClassOf sio:ToChangeMaterially .

sio:ToCompare a owl:Class ;
  rdfs:comment """to compare is the capability to examine in order to note the similarities or differences among a set of objects.
""" ;
  rdfs:subClassOf sio:ToExamine .

sio:ToConformationallyActivate a owl:Class ;
  rdfs:comment """to conformationally activate is to modify the conformation of an entity in such a way that it becomes activated or functional.
""" ;
  rdfs:subClassOf sio:ToModifyConformationOf .

sio:ToConformationallyInhibit a owl:Class ;
  rdfs:comment """to conformationally inhibit is to modify the conformation of an entity in such a way that it functionally is reduced or inhibited.
""" ;
  rdfs:subClassOf sio:ToModifyConformationOf .

sio:ToConsume a owl:Class ;
  rdfs:comment "to consume is the capability to internalize a material entity." ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToContain a owl:Class ;
  rdfs:comment """to contain is the capability to bound or constrain a physical entity in some site.
""" ;
  rdfs:subClassOf sio:ToChangeSpatially .

sio:ToCool a owl:Class ;
  rdfs:comment "to cool is the capability to decrease the internal kinetic energy of a material." ;
  rdfs:subClassOf sio:ToReduceEnergy .

sio:ToCovalentlyModify a owl:Class ;
  rdfs:comment """to covalently modify is to materially change a molecule by adding or removing covalent bonds between atoms.
""" ;
  rdfs:subClassOf sio:ToChangeMaterially .

sio:ToDecodeInformation a owl:Class ;
  rdfs:comment "the ability to reverse an encoding operation" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToDecreaseTheRateOfFormation a owl:Class ;
  rdfs:comment """to decrease the rate of formation is to regulate the rate of formation in a manner that decreases this rate relative to a reference process.
""" ;
  rdfs:subClassOf sio:ToRegulateTheRateOfFormation .

sio:ToDemagnify a owl:Class ;
  rdfs:comment """to demagnify is the capability to decrease the appearance of the size of an object.
""" ;
  rdfs:subClassOf sio:ToChangeAppearance .

sio:ToDescribe a owl:Class ;
  rdfs:comment "to describe is the capabilty to communicate facts about an entity." ;
  rdfs:subClassOf sio:ToPassivelyInteractWith .

sio:ToDisassemble a owl:Class ;
  rdfs:comment "to disassemble is to physically separate the parts of an object." ;
  rdfs:subClassOf sio:ToChangeMaterially .

sio:ToDisassociate a owl:Class ;
  rdfs:comment "to disassociate is to cease or break association with some thing." ;
  rdfs:subClassOf sio:ToModify .

sio:ToDistort a owl:Class ;
  rdfs:comment """to distort is the capability to change the appearance of an entity by some transformation.
""" ;
  rdfs:subClassOf sio:ToChangeAppearance .

sio:ToEmit a owl:Class ;
  rdfs:comment """to emit is the capability to release some physical entity (light, pollution, etc).
""" ;
  rdfs:subClassOf sio:ToReduceEnergy .

sio:ToEncodeInformation a owl:Class ;
  rdfs:comment "the capability to encode information in a different representation" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToExamine a owl:Class ;
  rdfs:comment "to examine is the capability to make detailed observation. " ;
  rdfs:subClassOf sio:ToObserve .

sio:ToExcite a owl:Class ;
  rdfs:comment """to excite is the capability to supply energy to a materila by bombarding it with energetic particles (e.g., photons).
""" ;
  rdfs:subClassOf sio:ToSupplyEnergy .

sio:ToExtract a owl:Class ;
  rdfs:comment """to extract is the capability to remove certain entities based on selected attribute(s) while allowing other entities to remain.
""" ;
  rdfs:subClassOf sio:ToSeparate .

sio:ToFilter a owl:Class ;
  rdfs:comment """to filter is the capability to retain certain entities based on selected attribute(s) while allowing other entities to pass through.
""" ;
  rdfs:subClassOf sio:ToSeparate .

sio:ToFluoresce a owl:Class ;
  rdfs:comment """to fluoresce is to emit light as a result of absorbing light or other electromagnetic radiation.
""" ;
  rdfs:subClassOf sio:ToLuminesce .

sio:ToFreeze a owl:Class ;
  rdfs:comment """to freeze is the capability to decrease the internal kinetic energy of a material such that it changes state from a gas or liquid to a solid.
""" ;
  rdfs:subClassOf sio:ToCool .

sio:ToGainACovalentBond a owl:Class ;
  rdfs:comment """to gain a covalent bond is the capability of a chemical entity to have bonds added.
""" ;
  rdfs:subClassOf sio:ToBeCovalentlyModified .

sio:ToGainAnElectron a owl:Class ;
  rdfs:comment """to gain an electron is the capability of a chemical entity to receive an electron.
""" ;
  rdfs:subClassOf sio:ToBeElectronicallyModified .

sio:ToHeat a owl:Class ;
  rdfs:comment "to heat is a capability to increase the internal kinetic energy of a material." ;
  rdfs:subClassOf sio:ToSupplyEnergy .

sio:ToIdentify a owl:Class ;
  rdfs:comment "to identify is the capability to determine the identity of something." ;
  rdfs:subClassOf sio:ToInvestigate .

sio:ToImmobilize a owl:Class ;
  rdfs:comment """to immobilize is the capability to contain an entity in such a way that it may not move in space.
""" ;
  rdfs:subClassOf sio:ToContain .

sio:ToIncreaseTheActivationEnergy a owl:Class ;
  rdfs:comment """to increase the activation energy is to require a larger amount of energy in order to form or break a chemical bond.
""" ;
  rdfs:subClassOf sio:ToChangeTheActivationEnergy .

sio:ToIncreaseTheRateOfFormation a owl:Class ;
  rdfs:comment """to increase the rate of formation is to regulate the rate of formation in a manner that increases this rate relative to a reference process.
""" ;
  rdfs:subClassOf sio:ToRegulateTheRateOfFormation .

sio:ToInfect a owl:Class ;
  rdfs:comment """to infect is the capability to administer a disease-causing organism into some object.
""" ;
  rdfs:subClassOf sio:ToInject .

sio:ToIngest a owl:Class ;
  rdfs:comment """to ingest is the capability to take into the body by the mouth for digestion or absorption.
""" ;
  rdfs:subClassOf sio:ToConsume .

sio:ToInject a owl:Class ;
  rdfs:comment """to inject is the capability to administer a substance into some object through its external barrier.
""" ;
  rdfs:subClassOf sio:ToModify .

sio:ToInteractAndToBeInteractedWith a owl:Class ;
  rdfs:comment """to interact and to be interacted with is a mutual disposition of interacting objects.
""" ;
  rdfs:subClassOf sio:MutualDisposition .

sio:ToInteractWith a owl:Class ;
  rdfs:comment "to interact with is a capabililty that involves another object." ;
  rdfs:subClassOf sio:Capability .

sio:ToInvestigate a owl:Class ;
  rdfs:comment "to investigate is the capability to uncover facts." ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToIonize a owl:Class ;
  rdfs:comment """to ionize is the capability to physically convert an atom or molecule into an ion by adding or removing charged particles such as electrons or other ions.
""" ;
  rdfs:subClassOf sio:ToModifyElectronically .

sio:ToLoseACovalentBond a owl:Class ;
  rdfs:comment """to lose a covalent bond is the capability of a chemical entity to have bonds removed.
""" ;
  rdfs:subClassOf sio:ToBeCovalentlyModified .

sio:ToLoseAnElectron a owl:Class ;
  rdfs:comment "to lose an electron is the capability of a chemical entity to lose an electron." ;
  rdfs:subClassOf sio:ToBeElectronicallyModified .

sio:ToLuminesce a owl:Class ;
  rdfs:comment "to luminesce is to emit light through cold body radiation" ;
  rdfs:subClassOf sio:ToBeActivelyInteractedWith .

sio:ToMagnify a owl:Class ;
  rdfs:comment """to magnify is the capability to increase the appearance of the size of an object.
""" ;
  rdfs:subClassOf sio:ToChangeAppearance .

sio:ToMaintainInformation a owl:Class ;
  rdfs:comment """the capability to maintain information such that it can be retrieved in the future.
""" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToMeasure a owl:Class ;
  rdfs:comment """to measure is the capability to obtain information about some entity by examining its attributes in relation to some reference metric.
""" ;
  rdfs:subClassOf sio:ToInvestigate .

sio:ToModify a owl:Class ;
  rdfs:comment "to modify is the capability to change some entity." ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToModifyConformationOf a owl:Class ;
  rdfs:comment "to modify conformation of is to affect the spatial arrangement of an entity." ;
  rdfs:subClassOf sio:ToModify .

sio:ToModifyElectronically a owl:Class ;
  rdfs:comment """to modify electronically is the capability to change the electronic properties of an object.
""" ;
  rdfs:subClassOf sio:ToChangeEnergetically .

sio:ToModifyOxidationStateOf a owl:Class ;
  rdfs:comment """to modify the oxidation state of is to change the number of electrons of a molecule, atom or ion.
""" ;
  rdfs:subClassOf sio:ToModifyElectronically .

sio:ToNegativelyCharge a owl:Class ;
  rdfs:comment """to negatively charge is the capability to add an electron or negatively charged ion to a chemical entity.
""" ;
  rdfs:subClassOf sio:ToIonize .

sio:ToObserve a owl:Class ;
  rdfs:comment "to observe is the capability to watch attentively." ;
  rdfs:subClassOf sio:ToPassivelyInteractWith .

sio:ToOxidize a owl:Class ;
  rdfs:comment """to oxidize is the capability to remove an electron or an increase in oxidation state of a chemical entity.
""" ;
  rdfs:subClassOf sio:ToModifyOxidationStateOf .

sio:ToPassivelyInteractWith a owl:Class ;
  rdfs:comment """to passively interact with is the capability to interact with another entity in a way that does not require physical contact.
""" ;
  rdfs:subClassOf sio:ToInteractWith .

sio:ToPositivelyCharge a owl:Class ;
  rdfs:comment """to positively charge is the capability to remove an electron or add a  positively charged ion to a chemical entity.
""" ;
  rdfs:subClassOf sio:ToIonize .

sio:ToProduce a owl:Class ;
  rdfs:comment "to produce is the capability to create new objects" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToProvide a owl:Class ;
  rdfs:comment """to provide is the capability to make available some object to another that requires it.
""" ;
  rdfs:subClassOf sio:ToRetrieve .

