PREFIX obo:
PREFIX rdf:
PREFIX rdfs:
PREFIX xsd:
obo:XCO_0001310 a rdfs:Class ;
rdfs:label "controlled methylprednisolone sodium succinate content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of methylprednisolone sodium succinate, the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0001309 .
obo:XCO_0000281 a rdfs:Class ;
rdfs:label "type II collagen" ;
rdfs:comment "A condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye. Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility." ;
rdfs:subClassOf obo:XCO_0000262 .
obo:XCO_0000518 a rdfs:Class ;
rdfs:label "anti-Shiga toxin 1 beta antibody" ;
rdfs:comment "A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0001442 a rdfs:Class ;
rdfs:label "experimental drill-hole bone defect sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental drill-hole bone defect sham procedure, which follows the same surgical process through full tissue thickness incision, but no bone defect is made." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:BFO_0000050 a rdf:Property ;
rdfs:label "part_of" ;
rdfs:range .
obo:XCO_0001323 a rdfs:Class ;
rdfs:label "experimental drill-hole bone defect" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental drill-hole bone defect, a controlled, precisely defined defect created with a surgical bone drill. This type of bone defect is made in laboratory animals to study the healing of bone fractures and sometimes for delivery of therapeutic substances." ;
rdfs:subClassOf obo:XCO_0001394 .
obo:XCO_0000981 a rdfs:Class ;
rdfs:label "controlled lithium chloride content gelled diet" ;
rdfs:comment "This is an experimental regimen of gelled food in which the amount of solid elements, water, and lithium chloride in the diet are controlled." ;
rdfs:subClassOf obo:XCO_0000980 .
obo:XCO_0000696 a rdfs:Class ;
rdfs:label "soluble guanylate cyclase stimulator" ;
rdfs:comment "An allosteric enzyme activator that increases guanylate cyclase activity only when the heme iron is in its reduced state (Fe2+)." ;
rdfs:subClassOf obo:XCO_0000694 .
obo:XCO_0000303 a rdfs:Class ;
rdfs:label "adrenalectomy" ;
rdfs:comment "The surgical excision of one or both of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0001260 a rdfs:Class ;
rdfs:label "sterile water, pH-adjusted" ;
rdfs:comment "This is any condition in which the main influencing factor is pH-adjusted sterile water, an acidity- or alkalinity-adjusted sterile water that is equilibrated to a specific pH." ;
rdfs:subClassOf obo:XCO_0001247 .
obo:XCO_0000299 a rdfs:Class ;
rdfs:label "controlled ethanol content drinking water with no other optional drink source" ;
rdfs:comment "Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied as the only available drink option for consumption by an organism in an experiment." ;
rdfs:subClassOf obo:XCO_0000023 .
obo:RO_0002180 a rdf:Property ;
rdfs:label "has_component" ;
rdfs:range .
obo:XCO_0000750 a rdfs:Class ;
rdfs:label "diclofenac" ;
rdfs:comment "This is any condition in which the main influencing factor is diclofenac, a monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. It is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000506 .
obo:XCO_0000681 a rdfs:Class ;
rdfs:label "Medica 16" ;
rdfs:comment "This is any condition in which the main influencing factor is Medica 16, an α,ω-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000523 , obo:XCO_0000680 .
obo:XCO_0000586 a rdfs:Class ;
rdfs:label "Gnai2 antisense oligonucleotide" ;
rdfs:subClassOf obo:XCO_0000234 .
obo:XCO_0000704 a rdfs:Class ;
rdfs:label "carotid artery occlusion" ;
rdfs:comment "A surgical manipulation causing blockage of one or both of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0001461 a rdfs:Class ;
rdfs:label "controlled glycerol content saline" ;
rdfs:comment "This is any condition in which the main influencing factor is a specific amount of glycerol dissolved in saline (0.9% sodium chloride solution). Glycerol is a trihydroxy sugar alcohol that is used as a solvent, emollient, pharmaceutical agent, and sweetening agent." ;
rdfs:subClassOf obo:XCO_0000156 .
obo:XCO_0000102 a rdfs:Class ;
rdfs:label "fasting" ;
rdfs:comment "Abstaining from the consumption of food, often for a specified period of time." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0001293 a rdfs:Class ;
rdfs:label "PM2.5" ;
rdfs:comment "This is any condition in which the main influencing factor is PM2.5, which is particulate matter consisting of fine inhalable particles, with diameters that are generally 2.5 micrometers and smaller." ;
rdfs:subClassOf obo:XCO_0001291 .
obo:XCO_0001132 a rdfs:Class ;
rdfs:label "sesame oil" ;
rdfs:comment "This is any condition in which the main influencing factor is sesame oil, an edible vegetable oil derived from sesame seeds. Sesame oil can be used as a solvent for an injected drug or an intravenous drip." ;
rdfs:subClassOf obo:XCO_0000774 .
obo:XCO_0000367 a rdfs:Class ;
rdfs:label "surgical device implantation sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical control device implantation in which the control device does not dispense the chemical, drug, or electrical stimulation dispensed by the experimental device." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000142 a rdfs:Class ;
rdfs:label "sodium nitroprusside" ;
rdfs:comment "This is any condition in which the main influencing factor is sodium nitroprusside, the red-colored inorganic salt with the formula Na2[Fe(CN)5NO]?2H2O used as a potent vasodilator." ;
rdfs:subClassOf obo:XCO_0000140 .
obo:XCO_0000865 a rdfs:Class ;
rdfs:label "dehydroepiandrosterone" ;
rdfs:comment "A condition in which the main influencing factor is an androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0001175 a rdfs:Class ;
rdfs:label "acetone" ;
rdfs:comment "This is any condition in which the main influencing factor is acetone, a methyl ketone that consists of propane bearing an oxo group at C2. Acetone is used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis. Acetone is used to make drugs and other chemicals." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000634 a rdfs:Class ;
rdfs:label "antidiuretic" ;
rdfs:comment "This is a condition in which the main influencing factor is an antidiuretic, a substance that helps to control fluid balance in an animal's body by reducing urination, opposing diuresis. Its effects are opposite that of a diuretic." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0000541 a rdfs:Class ;
rdfs:label "bosentan" ;
rdfs:comment "An experimental condition in which the main influencing factor is bosentan, a competitive antagonist of endothelin-1 that blocks the binding of endothelin to both the endothelin-A (ET-A) and endothelin-B (ET-B)receptors. Bosentan is used in the treatment of pulmonary arterial hypertension." ;
rdfs:subClassOf obo:XCO_0000730 .
obo:XCO_0000061 a rdfs:Class ;
rdfs:label "serial subtraction exercise" ;
rdfs:comment "An activity in which a person starts with a number and deducts a specified number from that and then deducts the same number from the remainder of the first computation, without using a calculator or pencil and paper." ;
rdfs:subClassOf obo:XCO_0000060 .
obo:XCO_0001396 a rdfs:Class ;
rdfs:label "transfer of circNrxn3 siRNA using jetPEI transfection reagent" ;
rdfs:comment "This is any condition in which the main influencing factor is circNrxn3 (a circular RNA originating from the neurexin 3 gene) siRNA transfected by jetPEI transfection reagent. JetPEI transfection reagent is a linear polyethylenimine derivative, designed for high throughput screening (HTS) in adherent and suspension cell cultures." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0001294 a rdfs:Class ;
rdfs:label "PM10" ;
rdfs:comment "This is any condition in which the main influencing factor is PM10, which is particulate matter consisting of inhalable particles, with diameters that are generally 10 micrometers and smaller." ;
rdfs:subClassOf obo:XCO_0001291 .
obo:XCO_0001701 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to collapsin response mediator protein 2 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to an autoantibody-generating level of collapsin response mediator protein 2 (CRMP2) multiple antigenic peptides (MAPs). This is a condition typically studied to determine the effect of maternal (F0) collapsin response mediator protein 2 exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001702 .
obo:XCO_0000398 a rdfs:Class ;
rdfs:label "cisplatin" ;
rdfs:comment "A condition in which the main influencing factor is cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion. Cisplatin is mutagenic and serves as an anti-cancer drug through its ability to bind to and crosslink DNA, interfering with cell division, triggering DNA repair mechanisms and, in turn, activating apoptosis." ;
rdfs:subClassOf obo:XCO_0000205 , obo:XCO_0000399 , obo:XCO_0000435 .
obo:XCO_0001818 a rdfs:Class ;
rdfs:label "nucleic acid transfer" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of exogenous DNA or RNA sequences which have been transiently or stably inserted into a living cell or organism in order to promote or block synthesis of specific gene product(s)." ;
rdfs:subClassOf obo:XCO_0000527 .
obo:XCO_0001512 a rdfs:Class ;
rdfs:label "transfer of negative control shRNA using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of negative control shRNA (short hairpin RNA) delivered with an adenovirus vector. Negative control shRNA is an shRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental shRNA used." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0000403 a rdfs:Class ;
rdfs:label "controlled cisplatin content diet" ;
rdfs:comment "A solid diet in which the amount of cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000138 a rdfs:Class ;
rdfs:label "methylene blue" ;
rdfs:comment "Methylene blue is monoamine oxidase inhibitor and nitric oxide synthase inhibitor, as well as a cationic dye used as a redox indicator." ;
rdfs:subClassOf obo:XCO_0000199 , obo:XCO_0000523 .
obo:XCO_0001214 a rdfs:Class ;
rdfs:label "reverse osmosis-filtered water" ;
rdfs:comment "This is any condition in which the main influencing factor is reverse osmosis-filtered water, purified water that has sediment and chlorine removed from it with a prefilter before solutes are removed by a semipermeable membrane. Reverse osmosis-filtered water also passes through a postfilter after the semi-permeable membrane." ;
rdfs:subClassOf obo:XCO_0000021 .
obo:XCO_0001411 a rdfs:Class ;
rdfs:label "CTS scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a porous chitosan (CTS) scaffold, a tissue scaffold made of macroporous chitosan hydrogel. Chitosan is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine. Chitosan is attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblasts as well as formation of mineralized bone matrix." ;
rdfs:subClassOf obo:XCO_0001439 .
obo:XCO_0000581 a rdfs:Class ;
rdfs:label "oral gavage" ;
rdfs:comment "This is any condition in which the main influencing factor is the introduction of material, food, or drug into the stomach by a tube via the oral cavity." ;
rdfs:subClassOf obo:XCO_0000580 .
obo:XCO_0001679 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to limited bedding and nesting" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to limited bedding and nesting that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) limited bedding and nesting use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001087 .
obo:XCO_0001337 a rdfs:Class ;
rdfs:label "controlled enrofloxacin content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of enrofloxacin, in which the amount of enrofloxacin consumed is maintained at a specified level. Enrofloxacin is an antibiotic and antineoplastic agent from the fluoroquinolone family used in veterinary medicine." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000259 a rdfs:Class ;
rdfs:label "disease-inducing chemical" ;
rdfs:comment "A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs." ;
rdfs:subClassOf obo:XCO_0000258 , obo:XCO_0000341 .
obo:XCO_0000880 a rdfs:Class ;
rdfs:label "mifepristone" ;
rdfs:comment "Any condition in which the main influencing factor is mifepristone, a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary Cushing Syndrome." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0001739 a rdfs:Class ;
rdfs:label "dicyclohexyl phthalate" ;
rdfs:comment "This is any condition in which the main influencing factor is dicyclohexyl phthalate,a phthalate ester. Phthalate esters are esters of phthalic acid and are mainly used as plasticizers and found in many commercial products. Phthalates are hazardous due to their ability to act as endocrine disruptors." ;
rdfs:subClassOf obo:XCO_0000511 .
obo:XCO_0000317 a rdfs:Class ;
rdfs:label "buffered calcium ion solution" ;
rdfs:comment "A homogeneous mixture of calcium, the chemical element with atomic number 20, with other molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000185 , obo:XCO_0000315 .
obo:XCO_0000178 a rdfs:Class ;
rdfs:label "thapsigargin" ;
rdfs:comment "A non-competitive inhibitor of the sarco / endoplasmic reticulum Ca2+ ATPase (SERCA) class of enzymes. Acts as a non-phorbol-ester-type tumor promoter and acts as an inhibitor of calcium ATPase of endoplasmic reticulum, leading to an increase in cytoplasmic calcium ions." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0000892 .
obo:XCO_0000898 a rdfs:Class ;
rdfs:label "minoxidil" ;
rdfs:comment "This a pyrimidine N-oxide that is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure." ;
rdfs:subClassOf obo:XCO_0000140 .
obo:XCO_0001222 a rdfs:Class ;
rdfs:label "ritonavir" ;
rdfs:comment "This is any condition in which the main influencing factor is ritonavir, a CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS. Ritonavir is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Ritonavir is also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir for treatment of chronic hepatitis C virus genotype 1 infection and cirrhosis of the liver." ;
rdfs:subClassOf obo:XCO_0000657 , obo:XCO_0000748 .
obo:XCO_0000619 a rdfs:Class ;
rdfs:label "digoxin" ;
rdfs:comment "A cardenolide glycoside that is digitoxin β-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small." ;
rdfs:subClassOf obo:XCO_0000139 .
obo:XCO_0001400 a rdfs:Class ;
rdfs:label "desflurane" ;
rdfs:comment "This is any condition in which the main influencing factor is desflurane, an organofluorine compound that is an inhalation anaesthetic functionally related to methoxyethane." ;
rdfs:subClassOf obo:XCO_0000106 .
obo:XCO_0000738 a rdfs:Class ;
rdfs:label "lipopolysaccharide" ;
rdfs:comment "This is any condition in which the main influencing factor is lipopolysaccharide, the most common type of endotoxin, found in the outer membrane of gram-negative bacteria. Lipopolysaccharide consists of the lipid A portion containing fatty acids and disaccharide phosphates, core polysaccharides, and the O-antigen (repetitive glycan polymer)." ;
rdfs:subClassOf obo:XCO_0000737 .
obo:XCO_0000297 a rdfs:Class ;
rdfs:label "fluid deprivation" ;
rdfs:comment "Condition in which liquids for drinking (bringing a liquid into the mouth and swallowing it to quench thirst, for nourishment, etc.), such as water, are withheld for a specified period of time." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0001587 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to ITE" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to ITE (2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester) that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) ITE use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001586 .
obo:XCO_0000113 a rdfs:Class ;
rdfs:label "right nephrectomy" ;
rdfs:comment "Surgical removal of the right kidney." ;
rdfs:subClassOf obo:XCO_0000112 .
obo:XCO_0001207 a rdfs:Class ;
rdfs:label "propranolol" ;
rdfs:comment "This is any condition in which the main influencing factor is propranolol, a widely used non-cardioselective beta-adrenergic antagonist. Propranolol functions as an anxiolytic drug, an anti-arrhythmia drug, a vasodilator agent, and an antihypertensive agent." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000336 , obo:XCO_0000863 , obo:XCO_0001122 .
obo:XCO_0000822 a rdfs:Class ;
rdfs:label "JTE-607" ;
rdfs:comment "JTE-607 is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3). JTE-607 reduces the production of proinflammatory cytokines in models of acute injury, septic shock and endotoxemia." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000505 .
obo:XCO_0001732 a rdfs:Class ;
rdfs:label "gestational maternal exposure to gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector. This is a condition typically studied to determine the effect of a maternal (F0) exposure to gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001731 .
obo:XCO_0000775 a rdfs:Class ;
rdfs:label "soybean oil" ;
rdfs:comment "Any condition in which the main influencing factor is soybean oil. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols." ;
rdfs:subClassOf obo:XCO_0000774 .
obo:XCO_0000072 a rdfs:Class ;
rdfs:label "wine" ;
rdfs:comment "Alcoholic drink made by fermenting the juice of grapes." ;
rdfs:subClassOf obo:XCO_0000070 .
obo:XCO_0001326 a rdfs:Class ;
rdfs:label "left anterior descending coronary artery occlusion sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a left anterior descending coronary artery occlusion sham procedure, which follows the same surgical process as an left anterior descending coronary artery occlusion without blocking the left anterior descending coronary artery." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000577 a rdfs:Class ;
rdfs:label "proton pump inhibitor" ;
rdfs:comment "Proton pump inhibitors (PPIs) reduce the production of acid by blocking H+/K+ ATPase in the wall of the stomach." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0000131 a rdfs:Class ;
rdfs:label "xylazine" ;
rdfs:comment "An alpha2-adrenergic receptor agonist used for sedation, anesthesia, muscle relaxation, and analgesia in animals." ;
rdfs:subClassOf obo:XCO_0000106 .
obo:XCO_0001236 a rdfs:Class ;
rdfs:label "Morinda officinalis polysaccharide" ;
rdfs:comment "This is any condition whose main influencing factor is Morinda officinalis polysaccharide, a crude polysaccharide extract from the root of Morinda officinalis, a plant used in traditional Chinese medicine." ;
rdfs:subClassOf obo:XCO_0000173 .
obo:XCO_0000372 a rdfs:Class ;
rdfs:label "dexamethasone" ;
rdfs:comment "A condition in which the main influencing factor is dexamethasone, a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities." ;
rdfs:subClassOf obo:XCO_0000091 , obo:XCO_0000505 , obo:XCO_0000636 .
obo:XCO_0000378 a rdfs:Class ;
rdfs:label "vitamin E" ;
rdfs:comment "A condition in which the main influencing factor is any of a group of at least eight related fat-soluble compounds with similar biological antioxidant activity, particularly alpha-tocopherol but also including other isomers of tocopherol and the related compounds tocotrienol and tocomonoenol." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000377 .
obo:XCO_0001751 a rdfs:Class ;
rdfs:label "gestational maternal exposure to nicotine" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to nicotine. This is a condition typically studied to determine the effect of maternal (F0) nicotine use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001750 .
obo:XCO_0001517 a rdfs:Class ;
rdfs:label "gestational maternal exposure to poly I:C" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to poly I:C. This is a condition typically studied to determine the effect of maternal (F0) poly I:C use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001516 .
obo:XCO_0001593 a rdfs:Class ;
rdfs:label "human iPS cell-derived hNS/PCs" ;
rdfs:comment "This is any condition in which the main influencing factor is an injection or infusion of human neural stem/progenitor cells (hNS/PCs) derived from human induced pluripotent stem cells." ;
rdfs:subClassOf obo:XCO_0001032 .
obo:XCO_0000992 a rdfs:Class ;
rdfs:label "B-27" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is B-27, an optimized serum-free supplement used to support the low- or high-density growth and short- or long-term viability of embryonic, post-natal, and adult hippocampal and other CNS neurons. It is meant to supplement a basal medium such as Neurobasal medium." .
obo:XCO_0001225 a rdfs:Class ;
rdfs:label "sumatriptan" ;
rdfs:comment "This is any condition in which the main influencing factor is sumatriptan, a serotonin agonist that acts selectively at 5HT1 receptors. It i s used for the acute treatment of migraine with or without aura in adults." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000141 .
obo:XCO_0001433 a rdfs:Class ;
rdfs:label "canagliflozin" ;
rdfs:comment "This is any condition in which the main influencing factor is canagliflozin, a glucoside-derived sodium/glucose cotransporter (Slc5a2) inhibitor used clinically to treat type 2 diabetes mellitus." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000407 .
obo:XCO_0001164 a rdfs:Class ;
rdfs:label "labetalol" ;
rdfs:comment "This is any condition whose main influencing factor is labetalol, a salicylamide derivative that is a non-cardioselective blocker of beta-adrenergic receptors and alpha-1 adrenergic receptors used to treat high blood pressure." ;
rdfs:subClassOf obo:XCO_0000336 .
obo:XCO_0001706 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to stress induced phosphoprotein 1 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to an autoantibody-generating level of stress induced phosphoprotein 1 (STIP1) multiple antigenic peptides (MAPs). This is a condition typically studied to determine the effect of maternal (F0) STIP1 exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001705 .
obo:XCO_0000286 a rdfs:Class ;
rdfs:label "retinal S-antigen" ;
rdfs:comment "A condition in which the major influencing factor is a highly antigenic, soluble photoreceptor protein expressed in the retina and the pineal gland and involved in desensitization of the photoactivated transduction cascade." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000490 a rdfs:Class ;
rdfs:label "ongoing social environment condition" ;
rdfs:comment "Any condition in which the social environment of an organism is set or changed for an extended period of time or on a continual basis." ;
rdfs:subClassOf obo:XCO_0000488 .
obo:XCO_0000716 a rdfs:Class ;
rdfs:label "controlled SB-239063 content diet" ;
rdfs:comment "A regimen of solid food in which the amount of SB-239063 consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001283 a rdfs:Class ;
rdfs:label "grouped housing" ;
rdfs:comment "This is any condition in which the main influencing factor is grouped housing, a living situation involving four or more individual subjects housed in the same structure." ;
rdfs:subClassOf obo:XCO_0000033 .
obo:XCO_0001147 a rdfs:Class ;
rdfs:label "clofibrate" ;
rdfs:comment "This is any condition whose main influencing factor is clofibrate, a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia." ;
rdfs:subClassOf obo:XCO_0000680 .
obo:XCO_0000063 a rdfs:Class ;
rdfs:label "cycling, stationary" ;
rdfs:comment "The act of propelling the wheel or wheels of a fixed exercise machine through the action of one's legs." ;
rdfs:subClassOf obo:XCO_0000062 .
obo:XCO_0000544 a rdfs:Class ;
rdfs:label "vitamin D2" ;
rdfs:comment "An experimental condition in which the main influencing factor is vitamin D2, a type of vitamin D found in food and used as a dietary supplement. The D2 vitamer has been found to be less efficiently absorbed in the human intestine and/or less biologically active than the D3 vitamer." ;
rdfs:subClassOf obo:XCO_0000543 .
obo:XCO_0000443 a rdfs:Class ;
rdfs:label "controlled dexamethasone content diet" ;
rdfs:comment "A solid diet in which the amount of dexamethasone (DEX) is maintained at a specified level. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000806 a rdfs:Class ;
rdfs:label "selective retinal therapy" ;
rdfs:comment "Selective retinal therapy (SRT) is a subthreshold laser therapy used to treat retinal disorders while preventing severe damage to the retina. In SRT RPE (retinal pigment epithelium) cells are selectively damaged without affecting the photoreceptors or choroid by using laser pulse durations of microseconds or nanoseconds" ;
rdfs:subClassOf obo:XCO_0000803 .
obo:XCO_0001334 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to oxycodone" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to oxycodone that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) oxycodone use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001330 .
obo:XCO_0001867 a rdfs:Class ;
rdfs:label "controlled cholic acid content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a solid diet in which the amount of cholic acid is maintained at a specified level. Cholic acid is a bile acid that facilitates fat absorption and cholesterol excretion." ;
rdfs:subClassOf obo:XCO_0000394 , obo:XCO_0001866 .
obo:XCO_0001453 a rdfs:Class ;
rdfs:label "gene transfer of the VEGFC gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the vascular endothelial growth factor C gene (VEGFC) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000812 a rdfs:Class ;
rdfs:label "controlled hemorrhage" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled hemorrhage, the drawing of blood (by venipuncture or artery puncture) for transfusion, apheresis, diagnostic testing, or experimental procedures." ;
rdfs:subClassOf obo:XCO_0000595 .
obo:XCO_0001426 a rdfs:Class ;
rdfs:label "albiflorin" ;
rdfs:comment "This is any condition in which the main influencing factor is albiflorin, a monoterpene glycoside with formula C23H28O11. Albiflorin is a plant metabolite found in various types of Peonies." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0000561 .
obo:XCO_0000732 a rdfs:Class ;
rdfs:label "CC531 cells" ;
rdfs:comment "A condition in which the main influencing factor is CC531, a rat colonic adenocarcinoma cell line used to study metastasis." ;
rdfs:subClassOf obo:XCO_0000709 .
obo:XCO_0000094 a rdfs:Class ;
rdfs:label "ovariectomy" ;
rdfs:comment "The removal of one or both ovaries, the female gonads, from an organism." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0001158 a rdfs:Class ;
rdfs:label "ethambutol" ;
rdfs:comment "This is any condition whose main influencing factor is ethambutol, an ethylenediamine derivative that is an antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0000753 a rdfs:Class ;
rdfs:label "left carotid artery occlusion" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical manipulation and left common carotid artery ligation to achieve partial or total blockage of blood flow from the left common carotid artery, or a branch (internal or external) of the left common carotid artery. The left common carotid artery may be clamped or tied with a suture(s) to achieve blockage of blood flow." ;
rdfs:subClassOf obo:XCO_0000751 .
obo:XCO_0000855 a rdfs:Class ;
rdfs:label "rat serum from subject bearing a non-specified IgE-producing hybridoma" ;
rdfs:comment "Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected non-specified IgE-producing hybridoma. The serum is essentially antiserum containing control IgE, which are directed against an unspecified antigen." ;
rdfs:subClassOf obo:XCO_0000769 .
obo:XCO_0001348 a rdfs:Class ;
rdfs:label "controlled Compound 1 content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled Compound 1 content diet, a regimen of solid food in which the amount of Compound 1 consumed is controlled. Coumpound 1 is a soluble guanylate cyclase activator." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001240 a rdfs:Class ;
rdfs:label "afatinib" ;
rdfs:comment "This is any condition in which the main influencing factor is afatinib, an inhibitor of epidermal growth factor receptor (EGFR, ERBB2, ERBB3, ERBB4) tyrosine kinases used for the treatment of metastatic non-small cell lung cancer." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000970 .
obo:XCO_0001121 a rdfs:Class ;
rdfs:label "PEG 400" ;
rdfs:comment "This is any condition in which the main influencing factor is polyethylene glycol 400, a polymer composed of repeating ethyleneoxy units with an average molecular weight of 400. PEG 400 is a clear, colorless, liquid with low toxicity, affording wide use in a variety of pharmaceutical formulations." ;
rdfs:subClassOf obo:XCO_0000926 .
obo:XCO_0001450 a rdfs:Class ;
rdfs:label "thioacetamide" ;
rdfs:comment "This is any condition in which the main influencing factor is thioacetamide, a thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur. Thioacetamide is used to replicate the initiation and progression of human liver disease in laboratory rats." ;
rdfs:subClassOf obo:XCO_0001449 .
obo:XCO_0001635 a rdfs:Class ;
rdfs:label "ginsenoside C-K" ;
rdfs:comment "This is any condition in which the main influencing factor is ginsenoside C-K, a ginsenoside found in Panax species that has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent. Ginsenoside C-K is also a beta-D-glucoside, a 12beta-hydroxy steroid, a tetracyclic triterpenoid, a 3beta-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid." ;
rdfs:subClassOf obo:XCO_0000091 , obo:XCO_0000435 , obo:XCO_0000505 .
obo:XCO_0001542 a rdfs:Class ;
rdfs:label "oxytocin" ;
rdfs:comment "This is any condition in which the main influencing factor is oxytocin, a peptide hormone (CYIQNCPLG) that is released from the posterior pituitary gland as a uterine-contracting and milk-ejecting hormone acting on smooth muscle cells. Oxytocin is also a neurotransmitter in the brain." ;
rdfs:subClassOf obo:XCO_0000228 .
obo:XCO_0000389 a rdfs:Class ;
rdfs:label "controlled cigarette smoke content" ;
rdfs:comment "A condition in which the air surrounding an organism or breathed by the organism contains a controlled amount of cigarette smoke, the combined gases and particulates given off when tobacco in the form of a cigarette burns or smolders. A cigarette is a cylinder of cut blonde or black tobacco ensheathed in a tube of paper, with or without an incorporated filter to decrease inhaled tars." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0001099 a rdfs:Class ;
rdfs:label "controlled air crystalline silica content" ;
rdfs:comment "This is any condition in which the main influencing factor is respirable crystalline silica, which is breathable silica dust. The level of crystalline silica in the air surrounding an organism or breathed by an organism is determined by environmental conditions, work conditions, or controlled as part of an experiment." ;
rdfs:subClassOf obo:XCO_0000009 , obo:XCO_0001098 .
obo:XCO_0000264 a rdfs:Class ;
rdfs:label "Freund's adjuvant" ;
rdfs:comment "A nonspecific stimulator of the immune response consisting of non-metabolizable oils used to make water-in-oil emulsions with specific antigens. The adjuvant increases the strength of the immune response." ;
rdfs:subClassOf obo:XCO_0000133 .
obo:XCO_0001233 a rdfs:Class ;
rdfs:label "telcagepant" ;
rdfs:comment "This is any condition in which the main influencing factor is telcagepant, a calcitonin gene-related peptide (CGRP) receptor antagonist which was an investigational drug for the acute treatment and prevention of migraine. Development of telcagepant was discontinued due to hepatic side effects." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000328 a rdfs:Class ;
rdfs:label "controlled deoxycorticosterone content drinking water" ;
rdfs:comment "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000983 a rdfs:Class ;
rdfs:label "gene transfer of the EGFP gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the enhanced green fluorescent protein (EGFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EGFP in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0001791 a rdfs:Class ;
rdfs:label "Saccharomyces cerevisiae strain GY007" ;
rdfs:comment "This is any condition in which the main influencing factor is Saccharomyces cerevisiae strain GY007, a strain of baker's yeast selected for its ability to metabolize galactose efficiently despite the presence of glucose. It is a potential therapeutic agent for classic galactosemia." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001772 a rdfs:Class ;
rdfs:label "carbon black nanoparticle" ;
rdfs:comment "This is any condition in which the main influencing factor is a carbon black nanoparticle with a size between 1 and 100 nanometers composed of carbon black. Carbon black is an elemental carbon in the form of virtually pure colloidal particles that are produced by incomplete combustion or thermal decomposition of gaseous or liquid hydrocarbons under controlled conditions." ;
rdfs:subClassOf obo:XCO_0000338 .
obo:XCO_0001598 a rdfs:Class ;
rdfs:label "gestational maternal exposure to valproate" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to valproate. This is a condition typically studied to determine the effect of maternal (F0) valproate use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001597 .
obo:XCO_0000349 a rdfs:Class ;
rdfs:label "arthritis-inducing agent" ;
rdfs:comment "Any phenomenon, chemical or biologic substance, or organism that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones." ;
rdfs:subClassOf obo:XCO_0000258 .
obo:XCO_0000052 a rdfs:Class ;
rdfs:label "tactile stimulus" ;
rdfs:comment "Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of touch, that is, the physiological sense by which external objects or forces are perceived through contact with the body. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." ;
rdfs:subClassOf obo:XCO_0000047 .
obo:XCO_0000124 a rdfs:Class ;
rdfs:label "furosemide" ;
rdfs:comment "This is any condition whose main influencing factor is furosemide, a diuretic drug which inhibits Nkcc2 (Slc12a1), one of the Na-K symporters and reduces the reabsorption of sodium chloride. Furosemide is used experimentally for sodium depletion." ;
rdfs:subClassOf obo:XCO_0000122 , obo:XCO_0000123 .
obo:XCO_0001841 a rdfs:Class ;
rdfs:label "neferine" ;
rdfs:comment "This is any condition in which the main influencing factor is neferine, an alkaloid derived from the green embryos of lotus seeds (Nelumbo nucifera Gaertn). It is a compound used in traditional Chinese medicine that exhibits antihypertensive effects." ;
rdfs:subClassOf obo:XCO_0000863 , obo:XCO_0001623 .
obo:XCO_0001501 a rdfs:Class ;
rdfs:label "phosphate ion" ;
rdfs:comment "This is any condition in which the main influencing factor is phosphate ion ([PO4]3−), a molecular species derived from phosphoric acid by the removal of three protons." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0000994 a rdfs:Class ;
rdfs:label "StemPro NSC SFM" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is StemPro NSC SFM, a serum-free culture medium formulated to meet the special requirements of neuronal stem cells. This medium supports expansion of both adherent and spheroid cultures, and differentiation capability into astrocytes, oligodendrocytes and neurons." ;
rdfs:subClassOf obo:XCO_0000966 .
obo:XCO_0000015 a rdfs:Class ;
rdfs:label "controlled calorie content diet" ;
rdfs:comment "A regimen of solid food in which the number of calories consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000338 a rdfs:Class ;
rdfs:label "chemical nanoparticle" ;
rdfs:comment "This is any condition in which the main influencing factor is a particle with a size between 1 and 100 nanometers composed of any substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001668 a rdfs:Class ;
rdfs:label "operant conditioning in a skinner box" ;
rdfs:comment "This is a condition in which the main influencing factor is operant conditioning in a Skinner box, a learning process in which voluntary behaviors are modified by association with the addition (or removal) of reward or aversive stimuli while the subject is in an operant conditioning chamber. The frequency or duration of the behavior may increase through reinforcement or decrease through punishment or extinction." ;
rdfs:subClassOf obo:XCO_0000001 .
obo:XCO_0000355 a rdfs:Class ;
rdfs:label "controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water" ;
rdfs:comment "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). MNNG is a guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000559 a rdfs:Class ;
rdfs:label "melatonin" ;
rdfs:comment "A biogenic amine that is found in animals and plants. In mammals, melatonin is a hormone produced by the pineal gland. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of sleep, mood, and reproduction. Melatonin is also an effective antioxidant." ;
rdfs:subClassOf obo:XCO_0000125 , obo:XCO_0000271 .
obo:XCO_0000055 a rdfs:Class ;
rdfs:label "tactile electric shock exposure" ;
rdfs:comment "This is any condition in which the main influencing factor is the stimulation of nerves involved in the physiological sense by which external objects or forces are perceived through contact with the body via application of an electric current." ;
rdfs:subClassOf obo:XCO_0000052 .
obo:XCO_0000306 a rdfs:Class ;
rdfs:label "cold exposure" ;
rdfs:comment "An activity or condition which involves subjecting all or part of an organism to a relatively low, i.e., lower than considered normal, temperature." ;
rdfs:subClassOf obo:XCO_0000111 .
obo:XCO_0001582 a rdfs:Class ;
rdfs:label "chlorogenic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is chlorogenic acid, a cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is an investigational drug for its anti-inflammatory, anti-cancer, anti-diabetic, and other medicinal properties." ;
rdfs:subClassOf obo:XCO_0000505 , obo:XCO_0000511 .
obo:XCO_0001127 a rdfs:Class ;
rdfs:label "Buyang Huanwu decoction" ;
rdfs:comment "This is any condition in which the main influencing factor is BHD (Buyang Huanwu Decoction), a multi-herbal composition (classic traditional chinese medicine formula) commonly prescribed in the treatment of cerebrovascular diseases." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0001409 a rdfs:Class ;
rdfs:label "tissue engineering scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of an engineered tissue scaffold, an artificial construct which mimics the extracellular matrix of the host tissue. The scaffold may be made of natural or synthetic polymers, metal, or ceramic." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0000077 a rdfs:Class ;
rdfs:label "tobacco use" ;
rdfs:comment "The use of any product made for human consumption from Nicotiana tabacum." ;
rdfs:subClassOf obo:XCO_0001365 .