sio:ToRecord a owl:Class ;
  rdfs:comment """to record is the capability to detect and transcribe information in a specified format on some physical medium.
""" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToReduce a owl:Class ;
  rdfs:comment """to reduce is the capability to add an electron or an decrease in oxidation state of a chemical entity.
""" ;
  rdfs:subClassOf sio:ToModifyOxidationStateOf .

sio:ToReduceEnergy a owl:Class ;
  rdfs:comment "to reduce energy is the capability to remove energy from a source." ;
  rdfs:subClassOf sio:ToChangeEnergetically .

sio:ToReduceTheActivationEnergy a owl:Class ;
  rdfs:comment """to reduce the activation energy is to require a smaller amount of energy in order to form or break a chemical bond.
""" ;
  rdfs:subClassOf sio:ToChangeTheActivationEnergy .

sio:ToRegulate a owl:Class ;
  rdfs:comment "to regulate is to control or maintain the rate or speed of an object or process." ;
  rdfs:subClassOf sio:ToModify .

sio:ToRegulateTheRateOfFormation a owl:Class ;
  rdfs:comment """to regulate the rate of formation is to modify the rate at which an object is formed.
""" ;
  rdfs:subClassOf sio:ToRegulate .

sio:ToRemoveACovalentBond a owl:Class ;
  rdfs:comment """to remove a covalent bond is the capability to covalently modify a chemical entity by removing a covalent bond.
""" ;
  rdfs:subClassOf sio:ToCovalentlyModify .

sio:ToRetrieve a owl:Class ;
  rdfs:comment "the capability to retrieve a (digitial/physical/mental) object from a location." ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToSeparate a owl:Class ;
  rdfs:comment """to separate is the capability to i) distinguish some entities based on some attribute(s) and ii) subsequently physically displace them.
""" ;
  rdfs:subClassOf sio:ToModify .

sio:ToServeAs a owl:Class ;
  rdfs:comment "to serve as is the capability to act in a manner corresponding to some role." ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToServeAsAHost a owl:Class ;
  rdfs:comment """to serve as host is the capability to act in a manner that provides hospitality, serves to harbour an organism in or on itself.
""" ;
  rdfs:subClassOf sio:ToServeAs .

sio:ToServeAsAPrimerForDnaSynthesis a owl:Class ;
  rdfs:comment """to serve as a primer for DNA synthesis is the capability of a short nucleic acid to bind to the 5' end of single strand of DNA template and help initiate DNA replication.
""" ;
  rdfs:subClassOf sio:ToServeAs .

sio:ToServeAsATemplateForDnaSynthesis a owl:Class ;
  rdfs:comment """to serve as a template for DNA synthesis is the capability of a chemical entity to provide the necessary information or scaffold by which a DNA molecule may be produced.
""" ;
  rdfs:subClassOf sio:ToServeAsATemplateForMolecularSynthesis .

sio:ToServeAsATemplateForMolecularSynthesis a owl:Class ;
  rdfs:comment """to serve as a template for molecular synthesis is the capability of a chemical entity to provide the necessary information or scaffold by which another molecule may be produced.
""" ;
  rdfs:subClassOf sio:ToServeAs .

sio:ToServeAsATemplateForProteinSynthesis a owl:Class ;
  rdfs:comment """to serve as a template for protein synthesis is the capability of a chemical entity to provide the necessary information or scaffold by which a protein may be produced.
""" ;
  rdfs:subClassOf sio:ToServeAsATemplateForMolecularSynthesis .

sio:ToServeAsATemplateForRnaSynthesis a owl:Class ;
  rdfs:comment """to serve as a template for RNA synthesis is the capability of a chemical entity to provide the necessary information or scaffold by which an RNA molecule may be produced.
""" ;
  rdfs:subClassOf sio:ToServeAsATemplateForMolecularSynthesis .

sio:ToStore a owl:Class ;
  rdfs:comment """to store is the capability to place an object into a medium in which it can be retrieved in the future.
""" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:ToSupplyElectricity a owl:Class ;
  rdfs:comment """to supply electricity is the capability to transfer electricity from a source to a sink.
""" ;
  rdfs:subClassOf sio:ToSupplyEnergy .

sio:ToSupplyEnergy a owl:Class ;
  rdfs:comment "to supply energy is the capability to transfer energy from a source to a sink." ;
  rdfs:subClassOf sio:ToChangeEnergetically .

sio:ToTestAHypothesis a owl:Class ;
  rdfs:comment """to test a hypothesis is the capability to evaluate the truth value of a proposition based on gathered evidence.
""" ;
  rdfs:subClassOf sio:ToExamine .

sio:ToTranslocate a owl:Class ;
  rdfs:comment """to translocate is the capability to displace oneself from one location to another.
""" ;
  rdfs:subClassOf sio:ToInteractWith .

sio:ToTransport a owl:Class ;
  rdfs:comment """to transport is the capability to displace a material from one location to another.
""" ;
  rdfs:subClassOf sio:ToActivelyInteractWith .

sio:TopValueAxis a owl:Class ;
  rdfs:comment """A top value axis is a value axis that is spatially positioned to the top of the plot area.
""" ;
  rdfs:subClassOf sio:ValueAxis .

sio:Township a owl:Class ;
  rdfs:comment "A township is a rural or sub-urban settlement." ;
  rdfs:subClassOf sio:GeopoliticalRegion .

sio:Toxic a owl:Class ;
  rdfs:comment """toxic is the quality of a substance imparing the normal functioning of a  system.
""" ;
  rdfs:subClassOf sio:Toxicity .

sio:ToxicRole a owl:Class ;
  rdfs:comment "A toxic role is the role of a chemical substance that is poisonous." ;
  rdfs:subClassOf sio:ChemicalSubstanceRole .

sio:Toxicity a owl:Class ;
  rdfs:comment """toxicity is the quality of a chemical substance to cause injury to an organism in a dose dependent manner.
""" ;
  rdfs:subClassOf sio:ChemicalQuality .

sio:ToxinRole a owl:Class ;
  rdfs:comment """A toxin role is a toxic role of a chemical substance that is poisonous and is produced by an organism.
""" ;
  rdfs:subClassOf sio:PoisonRole .

sio:TransRegulatoryElement a owl:Class ;
  rdfs:comment """A trans-regulatory element is a DNA sequence associated with the regulation of a gene located outside the genomic region supporting the corresponding structural DNA region of the trans-regulatory element (i.e., a different DNA strand or different chromosome).
""" ;
  rdfs:subClassOf sio:NucleicAcidPart .

sio:Transcription a owl:Class ;
  rdfs:comment """transcription is the process of creating a complementary RNA copy of a sequence of DNA.
""" ;
  rdfs:subClassOf sio:Biosynthesis .

sio:TransferRnAtRna a owl:Class ;
  rdfs:comment """A transfer RNA (tRNA) is an RNA molecule that aids in the translation of a messenger RNA (mRNA) to produce a protein product.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRna .

sio:TransferRnAtRnaGene a owl:Class ;
  rdfs:comment """A transfer RNA (tRNA) gene is a gene that codes for a tRNA used in the translation of a messenger RNA (mRNA) to produce a protein product.
""" ;
  rdfs:subClassOf sio:NonProteinCodingRnAncRnaGene .

sio:Translation a owl:Class ;
  rdfs:comment """translation is the process of producing a polypeptide from a ribonucleic acid by a ribosome.
""" ;
  rdfs:subClassOf sio:Biosynthesis .

sio:Transporting a owl:Class ;
  rdfs:comment """transporting is a  process in which one object physically moves another object from one location to another.
""" ;
  rdfs:subClassOf sio:Interacting .

sio:TreeDiagram a owl:Class ;
  rdfs:comment """A tree diagram is a hierarchical network diagram in which a root vertex is connected to one or more other vertices through a directed edge, which in turn may be connected to other vertices.
""" ;
  rdfs:subClassOf sio:DirectedAcyclicGraph .

sio:Treemap a owl:Class ;
  rdfs:comment """A treemap is a chart that fully partitions the area into a set of rectangles whose area represents its relative value.
""" ;
  rdfs:subClassOf sio:MereologicalChart .

sio:TrendLine a owl:Class ;
  rdfs:comment """A trend line is a line, line segment or ray that is part of a statistical graph which indicates a statistical or visual direction across categorical or value data.
""" ;
  rdfs:subClassOf sio:StatisticalGraphLine .

sio:Triangle a owl:Class ;
  rdfs:comment """A triangle is a polygon composed of three points and three line segments, in which each point is fully connected to another point along through the line segment.
""" ;
  rdfs:subClassOf sio:Polygon .

sio:TripleBond a owl:Class ;
  rdfs:comment """A triple bond is a covalent bond between a pair of atoms in which three pairs of electrons are shared.
""" ;
  rdfs:subClassOf sio:CovalentBond .

sio:True a owl:Class ;
  rdfs:comment "true is a truth value that indicates that it holds under all possible worlds." ;
  rdfs:subClassOf sio:TruthValue .

sio:TruthValue a owl:Class ;
  rdfs:comment """truth value is a quality of information that is claimed/verified to be true or false.
""" ;
  rdfs:subClassOf sio:InformationalQuality .

sio:TungstenAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Url a owl:Class ;
  rdfs:comment """A Uniform Resource Locator or Universal Resource Locator (URL) is a specific character string that constitutes a reference to an Internet resource.
""" ;
  rdfs:subClassOf sio:InformationalEntityIdentifier .

sio:UncertaintyValue a owl:Class ;
  rdfs:comment """The uncertainty value (margin of error) of a measurement is a range of values likely to enclose the true value. 
""" ;
  rdfs:subClassOf sio:Quantity .

sio:Uncharged a owl:Class ;
  rdfs:comment "The quality of not having a charge." ;
  rdfs:subClassOf sio:ChargeQuality .

sio:UndergraduateStudentAdvisorRole a owl:Class ;
  rdfs:comment """An undergraduate student advisor role is the role of an individual employed at an academic organization that is involved in advising undergraduate students.
""" ;
  rdfs:subClassOf sio:StudentAdvisorRole .

sio:UnicellularOrganism a owl:Class ;
  rdfs:comment "A unicellular organism is a organism that is composed of a single cell." ;
  rdfs:seeAlso sio:CellularOrganism ;
  rdfs:subClassOf sio:Cell .

sio:UnigeneCluster a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Collection .

sio:Union a owl:Class ;
  rdfs:comment """A union is a list of all of the values of an attribute for the entities in the defined set.
""" ;
  rdfs:subClassOf sio:List .

sio:UniqueCell a owl:Class ;
  rdfs:comment "A unique cell is a cell that contains a unique value in the cellular automaton." ;
  rdfs:subClassOf sio:Cellinformational .

sio:UniqueIdentifier a owl:Class ;
  rdfs:comment "A unique identifier is an identifier that uniquely identifies some thing." ;
  rdfs:subClassOf sio:Identifier , [
    a owl:Restriction ;
    owl:onProperty sio:is_unique_identifier_for ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_unique_identifier_for ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:UnitOfMeasurement a owl:Class ;
  rdfs:comment """A unit of measurement is a definite magnitude of a physical quantity, defined and adopted by convention and/or by law, that is used as a standard for measurement of the same physical quantity.
""" ;
  rdfs:subClassOf sio:Quantity , [
    a owl:Restriction ;
    owl:onProperty sio:is_unit_of ;
    owl:allValuesFrom sio:Entity
  ] , [
    a owl:Restriction ;
    owl:onProperty sio:is_unit_of ;
    owl:maxCardinality "1"^^xsd:nonNegativeInteger
  ] .

sio:University a owl:Class ;
  rdfs:comment """A university is an institution of higher education and research which grants academic degrees in a variety of subjects and provides both undergraduate education and postgraduate education. 
""" ;
  rdfs:subClassOf sio:AcademicOrganization .

sio:Unsupported a owl:Class ;
  rdfs:comment """unsupported is an existence quality in which there is no evidence to support the existence of the entity in any world (real or hypothetical)
""" ;
  rdfs:subClassOf sio:ExistenceQuality .

sio:UnunhexiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:UnunoctiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:UnunpentiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:UnunquadiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:UnunseptiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:UnutriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:UraniumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:UserAccount a owl:Class ;
  rdfs:comment """user account allows a user to authenticate to system services and be granted authorization to access them.
""" ;
  rdfs:subClassOf sio:ComputationalEntity .

sio:ValidArgument a owl:Class ;
  rdfs:comment """A valid argument is an argument where the truth of the conclusion is a logical consequence of the premises and (consequently) its corresponding conditional is a necessary truth.
""" ;
  rdfs:subClassOf sio:Argument .

sio:ValidatedGene a owl:Class ;
  rdfs:comment """An experimentally validated gene is a gene whose existence has been demonstrated through experimental methods.
""" ;
  rdfs:subClassOf sio:Gene .

sio:ValueAxis a owl:Class ;
  rdfs:comment """A value axis is an axis in which the position along the line is partioned into numeric values.
""" ;
  rdfs:subClassOf sio:Axis .

sio:VanDerWaalsInteraction a owl:Class ;
  rdfs:comment """van der Waals' interaction is an a weak submolecular interaction between an instantaneous dipole and induced dipole.
""" ;
  rdfs:subClassOf sio:WeakSubmolecularComponent .

sio:VanadiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Variable a owl:Class ;
  rdfs:comment """A variable is a value that may change within the scope of a given problem or set of operations.
""" ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:VariantRole a owl:Class ;
  rdfs:comment """A variant role is a comparative role in which the value of an attribute differs when compared to another entity
""" ;
  rdfs:subClassOf sio:ComparativeRole .

sio:Vector a owl:Class ;
  rdfs:comment "a vector is a rank 1 tensor that is described by n-dimension of scalars." ;
  rdfs:subClassOf sio:RankNonzeroTensor .

sio:VectorLine a owl:Class ;
  rdfs:comment """A vector line is a line which that is bounded by a startpoint and extends outwards along one dimension.
""" ;
  rdfs:subClassOf sio:Ray .

sio:VectorSpace a owl:Class ;
  rdfs:comment "a vector space is a set of vectors." ;
  rdfs:subClassOf sio:MathematicalEntity .

sio:Velocity a owl:Class ;
  rdfs:comment "The rate of change of an object's position and the direction of that change" ;
  rdfs:subClassOf sio:Speed .

sio:VennDiagram a owl:Class ;
  rdfs:comment """A Venn diagram is a chart that illustrates all possible logical relations between a finite collection of sets as overlapping circles.
""" ;
  rdfs:subClassOf sio:Chart .

sio:VerbalLanguage a owl:Class ;
  rdfs:comment "A verbal language is a language that uses sounds to communicate." ;
  rdfs:subClassOf sio:Language .

sio:VerbalLanguageEntity a owl:Class ;
  rdfs:comment "A verbal language entity is a language entity that is manifested through sound." ;
  rdfs:subClassOf sio:LanguageEntity .

sio:VersionLabel a owl:Class ;
  rdfs:comment """A version label is a label for a particular form or variation of an earlier or original type.
""" ;
  rdfs:subClassOf sio:Identifier .

sio:VersionedDataset a owl:Class ;
  rdfs:comment """a versioned dataset is a dataset with a particular release date or release number.
""" ;
  rdfs:subClassOf sio:Dataset .

sio:VersionedRecord a owl:Class ;
  rdfs:comment """A versioned record is a record for which there exists another variant based that was derived via modification of the facts.
""" ;
  rdfs:subClassOf sio:Record .

sio:VertexNormal a owl:Class ;
  rdfs:comment """A vertext normal is the normalized average of the surface normals of the faces that contain that vertex.
""" ;
  rdfs:subClassOf sio:VectorLine .

sio:VerticalBarGraph a owl:Class ;
  rdfs:comment """A vertical bar graph is a bar graph in which the rectangular bars are vertically oriented in space.
""" ;
  rdfs:subClassOf sio:BarGraph .

sio:VerticalLine a owl:Class ;
  rdfs:comment """A vertical line is a line that is positionally oriented perpendicular to the horizon.
""" ;
  rdfs:subClassOf sio:PositionallyOrientedLine .

sio:VeryDissatisfiedQualifier a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:SatisfactionQualifier .

sio:VeryGoodQuality a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QualityDescriptor .

sio:VeryPoorQuality a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:QualityDescriptor .

sio:Viroid a owl:Class ;
  rdfs:comment """A viroid is a molecule of RNA that does not code for and is not protected by a protein coat.
""" ;
  rdfs:subClassOf sio:NonCellularOrganism .

sio:Virtual a owl:Class ;
  rdfs:comment """virtual is the quality of an entity that exists only in a virtual setting such as a simulation or game environment.
""" ;
  rdfs:subClassOf sio:ExistenceQuality .

sio:Virus a owl:Class ;
  rdfs:comment """A virus is a non-cellular organism that can replicate only inside the living cells of an organism.
""" ;
  rdfs:subClassOf sio:NonCellularOrganism .

sio:VisualLanguageEntity a owl:Class ;
  rdfs:comment """A visual language entity is a language entity that is manifested within the spectrum of light and can be pereceived and processed by a visual system.
""" ;
  rdfs:subClassOf sio:LanguageEntity .

sio:Vocabulary a owl:Class ;
  rdfs:comment "A vocabulary is a collection of terms." ;
  rdfs:seeAlso sio:FunctionalSpecification ;
  rdfs:subClassOf sio:FormalSpecification .

sio:Volume a owl:Class ;
  rdfs:comment """volume is the quantity of three-dimensional space enclosed by some closed boundary.
""" ;
  rdfs:subClassOf sio:3DExtentQuantity .

sio:VolumeNumber a owl:Class ;
  rdfs:comment "volume number is a count of a sequence of periodicals." ;
  rdfs:subClassOf sio:Count .

sio:Vowel a owl:Class ;
  rdfs:comment """A vowel is a verbal entity of language that is pronounced with an open vocal tract so that there is no build-up of air pressure at any point above the glottis.
""" ;
  rdfs:subClassOf sio:VerbalLanguageEntity .

sio:Wave a owl:Class ;
  rdfs:comment """A wave is a physical entity that travels through space and time, consist of oscillations or vibrations and may be accompanied by the transfer of energy.
""" ;
  rdfs:subClassOf sio:HeterogeneousSubstance .

sio:Weak a owl:Class ;
  rdfs:comment """weak is a qualitative intensity value that is more intense than none, but less intense than mild.
""" ;
  rdfs:subClassOf sio:Intensity .

sio:WeakChemicalSalt a owl:Class ;
  rdfs:comment "a weak chemical salt is a chemical salt composed of weak eletrolytes." ;
  rdfs:subClassOf sio:ChemicalSalt .

sio:WeakSubmolecularComponent a owl:Class ;
  rdfs:comment """A weak submolecular component is a submolecular component that weakly connects submolecular components.
""" ;
  rdfs:subClassOf sio:SubmolecularEntity .

sio:WebPage a owl:Class ;
  rdfs:comment """A web page is a document that is published according to World Wide Web standards.
""" ;
  rdfs:subClassOf sio:Document .

sio:WebService a owl:Class ;
  rdfs:comment """A web service is a software application that can be accessed over a network, such as the Internet, and executed on a remote system hosting the requested services.
""" ;
  rdfs:subClassOf sio:SoftwareApplication .

sio:WebServiceInvocation a owl:Class ;
  rdfs:comment "A web service invocation involves the execution of a web service." ;
  rdfs:subClassOf sio:SofwareExecution .

sio:Website a owl:Class ;
  rdfs:comment "A website is a collection of documents published on the World Wide Web." ;
  rdfs:subClassOf sio:CollectionOfDocuments .

sio:Week a owl:Class ;
  rdfs:comment "A week is a period of 7 consecutive days." ;
  rdfs:subClassOf sio:TimeInterval .

sio:Width a owl:Class ;
  rdfs:comment """width is the shorter dimensional extent perpendicular to a 2D projection of the object.
""" ;
  rdfs:subClassOf sio:1DExtentQuantity .

sio:Wonder a owl:Class ;
  rdfs:comment """wonder is an emotion of perceiving something very rare or unexpected, but not threatening.
""" ;
  rdfs:subClassOf sio:Surprise .

sio:Word a owl:Class ;
  rdfs:comment """A word is the smallest free form (an item that may be expressed in isolation with semantic or pragmatic content) in a language.
""" ;
  rdfs:subClassOf sio:LanguageEntity .

sio:WordEndPosition a owl:Class ;
  rdfs:comment """word end position is the position of the last character in a word as an offset from the first character of the text in which it is found.
""" ;
  rdfs:subClassOf sio:TextSpanEndPosition .

sio:WordStartPosition a owl:Class ;
  rdfs:comment """The position of the first character in a word as an offset from the first character of the text in which it is found.
""" ;
  rdfs:subClassOf sio:TextSpanStartPosition .

sio:WordTree a owl:Class ;
  rdfs:comment """A word tree is a chart that links phrases with contexts through a tree-like branching structure.
""" ;
  rdfs:subClassOf sio:TextualChart .