obo:XCO_0001571 a rdfs:Class ;
rdfs:label "gestational maternal exposure to controlled air E-cigarette aerosol content" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to controlled air E-cigarette/nicotine aerosol content. This is a condition typically studied to determine the effect of maternal (F0) controlled air E-cigarette/nicotine (~2.4%) content exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001570 .
obo:XCO_0001404 a rdfs:Class ;
rdfs:label "42% O2, 58% N2" ;
rdfs:comment "This is a condition in which the level of oxygen (42%) and nitrogen (58%) in the air surrounding the organism or breathed by the organism is controlled as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000010 , obo:XCO_0001403 .
obo:XCO_0001762 a rdfs:Class ;
rdfs:label "experimental carotid intima injury" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental carotid balloon angioplasty, mechanically damaging the intima of the carotid artery(ies) by use of a soft catheter with an inflatable tip. The procedure involves surgically exposing the carotid artery(ies) and its lumen, followed by insertion of the inflatable catheter tip." .
obo:XCO_0001855 a rdfs:Class ;
rdfs:label "gestational maternal exposure to liquid diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to a liquid diet. This is a condition typically studied to determine the effect of a maternal (F0) liquid diet on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001854 .
obo:XCO_0001314 a rdfs:Class ;
rdfs:label "forced activity in rotating cylinder" ;
rdfs:comment "This is any condition in which the main influencing factor is forced activity in rotating cylinder, which can be used with rodents as a model of human shift work. The rotating cylinder (~1 revolution per 3 minutes) forces the subject to move and reposition repeatedly during a specified period." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0001211 a rdfs:Class ;
rdfs:label "Parabacteroides distasonis" ;
rdfs:comment "This is any condition in which the main influencing factor is Parabacteroides distasonis, an anaerobic, gram-negative bacillus of the CFB group of bacteria. P. distasonis is an aerotolerant anaerobe found in the gastrointestinal tract of numerous species." ;
rdfs:subClassOf obo:XCO_0001212 .
obo:XCO_0000048 a rdfs:Class ;
rdfs:label "auditory stimulus" ;
rdfs:comment "Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of hearing. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." ;
rdfs:subClassOf obo:XCO_0000047 .
obo:XCO_0001576 a rdfs:Class ;
rdfs:label "gene transfer of the human A53T α-synuclein gene using an AAV1/2 hybrid virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of the human A53T α-synuclein gene using an AAV1/2 hybrid virus vector. A53T α-synuclein is a mutant form of the human synuclein alpha (SNCA) gene." ;
rdfs:subClassOf obo:XCO_0001575 .
obo:XCO_0000761 a rdfs:Class ;
rdfs:label "biologics and probiotics" ;
rdfs:comment "This is any condition in which the main influencing factor is a biologic (product of, or component of, a living organism) or probiotic introduced externally or internally to a subject to effect a change in phenotype of the subject, usually in treatment of a medical condition. Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body." ;
rdfs:subClassOf obo:XCO_0000850 .
obo:XCO_0001170 a rdfs:Class ;
rdfs:label "obsolete levofloxacin" ;
rdfs:comment "OBSOLETE. This is any condition whose main influencing factor is levofloxacin, a fluoroquinolone antibiotic with activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin is an inhibitor of bacterial topoisomerase IV and DNA gyrase." .
obo:XCO_0000705 a rdfs:Class ;
rdfs:label "organic radical" ;
rdfs:comment "Neutral organic radicals are subvalent molecules, i.e., they have unpaired electrons, and, as such, they are typically highly reactive, transient species with short lifetimes that tend to dimerize, disproportionate, or react with oxygen." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000334 a rdfs:Class ;
rdfs:label "left adrenalectomy" ;
rdfs:comment "The surgical excision of only the adrenal gland on the left side of the body. The left adrenal gland is generally the larger of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." ;
rdfs:subClassOf obo:XCO_0000305 .
obo:XCO_0000292 a rdfs:Class ;
rdfs:label "peripheral nerve myelin" ;
rdfs:comment "A condition in which the major influencing factor is peripheral nerve myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the axons of peripheral nerves, that is, nerves that are not part of either the brain or spinal cord of the organism." ;
rdfs:subClassOf obo:XCO_0000352 .
obo:XCO_0000742 a rdfs:Class ;
rdfs:label "housing with Haemophilus-infected subject" ;
rdfs:comment "A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus infection during the time period leading up to the specified housing period. Haemophilus is a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." ;
rdfs:subClassOf obo:XCO_0000743 , obo:XCO_0000747 .
obo:XCO_0000037 a rdfs:Class ;
rdfs:label "housing with socially subordinate partner" ;
rdfs:subClassOf obo:XCO_0000035 , obo:XCO_0000490 .
obo:XCO_0000008 a rdfs:Class ;
rdfs:label "running" ;
rdfs:comment "This is any condition in which the main influencing factor is running, the action of rapid movement of feet that propels the organism forward or is done on an exercise machine so that the organism performs the activity in place." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0000692 a rdfs:Class ;
rdfs:label "carbachol" ;
rdfs:comment "An ammonium salt that has formula C6H15N2O2. It is a slowly hydrolyzed cholinergic agonist that acts at both muscarinic receptors and nicotinic receptors." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000693 .
obo:XCO_0000529 a rdfs:Class ;
rdfs:label "gene transfer using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is a gene transfer performed using an adenovirus as the carrier of the genetic material. An adenovirus is any of a group of medium-sized (90-100 nm) non-enveloped icosahedral viruses of the family Adenoviridae which are characterized by a nucleocapsid surrounding a double-stranded DNA genome. An adenovirus is a double-stranded DNA virus that can replicate independently." ;
rdfs:subClassOf obo:XCO_0000528 .
obo:XCO_0000088 a rdfs:Class ;
rdfs:label "chemical" ;
rdfs:comment "This is any condition in which the main influencing factor is a compound or substance that has been purified or prepared, especially artificially." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000331 a rdfs:Class ;
rdfs:label "RU28362" ;
rdfs:comment "Any condition in which the main influencing factor is RU28362, a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000468 a rdfs:Class ;
rdfs:label "vitamin A" ;
rdfs:comment "Condition in which the main influencing factor is vitamin A, a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids. Vitamin A is involved in immune function, vision, reproduction, and cellular communication." ;
rdfs:subClassOf obo:XCO_0000377 , obo:XCO_0000467 .
obo:XCO_0000978 a rdfs:Class ;
rdfs:label "acetyl-L-carnitine" ;
rdfs:comment "This is any condition in which the main influencing factor is an acetylated form of L-carnitine. It is naturally produced by the human body, and it is available as a dietary supplement. Acetyl-L-carnitine is broken down in the blood by plasma esterases to carnitine which is used by the body to transport fatty acids into the mitochondria for breakdown." ;
rdfs:subClassOf obo:XCO_0000561 .
obo:XCO_0001051 a rdfs:Class ;
rdfs:label "controlled soy protein isolate content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a solid diet in which the amount of soy protein isolate, usually containing 85%90% protein (dry basis), is maintained at a specified level. Soy protein isolates (SPI) are prepared by separating the fibers and insoluble carbohydrates from soy protein concentrate." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001415 a rdfs:Class ;
rdfs:label "double-distilled water" ;
rdfs:comment "This is any condition in which the main influencing factor is double distilled water, the secondary distillation of the water vapor of a prior distillation procedure. Double-distilled water (ddH2O) is traditionally considered the ‘most pure’ type of laboratory-grade water." ;
rdfs:subClassOf obo:XCO_0000917 .
obo:XCO_0000942 a rdfs:Class ;
rdfs:label "controlled saxagliptin content diet" ;
rdfs:comment "A solid diet in which the amount of saxagliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000632 .
obo:XCO_0001712 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to guanine deaminase MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to an autoantibody-generating level of guanine deaminase (GDA) multiple antigenic peptides (MAPs). This is a condition typically studied to determine the effect of maternal (F0) GDA exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001711 .
obo:XCO_0001363 a rdfs:Class ;
rdfs:label "CGS 21680-filled liposomes" ;
rdfs:comment "This is any condition in which the main influencing factor is CGS 21680-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing CGS 21680 hydrochloride. CGS 21680 is an adenosine A2a receptor (Adora2a) agonist." ;
rdfs:subClassOf obo:XCO_0000780 .
obo:XCO_0001856 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to unpredictable chronic mild stress" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to unpredictable chronic mild stress that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) unpredictable chronic mild stress exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001275 .
obo:XCO_0000645 a rdfs:Class ;
rdfs:label "propofol" ;
rdfs:comment "This is any condition in which the main influencing factor is propofol, an intravenous anesthetic agent which has a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. Propofol has also been used as an anticonvulsant and antiemetic." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000950 , obo:XCO_0001245 .
obo:XCO_0001475 a rdfs:Class ;
rdfs:label "Banxia Xiexin decoction" ;
rdfs:comment "This is any condition in which the main influencing factor is Banxia Xiexin decoction, an anti-inflammatory, anticancer, and antioxidative drug of traditional Chinese medicine (TCM). Banxia Xiexin decoction has been used to treat stress-induced gastric ulceration (SIGU) and many other gastrointestinal diseases. Banxia Xiexin decoction is a combination of seven different herbal medicines." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000435 , obo:XCO_0000505 .
obo:XCO_0001556 a rdfs:Class ;
rdfs:label "acadesine" ;
rdfs:comment "This is any condition in which the main influencing factor is acadesine, a purine nucleoside analogue and activator of AMP-activated protein kinase. Acadesine is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects." ;
rdfs:subClassOf obo:XCO_0000392 , obo:XCO_0000435 , obo:XCO_0000694 .
obo:XCO_0000243 a rdfs:Class ;
rdfs:label "partial pancreatectomy" ;
rdfs:comment "Surgical removal of a portion of the pancreas, resulting in reduction but not elimination of the physiological functions of the pancreas." ;
rdfs:subClassOf obo:XCO_0000105 .
obo:XCO_0001360 a rdfs:Class ;
rdfs:label "fecal transplantation from control donor" ;
rdfs:comment "This is any condition in which the main influencing factor is fecal transplantation from a control donor, an experimental procedure to collect feces from a control donor and introduce them into a recipient's gastrointestinal tract. This procedure is used to investigate gut dysbiosis in various conditions, including cancer and polycystic ovary syndrome." ;
rdfs:subClassOf obo:XCO_0001358 .
obo:XCO_0001531 a rdfs:Class ;
rdfs:label "gestational maternal exposure to hyperglycemia" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to hyperglycemia (blood glucose level > 180 mg/dl). This is a condition typically studied to determine the effect of maternal (F0) hyperglycemia exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001530 .
obo:XCO_0001356 a rdfs:Class ;
rdfs:label "ampicillin sodium" ;
rdfs:comment "This is any condition in which the main influencing factor is ampicillin sodium, the sodium salt form of ampicillin, a broad-spectrum semisynthetic derivative of aminopenicillin. Ampicillin sodium inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall." ;
rdfs:subClassOf obo:XCO_0001187 .
obo:XCO_0000869 a rdfs:Class ;
rdfs:label "incision repair with biosuture" ;
rdfs:comment "A process in which manual and instrumental techniques are used to close a wound or surgical incision with biosutures. Biosutures are surgical sutures upon which stem cells have been grown in vitro." ;
rdfs:subClassOf obo:XCO_0000867 .
obo:XCO_0001602 a rdfs:Class ;
rdfs:label "dehydration" ;
rdfs:comment "This is any condition in which the main influencing factor is dehydration, which occurs when a subject's body loses more fluids than it takes in, leading to a state where it doesn't have enough water and other fluids to function properly. In experimental animals dehydration may be used as a kidney stressor." ;
rdfs:subClassOf obo:XCO_0000021 .
obo:XCO_0000779 a rdfs:Class ;
rdfs:label "rat IgM immunocytoma cells" ;
rdfs:comment "A condition in which the main influencing factor is rat IgM-secreting immunocytoma cells. The transplantable tumor cells are used in various studies including antibody secretion studies and antitumoral drug studies." ;
rdfs:subClassOf obo:XCO_0000709 .
obo:XCO_0000189 a rdfs:Class ;
rdfs:label "physical restraint on immobilization board" ;
rdfs:comment "Immobilization of a subject on a frame or platform by securing all four limbs to it, e.g. by taping them to mounts attached to the frame, thereby eliminating the subject's ability to move at will." ;
rdfs:subClassOf obo:XCO_0000158 .
obo:XCO_0001728 a rdfs:Class ;
rdfs:label "gene transfer of the human CYP11A1 gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the transfer (transiently or stably) of the human CYP11A1 (cytochrome P450 family 11 subfamily A member 1) gene into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000432 a rdfs:Class ;
rdfs:label "sucrose" ;
rdfs:comment "Any condition in which the main influencing factor is sucrose, a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid." ;
rdfs:subClassOf obo:XCO_0000431 .
obo:XCO_0001203 a rdfs:Class ;
rdfs:label "phenobarbital" ;
rdfs:comment "This is any condition in which the main influencing factor is phenobarbital, a barbiturate that acts as a nonselective central nervous system depressant. Phenobarbital potentiates GABA action on GABA-A receptors, modulates chloride currents through receptor channels, and inhibits glutamate induced depolarizations." ;
rdfs:subClassOf obo:XCO_0000950 , obo:XCO_0001122 .
obo:XCO_0001136 a rdfs:Class ;
rdfs:label "propylene glycol" ;
rdfs:comment "This is any condition in which the main influencing factor is propylene glycol, a synthetic small organic alcohol that is hydrophylic. Propylene glycol has various laboratory, pharmaceutical, and industrial uses." ;
rdfs:subClassOf obo:XCO_0000323 .
obo:XCO_0000833 a rdfs:Class ;
rdfs:label "lacidipine" ;
rdfs:comment "Any condition in which the main influencing factor is lacidipine, a lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000269 , obo:XCO_0000511 .
obo:XCO_0000149 a rdfs:Class ;
rdfs:label "ion/salt" ;
rdfs:comment "Any condition in which the main influencing factor is an atom or molecule that has gained or lost one or more electrons and thereby acquired a charge, or is any of a large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion)." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001262 a rdfs:Class ;
rdfs:label "ximelagatran" ;
rdfs:comment "This is any condition in which the main influencing factor is ximelagatran, which is an anticoagulant, a serine protease inhibitor and a prodrug for melagatran." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0001090 .
obo:XCO_0000527 a rdfs:Class ;
rdfs:label "genetic manipulation" ;
rdfs:comment "A condition in which the genotype or the gene expression of an organism or a cell has been modified." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000109 a rdfs:Class ;
rdfs:label "isoflurane" ;
rdfs:comment "Potent inhalational anesthetic." ;
rdfs:subClassOf obo:XCO_0000106 .
obo:XCO_0001472 a rdfs:Class ;
rdfs:label "alectinib" ;
rdfs:comment "This is any condition in which the main influencing factor is alectinib, an organic heterotetracyclic compound, a member of morpholines, a member of piperidines, a nitrile and an aromatic ketone. Alectinib is an antineoplastic inhibitor of the receptor tyrosine kinase ALK (anaplastic lymphoma kinase). It is used to treat ALK-positive NSCLC (non-small cell lung cancer)." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000970 .
obo:XCO_0001143 a rdfs:Class ;
rdfs:label "Limosilactobacillus reuteri" ;
rdfs:comment "This is any condition in which the main influencing factor is Limosilactobacillus reuteri (a lactic acid bacterium). L. reuteri is a probiotic bacterium found in a variety of natural environments, including the gastrointestinal tract of humans and other animals." ;
rdfs:subClassOf obo:XCO_0001212 .
obo:XCO_0000945 a rdfs:Class ;
rdfs:label "controlled taxifolin content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of taxifolin in which the amount of taxifolin consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001613 a rdfs:Class ;
rdfs:label "recombinant alteplase" ;
rdfs:comment "This is any condition in which the main influencing factor is recombinant alteplase, a biosynthetic form of human tissue-type plasminogen activator (t-PA). Alteplase is an anticoagulant which converts plasminogen to plasmin (fibrinolysin)." ;
rdfs:subClassOf obo:XCO_0000176 , obo:XCO_0000694 , obo:XCO_0001090 .
obo:XCO_0001520 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to controlled air oxygen content" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to controlled air oxygen content that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) controlled air oxygen content exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001525 .
obo:XCO_0001138 a rdfs:Class ;
rdfs:label "cefprozil" ;
rdfs:comment "This is any condition in which the main influencing factor is cefprozil, a semisynthetic, second-generation cephalosporin. Cefprozil is used to treat bronchitis as well as ear, skin and other bacterial infections." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0001020 a rdfs:Class ;
rdfs:label "docosahexaenoic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds." ;
rdfs:subClassOf obo:XCO_0000776 .
obo:XCO_0000186 a rdfs:Class ;
rdfs:label "cytisine" ;
rdfs:comment "A toxic selective nicotinic cholinergic alkaloid from the seed of Laburnum anagyroides and other Leguminosae. Used in pharmacological studies of nicotinic cholinergic receptors in the brain." ;
rdfs:subClassOf obo:XCO_0000693 .
obo:XCO_0001422 a rdfs:Class ;
rdfs:label "allogeneic liver transplant" ;
rdfs:comment "This is any condition in which the main influencing factor is an allogeneic liver transplant, a surgical procedure in which a whole or partial liver from a donor organism is implanted into a genetically non-identical recipient organism of the same species for the clinical purpose of replacing a diseased liver or for the experimental purpose of studying organ transplantation." ;
rdfs:subClassOf obo:XCO_0001421 .
obo:XCO_0001780 a rdfs:Class ;
rdfs:label "moderate ambient light exposure" ;
rdfs:comment "This is any condition in which the main influencing factor is exposure to controlled moderate ambient light at an intensity of about 1,000 to 15,000 lux, which is somewhere between normal home lighting (50-150 lux) and direct sunlight (100,000 lux). 1,000 lux means that 1000 lumens (a measure of total light output) are distributed over an area of 1 square meter (1000 lm/m²)." ;
rdfs:subClassOf obo:XCO_0000182 .
obo:XCO_0001565 a rdfs:Class ;
rdfs:label "gestational maternal exposure to perfluorohexane sulfonate" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to perfluorohexane sulfonate. This is a condition typically studied to determine the effect of maternal (F0) perfluorohexane sulfonate use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001564 .
obo:XCO_0000345 a rdfs:Class ;
rdfs:label "N-ethyl-N-nitrosourea" ;
rdfs:comment "Any condition in which the main influencing factor is a chemical with three major moieties, an ethyl group (a two-carbon alkyl substituent with chemical formula -C2H5), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." ;
rdfs:subClassOf obo:XCO_0000205 , obo:XCO_0000343 .
obo:XCO_0000876 a rdfs:Class ;
rdfs:label "floxuridine" ;
rdfs:comment "This is an antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." ;
rdfs:subClassOf obo:XCO_0000390 , obo:XCO_0000435 , obo:XCO_0000657 .
obo:XCO_0001200 a rdfs:Class ;
rdfs:label "panadiplon" ;
rdfs:comment "This is any condition in which the main influencing factor is panadiplon (U-78875), an anxiolytic drug with a novel chemical structure. Panadiplon has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and relatively little sedative or amnestic effect, and so is classified as a nonbenzodiazepine anxiolytic." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0001122 .
obo:XCO_0000387 a rdfs:Class ;
rdfs:label "collagenase-solubilized rat glomerular basement membrane" ;
rdfs:comment "A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli from rats (i.e., members of the species Rattus norvegicus) via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells." ;
rdfs:subClassOf obo:XCO_0000386 .
obo:XCO_0000967 a rdfs:Class ;
rdfs:label "gastric bypass" ;
rdfs:comment "This is any condition in which the main influencing factor is a gastric bypass, a type of weight-loss surgery that involves creating a small pouch from the stomach and connecting the newly created pouch directly to the small intestine. After gastric bypass, swallowed food will go into this small pouch of stomach and then directly into the small intestine, thereby bypassing most of the stomach and the first section of the small intestine." ;
rdfs:subClassOf obo:XCO_0001436 .
obo:XCO_0001154 a rdfs:Class ;
rdfs:label "dipyridamole" ;
rdfs:comment "This is any condition whose main influencing factor is dipyridamole, a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole is an inhibitor of platelet aggregation and a vasodilator agent." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000523 .
obo:XCO_0000270 a rdfs:Class ;
rdfs:label "captopril" ;
rdfs:comment "A sulfur-containing carboxylic acid with a pyrrolidine substituent at C-1, which decreases or interferes with the activity of angiotensin converting enzyme (ACE) inhibitor, used as an anti-hypertensive drug." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000524 .
obo:XCO_0001464 a rdfs:Class ;
rdfs:label "citrate buffer" ;
rdfs:comment "This is any condition in which the main influencing factor is citrate buffer, a combination of sodium citrate dihydrate and citric acid in water to form a solution with a pH range of 3.0 to 6.2." ;
rdfs:subClassOf obo:XCO_0000315 .
obo:XCO_0001229 a rdfs:Class ;
rdfs:label "Baihu-Guizhi decoction" ;
rdfs:comment "This is any condition in which the main influencing factor is Baihu-Guizhi decoction, an anti-arthritic drug of traditional Chinese medicine (TCM). Baihu-Guizhi decoction (BHGZD) is extensively used for the treatment of rheumatoid arthritis (RA)." ;
rdfs:subClassOf obo:XCO_0000505 , obo:XCO_0001623 .
obo:XCO_0000500 a rdfs:Class ;
rdfs:label "paraquat" ;
rdfs:comment "A condition in which the main influencing factor is paraquat, a herbicidal organic cation used to model Parkinson's disease in mice." ;
rdfs:subClassOf obo:XCO_0000495 , obo:XCO_0000497 .
obo:XCO_0001359 a rdfs:Class ;
rdfs:label "fecal transplantation from DHEA-treated donor" ;
rdfs:comment "This is any condition in which the main influencing factor is fecal transplantation from a DHEA (dehydroepiandrosterone)-treated donor, an experimental procedure to collect feces from a DHEA-treated donor and introduce them into a recipient's gastrointestinal tract. This procedure is used to investigate gut dysbiosis in various conditions, including cancer and polycystic ovary syndrome." ;
rdfs:subClassOf obo:XCO_0001358 .
obo:XCO_0000667 a rdfs:Class ;
rdfs:label "clenbuterol" ;
rdfs:comment "A beta-adrenergic receptor agonist that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group." ;
rdfs:subClassOf obo:XCO_0000665 , obo:XCO_0000666 .
obo:XCO_0001829 a rdfs:Class ;
rdfs:label "human umbilical cord-derived mesenchymal stem cells" ;
rdfs:comment "This is any condition in which the main influencing factor is human, umbilical cord-derived mesenchymal stem cells. These cells are obtained from human umbilical cord blood and are multipotent cells capable of differentiating into various cell types, such as adipocytes, chondrocytes, myocytes, and osteoblasts." ;
rdfs:subClassOf obo:XCO_0001393 .
obo:XCO_0001740 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to dicyclohexyl phthalate" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to dicyclohexyl phthalate that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) dicyclohexyl phthalate exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001739 .
obo:XCO_0001040 a rdfs:Class ;
rdfs:label "(R)-lipoic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is (R)-lipoic acid, the (R)-enantiomer of lipoic acid. Lipoic acid is a vitamin-like, C8 thia fatty acid with anti-oxidant properties." ;
rdfs:subClassOf obo:XCO_0000777 .
obo:XCO_0000457 a rdfs:Class ;
rdfs:label "controlled retinoid content diet" ;
rdfs:comment "A solid diet in which the amount of any retinoid is maintained at a specified level. Retinoids comprise retinal, retinol and any structurally similar natural derivative or synthetic compound, with or without vitamin A activity." ;
rdfs:subClassOf obo:XCO_0000690 .
obo:XCO_0001374 a rdfs:Class ;
rdfs:label "spared nerve injury" ;
rdfs:comment "This is any condition in which the main influencing factor is spared nerve injury, a model of neuropathic pain in rodents. The model consists of ligation/transection of the common peroneal and tibial nerves (two of the three branches of the sciatic nerve), while the sural nerve (third branch of the sciatic nerve) is left intact. This allows mechanical allodynia to be measured on the surface of the ipsilateral paw." ;
rdfs:subClassOf obo:XCO_0001373 .
obo:XCO_0001844 a rdfs:Class ;
rdfs:label "climbing" ;
rdfs:comment "This is any condition in which the main influencing factor is climbing, the act of ascending or descending a steep object." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0000275 a rdfs:Class ;
rdfs:label "glucose" ;
rdfs:comment "A monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues. It is one of the three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms." ;
rdfs:subClassOf obo:XCO_0000274 .
obo:XCO_0001553 a rdfs:Class ;
rdfs:label "Lieber-DeCarli control liquid diet" ;
rdfs:comment "This is any condition in which the main influencing factor is Lieber-DeCarli control liquid diet, a liquid diet whose calories are 50% carbohydrate, 35% fat, and 15% protein." ;
rdfs:subClassOf obo:XCO_0001552 .
obo:XCO_0000505 a rdfs:Class ;
rdfs:label "anti-inflammatory agent" ;
rdfs:comment "A condition in which the main influencing factor is a chemical which counteracts or suppresses inflammation." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0001491 a rdfs:Class ;
rdfs:label "calycosin" ;
rdfs:comment "This is any condition in which the main influencing factor is calycosin, a 7-hydroxyisoflavone that functions as an antioxidant." ;
rdfs:subClassOf obo:XCO_0000271 .
obo:XCO_0000891 a rdfs:Class ;
rdfs:label "phorbol 13-acetate 12-myristate" ;
rdfs:comment "Phorbol 13-acetate 12-myristate is a phorbol ester found in croton oil with very effective tumor promoting activity. It is a protein kinase C agonist and stimulates the synthesis of both DNA and RNA." ;
rdfs:subClassOf obo:XCO_0000694 , obo:XCO_0000892 .
obo:XCO_0000764 a rdfs:Class ;
rdfs:label "rat anti-Ab2 T cell line" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies." ;
rdfs:subClassOf obo:XCO_0000762 .
obo:XCO_0000001 a rdfs:Class ;
rdfs:label "activity" ;
rdfs:comment "The state of being involved in some action, either physical or mental." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000887 a rdfs:Class ;
rdfs:label "pentetrazol" ;
rdfs:comment "This a pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive gamma-aminobutyric acid antagonist. Pentetrazol has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility." ;
rdfs:subClassOf obo:XCO_0000886 .
obo:XCO_0000083 a rdfs:Class ;
rdfs:label "standing position" ;
rdfs:comment "A position in which an organism is upright balanced on two legs for bipedal organisms or four legs for quadrapedal organisms." ;
rdfs:subClassOf obo:XCO_0000081 .
obo:XCO_0000418 a rdfs:Class ;
rdfs:label "phytoestrogen-free diet" ;
rdfs:comment "A solid diet which specifically contains no phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants." ;
rdfs:subClassOf obo:XCO_0000419 .
obo:XCO_0001273 a rdfs:Class ;
rdfs:label "high-protein/ammoniagenic diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a high-protein/ammoniagenic diet, which is a standard diet supplemented with additional amino acids including leucine (~13% of amino acids), valine (~11% of amino acids), and the absence of isoleucine." ;
rdfs:subClassOf obo:XCO_0000030 .
obo:XCO_0001483 a rdfs:Class ;
rdfs:label "controlled in situ liver condition" ;
rdfs:comment "This is any condition in which the main influencing factor is the experimental manipulation of the internal or external environment of the liver, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." ;
rdfs:subClassOf obo:XCO_0000166 .
obo:XCO_0001764 a rdfs:Class ;
rdfs:label "adrenaline" ;
rdfs:comment "This is any condition in which the main influencing factor is adrenaline, a neurotransmitter and sympathomimetic hormone from the adrenal medulla. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. As a medication adrenaline is used in asthma and cardiac failure and to delay absorption of local anesthetics." ;
rdfs:subClassOf obo:XCO_0000125 , obo:XCO_0000141 , obo:XCO_0000144 , obo:XCO_0000664 , obo:XCO_0000666 .
obo:XCO_0000656 a rdfs:Class ;
rdfs:label "ganciclovir" ;
rdfs:comment "An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections" ;
rdfs:subClassOf obo:XCO_0000657 .
obo:XCO_0001624 a rdfs:Class ;
rdfs:label "RG2833" ;
rdfs:comment "This is any condition in which the main influencing factor is RG2833, a brain-penetrant histone deacetylase 1/3 (HDAC1/3) inhibitor. It is being investigated as a potential therapeutic agent for cancer, neurological disorders, and other conditions." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001489 a rdfs:Class ;
rdfs:label "antifungal agent" ;
rdfs:comment "This is any condition in which the main influencing factor is an antifungal agent, a substance or other entity that kills or slows the growth of fungi." ;
rdfs:subClassOf obo:XCO_0000482 .
obo:XCO_0000746 a rdfs:Class ;
rdfs:label "housing with Pasteurella pneumotropica-infected subject" ;
rdfs:comment "A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurella pneumotropica infection during the time period leading up to the specified housing period. Pasteurella pneumotropica is a strain of Pasteurella, a genus Gram-negative, coccobacilli bacteria, some of which are pathogenic." ;
rdfs:subClassOf obo:XCO_0000747 .
obo:XCO_0000670 a rdfs:Class ;
rdfs:label "Pair-fed diet" ;
rdfs:comment "A technique in which the amount of food provided to a control group of animals is matched to that consumed by the experimental group, so as to determine the extent to which the effect of a treatment on body weight or body composition occurred independently of changes of energy intake." ;
rdfs:subClassOf obo:XCO_0000461 .
obo:XCO_0001566 a rdfs:Class ;
rdfs:label "maternal exposure to perfluorohexane sulfonate during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to perfluorohexane sulfonate during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) perfluorohexane sulfonate use/exposure during the postnatal, preweaning period on the F1 offspring." .
obo:XCO_0001271 a rdfs:Class ;
rdfs:label "zimelidine" ;
rdfs:comment "This is any condition in which the main influencing factor is zimelidine, an SRI (serotonin uptake inhibitor) antidepressant whose use was discontinued because of the risk of Guillain-Barre syndrome as a side effect." ;
rdfs:subClassOf obo:XCO_0000561 .
obo:XCO_0000797 a rdfs:Class ;
rdfs:label "Y-27632" ;
rdfs:comment "A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It is a cell-permeable, reversible inhibitor of Rho-associated protein kinase (ROCK) enzyme." ;
rdfs:subClassOf obo:XCO_0000970 .
obo:XCO_0000232 a rdfs:Class ;
rdfs:label "nucleic acid" ;
rdfs:comment "A high-molecular-weight polymeric compound composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose or deoxyribose sugar, and a phosphate group." ;
rdfs:subClassOf obo:XCO_0001107 .
obo:XCO_0001545 a rdfs:Class ;
rdfs:label "gestational maternal exposure to oxytocin" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to oxytocin. This is a condition typically studied to determine the effect of maternal (F0) oxytocin use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001543 , obo:XCO_0001544 .
obo:XCO_0000507 a rdfs:Class ;
rdfs:label "carprofen" ;
rdfs:comment "Condition in which the main influencing factor is a non-steroidal anti-inflammatory drug with chemical formula C15H12ClNO2, used as a veterinary analgesic." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000506 .
obo:XCO_0000066 a rdfs:Class ;
rdfs:label "body position change" ;
rdfs:comment "Change in position or attitude of body as part of the experiment in which measurements are taken before, during and/or after the change." ;
rdfs:subClassOf obo:XCO_0000081 .
obo:XCO_0000099 a rdfs:Class ;
rdfs:label "control condition" ;
rdfs:comment "This is any condition in which the major influencing factor is a uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison. It is a baseline condition in which none of the experimental manipulations are performed." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000429 a rdfs:Class ;
rdfs:label "controlled fructose content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of fructose consumed by a subject. Fructose is one of three dietary monosaccharides that are absorbed directly into the bloodstream during digestion." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000026 a rdfs:Class ;
rdfs:label "surgical removal" ;
rdfs:comment "The process of ablating or extracting all or part of an organ, gland or other body part from an organism as a medical or experimental procedure." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001345 a rdfs:Class ;
rdfs:label "splenic ultrasound neuromodulation" ;
rdfs:comment "This is any condition in which the main influencing factor is splenic stimulation via ultrasound, a method to noninvasively modulate neural signaling in the spleen." ;
rdfs:subClassOf obo:XCO_0000520 .
obo:XCO_0000019 a rdfs:Class ;
rdfs:label "solid diet" ;
rdfs:comment "The solid food that is consumed by an organism." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0000946 a rdfs:Class ;
rdfs:label "midafotel" ;
rdfs:comment "This is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and originally designed as a potential therapy for excitotoxicity, epilepsy or neuropathic pain." ;
rdfs:subClassOf obo:XCO_0000947 .
obo:XCO_0001478 a rdfs:Class ;
rdfs:label "controlled ex vivo liver condition" ;
rdfs:comment "This is an experimental condition in which the internal or external environment of a liver is manipulated or regulated, for example through perfusion, increased or decreased blood flow, temperature, etc. after removal from the body." ;
rdfs:subClassOf obo:XCO_0000464 .
obo:XCO_0000310 a rdfs:Class ;
rdfs:label "guanethidine" ;
rdfs:comment "An antihypertensive agent that acts by selectively inhibiting transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. It does not appear to act at the level of the adrenergic receptors." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0000023 a rdfs:Class ;
rdfs:label "controlled ethanol content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, for consumption by an organism in an experiment." ;
rdfs:subClassOf obo:XCO_0000070 , obo:XCO_0000163 .
obo:XCO_0000607 a rdfs:Class ;
rdfs:label "acetic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is acetic acid, the product of the oxidation of ethanol and of the destructive distillation of wood. Acetic acid is used locally, occasionally internally, as a counterirritant and also as a reagent." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001117 a rdfs:Class ;
rdfs:label "pefloxacin" ;
rdfs:comment "This is any condition in which the main influencing factor is pefloxacin, a substituted quinolone that is an antibacterial agent and inhibitor of DNA biosynthesis." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000523 .
obo:XCO_0000260 a rdfs:Class ;
rdfs:label "peptide/protein antigen" ;
rdfs:comment "A condition in which the major influencing factor is a peptide or protein, that is, any of a group of complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, capable of inducing a specific localized and/or systemic immune response." ;
rdfs:subClassOf obo:XCO_0000133 , obo:XCO_0000193 .
obo:XCO_0001694 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to housing with intruder-resident paradigm" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to housing with intruder-resident paradigm that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) housing with intruder-resident paradigm exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001693 .