sio:WorkPhoneNumber a owl:Class ;
  rdfs:comment "a work phone number is the number to connect to an phone at a place of work." ;
  rdfs:subClassOf sio:TelephoneNumber .

sio:Workflow a owl:Class ;
  rdfs:comment """A workflow is an algorithm that is is a depiction of a sequence of operations to achieve one or more objectives.
""" ;
  rdfs:subClassOf sio:Algorithm .

sio:Worm a owl:Class ;
  rdfs:comment """A worm is a non-arthropod invertebrate animal that typically have a long cylindrical tube-like body and no legs.
""" ;
  rdfs:subClassOf sio:MulticellularOrganism .

sio:Worry a owl:Class ;
  rdfs:comment "worry is the emotion characterized by concer over a real or imaginary issue." ;
  rdfs:subClassOf sio:Apprehension .

sio:Written a owl:Class ;
  rdfs:comment """written is the quality of information that is embodied as visual glyphs in some material form.
""" ;
  rdfs:subClassOf sio:TextQuality .

sio:WrittenLanguage a owl:Class ;
  rdfs:comment "written language is a language that is communicated through a writing system." ;
  rdfs:subClassOf sio:Language .

sio:XAxis a owl:Class ;
  rdfs:comment "An x-axis is a Cartesian coordinate axis that is aligned with the horizon." ;
  rdfs:subClassOf sio:CartesianCoordinateAxis .

sio:XCartesianCoordinate a owl:Class ;
  rdfs:comment """An x cartesian coordinate is the coordinate of an object onto the x-axis of a cartesian coordinate system.
""" ;
  rdfs:subClassOf sio:CartesianCoordinate .

sio:XenonAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:YAxis a owl:Class ;
  rdfs:comment """A y-axis is a Cartesian coordinate axis that is spatially oriented perpendicular to the x-axis.
""" ;
  rdfs:subClassOf sio:CartesianCoordinateAxis .

sio:YCartesianCoordinate a owl:Class ;
  rdfs:comment """An y cartesian coordinate is the coordinate of an object onto the y-axis of a cartesian coordinate system.
""" ;
  rdfs:subClassOf sio:CartesianCoordinate .

sio:Year a owl:Class ;
  rdfs:comment """A year is a period of time taken by a planet to make one revolution around the sun.
""" ;
  rdfs:subClassOf sio:TimeInterval .

sio:YtterbiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:YttriumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:ZAxis a owl:Class ;
  rdfs:comment """A z-axis is a Cartesian coordinate axis that is spatially oriented normal to the plane formed by the x- and y-axes.
""" ;
  rdfs:subClassOf sio:CartesianCoordinateAxis .

sio:ZCartesianCoordinate a owl:Class ;
  rdfs:comment """A z cartesian coordinate is the coordinate of an object onto the z-axis of a cartesian coordinate system.
""" ;
  rdfs:subClassOf sio:CartesianCoordinate .

sio:ZincAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:ZirconiumAtom a owl:Class ;
  rdfs:comment "None" ;
  rdfs:subClassOf sio:Atom .

sio:Zygosity a owl:Class ;
  rdfs:comment """zygosity is the quality pertaining to the allelic complement of a biological system at a single locus on the DNA.
""" ;
  rdfs:subClassOf sio:BiologicalQuality .

sio:affects a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:has_output ;
  a owl:FunctionalProperty .

sio:cites a owl:ObjectProperty ;
  rdfs:comment "cites is a relation to refer to by way of example, authority or proof." ;
  rdfs:subPropertyOf sio:references ;
  a owl:FunctionalProperty .

sio:contains a owl:ObjectProperty ;
  rdfs:comment """A contains B iff the spatial region occupied by A has the spatial region occupied by B as a part, and B is not part of A. [T]
""" ;
  rdfs:subPropertyOf sio:is_location_of ;
  a owl:FunctionalProperty .

sio:denotes a owl:ObjectProperty ;
  rdfs:comment """denotes is a relation between an entity and what it is a sign or indication of, or what specifically means.
""" ;
  rdfs:subPropertyOf sio:represents ;
  a owl:FunctionalProperty .

sio:derives_into a owl:ObjectProperty ;
  rdfs:comment """a derives to b if and only if a or some part thereof is consumed in the formation of b.
""" ;
  rdfs:range sio:Object ;
  rdfs:domain sio:Object ;
  rdfs:subPropertyOf sio:is_causally_related_to ;
  a owl:FunctionalProperty .

sio:describes a owl:ObjectProperty ;
  rdfs:comment """describes is a relation between one entity and another entity that it provides a description (detailed account of).
""" ;
  rdfs:subPropertyOf sio:refers_to ;
  a owl:FunctionalProperty .

sio:encodes a owl:ObjectProperty ;
  rdfs:comment """A relation between two objects, in which the first object contains information that is used to produce the second object.
""" ;
  rdfs:subPropertyOf sio:specifies ;
  a owl:FunctionalProperty .

sio:exists_at a owl:ObjectProperty ;
  rdfs:comment "exists at is a relation between an entity and a time measurement." ;
  rdfs:range sio:TimeMeasurement ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:has_agent a owl:ObjectProperty ;
  rdfs:comment """has agent is a relation between a process and an entity, where the entity is present throughout the process and is a causal participant in the process.
""" ;
  rdfs:subPropertyOf sio:has_participant ;
  a owl:FunctionalProperty .

sio:has_annotation a owl:ObjectProperty ;
  rdfs:comment "has annotation is a relation between an entity and some textual anntotation." ;
  rdfs:range sio:LanguageEntity ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_attribute a owl:ObjectProperty ;
  rdfs:comment """has attribute is a relation that associates a entity with an attribute where an attribute is an intrinsic characteristic such as a quality, capability, disposition, function, or is an externally derived attribute determined from some descriptor (e.g. a quantity, position, label/identifier) either directly or indirectly through generalization of entities of the same type.
""" ;
  rdfs:domain sio:Entity ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:has_basis a owl:ObjectProperty ;
  rdfs:comment """has basis is a relation between a realizable entity and the quality that forms the basis for it.
""" ;
  rdfs:range sio:Quality ;
  rdfs:domain sio:RealizableEntity ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_boundary a owl:ObjectProperty ;
  rdfs:comment """has boundary is a mereological relation between a whole and boundary located at its periphery.
""" ;
  rdfs:subPropertyOf sio:has_proper_part ;
  a owl:FunctionalProperty .

sio:has_capability a owl:ObjectProperty ;
  rdfs:comment "has capability is a relation between an entity and the capability that it bears." ;
  rdfs:range sio:Capability ;
  rdfs:subPropertyOf sio:has_realizable_property ;
  a owl:FunctionalProperty .

sio:has_component_part a owl:ObjectProperty ;
  rdfs:comment """has component part is a relation between a whole and a component part where the component is instrinsic to the whole, and loss of the part would change the kind that it is.
""" ;
  rdfs:subPropertyOf sio:has_direct_part ;
  a owl:FunctionalProperty .

sio:has_concretization a owl:ObjectProperty ;
  rdfs:comment """A has concretization B iff A is an informational entity and B is the a quality of some material entity.
""" ;
  rdfs:subPropertyOf sio:is_generically_related_with ;
  a owl:FunctionalProperty .

sio:has_creator a owl:ObjectProperty ;
  rdfs:comment "has creator is a relation between an entity and that which created it." ;
  rdfs:range sio:Entity ;
  rdfs:domain sio:Entity ;
  rdfs:subPropertyOf sio:has_source ;
  a owl:FunctionalProperty .

sio:has_data_item a owl:ObjectProperty ;
  rdfs:comment """has data item is a relation between a dataset and any described / referrenced entity.
""" ;
  rdfs:domain sio:Dataset ;
  rdfs:subPropertyOf sio:refers_to ;
  a owl:FunctionalProperty .

sio:has_direct_part a owl:ObjectProperty ;
  rdfs:comment """has direct part is a relation to specify a part at a particular level of granularity
""" ;
  rdfs:subPropertyOf sio:has_proper_part ;
  a owl:FunctionalProperty .

sio:has_disposition a owl:ObjectProperty ;
  rdfs:comment """has disposition is the relation between an entity and a disposition that it bears.
""" ;
  rdfs:range sio:Disposition ;
  rdfs:subPropertyOf sio:has_capability ;
  a owl:FunctionalProperty .

sio:has_end_time a owl:ObjectProperty ;
  rdfs:range sio:TimeInstant ;
  rdfs:subPropertyOf sio:has_time_boundary ;
  a owl:FunctionalProperty .

sio:has_evidence a owl:ObjectProperty ;
  rdfs:comment """has evidence is a relation between a proposition and something that demonstrates the truth of the assertion.
""" ;
  rdfs:subPropertyOf sio:references ;
  a owl:FunctionalProperty .

sio:has_expression a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_generically_related_with ;
  a owl:FunctionalProperty .

sio:has_first_part a owl:ObjectProperty ;
  rdfs:comment """has first part is a proper part relation in which the part is the first of a set of linearly ordered parts resulting from the projection of the whole on a linear coordinate system.
""" ;
  rdfs:subPropertyOf sio:has_ordered_part ;
  a owl:FunctionalProperty .

sio:has_frequency a owl:ObjectProperty ;
  rdfs:comment "has frequency is a relation that specifies the occurence of an object or event" ;
  rdfs:subPropertyOf sio:has_measurement_value ;
  a owl:FunctionalProperty .

sio:has_function a owl:ObjectProperty ;
  rdfs:comment """has function is the relation between an entity and a function that is ascribed to it.
""" ;
  rdfs:range sio:Function ;
  rdfs:subPropertyOf sio:has_disposition ;
  a owl:FunctionalProperty .

sio:has_identifier a owl:ObjectProperty ;
  rdfs:comment "a relation between an entity and an identifier." ;
  rdfs:range sio:Identifier ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_implementation a owl:ObjectProperty ;
  rdfs:comment """has implementation is a relation between a specification and an implementation that conforms to it.
""" ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_input a owl:ObjectProperty ;
  rdfs:comment """has input is a relation between a process and an entity, where the entity is present at the beginning of the process.
""" ;
  rdfs:subPropertyOf sio:has_participant ;
  a owl:FunctionalProperty .

sio:has_last_part a owl:ObjectProperty ;
  rdfs:comment """has last part is a proper part relation in which the part is the last of a set of linearly ordered parts resulting from the projection of the whole on a linear coordinate system.
""" ;
  rdfs:subPropertyOf sio:has_ordered_part ;
  a owl:FunctionalProperty .

sio:has_measurement_value a owl:ObjectProperty ;
  rdfs:comment """has measurement value is a relation between a quality/realizable and a measurement value.
""" ;
  rdfs:range sio:MeasurementValue ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_member a owl:ObjectProperty ;
  rdfs:comment "has member is a mereological relation between a collection and an item." ;
  rdfs:domain sio:Collection ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_ordered_part a owl:ObjectProperty ;
  rdfs:comment """has ordered part of is a proper part relation in which the part is one of a set of linearly ordered parts resulting from the projection of the whole on a linear coordinate system.
""" ;
  rdfs:subPropertyOf sio:has_proper_part ;
  a owl:FunctionalProperty .

sio:has_output a owl:ObjectProperty ;
  rdfs:comment """has output is a relation between an process and an entity, where the entity is present at the end of the process.
""" ;
  rdfs:subPropertyOf sio:has_participant ;
  a owl:FunctionalProperty .

sio:has_parameter a owl:ObjectProperty ;
  rdfs:comment """has parameter is a relation between a process and an information content entity which modulates the behaviour of some participant.
""" ;
  rdfs:subPropertyOf sio:has_input ;
  a owl:FunctionalProperty .

sio:has_part a owl:ObjectProperty ;
  rdfs:comment """has part is a transitive, reflexive and antisymmetric relation between a whole and itself or a whole and its part.
""" ;
  rdfs:subPropertyOf sio:is_location_of ;
  a owl:FunctionalProperty .

sio:has_participant a owl:ObjectProperty ;
  rdfs:comment """has participant is a relation that describes the participation of the object in the (processual) subject.
""" ;
  rdfs:domain sio:Process ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:has_phenotype a owl:ObjectProperty ;
  rdfs:comment """has phenotype is a relation between an object and an observable/measurable characteristic.
""" ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_product a owl:ObjectProperty ;
  rdfs:comment """has product is a relation between an process and an entity, where a new entity exists at the end of the process.
""" ;
  rdfs:subPropertyOf sio:has_output ;
  a owl:FunctionalProperty .

sio:has_proper_part a owl:ObjectProperty ;
  rdfs:comment """has proper part is an antisymmetric, irreflexive (normally transitive) relation between a whole and a distinct part.
""" ;
  rdfs:subPropertyOf sio:has_part ;
  a owl:FunctionalProperty .

sio:has_property a owl:ObjectProperty ;
  rdfs:comment """has property is a relation between an entity and the quality, capability or role that it and it alone bears.
""" ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_provider a owl:ObjectProperty ;
  rdfs:comment "is provided by is a relation between an entity and the entity that provides it." ;
  rdfs:subPropertyOf sio:has_source ;
  a owl:FunctionalProperty .

sio:has_quality a owl:ObjectProperty ;
  rdfs:comment "has quality is a relation between an entity and the quality that it bears." ;
  rdfs:range sio:Quality ;
  rdfs:subPropertyOf sio:has_property ;
  a owl:FunctionalProperty .

sio:has_realizable_property a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:has_property ;
  a owl:FunctionalProperty .

sio:has_role a owl:ObjectProperty ;
  rdfs:comment "has role is a relation between an entity and a role that it bears." ;
  rdfs:range sio:Role ;
  rdfs:subPropertyOf sio:has_realizable_property ;
  a owl:FunctionalProperty .

sio:has_source a owl:ObjectProperty ;
  rdfs:comment """has source is a relation between an entity and another entity from which it stems from.
""" ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:has_start_time a owl:ObjectProperty ;
  rdfs:range sio:TimeInstant ;
  rdfs:subPropertyOf sio:has_time_boundary ;
  a owl:FunctionalProperty .

sio:has_substrate a owl:ObjectProperty ;
  rdfs:comment """has substrate is a relation between a process and an object where the object is destroyed by its participation in the process.
""" ;
  rdfs:subPropertyOf sio:has_target ;
  a owl:FunctionalProperty .

sio:has_target a owl:ObjectProperty ;
  rdfs:comment """has target is a relation between a process and an entity, where the entity is present at the beginning  of the process and undergoes a change or transformation in the process.
""" ;
  rdfs:subPropertyOf sio:has_input ;
  a owl:FunctionalProperty .

sio:has_time_boundary a owl:ObjectProperty ;
  rdfs:range sio:TimeInstant ;
  rdfs:subPropertyOf sio:has_boundary ;
  a owl:FunctionalProperty .

sio:has_trigger a owl:ObjectProperty ;
  rdfs:comment """has trigger is a relation between a realizable and the factor that causes it to be realized.
""" ;
  rdfs:subPropertyOf sio:is_causally_related_to ;
  a owl:FunctionalProperty .

sio:has_unique_identifier a owl:ObjectProperty ;
  rdfs:comment """has unique identifier is an inverse functional relation between an entity and an identifier that uniquely identifies it.
""" ;
  rdfs:range sio:UniqueIdentifier ;
  rdfs:subPropertyOf sio:has_identifier ;
  a owl:FunctionalProperty .

sio:has_unit a owl:ObjectProperty ;
  rdfs:comment "has unit is a relation between a quantity and the unit it is a multiple of." ;
  rdfs:range sio:UnitOfMeasurement ;
  rdfs:domain sio:MathematicalEntity ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:immediately_derives_into a owl:ObjectProperty ;
  rdfs:comment """a immediately derives into b if and only if a or some significant part thereof is consumed in the formation of b and there are no identifiable intermediate entities between a and b.
""" ;
  rdfs:subPropertyOf sio:derives_into ;
  a owl:FunctionalProperty .

sio:immediately_precedes a owl:ObjectProperty ;
  rdfs:comment """A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes.
""" ;
  rdfs:subPropertyOf sio:precedes ;
  a owl:FunctionalProperty .

sio:immediately_transforms_into a owl:ObjectProperty ;
  rdfs:comment """A  temporal relation in which an entity mainstains identity from one state to another.
""" ;
  rdfs:subPropertyOf sio:transforms_into ;
  a owl:FunctionalProperty .

sio:in_relation_from a owl:ObjectProperty ;
  rdfs:comment """a in relation from b is a comparative relation in a is the object of reference in a relation with b. 
""" ;
  rdfs:subPropertyOf sio:is_referred_to_by ;
  a owl:FunctionalProperty .

sio:in_relation_to a owl:ObjectProperty ;
  rdfs:comment """in relation to is a comparative relation to indicate that the instance of the class holding the relation exists in relation to another entity.
""" ;
  rdfs:subPropertyOf sio:refers_to ;
  a owl:FunctionalProperty .

sio:is_about a owl:ObjectProperty ;
  rdfs:comment """is about is a relation between an information content entity and the entity that its primary subject.
""" ;
  rdfs:subPropertyOf sio:describes ;
  a owl:FunctionalProperty .

sio:is_adjacent_to a owl:ObjectProperty ;
  rdfs:comment "A is adjacent to B iff there is a small, but non-zero distance between A and B" ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:is_affected_by a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_participant_in ;
  a owl:FunctionalProperty .

sio:is_agent_in a owl:ObjectProperty ;
  rdfs:comment """is agent in is a relation between an entity and a process, where the entity is present throughout the process, no permanent material change occurs, and is a causal participant in the process.
""" ;
  rdfs:subPropertyOf sio:is_participant_in ;
  a owl:FunctionalProperty .

sio:is_alternate_of a owl:ObjectProperty ;
  rdfs:comment "is alternate of relates two specialized instances." ;
  rdfs:subPropertyOf sio:is_variant_of ;
  a owl:FunctionalProperty .

sio:is_annotation_of a owl:ObjectProperty ;
  rdfs:comment """is annotation of is a relation between some textual entity and the entity that it annotates.
""" ;
  rdfs:domain sio:LanguageEntity ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_associated_with a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:is_attribute_of a owl:ObjectProperty ;
  rdfs:comment """is attribute of is a relation that associates an attribute with an entity where an attribute is an intrinsic characteristic such as a quality, capability, disposition, function, or is an externally derived attribute determined from some descriptor (e.g. a quantity, position, label/identifier) either directly or indirectly through generalization of entities of the same type.
""" ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:is_base_for a owl:ObjectProperty ;
  rdfs:comment """is base for is a relation between a quality and the realizable entity that it is the basis for.
""" ;
  rdfs:range sio:RealizableEntity ;
  rdfs:domain sio:Quality ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_boundary_of a owl:ObjectProperty ;
  rdfs:comment """is boundary of is a mereological relation between a boundary located at the periphery of a whole.
""" ;
  rdfs:subPropertyOf sio:is_proper_part_of ;
  a owl:FunctionalProperty .

sio:is_broad_match_to a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_match_to ;
  a owl:FunctionalProperty .

sio:is_broader_than a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_broader_thant ;
  a owl:FunctionalProperty .

sio:is_broader_thant a owl:ObjectProperty ;
  rdfs:comment "A is broader than B (t) iff for A is broader than B." ;
  rdfs:range sio:Term ;
  rdfs:domain sio:Term ;
  rdfs:subPropertyOf sio:is_similar_to ;
  a owl:FunctionalProperty .

sio:is_capability_of a owl:ObjectProperty ;
  rdfs:comment """is capability of is a relation between a capability and the entity that bears it.
""" ;
  rdfs:domain sio:Capability ;
  rdfs:subPropertyOf sio:is_realizable_property_of ;
  a owl:FunctionalProperty .

sio:is_causally_related_from a owl:ObjectProperty ;
  rdfs:comment "a is causally related from b iff there is a causal chain of events from b to a" ;
  rdfs:subPropertyOf sio:is_causally_related_with ;
  a owl:FunctionalProperty .

sio:is_causally_related_to a owl:ObjectProperty ;
  rdfs:comment "a is causally related to b iff there is a causal chain of events from a to b" ;
  rdfs:subPropertyOf sio:is_causally_related_with ;
  a owl:FunctionalProperty .

sio:is_causally_related_with a owl:ObjectProperty ;
  rdfs:comment """A transitive, symmetric, temporal relation in which one entity is causally related with another non-identical entity.
""" ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:is_cited_by a owl:ObjectProperty ;
  rdfs:comment """is cited by is a relation from an object that is referred to by way of example, authority or proof.
""" ;
  rdfs:subPropertyOf sio:is_referenced_by ;
  a owl:FunctionalProperty .

sio:is_close_match_to a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_match_to ;
  a owl:FunctionalProperty .

sio:is_comparable_to a owl:ObjectProperty ;
  rdfs:comment """is comparable to is a relation between two entities that share at least one feature whose value can be compared.
""" ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:is_component_part_of a owl:ObjectProperty ;
  rdfs:comment """is component part of is a relation between a component and a whole, where the component is instrinsic to the whole, and loss of the part would change the kind that the whole is.
""" ;
  rdfs:subPropertyOf sio:is_direct_part_of ;
  a owl:FunctionalProperty .