obo:XCO_0000333 a rdfs:Class ;
rdfs:label "controlled RU28362 content saline drink" ;
rdfs:comment "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of RU28362, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor." ;
rdfs:subClassOf obo:XCO_0000164 , obo:XCO_0000332 .
obo:XCO_0001080 a rdfs:Class ;
rdfs:label "monoiodoacetate" ;
rdfs:comment "This is any condition in which the main influencing factor is monoiodoacetate, a haloacetate(1-) resulting from the deprotonation of the carboxy group of iadoacetic acid." ;
rdfs:subClassOf obo:XCO_0000149 , obo:XCO_0000261 .
obo:XCO_0001103 a rdfs:Class ;
rdfs:label "17beta-estradiol 3-benzoate" ;
rdfs:comment "This is any condition in which the main influencing factor is 17beta-estradiol 3-benzoate, the C17β benzoate ester of estradiol." ;
rdfs:subClassOf obo:XCO_0000092 .
obo:XCO_0000480 a rdfs:Class ;
rdfs:label "nontypeable Haemophilus influenzae" ;
rdfs:comment "A condition in which the primary influencing factor is one or more nontypeable strain(s) of Haemophilus influenzae (NTHi). NTHi refers to any unencapsulated strain of the Gram-negative, coccobacillary, facultatively anaerobic bacterium species Haemophilus influenza. Such bacteria lack the capsular antigens used to serotype strains and therefore cannot be classified by serology. NTHi strains are the important pathogens in chronic and recurrent otitis media in children." ;
rdfs:subClassOf obo:XCO_0000479 .
obo:XCO_0000302 a rdfs:Class ;
rdfs:label "lithium chloride solution" ;
rdfs:comment "A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000301 .
obo:XCO_0000365 a rdfs:Class ;
rdfs:label "Toxoplasma gondii cysts" ;
rdfs:comment "A condition in which the main influencing factor is Toxoplasma gondii cysts. Toxoplasma gondii is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis. Cyst refers to the larval stage in the life cycle during which individual organisms are enveloped in a protective wall." ;
rdfs:subClassOf obo:XCO_0000364 .
obo:XCO_0001389 a rdfs:Class ;
rdfs:label "methylcellulose 400" ;
rdfs:comment "This is any condition in which the main influencing factor is methylcellulose 400, an aqueous solution of methylcellulose with a dynamic viscosity of 400 centipoise (cP). Methylcellulose is a methylester of cellulose used as an emulsifying and suspending agent in cosmetics, pharmaceuticals and the chemical industry. It is used therapeutically as a bulk laxative." ;
rdfs:subClassOf obo:XCO_0000789 .
obo:XCO_0000554 a rdfs:Class ;
rdfs:label "controlled phosphorus content diet" ;
rdfs:comment "A regimen of solid food in which the amount of phosphorus consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001859 a rdfs:Class ;
rdfs:label "muscle graft" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a muscle graft. This is a surgical procedure intended to restore lost or impaired muscle function." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0001303 a rdfs:Class ;
rdfs:label "sinomenine" ;
rdfs:comment "This is any condition in which the main influencing factor is sinomenine, a unique plant alkaloid that releases histamine in association with degranulation of tissue mast cells in mammalian tissues. Sinomenine has been used in herbal medicine for the treatment of rheumatism and arthritis. Sinomenine also has anti-angiogenic, anti-inflammatory, and anti-apoptotic effects." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000505 .
obo:XCO_0000538 a rdfs:Class ;
rdfs:label "temocapril" ;
rdfs:comment "An experimental condition in which the main influencing factor is temocapril, an angiotensin-I converting enzyme (ACE) inhibitor consisting of a dipeptide prodrug with a thiazepine ring." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0000786 a rdfs:Class ;
rdfs:label "PRObR1 cells" ;
rdfs:comment "A rat cell line (PROb 5-FU-resistant subline) derived from colonic adenocarcinoma PROb cells. The R1 cell line was established from PROb cells by in vivo and in vitro adaptation to 5-fluorouracil (5-FU), an anticancer drug." ;
rdfs:subClassOf obo:XCO_0000785 .
obo:XCO_0001480 a rdfs:Class ;
rdfs:label "histidine-tryptophan-ketoglutarate solution" ;
rdfs:comment "This is any condition in which the main influencing factor is histidine-tryptophan-ketoglutarate (HTK) solution, a cardioplegic solution used in open heart surgery that is increasingly being used as a preservation solution for kidneys. in HTK tryptophan serves as a membrane stabilizer and antioxidant, ketoglutarate acts as a substrate for anaerobic metabolism during preservation and histidine serves as a pH-buffering component." ;
rdfs:subClassOf obo:XCO_0000315 .
obo:XCO_0001277 a rdfs:Class ;
rdfs:label "nicotinamide" ;
rdfs:comment "This is any condition in which the main influencing factor is nicotinamide, a pyridine derivative that is a component of the coenzyme NAD, a form of vitamin B3, an antioxidant, a histone deacetylase inhibitor, and an anti-inflammatory agent." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000505 , obo:XCO_0000523 .
obo:XCO_0000196 a rdfs:Class ;
rdfs:label "glybenclamide" ;
rdfs:comment "ATP-sensitive potassium channel inhibitor used as an anti-arrhythmia drug and a hypoglycemic/anti-diabetes drug. In the latter case, the drug causes beta cell membrane depolarization, which in turn results in opening of voltage-dependent calcium channels and subsequent insulin release." ;
rdfs:subClassOf obo:XCO_0000225 .
obo:XCO_0000479 a rdfs:Class ;
rdfs:label "Haemophilus influenzae" ;
rdfs:comment "A condition in which the primary influencing factor is Haemophilus influenzae, a Gram-negative, coccobacillary, facultatively anaerobic bacterium which is considered an opportunistic pathogen, i.e. one that can colonize a host without causing disease unless there are extenuating circumstances which result in susceptibility on the part of the host." ;
rdfs:subClassOf obo:XCO_0000743 .
obo:XCO_0001223 a rdfs:Class ;
rdfs:label "sitaxentan" ;
rdfs:comment "This is any condition in which the main influencing factor is sitaxentan, a drug designed for the treatment of pulmonary arterial hypertension (PAH). The use of sitaxentan was discontinued because of the side effect of hepatotoxicity." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001197 a rdfs:Class ;
rdfs:label "nevirapine" ;
rdfs:comment "This is any condition in which the main influencing factor is nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infections and acquired immunodeficiency syndrome (AIDS)." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0000657 .
obo:XCO_0001646 a rdfs:Class ;
rdfs:label "gene transfer of the rat Ctnnd2 gene using an adeno-associated virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of the rat Ctnnd2 (catenin delta 2) gene using an adeno-associated virus vector. Gene transfer into a cell or organism using an adeno-associated virus vector is performed to induce synthesis of the carried gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0001575 .
obo:XCO_0001106 a rdfs:Class ;
rdfs:label "retinal reperfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is retinal reperfusion, the flow of blood to the retina being restored after a period of blood vessel occlusion occurring experimentally." ;
rdfs:subClassOf obo:XCO_0001105 .
obo:XCO_0001135 a rdfs:Class ;
rdfs:label "carbamazepine" ;
rdfs:comment "This is any condition in which the main influencing factor is carbamazepine, a dibenzazepine that acts as a sodium channel blocker. Carbamazepine is used as an anticonvulsant and it may also be used in the management of bipolar disorder and neuropathic pain." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000618 , obo:XCO_0000950 .
obo:XCO_0001486 a rdfs:Class ;
rdfs:label "L4/L5 spinous process resection sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is L4/L5 spinous process sham resection, which follows the same surgical process through the posterior paravertebral muscle and other soft tissue detachment from the L4-L5 vertebrae, but no spinous process resection occurs." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000004 a rdfs:Class ;
rdfs:label "walking on treadmill" ;
rdfs:comment "The action of ambulation on an exercise apparatus with an endless moving belt on which the organism can walk in place." ;
rdfs:subClassOf obo:XCO_0000007 .
obo:XCO_0001367 a rdfs:Class ;
rdfs:label "medial meniscus transection" ;
rdfs:comment "This is any condition in which the main influencing factor is medial meniscus transection, a model of osteoarthritis (OA) in the laboratory rat. The procedure involves transection of the medial collateral ligament, incision of the synovial membrane, and full transsection of the medial meniscus so as to form anterior and posterior halves of the meniscus." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001186 a rdfs:Class ;
rdfs:label "MK-3207" ;
rdfs:comment "This is any condition in which the main influencing factor is MK-03207, a highly potent calcitonin gene-related peptide (CGRP) receptor antagonist designed to be an antimigraine therapeutic." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000719 a rdfs:Class ;
rdfs:label "gadopentetate dimeglumine" ;
rdfs:comment "A gadolinium coordination entity that has formula C28H54GdN5O20." ;
rdfs:subClassOf obo:XCO_0000718 .
obo:XCO_0001419 a rdfs:Class ;
rdfs:label "transgenerational maternal exposure to distilled deionized water" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to distilled, deionized water used as a vehicle control for transgenerational effects of some chemical. This is a condition typically studied to control for the effect of maternal (F0) chemical use/exposure on the F2/F3 offspring by direct effects on the F1/F2 generations in utero or during nursing, or by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of F1 offspring to affect the F2 generation. The maternal exposure may be any time after gestational development of germline cells in the F1 generation up to the time of weaning of F1 offspring to affect the F3 generation." ;
rdfs:subClassOf obo:XCO_0000101 , obo:XCO_0001416 .
obo:XCO_0001352 a rdfs:Class ;
rdfs:label "controlled neomycin sulfate content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of neomycin sulfate, the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin is a protein synthesis inhibitor and bacteriacidal agent." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0001188 .
obo:XCO_0001063 a rdfs:Class ;
rdfs:label "pinealectomy" ;
rdfs:comment "This is any condition in which the main influencing factor is the surgical excision of the pineal body, a midline, cone-like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000440 a rdfs:Class ;
rdfs:label "controlled 3-methyl-4'-dimethylaminoazobenzene content diet" ;
rdfs:comment "A solid diet in which the amount of 3'-methyl-4-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000574 a rdfs:Class ;
rdfs:label "controlled vancomycin content drinking water" ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0000572 .
obo:XCO_0000827 a rdfs:Class ;
rdfs:label "rat anti-Hu-S102-129 T cell line" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with synthetic human myelin basic protein peptide 102-129." ;
rdfs:subClassOf obo:XCO_0000763 .
obo:XCO_0000708 a rdfs:Class ;
rdfs:label "controlled carvedilol content diet" ;
rdfs:comment "A regimen of solid food in which the amount of carvedilol consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000707 .
obo:XCO_0001408 a rdfs:Class ;
rdfs:label "controlled dextran sulfate sodium content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of dextran sulfate sodium, a synthetic, sulfated polysaccharide with anticoagulant activity used in immunological research to induce colitis." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001830 a rdfs:Class ;
rdfs:label "irinotecan" ;
rdfs:comment "This is any condition in which the main influencing factor is irinotecan, a topoisomerase inhibitor used to treat colorectal and pancreatic cancer." ;
rdfs:subClassOf obo:XCO_0000323 , obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0001085 a rdfs:Class ;
rdfs:label "experimental epidural spinal cord compression" ;
rdfs:comment "This is a condition induced by an experimental surgical procedure involving disruption of CSF circulation in the spinal cord. This artificial compression is intended to mimic the human disease canalicular syringomyelia." ;
rdfs:subClassOf obo:XCO_0001091 .
obo:XCO_0000725 a rdfs:Class ;
rdfs:label "cyclodextrin (CD)-clathrated hesperetin" ;
rdfs:comment "Hesperetin is the aglycone of hesperidin - clathration by CD enhances hesperetin solubility." ;
rdfs:subClassOf obo:XCO_0000603 .
obo:XCO_0001247 a rdfs:Class ;
rdfs:label "sterile water" ;
rdfs:comment "This is any condition in which the main influencing factor is sterile water, which is high quality water used for medical irrigation, injection, or inhalation and has been prepared to eliminate microbial contamination. Sterile water may be used as a pharmaceutical solvent." ;
rdfs:subClassOf obo:XCO_0000021 .
obo:XCO_0000105 a rdfs:Class ;
rdfs:label "pancreatectomy" ;
rdfs:comment "Surgical removal of part or all of the pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0001423 a rdfs:Class ;
rdfs:label "syngeneic liver transplant" ;
rdfs:comment "This is any condition in which the main influencing factor is a syngeneic liver transplant, a surgical procedure in which a whole or partial liver from a donor organism is implanted into a genetically identical/nearly identical recipient organism of the same species for the clinical purpose of replacing a diseased liver or for the experimental purpose of studying organ transplantation." ;
rdfs:subClassOf obo:XCO_0001421 .
obo:XCO_0000901 a rdfs:Class ;
rdfs:label "controlled delapril content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of delapril in which the amount of delapril consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000710 a rdfs:Class ;
rdfs:label "DHD/K12/TRb cells" ;
rdfs:comment "A condition in which the main influencing factor is a rat colonic carcinoma cell line used to study biochemical correlates of metastasis." ;
rdfs:subClassOf obo:XCO_0000709 .
obo:XCO_0001497 a rdfs:Class ;
rdfs:label "gestational maternal exposure to bisphenol A" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to bisphenol A. This is a condition typically studied to determine the effect of maternal (F0) bisphenol A use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001494 .
obo:XCO_0001870 a rdfs:Class ;
rdfs:label "simplified galactic cosmic radiation" ;
rdfs:comment "This is any condition in which the main influencing factor is simplified galactic cosmic radiation, a type of ionizing radiation consisting of a five-ion group of high energy-charged particle beams intended to simulate the composition of galactic cosmic radiation behind spacecraft shielding." ;
rdfs:subClassOf obo:XCO_0001869 .
obo:XCO_0001817 a rdfs:Class ;
rdfs:label "4% O2, 20% CO2, 76%N2" ;
rdfs:comment "This is any condition in which the main influencing factor is the level of carbon dioxide (20%), oxygen (4%), and nitrogen (76%) in the air surrounding the organism or breathed by the organism as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000010 .
obo:XCO_0001091 a rdfs:Class ;
rdfs:label "experimental spinal cord injury" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental spinal cord injury, a penetrating or non-penetrating injury to the spinal cord resulting from experimentally controlled trauma." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001266 a rdfs:Class ;
rdfs:label "cage tilt" ;
rdfs:comment "This is any condition in which the main influencing factor is cage tilt, a procedure designed to cause mild stress in laboratory animals. Typically, the cage is tilted at 30 - 45 degrees for a few hours at a time to overnight." .
obo:XCO_0000344 a rdfs:Class ;
rdfs:label "N-propyl-N-nitrosourea" ;
rdfs:comment "Any condition in which the main influencing factor is a chemical with three major moieties, a propyl group (a linear three-carbon alkyl substituent with chemical formula -C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000205 , obo:XCO_0000343 .
obo:XCO_0001632 a rdfs:Class ;
rdfs:label "SCH 23390" ;
rdfs:comment "This is any condition in which the main influencing factor is SCH 23390, a selective dopamine receptor D1 (DRD1) antagonist." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000034 a rdfs:Class ;
rdfs:label "individual housing" ;
rdfs:subClassOf obo:XCO_0000033 .
obo:XCO_0000084 a rdfs:Class ;
rdfs:label "supine position" ;
rdfs:comment "A position in which the organism is lying face up." ;
rdfs:subClassOf obo:XCO_0000081 .
obo:XCO_0001490 a rdfs:Class ;
rdfs:label "lysergic acid diethylamide" ;
rdfs:comment "This is any condition in which the main influencing factor is lysergic acid diethylamide, a semisynthetic derivative of ergot (Claviceps purpurea) that has complex effects on both peripheral and central nervous system serotonergic receptors. Lysergic acid diethylamide is a potent hallucinogen." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0001122 .
obo:XCO_0001124 a rdfs:Class ;
rdfs:label "amiodarone" ;
rdfs:comment "This is any condition in which the main influencing factor is amiodarone, an antianginal and class III antiarrhythmic drug that increases the duration of ventricular and atrial muscle action by inhibiting potassium channels and voltage-gated sodium channels. Following the channel inhibition is a resulting decrease in heart rate and in vascular resistance." ;
rdfs:subClassOf obo:XCO_0000225 , obo:XCO_0000618 .
obo:XCO_0001729 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to gene transfer of the human CYP11A1 gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to gene transfer of the human CYP11A1 gene using an adenovirus vector that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) exposure to gene transfer of the human CYP11A1 gene using an adenovirus vector on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001728 .
obo:XCO_0001056 a rdfs:Class ;
rdfs:label "methylglyoxal" ;
rdfs:comment "This is any condition in which the main influencing factor is methylglyoxal, a 2-oxo aldehyde derived from propanal. Methylglyoxal is an organic compound used often as a reagent in organic synthesis, as a flavoring agent, in tanning and as an experimental antidepressant. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals." ;
rdfs:subClassOf obo:XCO_0000561 .
obo:XCO_0000254 a rdfs:Class ;
rdfs:label "sodium ion solution" ;
rdfs:comment "A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000154 .
obo:XCO_0001434 a rdfs:Class ;
rdfs:label "parasite behavior in a Skinner box within a worker/parasite group feeding/reward paradigm" ;
rdfs:comment "This is any condition in which the main influencing factor is acting as a parasite in a group feeding/reward paradigm in a customized Skinner box, an experimental setup to designed to create parasite-worker social relationships between subjects. The parasite subjects eat most of the rewarded food, while the worker subject performs most of the required lever presses to earn the reward." ;
rdfs:subClassOf obo:XCO_0000491 .
obo:XCO_0000623 a rdfs:Class ;
rdfs:label "tritiated digoxin" ;
rdfs:subClassOf obo:XCO_0000171 , obo:XCO_0000619 .
obo:XCO_0001096 a rdfs:Class ;
rdfs:label "sodium taurocholate" ;
rdfs:comment "This is any condition in which the main influencing factor is sodium taurocholate, the sodium salt of taurocholic acid. Sodium taurocholate is the chief ingredient of the bile of carnivorous animals. It is used experimentally to induce severe acute pancreatitis in laboratory animals." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0001806 a rdfs:Class ;
rdfs:label "transfer of human histone variant H3-3Q5A using a lentivirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is human histone variant H3.3 with a Q5A point mutation which has been (transiently or stably) transferred into a cell or organism using a lentivirus vector in order to induce synthesis of that product in the recipient cell or organism. The Q5A mutation results in a product that cannot be dopaminylated, resulting in downregulation of H3Q5dop." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0000271 a rdfs:Class ;
rdfs:label "antioxidant" ;
rdfs:comment "A substance that opposes oxidation, a reaction in which the atoms in an element lose electrons, and/or inhibits reactions brought about by dioxygen or peroxides." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001848 a rdfs:Class ;
rdfs:label "thermosensitive PLGA-PEG-PLGA hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a thermosensitive hydrogel based on a PLGA-PEG-PLGA (poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,L-lactide-co-glycolide) triblock copolymer, a biomaterial that can induce collagen synthesis." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0001671 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to controlled air ozone oxygen content" ;
rdfs:comment "This is any condition in which the main influencing factor is any parental exposure to controlled air ozone content that has multigenerational effects. This is a condition typically studied to determine the effect of maternal/paternal (F0) controlled air ozone content exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring. Paternal exposure to controlled air ozone content may occur anytime before successful copulation." ;
rdfs:subClassOf obo:XCO_0001670 .
obo:XCO_0001839 a rdfs:Class ;
rdfs:label "Golden Bifid" ;
rdfs:comment "This is any condition in which the main influencing factor is Golden Bifid, a three-strain probiotic combination consisting of Lactobacillus bulgaricus, Bifidobacterium longum, and Streptococcus thermophilus. It is used to regulate the gut microbiota by helping to maintain adequate colonization of the gastrointestinal tract and modulating the composition of the normal microflora." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001784 a rdfs:Class ;
rdfs:label "MyoMed‐205" ;
rdfs:comment "This is any condition in which the main influencing factor is MyoMed-205, a small-molecule inhibitor of MuRF1 (TRIM63/tripartite motif containing 63), a muscle-specific E3 ligase. MyoMed-205 reduces ubiquitination and subsequent proteasomal degradation of muscle proteins by inhibiting MuRF1 activity." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0000150 a rdfs:Class ;
rdfs:label "potassium ion" ;
rdfs:comment "A condition in which the main influencing factor is an atom of potassium, the chemical element with atomic number 19, that has lost one electron, forming a cation with a charge of +1. Potassium is the chief cation of intracellular fluid." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0001378 a rdfs:Class ;
rdfs:label "silicon dioxide nanoparticle" ;
rdfs:comment "This is any condition in which the main influencing factor is a silicon dioxide nanoparticle with a size between 1 and 100 nanometers composed of silicon dioxide. Silicon dioxide is a silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens." ;
rdfs:subClassOf obo:XCO_0000338 , obo:XCO_0001098 .
obo:XCO_0001657 a rdfs:Class ;
rdfs:label "gene transfer of the mouse-jellyfish EGFPL10A fusion gene using an adeno-associated virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of the mouse-jellyfish EGFPL10A (flourescent protein/ribosomal protein) fusion gene using an adeno-associated virus vector. This expression of this vector is double floxed for use with Cre transgenic animals. This vector is used as part a viral TRAP (translating ribosome affinity purification) system to access translating mRNAs." ;
rdfs:subClassOf obo:XCO_0001575 .
obo:XCO_0001682 a rdfs:Class ;
rdfs:label "diazepam" ;
rdfs:comment "This is any condition in which the main influencing factor is diazepam, a 1,4-benzodiazepinone that has a role as a xenobiotic, an environmental contaminant, an anxiolytic drug, an anticonvulsant and a sedative. It is also an organochlorine compound." ;
rdfs:subClassOf obo:XCO_0000950 , obo:XCO_0001122 .
obo:XCO_0000592 a rdfs:Class ;
rdfs:label "cilazapril" ;
rdfs:comment "A prodrug that is hydrolyzed to its main metabolite cilazaprilat, an inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0001775 a rdfs:Class ;
rdfs:label "controlled IDPN content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of IDPN, a colorless liquid used in medical research (neurotoxin) and as a chemical intermediate, consumed by a subject." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000522 a rdfs:Class ;
rdfs:label "common peroneal nerve direct electrical stimulation" ;
rdfs:comment "A condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to the common peroneal nerve(s), for example through the use of microelectrodes or an implanted device. The common peroneal nerve is one of the terminal divisions of the sciatic nerve, diverging from the tibial nerve at the upper end of the popliteal fossa, then coursing with the biceps tendon along the lateral portion of the popliteal space to wind around the neck of the fibula, where it divides into the superficial and deep peroneal nerves." ;
rdfs:subClassOf obo:XCO_0000521 .
obo:XCO_0001769 a rdfs:Class ;
rdfs:label "cannabidiol" ;
rdfs:comment "This is any condition in which the main influencing factor is cannabidiol, a major compound isolated from Cannabis sativa extract that binds to a wide variety of physiological targets of the body's endocannabinoid system. It has shown antimicrobial and anticonvulsant activity, and acts via cytochrome P450 and glucuronosyltransferase inhibition." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000483 , obo:XCO_0000950 .
obo:XCO_0001824 a rdfs:Class ;
rdfs:label "Ward colorectal carcinoma allograft" ;
rdfs:comment "This is any condition in which the main influencing factor is a Ward colorectal carcinoma allograft, in which a piece of solid tumor is transplanted from one animal to another. Ward colorectal carcinoma is a chemically induced tumor in Fischer rats." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0000552 a rdfs:Class ;
rdfs:label "controlled hydralazine content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydralazine in which the amount of hydralazine consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000796 a rdfs:Class ;
rdfs:label "U46619" ;
rdfs:comment "A prostaglandin endoperoxide analogue (11,9 epoxymethano-prostaglandin H2) that is a selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor. It is a stable thromboxane A2 mimetic and a vasoconstrictor." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000962 a rdfs:Class ;
rdfs:label "controlled ex vivo heart perfusion" ;
rdfs:comment "This is an experimental condition consisting of perfusion (retrograde or forward) of the isolated heart with some physiological buffer (consisting of controlled solute composition and specific flow rate) through the aorta. In retrograde perfusion the backwards pressure causes the aortic valve to shut, forcing the solution into the coronary vessels, which normally supply the heart tissue with blood." ;
rdfs:subClassOf obo:XCO_0000961 .
obo:XCO_0000925 a rdfs:Class ;
rdfs:label "bumetanide" ;
rdfs:comment "Bumetanide is a member of the class of benzoic acids, and a diuretic used for treatment of edema associated with congestive heart failure, hepatic and renal disease." ;
rdfs:subClassOf obo:XCO_0000122 .
obo:XCO_0001031 a rdfs:Class ;
rdfs:label "electroacupuncture" ;
rdfs:comment "This is any condition in which the main influencing factor is electroacupuncture, a form of acupuncture where a small electric current is passed between pairs of acupuncture needles. According to some acupuncturists, this practice augments the use of regular acupuncture, can restore health and well-being, and is particularly good for treating pain." ;
rdfs:subClassOf obo:XCO_0001030 .
obo:XCO_0000237 a rdfs:Class ;
rdfs:label "viral pathogen" ;
rdfs:comment "A virus which has the potential to cause disease. A virus is one of a group of heterogeneous infective agents characterized by their lack of independent metabolism, their inability to replicate outside a host cell, their simple organization and their unique mode of replication. A virus consists of genetic material--either DNA or RNA--surrounded by a protein coat and, in some cases, by a membranous envelope." ;
rdfs:subClassOf obo:XCO_0000236 .
obo:XCO_0000783 a rdfs:Class ;
rdfs:label "cytokine" ;
rdfs:comment "This is any condition in which the main influencing factor is a cytokine, a small secreted protein that has a specific effect on the interactions and communications between cells. Cytokine is a general name for other signaling molecules, including lymphokines, monokines, and chemokines." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0000012 a rdfs:Class ;
rdfs:label "controlled air carbon dioxide content" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled air carbon dioxide content surrounding an organism or breathed by the organism as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0000549 a rdfs:Class ;
rdfs:label "left anterior descending coronary artery occlusion" ;
rdfs:comment "A surgical manipulation causing blockage of the left anterior descending coronary artery, the artery supplying blood to approximately half of the left ventricle of the heart including the anterolateral myocardium, apex, and interventricular septum." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0000883 a rdfs:Class ;
rdfs:label "pantoprazole" ;
rdfs:comment "This is a substituted benzimidazole and proton pump inhibitor that is used in the treatment of gastroesophageal reflux and peptic ulcer." ;
rdfs:subClassOf obo:XCO_0000577 .
obo:XCO_0000923 a rdfs:Class ;
rdfs:label "isolated lung perfusion with Hespan buffer" ;
rdfs:comment "This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with Hespan buffer, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle." ;
rdfs:subClassOf obo:XCO_0000875 , obo:XCO_0000877 .
obo:XCO_0000185 a rdfs:Class ;
rdfs:label "calcium ion solution" ;
rdfs:comment "A solution of the divalent cation of calcium, the chemical element with symbol Ca and atomic number 20." ;
rdfs:subClassOf obo:XCO_0000154 .
obo:XCO_0001577 a rdfs:Class ;
rdfs:label "sham gene transfer using an empty AAV1/2 hybrid virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is an empty AAV1/2 hybrid virus vector that has been transferred into a cell or organism. This condition is used as a control for a AAV1/2 hybrid virus transfer of a specific gene." ;
rdfs:subClassOf obo:XCO_0000099 , obo:XCO_0001575 .
obo:XCO_0001139 a rdfs:Class ;
rdfs:label "chloramphenicol" ;
rdfs:comment "This is any condition in which the main influencing factor is chloramphenicol, a topical,broad-spectrum antibiotic first isolated from cultures of Streptomyces venequelae but now produced synthetically. Chloramphenicol act s by interfering with bacterial protein synthesis" ;
rdfs:subClassOf obo:XCO_0000483 .
obo:CHEBI_35679 a rdfs:Class .
obo:XCO_0001114 a rdfs:Class ;
rdfs:label "controlled folic acid content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled folic acid content diet, a solid diet in which the amount of folic acid is maintained at a specified level. Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9." ;
rdfs:subClassOf obo:XCO_0000690 .
obo:XCO_0001672 a rdfs:Class ;
rdfs:label "gestational maternal exposure to controlled air ozone content" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to controlled air ozone content. This is a condition typically studied to determine the effect of maternal (F0) controlled air ozone content exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001671 .
obo:XCO_0001016 a rdfs:Class ;
rdfs:label "minced muscle graft" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a minced muscle graft. It is a surgical procedure intended to induce healing of a skeletal muscle injured by volumetric muscle loss." ;
rdfs:subClassOf obo:XCO_0001859 .
obo:XCO_0000936 a rdfs:Class ;
rdfs:label "left kidney denervation" ;
rdfs:comment "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the left side of the body. It is followed by painting of the left side renal blood vessels with a solution of 10% phenol." ;
rdfs:subClassOf obo:XCO_0000935 .
obo:XCO_0001722 a rdfs:Class ;
rdfs:label "guanine deaminase MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is guanine deaminase presented as multiple antigenic peptides (MAPs), which are four copies of the same peptide epitope synthesized on a lysine-based core (MAPs-4 system)." ;
rdfs:subClassOf obo:XCO_0001710 .
obo:XCO_0000768 a rdfs:Class ;
rdfs:label "Schistosoma mansoni cercariae" ;
rdfs:comment "A condition in which the main influencing factor is the infective cercariae (larvae) of the trematode parasite Schistosoma mansoni." ;
rdfs:subClassOf obo:XCO_0000767 .
obo:XCO_0000045 a rdfs:Class ;
rdfs:label "electromagnetic radiation exposure" ;
rdfs:comment "The condition of being subjected to energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Electromagnetic radiation includes, in order of decreasing wavelength, radio waves, microwaves, infrared, visible, and ultraviolet light, x-rays, gamma rays, and cosmic rays." ;
rdfs:subClassOf obo:XCO_0000038 .
obo:XCO_0000934 a rdfs:Class ;
rdfs:label "bilateral renal denervation" ;
rdfs:comment "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and both kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol." ;
rdfs:subClassOf obo:XCO_0000930 .
obo:XCO_0001382 a rdfs:Class ;
rdfs:label "gestational maternal exposure to metyrapone" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to metyrapone. This is a condition typically studied to determine the effect of maternal (F0) metyrapone use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001381 .
obo:XCO_0000231 a rdfs:Class ;
rdfs:label "anti-RT6.1 antibody" ;
rdfs:comment "Antibody directed against the RT6.1 cell surface alloantigen (also known as ART2, Pta.A2, and Ag-F1). RT6.1 is an allelic form of the RT6 antigen which is expressed on most peripheral T cells but not on thymocytes." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0001045 a rdfs:Class ;
rdfs:label "Walker 256 cells" ;
rdfs:comment "This is any condition in which the main influencing factor is Walker 256, a rat mammary gland carcinoma cell line." ;
rdfs:subClassOf obo:XCO_0000709 .
obo:XCO_0001341 a rdfs:Class ;
rdfs:label "conditioned medium" ;
rdfs:comment "This is any condition in which the main influencing factor is cultured cell-conditioned medium, which consists of the liquid nutrient medium the cells are grown in plus soluble factors secreted by the cells." ;
rdfs:subClassOf obo:XCO_0000965 .
obo:XCO_0001255 a rdfs:Class ;
rdfs:label "indomethacin" ;
rdfs:comment "This is any condition in which the main influencing factor is indomethacin, a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate acute pain and relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis) or gout. Indomethacin also inhibits the motility of polymorphonuclear leukocytes." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0000265 a rdfs:Class ;
rdfs:label "Freund's incomplete adjuvant" ;
rdfs:comment "IFA is used to make a water-in-oil antigen-containing emulsion that lacks the Mycobacteria found in Complete Freund′s Adjuvant so it minimizes the side-effects. It is routinely used for boosting immunizations subsequent to use of Freund's complete adjuvant." ;
rdfs:subClassOf obo:XCO_0000264 .
obo:XCO_0001005 a rdfs:Class ;
rdfs:label "transfer of PIWIL1 siRNA using pSUPER plasmid" ;
rdfs:comment "This is any condition in which the main influencing factor is PIWIL1 (piwi-like RNA-mediated gene silencing 1) siRNA in a pSUPER plasmid. The PIWIL1 protein may play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The pSUPER plasmid was designed for eukaryotic expression/RNAi." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0000492 a rdfs:Class ;
rdfs:label "controlled exposure to a juvenile of the same species" ;
rdfs:comment "This is an experimental condition in which a test subject is placed in social contact with a juvenile (young, not yet mature, not fully grown and/or not fully developed) organism from the same species." ;
rdfs:subClassOf obo:XCO_0000491 .
obo:XCO_0001509 a rdfs:Class ;
rdfs:label "depleted uranium pellet implantation in muscle" ;
rdfs:comment "This is any condition in which the main influencing factor is the surgical implantation of depleted uranium pellet(s) in muscle. Depleted uranium is uranium with a lower content of the fissile isotope 235U than natural uranium. Both depleted uranium and uranium are extremely dense metals." ;
rdfs:subClassOf obo:XCO_0001504 .
obo:XCO_0000793 a rdfs:Class ;
rdfs:label "BTB14431" ;
rdfs:comment "This is an in-silico screening analog of emodin (XCO:0000792)." ;
rdfs:subClassOf obo:XCO_0000435 .
obo:XCO_0000563 a rdfs:Class ;
rdfs:label "Omacor" ;
rdfs:comment "OMACOR is a prescription medicine for adults called a lipid-regulating medicine. It is a mix of docosahexaenoic acid [DHA] (~ 50%) + eicosapentaenoic acid [EPA] (~40%) ethylesters." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0000680 .
obo:XCO_0001691 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to MitoQ-NP" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to MitoQ-NP that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) MitoQ-NP use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001690 .
obo:XCO_0001412 a rdfs:Class ;
rdfs:label "PLA scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a polylactic acid (PLA) scaffold, a tissue scaffold made of Poly(L-Lactic acid) in the form of a nanofiber membrane made by electrospinning. Electrospinning leads to membranes with relatively uniform pore size distribution with high interconnectivity of pores and significantly higher porosity, typically around 80%." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0000771 a rdfs:Class ;
rdfs:label "rat anti-26 kDa antiserum" ;
rdfs:comment "Any condition in which the main influencing factor is serum prepared from rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni." ;
rdfs:subClassOf obo:XCO_0000769 .
obo:XCO_0000999 a rdfs:Class ;
rdfs:label "mechanical ventilation" ;
rdfs:comment "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator. The controlled parameters may be volume, pressure, and/or air component content." ;
rdfs:subClassOf obo:XCO_0000998 .