sio:is_concretization_of a owl:ObjectProperty ;
  rdfs:comment """A is concretization of B iff A is a quality of a material entity and B is an informational entity.
""" ;
  rdfs:subPropertyOf sio:is_generically_related_with ;
  a owl:FunctionalProperty .

sio:is_connected_to a owl:ObjectProperty ;
  rdfs:comment """A is connected to B iff there exists a fiat, material or temporal path between A and B. [S][T]
""" ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:is_contained_in a owl:ObjectProperty ;
  rdfs:comment """A is contained in B iff the spatial region occupied by A is part of the spatial region occupied by B and A is not part of B. [T]
""" ;
  rdfs:subPropertyOf sio:is_located_in ;
  a owl:FunctionalProperty .

sio:is_correlated_with a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_associated_with ;
  a owl:FunctionalProperty .

sio:is_covalently_connected_to a owl:ObjectProperty ;
  rdfs:comment "is covalently connected to is a relation between an atom and another atom." ;
  rdfs:seeAlso sio:isCovalentlyConnectedTotransitive ;
  rdfs:subPropertyOf sio:is_directly_connected_to ;
  a owl:FunctionalProperty .

sio:is_covalently_connected_totransitive a owl:ObjectProperty ;
  rdfs:range sio:Atom ;
  rdfs:domain sio:Atom ;
  rdfs:subPropertyOf sio:is_connected_to ;
  a owl:FunctionalProperty .

sio:is_creator_of a owl:ObjectProperty ;
  rdfs:comment "is creator of is a relation between a creator and an entity.." ;
  rdfs:subPropertyOf sio:is_source_of ;
  a owl:FunctionalProperty .

sio:is_data_item_in a owl:ObjectProperty ;
  rdfs:comment """'is data item in' is a relation between an entity that is described or referenced in a dataset.
""" ;
  rdfs:range sio:Dataset ;
  rdfs:subPropertyOf sio:refers_to ;
  a owl:FunctionalProperty .

sio:is_denoted_by a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_represented_by ;
  a owl:FunctionalProperty .

sio:is_derived_from a owl:ObjectProperty ;
  rdfs:comment """A transitive temporal relation in which one entity was materially formed from another non-identical entity.
""" ;
  rdfs:subPropertyOf sio:is_causally_related_from ;
  a owl:FunctionalProperty .

sio:is_described_by a owl:ObjectProperty ;
  rdfs:comment """is described by is a relation between one entity and another entity that provides a description (detailed account) of it.
""" ;
  rdfs:subPropertyOf sio:is_referred_to_by ;
  a owl:FunctionalProperty .

sio:is_direct_part_of a owl:ObjectProperty ;
  rdfs:comment """is direct part of is a relation between a specific part (at some level of granularity) and its whole.
""" ;
  rdfs:subPropertyOf sio:is_proper_part_of ;
  a owl:FunctionalProperty .

sio:is_directly_after a owl:ObjectProperty ;
  rdfs:comment """is directly after is a relation between entities placed on a dimensional axis in which the projection of the position of the first entity is numerically greater than the projection of the position of the second entity, and the entities are adjacent to one another.
""" ;
  rdfs:seeAlso sio:isPositionallyAfter ;
  rdfs:subPropertyOf sio:is_directly_connected_to ;
  a owl:FunctionalProperty .

sio:is_directly_before a owl:ObjectProperty ;
  rdfs:comment """is directly before is a relation between entities placed on a dimensional axis in which the projection of the position of the first entity is numerically less than the projection of the position of the second entity, and the entities are adjacent to one another.
""" ;
  rdfs:seeAlso sio:isDirectlyConnectedTo ;
  rdfs:subPropertyOf sio:is_positionally_before ;
  a owl:FunctionalProperty .

sio:is_directly_connected_to a owl:ObjectProperty ;
  rdfs:comment "A is directly connected to B iff there exists a path direclty between A and B." ;
  rdfs:subPropertyOf sio:is_connected_to ;
  a owl:FunctionalProperty .

sio:is_disposition_of a owl:ObjectProperty ;
  rdfs:comment """is disposition of is a relation between a disposition and the entity that it is a property of.
""" ;
  rdfs:domain sio:Disposition ;
  rdfs:subPropertyOf sio:is_capability_of ;
  a owl:FunctionalProperty .

sio:is_disputed_by a owl:ObjectProperty ;
  rdfs:comment """has disputing evidence is a relation between a proposition and something that disputes (does not directly support) the truth of the assertion.
""" ;
  rdfs:subPropertyOf sio:has_evidence ;
  a owl:FunctionalProperty .

sio:is_disputing_evidence_for a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_evidence_for ;
  a owl:FunctionalProperty .

sio:is_dissimilar_to a owl:ObjectProperty ;
  rdfs:comment """is dissimilar to is a relation between two entities in which one is considered dissimilar to the other based on some criteria.
""" ;
  rdfs:subPropertyOf sio:is_variant_of ;
  a owl:FunctionalProperty .

sio:is_encoded_by a owl:ObjectProperty ;
  rdfs:comment """A relation between two objects, in which the first object is produced from the information contained in the second object.
""" ;
  rdfs:subPropertyOf sio:is_specified_by ;
  a owl:FunctionalProperty .

sio:is_end_time_of a owl:ObjectProperty ;
  rdfs:domain sio:TimeInstant ;
  rdfs:subPropertyOf sio:is_time_boundary_of ;
  a owl:FunctionalProperty .

sio:is_equal_to a owl:ObjectProperty ;
  rdfs:comment """is equal to is a comparison relation between two quantities whose value are exactly the same.
""" ;
  rdfs:subPropertyOf sio:is_numerically_comparable_to ;
  a owl:FunctionalProperty .

sio:is_evidence_for a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_referenced_by ;
  a owl:FunctionalProperty .

sio:is_exact_match_to a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_match_to ;
  a owl:FunctionalProperty .

sio:is_expression_of a owl:ObjectProperty ;
  rdfs:comment """is expression of is a relation between more concrete expression of some conceptualization.
""" ;
  rdfs:subPropertyOf sio:is_generically_related_with ;
  a owl:FunctionalProperty .

sio:is_first_part_of a owl:ObjectProperty ;
  rdfs:comment """is first part of is a proper part relation in which the part is the first of a set of linearly ordered parts resulting from the projection of the whole on a linear coordinate system.
""" ;
  rdfs:subPropertyOf sio:is_ordered_part_of ;
  a owl:FunctionalProperty .

sio:is_frequency_of a owl:ObjectProperty ;
  rdfs:comment "is frequency of is a relation between a temporal unit and an object or event" ;
  rdfs:subPropertyOf sio:is_measurement_value_of ;
  a owl:FunctionalProperty .

sio:is_function_of a owl:ObjectProperty ;
  rdfs:comment """is function of is a relation between a function and an entity that it is a property of.
""" ;
  rdfs:domain sio:Function ;
  rdfs:subPropertyOf sio:is_disposition_of ;
  a owl:FunctionalProperty .

sio:is_generalization_of a owl:ObjectProperty ;
  rdfs:comment """is generalization of is a relation between a more general instance (in terms of spatial/temporal localization & other attributres) than the other.
""" ;
  rdfs:subPropertyOf sio:is_variant_of ;
  a owl:FunctionalProperty .

sio:is_generically_related_with a owl:ObjectProperty ;
  rdfs:comment """A is generically related with B iff A is an abstract entity or an information content entity and B is a information content entity or a physical entity, respectively.
""" ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:is_greater_than a owl:ObjectProperty ;
  rdfs:comment """is greater than to is a comparison relation between two quantities in which the first has a value larger than the second.
""" ;
  rdfs:subPropertyOf sio:is_greater_than_or_equal_to ;
  a owl:FunctionalProperty .

sio:is_greater_than_or_equal_to a owl:ObjectProperty ;
  rdfs:comment """is greater than or equal to is a comparison relation between two quantities in which the first has a value larger or equal to the second.
""" ;
  rdfs:subPropertyOf sio:is_numerically_comparable_to ;
  a owl:FunctionalProperty .

sio:is_homologous_to a owl:ObjectProperty ;
  rdfs:comment "a relation between two entities which indicates their common ancestry." ;
  rdfs:subPropertyOf sio:is_variant_of ;
  a owl:FunctionalProperty .

sio:is_identical_to a owl:ObjectProperty ;
  rdfs:comment """is identical to is a relation between two objects that are conceptually the same notwithstanding provenance or other non-intrinsic attributes.
""" ;
  rdfs:subPropertyOf sio:is_comparable_to ;
  a owl:FunctionalProperty .

sio:is_identifier_for a owl:ObjectProperty ;
  rdfs:comment "a relation between an identifier and an entity." ;
  rdfs:domain sio:Identifier ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_immediately_derived_from a owl:ObjectProperty ;
  rdfs:comment """A non-transitive temporal relation in which one entity is immediately derived from a non-identical entity such that there are no intermediate entities between them.
""" ;
  rdfs:subPropertyOf sio:is_derived_from ;
  a owl:FunctionalProperty .

sio:is_immediately_preceded_by a owl:ObjectProperty ;
  rdfs:comment """A non-transitive temporal relation in which one process is immediately preceded by another process, such that there is no interval of time between the two processes.
""" ;
  rdfs:subPropertyOf sio:is_preceded_by ;
  a owl:FunctionalProperty .

sio:is_immediately_transformed_from a owl:ObjectProperty ;
  rdfs:comment """A  temporal relation in which an entity mainstains identity from one state to another.
""" ;
  rdfs:subPropertyOf sio:is_transformed_from ;
  a owl:FunctionalProperty .

sio:is_implementation_of a owl:ObjectProperty ;
  rdfs:comment """is implementation of is a relation between an information entity and a specification that it conforms to.
""" ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_inequal_to a owl:ObjectProperty ;
  rdfs:comment """is inequal to is a comparison relation between two quantities whose value are not the same.
""" ;
  rdfs:subPropertyOf sio:is_numerically_comparable_to ;
  a owl:FunctionalProperty .

sio:is_input_in a owl:ObjectProperty ;
  rdfs:comment """is input in is a relation between an entity and a process, where the entity is present at the beginning of the process.
""" ;
  rdfs:subPropertyOf sio:is_participant_in ;
  a owl:FunctionalProperty .

sio:is_last_part_of a owl:ObjectProperty ;
  rdfs:comment """is last part of is a proper part relation in which the part is the last of a set of linearly ordered parts resulting from the projection of the whole on a linear coordinate system.
""" ;
  rdfs:subPropertyOf sio:is_ordered_part_of ;
  a owl:FunctionalProperty .

sio:is_lesser_than a owl:ObjectProperty ;
  rdfs:comment """is lesser than to is a comparison relation between two quantities in which the first has a value smaller than the second.
""" ;
  rdfs:subPropertyOf sio:is_lesser_than_or_equal_to ;
  a owl:FunctionalProperty .

sio:is_lesser_than_or_equal_to a owl:ObjectProperty ;
  rdfs:comment """is greater than to is a comparison relation between two quantities in which the first has a value smaller or equal to the second.
""" ;
  rdfs:subPropertyOf sio:is_numerically_comparable_to ;
  a owl:FunctionalProperty .

sio:is_located_in a owl:ObjectProperty ;
  rdfs:comment """A is located in B iff the spatialtemporial region occupied by A is part of the spatialtemporal region occupied by B. [T][R]
""" ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:is_location_of a owl:ObjectProperty ;
  rdfs:comment """A is location of B iff the spatialtemporal region occupied by A has the spatialtemporal region occupied by B as a part. [T][R]
""" ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:is_manifestation_of a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_generically_related_with ;
  a owl:FunctionalProperty .

sio:is_manifested_as a owl:ObjectProperty ;
  rdfs:comment "is manifested as is a relation between an expression and its manifestations." ;
  rdfs:subPropertyOf sio:is_generically_related_with ;
  a owl:FunctionalProperty .

sio:is_match_to a owl:ObjectProperty ;
  rdfs:comment """A is match to B iff A and B are terms with similar (related, broad, close, exact) meanings
""" ;
  rdfs:range sio:Term ;
  rdfs:domain sio:Term ;
  rdfs:subPropertyOf sio:is_similar_to ;
  a owl:FunctionalProperty .

sio:is_measurement_value_of a owl:ObjectProperty ;
  rdfs:comment """is measurement value of is a relation between a value and the entity that it is a measurement of.
""" ;
  rdfs:domain sio:MeasurementValue ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_member_of a owl:ObjectProperty ;
  rdfs:comment "is member of is a mereological relation between a item and a collection." ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_model_of a owl:ObjectProperty ;
  rdfs:comment """is model of is a relation between a model (an artifact) and the entity it purports to represent.
""" ;
  rdfs:subPropertyOf sio:represents ;
  a owl:FunctionalProperty .

sio:is_modelled_by a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_represented_by ;
  a owl:FunctionalProperty .

sio:is_mutual_capability_of a owl:ObjectProperty ;
  rdfs:comment """a is mutual capability of b if and only if the realization of capability  a necessarily causes the realization of capability b.
""" ;
  rdfs:subPropertyOf sio:is_mutually_related_to ;
  a owl:FunctionalProperty .

sio:is_mutual_disposition_of a owl:ObjectProperty ;
  rdfs:comment """a is mutual disposition of b if and only if the realization of the disposition  a necessarily causes the realization of the disposition b.
""" ;
  rdfs:subPropertyOf sio:is_mutually_related_to ;
  a owl:FunctionalProperty .

sio:is_mutual_role_of a owl:ObjectProperty ;
  rdfs:comment """a is mutual role of b if and only if the realization of role  a necessarily causes the realization of role b.
""" ;
  rdfs:subPropertyOf sio:is_mutually_related_to ;
  a owl:FunctionalProperty .

sio:is_mutually_related_to a owl:ObjectProperty ;
  rdfs:comment """a is mutually related to b if and only if the realization of the relation of a necessarily causes the realization of a relation to b.
""" ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:is_narrower_than a owl:ObjectProperty ;
  rdfs:comment """A is narrower than B iff the meaning of term A is narrower in scope than the meaning of term B
""" ;
  rdfs:subPropertyOf sio:is_narrower_thant ;
  a owl:FunctionalProperty .

sio:is_narrower_thant a owl:ObjectProperty ;
  rdfs:comment "A is narrower than B (t) iff for A is narrower than B." ;
  rdfs:range sio:Term ;
  rdfs:domain sio:Term ;
  rdfs:subPropertyOf sio:is_similar_to ;
  a owl:FunctionalProperty .

sio:is_numerically_comparable_to a owl:ObjectProperty ;
  rdfs:comment """is numerically comparable to is a comparison relation between two quantities whose datatype value can be compared.
""" ;
  rdfs:range sio:Quantity ;
  rdfs:domain sio:Quantity ;
  rdfs:subPropertyOf sio:is_comparable_to ;
  a owl:FunctionalProperty .

sio:is_opposite_to a owl:ObjectProperty ;
  rdfs:comment """is opposite to is a relation between two entities in which one is diametrically opposed to the other. 
""" ;
  rdfs:subPropertyOf sio:is_dissimilar_to ;
  a owl:FunctionalProperty .

sio:is_ordered_part_of a owl:ObjectProperty ;
  rdfs:comment """is ordered part of is a proper part relation in which the part is one of a set of linearly ordered parts resulting from the projection of the whole on a linear coordinate system.
""" ;
  rdfs:subPropertyOf sio:is_proper_part_of ;
  a owl:FunctionalProperty .

sio:is_orthologous_to a owl:ObjectProperty ;
  rdfs:comment """is orthologous to is a relation between two biological entities that share a common ancestor and occur in different species.
""" ;
  rdfs:subPropertyOf sio:is_homologous_to ;
  a owl:FunctionalProperty .

sio:is_output_of a owl:ObjectProperty ;
  rdfs:comment """is output of is a relation between an entity and a process, where the entity is present at the end of the process.
""" ;
  rdfs:subPropertyOf sio:is_participant_in ;
  a owl:FunctionalProperty .

sio:is_paralogous_to a owl:ObjectProperty ;
  rdfs:comment """is paralogous to is a relation between two entities which indicates their common ancestry as a result of a gene duplication.
""" ;
  rdfs:subPropertyOf sio:is_homologous_to ;
  a owl:FunctionalProperty .

sio:is_parameter_in a owl:ObjectProperty ;
  rdfs:comment """is parameter in is a relation between a data item and some data transformation process.
""" ;
  rdfs:subPropertyOf sio:is_input_in ;
  a owl:FunctionalProperty .

sio:is_part_of a owl:ObjectProperty ;
  rdfs:comment """is part of is a transitive, reflexive and anti-symmetric mereological relation between a whole and itself or a part and its whole.
""" ;
  rdfs:subPropertyOf sio:is_located_in ;
  a owl:FunctionalProperty .

sio:is_participant_in a owl:ObjectProperty ;
  rdfs:comment """is participant in is a relation that describes the participation of the subject in the (processual) object.
""" ;
  rdfs:range sio:Process ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:is_phenotype_of a owl:ObjectProperty ;
  rdfs:comment """is phenotype of is a relation between an observable/measurable characteristic and an object.
""" ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_positionally_after a owl:ObjectProperty ;
  rdfs:comment """is positionally after is a relation between entities placed on a dimensional axis in which the projection of the position of the first entity is numerically greater than the projection of the position of the second entity.
""" ;
  rdfs:subPropertyOf sio:is_connected_to ;
  a owl:FunctionalProperty .

sio:is_positionally_before a owl:ObjectProperty ;
  rdfs:comment """is positionally before is a relation between entities placed on a dimensional axis in which the projection of the position of the first entity is numerically less than the projection of the position of the second entity.
""" ;
  rdfs:subPropertyOf sio:is_connected_to ;
  a owl:FunctionalProperty .

sio:is_preceded_by a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_causally_related_to ;
  a owl:FunctionalProperty .

sio:is_prior_version_of a owl:ObjectProperty ;
  rdfs:comment "A is prior version of B iff A is a variant of B and B derives from A." ;
  rdfs:seeAlso sio:isDerivedFrom ;
  rdfs:subPropertyOf sio:is_version_of ;
  a owl:FunctionalProperty .

sio:is_product_of a owl:ObjectProperty ;
  rdfs:comment """is product of is a relation between an entity and a process, where the entity is present at the end  of the process as a result of a transformation in the process target.
""" ;
  rdfs:subPropertyOf sio:is_output_of ;
  a owl:FunctionalProperty .

sio:is_proper_part_of a owl:ObjectProperty ;
  rdfs:comment """is proper part of is an asymmetric, irreflexive (normally transitive) relation between a part and its distinct whole.
""" ;
  rdfs:subPropertyOf sio:is_part_of ;
  a owl:FunctionalProperty .

sio:is_property_of a owl:ObjectProperty ;
  rdfs:comment """is property of is a relation betweena  quality, capability or role and the entity that it and it alone bears.
""" ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_provider_of a owl:ObjectProperty ;
  rdfs:comment "is provider of is a relation between a source and the entity it makes available." ;
  rdfs:subPropertyOf sio:is_source_of ;
  a owl:FunctionalProperty .

sio:is_quality_of a owl:ObjectProperty ;
  rdfs:comment """is quality of is a relation between a quality and the entity that it is a property of.
""" ;
  rdfs:domain sio:Quality ;
  rdfs:subPropertyOf sio:is_property_of ;
  a owl:FunctionalProperty .

sio:is_realizable_property_of a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_property_of ;
  a owl:FunctionalProperty .

sio:is_realized_in a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_participant_in ;
  a owl:FunctionalProperty .

sio:is_referenced_by a owl:ObjectProperty ;
  rdfs:comment """is reference for is a relation between a document that provides information about an entity.
""" ;
  rdfs:subPropertyOf sio:is_referred_to_by ;
  a owl:FunctionalProperty .

sio:is_referred_to_by a owl:ObjectProperty ;
  rdfs:comment """A is referred to by B iff B is an informational entity that makes reference to A.
""" ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:is_refuted_by a owl:ObjectProperty ;
  rdfs:comment """has evidence is a relation between a proposition and something that refutes (is incompatible with) the truth of the assertion.
""" ;
  rdfs:subPropertyOf sio:has_evidence ;
  a owl:FunctionalProperty .

sio:is_refuting_evidence_for a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_evidence_for ;
  a owl:FunctionalProperty .

sio:is_regulated_by a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_causally_related_from ;
  a owl:FunctionalProperty .

sio:is_related_to a owl:ObjectProperty ;
  rdfs:comment "A is related to B iff there is some relation between A and B." ;
  skosvocab:editorialNote "'is related to' is the top level relation in SIO" ;
  rdfs:range sio:Entity ;
  rdfs:domain sio:Entity ;
  a owl:FunctionalProperty .