obo:XCO_0001432 a rdfs:Class ;
rdfs:label "single-pedicled skin flap" ;
rdfs:comment "This is any condition in which the main influencing factor is an autologous, single pedicled skin flap, skin flap in which the flap is still attached to the original blood supply by a single blood vessel. This type of skin flap is relevant in specific clinical situations and in experimental situations for the purpose of studying various factors affecting the success of skin grafts." ;
rdfs:subClassOf obo:XCO_0001053 .
obo:XCO_0000407 a rdfs:Class ;
rdfs:label "hypoglycemic agent" ;
rdfs:comment "This is any condition in which the main influencing factor is a substance which has the ability to lower the level of glucose, particularly blood glucose, in an organism." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0001062 a rdfs:Class ;
rdfs:label "2-hydroxypropyl-β-cyclodextrin" ;
rdfs:comment "This is any condition in which the main influencing factor is 2-hydroxypropyl-β-cyclodextrin, a hydroxypropyl-substituted heptasaccharide made up of a ring of seven glucose subunits joined by α-1,4 glycosidic bonds." ;
rdfs:subClassOf obo:XCO_0001061 .
obo:XCO_0000321 a rdfs:Class ;
rdfs:label "hexamethonium bromide" ;
rdfs:comment "The compound C12H30Br2N2, consisting of a hexamethonium cation and dibromide anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself." ;
rdfs:subClassOf obo:XCO_0000320 .
obo:XCO_0000565 a rdfs:Class ;
rdfs:label "ipragliflozin" ;
rdfs:comment "A pharmaceutical drug for treatment of type 2 diabetes. Ipragliflozin reduces blood glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2." ;
rdfs:subClassOf obo:XCO_0000407 .
obo:XCO_0001385 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to saline" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to saline that has multigenerational effects. This is a vehicle control condition typically studied to control for any effect of maternal (F0) saline (vehicle) use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000101 , obo:XCO_0000156 .
obo:XCO_0001840 a rdfs:Class ;
rdfs:label "experimental urethra injury" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental urethral injury, a penetrating or non-penetrating injury to the urethra resulting from experimentally controlled trauma." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001599 a rdfs:Class ;
rdfs:label "TAK-418" ;
rdfs:comment "This is any condition in which the main influencing factor is TAK-418, a selective, orally active lysine demethylase 1A (KDM1A) enzyme inhibitor. TAK-418 is used to treat autism symptoms in animal models of neurodevelopmental disorders ." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001001 a rdfs:Class ;
rdfs:label "synchronized intermittent mandatory ventilation" ;
rdfs:comment "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with synchronized intermittent mandatory ventilation, meaning the breathing rate is set and the tidal volume is set with pressure support. The subject receives a set minimum number of breaths (the set rate) and any additional breaths are determined by the subject." ;
rdfs:subClassOf obo:XCO_0000999 .
obo:XCO_0000929 a rdfs:Class ;
rdfs:label "controlled ColonLYTELY content drinking water" ;
rdfs:comment "Thia is a drink made up of water and a specified amount of ColonLYTELY (5.9% Macrogol 3350 solution) in which the amount of ColonLYTELY consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001736 a rdfs:Class ;
rdfs:label "uterine tissue autograft" ;
rdfs:comment "This is any condition in which the main influencing factor is a uterine tissue autograft, a transplantation of autologous uterine tissue. This procedure is used as an experimentally induced model of endometriosis in laboratory animals. As an example, the grafted tissue may be removed from the uterine horn and attached to mesenteric arteries supplying the small intestine." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0001813 a rdfs:Class ;
rdfs:label "dihydrotachysterol" ;
rdfs:comment "This is any condition in which the main influencing factor is dihydrotachysterol, a synthetic analog of vitamin D that acts as a bone density conservation agent." ;
rdfs:subClassOf obo:XCO_0000091 , obo:XCO_0000546 .
obo:XCO_0000394 a rdfs:Class ;
rdfs:label "controlled bile acid content diet" ;
rdfs:comment "A regimen of solid food to which a specified amount of bile acid has been added. Bile acids are steroid acids derived from cholesterol in the liver (primary) or produced from primary bile acids by intestinal bacteria (secondary)." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001802 a rdfs:Class ;
rdfs:label "transfer of GalNAc-conjugated ChREBP siRNA" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of ChREBP (carbohydrate-responsive element-binding protein) siRNA conjugated to N-acetylgalactosamine (GalNAc), which allows directed delivery of siRNA to the liver by targeting the asialoglycoprotein receptor." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0000095 a rdfs:Class ;
rdfs:label "bilateral ovariectomy" ;
rdfs:comment "Surgical removal of both ovaries." ;
rdfs:subClassOf obo:XCO_0000094 .
obo:XCO_0000215 a rdfs:Class ;
rdfs:label "controlled calcium ion content physiological salt solution perfusate" ;
rdfs:comment "A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of calcium ions, divalent cations of the metallic chemical element with atomic number 20, dissolved in it." ;
rdfs:subClassOf obo:XCO_0000147 .
obo:XCO_0001094 a rdfs:Class ;
rdfs:label "CFT‐1 tea infusion" ;
rdfs:comment "This is any condition in which the main influencing factor is CFT-1, a green tea variety called Camellia sinensis (L.) O. Kuntze cv. CFT‐1, which is rich in EGCG (antimutagen epigallocatechin-3-gallate)." ;
rdfs:subClassOf obo:XCO_0000075 .
obo:XCO_0000912 a rdfs:Class ;
rdfs:label "controlled exposure to red light" ;
rdfs:comment "Condition in which the environmental level and/or time of exposure to red light (wavelength range of 630740 nm) is controlled." ;
rdfs:subClassOf obo:XCO_0000284 .
obo:XCO_0000146 a rdfs:Class ;
rdfs:label "controlled oxygen content Kreb's solution perfusate" ;
rdfs:comment "A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source in which a specified amount of the tasteless, odorless, colorless gas essential for aerobic respiration with atomic number 8 has been dissolved, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." ;
rdfs:subClassOf obo:XCO_0000116 .
obo:XCO_0000415 a rdfs:Class ;
rdfs:label "maternal milk" ;
rdfs:comment "This is any condition in which the main influencing factor is maternal milk, the nutrient fluid produced by the mammary gland of a female mammal for the nourishment of her young and consumed by her offspring or a fosterling of the same species." ;
rdfs:subClassOf obo:XCO_0000416 .
obo:XCO_0000914 a rdfs:Class ;
rdfs:label "cafeteria diet" ;
rdfs:comment "A dietary regimen in which access to food is unlimited and consists of energy-dense, highly palatable food. The diet is technically undefined as to ratio of components, but recapitulates the orosensory properties (such as smell and texture) and palatability of foodstuffs that promote overconsumption (voluntary hyperphagia). It has been proven to not only increase body weight and induce obesity, but to also cause metabolic syndrome, severe diabetic symptoms, liver inflammation, and other metabolic dysregulations." ;
rdfs:subClassOf obo:XCO_0000019 .
obo:XCO_0000354 a rdfs:Class ;
rdfs:label "N-methyl-N'-nitro-N-nitrosoguanidine" ;
rdfs:comment "A guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000205 .
obo:XCO_0001298 a rdfs:Class ;
rdfs:label "bleomycin" ;
rdfs:comment "This is any condition in which the main influencing factor is bleomycin, a complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. Bleomycin inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000482 .
obo:XCO_0000582 a rdfs:Class ;
rdfs:label "obsolete controlled content oral gavage" ;
rdfs:comment "OBSOLETE. Oral gavage in which the amount of one or more solutes are adjusted to a requirement." .
obo:XCO_0001588 a rdfs:Class ;
rdfs:label "gestational maternal exposure to ITE" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to ITE (2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester). This is a condition typically studied to determine the effect of maternal (F0) ITE use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001587 .
obo:XCO_0000931 a rdfs:Class ;
rdfs:label "celiac artery and superior mesenteric artery constriction" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical narrowing of the lumen of the celiac artery and superior mesenteric artery." ;
rdfs:subClassOf obo:XCO_0000596 .
obo:XCO_0000168 a rdfs:Class ;
rdfs:label "controlled in situ renal perfusion pressure" ;
rdfs:comment "Condition in which the difference in pressure between the arteries and veins in the kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally regulated, for example by injecting or pumping a fluid into the kidney at a specified pressure or by regulating the blood flow through the kidney, without removal of the organ from the body." ;
rdfs:subClassOf obo:XCO_0000167 .
obo:XCO_0001761 a rdfs:Class ;
rdfs:label "Shengyu decoction" ;
rdfs:comment "This is any condition in which the main influencing factor is Shengyu decoction, a combination of seven different herbal medicines. Shengyu decoction has been used in traditional Chinese medicine (TCM) to treat cardiovascular and brain-related disorders." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000356 a rdfs:Class ;
rdfs:label "spinal cord homogenate" ;
rdfs:comment "A condition in which the major contributing factor is a preparation of spinal cord which has been rendered uniform in structure and/or composition throughout, for example by grinding the tissue until it has been reduced to particles which are evenly distributed thoughout a fluid. Spinal cord is the long, flexible, nearly cylindric structure of nerve tissue that extends from the medulla oblongata down through the vertebral canal and from which the spinal nerves branch off to various parts of the body." ;
rdfs:subClassOf obo:XCO_0000133 .
obo:XCO_0001067 a rdfs:Class ;
rdfs:label "nitroglycerin" ;
rdfs:comment "This is any condition in which the main influencing factor is nitroglycerin, a volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. It is also sometimes used for tocolysis." ;
rdfs:subClassOf obo:XCO_0000140 .
obo:XCO_0001523 a rdfs:Class ;
rdfs:label "maternal exposure to controlled air oxygen content during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to controlled air oxygen content during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) controlled air oxygen content exposure during the postnatal, preweaning period on the F1 offspring ." .
obo:XCO_0000110 a rdfs:Class ;
rdfs:label "prone position" ;
rdfs:comment "A position in which the organism is lying face down." ;
rdfs:subClassOf obo:XCO_0000081 .
obo:XCO_0001074 a rdfs:Class ;
rdfs:label "ureter ligation" ;
rdfs:comment "This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one or both ureters. Ureters are the muscular ducts that propel urine from the kidneys to the urinary bladder." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001705 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to stress induced phosphoprotein 1 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to an autoantibody-generating level of stress induced phosphoprotein 1 (STIP1) multiple antigenic peptides (MAPs) that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) STIP1 exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001721 .
obo:XCO_0000377 a rdfs:Class ;
rdfs:label "vitamin" ;
rdfs:comment "A condition in which the main influencing factor is any of a group of unrelated organic substances occurring in many foods in small amounts and necessary in trace amounts for the normal metabolic functioning of the body." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001027 a rdfs:Class ;
rdfs:label "gene transfer of the Rpl10a gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the Rpl10a (ribosomal protein L10A) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rpl10a in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0000677 a rdfs:Class ;
rdfs:label "controlled enalapril content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of enalapril consumed by an organism as part of an experiment. Enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000739 a rdfs:Class ;
rdfs:label "housing in trios" ;
rdfs:comment "This is any condition in which the main influencing factor is housing in trios, a sutuation where subjects are housed in groups of three during a specified time period(s)." ;
rdfs:subClassOf obo:XCO_0000033 .
obo:XCO_0001539 a rdfs:Class ;
rdfs:label "sham gene transfer using an empty lentivirus vector" ;
rdfs:comment "This is any condition in which the major influencing factor is an empty lentivirus vector that has been transferred into a cell or organism. This condition is used as a control for a lentivirus transfer of a specific gene." ;
rdfs:subClassOf obo:XCO_0000099 , obo:XCO_0000982 .
obo:XCO_0000192 a rdfs:Class ;
rdfs:label "deoxycorticosterone acetate" ;
rdfs:comment "The acetate ester of 11-deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone." ;
rdfs:subClassOf obo:XCO_0000330 .
obo:XCO_0001650 a rdfs:Class ;
rdfs:label "controlled leucine content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of leucine consumed by an organism as part of an experiment. Leucine is a branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001371 a rdfs:Class ;
rdfs:label "Ancr/E7 exosome-modified TEBV implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is Ancr/E7 exosome-modified TEBV implantation, which is the replacement of a blood vessel with a tissue-engineered blood vessel incorporating Ancr/E7 exosomes." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0000844 a rdfs:Class ;
rdfs:label "sodium phenobarbital" ;
rdfs:comment "This is any condition in which the main influencing factor is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). Sodium phenobarbital is an acvtivator of the constitutive androstane receptor (CAR; Nr1i3)." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000511 a rdfs:Class ;
rdfs:label "ester" ;
rdfs:comment "Any condition in which the main influencing factor is a substance is a chemical compound derived from the linkage of an organic or inorganic acid and an alcohol, phenol, heteroarenol, or enol with the loss of water (H2O) formed from one hydrogen derived from an acidic hydroxy group of the acid and an -OH (hydroxy) group of the alcohol." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000526 a rdfs:Class ;
rdfs:label "swimming with water weights" ;
rdfs:comment "A condition in which the main influencing factor is the action of moving one's appendages to propel oneself through water while carrying weights (for example, aquatic dumbbells, ankle cuffs, or weighted belt) to increase resistance and/or decrease buoyancy thereby increasing the difficulty of the action." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0000721 a rdfs:Class ;
rdfs:label "eprosartan" ;
rdfs:comment "This is any condition whose main influencing factor is eprosartan, a member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure." ;
rdfs:subClassOf obo:XCO_0000536 .
obo:XCO_0000613 a rdfs:Class ;
rdfs:label "adenosine triphosphate" ;
rdfs:comment "Adenosine Triphosphate (ATP) is an adenine nucleotide comprised of three phosphate groups esterified to the sugar moiety, found in all living cells. Adenosine triphosphate is involved in energy production for metabolic processes and RNA synthesis. In addition, this substance acts as a neurotransmitter. In cancer studies, adenosine triphosphate is synthesized to examine its use to decrease weight loss and improve muscle strength." ;
rdfs:subClassOf obo:XCO_0000392 .
obo:XCO_0000951 a rdfs:Class ;
rdfs:label "2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline" ;
rdfs:comment "This is a condition in which the main influencing factor is an AMPA and KA receptor antagonist and a neuroprotectant for cerebral ischemia." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0000950 .
obo:XCO_0000447 a rdfs:Class ;
rdfs:label "estrus" ;
rdfs:comment "A regularly recurrent state of sexual excitability during which the female of non-primate mammalian species will accept the male and is capable of conceiving." .
obo:XCO_0001528 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to citrate buffer" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to citrate buffer that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) citrate buffer exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring. Citrate buffer is a combination of sodium citrate dihydrate and citric acid in water to form a solution with a pH range of 3.0 to 6.2." ;
rdfs:subClassOf obo:XCO_0000101 , obo:XCO_0001464 .
obo:XCO_0000253 a rdfs:Class ;
rdfs:label "sodium ion" ;
rdfs:comment "This is any condition in which the main influencing factor is an ion of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0000226 a rdfs:Class ;
rdfs:label "apamin" ;
rdfs:comment "An 18 amino acid peptide neurotoxin from bee venom which blocks small-conductance Ca2+-activated K+ channels." ;
rdfs:subClassOf obo:XCO_0000225 .
obo:XCO_0001218 a rdfs:Class ;
rdfs:label "controlled ampicillin content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of ampicillin, a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000688 a rdfs:Class ;
rdfs:label "myelin basic protein" ;
rdfs:comment "Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Myelin basic protein may constitute as much as one-third of all protein in myelin." ;
rdfs:subClassOf obo:XCO_0000260 , obo:XCO_0000292 .
obo:XCO_0000530 a rdfs:Class ;
rdfs:label "gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector" ;
rdfs:comment "A condition in which the mouse angiotensin I converting enzyme 2 (Ace2) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0001307 a rdfs:Class ;
rdfs:label "experimental muscle contusion" ;
rdfs:comment "This is a condition induced by an mechanical procedure involving controlled trauma to skeletal muscle, such as the vastus medialis (part of the quadriceps muscle). Controlled muscle contusion has been used to model myofascial pain syndrome and other skeletal muscle injuries." ;
rdfs:subClassOf obo:XCO_0001306 .
obo:XCO_0000872 a rdfs:Class ;
rdfs:label "thymosin alpha-1" ;
rdfs:comment "This is any condition in which the main influencing factor is thymosin alpha-1, a member of a family of heat-stable, polypeptide hormones secreted by the thymus gland. Thymosins are immune response-modulating molecules." ;
rdfs:subClassOf obo:XCO_0000228 , obo:XCO_0000483 , obo:XCO_0000657 .
obo:XCO_0001689 a rdfs:Class ;
rdfs:label "mitoquinone" ;
rdfs:comment "This is any condition in which the main influencing factor is mitoquinone, a synthetic analogue of coenzyme Q10 which has antioxidant effects. The Mitoquinone molecule is based on a novel technology, targeted lipophilic cations, that transport and concentrate antioxidants into the mitochondria, where they accumulate up to a thousand fold." ;
rdfs:subClassOf obo:XCO_0000271 .
obo:XCO_0001797 a rdfs:Class ;
rdfs:label "uterine curettage" ;
rdfs:comment "This is any condition in which the main influencing factor is uterine curettage, the surgical scraping of the lining of the uterus performed using a curette, a scoop- or hoe-shaped instrument that may be blunt or sharp." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001747 a rdfs:Class ;
rdfs:label "left carotid artery occlusion sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a left carotid artery occlusion sham procedure, which follows the same surgical process as a left common carotid artery occlusion without blocking the left common carotid artery or any other arteries." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0001744 a rdfs:Class ;
rdfs:label "sham gene transfer using an empty plasmid vector" ;
rdfs:comment "This is any condition in which the major influencing factor is an empty plasmid vector has been transferred (transiently or stably) into a cell or organism. This condition is used as a control for a plasmid transfer of a specific gene." ;
rdfs:subClassOf obo:XCO_0000099 , obo:XCO_0000818 .
obo:XCO_0000388 a rdfs:Class ;
rdfs:label "acetaminophen" ;
rdfs:comment "Condition in which the main influencing factor is acetaminophen, an analgesic and antipyretic with effects similar to aspirin but only weakly antiinflammatory." ;
rdfs:subClassOf obo:XCO_0000106 .
obo:XCO_0000627 a rdfs:Class ;
rdfs:label "spironolactone" ;
rdfs:comment "Any condition in which the main influencing factor is spironolactone, a potassium-sparing diuretic that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone is indicated to treat a number of conditions including heart failure, edema, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome." ;
rdfs:subClassOf obo:XCO_0000122 , obo:XCO_0000838 .
obo:XCO_0000714 a rdfs:Class ;
rdfs:label "SB-239063" ;
rdfs:comment "A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively. It is a mitogen-activated protein kinase inhibitor." ;
rdfs:subClassOf obo:XCO_0000715 .
obo:XCO_0000313 a rdfs:Class ;
rdfs:label "lithium ion" ;
rdfs:comment "A condition in which the main influencing factor is an atom of lithium, the chemical element with atomic number 3, that has lost one electron, forming a cation with a charge of +1." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0001787 a rdfs:Class ;
rdfs:label "extracorporeal circulating blood transfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is extracorporeal circulating blood transfusion, the continuous intravenous reinfusion of blood into the same individual from whom it was removed." ;
rdfs:subClassOf obo:XCO_0001297 .
obo:XCO_0000838 a rdfs:Class ;
rdfs:label "mineralocorticoid receptor antagonist" ;
rdfs:comment "Any condition in which the main influencing factor is an agent that blocks the mineralocorticoid (primarily aldosterone) receptor (NR3C2), which regulates water and electrolyte metabolism." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001281 a rdfs:Class ;
rdfs:label "sodium octanoate" ;
rdfs:comment "This is any condition in which the main influencing factor is sodium octanoate, an organic sodium salt comprising equal numbers of sodium and octanoate ions." .
obo:XCO_0000293 a rdfs:Class ;
rdfs:label "99mTc-sestamibi" ;
rdfs:comment "A coordination complex of technetium-99m, a radioisotope of the chemical element technetium, atomic number 43, a gamma emitter having a half-life of approximately 6 hours, and methoxyisobutylisonitrile (MIBI), a lipophilic cation, used as an agent in nuclear medicine imaging." ;
rdfs:subClassOf obo:XCO_0000171 .
obo:XCO_0000861 a rdfs:Class ;
rdfs:label "control IgG monoclonal antibody" ;
rdfs:comment "A condition in which the main influencing factor is an isotype-matched (IgG) monoclonal antibody to provide a control for some target-specific monoclonal antibody." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0001034 a rdfs:Class ;
rdfs:label "hawk tea extract" ;
rdfs:comment "This is any condition in which the main influencing factor is hawk tea extract (HTE), a potential cholesterol-lowering agent and antioxidant. Hawk tea is a medicinal herbal and caffeine-free drink popular in China." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000680 .
obo:XCO_0000484 a rdfs:Class ;
rdfs:label "ceftriaxone" ;
rdfs:comment "This is any condition in which the main influencing factor is ceftriaxone, a third-generation cephalosporin antibacterial agent with broad-spectrum activity against both Gram-positive and Gram-negative bacteria." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0001660 a rdfs:Class ;
rdfs:label "C75" ;
rdfs:comment "This is any condition in which the main influencing factor is C75, a fatty acid synthase (FASN) inhibitor and an activator of carnitine palmitoyl-transferase-1 (CPT1A). C75 has shown potential therapeutic effects in several cancer models." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000523 , obo:XCO_0000694 .
obo:XCO_0000157 a rdfs:Class ;
rdfs:label "physical restraint" ;
rdfs:comment "The use of manual or mechanical means to limit some or all of an animal's normal movement for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation." ;
rdfs:subClassOf obo:XCO_0001100 .
obo:XCO_0001755 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to fentanyl" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to fentanyl that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) fentanyl use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001754 .
obo:XCO_0001111 a rdfs:Class ;
rdfs:label "mercury dichloride" ;
rdfs:comment "This is any condition in which the main influencing factor is mercury dichloride, a mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, its use has markedly declined as less toxic alternatives have been developed." ;
rdfs:subClassOf obo:XCO_0001112 , obo:XCO_0001549 .
obo:XCO_0000127 a rdfs:Class ;
rdfs:label "norepinephrine" ;
rdfs:comment "A catecholamine neurotransmitter and stress hormone with multiple physiological roles including affects on heart rate, blood pressure and vascular tone." ;
rdfs:subClassOf obo:XCO_0000141 , obo:XCO_0000144 , obo:XCO_0000230 .
obo:XCO_0000135 a rdfs:Class ;
rdfs:label "receptor agonist" ;
rdfs:comment "A drug or other chemical that can combine with a receptor to produce a physiologic reaction typical of a naturally occurring substance. A receptor is a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect in the cell." ;
rdfs:subClassOf obo:XCO_0000214 .
obo:XCO_0000920 a rdfs:Class ;
rdfs:label "controlled mineral content diet" ;
rdfs:comment "A regimen of solid food in which the amount of an inorganic element or compound containing a metal, nonmetal, radical, or phosphate that is needed for proper body function and maintenance of health, is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001610 a rdfs:Class ;
rdfs:label "maternal exposure to standard rat chow diet during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to standard rat chow diet during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) standard rat chow diet exposure during the postnatal, preweaning period on the F1 offspring." .
obo:XCO_0001128 a rdfs:Class ;
rdfs:label "polysaccharide derivative" ;
rdfs:comment "This is any condition in which the main influencing factor is a polysaccharide derivative, a carbohydrate derivative that is any derivative of a polysaccharide (a biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically). Various molecules can be covalently attached to the hydroxyl groups of polysaccharides and thus form polysaccaride derivatives." ;
rdfs:subClassOf obo:XCO_0000173 .
obo:XCO_0001083 a rdfs:Class ;
rdfs:label "imperatorin" ;
rdfs:comment "This is any condition in which the main influencing factor is imperatorin, a member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001287 a rdfs:Class ;
rdfs:label "hot plate stimulus" ;
rdfs:comment "This is any condition in which the main influencing factor is a hot plate stimulus, usually encountered by laboratory rodents in thermal hyperalgesia testing. The hot plate test is a useful screening tool for interventions of analgesia and involves placing the subject on its feet on a temperature-regulatable hot plate inside a cylindrical chamber." ;
rdfs:subClassOf obo:XCO_0000052 .
obo:XCO_0001393 a rdfs:Class ;
rdfs:label "human stem cells" ;
rdfs:comment "This is a condition in which the main influencing factor is a human stem cell, an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions." ;
rdfs:subClassOf obo:XCO_0000851 .
obo:XCO_0001506 a rdfs:Class ;
rdfs:label "nickel pellet implantation in muscle" ;
rdfs:comment "This is any condition in which the main influencing factor is the surgical implantation of nickel pellet(s) in muscle. Nickel is a hard and ductile transition metal that is used in various metal alloys." ;
rdfs:subClassOf obo:XCO_0001504 .
obo:XCO_0000616 a rdfs:Class ;
rdfs:label "verapamil" ;
rdfs:comment "Verapamil is a calcium channel blocker that is a class IV anti-arrhythmia agent." ;
rdfs:subClassOf obo:XCO_0000269 .
obo:XCO_0000080 a rdfs:Class ;
rdfs:label "tobacco chewing" ;
rdfs:comment "Mastication of a form of the prepared leaves of Nicotiana tabacum that is chewed." ;
rdfs:subClassOf obo:XCO_0000077 .
obo:XCO_0001534 a rdfs:Class ;
rdfs:label "peripheral nerve allograft" ;
rdfs:comment "This is any condition in which the main influencing factor is a peripheral nerve allograft, a non-self peripheral nerve transplantation, typically without histocompatibility matching between donor and host. Commonly, a portion of a donor nerve replaces the damaged portion of the host nerve and involves neurorrhaphy (re-apposing the cut ends with epineurial microsutures)." ;
rdfs:subClassOf obo:XCO_0001860 .
obo:XCO_0001725 a rdfs:Class ;
rdfs:label "collapsin response mediator protein 1 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is collapsin response mediator protein 1 (CRMP1) presented as multiple antigenic peptides (MAPs), which are four copies of the same peptide epitope synthesized on a lysine-based core (MAPs-4 system)." ;
rdfs:subClassOf obo:XCO_0001699 .
obo:XCO_0000973 a rdfs:Class ;
rdfs:label "sorafenib" ;
rdfs:comment "This is any condition in which the main influencing factor is the chemical sorafenib, a member of the class of phenylureas that are multi-kinase inhibitors and anti-neoplastic agents." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000970 .
obo:XCO_0001330 a rdfs:Class ;
rdfs:label "oxycodone" ;
rdfs:comment "This is any condition in which the main influencing factor is oxycodone, a semisynthetic opioid analgesic derived from thebaine." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0001329 .
obo:XCO_0000596 a rdfs:Class ;
rdfs:label "blood vessel constriction" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical narrowing of the lumen of a blood vessel. This lumen narrowing could be accomplished by circumferential suturing, use of a manipulatable sleeve, or some other method." ;
rdfs:subClassOf obo:XCO_0000595 .
obo:XCO_0000248 a rdfs:Class ;
rdfs:label "kidney transplant" ;
rdfs:comment "A surgical procedure in which one or both kidneys from a donor organism are implanted into a recipient organism." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0000988 a rdfs:Class ;
rdfs:label "Dulbecco's Modified Eagle's Medium" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is Dulbecco's Modified Eagle's Medium. Typically, cells derived from a multicellular organism are cultured in this synthetic medium originally formulated by Dulbecco and Freeman and based on Eagle's Minimal Essential Medium." ;
rdfs:subClassOf obo:XCO_0000966 .
obo:XCO_0000491 a rdfs:Class ;
rdfs:label "controlled exposure to an organism of the same species" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled social contact with an organism from the same species. A species is a fundamental category of taxonomic classification, ranking below a genus and consisting of related organisms capable of interbreeding." ;
rdfs:subClassOf obo:XCO_0000489 .
obo:XCO_0000817 a rdfs:Class ;
rdfs:label "whole thorax lung irradiation" ;
rdfs:comment "Whole thorax lung irradiation is a type of partial body irradiation used to target the lungs. In experimental animals it is used to study the lung morbidities caused by radiation exposure." ;
rdfs:subClassOf obo:XCO_0000814 .
obo:XCO_0001401 a rdfs:Class ;
rdfs:label "Xiaogu San" ;
rdfs:comment "This is any condition in which the main influencing factor is Xiaogu San, a multi-herbal composition (traditional chinese medicine formula) which contains components commonly prescribed in the treatment of pain and inflammation.." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0001012 a rdfs:Class ;
rdfs:label "gene transfer of the rat Rbpms gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the rat Rbpms (RNA binding protein, mRNA processing factor) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rbpms in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0000090 a rdfs:Class ;
rdfs:label "7,12-dimethyltetraphene" ;
rdfs:comment "A tetraphene having methyl substituents at the 7- and 12- positions. It is a potent carcinogen and is present in tobacco smoke." ;
rdfs:subClassOf obo:XCO_0000093 .
obo:XCO_0000366 a rdfs:Class .
obo:XCO_0000116 a rdfs:Class ;
rdfs:label "Kreb's solution perfusate" ;
rdfs:comment "A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." ;
rdfs:subClassOf obo:XCO_0000115 .
obo:XCO_0000800 a rdfs:Class ;
rdfs:label "iron oxide nanoparticle" ;
rdfs:comment "This is any condition in which the main influencing factor is a particle with a size between 1 and 100 nanometers composed of iron oxide (Fe3O4). It contains both Fe2+ and Fe3+ ions and is sometimes formulated as FeO ? Fe2O3. It exhibits permanent magnetism and is ferrimagnetic." ;
rdfs:subClassOf obo:XCO_0000338 .
obo:XCO_0001269 a rdfs:Class ;
rdfs:label "forced swimming" ;
rdfs:comment "This is any condition in which the main influencing factor is forced swimming, a situation in which the subject (typically a laboratory rodent) inside a water-filled chamber must swim to survive." ;
rdfs:subClassOf obo:XCO_0000006 .
obo:XCO_0001765 a rdfs:Class ;
rdfs:label "hydroxyurea" ;
rdfs:comment "This is any condition in which the main influencing factor is hydroxyurea, an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea is used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease." ;
rdfs:subClassOf obo:XCO_0000390 , obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0000426 a rdfs:Class ;
rdfs:label "1H-pyrazole" ;
rdfs:comment "This is any condition in which the main influencing factor is 1H-pyrazole, a heterocyclic organic compound with the formula C3H3N2H which is a 5-membered ring of three carbon atoms and two adjacent nitrogen centers, i.e., with nitrogens at positions 1 and 2 of the ring. 1H-pyrazole is a tautomer of 3H-pyrazole and 4H-pyrazole. Pyrazole is a core motif in many antioxidant molecules." .
obo:XCO_0000757 a rdfs:Class ;
rdfs:label "surfactant" ;
rdfs:comment "A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapor and/or at other interfaces." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001494 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to bisphenol A" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to bisphenol A that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) bisphenol A use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000397 .
obo:XCO_0001758 a rdfs:Class ;
rdfs:label "maternal exposure to fentanyl during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to fentanyl during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) fentanyl use/exposure during the postnatal, preweaning period on the F1 offspring.\"" ;
rdfs:subClassOf obo:XCO_0001755 .
obo:XCO_0001835 a rdfs:Class ;
rdfs:label "celecoxib" ;
rdfs:comment "This is any condition in which the main influencing factor is celecoxib, a cyclooxygenase-2 inhibitor used in the treatment of arthritis. It functions as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0000576 a rdfs:Class ;
rdfs:label "controlled meropenem content drinking water" ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001244 a rdfs:Class ;
rdfs:label "ambient environment" ;
rdfs:comment "This is any condition in which the major influencing factor is the ambient environment, an encompassing atmosphere which includes temperature, light, sound, and air content as parameters." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000587 a rdfs:Class ;
rdfs:label "intracerebroventricular cannula implantation" ;
rdfs:comment "Stereotaxic implant with a stainless steel cannula into a cerebral ventricle, which can be connected via silastic tubing to a miniosmotic pump for chronic infusion." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0001449 a rdfs:Class ;
rdfs:label "hepatotoxic chemical" ;
rdfs:comment "This is any condition in which the main influencing factor is a hepatotoxic chemical, a chemical that causes injury to or disease of the liver." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0001023 a rdfs:Class ;
rdfs:label "controlled flaxseed oil content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a solid diet in which the amount of flaxseed oil, an edible oil rich in α-Linolenic acid (an omega-3 fatty acid), is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000454 .
obo:XCO_0000515 a rdfs:Class ;
rdfs:label "metoprolol tartrate" ;
rdfs:comment "A condition in which the main influencing factor is metoprolol tartrate, an immediate-release formulation of metoprolol. Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches." ;
rdfs:subClassOf obo:XCO_0000514 .
obo:XCO_0000736 a rdfs:Class ;
rdfs:label "diphtheria toxin" ;
rdfs:comment "An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that can cause a localized infection of mucous membranes or skin (diphtheria), myocarditis, polyneuritis, and other systemic toxic effects." ;
rdfs:subClassOf obo:XCO_0000240 .
obo:XCO_0000451 a rdfs:Class ;
rdfs:label "Herpes simplex virus type 1" ;
rdfs:comment "A condition in which the main influencing factor is a neurotropic virus that is a member of the Herpesviridae family and that, once the infection becomes chronic, has the ability to cycle through recurring outbreak periods followed by periods of latency or dormancy in which the virus is inactive but still present in infected nerve cells. HSV1 causes primarily mouth, throat, face, eye, and central nervous system infections." ;
rdfs:subClassOf obo:XCO_0000237 .
obo:XCO_0000376 a rdfs:Class ;
rdfs:label "saphenous nerve axotomy" ;
rdfs:comment "Surgical transection or severing of one or more axons of the saphenous nerve, a sensory nerve that is a terminal branch of the femoral nerve, in humans extending from the femoral triangle to the foot, becoming subcutaneous on the medial side of the knee." ;
rdfs:subClassOf obo:XCO_0000374 .
obo:XCO_0000907 a rdfs:Class ;
rdfs:label "liraglutide" ;
rdfs:comment "Any condition in which the main influencing factor is liraglutide, a lipopeptide that is an analogue of human GLP-1 and an agonist of the GLP-1 receptor. Liraglutide is used as a hypoglycemic agent and supplemental therapy in the treatment of diabetes mellitus." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000407 .
obo:XCO_0000210 a rdfs:Class ;
rdfs:label "partial hepatectomy" ;
rdfs:comment "A condition involving the surgical excision of part of the liver, the large abdominal organ/gland which functions in the storage and filtration of blood, secretion of bile, and other processes. The partial liver removal may be minor (< 50%) or major (> 50%)." ;
rdfs:subClassOf obo:XCO_0000209 .
obo:XCO_0000120 a rdfs:Class ;
rdfs:label "inhibitor" ;
rdfs:comment "A substance or compound which interferes with a chemical reaction or a molecular or physiological process or activity." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000324 a rdfs:Class ;
rdfs:label "primary alcohol" ;
rdfs:comment "Any condition in which the main influencing factor is a primary alcohol, a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." ;
rdfs:subClassOf obo:XCO_0000323 .
obo:XCO_0000073 a rdfs:Class ;
rdfs:label "liquor" ;
rdfs:comment "Alcoholic beverage produced by distillation." ;
rdfs:subClassOf obo:XCO_0000070 .
obo:XCO_0000205 a rdfs:Class ;
rdfs:label "mutation inducing chemical" ;
rdfs:comment "An agent that causes or increases the frequency of permanent, heritable changes in the DNA sequence or chromosomal structure of a cell or organism." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000811 a rdfs:Class ;
rdfs:label "A23187" ;
rdfs:comment "This is any condition in which the main influencing factor is A23187, an ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000482 , obo:XCO_0000890 .
obo:XCO_0001110 a rdfs:Class ;
rdfs:label "d-SMG" ;
rdfs:comment "This is any condition in which the main influencing factor is dried snail-mucus gel (SMG), a natural substance derived from mucus harvested from snails (Achatina fulica or Helix lucorum). The chemical composition of SMG includes a high percentage of heparin-like glycosaminoglycan." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001798 a rdfs:Class ;
rdfs:label "gelatin hydrogel scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a hydrogel scaffold in which gelatin is used as the cross-linked polymer. Gelatin hydrogels have a wide range of applications, including tissue engineering and drug delivery." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0001795 a rdfs:Class ;
rdfs:label "shallow water walking" ;
rdfs:comment "This is any condition in which the main influencing factor is walking in shallow water, in which the feet touch the bottom. The water provides buoyancy, reducing pressure on the joints, and resistance." ;
rdfs:subClassOf obo:XCO_0000007 .
obo:XCO_0000181 a rdfs:Class ;
rdfs:label "controlled visible light condition" ;
rdfs:comment "Condition in which the presence or absence of visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is constrained." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000956 a rdfs:Class ;
rdfs:label "artificial cerebrospinal fluid with 0.14 M sodium" ;
rdfs:comment "This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.14 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid." ;
rdfs:subClassOf obo:XCO_0000830 .
obo:XCO_0001052 a rdfs:Class ;
rdfs:label "5-aza-2′-deoxycytidine" ;
rdfs:comment "This is any condition in which the main influencing factor is a 2'-deoxyribonucleoside that has formula C8H12N4O4. 5-aza-2′-deoxycytidine is a chemotherapeutic pyrimidine nucleoside analogue that integrates into cellular DNA and inhibits the action of DNA methyltransferases." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0001421 a rdfs:Class ;
rdfs:label "liver transplant" ;
rdfs:comment "This is any condition in which the main influencing factor is a liver transplant, a surgical procedure in which a whole or partial liver from a donor organism is implanted into a recipient organism for the clinical purpose of replacing a diseased liver or for the experimental purpose of studying organ transplantation." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0000602 a rdfs:Class ;
rdfs:label "rosiglitazone" ;
rdfs:comment "A peroxisome proliferator-activated receptor gamma agonist; reduces lipid availability, improves insulin action & glucoregulation" ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000407 .
obo:XCO_0001251 a rdfs:Class ;
rdfs:label "Alismatis rhizoma" ;
rdfs:comment "This is any condition in which the main influencing factor is Alismatis rhizoma, the rhizomes of A. orientale (Alisma orientale, a flowering plant species found in Asia) which have been used as a traditional Chinese medicine and as a kampo Japanese medicine. Terpenoids have been identified as characteristic constituents of Alisma orientale." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000282 a rdfs:Class ;
rdfs:label "anti-Thy1 antibody" ;
rdfs:comment "An immunoglobulin molecule having a specific amino acid sequence that gives it the ability to adhere to and interact only with Thy1, i.e. Thymocyte antigen 1, and molecules containing structures similar to that antigen. Thy1, also known as CD90, is a 25-37 kDa, heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored, conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen and now known to be the smallest member of the immunoglobulin superfamily of proteins." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0000436 a rdfs:Class ;
rdfs:label "controlled N-propyl-N-nitrosourea content diet" ;
rdfs:comment "A solid diet in which the amount of N-propyl-N-nitrosourea (PNU) is maintained at a specified level. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000533 a rdfs:Class ;
rdfs:label "puromycin" ;
rdfs:comment "Condition in which the main influencing factor is puromycin, an aminonucleoside antibiotic derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000482 , obo:XCO_0000532 .
obo:XCO_0001041 a rdfs:Class ;
rdfs:label "experimental spinal cord contusion" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy and delivery of a controlled contusion of the spinal cord by a mechanical apparatus." ;
rdfs:subClassOf obo:XCO_0001091 .
obo:XCO_0000699 a rdfs:Class ;
rdfs:label "controlled GSK2181236A content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled GSK2181236A content diet, a regimen of solid food in which the amount of GSK2181236A consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001318 a rdfs:Class ;
rdfs:label "motor cortex stimulation via implanted electrode array" ;
rdfs:comment "This is any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to a specific area of motor cortex. This is done with implanted electrode(s)." ;
rdfs:subClassOf obo:XCO_0000027 , obo:XCO_0000520 .
obo:XCO_0000918 a rdfs:Class ;
rdfs:label "ambient air" ;
rdfs:comment "This is any condition in which the major influencing factor is atmospheric air in its natural state. The composition of ambient air varies depending on the elevation above sea level, but is typically 78% nitrogen and 21% oxygen." .
obo:XCO_0000242 a rdfs:Class ;
rdfs:label "alloxan" ;
rdfs:comment "A condition in which the main influencing factor is alloxan, an oxygenated pyrimidine derivative which is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling type 1 diabetes mellitus through destruction of the beta cells." ;
rdfs:subClassOf obo:XCO_0000239 , obo:XCO_0000885 .
obo:XCO_0000221 a rdfs:Class ;
rdfs:label "ion channel inhibitor" ;
rdfs:comment "Any chemical substance which decreases or interferes with the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0001437 a rdfs:Class ;
rdfs:label "duodenal-jejunal bypass" ;
rdfs:comment "This is any condition in which the main influencing factor is a duodenal-jejunal bypass, a surgical procedure which involves transection of the duodenum proximally and transection of the jejunum distal to the ligament of Treitz. The distal end of the jejunum is anastomosed to the proximal end of the duodenum (duodenojejunal anastomosis), which creates the bypass of the duodenum and most of the jejunum. The biliopancreatic limb is anastomosed to the alimentary limb distal to the duodenojejunal anastomosis in a Roux-en-Y fashion to divert biliopancreatic juice to the ileum." ;
rdfs:subClassOf obo:XCO_0001436 .
obo:XCO_0001073 a rdfs:Class ;
rdfs:label "gene transfer of the KL gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the klotho gene (KL) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000765 a rdfs:Class ;
rdfs:label "rat anti-26 kDa T cells" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni ." ;
rdfs:subClassOf obo:XCO_0000763 .
obo:XCO_0000206 a rdfs:Class ;
rdfs:label "N-nitrosodiethylamine" ;
rdfs:comment "A component of tobacco smoke which has been shown to be mutagenic and carcinogenic in animal studies." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000205 .
obo:XCO_0001078 a rdfs:Class ;
rdfs:label "controlled bisphenol F content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is bisphenol F in a drink made up of water and a specified amount of bisphenol F consumed by an organism as part of an experiment. Bisphenol F is an organic compound with the chemical formula (HOC6H4)2CH2." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001165 a rdfs:Class ;
rdfs:label "lapatinib" ;
rdfs:comment "This is any condition whose main influencing factor is lapatinib, a quinazoline derivative that inhibits epidermal growth factor receptor (Egfr) and erb-b2 receptor tyrosine kinase 2 (Erbb2/Her2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress Erbb2/Her2." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000970 .
obo:XCO_0001463 a rdfs:Class ;
rdfs:label "hyperbaric chamber" ;
rdfs:comment "This is any condition in which the main influencing factor is a hyperbaric chamber, which raises atmospheric pressure to simulate atmospheric conditions below sea level or underwater. A hyperbaric chamber may use ambient air at high pressure (hyperbaric air) or air with high oxygen content at high pressure (hyperbaric oxygen therapy)." ;
rdfs:subClassOf obo:XCO_0001405 .
obo:XCO_0001317 a rdfs:Class ;
rdfs:label "C4 spinal cord hemi-contusion" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental surgical procedure involving hemilaminectomy/laminectomy of the fourth cervical vertebra and delivery of a controlled contusion to one side of the spinal cord by a mechanical apparatus." ;
rdfs:subClassOf obo:XCO_0001041 .
obo:XCO_0000781 a rdfs:Class ;
rdfs:label "positively charged liposomes" ;
rdfs:comment "An experimental condition in which the main influencing factor is positively charged liposomes, artificial positively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances." ;
rdfs:subClassOf obo:XCO_0000780 .
obo:XCO_0000362 a rdfs:Class ;
rdfs:label "physical restraint in plastic bag" ;
rdfs:comment "The use of a pouch made from a very thin flexible plastic (any of various organic compounds produced by polymerization, capable of being molded, extruded, cast into various shapes and films) to limit some or all of an animal's normal movements." ;
rdfs:subClassOf obo:XCO_0000158 .
obo:XCO_0001507 a rdfs:Class ;
rdfs:label "cobalt pellet implantation in muscle" ;
rdfs:comment "This is any condition in which the main influencing factor is the surgical implantation of cobalt pellet(s) in muscle. Cobalt is a hard, brittle transition metal used in metal alloys, batteries, and in colorants." ;
rdfs:subClassOf obo:XCO_0001504 .
obo:XCO_0001552 a rdfs:Class ;
rdfs:label "liquid diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a liquid diet, a diet consisting of only liquids to provide essential nutrients and hydration. A liquid diet may include any food type able to be delivered easily through a drinking straw." ;
rdfs:subClassOf obo:XCO_0000020 .
obo:XCO_0001711 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to guanine deaminase MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to an autoantibody-generating level of guanine deaminase (GDA) multiple antigenic peptides (MAPs) that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) GDA exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001722 .
obo:XCO_0000941 a rdfs:Class ;
rdfs:label "controlled ex vivo pancreas perfusion" ;
rdfs:comment "This is an experimental condition consisting of perfusion of the isolated pancreas with some physiological buffer (consisting of controlled solute composition and specific flow rate) in through the celiac artery and out through a portal vein." ;
rdfs:subClassOf obo:XCO_0000940 .
obo:XCO_0001215 a rdfs:Class ;
rdfs:label "controlled fructose content reverse osmosis-filtered drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of reverse osmosis-filtered water and a specified amount of fructose consumed by an organism as part of an experiment. Fructose is one of three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion." ;
rdfs:subClassOf obo:XCO_0000429 .
obo:XCO_0001157 a rdfs:Class ;
rdfs:label "esomeprazole" ;
rdfs:comment "This is any condition in which the main influencing factor is esomeprazole, an inhibitor of gastric acid secretion used for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001038 a rdfs:Class ;
rdfs:label "PBS-filled liposomes" ;
rdfs:comment "This is any condition in which the main influencing factor is PBS-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing phosphate buffered saline." ;
rdfs:subClassOf obo:XCO_0000780 .
obo:XCO_0000477 a rdfs:Class ;
rdfs:label "Streptococcus pneumoniae D39" ;
rdfs:comment "This is any condition in which the main influencing factor is Streptococcus pneumoniae D39, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers." ;
rdfs:subClassOf obo:XCO_0000476 .
obo:XCO_0000709 a rdfs:Class ;
rdfs:label "cancer cells" ;
rdfs:comment "A condition in which cells from one organism are used to cause cancer in another organism by injection of, or other means of transferring, live cells from the donor organism to the host organism. Cancer is a disease characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." ;
rdfs:subClassOf obo:XCO_0000258 .
obo:XCO_0000995 a rdfs:Class ;
rdfs:label "PDGF-AA" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is a dimeric isoform of platelet-derived growth factor (PDGF-AA). All PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. PDGF appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation." .
obo:XCO_0000351 a rdfs:Class ;
rdfs:label "4-nitroquinoline N-oxide" ;
rdfs:comment "A condition in which the major influencing factor is 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000205 .
obo:XCO_0001306 a rdfs:Class ;
rdfs:label "experimental traumatic muscle injury" ;
rdfs:comment "This is a condition induced by an mechanical procedure involving controlled trauma to skeletal muscle. The controlled muscle trauma may be to model contusion, strain, or laceration." ;
rdfs:subClassOf obo:XCO_0001100 .
obo:XCO_0001583 a rdfs:Class ;
rdfs:label "controlled chlorogenic acid content, CSAA diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a choline‐sufficient, amino acid‐defined (CSAA) diet with controlled chlorogenic acid content." ;
rdfs:subClassOf obo:XCO_0001578 .
obo:XCO_0000470 a rdfs:Class ;
rdfs:label "flavonoid" ;
rdfs:comment "Condition in which the main influencing factor is a flavonoid, any of a class of plant secondary metabolites that have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a heterocyclic ring (C)." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000798 a rdfs:Class ;
rdfs:label "nociceptin" ;
rdfs:comment "Generated from the gene PNOC, which produces a preproprotein, which in subsequently processed to form multiple protein products. Nociceptin a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity." ;
rdfs:subClassOf obo:XCO_0000228 .
obo:XCO_0000601 a rdfs:Class ;
rdfs:label "gene transfer of the rat natriuretic peptide B gene using an adenovirus vector" ;
rdfs:comment "A condition in which the rat natriuretic peptide B gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000760 a rdfs:Class ;
rdfs:label "26 kDa Schistosoma mansoni antigen" ;
rdfs:comment "A condition in which the major influencing factor is a soluble Schistosoma mansoni protein expressed by the schistosomulum and target of cytotoxic IgE antibodies." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000647 a rdfs:Class ;
rdfs:label "darusentan" ;
rdfs:comment "A selective endothelin ETA receptor antagonist. It is being evaluated as a treatment for congestive heart failure and hypertension." ;
rdfs:subClassOf obo:XCO_0000730 .
obo:XCO_0000776 a rdfs:Class ;
rdfs:label "fatty acid" ;
rdfs:comment "This is any condition in which the main influencing factor is an aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000807 a rdfs:Class ;
rdfs:label "tetrahydrocurcumin" ;
rdfs:comment "A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. It is is a major herbal antioxidant and anti-inflammatory agent" ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000505 .
obo:XCO_0000501 a rdfs:Class ;
rdfs:label "rotenone" ;
rdfs:comment "A condition in which the main influencing factor is rotenone, an insecticide and piscicide extracted from Leguminosa plants. Rotenone can be used to induce degeneration of dopaminergic neurons in animal models." ;
rdfs:subClassOf obo:XCO_0000496 , obo:XCO_0000497 .
obo:XCO_0001146 a rdfs:Class ;
rdfs:label "clarithromycin" ;
rdfs:comment "This is any condition in which the main influencing factor is clarithromycin, a synthetic macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. Clarithromycin is derived from erythromycin and is a protein synthesis inhibitor in bacteria." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000532 .
obo:XCO_0000399 a rdfs:Class ;
rdfs:label "complex ion" ;
rdfs:comment "A metal ion surrounded by, and forming coordinate covalent bonds with, a set of ligands comprised of any combination of other molecules or ions able to donate an electron pair." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0000703 a rdfs:Class ;
rdfs:label "2,4,5 trimethylthiazoline" ;
rdfs:comment "A constituent of fox urine and feces that may be an innately aversive odor to rodents." ;
rdfs:subClassOf obo:XCO_0000702 .
obo:XCO_0000684 a rdfs:Class ;
rdfs:label "nateglinide" ;
rdfs:comment "A condition in which the main influencing factor is nateglinide, an N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus." ;
rdfs:subClassOf obo:XCO_0000407 .
obo:XCO_0000456 a rdfs:Class ;
rdfs:label "retinyl palmitate" ;
rdfs:comment "Any condition in which the primary influencing agent is retinyl palmitate, the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2." ;
rdfs:subClassOf obo:XCO_0000271 .
obo:XCO_0000051 a rdfs:Class ;
rdfs:label "taste stimulus" ;
rdfs:comment "Any action or condition designed to cause the registration or perception of a stimulus by the gustatory receptors in the tongue. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." ;
rdfs:subClassOf obo:XCO_0000047 .
obo:XCO_0000250 a rdfs:Class ;
rdfs:label "right kidney transplant" ;
rdfs:comment "A surgical procedure in which the right kidney from a donor organism is implanted into a recipient organism." ;
rdfs:subClassOf obo:XCO_0000248 .
obo:XCO_0000219 a rdfs:Class ;
rdfs:label "dihydrocapsaicin" ;
rdfs:comment "A capsaicinoid which is an irritant and a selective TRPV1 (transient receptor potential cation channel, subfamily V, member 1) agonist." ;
rdfs:subClassOf obo:XCO_0000217 .
obo:XCO_0000697 a rdfs:Class ;
rdfs:label "GSK2181236A" ;
rdfs:comment "This is any condition in which the main influencing factor is GSK2181236A, a small molecule actvator of soluble guanylate cyclase." ;
rdfs:subClassOf obo:XCO_0000695 .
obo:XCO_0001700 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to collapsin response mediator protein 1 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to an autoantibody-generating level of collapsin response mediator protein 1 (CRMP1) multiple antigenic peptides (MAPs). This is a condition typically studied to determine the effect of maternal (F0) CRMP1 exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001698 .
obo:XCO_0000488 a rdfs:Class ;
rdfs:label "social environment condition" ;
rdfs:comment "Any condition related to or affecting the external interactions and relationships of a single organism, between single organisms, or within or between groups of organisms." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001674 a rdfs:Class ;
rdfs:label "peripheral nerve cone-shaped conduit implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is a peripheral nerve stump cone-shaped conduit implantation, which aids the regeneration of a nerve from a proximal stump caused by transection, ablation, or other damage. The conduit is created in the shape of a frustum of a cone, with the proximal diameter greater than the distal diameter. Ideally, the spatially-constrained, cone-shaped conduit guides the regenerating nerve from the proximal to distal stump more efficently than a cylindrical conduit." ;
rdfs:subClassOf obo:XCO_0001673 .
obo:XCO_0000903 a rdfs:Class ;
rdfs:label "99mTc-mebrofenin" ;
rdfs:comment "Technetium (99mTc) mebrofenin is a diagnostic radiopharmaceutical used for imaging of the liver and the gallbladder." ;
rdfs:subClassOf obo:XCO_0000171 .
obo:XCO_0000850 a rdfs:Class ;
rdfs:label "therapeutic agent" ;
rdfs:comment "This is any condition in which the main influencing factor is a chemical, biologic, organism, or action that exerts some force or effect resulting in a favorable outcome or improvement in the symptoms of a disorder or disease." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000410 a rdfs:Class ;
rdfs:label "controlled metformin content diet" ;
rdfs:comment "A solid diet in which the amount of metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis), is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000743 a rdfs:Class ;
rdfs:label "Haemophilus" ;
rdfs:comment "A condition in which the primary influencing factor is a species of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." ;
rdfs:subClassOf obo:XCO_0000475 .
obo:XCO_0001204 a rdfs:Class ;
rdfs:label "pentoxifylline" ;
rdfs:comment "This is any condition in which the main influencing factor is pentoxifylline, a synthetic dimethylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. Pentoxifylline has both anti-oxidant and anti-inflammatory properties." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000505 , obo:XCO_0000523 .
obo:XCO_0000686 a rdfs:Class ;
rdfs:label "Intralipid 20" ;
rdfs:comment "A sterile, non‑pyrogenic fat emulsion intended as a source of calories and essential fatty acids for use in a pharmacy admixture program. It is made up of 20% Soybean Oil, 1.2% Egg Yolk, Phospholipids, 2.25% Glycerin, and Water for Injection. In addition, sodium hydroxide has been added to adjust the pH so that the final product pH is 6 to 8.9." ;
rdfs:subClassOf obo:XCO_0000685 .
obo:XCO_0000287 a rdfs:Class ;
rdfs:label "interphotoreceptor retinoid-binding protein" ;
rdfs:comment "A condition in which the major influencing factor is a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000583 a rdfs:Class ;
rdfs:label "obsolete controlled omeprazole content oral gavage" ;
rdfs:comment "OBSOLETE. An oral gavage solution made up of solvent and a specified amount of omeprazole." .
obo:XCO_0000843 a rdfs:Class ;
rdfs:label "mecamylamine" ;
rdfs:comment "Any condition in which the main influencing factor is mecamylamine, a ganglionic blocking agent that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system." ;
rdfs:subClassOf obo:XCO_0000842 .
obo:XCO_0001572 a rdfs:Class ;
rdfs:label "2,2',5,5'-tetrachlorobiphenyl" ;
rdfs:comment "This is any condition in which the main influencing factor is 2,2',5,5'-tetrachlorobiphenyl, a tetrachlorobiphenyl that is biphenyl in which the hydrogens at the 2 and 5 position of each benzene ring are replaced by chlorines." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001540 a rdfs:Class ;
rdfs:label "skeletal muscle ablation" ;
rdfs:comment "This is any condition in which the main influencing factor is skeletal muscle ablation, which is surgical removal of all or part of one or more skeletal muscles. It is an experimental procedure used in laboratory animals to observe and determine what compensation measures are brought to bear in the remaining musculature." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000450 a rdfs:Class ;
rdfs:label "proestrus" ;
rdfs:comment "A preparatory period immediately preceding estrus and characterized by growth of graafian follicles, increased estrogenic activity, and alteration of uterine and vaginal mucosa." .
obo:XCO_0000977 a rdfs:Class ;
rdfs:label "supplemented Williams' E Medium" ;
rdfs:comment "This is any experimental condition in which cells derived from a multicellular organism are cultured in medium enriched in amino acids, glucose, and other unique ingredients and supplemented with dexamethasone, penicillin/streptomycin, ITS+, GlutaMAX and HEPES; Gibco #CM4000. William's E Medium was originally developed by Williams and Gunn as reduced serum-supplemented medium for long-term cell cultures of adult rat liver epithelial cells." ;
rdfs:subClassOf obo:XCO_0000965 .
obo:XCO_0001557 a rdfs:Class ;
rdfs:label "ventral trunk of subdiaphragmatic vagus nerve direct electrical stimulation" ;
rdfs:comment "This is any condition in which the main influencing factor is direct electrical stimulation of the ventral trunk of the subdiaphragmatic vagus nerve. The electrical stimulation is delivered by some sort of bioelectronic implant. The vagus nerve (the tenth cranial nerve), is a mixed nerve that carries both sensory and motor information. The vagus nerve is the longest nerve in the human body as it originates in the brainstem and travels down the neck and into the thorax and abdomen." ;
rdfs:subClassOf obo:XCO_0000521 .
obo:XCO_0000244 a rdfs:Class ;
rdfs:label "controlled fructose content diet" ;
rdfs:comment "A solid diet in which the amount of fructose, the monosaccharide found in honey and many sweet fruits which chemically combines with glucose to form the disaccharide sucrose, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000448 a rdfs:Class ;
rdfs:label "metestrus" ;
rdfs:comment "The period of regression and sexual inactivity in females of non-primate mammalian species between estrus and diestrus." .
obo:XCO_0000984 a rdfs:Class ;
rdfs:label "gene transfer of the rat wild type Ccny gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the rat wild type cyclin Y gene (Ccny) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of rat cyclin Y in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0001395 a rdfs:Class ;
rdfs:label "diaphyseal resection" ;
rdfs:comment "This is any condition in which the main influencing factor is a diaphyseal resection, which is the surgical removal of a length of bone from the diaphysis, the section of a long bone between the two epiphyses." ;
rdfs:subClassOf obo:XCO_0000026 , obo:XCO_0001394 .
obo:XCO_0001530 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to hyperglycemia" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to hyperglycemia (blood glucose level > 180 mg/dl) that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) hyperglycemia exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." .
obo:XCO_0001482 a rdfs:Class ;
rdfs:label "controlled, oxygenated ex vivo liver perfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is perfusion (recirculated or single pass) of isolated liver with some oxygenated, physiological buffer (consisting of controlled solute composition and specific flow rate) through the hepatic portal vein." ;
rdfs:subClassOf obo:XCO_0001479 .
obo:XCO_0000422 a rdfs:Class ;
rdfs:label "quinone" ;
rdfs:comment "Any condition in which the main influencing factor is a quinone, a member of a class of compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000298 a rdfs:Class ;
rdfs:label "controlled saccharin content drinking water" ;
rdfs:comment "Water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O) supplied as a drink, that is, as a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., in which the amount of saccharin, a cyclic imine of 2-sulfobenzoic acid which is 500 times sweeter than sugar and used as a nonnutritive sweetener, is adjusted to a requirement." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001471 a rdfs:Class ;
rdfs:label "ultrasound" ;
rdfs:comment "This is any condition in which the main influencing factor is ultrasound, a technique used in both medical diagnostics and therapeutics. As a therapeutic method, it allows non-invasive means to treat tumors, thrombi, various neurodegenerative diseases, and other medical issues." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001518 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to a controlled protein content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is maternal exposure to a controlled protein content diet that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) controlled protein content diet on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000030 .
obo:XCO_0000455 a rdfs:Class ;
rdfs:label "controlled corn oil content diet" ;
rdfs:comment "A solid diet in which the amount of corn oil is maintained at a specified level. Corn oil is a refined fixed, that is, nonvolatile, oil obtained from corn, the embryo of Zea mays plant. It is sometimes promoted as a good source of polyunsaturated fatty acids." ;
rdfs:subClassOf obo:XCO_0000454 .
obo:XCO_0001288 a rdfs:Class ;
rdfs:label "acetone drop stimulus" ;
rdfs:comment "This is any condition in which the main influencing factor is an acetone drop stimulus, usually encountered in a test used to measure cold allodynia behavior in the experimental subject, typically a rodent. The test involves applying a small drop (50 - 100 ul) of acetone to the mid-plantar area of the hind paw and recording the resulting behavior for one minute. The skin temperature of the subject drops ~3 - 5 degrees during the test." ;
rdfs:subClassOf obo:XCO_0000052 .
obo:XCO_0001541 a rdfs:Class ;
rdfs:label "unilateral ablation of the gastrocnemius and soleus muscles" ;
rdfs:comment "This is any condition in which the main influencing factor is unilateral, surgical removal of the gastrocnemius (distal two-thirds) and soleus muscles. This synergist ablation is performed in experimental animals to cause functional overload in the plantaris muscle." ;
rdfs:subClassOf obo:XCO_0001540 .
obo:XCO_0000464 a rdfs:Class ;
rdfs:label "controlled ex vivo organ condition" ;
rdfs:comment "Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000201 a rdfs:Class ;
rdfs:label "orchiectomy" ;
rdfs:comment "Surgical removal of one or both testes." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0001179 a rdfs:Class ;
rdfs:label "iopromide" ;
rdfs:comment "This is any condition in which the main influencing factor is iopromide, an organoiodine compound and a dicarboxylic acid diamide used as an x-ray contrast agent for angiography. Iopromide is also a nephrotoxic agent." ;
rdfs:subClassOf obo:XCO_0001112 .
obo:XCO_0000579 a rdfs:Class ;
rdfs:label "controlled in situ gastrointestinal condition" ;
rdfs:comment "Any experimental condition in which the internal or external environment of the gastrointestinal system is altered." ;
rdfs:subClassOf obo:XCO_0000166 .
obo:XCO_0000829 a rdfs:Class ;
rdfs:label "corn oil" ;
rdfs:comment "Corn oil is a refined fixed, that is, nonvolatile, oil obtained from from the germ of corn kernels. It has high polyunsaturated lipid content and is used as a delivery vehicle for lipophilic substances." ;
rdfs:subClassOf obo:XCO_0000774 .
obo:XCO_0000442 a rdfs:Class ;
rdfs:label "controlled 2-acetamidofluorene content diet" ;
rdfs:comment "A solid diet in which the amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000179 a rdfs:Class ;
rdfs:label "ionizing ultraviolet radiation exposure" ;
rdfs:comment "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 10 and 120 nm. Radiation (i.e. ultraviolet light) at this wavelength is considered ionizing, that is, composed of photons that individually carry enough energy to liberate an electron from an atom or molecule without raising the bulk material to ionization temperature." ;
rdfs:subClassOf obo:XCO_0000039 , obo:XCO_0000042 .
obo:XCO_0001502 a rdfs:Class ;
rdfs:label "controlled phosphate content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled phosphate content diet, which is a regimen of solid food in which the amount of phosphate consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001131 a rdfs:Class ;
rdfs:label "azithromycin" ;
rdfs:comment "This is any condition in which the main influencing factor is azithromycin, a semi-synthetic, broad-spectrum, macrolide antibiotic structurally related to erythromycin. It has been used in the treatment of various types of bacterial infections." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0000060 a rdfs:Class ;
rdfs:label "mental activity" ;
rdfs:comment "Being in a state of action within the mind often involving manipulation of words or numbers." ;
rdfs:subClassOf obo:XCO_0000001 .
obo:XCO_0000631 a rdfs:Class ;
rdfs:label "atropine" ;
rdfs:comment "A naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters." ;
rdfs:subClassOf obo:XCO_0000630 .
obo:XCO_0000005 a rdfs:Class ;
rdfs:label "running on treadmill" ;
rdfs:comment "The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place." ;
rdfs:subClassOf obo:XCO_0000008 .
obo:XCO_0000093 a rdfs:Class ;
rdfs:label "polycyclic arene" ;
rdfs:comment "Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by alternating double and single bonds that may be represented graphically by multiple interlinking circular or triangular forms." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000278 .
obo:XCO_0001295 a rdfs:Class ;
rdfs:label "gingerol" ;
rdfs:comment "This is any condition in which the main influencing factor is gingerol, a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1. Gingerol is a constituent of fresh ginger and other plants. Gingerol may have antifungal and antineoplastic properties." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0001489 .
obo:XCO_0000663 a rdfs:Class ;
rdfs:label "two-kidney, two-clip occlusion" ;
rdfs:comment "A surgical manipulation causing blood vessel blockage by the dissection and clipping of both renal arteries." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0000506 a rdfs:Class ;
rdfs:label "non-steroidal anti-inflammatory drug" ;
rdfs:comment "This is any condition in which the main influencing factor is a non-steroidal anti-inflammatory drug. NSAIDs act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000505 , obo:XCO_0000523 .
obo:XCO_0001335 a rdfs:Class ;
rdfs:label "transgenerational maternal exposure to oxycodone" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to oxycodone that has transgenerational effects. This is a condition typically studied to determine the effect of maternal (F0) oxycodone use/exposure on the F2/F3 offspring by direct effects on the F1/F2 generations in utero or during nursing, or by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of F1 offspring to affect the F2 generation. The maternal exposure may be any time after gestational development of germline cells in the F1 generation up to the time of weaning of F1 offspring to affect the F3 generation." ;
rdfs:subClassOf obo:XCO_0001330 .
obo:XCO_0001349 a rdfs:Class ;
rdfs:label "controlled enalapril content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled enalapril content diet, a regimen of solid food in which the amount of enalapril consumed is controlled. Enalapril is a prodrug that is rapidly metabolized in the liver to enalaprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000717 a rdfs:Class ;
rdfs:label "MRI contrast agent" ;
rdfs:comment "MRI contrast agents are an indispensable part of magnetic resonance imaging. Contrast agents are used to improve the visibility of internal body structures in magnetic resonance imaging (MRI)." ;
rdfs:subClassOf obo:XCO_0001451 .
obo:XCO_0001609 a rdfs:Class ;
rdfs:label "gestational maternal exposure to standard rat chow diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to standard rat chow. This is a condition typically studied to determine the effect of maternal (F0) standard rat chow diet on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001608 .
obo:XCO_0000695 a rdfs:Class ;
rdfs:label "soluble guanylate cyclase activator" ;
rdfs:comment "An effector that binds to and activates soluble guanylate cyclase (EC 4.6.1.2). It increases the activity of the enzyme only when the heme iron is oxidized (Fe3+) or the heme group is missing." ;
rdfs:subClassOf obo:XCO_0000694 .
obo:XCO_0001851 a rdfs:Class ;
rdfs:label "controlled ethanol content liquid diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a liquid diet in which the amount of ethanol is maintained at a specified level. Ethanol is the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages." ;
rdfs:subClassOf obo:XCO_0001552 .
obo:XCO_0000078 a rdfs:Class ;
rdfs:label "cigar smoking" ;
rdfs:comment "The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigar, a rolled cylinder of tobacco wrapped in tobacco leaves." ;
rdfs:subClassOf obo:XCO_0000077 .
obo:XCO_0001153 a rdfs:Class ;
rdfs:label "diphenhydramine" ;
rdfs:comment "This is any condition whose main influencing factor is diphenhydramine, an histamine H1 antagonist used for for hypersensitivity reactions, for pruritus, as a hypnotic, and as an ingredient in common cold preparations." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001180 a rdfs:Class ;
rdfs:label "OC43p" ;
rdfs:comment "This is any condition in which the major influencing factor is OC43p, a synthetic peptide whose sequence (VSKIVHFFKTFTTSTALAFA) is derived from the Human coronavirus OC43 gene ORF1ab/ORF1ab polyprotein. This sequence is homologous to the myelin basic protein pronociceptive peptide MBP84-104 from human/rat." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000117 a rdfs:Class ;
rdfs:label "saline solution perfusate" ;
rdfs:comment "A fluid containing a specified amount of a chemical salt, for example sodium chloride, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." ;
rdfs:subClassOf obo:XCO_0000115 .
obo:XCO_0001460 a rdfs:Class ;
rdfs:label "glycerol" ;
rdfs:comment "This is any condition in which the main influencing factor is glycerol, a trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. Glycerol is used as a solvent, emollient, pharmaceutical agent, and sweetening agent." ;
rdfs:subClassOf obo:XCO_0000323 , obo:XCO_0001231 .
obo:XCO_0001675 a rdfs:Class ;
rdfs:label "peripheral nerve cylinder-shaped conduit implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is a peripheral nerve stump cylinder-shaped conduit implantation, which aids the regeneration of a nerve from a proximal stump caused by transection, ablation, or other damage. Ideally, the conduit guides the regenerating nerve from the proximal to distal stump, therefore replacing the portion of the nerve that has been damaged or removed." ;
rdfs:subClassOf obo:XCO_0001673 .