sio:is_represented_by a owl:ObjectProperty ;
  rdfs:comment "is represented by: a relation between an entity and some symbol." ;
  rdfs:subPropertyOf sio:is_referred_to_by ;
  a owl:FunctionalProperty .

sio:is_result_of a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_causally_related_from ;
  a owl:FunctionalProperty .

sio:is_role_of a owl:ObjectProperty ;
  rdfs:comment "is role of is a relation between a role and the entity that it is a property of." ;
  rdfs:domain sio:Role ;
  rdfs:subPropertyOf sio:is_realizable_property_of ;
  a owl:FunctionalProperty .

sio:is_satisfied_by a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_similar_to a owl:ObjectProperty ;
  rdfs:comment """is similar to is a relation between two entities that share one or more features.
""" ;
  rdfs:subPropertyOf sio:is_variant_of ;
  a owl:FunctionalProperty .

sio:is_source_of a owl:ObjectProperty ;
  rdfs:comment "is source of is a relation between a source of information about some entity." ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_spatiotemporally_related_to a owl:ObjectProperty ;
  rdfs:comment """A is spatiotemporally related to B iff A is in the spatial or temporal vicinity of B
""" ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:is_specialization_of a owl:ObjectProperty ;
  rdfs:comment """is specialization of is a relation between a more specific instance (in terms of spatial/temporal localization & other attributres) than the other.
""" ;
  rdfs:subPropertyOf sio:is_variant_of ;
  a owl:FunctionalProperty .

sio:is_specified_by a owl:ObjectProperty ;
  rdfs:comment """a relation between a product and the information content entity that specifies it.
""" ;
  rdfs:seeAlso sio:isCausallyRelatedWith ;
  rdfs:subPropertyOf sio:is_described_by ;
  a owl:FunctionalProperty .

sio:is_start_time_of a owl:ObjectProperty ;
  rdfs:domain sio:TimeInstant ;
  rdfs:subPropertyOf sio:is_time_boundary_of ;
  a owl:FunctionalProperty .

sio:is_subject_of a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_described_by ;
  a owl:FunctionalProperty .

sio:is_subsequent_version_of a owl:ObjectProperty ;
  rdfs:comment "A is subsequent version of B iff A is a variant of B and A derives from B." ;
  rdfs:subPropertyOf sio:is_version_of ;
  a owl:FunctionalProperty .

sio:is_supported_by a owl:ObjectProperty ;
  rdfs:comment """is supported by is a relation between a proposition and something that supports the truth of the assertion.
""" ;
  rdfs:subPropertyOf sio:has_evidence ;
  a owl:FunctionalProperty .

sio:is_supporting_evidence_for a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_evidence_for ;
  a owl:FunctionalProperty .

sio:is_surrounded_by a owl:ObjectProperty ;
  rdfs:comment """A 'is surrounded by' B iff the A 'is contained by' B and A 'is adjacent to' B or A 'is directly connected to' B.
""" ;
  rdfs:subPropertyOf sio:is_contained_in ;
  a owl:FunctionalProperty .

sio:is_target_in a owl:ObjectProperty ;
  rdfs:comment """is target in is a relation between an entity and a process, where the entity is present at the beginning  of the process and undergoes a change or transformation in the process.
""" ;
  rdfs:subPropertyOf sio:is_input_in ;
  a owl:FunctionalProperty .

sio:is_time_boundary_of a owl:ObjectProperty ;
  rdfs:domain sio:TimeInstant ;
  rdfs:subPropertyOf sio:is_boundary_of ;
  a owl:FunctionalProperty .

sio:is_transcribed_from a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_encoded_by ;
  a owl:FunctionalProperty .

sio:is_transcribed_into a owl:ObjectProperty ;
  rdfs:comment """a relation between two information content entities in which one is transcribed into (an exact or similar kind) another through some process.
""" ;
  rdfs:subPropertyOf sio:encodes ;
  a owl:FunctionalProperty .

sio:is_transformed_from a owl:ObjectProperty ;
  rdfs:comment """A transitive temporal relation in which an entity mainstains identity from one state to another.
""" ;
  rdfs:subPropertyOf sio:is_causally_related_from ;
  a owl:FunctionalProperty .

sio:is_translated_from a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_encoded_by ;
  a owl:FunctionalProperty .

sio:is_translated_into a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:encodes ;
  a owl:FunctionalProperty .

sio:is_trigger_for a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:is_causally_related_from ;
  a owl:FunctionalProperty .

sio:is_unique_identifier_for a owl:ObjectProperty ;
  rdfs:comment """is unique identifier for is a relation between an identifier and an entity that it uniquely identifies
""" ;
  rdfs:domain sio:UniqueIdentifier ;
  rdfs:subPropertyOf sio:is_identifier_for ;
  a owl:FunctionalProperty .

sio:is_unit_of a owl:ObjectProperty ;
  rdfs:comment "is unit of is a relation between a unit and a quantity that it is a multiple of." ;
  rdfs:domain sio:UnitOfMeasurement ;
  rdfs:subPropertyOf sio:is_attribute_of ;
  a owl:FunctionalProperty .

sio:is_variant_of a owl:ObjectProperty ;
  rdfs:comment """is variant of: a relationship indicating that two entities are different (by some measure), but either achieve the same objectives in different ways or are permutations of one another (temporal, logical or otherwise)
""" ;
  rdfs:subPropertyOf sio:is_comparable_to ;
  a owl:FunctionalProperty .

sio:is_version_of a owl:ObjectProperty ;
  rdfs:comment """is version of is a relation that holds between any two versions in which one is a subsequent or alternate version of (through a branch).
""" ;
  rdfs:subPropertyOf sio:is_variant_of ;
  a owl:FunctionalProperty .

sio:is_weakly_interacting_with a owl:ObjectProperty ;
  rdfs:seeAlso sio:isDirectlyConnectedTo ;
  rdfs:subPropertyOf sio:is_weakly_interacting_withtransitive ;
  a owl:FunctionalProperty .

sio:is_weakly_interacting_withtransitive a owl:ObjectProperty ;
  rdfs:comment """is weakly interacting with is a symmetric relation between two molecular entities (or any part thereof) that are interacting through some weak force (van der waals, hydrogen bonds, electrostatic interactions)
""" ;
  rdfs:subPropertyOf sio:is_connected_to ;
  a owl:FunctionalProperty .

sio:is_xenologous_to a owl:ObjectProperty ;
  rdfs:comment """a relation between two entities which indicates their common ancestry but due to horizontal gene transfer.
""" ;
  rdfs:subPropertyOf sio:is_orthologous_to ;
  a owl:FunctionalProperty .

sio:measured_at a owl:ObjectProperty ;
  rdfs:comment "measured at is a relation between a measurement value and the time measurement." ;
  rdfs:range sio:TimeMeasurement ;
  rdfs:subPropertyOf sio:exists_at ;
  a owl:FunctionalProperty .

sio:negatively_regulates a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:regulates ;
  a owl:FunctionalProperty .

sio:overlaps_with a owl:ObjectProperty ;
  rdfs:comment "A overlaps with B iff there is some C that is part of both A and B. [S][R]" ;
  rdfs:subPropertyOf sio:is_spatiotemporally_related_to ;
  a owl:FunctionalProperty .

sio:positively_regulates a owl:ObjectProperty ;
  rdfs:subPropertyOf sio:regulates ;
  a owl:FunctionalProperty .

sio:precedes a owl:ObjectProperty ;
  rdfs:comment """A transitive, temporal relation in which one process precedes (has occured earlier than) another process.
""" ;
  rdfs:subPropertyOf sio:is_causally_related_from ;
  a owl:FunctionalProperty .

sio:realizes a owl:ObjectProperty ;
  rdfs:comment """realizes is a relation between a process and a realizable entity (role, function, disposition).
""" ;
  rdfs:subPropertyOf sio:has_output ;
  a owl:FunctionalProperty .

sio:references a owl:ObjectProperty ;
  rdfs:comment """references is a relation between one entity and the entity that it makes reference to by name, but is not described by it.
""" ;
  rdfs:subPropertyOf sio:refers_to ;
  a owl:FunctionalProperty .

sio:refers_to a owl:ObjectProperty ;
  rdfs:comment """refers to is a relation between one entity and the entity that it makes reference to.
""" ;
  rdfs:subPropertyOf sio:is_related_to ;
  a owl:FunctionalProperty .

sio:regulates a owl:ObjectProperty ;
  rdfs:comment """x regulates y if and only if x is a process and y is either a process or a quality, and the progression of x exerts an effect on the frequency, rate or extent of y
""" ;
  rdfs:subPropertyOf sio:is_causally_related_to ;
  a owl:FunctionalProperty .

sio:represents a owl:ObjectProperty ;
  rdfs:comment "a represents b when a serves as a sign, symbol or model of b." ;
  rdfs:subPropertyOf sio:refers_to ;
  a owl:FunctionalProperty .

sio:results_in a owl:ObjectProperty ;
  rdfs:seeAlso sio:hasOutput ;
  rdfs:subPropertyOf sio:is_causally_related_to ;
  a owl:FunctionalProperty .

sio:satisfies a owl:ObjectProperty ;
  rdfs:comment """satisfies is a relation between an entity and the specification or objective that it conforms to.
""" ;
  rdfs:range sio:Description ;
  rdfs:domain sio:Entity ;
  rdfs:subPropertyOf sio:has_attribute ;
  a owl:FunctionalProperty .

sio:specifies a owl:ObjectProperty ;
  rdfs:comment """A relation between an information content entity and a product that it (directly/indirectly) specifies
""" ;
  rdfs:seeAlso sio:isCausallyRelatedWith ;
  rdfs:subPropertyOf sio:describes ;
  a owl:FunctionalProperty .

sio:surrounds a owl:ObjectProperty ;
  rdfs:comment """A 'surrounds' B iff the A 'contains' B and A 'is adjacent to' B or A 'is directly connected to' B.
""" ;
  rdfs:subPropertyOf sio:contains ;
  a owl:FunctionalProperty .

sio:transforms_into a owl:ObjectProperty ;
  rdfs:comment """A transitive temporal relation in which an entity mainstains identity from one state to another.
""" ;
  rdfs:subPropertyOf sio:is_causally_related_to ;
  a owl:FunctionalProperty .

dct:license a owl:AnnotationProperty .

pav:version a owl:AnnotationProperty .

vann:preferredNamespacePrefix a owl:AnnotationProperty .

vann:preferredNamespaceUri a owl:AnnotationProperty .

skosvocab:editorialNote a owl:AnnotationProperty .

sh:declare a owl:AnnotationProperty .

sh:prefix a owl:AnnotationProperty .

sh:namespace a owl:AnnotationProperty .