obo:XCO_0001373 a rdfs:Class ;
rdfs:label "surgical nerve transection" ;
rdfs:comment "This is any condition in which the main influencing factor is transection of some specific nerve, usually performed on a laboratory animal to study peripheral nerve injury." ;
rdfs:subClassOf obo:XCO_0000373 .
obo:XCO_0000038 a rdfs:Class ;
rdfs:label "radiation exposure" ;
rdfs:comment "The condition of being subjected to any type of energy transmitted by waves through space or through some medium or to a stream of particles, such as electrons or alpha particles." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000980 a rdfs:Class ;
rdfs:label "controlled content gelled diet" ;
rdfs:comment "This is an experimental regimen of gelled food in which the amount of solid elements, water, and some other component(s) in the diet are controlled." ;
rdfs:subClassOf obo:XCO_0000916 .
obo:XCO_0000540 a rdfs:Class ;
rdfs:label "delapril" ;
rdfs:comment "An experimental condition in which the main influencing factor is delapril, an antihypertensive prodrug that, when converted to its active metabolites 5-hydroxy delapril diacid and delapril diacid, acts as an angiotensin-converting enzyme (ACE) inhibitor." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0000330 a rdfs:Class ;
rdfs:label "deoxycorticosterone" ;
rdfs:comment "Any condition in which the main influencing factor is deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone, or a derivative of that hormone." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0001562 a rdfs:Class ;
rdfs:label "protamine sulfate" ;
rdfs:comment "This is any condition in which the main influencing factor is protamine sulfate, an anti-heparin drug used to reverse the anti-coagulant effects of heparin. Protamine sulfate effects the reversal heparin activity predominantly via the formation of an inactive complex between the anionic heparin and its own cationic state." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0001474 a rdfs:Class ;
rdfs:label "cerebral artery perforation sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a cerebral artery perforation sham procedure, which follows the same surgical process as a cerebral artery perforation procedure, but no perforation is generated. The sham procedure includes surgical exposure of the carotid artery and passage of a blunt, nylon monofilament through the internal carotid artery to the junction of the anterior and middle cerebral arteries." ;
rdfs:subClassOf obo:XCO_0001473 .
obo:XCO_0001327 a rdfs:Class ;
rdfs:label "letrozole" ;
rdfs:comment "This is any condition in which the main influencing factor is letrozole, a triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to anastrozole. Letrozole is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0000642 a rdfs:Class ;
rdfs:label "monocrotaline" ;
rdfs:comment "Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment." ;
rdfs:subClassOf obo:XCO_0000239 .
obo:XCO_0001380 a rdfs:Class ;
rdfs:label "metyrapone" ;
rdfs:comment "This is any condition in which the main influencing factor is metyrapone, an aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. It is a steroid 11beta-monooxygenase (Cyp11b1) inhibitor used in a test of the feedback hypothalamic-pituitary mechanism for the diagnosis of adrenal insufficiency." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001049 a rdfs:Class ;
rdfs:label "nicotine" ;
rdfs:comment "This is any condition in which the main influencing factor is nicotine, a highly toxic alkaloid. Nicotine is a racemate composed of equimolar amounts of (R)- and (S)-nicotine. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission." ;
rdfs:subClassOf obo:XCO_0000496 , obo:XCO_0000693 .
obo:XCO_0001790 a rdfs:Class ;
rdfs:label "gene transfer of the human GALT gene using an adeno-associated virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of the human GALT (galactose-1-phosphate uridylyltransferase) gene using an adeno-associated virus vector. Gene transfer into a cell or organism using an adeno-associated virus vector is performed to induce synthesis of the carried gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0001575 .
obo:XCO_0000612 a rdfs:Class ;
rdfs:label "endothelin-1" ;
rdfs:comment "This is any condition in which the main influencing factor is endothelin-1, a 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production." ;
rdfs:subClassOf obo:XCO_0000783 .
obo:XCO_0000618 a rdfs:Class ;
rdfs:label "sodium channel inhibitor" ;
rdfs:comment "A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity." ;
rdfs:subClassOf obo:XCO_0000222 .
obo:XCO_0000433 a rdfs:Class ;
rdfs:label "controlled sucrose content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of sucrose consumed by an organism as part of an experiment. Sucrose is a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001621 a rdfs:Class ;
rdfs:label "Corydalis yanhusuo" ;
rdfs:comment "This is any condition in which the main influencing factor is Corydalis yanhusuo, a plant species in the genus Corydalis. The tuber of Corydalis yanhusuo, frequently mislabeled as the root, is an important therapeutic agent for pain relief in traditional Chinese medicine (TCM)." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000731 a rdfs:Class ;
rdfs:label "controlled enrasentan content diet" ;
rdfs:comment "A regimen of solid food in which the amount of enrasentan consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000729 .
obo:XCO_0000082 a rdfs:Class ;
rdfs:label "sitting position" ;
rdfs:comment "A position of rest in which the weight is largely supported by the buttocks, usually with the body vertical." ;
rdfs:subClassOf obo:XCO_0000081 .
obo:XCO_0000832 a rdfs:Class ;
rdfs:label "lensotomy" ;
rdfs:comment "Any process involving manual and instrumental techniques for incision of a lens in the eye of an organism to investigate and/or treat a pathological condition." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001089 a rdfs:Class ;
rdfs:label "hirudin" ;
rdfs:comment "This is any condition in which the main influencing factor is a hirudin, a single-chain polypeptide of about 65 amino acids (7 kDa) found in leech saliva, that has a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Hirudins, both natural and synthetic, are inhibitors of thrombin." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0001090 .
obo:XCO_0000258 a rdfs:Class ;
rdfs:label "disease-inducing agent" ;
rdfs:comment "Any phenomenon, chemical or biologic substance, or organism that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000067 a rdfs:Class ;
rdfs:label "body position change, seated to standing" ;
rdfs:subClassOf obo:XCO_0000066 .
obo:XCO_0001391 a rdfs:Class ;
rdfs:label "CGG-Cit hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a CGG-Cit hydrogel, a citrate (Cit)-coordinated CGG hydrogel composed of gelatin and chitosan networks covalently cross-linked by genipin and coordinated with sodium citrate (Na3Cit). Sodium citrate used in the formation of these gel scaffolds increase mechanical performance and the migration, proliferation, and osteodifferentiation of endogenous mesenchymal stem cells (MSCs)." ;
rdfs:subClassOf obo:XCO_0001390 .
obo:XCO_0000624 a rdfs:Class ;
rdfs:label "thiobutabarbital" ;
rdfs:comment "A short-acting barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is still used in veterinary medicine for induction in surgical anaesthesia." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000950 .
obo:XCO_0000545 a rdfs:Class ;
rdfs:label "vitamin D3" ;
rdfs:comment "An experimental condition in which the main influencing factor is vitamin D3, a form of vitamin D which is naturally synthesized in the skin of animals by the action of ultraviolet B (UVB) radiation on 7-dehydrocholesterol. Vitamin D3 is also found in some foods and can be used as a dietary supplement. The D3 vitamer has been found to be more efficiently absorbed in the human intestine and/or more biologically active than the D2 vitamer." ;
rdfs:subClassOf obo:XCO_0000543 .
obo:XCO_0000636 a rdfs:Class ;
rdfs:label "immunosuppressive agent" ;
rdfs:comment "This is any condition in which the main influencing factor is an agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0001663 a rdfs:Class ;
rdfs:label "Helicobacter pylori " ;
rdfs:comment "This is any condition in which the main influencing factor is Helicobacter pylori, a microaerophilic, gram-negative spiral bacteria active as a human gastric pathogen, although most individuals harboring the bacteria are asymptomatic. Helicobacter pylori was originally classified in the genus Campylobacter, but has been officially transferred to Helicobacter." ;
rdfs:subClassOf obo:XCO_0000475 .
obo:XCO_0000653 a rdfs:Class ;
rdfs:label "ionotropic glutamate receptor antagonist" ;
rdfs:comment "Any condition in which the main influencing factor is an agent that blocks the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000947 a rdfs:Class ;
rdfs:label "NMDA receptor antagonist" ;
rdfs:comment "This is a condition in which the main influencing factor is a drug or agent that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000160 .
obo:XCO_0000280 a rdfs:Class ;
rdfs:label "squalene" ;
rdfs:comment "A triterpene, that is a terpine containing six isoprene units, consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration. Squalene is the biochemical precursor to steroids." ;
rdfs:subClassOf obo:XCO_0000279 .
obo:XCO_0000071 a rdfs:Class ;
rdfs:label "beer" ;
rdfs:comment "An alcoholic drink brewed by fermenting malt with sugar and yeast and flavored with hops." ;
rdfs:subClassOf obo:XCO_0000070 .
obo:XCO_0001142 a rdfs:Class ;
rdfs:label "transfer of MIR143 mimic" ;
rdfs:comment "This is any condition in which the main influencing factor is a MIR143 mimic transferred into an organism or cell culture. MIR143 mimic is a chemically modified double-stranded RNA molecule designed to mimic endogenous MIR143 function. MIR143 is associated with cardiovascular and other diseases." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0001642 a rdfs:Class ;
rdfs:label "polymeric implant sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is an empty or vehicle-loaded polymeric implant, used as a study control for drugs or chemicals delivered by polymeric implant. Implants are cylindrical or other shaped devices, which are injected or implanted into the subcutaneous tissue with a large bore needle." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0001750 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to nicotine" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to nicotine that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) nicotine use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." .
obo:XCO_0000481 a rdfs:Class ;
rdfs:label "Haemophilus influenzae 86-028NP" ;
rdfs:comment "A condition in which the primary influencing factor is the 86-028NP strain of Haemophilus influenzae. 86-028NP is a pathogenic, nontypeable H. influenzae strain isolated from the nasopharynx of a child with chronic otitis media." ;
rdfs:subClassOf obo:XCO_0000480 .
obo:XCO_0001594 a rdfs:Class ;
rdfs:label "aluminium hydroxide" ;
rdfs:comment "This is any condition in which the main influencing factor is aluminium hydroxide, an antacid used for the symptomatic relief of heartburn. Aluminium hydroxide is also used in other applications: as an antiperspirant, as an emulsifier, in dentifrices, as an adjuvant in bacterins and vaccines, in water purification, etc." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000578 a rdfs:Class ;
rdfs:label "omeprazole" ;
rdfs:comment "This is any condition in which the main influencing factor is omeprazole, a highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome." ;
rdfs:subClassOf obo:XCO_0000577 .
obo:XCO_0001226 a rdfs:Class ;
rdfs:label "tacrine" ;
rdfs:comment "This is any condition in which the main influencing factor is tacrine, a centerally active cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine is also a histamine N-methyltransferase inhibitor." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001258 a rdfs:Class ;
rdfs:label "valproate" ;
rdfs:comment "This is any condition in which the main influencing factor is valproate, a branched-chain saturated fatty acid anion that is the conjugate base of valproic acid. Valproic acid is used in the treatment of epilepsy and bipolar disorder." ;
rdfs:subClassOf obo:XCO_0000950 .
obo:XCO_0000307 a rdfs:Class ;
rdfs:label "cold ambient air exposure" ;
rdfs:comment "An activity or condition in which the air surrounding or encircling the organism has a relatively low, or lower than considered normal, temperature, i.e., air in which the molecules possess a lower than normal amount of random kinetic energy." ;
rdfs:subClassOf obo:XCO_0000011 , obo:XCO_0000306 .
obo:XCO_0000991 a rdfs:Class ;
rdfs:label "GlutaMAX-I" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is GlutaMAX-I, a dipeptide (L-alanyl-L-glutamine) substitute for L-glutamine that can be used as a direct substitute for L-Glutamine at equimolar concentrations in mammalian and stem cell culture with minimal or no adaptation. L-alanyl-L-glutamine eliminates problems associated with the spontaneous breakdown of L-glutamine during incubation, is highly soluble in aqueous solution, and is heat stable." .
obo:XCO_0000680 a rdfs:Class ;
rdfs:label "antilipemic agent" ;
rdfs:comment "This is any condition in which the main influencing factor is a substance used to treat hyperlipidemia (an excess of lipids in the blood)." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0001447 a rdfs:Class ;
rdfs:label "T9 spinal cord contusion sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a T9 spinal cord contusion sham procedure, which follows the same surgical process as a T9 spinal cord contusion procedure, but no contusion is generated. The sham procedure includes laminectomy of the ninth thoracic vertebra and exposure of the spinal cord." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000412 a rdfs:Class ;
rdfs:label "gestation" ;
rdfs:comment "The state of a female and/or her offspring, and the processes which occur, during the period from conception to birth or termination of the pregnancy." ;
rdfs:subClassOf obo:XCO_0000411 .
obo:XCO_0001210 a rdfs:Class ;
rdfs:label "neomycin" ;
rdfs:comment "This is any condition in which the main influencing factor is neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is a minor component and a degradation product of B and C. Neomycin is a protein synthesis inhibitor and bacteriacidal agent, primarily effective against gram-negative bacteria." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0000276 a rdfs:Class ;
rdfs:label "hydrocarbon" ;
rdfs:comment "Any of a large group of organic compounds whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001300 a rdfs:Class ;
rdfs:label "cerebral reperfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is cerebral reperfusion, any situation in which the flow of blood to the cerebral hemispheres is restored after a period of blood vessel occlusion occurring experimentally." .
obo:XCO_0000894 a rdfs:Class ;
rdfs:label "controlled hesperidin content diet" ;
rdfs:comment "A regimen of solid food in which the amount of hesperidin, a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage, is controlled." ;
rdfs:subClassOf obo:XCO_0000726 , obo:XCO_0000896 .
obo:XCO_0001107 a rdfs:Class ;
rdfs:label "polymer" ;
rdfs:comment "This is any condition in which the main influencing factor is a polymer, any of a class of natural or synthetic substances composed of very large molecules, called macromolecules, which are multiples of simpler chemical units called monomers." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001362 a rdfs:Class ;
rdfs:label "experimental, post-traumatic osteoarthritis of the knee joint" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental post-traumatic osteoarthritis (PTOA) of the knee joint. This model of PTOA is initiated in rodents by axial compression overload of the joint to the point of ACL (anterior cruciate ligament) rupture." ;
rdfs:subClassOf obo:XCO_0001759 .
obo:XCO_0000467 a rdfs:Class ;
rdfs:label "retinoid" ;
rdfs:comment "Condition in which the main influencing factor is a retinoid, any of a group of compounds containing 20 carbon atoms and structurally related to retinal, retinol, and other substances, some of which exhibit vitamin A activity." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001815 a rdfs:Class ;
rdfs:label "anti-interleukin-17A antibody" ;
rdfs:comment "This is any condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with intterleukin-17A, a pro-inflammatory cytokine produced by activated T cells." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0001513 a rdfs:Class ;
rdfs:label "methylazoxymethanol acetate" ;
rdfs:comment "This is any condition in which the main influencing factor is methylazoxymethanol acetate, a neurotoxin which reduces DNA synthesis. Methylazoxymethanol acetate is used in making animal models of neurological diseases including schizophrenia and epilepsy. It may also be carcinogenic." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000496 .
obo:XCO_0000675 a rdfs:Class ;
rdfs:label "gene transfer using a retrovirus vector" ;
rdfs:comment "A condition in which gene transfer has been performed using a retrovirus as the carrier of the genetic material. A retrovirus is any of a family (Retroviridae) of single-stranded RNA viruses that produce reverse transcriptase by means of which DNA is produced using their RNA as a template and incorporated into the genome of infected cells." ;
rdfs:subClassOf obo:XCO_0000528 .
obo:XCO_0001653 a rdfs:Class ;
rdfs:label "SPF rat maintenance diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a specific-pathogen-free rat maintenance diet, an SPF diet with 180 g/kg crude protein and 3.40 kcal/g energy content." ;
rdfs:subClassOf obo:XCO_0001651 .
obo:XCO_0000747 a rdfs:Class ;
rdfs:label "housing with Pasteurellaceae-infected subject" ;
rdfs:comment "A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurellaceae infection during the time period leading up to the specified housing period. Pasteurellaceae is a large family of Gram-negative bacteria including the genera Pasteurella and Haemophilus, some of which are pathogenic." ;
rdfs:subClassOf obo:XCO_0000741 .
obo:XCO_0000431 a rdfs:Class ;
rdfs:label "disaccharide" ;
rdfs:comment "Any condition in which the main influencing factor is a disaccharide, a member of the class of sugars that yield two monosaccharide molecules upon hydrolysis." ;
rdfs:subClassOf obo:XCO_0000172 .
obo:XCO_0000437 a rdfs:Class ;
rdfs:label "controlled N-propyl-N-nitrosourea content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of N-propyl-N-nitrosourea (PNU) consumed by an organism as part of an experiment. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001344 a rdfs:Class ;
rdfs:label "Streptococcus pneumoniae 262" ;
rdfs:comment "This is any condition in which the main influencing factor is Streptococcus pneumoniae strain 262, a bacterium isolated from the sputum of a human male. This bacterial culture has applications in respiratory disease research. This strain is serotype 19 (Danish designation 19F)." ;
rdfs:subClassOf obo:XCO_0000476 .
obo:XCO_0000373 a rdfs:Class ;
rdfs:label "surgical denervation" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical denervation, which my involve transection, resection, or complete surgical removal of a nerve, any of the cordlike structures that convey impulses between the central nervous system and one or more parts of the body, and that each consist of an outer connective tissue sheath surrounding a bundle of conductive fibers." ;
rdfs:subClassOf obo:XCO_0001814 .
obo:XCO_0000567 a rdfs:Class ;
rdfs:label "adrenomedulin" ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000228 .
obo:XCO_0000691 a rdfs:Class ;
rdfs:label "controlled vitamin C content diet" ;
rdfs:comment "A solid diet in which the amount of vitamin C is maintained at a specified level. Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement." ;
rdfs:subClassOf obo:XCO_0000690 .
obo:XCO_0000340 a rdfs:Class ;
rdfs:label "solution" ;
rdfs:comment "Any condition in which the main influencing factor is a homogeneous mixture of molecules, atoms and/or ions dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000059 a rdfs:Class ;
rdfs:label "physical activity" ;
rdfs:comment "Action in which a part of the body or whole body is involved in movement." ;
rdfs:subClassOf obo:XCO_0000001 .
obo:XCO_0001120 a rdfs:Class ;
rdfs:label "almorexant" ;
rdfs:comment "This is any condition in which the main influencing factor is almorexant, an experimental drug developed to combat insomnia. Almorexant is a competitive, dual OX1 and OX2 receptor antagonist and selectively inhibits the functional consequences of OX1 and OX2 receptor activation, such as intracellular Ca2+ mobilization." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001168 a rdfs:Class ;
rdfs:label "polysorbate 80" ;
rdfs:comment "This is any condition in which the main influencing factor is polysorbate 80, a polymer composed of PEG-ylated sorbitan and oleic acid. Polysorbate 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics." ;
rdfs:subClassOf obo:XCO_0001167 .
obo:XCO_0000269 a rdfs:Class ;
rdfs:label "calcium channel inhibitor" ;
rdfs:comment "This is any condition in which the main influencing factor is any chemical substance which decreases or interferes with the activity of a calcium channel, one or more membrane-bound globular proteins that display selective permeability to calcium ions, the chemical element with atomic number 20 that has lost two electrons forming a cation with a charge of +2, and allow diffusion of these ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000222 .
obo:XCO_0000329 a rdfs:Class ;
rdfs:label "controlled deoxycorticosterone content saline drink" ;
rdfs:comment "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of sodium chloride (i.e. atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1) dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone." ;
rdfs:subClassOf obo:XCO_0000164 , obo:XCO_0000328 .
obo:XCO_0001272 a rdfs:Class ;
rdfs:label "zolpidem" ;
rdfs:comment "This is any condition in which the main influencing factor is zolpidem, an imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of insomnia." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0001804 a rdfs:Class ;
rdfs:label "human plasma-derived mitochondria" ;
rdfs:comment "This is any condition in which the main influencing factor is mitochondria derived from human plasma. Mitochondria are semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most eukaryotes. They are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0000318 a rdfs:Class ;
rdfs:label "surgical construction" ;
rdfs:comment "A process in which manual and instrumental techniques are used to assemble or combine parts or substances, especially in order to create something new." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001338 a rdfs:Class ;
rdfs:label "human adipose-derived stromal cells" ;
rdfs:comment "This is any condition in which the main influencing factor is human, adipose-derived stromal cells, which are isolated from lipoaspirates from healthy adult donors. They are mesenchymal stem cells that can be expanded in culture" ;
rdfs:subClassOf obo:XCO_0001393 .
obo:XCO_0001429 a rdfs:Class ;
rdfs:label "rat repair Schwann cells" ;
rdfs:comment "This is a condition in which the main influencing factor is rat repair Schwann cells, myelin cells that previously formed flattened sheaths around axons, then adopt an elongated bipolar morphology after nerve injury, allowing them to align to form a Schwann cell column named a Bungner band, which delineates the space in which the nerve regenerates." ;
rdfs:subClassOf obo:XCO_0001427 .
obo:XCO_0000958 a rdfs:Class ;
rdfs:label "artificial cerebrospinal fluid with 0.16 M sodium" ;
rdfs:comment "This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.16 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid." ;
rdfs:subClassOf obo:XCO_0000830 .
obo:XCO_0001261 a rdfs:Class ;
rdfs:label "Ma Xing Shi Gan decoction" ;
rdfs:comment "This is any condition in which the main influencing factor is Ma Xing Shi Gan decoction, an anti-inflammatory and antiviral drug of traditional Chinese medicine (TCM). Ma Xing Shi Gan decoction has shown some effectiveness in the treatment of COVID-19 infection." ;
rdfs:subClassOf obo:XCO_0000505 , obo:XCO_0000657 , obo:XCO_0001623 .
obo:XCO_0001733 a rdfs:Class ;
rdfs:label "experimental spinal cord transection at T8" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental transection of the rat spinal cord at the vertebral level of thoracic 8 (T8). This procedure involves exposure of the spinal cord at the vertebral level of thoracic 8-10 (T8-10) and complete transection of the isolated section of spinal cord at T8." ;
rdfs:subClassOf obo:XCO_0001796 .
obo:XCO_0001658 a rdfs:Class ;
rdfs:label "cocaine hydrochloride" ;
rdfs:comment "This is any condition in which the main influencing factor is the hydrochloride salt of cocaine, which is used clinically as a local anesthetic and vasoconstrictor. Cocaine's local anesthetic effects come from it's binding to and blocking of the voltage-gated sodium channels in the neuronal cell membrane. Cocaine also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse." ;
rdfs:subClassOf obo:XCO_0001017 .
obo:XCO_0001430 a rdfs:Class ;
rdfs:label "sciatic nerve crush with decellularization" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimentally controlled sciatic nerve crush and decellularization, which can be achieved by mechanical nerve crush followed by multiple freeze/thaw cycles using controlled application of liquid nitrogen and ambient thawing. This system is used as a model of sciatic neuropathy, Wallerian degeneration, and axonal regeneration." ;
rdfs:subClassOf obo:XCO_0001092 .
obo:XCO_0000969 a rdfs:Class ;
rdfs:label "lateral fluid percussion injury" ;
rdfs:comment "This is an experimental injury condition produced by a pendulum-and-piston-based device applying a brief fluid pressure pulse onto the intact dura after performing a craniectomy on the head of the subject." ;
rdfs:subClassOf obo:XCO_0000968 .
obo:XCO_0000049 a rdfs:Class ;
rdfs:label "visual stimulus" ;
rdfs:comment "Any action or condition designed to cause the registration or perception of a stimulus by the optical sense organs. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." ;
rdfs:subClassOf obo:XCO_0000047 .
obo:XCO_0001664 a rdfs:Class ;
rdfs:label "bismuth subcitrate potassium" ;
rdfs:comment "This is any condition in which the main influencing factor is bismuth subcitrate potassium, a complex salt that is used to treat duodenal and gastric ulcers associated with Helicobacter pylori. Bismuth subcitrate potassium is a soluble, complex bismuth salt of citric acid." ;
rdfs:subClassOf obo:XCO_0001600 .
obo:XCO_0001311 a rdfs:Class ;
rdfs:label "Pkc-IN-1" ;
rdfs:comment "This is any condition in which the main influencing factor is Pkc-IN-1, a potent, ATP-competitive inhibitor of PKCα and PKCβ." ;
rdfs:subClassOf obo:XCO_0000970 .
obo:XCO_0001284 a rdfs:Class ;
rdfs:label "soiled cage" ;
rdfs:comment "This is any condition in which the main influencing factor is a soiled cage, a housing condition designed to create stress in subjects living in such housing. The soiled cage is typically a cage in which excess water has been introduced to the bedding (for example: 200 ml water in 100 g of sawdust bedding)." ;
rdfs:subClassOf obo:XCO_0000033 .
obo:XCO_0000170 a rdfs:Class ;
rdfs:label "fluorescently labeled chemical" ;
rdfs:comment "Chemical to which a fluorescent tag has been added as a tracer." ;
rdfs:subClassOf obo:XCO_0000169 .
obo:XCO_0000056 a rdfs:Class ;
rdfs:label "obsolete naive control condition" ;
rdfs:comment "OBSOLETE. A baseline condition in which none of the experimental manipulations are performed." .
obo:XCO_0000128 a rdfs:Class ;
rdfs:label "obsolete drink with chemical additive" .
obo:XCO_0001551 a rdfs:Class ;
rdfs:label "cellulose nanocrystal" ;
rdfs:comment "This is any condition in which the main influencing factor is cellulose nanocrystals, formed by acid hydrolysis of cellulose. The family of nanocellulosic materials include microfibrilated cellulose, cellulose nanofibers, and cellulose nanocrystals. Cellulose nanocrystals are rod-shaped particles of 100 to 1000 nanometers in length." ;
rdfs:subClassOf obo:XCO_0000338 , obo:XCO_0001550 .
obo:XCO_0001118 a rdfs:Class ;
rdfs:label "experimental unilateral anterior crossbite" ;
rdfs:comment "This is any condition in which the main influencing factor is the use of a prosthetic device to generate a unilateral anterior crossbite in laboratory animals. A unilateral anterior crossbite is a specific type of dental malocclusion that creates temporomandibular joint osteoarthritis via biomechanical stress in the experimental subject or patient." ;
rdfs:subClassOf obo:XCO_0001100 .
obo:XCO_0000593 a rdfs:Class ;
rdfs:label "puromycin aminonucleoside" ;
rdfs:comment "The aminonucleoside portion of the antibiotic puromycin. NOTE: This molecule does not induce apoptosis and does not inhibit protein synthesis." ;
rdfs:subClassOf obo:XCO_0000392 .
obo:XCO_0000499 a rdfs:Class ;
rdfs:label "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine" ;
rdfs:comment "This is any condition in which the main influencing factor is1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the precursor to the toxic metabolite MPP+ (1-methyl-4-phenylpyridinium cation) which promotes degeneration of dopaminergic neurons." ;
rdfs:subClassOf obo:XCO_0000495 , obo:XCO_0000497 .
obo:XCO_0001452 a rdfs:Class ;
rdfs:label "gadodiamide" ;
rdfs:comment "This is any condition in which the main influencing factor is gadodiamide, a gadolinium-based MRI contrast agent (GBCA), used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels." ;
rdfs:subClassOf obo:XCO_0000718 .
obo:XCO_0001237 a rdfs:Class ;
rdfs:label "experimental varicocele" ;
rdfs:comment "This is any condition whose main influencing factor is an experimental varicocele generated by partial ligation of the left renal vein. A varicocele is an abnormal dilation of the pampiniform plexus (veins) of the spermatic cord.." ;
rdfs:subClassOf obo:XCO_0000595 .
obo:XCO_0001862 a rdfs:Class ;
rdfs:label "muscle autograft" ;
rdfs:comment "This is any condition in which the main influencing factor is muscle autograft, implantation of autologous muscle tissue. This is a surgical procedure intended to restore lost or impaired muscle function." ;
rdfs:subClassOf obo:XCO_0001859 .
obo:XCO_0000668 a rdfs:Class ;
rdfs:label "arterial catheter implantation and controlled hemorrhage" ;
rdfs:comment "The insertion of a tubular, flexible surgical instrument into an artery to withdraw a substantial, yet controlled, amount of blood." .
obo:XCO_0000291 a rdfs:Class ;
rdfs:label "peripheral myelin protein 2 peptide 58-81" ;
rdfs:comment "A condition in which the major influencing factor is the peptide (KNTEISFKLGQEFEETTADNRKTK) representing residues 58 to 81 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins." .
obo:XCO_0000089 a rdfs:Class ;
rdfs:label "neoplasm-inducing chemical" ;
rdfs:comment "Any condition in which the main influencing factor is a chemical, i.e., a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, which has the capacity to promote the formation of neoplasms, new and abnormal growths, specifically those in which cell multiplication is uncontrolled and progressive." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0001647 a rdfs:Class ;
rdfs:label "sham gene transfer using an empty adeno-associated virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is an empty adeno-associated virus vector that has been transferred into a cell or organism. This condition is used as a control for a adeno-associated virus transfer of a specific gene. The empty vector is identical to the experimental adeno-associated virus except for the specific gene being tested." ;
rdfs:subClassOf obo:XCO_0000099 , obo:XCO_0001575 .
obo:XCO_0000706 a rdfs:Class ;
rdfs:label "lithium phthalocyanine" ;
rdfs:comment "Physicochemically lithium phthalocyanine is very stable; its response to pO2 does not change with conditions and environments (e.g., pH, temperature, redox conditions) likely to occur in viable biological systems. It is an organic radical compound that forms metallic-organic, paramagnetic crystallites that appear very useful for in vitro and in vivo electron paramagnetic resonance oximetry." ;
rdfs:subClassOf obo:XCO_0000705 .
obo:XCO_0000754 a rdfs:Class ;
rdfs:label "bilateral carotid artery occlusion" ;
rdfs:comment "A surgical manipulation causing blockage of both of the common carotid arteries, or left and right branches (internal or external) of the common carotid arteries." ;
rdfs:subClassOf obo:XCO_0000704 .
obo:XCO_0000309 a rdfs:Class ;
rdfs:label "heated ambient air exposure" ;
rdfs:comment "An activity or condition in which the air surrounding or encircling the organism or isolated organ has a relatively high, or higher than considered normal, temperature, i.e., air in which the molecules possess a higher than normal amount of random kinetic energy." ;
rdfs:subClassOf obo:XCO_0000011 , obo:XCO_0000308 .
obo:XCO_0001685 a rdfs:Class ;
rdfs:label "controlled empagliflozin content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled empagliflozin content diet, a regimen of solid food in which the amount of empagliflozin consumed is controlled. Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporter primarily responsible for the reabsorption of glucose in the kidney. It is used as a hypoglycemic agent for the management of type 2 diabetes mellitus." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001441 a rdfs:Class ;
rdfs:label "processed pyritum hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a metal ion-chelating peptide hydrogel, a hydrogel containing a self-assembling metal ion-chelating peptide (HPGIAQFF) with chelated metal ions (Fe2+, Cu2+, Zn2+, Mn2+, Mg2+, and Ca2) . The metal ions are derived from processed pyritum, a Chinese medicine derived from pyritum disulfide. Hydrogel implants are one of many methods used in bone tissue engineering." .
obo:XCO_0001759 a rdfs:Class ;
rdfs:label "experimental osteoarthritis of the knee joint" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental osteoarthritis of the knee joint. Osteoarthritis can be initiated in rodents via surgical methods, chemical methods, and/or directed injury to cause joint instability." .
obo:XCO_0001631 a rdfs:Class ;
rdfs:label "chelator" ;
rdfs:comment "This is any condition in which the main influencing factor is a chelator, an organic chemical that bonds with and removes free metal ions from solutions. The complex between a metal ion and a chelator is water-soluble and not easily dissociated." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001075 a rdfs:Class ;
rdfs:label "unilateral ureter ligation" ;
rdfs:comment "This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one ureter. Unilateral ureter ligation is used in experimental animals to create a model of unilateral ureteral obstruction and renal fibrosis." ;
rdfs:subClassOf obo:XCO_0001074 .
obo:XCO_0000996 a rdfs:Class ;
rdfs:label "transfer of CHAER1 siRNA using Lipofectamine reagent" ;
rdfs:comment "This is any condition in which the main influencing factor is CHAER1 (cardiac hypertrophy associated epigenetic regulator 1) siRNA (small interfering RNA) transfected by Lipofectamine. Small interfering RNA (siRNA) is a class of double-stranded RNA (20-24bp) that acts in the RNA interference pathway, by interfering with the expression of genes with complementary nucleotide sequence to that of siRNA, inducing mRNA degradation. CHAER1 is an ncRNA involved in epigenetic regulation of gene expression. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0001181 a rdfs:Class ;
rdfs:label "OC43p‐SCR" ;
rdfs:comment "This is any condition in which the major influencing factor is OC43p-SCR, a synthetic peptide whose sequence (VFIAHSVKFTKSFTLATTFA) is a scrambled version of OC43p, a peptide derived from the Human coronavirus OC43 gene ORF1ab/ORF1ab polyprotein. This OC43p‐SCR sequence is used as an experimental control for OC43p." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0001026 a rdfs:Class ;
rdfs:label "spinal nerve ligation" ;
rdfs:comment "This is any condition in which the main influencing factor is the ligation of one or more segmental spinal nerves at a point before the spinal nerve joins a common nerve (most commonly: ligation of L5 and/or L6 nerves which, with L4, make up the sciatic nerve in rats). This is a model of chronic neuropathic pain." ;
rdfs:subClassOf obo:XCO_0001814 .
obo:XCO_0001259 a rdfs:Class ;
rdfs:label "valsartan" ;
rdfs:comment "This is any condition in which the main influencing factor is valsartan, a monocarboxylic acid amide and angiotensin II type 1 receptor blocker that is used to treat hypertension. Valsartan is also used in the management of heart failure and type 2 diabetes-associated nephropathy." ;
rdfs:subClassOf obo:XCO_0000536 .
obo:XCO_0001695 a rdfs:Class ;
rdfs:label "gestational maternal exposure to housing with intruder-resident paradigm" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to housing with intruder-resident paradigm. This is a condition typically studied to determine the effect of maternal (F0) housing with intruder-resident paradigm exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001694 .
obo:XCO_0000384 a rdfs:Class ;
rdfs:label "controlled tempol content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of tempol consumed by an organism as part of an experiment. Tempol (4-Hydroxy-TEMPO) is a heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001366 a rdfs:Class ;
rdfs:label "DMEM/F-12" ;
rdfs:comment "This is any condition in which the main influencing factor is DMEM/F-12, a widely used basal medium for supporting the growth of many different mammalian cells. DMEM/F-12 is a 1:1 mixture of DMEM and Ham's F-12. This formulation combines DMEM's high concentrations of glucose, amino acids, and vitamins with F-12's wide variety of components. DMEM/F-12 uses a sodium bicarbonate buffer system and therefore requires a 5?10% CO2 environment to maintain physiological pH." .
obo:XCO_0001699 a rdfs:Class ;
rdfs:label "collapsin response mediator protein 1" ;
rdfs:comment "This is any condition in which the main influencing factor is collapsin response mediator protein 1 (CRMP1), a cytosolic phosphoprotein expressed exclusively in the nervous system and probably involved in neural development." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0001485 a rdfs:Class ;
rdfs:label "L4/L5 spinous process resection" ;
rdfs:comment "This is any condition in which the main influencing factor is L4/L5 spinous process resection, an experimental procedure done to induce lumbar spine mechanical instability (LSI) in laboratory animals. The process involves removing the spinous processes along with the supraspinous and interspinous ligaments from lumbar vertebrae L4 and L5." .
obo:XCO_0000720 a rdfs:Class ;
rdfs:label "laser photocoagulation" ;
rdfs:comment "A condition involving eye surgery using a laser to shrink or destroy abnormal structures in the retina, or to intentionally cause scarring." ;
rdfs:subClassOf obo:XCO_0000165 , obo:XCO_0000804 .
obo:XCO_0000735 a rdfs:Class ;
rdfs:label "paclitaxel" ;
rdfs:comment "A tetracyclic diterpenoid which is a mitotic inhibitor used in cancer chemotherapy." ;
rdfs:subClassOf obo:XCO_0000435 .
obo:XCO_0001390 a rdfs:Class ;
rdfs:label "CGG hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a CGG hydrogel, a biomimetic hydrogel composed of gelatin and chitosan networks covalently cross-linked by genipin. Additional components added to these gel scaffolds are intended to increase mechanical performance and the migration, proliferation, and osteodifferentiation of endogenous mesenchymal stem cells (MSCs). Hydrogel implants are one of many methods used in bone tissue engineering." ;
rdfs:subClassOf obo:XCO_0001439 .
obo:XCO_0000689 a rdfs:Class ;
rdfs:label "vitamin C" ;
rdfs:comment "Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. Humans, unlike most animals, are unable to synthesize vitamin C endogenously, so it is an essential dietary component." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000377 .
obo:XCO_0000516 a rdfs:Class ;
rdfs:label "metoprolol succinate" ;
rdfs:comment "A condition in which the main influencing factor is metoprolol succinate, an extended-release formulation of metoprolol. Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches." ;
rdfs:subClassOf obo:XCO_0000514 .
obo:XCO_0001799 a rdfs:Class ;
rdfs:label "human menstrual blood-derived mesenchymal stem cell gelatin hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a hydrogel implanted with human menstrual blood-derived mesenchymal stem cells in the form of single cells." ;
rdfs:subClassOf obo:XCO_0001798 .
obo:XCO_0000180 a rdfs:Class ;
rdfs:label "non-ionizing ultraviolet radiation exposure" ;
rdfs:comment "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 120 and 400 nm. Radiation (i.e. ultraviolet light) at this wavelength does not have sufficient energy to liberate electrons from atoms or molecules although it can induce photochemical reactions, or accelerate radical reactions." ;
rdfs:subClassOf obo:XCO_0000042 , obo:XCO_0000044 .
obo:XCO_0000044 a rdfs:Class ;
rdfs:label "non-ionizing radiation exposure" ;
rdfs:comment "The condition of being subjected to transmitted energy that does not carry enough energy per quantum to completely remove an electron from an atom or molecule. Such radiation has sufficient energy only for excitation, the movement of an electron to a higher energy state." ;
rdfs:subClassOf obo:XCO_0000045 .
obo:XCO_0000937 a rdfs:Class ;
rdfs:label "right kidney denervation" ;
rdfs:comment "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the right side of the body. It is followed by painting of the right side renal blood vessels with a solution of 10% phenol." ;
rdfs:subClassOf obo:XCO_0000935 .
obo:XCO_0000646 a rdfs:Class ;
rdfs:label "azoxymethane" ;
rdfs:comment "This is any condition in which the main influencing factor is azoxymethane (AOM), a gene mutation agent that may be used with dextran sulfate sodium (DSS) to create colon cancer models in laboratory animals." ;
rdfs:subClassOf obo:XCO_0000089 .
obo:XCO_0000211 a rdfs:Class ;
rdfs:label "controlled sucrose content diet" ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000620 a rdfs:Class ;
rdfs:label "vinblastine" ;
rdfs:comment "Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis." ;
rdfs:subClassOf obo:XCO_0000435 .
obo:XCO_0001086 a rdfs:Class ;
rdfs:label "TRV023" ;
rdfs:comment "This is any condition in which the main influencing factor is TRV023, an angiotensin analogue which is a beta-arrestin selective signaling AGTR1 agonist. It is a biased ligand because it does not affect G-protein signaling by AGTR1." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000989 a rdfs:Class ;
rdfs:label "fetal bovine serum" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is fetal bovine serum. Fetal bovine serum is the most widely used serum-supplement for the in vitro cell culture of eukaryotic cells. Fetal bovine serum is derived from the blood drawn from a bovine fetus via a closed system of collection at a slaughterhouse." .
obo:XCO_0000749 a rdfs:Class ;
rdfs:label "phosphoramidon" ;
rdfs:comment "Any condition in which the main influencing factor is phosphoramidon, a potent inhibitor of thermolysin and other metallo-endopeptidases, isolated from the cultures of Streptomyces tanashiensis." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000748 .
obo:XCO_0000641 a rdfs:Class ;
rdfs:label "myocardial reperfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is myocardial reperfusion, any situation in which the flow of blood to the heart is restored after a period of blood vessel occlusion occurring experimentally." ;
rdfs:subClassOf obo:XCO_0000640 .
obo:XCO_0000860 a rdfs:Class ;
rdfs:label "anti-rh-VEGF165 monoclonal antibody" ;
rdfs:comment "A condition in which the main influencing factor is a monoclonal antibody having specific amino acid sequences with the ability to adhere to and interact specifically with recombinant human vascular endothelial growth factor 165." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0001788 a rdfs:Class ;
rdfs:label "extracorporeal circulating blood transfusion with UTOpiA" ;
rdfs:comment "This is any condition in which the main influencing factor is extracorporeal circulating blood transfusion with UTOpiA, a two filter process that involves inline granulocyte-monocyte apheresis (GMA) followed by an inline filter containing HLA-modified human induced pluripotent stem cell-derived hepatocyte-like cell (iHLC) organoids. The combined components of the circuit define a bioartificial liver system that manages inflammation, restores liver function, and promotes regeneration in rat models of severe liver failure." ;
rdfs:subClassOf obo:XCO_0001787 .
obo:XCO_0000320 a rdfs:Class ;
rdfs:label "hexamethonium" ;
rdfs:comment "Either of two compounds (C12H30Br2N2 or C12H30Cl2N2) used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself." ;
rdfs:subClassOf obo:XCO_0000842 .
obo:XCO_0001046 a rdfs:Class ;
rdfs:label "Dnmt3a gapmer antisense oligonucleotide" ;
rdfs:comment "This is any condition in which the main influencing factor is a Dnmt3a gapmer (Dnmt3a-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence." ;
rdfs:subClassOf obo:XCO_0000234 .
obo:XCO_0001794 a rdfs:Class ;
rdfs:label "T2 spinal cord contusion" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy of the second thoracic vertebra and delivery of a controlled contusion of the spinal cord by a mechanical apparatus." ;
rdfs:subClassOf obo:XCO_0001041 .
obo:XCO_0001037 a rdfs:Class ;
rdfs:label "Mycobacterium tuberculosis H37Ra" ;
rdfs:comment "This is any condition in which the main influencing factor is Mycobacterium tuberculosis H37Ra (a high G+C gram-positive bacteria) introduced externally or internally, alive or dead, to a subject to effect a change in phenotype of the subject. Mycobacterium tuberculosis H37Ra is an avirulent strain derived from its virulent parent strain H37." ;
rdfs:subClassOf obo:XCO_0001212 .
obo:XCO_0000955 a rdfs:Class ;
rdfs:label "controlled glucosamine - alendronate content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine - alendronate in which the amount of glucosamine - alendronate consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000943 , obo:XCO_0000944 .
obo:XCO_0001254 a rdfs:Class ;
rdfs:label "troglitazone" ;
rdfs:comment "This is any condition in which the main influencing factor is troglitazone, a hypoglycemic agent that was taken off the market due to hepatotoxicity issues. Troglitazone is also an antioxidant, a vasodilator agent, an anticonvulsant, an anticoagulant, an antineoplastic agent, and a long-chain-fatty-acid--CoA ligase inhibitor." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000271 , obo:XCO_0000407 , obo:XCO_0000435 , obo:XCO_0000523 , obo:XCO_0000950 , obo:XCO_0001090 .
obo:XCO_0001625 a rdfs:Class ;
rdfs:label "controlled RG2833 content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a diet made up of standard chow and a specified amount of RG2833, a brain-penetrant histone deacetylase 1/3 (HDAC1/3) inhibitor." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000839 a rdfs:Class ;
rdfs:label "finerenone" ;
rdfs:comment "Any condition in which the main influencing factor is finerenone, a nonsteroidal mineralocorticoid receptor antagonist." ;
rdfs:subClassOf obo:XCO_0000838 .
obo:XCO_0000657 a rdfs:Class ;
rdfs:label "antiviral agent" ;
rdfs:comment "A substance that kills or slows the growth of a virus." ;
rdfs:subClassOf obo:XCO_0000482 .
obo:XCO_0000485 a rdfs:Class ;
rdfs:label "Haemophilus influenzae 86-028NP H2 mutant" ;
rdfs:comment "A condition in which the primary influencing factor is the H2 mutant of the 86-028NP strain of Haemophilus influenzae." ;
rdfs:subClassOf obo:XCO_0000481 .
obo:XCO_0001006 a rdfs:Class ;
rdfs:label "transfer of negative control siRNA using pSUPER plasmid" ;
rdfs:comment "This is any condition in which the main influencing factor is negative control siRNA delivered with a pSUPER plasmid. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used." ;
rdfs:subClassOf obo:XCO_0001510 .
obo:XCO_0001665 a rdfs:Class ;
rdfs:label "running on inclined treadmill with shock grid" ;
rdfs:comment "This is any condition in which the main influencing factor is running on an inclined treadmill with shock grid, a set-up designed to force the subject to continue moving on the treadmill. If the subject stops forward movement, the shock grid will be encountered at the back end of the treadmill. The apparatus is designed to make the subject run/walk until exhausted" ;
rdfs:subClassOf obo:XCO_0000296 .
obo:XCO_0000033 a rdfs:Class ;
rdfs:label "housing condition" ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000164 a rdfs:Class ;
rdfs:label "controlled sodium content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of sodium, i.e. sodium ions, consumed by an organism as part of an experiment. A sodium ion is an atom of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0000254 .
obo:XCO_0001479 a rdfs:Class ;
rdfs:label "controlled ex vivo liver perfusion" ;
rdfs:comment "This is an experimental condition consisting of perfusion (recirculated or single pass) of the isolated liver with some physiological buffer (consisting of controlled solute composition and specific flow rate) through the liver portal vein and/or hepatic artery.." ;
rdfs:subClassOf obo:XCO_0001478 .
obo:XCO_0000555 a rdfs:Class ;
rdfs:label "controlled lisinopril content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of lisinopril consumed by an organism as part of an experiment." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001097 a rdfs:Class ;
rdfs:label "JZL184" ;
rdfs:comment "This is any condition in which the main influencing factor is JZL184, an irreversible inhibitor of monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol (2-AG)." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0000207 a rdfs:Class ;
rdfs:label "3-methyl-4'-dimethylaminoazobenzene" ;
rdfs:comment "A condition in which the main influencing factor is 3-methyl-4'-dimethylaminoazobenzene (MDAB), an azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. MDAB is a potent liver carcinogen." ;
rdfs:subClassOf obo:XCO_0000089 .
obo:XCO_0000085 a rdfs:Class ;
rdfs:label "stationary bicycle dynamometer" ;
rdfs:subClassOf obo:XCO_0000063 .
obo:XCO_0001812 a rdfs:Class ;
rdfs:label "controlled pterostilbene content, CDAA diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a choline‐deficient, amino acid‐defined (CDAA) diet with controlled pterostilbene content." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001845 a rdfs:Class ;
rdfs:label "sciatic nerve constriction" ;
rdfs:comment "This is any condition in which the main influencing factor is sciatic nerve constriction, in which multiple loose ligatures are placed around the sciatic nerve. It is used as a model for neuropathic pain." ;
rdfs:subClassOf obo:XCO_0001814 .
obo:XCO_0001535 a rdfs:Class ;
rdfs:label "PEG-fusion protocol" ;
rdfs:comment "This is any condition in which the main influencing factor is the PEG-fusion protocol, a peripheral nerve allograft procedure involving sequential administration of four pharmaceutical agents and neurorrhaphy (microsutures through the epi- or perineurium)." ;
rdfs:subClassOf obo:XCO_0001534 .
obo:XCO_0000272 a rdfs:Class ;
rdfs:label "tempol" ;
rdfs:comment "A heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide." ;
rdfs:subClassOf obo:XCO_0000271 .
obo:XCO_0000145 a rdfs:Class ;
rdfs:label "phenylephrine" ;
rdfs:comment "A selective alpha1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and as a vasoconstrictor." ;
rdfs:subClassOf obo:XCO_0000141 , obo:XCO_0000673 .
obo:XCO_0000836 a rdfs:Class ;
rdfs:label "gene transfer of the HSV-tk gene using an adenovirus vector" ;
rdfs:comment "A condition in which the herpes simplex virus thymidine kinase (HSV-tk) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000175 a rdfs:Class ;
rdfs:label "tritiated inulin" ;
rdfs:comment "Inulin, a fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration, into which the mass 3 radioactive isotope of hydrogen has been incorporated as a tracer." ;
rdfs:subClassOf obo:XCO_0000171 , obo:XCO_0000174 .
obo:XCO_0000247 a rdfs:Class ;
rdfs:label "controlled olive oil content diet" ;
rdfs:comment "A regimen of solid food to which a specified amount of olive oil has been added." ;
rdfs:subClassOf obo:XCO_0000454 .
obo:XCO_0001377 a rdfs:Class ;
rdfs:label "experimental spinal cord transection at T10/T11 sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental spinal cord transection sham procedure at T10/T11, which follows the same surgical process through laminectomy, but no spinal cord transection occurs." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0001748 a rdfs:Class ;
rdfs:label "ibuprofen" ;
rdfs:comment "This is any condition in which the main influencing factor is ibuprofen, a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group. It is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0001399 a rdfs:Class ;
rdfs:label "sevoflurane" ;
rdfs:comment "This is any condition in which the main influencing factor is sevoflurane, an ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups. Sevoflurane is a non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent platelet aggregation." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0001196 .
obo:XCO_0000890 a rdfs:Class ;
rdfs:label "ionophore" ;
rdfs:comment "A compound that facilitates transmission of an ion across a lipid barrier (as in a cell membrane) by combining with the ion or by increasing the permeability of the barrier to it." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001030 a rdfs:Class ;
rdfs:label "acupuncture" ;
rdfs:comment "This is any condition in which the main influencing factor is acupuncture, a technique in which practitioners insert fine needles into the skin to treat health problems. The needles may be manipulated manually or stimulated with small electrical currents (electroacupuncture). Acupuncture has been in use in some form for at least 2,500 years." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000400 a rdfs:Class ;
rdfs:label "surgical avulsion" ;
rdfs:comment "A surgical manipulation in which one tissue, organ or body part is forcibly torn away from the whole, or in which an attached or anchored tissue is torn away from another tissue or body part." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000191 a rdfs:Class ;
rdfs:label "angiotensin II" ;
rdfs:comment "The 8 amino acid cleavage product produced by the action of angiotensin-converting enzyme (ACE) on Ang I. Ang II is considered to be the main effector of the renin-angiotensin system (RAS), has endocrine, autocrine/paracrine, and intracrine hormone activities in the body and acts as a powerful vasoconstrictor." ;
rdfs:subClassOf obo:XCO_0000126 .
obo:XCO_0001050 a rdfs:Class ;
rdfs:label "T8/T9 laminectomy" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) from both the eighth and the ninth thoracic vertebrae." .
obo:XCO_0000877 a rdfs:Class ;
rdfs:label "Hespan buffer" ;
rdfs:comment "This is any condition in which the main influencing factor is Hespan buffer, 6% hetastarch in buffered solution. A buffer is a homogeneous mixture of molecules, atoms and/or ions, one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed in a sufficient quantity of solvent." ;
rdfs:subClassOf obo:XCO_0000315 .
obo:XCO_0001524 a rdfs:Class ;
rdfs:label "multigenerational paternal exposure to controlled air oxygen content" ;
rdfs:comment "This is any condition in which the main influencing factor is any paternal exposure to controlled air oxygen content that has multigenerational effects. This is a condition typically studied to determine the effect of paternal (F0) controlled air oxygen content exposure on the F1 offspring. The paternal exposure may be any time before conception of offspring." ;
rdfs:subClassOf obo:XCO_0001525 .
obo:XCO_0000961 a rdfs:Class ;
rdfs:label "controlled ex vivo heart condition" ;
rdfs:comment "This is an experimental condition in which the internal or external environment of a heart is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." ;
rdfs:subClassOf obo:XCO_0000464 .
obo:XCO_0000562 a rdfs:Class ;
rdfs:label "salidroside" ;
rdfs:comment "This is any condition in which the main influencing factor is salidroside, a glucoside of tyrosol found in the plant Rhodiola rosea. It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant." ;
rdfs:subClassOf obo:XCO_0000561 , obo:XCO_0001122 .
obo:XCO_0000523 a rdfs:Class ;
rdfs:label "enzyme inhibitor" ;
rdfs:comment "This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of an enzyme, a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0001198 a rdfs:Class ;
rdfs:label "nitrofurantoin" ;
rdfs:comment "This is any condition in which the main influencing factor is nitrofurantoin, a urinary anti-bacterial agent effective against most gram-positive and gram-negative organisms. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0001129 a rdfs:Class ;
rdfs:label "carboxymethylcellulose" ;
rdfs:comment "This is any condition in which the main influencing factor is carboxymethylcellulose, a polysaccharide derivative that is cellulose in which carboxymethyl groups are bound to some of the hydroxyl groups of the glucopyranose monomers." ;
rdfs:subClassOf obo:XCO_0001128 , obo:XCO_0001232 .
obo:XCO_0001688 a rdfs:Class ;
rdfs:label "allogeneic platelet-rich plasma" ;
rdfs:comment "This is any condition in which the main influencing factor is allogeneic platelet-rich plasma, a concentrate of non-self plasma derived from whole blood (centrifuged to remove red blood cells but retaining platelets). PRP (platelet-rich plasma) contains multiple growth factors and other cytokines that can stimulate the healing of soft tissues and joints." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001496 a rdfs:Class ;
rdfs:label "gestational maternal exposure to 17alpha-ethynylestradiol" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to 17alpha-ethynylestradiol. This is a condition typically studied to determine the effect of maternal (F0) 17alpha-ethynylestradiol use/exposure on the F1 offspring" ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001493 .
obo:XCO_0001340 a rdfs:Class ;
rdfs:label "human skin-derived ABCB5+ stromal cells" ;
rdfs:comment "This is any condition in which the main influencing factor is human, skin-derived ABCB5+ stromal cells, which are ABCB5-positive mesenchymal stem cells (MSCs) isolated from skin of healthy adult donors and can be expanded in culture. ABCB5+ MSCs are used in therapy for chronic wounds and other skin diseases." ;
rdfs:subClassOf obo:XCO_0001393 .
obo:XCO_0001248 a rdfs:Class ;
rdfs:label "poloxamers" ;
rdfs:comment "This is any condition in which the main influencing factor is poloxamers, nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The length of the copolymer chains can be varied to alter the properties of the whole molecule." ;
rdfs:subClassOf obo:XCO_0000757 , obo:XCO_0001232 .
obo:XCO_0001614 a rdfs:Class ;
rdfs:label "urokinase-loaded nano-patrols" ;
rdfs:comment "This is any condition in which the main influencing factor is urokinase-loaded nano-patrols, which are mesoporous polydopamine nanoparticles which have been loaded with human urokinase and coated with three different single-stranded DNAs to function as thrombin aptamers, pore sealers, and release biomarkers. These specialized nanoparticles are used for regulating therapeutic urokinase dose based on the in vivo thrombolysis resistance of thrombi." ;
rdfs:subClassOf obo:XCO_0001090 .
obo:XCO_0001717 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to lactate dehydrogenase B MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to an autoantibody-generating level of lactate dehydrogenase B (LDHB) multiple antigenic peptides (MAPs) that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) LDHB exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001720 .
obo:XCO_0001681 a rdfs:Class ;
rdfs:label "controlled butane-1,3-diol content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of butane-1,3-diol consumed by an organism as part of an experiment. Butane-1,3-diol is a butanediol commonly used as a solvent for flavoring agents and is a co-monomer used in certain polyurethane and polyester resins. It is also used as a hypoglycemic agent." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000926 a rdfs:Class ;
rdfs:label "polyethylene glycol" ;
rdfs:comment "This is any condition in which the main influencing factor is a polyether compound, composed of repeating ethyleneoxy units, and derived from petroleum. Polyethylene glycol has many applications, including medical uses like in the composition of some laxatives." ;
rdfs:subClassOf obo:XCO_0000927 .
obo:XCO_0001187 a rdfs:Class ;
rdfs:label "ampicillin" ;
rdfs:comment "This is any condition in which the main influencing factor is ampicillin, a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group." ;
rdfs:subClassOf obo:XCO_0001202 .
obo:XCO_0000512 a rdfs:Class ;
rdfs:label "teratogen" ;
rdfs:comment "Any condition in which the main influencing factor is a substance with adverse or toxic effects on an embryo or fetus resulting in birth defects, specifically, altered development, growth retardation, functional defect and/or embryo death." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0001243 a rdfs:Class ;
rdfs:label "wind" ;
rdfs:comment "This is any condition in which the major influencing factor is wind, the movement of air of any velocity, especially an experimentally controlled velocity. The air may be ambient or otherwise controlled." .
obo:XCO_0000858 a rdfs:Class ;
rdfs:label "rat anti-control-Ab2 T cells" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies." ;
rdfs:subClassOf obo:XCO_0000763 .
obo:XCO_0000884 a rdfs:Class ;
rdfs:label "trypan blue" ;
rdfs:comment "Any condition in which the main influencing factor is trypan blue, an azo dye used as a vital stain to selectively colour dead tissues or cells blue." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000512 .
obo:XCO_0001057 a rdfs:Class ;
rdfs:label "corticosterone" ;
rdfs:comment "This is any condition in which the main influencing factor is corticosterone, a 21-carbon adrenocortical steroid hormone that has modest but significant activities as both a mineralocorticoid and a glucocorticoid." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0001064 a rdfs:Class ;
rdfs:label "5/6 nephrectomy" ;
rdfs:comment "This is any condition in which the main influencing factor is a 5/6 nephrectomy, which is an experimental procedure performed to produce an animal model of chronic kidney disease in rodents. Typically, the right kidney is removed and the poles of the left kidney are removed to produce a total renal system which is 1/6 of original capacity. The animal is typically allowed to recover for a week between the total and partial nephrectomy." ;
rdfs:subClassOf obo:XCO_0000017 .
obo:XCO_0000325 a rdfs:Class ;
rdfs:label "ethanol" ;
rdfs:comment "Any condition in which the main influencing factor is ethanol, a primary alcohol with chemical formula CH3-CH2-OH, that is ethane in which one of the hydrogens is substituted by a hydroxy group." ;
rdfs:subClassOf obo:XCO_0000324 .
obo:XCO_0001718 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to lactate dehydrogenase B MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to an autoantibody-generating level of lactate dehydrogenase B (LDHB) multiple antigenic peptides (MAPs). This is a condition typically studied to determine the effect of maternal (F0) LDHB exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001717 .
obo:XCO_0000463 a rdfs:Class ;
rdfs:label "dark phase of controlled light/dark cycle" ;
rdfs:comment "This is any condition in which the main influencing factor is the part of a controlled light/dark cycle when the subject is not being exposed to ambient light (that is, during the dark phase of the cycle). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences periods of controlled ambient light followed by periods of darkness." ;
rdfs:subClassOf obo:XCO_0000459 .
obo:XCO_0000139 a rdfs:Class ;
rdfs:label "vasoactive chemical" ;
rdfs:comment "A condition in which the main influencing factor is a molecule that directly or indirectly acts upon blood vessels to cause constriction or dilation." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:MESH_D013844 a rdfs:Class .
obo:XCO_0001529 a rdfs:Class ;
rdfs:label "gestational maternal exposure to citrate buffer" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to citrate buffer. This is a condition typically studied to determine the effect of maternal (F0) citrate buffer exposure on the F1 offspring. This is typically a control condition for gestational maternal exposure to some chemical agent." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001528 .
obo:XCO_0001017 a rdfs:Class ;
rdfs:label "cocaine" ;
rdfs:comment "This is a bitter crystalline alkaloid C17H21NO4 obtained from coca leaves that is used especially in the form of its hydrochloride medically as a topical anesthetic and illicitly for its euphoric effects and that may result in a compulsive psychological need." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000141 , obo:XCO_0000511 , obo:XCO_0000618 .
obo:XCO_0000908 a rdfs:Class ;
rdfs:label "potassium aluminium sulfate" ;
rdfs:comment "A condition in which the main influencing factor is a metal sulfate composed of potassium, aluminium and sulfate ions in the ratio 1:1:2." ;
rdfs:subClassOf obo:XCO_0000909 .
obo:XCO_0001276 a rdfs:Class ;
rdfs:label "bromobenzene" ;
rdfs:comment "This is any condition in which the main influencing factor is bromobenzene, the simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. Bromobenzene is used as a solvent, particularly for large-scale crystallizations, and for the introduction of phenyl groups in organic synthesis." ;
rdfs:subClassOf obo:XCO_0001231 .
obo:XCO_0000534 a rdfs:Class ;
rdfs:label "sunitinib" ;
rdfs:comment "A condition in which the main influencing factor is sunitinib, an antineoplastic agent which acts as a receptor tyrosine kinase inhibitor and an antagonist for multiple platelet-derived growth factor and vascular endothelial growth factor receptors. Sunitinib is used as a chemotherapy agent in the treatment of renal cell carcinoma and gastrointestinal stromal tumor." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0000435 , obo:XCO_0000970 .
obo:XCO_0000222 a rdfs:Class ;
rdfs:label "cation channel inhibitor" ;
rdfs:comment "Any chemical substance which decreases or interferes with the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000221 .
obo:XCO_0001737 a rdfs:Class ;
rdfs:label "simvastatin" ;
rdfs:comment "This is any condition in which the main influencing factor is simvastatin, a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0000523 , obo:XCO_0000680 .
obo:XCO_0000314 a rdfs:Class ;
rdfs:label "buffer" ;
rdfs:comment "Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001090 a rdfs:Class ;
rdfs:label "anticoagulant" ;
rdfs:comment "This is any condition in which the main influencing factor is an anticoagulant, a substance that hinders the clotting of blood." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0000277 a rdfs:Class ;
rdfs:label "cyclic hydrocarbon" ;
rdfs:comment "Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form a continuous or closed chain linked by bonds that may be represented graphically by one or more circular or triangular forms." ;
rdfs:subClassOf obo:XCO_0000276 .
obo:XCO_0001265 a rdfs:Class ;
rdfs:label "stress" ;
rdfs:comment "This is any condition in which the main influencing factor is stress, which is a physical, chemical, or emotional factor that causes bodily or mental tension and may be a factor in disease causation." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000895 a rdfs:Class ;
rdfs:label "controlled cyclodextrin (CD)-clathrated hesperetin content diet" ;
rdfs:comment "A regimen of solid food in which the amount of cyclodextrin (CD)-clathrated hesperetin is controlled. CD-clathrated hesperetin is the aglycone of hesperidin. Clathration by CD enhances hesperetin solubility." ;
rdfs:subClassOf obo:XCO_0000725 , obo:XCO_0000896 .
obo:XCO_0001569 a rdfs:Class ;
rdfs:label "maternal exposure to 6-propyl-2-thiouracil during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to 6-propyl-2-thiouracil during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) 6-propyl-2-thiouracil use/exposure during the postnatal, preweaning period on the F1 offspring." .
obo:XCO_0001692 a rdfs:Class ;
rdfs:label "gestational maternal exposure to MitoQ-NP" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to MitoQ-NP (nanoparticle-bound mitoquinone). This is a condition typically studied to determine the effect of maternal (F0) MitoQ-NP use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001691 .
obo:XCO_0001620 a rdfs:Class ;
rdfs:label "Yuanhu Zhitong Prescription" ;
rdfs:comment "This is any condition in which the main influencing factor is Yuanhu Zhitong Prescription, a traditional Chinese medicine (TCM) formula used for pain relief. The main ingredients of Yuanhu Zhitong Prescription are Radix angelicae dahuricae (white angelica root) and Rhizoma corydalis (gold thread rhizome)." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0001623 .
obo:XCO_0000713 a rdfs:Class ;
rdfs:label "desmopressin" ;
rdfs:comment "A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. Its action is mediated by the vasopressin receptor V2. It has prolonged antidiuretic activity, but little pressor effects." ;
rdfs:subClassOf obo:XCO_0000228 , obo:XCO_0000712 .
obo:XCO_0001388 a rdfs:Class ;
rdfs:label "IFA-CII emulsion" ;
rdfs:comment "This is any condition in which the major influencing factor is an IFA-CII emulsion, a combination of the oil-based incomplete Freund's adjuvant and acetic acid-soluble type II collagen (usually bovine). IFA induces a predominantly Th2-biased inflammatory response through the formation of a depot at the injection site and the stimulation of antibody producing plasma cells." ;
rdfs:subClassOf obo:XCO_0000281 .
obo:XCO_0000214 a rdfs:Class ;
rdfs:label "activator" ;
rdfs:comment "Any substance that makes another substance active or reactive, induces a chemical reaction, or combines with an enzyme to increase its catalytic activity." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001654 a rdfs:Class ;
rdfs:label "suckling" ;
rdfs:comment "This is any condition in which the main influencing factor is suckling, that act of feeding on or being fed by milk directly from a mother's breast/mammary glands." .
obo:XCO_0000597 a rdfs:Class ;
rdfs:label "abdominal aorta constriction" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical narrowing of the lumen of the abdominal aorta. The abdominal aorta consists of the suprarenal abdominal aorta and the infrarenal aorta." ;
rdfs:subClassOf obo:XCO_0000596 .
obo:XCO_0000664 a rdfs:Class ;
rdfs:label "adrenergic receptor agonist" ;
rdfs:comment "An agent that selectively binds to and activates adrenergic receptors." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0001852 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to controlled content liquid ethanol diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to a controlled ethanol content liquid diet that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) controlled ethanol content liquid diet exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001851 .
obo:XCO_0000972 a rdfs:Class ;
rdfs:label "nintedanib" ;
rdfs:comment "This is any condition in which the main influencing factor is the chemical nintedanib, a member of the class of oxindoles that is a multi-kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and cancer." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000970 .
obo:XCO_0001004 a rdfs:Class ;
rdfs:label "uniform magnetic field" ;
rdfs:comment "This is any condition in which the main influencing factor is a uniform magnetic field. A uniform magnetic field may be generated by an apparatus such as a Halbach cylinder. A Halbach cylinder is a magnetized cylinder composed of ferromagnetic material which can produce a uniform magnetic field across a plate of cultured cells which is surrounded by the cylinder." ;
rdfs:subClassOf obo:XCO_0001003 .
obo:XCO_0000030 a rdfs:Class ;
rdfs:label "controlled protein content diet" ;
rdfs:comment "A regimen of solid food in which the amount of protein consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001603 a rdfs:Class ;
rdfs:label "icariin" ;
rdfs:comment "This is any condition in which the main influencing factor is icariin, a flavonoid compound found in plants of the genus Epimedium. Icarin is the major flavonoid responsible for the pharmacological actions of Epimedii Herb, used in traditional Chinese medicine." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000505 .
obo:XCO_0001777 a rdfs:Class ;
rdfs:label "CM5480" ;
rdfs:comment "This is any condition in which the main influencing factor is CM5480, a selective inhibitor for Orai1, a protein crucial for store-operated calcium entry and calcium release-activated calcium (CRAC) channel function." ;
rdfs:subClassOf obo:XCO_0000269 .
obo:XCO_0000674 a rdfs:Class ;
rdfs:label "clonidine" ;
rdfs:comment "This is any condition in which the main influencing factor is clonidine, an imidazoline sympatholytic agent that stimulates alpha-2 adrenergic receptors and central imidazoline receptors. It is commonly used in the management of hypertension." ;
rdfs:subClassOf obo:XCO_0000673 , obo:XCO_0000863 .
obo:XCO_0000197 a rdfs:Class ;
rdfs:label "indicator" ;
rdfs:comment "Any substance that indicates the presence, absence, or concentration of another substance or the degree of reaction between substances by means of a characteristic change, especially in color." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001468 a rdfs:Class ;
rdfs:label "minocycline" ;
rdfs:comment "This is any condition in which the main influencing factor is minocycline, a semi-synthetic second-generation tetracycline and a broad-spectrum antibiotic. Minocycline has a dimethylamino group at position 7 and lacks the methyl and hydroxy groups at position 5, which makes it effective against tetracycline-resistant staphylococcus infections." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000672 .
obo:XCO_0001641 a rdfs:Class ;
rdfs:label "2,2′,5,5′-tetrachlorobiphenyl-4-ol" ;
rdfs:comment "This is any condition in which the main influencing factor is 2,2′,5,5′-tetrachlorobiphenyl-4-ol, a metabolite of the polychlorinated biphenyl (PCB) compound PCB52. 2,2′,5,5′-tetrachlorobiphenyl-4-ol is formed when the human body metabolizes PCB52" ;
rdfs:subClassOf obo:XCO_0001572 .
obo:XCO_0000225 a rdfs:Class ;
rdfs:label "potassium channel inhibitor" ;
rdfs:comment "Any chemical substance which decreases or interferes with the activity of a potassium ion channel, that is, a complex of membrane-bound and membrane-spanning proteins that specifically allow diffusion of positively charged potassium ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000222 .
obo:XCO_0000803 a rdfs:Class ;
rdfs:label "subthreshold laser therapy" ;
rdfs:comment "Subthreshold therapy is photocoagulation that does not produce clinical or histologic evidence of retinal damage. Therapeutic benefit is thought to be derived by inducing thermal stress on RPE cells. The goal of the subthreshold therapy is to maintain the temperature rise below the threshold of irreversible thermal damage. The main types are micropulse, selective retinal therapy (SRT), and continuous wave laser with EndPoint Management (algorithm/protocol)." ;
rdfs:subClassOf obo:XCO_0000720 .
obo:XCO_0001643 a rdfs:Class ;
rdfs:label "beta-aminopropionitrile" ;
rdfs:comment "This is any condition in which the main influencing factor is beta-aminopropionitrile, an organic compound with both amine and nitrile functional groups. Beta-aminopropionitrile is an antineoplastic agent, an antirheumatic drug, and an inhibitor of lysyl oxidase, an enzyme involved in collagen and elastin cross-linking." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0000758 a rdfs:Class ;
rdfs:label "retinoic acid" ;
rdfs:comment "Condition in which the main influencing factor is retinoic acid, a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). Retinoic acid is derived from retinol (vitamin A) and plays important roles in cell growth, differentiation, and organogenesis." ;
rdfs:subClassOf obo:XCO_0000468 .
obo:XCO_0000236 a rdfs:Class ;
rdfs:label "pathogen" ;
rdfs:comment "An biological agent that causes disease, especially a living microorganism such as a bacterium, virus, or fungus." ;
rdfs:subClassOf obo:XCO_0000258 .
obo:XCO_0001863 a rdfs:Class ;
rdfs:label "ex vivo ischemic heart condition" ;
rdfs:comment "This is any condition in which the main influencing factor is ischemia of an ex vivo heart, a heart that has been removed from an organism, but not oxygenated by perfusion or other means." ;
rdfs:subClassOf obo:XCO_0000961 .
obo:XCO_0000882 a rdfs:Class ;
rdfs:label "sleeve gastrectomy" ;
rdfs:comment "This procedure involves removal of about 80% of the stomach, leaving a tube-shaped stomach about the size and shape of a banana. The procedure is typically performed as a surgical intervention for weight control." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000106 a rdfs:Class ;
rdfs:label "anesthetic/analgesic" ;
rdfs:comment "This is any condition in which the main influencing factor is a drug or agent used to reduce or eliminate pain or sensation." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0000493 a rdfs:Class ;
rdfs:label "controlled exposure to an adult of the same species" ;
rdfs:comment "An experimental condition in which a test subject is placed in social contact with an adult (an organism that is fully developed and has reached physical and/or sexual maturity) from the same species." ;
rdfs:subClassOf obo:XCO_0000491 .
obo:XCO_0001082 a rdfs:Class ;
rdfs:label "bovine type II collagen" ;
rdfs:comment "This is any condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye. Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility." ;
rdfs:subClassOf obo:XCO_0000281 .
obo:XCO_0001669 a rdfs:Class ;
rdfs:label "drug withdrawal via context exposure in a Skinner box" ;
rdfs:comment "This is any condition in which the main influencing factor is drug withdrawal via context exposure in a Skinner box lacking levers, cues, and rewards. This withdrawal paradigm uses context exposure (stimuli that were continuously present while learning drug use with operant conditioning)." .
obo:XCO_0000156 a rdfs:Class ;
rdfs:label "0.9% sodium chloride solution" ;
rdfs:comment "This is any condition in which the main influencing factor is a solution of sodium chloride (NaCl) and water in which the level of NaCl is maintained at a mass concentration of 9 grams per liter (0.9 grams per 100 mls of solution, or 0.9 % m/v). The osmolarity of normal saline is a close approximation to the osmolarity of NaCl in blood." ;
rdfs:subClassOf obo:XCO_0000155 .
obo:XCO_0000041 a rdfs:Class ;
rdfs:label "radon exposure" ;
rdfs:comment "The condition of being subjected to transmitted energy from the gaseous radioactive element radon, atomic number 86, resulting from decay of radium. Such radiation is composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule. alpha, beta, and gamma rays are released during the radioactive decay of radon." ;
rdfs:subClassOf obo:XCO_0000039 .
obo:XCO_0001079 a rdfs:Class ;
rdfs:label "adenine" ;
rdfs:comment "This is any condition in which the main influencing factor is adenine, the parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6. Adenine is one of the five constituent bases of nucleic acids.The shape of adenine is complementary to either thymine in DNA or uracil in RNA." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001823 a rdfs:Class ;
rdfs:label "controlled fish oil content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a solid diet in which the amount of fish oil is maintained at a specified level. Fish oil is obtained from the tissues of oily fish and contains the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)." ;
rdfs:subClassOf obo:XCO_0000454 .
obo:XCO_0001493 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to 17alpha-ethynylestradiol" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to 17alpha-ethynylestradiol that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) 17alpha-ethynylestradiol use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001492 .
obo:XCO_0000769 a rdfs:Class ;
rdfs:label "antiserum" ;
rdfs:comment "Blood serum that contains antibodies against an infective agent (such as a bacteria or virus) or toxic substance (such as snake venom) and may be used to prevent or treat infection or poisoning." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0000685 a rdfs:Class ;
rdfs:label "fat emulsion" ;
rdfs:comment "A liquid composed of two immiscible substances, typically some form of fat and water. In parenteral nutrition, a fat emulsion may contain phospholipids, triglycerides and essential fatty acids." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001636 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to corn oil" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to corn oil that has multigenerational effects. This is a condition typically studied to determine the effect of maternal corn oil use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000101 , obo:XCO_0000829 .
obo:XCO_0000261 a rdfs:Class ;
rdfs:label "arthritis inducing chemical" ;
rdfs:comment "A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones." ;
rdfs:subClassOf obo:XCO_0000259 , obo:XCO_0000349 .
obo:XCO_0000782 a rdfs:Class ;
rdfs:label "negatively charged liposomes" ;
rdfs:comment "An experimental condition in which the main influencing factor is negatively charged liposomes, artificial negatively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances." ;
rdfs:subClassOf obo:XCO_0000780 .
obo:XCO_0000652 a rdfs:Class ;
rdfs:label "controlled E4177 content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of E4177 consumed by an organism as part of an experiment. E4177 is an agent that blocks one or more angiotensin II receptors." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001446 a rdfs:Class ;
rdfs:label "CRX527-primed human BM-MSC exosomes" ;
rdfs:comment "This is any condition in which the main influencing factor is exosomes from human, bone marrow-derived, mesenchymal stromal cells which have been primed with the synthetic lipid A analog CRX-527. CRX-527 is a Toll-like receptor 4 (TLR4) agonist." ;
rdfs:subClassOf obo:XCO_0001369 .
obo:XCO_0000255 a rdfs:Class ;
rdfs:label "anti-glomerular basement membrane antibody" ;
rdfs:comment "An immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with one or more components of the structure located between endothelial cells of renal capillaries and the visceral epithelial cells of the kidney glomerulus." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0001808 a rdfs:Class ;
rdfs:label "facial nerve compression" ;
rdfs:comment "This is any condition in which the main influencing factor is compression of the facial nerve induced by an experimental surgical procedure involving clamping of the nerve using forceps." ;
rdfs:subClassOf obo:XCO_0001814 .
obo:XCO_0000027 a rdfs:Class ;
rdfs:label "surgical implantation" ;
rdfs:comment "Any insertion of a tissue, material or device into the body using a procedure involving incision into the body." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000950 a rdfs:Class ;
rdfs:label "anticonvulsant" ;
rdfs:comment "This is any condition in which the main influencing factor is a drug or agent used to prevent seizures or reduce their severity. Anticonvulsants suppress the excessive rapid firing of neurons during seizures and prevent the spread of the seizure within the brain." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0001113 a rdfs:Class ;
rdfs:label "folic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is folic acid, an N-acyl-amino acid that is a form of the water-soluble vitamin B9." ;
rdfs:subClassOf obo:XCO_0000119 , obo:XCO_0000377 .
obo:XCO_0000202 a rdfs:Class ;
rdfs:label "unilateral orchiectomy" ;
rdfs:comment "Surgical removal of a single testis." ;
rdfs:subClassOf obo:XCO_0000201 .
obo:XCO_0000074 a rdfs:Class ;
rdfs:label "controlled caffeine content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of caffeine consumed by an organism as part of an experiment. Caffeine is a xanthine alkaloid that acts primarily as a central nervous system and metabolic stimulant, and also as a mild vasoconstrictor, diuretic, and bronchodilator." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001676 a rdfs:Class ;
rdfs:label "verteporfin" ;
rdfs:comment "This is any condition in which the main influencing factor is verteporfin, a benzoporphyrin derivative used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration." ;
rdfs:subClassOf obo:XCO_0000850 .
obo:XCO_0001407 a rdfs:Class ;
rdfs:label "dextran sulfate sodium" ;
rdfs:comment "This is any condition in which the main influencing factor is dextran sulfate sodium, a synthetic sulfated polysaccharide with anticoagulant activity used in immunological research to induce colitis. Dextran polymer molecules with a molecular weight of 36-50 kDa are frequently used to produce colitis in rodents." ;
rdfs:subClassOf obo:XCO_0001090 .
obo:XCO_0001219 a rdfs:Class ;
rdfs:label "medium-chain triglyceride-containing ketogenic diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight. MCTKDs with different ketogenic ratios are designated by KR values. Medium chain triglycerides are absorbed and transported more efficiently than other types of fat in the diet and yield more ketones produced in the liver per unit of dietary energy." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001508 a rdfs:Class ;
rdfs:label "lead pellet implantation in muscle" ;
rdfs:comment "This is any condition in which the main influencing factor is the surgical implantation of lead pellet(s) in muscle. Lead is a soft, malleable, dense post-transition metal that has been used in many different man-made products." ;
rdfs:subClassOf obo:XCO_0001504 .
obo:XCO_0000904 a rdfs:Class ;
rdfs:label "controlled resveratrol content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of resveratrol in which the amount of resveratrol consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001250 a rdfs:Class ;
rdfs:label "Poria cocos" ;
rdfs:comment "This is any condition in which the main influencing factor is Poria cocos, a fungus used extensively as a medicinal mushroom in traditional Chinese medicine." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000724 a rdfs:Class ;
rdfs:label "Carbon-14 butanol" ;
rdfs:comment "A primary alcohol that is butanol in which one or several of the carbon (C12) atoms is replaced by radioactive Carbon-14." ;
rdfs:subClassOf obo:XCO_0000171 , obo:XCO_0000723 .
obo:XCO_0001745 a rdfs:Class ;
rdfs:label "gene transfer of the P.gingivalis fimA gene and HA2 protein domain using the plasmid vector pVAX1" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of the P.gingivalis fimA gene and HA2 protein domain using the plasmid vector pVAX1. The pVAX1 plasmid was designed for use in the development of DNA vaccines. The FimA gene and the HA2 domain are virulence factors that cooperate during bacterial infection by promoting adhesion and providing nutrients for colonization." ;
rdfs:subClassOf obo:XCO_0001742 .
obo:XCO_0001102 a rdfs:Class ;
rdfs:label "serotonin hydrochloride" ;
rdfs:comment "This is any condition in which the main influencing factor is serotonin hydrochloride, the hydrochloride form of a primary amino compound (serotonin) that is the 5-hydroxy derivative of tryptamine." ;
rdfs:subClassOf obo:XCO_0000144 .
obo:XCO_0000337 a rdfs:Class ;
rdfs:label "air-jet exposure" ;
rdfs:comment "A condition in which an air jet, i.e. a rapid stream of air (the colorless, odorless, tasteless mixture of gases, mainly nitrogen, oxygen and lesser gases, plus water vapor and particulates, that surrounds the earth) forced under pressure through a small opening or nozzle, is directed toward the body or a part of the body of an organism." ;
rdfs:subClassOf obo:XCO_0000052 .
obo:XCO_0000919 a rdfs:Class ;
rdfs:label "N-nitroso-N-methyl-4-aminobutyric acid" ;
rdfs:comment "A nitrosamine that has methyl and 3-carboxypropyl substituents. It is a tobacco-derived nitrosamino acid that is a known animal and potential human carcinogen. It induces bladder transitional cell carcinomas in rats and has recently been identified as a contaminant in certain blood pressure medications." ;
rdfs:subClassOf obo:XCO_0000089 .
obo:XCO_0001807 a rdfs:Class ;
rdfs:label "MgPA hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of MgPA hydrogel, a plant-derived phosphate coordination compound-based adhesive hydrogel that integrates magnesium ions (Mg2+)−phytic acid (PA) nanoparticles with aminated gelatin (Gel-NH2) and aldehydated starch (AS). This hydrogel can firmly adhere to irregular bone surfaces at a fracture site and degrades in the acidic osteoporotic microenvironment, releasing PA and Mg2+ to modulate osteoclast and osteoblast activity." ;
rdfs:subClassOf obo:XCO_0001439 .
obo:XCO_0001519 a rdfs:Class ;
rdfs:label "gestational maternal exposure to a controlled protein content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is gestational maternal exposure to a controlled protein content diet. This is a condition typically studied to determine the effect of a maternal (F0) controlled protein content diet on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001518 .
obo:XCO_0001093 a rdfs:Class ;
rdfs:label "epigallocatechin-3-gallate" ;
rdfs:comment "This is any condition in which the main influencing factor is epigallocatechin-3-gallate, a gallate ester which is an antimutagen found in tea (Camellia sinensis) with the highest concentration in green tea." ;
rdfs:subClassOf obo:XCO_0000435 .
obo:XCO_0000395 a rdfs:Class ;
rdfs:label "controlled 4-nitroquinoline N-oxide content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000266 a rdfs:Class ;
rdfs:label "Freund's complete adjuvant" ;
rdfs:comment "A water-in-oil emulsion incorporating antigen in the aqueous phase, and killed, dried mycobacteria, e.g., Mycobacterium butyricum in lightweight paraffin oil. A suspension is achieved with the aid of an emulsifying agent. The mixture induces both cell-mediated immunity (delayed hypersensitivity), and humoral antibody formation." ;
rdfs:subClassOf obo:XCO_0000264 .
obo:XCO_0001042 a rdfs:Class ;
rdfs:label "T9 spinal cord contusion" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy of the ninth thoracic vertebra and delivery of a controlled contusion of the spinal cord by a mechanical apparatus." ;
rdfs:subClassOf obo:XCO_0001041 .
obo:XCO_0001801 a rdfs:Class ;
rdfs:label "cold atmospheric plasma" ;
rdfs:comment "This is any condition in which the main influencing factor is cold atmospheric plasma, an ionized gas generated when a high-energy electric field is applied to an inert gas, nitrogen, or air. The reactive oxygen and nitrogen species generated activate inflammatory and antioxidant responses." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000482 , obo:XCO_0000850 .
obo:XCO_0001176 a rdfs:Class ;
rdfs:label "LY2886721" ;
rdfs:comment "This is any condition whose main influencing factor is LY2886721, an inhibitor of protease beta-secretase 1 (BACE1), which is a key protease controlling the formation of amyloid β (a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease)." ;
rdfs:subClassOf obo:XCO_0000748 .
obo:XCO_0001707 a rdfs:Class ;
rdfs:label "enolase 2" ;
rdfs:comment "This is any condition in which the main influencing factor is enolase 2 (ENO2), an enolase isoenzyme, found in neurons and cells of neuronal origin. ENO2 is an enzyme with phosphopyruvate hydratase activity involved in gluconeogenesis." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000770 a rdfs:Class ;
rdfs:label "rat anti-Ab2 antiserum" ;
rdfs:comment "Any condition in which the main influencing factor is serum prepared from rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies." ;
rdfs:subClassOf obo:XCO_0000769 .
obo:XCO_0000421 a rdfs:Class ;
rdfs:label "in utero condition" ;
rdfs:comment "Any condition which occurs while an organism is still within the uterus of its mother during the gestation period." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000873 a rdfs:Class ;
rdfs:label "DHD/K12/TRb - Sp-5 cells" ;
rdfs:comment "A condition in which the main influencing factor is the pulmonary metastatic subclone Sp-5 of a rat colonic carcinoma cell line (DHD/K12/TRb) used to study biochemical correlates of metastasis." ;
rdfs:subClassOf obo:XCO_0000710 .
obo:XCO_0000478 a rdfs:Class ;
rdfs:label "Streptococcus pneumoniae TIGR4" ;
rdfs:comment "This is any condition in which the main influencing factor is Streptococcus pneumoniae TIGR4, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers." ;
rdfs:subClassOf obo:XCO_0000476 .
obo:XCO_0001704 a rdfs:Class ;
rdfs:label "stress induced phosphoprotein 1" ;
rdfs:comment "This is any condition in which the main influencing factor is stress induced phosphoprotein 1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding by assisting in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000348 a rdfs:Class ;
rdfs:label "middle cerebral artery occlusion" ;
rdfs:comment "A surgical manipulation causing blockage of the middle cerebral artery (MCA), one of the three major paired arteries that supply blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it branches and projects into the lateral cerebral cortex." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0000551 a rdfs:Class ;
rdfs:label "hydralazine" ;
rdfs:comment "An experimental condition in which the main influencing factor is hydralazine, a vasodilator that appears to have multiple, direct effects on smooth muscles of the arterial vessels, thereby reducing systemic vascular resistance and arterial pressure." ;
rdfs:subClassOf obo:XCO_0000140 .
obo:XCO_0000288 a rdfs:Class ;
rdfs:label "R16 peptide of interphotoreceptor retinoid-binding protein" ;
rdfs:comment "A condition in which the major influencing factor is a 15 amino acid peptide (aa 1177-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors." .
obo:XCO_0000866 a rdfs:Class ;
rdfs:label "anal sphincter myotomy" ;
rdfs:comment "Any process involving manual and instrumental techniques for incision of the internal anal sphincter muscle. The inner is controlled by the nervous system, while the external anal sphincter muscle is under voluntary control." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000899 a rdfs:Class ;
rdfs:label "hydrochlorothiazide" ;
rdfs:comment "This is a thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism." ;
rdfs:subClassOf obo:XCO_0000122 .
obo:XCO_0000940 a rdfs:Class ;
rdfs:label "controlled ex vivo pancreas condition" ;
rdfs:comment "This is an experimental condition in which the internal or external environment of a pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." ;
rdfs:subClassOf obo:XCO_0000464 .
obo:XCO_0000489 a rdfs:Class ;
rdfs:label "temporary social environment condition" ;
rdfs:comment "Any condition in which the social environment of an organism is set or changed for a specified and/or limited period of time." ;
rdfs:subClassOf obo:XCO_0000488 .
obo:XCO_0000787 a rdfs:Class ;
rdfs:label "sodium butyrate" ;
rdfs:comment "Any condition in which the main influencing factor is sodium butyrate, an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid (a short-chain fatty acid) by a sodium ion." ;
rdfs:subClassOf obo:XCO_0000776 .
obo:XCO_0000635 a rdfs:Class ;
rdfs:label "polyfructosan" ;
rdfs:comment "A naturally occurring sugar polymer that acts as an energy storage molecule in plants. It is an inulin analogue and highly soluble in water ." ;
rdfs:subClassOf obo:XCO_0000174 .
obo:XCO_0000454 a rdfs:Class ;
rdfs:label "controlled oil content diet" ;
rdfs:comment "A solid diet in which the amount of a specified oil is maintained at a specified level. An oil is any unctuous, combustible substance that is liquid, or easily liquefiable, on warming, and is soluble in ether but not in water. Oils may be animal, vegetable, or mineral in origin." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001715 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to lactate dehydrogenase A MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to an autoantibody-generating level of lactate dehydrogenase A (LDHA) multiple antigenic peptides (MAPs). This is a condition typically studied to determine the effect of maternal (F0) LDHA exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001714 .
obo:XCO_0001072 a rdfs:Class ;
rdfs:label "gene transfer of the sTGFβR2 gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the soluble transforming growth factor-beta receptor 2 gene (sTGFβR2) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000050 a rdfs:Class ;
rdfs:label "olfactory stimulus" ;
rdfs:comment "Any action or condition designed to cause the registration or perception of a stimulus, by organs or receptors involved in the sense of smell. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." ;
rdfs:subClassOf obo:XCO_0000047 .
obo:XCO_0001208 a rdfs:Class ;
rdfs:label "MWNT-7" ;
rdfs:comment "This is any condition in which the main influencing factor is MWNT-7, a multi‐walled carbon nanotube, which is a molecule consisting of three or more concentric graphene cylinders. Fibers of MWNT-7 range in size from 5.11 μm to 84.7 nm." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000342 .
obo:XCO_0001611 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to standard rat chow diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to a standard rat chow diet. This is a condition typically studied to determine the effect of a maternal (F0) standard rat chow diet on the F1 offspring." .
obo:XCO_0000294 a rdfs:Class ;
rdfs:label "estrogen/estrogen analog" ;
rdfs:comment "Any of the naturally-occuring, primary female sex hormones or related synthetic molecules with the capacity to perform the same function(s), i.e. to bind to estrogen receptors and stimulate or control the development and maintenance of female sex characteristics." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0000966 a rdfs:Class ;
rdfs:label "controlled serum-free condition" ;
rdfs:comment "This is any experimental condition in which cultured cells are grown in a defined medium without added animal serum." ;
rdfs:subClassOf obo:XCO_0000965 .
obo:XCO_0000854 a rdfs:Class ;
rdfs:label "rat serum from subject bearing IR983F myeloma" ;
rdfs:comment "Any condition in which the main influencing factor is serum prepared from rats bearing subcutaneously injected IR983F myeloma cells. The serum is essentially control for antiserum from rats bearing IgE-producing hybridomas." ;
rdfs:subClassOf obo:XCO_0000769 .
obo:XCO_0000573 a rdfs:Class ;
rdfs:label "null" .
obo:XCO_0001834 a rdfs:Class ;
rdfs:label "SKF-81297" ;
rdfs:comment "This is any condition in which the main influencing factor is SKF-81297, a dopamine D1-like receptor agonist." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000502 a rdfs:Class ;
rdfs:label "body part position change" ;
rdfs:comment "A condition characterized by an alteration in the placement, arrangement or orientation of any part of the body of an organism such as an organ or extremity." ;
rdfs:subClassOf obo:XCO_0000066 .
obo:XCO_0001457 a rdfs:Class ;
rdfs:label "ketanserin" ;
rdfs:comment "This is any condition in which the main influencing factor is ketanserin, a selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. Ketanserin is effective in lowering blood pressure in essential hypertension and it also inhibits platelet aggregation." ;
rdfs:subClassOf obo:XCO_0000336 , obo:XCO_0000863 .
obo:XCO_0000871 a rdfs:Class ;
rdfs:label "5-fluorouracil" ;
rdfs:comment "A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. Following conversion to the active deoxynucleotide, It inhibits DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000636 .
obo:XCO_0000888 a rdfs:Class ;
rdfs:label "pilocarpine" ;
rdfs:comment "Pilocarpine is a miotic alkaloid obtained from jaborandi that is used chiefly in the form of its hydrochloride or nitrate especially in the treatment of glaucoma. It is a cholinergic (muscarinic) agonist and used to cause seizures in animal models of epilepsy." ;
rdfs:subClassOf obo:XCO_0000693 , obo:XCO_0000886 .
obo:XCO_0001061 a rdfs:Class ;
rdfs:label "oligosaccharide" ;
rdfs:comment "This is any condition in which the main influencing factor is an oligosaccharide, a compound in which a small number of monosaccharide units (2-10) are joined by alpha- or beta-glycosidic linkages." ;
rdfs:subClassOf obo:XCO_0000172 .
obo:XCO_0000828 a rdfs:Class ;
rdfs:label "human myelin basic protein" ;
rdfs:comment "Any condition in which the main influencing factor is human myelin basic protein, a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Human myelin basic protein is purified from human tissue or extracted from cultured cells containing cloned copies of the human myelin basic protein gene." ;
rdfs:subClassOf obo:XCO_0000688 .
obo:XCO_0000566 a rdfs:Class ;
rdfs:label "controlled ipragliflozin content diet" ;
rdfs:comment "A solid diet in which the amount of ipragliflozin, an oral antidiabetic drug, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000565 .
obo:XCO_0000283 a rdfs:Class ;
rdfs:label "visible light stimulus" ;
rdfs:comment "Exposure to visible light in a manner, such as for a length of time or at a level, which would not be considered natural, usual or environmental and which is designed to elicit or evoke an action or response in a cell, an excitable tissue, or an organism." ;
rdfs:subClassOf obo:XCO_0000049 , obo:XCO_0000284 .
obo:XCO_0001053 a rdfs:Class ;
rdfs:label "surgical closure" ;
rdfs:comment "This is any condition in which the main influencing factor is closure of a wound, body parts, or anatomical orifices by the use of sutures, staples, or surgical adhesive/sealant." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000847 a rdfs:Class ;
rdfs:label "Hu-S110-129" ;
rdfs:comment "Any condition in which the main influencing factor is a 20 amino acid polypeptide representing residues 110 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon." ;
rdfs:subClassOf obo:XCO_0000828 .
obo:XCO_0000411 a rdfs:Class ;
rdfs:label "reproduction condition" ;
rdfs:comment "Any experimental condition that is specifically related to the reproduction of the organism, that is, to the cellular, genetic, behavioral and temporal processes by which an organism produces offspring similar to itself so that the species is perpetuated." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000016 a rdfs:Class ;
rdfs:label "standard rat chow" ;
rdfs:comment "This is any condition in which the main influencing factor is standard rat chow, a laboratory foodstuff which typically has 380-390 kcal/100 g with 9-10% of calories derived from fat, 70-80% of calories derived from carbohydrate, and 10-15% of calories derived from protein." ;
rdfs:subClassOf obo:XCO_0000069 .
obo:XCO_0000792 a rdfs:Class ;
rdfs:label "emodin" ;
rdfs:comment "A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000435 .
obo:XCO_0000970 a rdfs:Class ;
rdfs:label "protein kinase inhibitor" ;
rdfs:comment "This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a protein kinase inhibitor. A protein kinase is an enzyme that regulates the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001546 a rdfs:Class ;
rdfs:label "tramadol hydrochloride" ;
rdfs:comment "This is any condition in which the main influencing factor is tramadol hydrochloride, a racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol hydrochloride. Tramadol hydrochloride is a centrally acting synthetic opioid analgesic, used to treat moderately severe pain. Tramadol hydrochloride has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, a serotonergic antagonist and a serotonin uptake inhibitor." ;
rdfs:subClassOf obo:XCO_0000336 , obo:XCO_0000947 , obo:XCO_0001329 .
obo:XCO_0001282 a rdfs:Class ;
rdfs:label "sodium carboxymethylcellulose" ;
rdfs:comment "This is any condition in which the main influencing factor is sodium carboxymethylcellulose, a cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. Sodium carboxymethylcellulose is a commonly used form of carboxymethylcellulose." ;
rdfs:subClassOf obo:XCO_0001129 .
obo:XCO_0001783 a rdfs:Class ;
rdfs:label "streptomycin sulfate" ;
rdfs:comment "This is any condition in which the main influencing factor is streptomycin sulfate, the sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus. Streptomycin sulfate is used medically for severe infections and in labs to prevent bacterial contamination in cell cultures by inhibiting bacterial protein synthesis. Side effects include dizziness, hearing issues (ototoxicity), and kidney toxicity." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0001112 .
obo:XCO_0000630 a rdfs:Class ;
rdfs:label "cholinergic antagonist" ;
rdfs:comment "Agents that bind to cholinoceptors (muscarinic or nicotinic) and prevent the effects of acetylcholine (ACh) and other cholinergic agonists." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000658 a rdfs:Class ;
rdfs:label "nisoldipine" ;
rdfs:comment "A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000269 .
obo:XCO_0001384 a rdfs:Class ;
rdfs:label "gestational maternal exposure to lipopolysaccharide" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to lipopolysaccharide. This is a condition typically studied to determine the effect of maternal (F0) lipopolysaccharide use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001383 .
obo:XCO_0001726 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to Freund's adjuvant and saline" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to a mix of Freund's adjuvant and saline that serves as vehicle control for antibody-generating conditions that have multigenerational effects. These are conditions typically studied to determine the effect of a maternal (F0) exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000101 .
obo:XCO_0001192 a rdfs:Class ;
rdfs:label "nadolol" ;
rdfs:comment "This is any condition in which the main influencing factor is nadolol, a non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used to treat vascular headaches." ;
rdfs:subClassOf obo:XCO_0000336 , obo:XCO_0000863 .
obo:XCO_0000319 a rdfs:Class ;
rdfs:label "artificial aortocaval fistula" ;
rdfs:comment "A surgically created passageway between the abdominal aorta and inferior vena cava." ;
rdfs:subClassOf obo:XCO_0000595 .
obo:XCO_0000233 a rdfs:Class ;
rdfs:label "ribonucleic acid" ;
rdfs:comment "A long, polymeric chain of alternating phosphate and ribose units with the bases adenine, guanine, cytosine, and uracil bonded to the ribose. Although RNA is usually single-stranded it can also exist as RNA:RNA or RNA:DNA double-stranded molecules." ;
rdfs:subClassOf obo:XCO_0000232 .
obo:XCO_0000727 a rdfs:Class ;
rdfs:label "splenectomy" ;
rdfs:comment "Surgical removal of part or all of the spleen, the highly vascular lymphoid organ which serves to store blood, disintegrate old blood cells, filter foreign substances from the blood, and produce lymphocytes." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000153 a rdfs:Class ;
rdfs:label "sample resting period" ;
rdfs:comment "A predetermined and specified amount of time during which an experimental specimen sits undisturbed, for example to allow a chemical reaction to proceed." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000460 a rdfs:Class ;
rdfs:label "subcutaneous interscapular air pouch" ;
rdfs:comment "Induction and/or maintenance of a hollow cavity beneath the skin between the scapulae (the flat triangular bones at the top or back of the shoulder), by injection or other introduction of a specified volume of air. Experimental air pouches are often used to encapsulate foreign cells or other substances." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000608 a rdfs:Class ;
rdfs:label "Allyl isothiocyanate" ;
rdfs:comment "An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000482 .
obo:XCO_0000474 a rdfs:Class ;
rdfs:label "alendronate" ;
rdfs:comment "Condition in which the main influencing factor is alendronate (the anionic form of alendronic acid), a bisphosphonate drug used for osteoporosis and several other bone diseases, because it inhibits osteoclast-mediated bone-resorption." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0001299 a rdfs:Class ;
rdfs:label "middle cerebral artery occlusion sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a middle cerebral artery (MCA) occlusion sham procedure, which follows the same surgical process as an MCA occlusion without blocking the middle cerebral artery." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000096 a rdfs:Class ;
rdfs:label "unilateral ovariectomy" ;
rdfs:comment "Surgical removal of a single ovary." ;
rdfs:subClassOf obo:XCO_0000094 .
obo:XCO_0000915 a rdfs:Class ;
rdfs:label "controlled ethanol content drinking water used as vehicle" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of ethanol, serving as a control condition for some chemical delivered in ethanol and drinking water." ;
rdfs:subClassOf obo:XCO_0000023 .
obo:XCO_0000930 a rdfs:Class ;
rdfs:label "renal denervation" ;
rdfs:comment "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol." ;
rdfs:subClassOf obo:XCO_0000373 .
obo:XCO_0000496 a rdfs:Class ;
rdfs:label "neurotoxin" ;
rdfs:comment "A condition in which the main influencing factor is a peptide, a protein or a conjugated protein produced by some higher plants, animals, and pathogenic bacteria, that is poisonous or destructive to nerve cells or tissue." ;
rdfs:subClassOf obo:XCO_0000240 , obo:XCO_0000495 .
obo:XCO_0000167 a rdfs:Class ;
rdfs:label "controlled in situ kidney condition" ;
rdfs:comment "Any experimental condition in which the internal or external environment of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." ;
rdfs:subClassOf obo:XCO_0000166 .
obo:XCO_0001015 a rdfs:Class ;
rdfs:label "myectomy" ;
rdfs:comment "This is any condition in which the main influencing factor is creating a volumetric muscle loss (VML) of 20% or more of the total amount of mass in the targeted muscle through surgical removal (myectomy)." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000818 a rdfs:Class ;
rdfs:label "gene transfer using a plasmid vector" ;
rdfs:comment "A condition in which gene transfer has been performed using a plasmid as the carrier of the genetic material. A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell's chromosomal DNA. Plasmids naturally exist in bacterial cells, and they also occur in some eukaryotes. Plasmids that are used experimentally as molecular tools are called vectors." ;
rdfs:subClassOf obo:XCO_0000528 .
obo:XCO_0000009 a rdfs:Class ;
rdfs:label "controlled air content" ;
rdfs:comment "This is any condition in which the main influencing factor is control of the amount of one or more of the gases or particles which make up or are found in the air surrounding an organism during the time course of some biological measurement." ;
rdfs:subClassOf obo:XCO_0000998 .
obo:XCO_0001068 a rdfs:Class ;
rdfs:label "sleep" ;
rdfs:comment "This is any condition in which the main influencing factor is sleep, the natural, easily reversible periodic state of many living things that is marked by the absence of wakefulness and by the loss of consciousness of one's surroundings, is accompanied by a typical body posture (such as lying down with the eyes closed), the occurrence of dreaming, and changes in brain activity and physiological functioning." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000678 a rdfs:Class ;
rdfs:label "gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the transfer (transiently or stably) of the rat MER proto-oncogene, tyrosine kinase gene into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000404 a rdfs:Class ;
rdfs:label "controlled bisphenol A content diet" ;
rdfs:comment "A solid diet in which the amount of bisphenol A is maintained at a specified level. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001028 a rdfs:Class ;
rdfs:label "gene transfer of the EYFP gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the enhanced yellow fluorescent protein (EYFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EYFP in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0000669 a rdfs:Class ;
rdfs:label "diazoxide" ;
rdfs:comment "Any condition in which the main influencing factor is diazoxide, a benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000618 .
obo:XCO_0000011 a rdfs:Class ;
rdfs:label "air temperature" ;
rdfs:comment "The degree of heat or cold of the air surrounding an organism." ;
rdfs:subClassOf obo:XCO_0000111 .
obo:XCO_0001766 a rdfs:Class ;
rdfs:label "fentanyl hydrochloride" ;
rdfs:comment "This is any condition in which the main influencing factor is fentanyl hydrochloride, the hydrochloride salt form of fentanyl. Fentanyl is a potent, synthetic opioid analgesic/anesthetic and primarily a mu-opioid agonist." ;
rdfs:subClassOf obo:XCO_0001754 .
obo:XCO_0001819 a rdfs:Class ;
rdfs:label "DNA transfer using a plasmid vector" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of DNA via a plasmid into a living cell or organism. A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell's chromosomal DNA. Plasmids are both naturally occurring and artificially used as molecular tools for experimentation and clinical manipulations." ;
rdfs:subClassOf obo:XCO_0001818 .
obo:XCO_0001418 a rdfs:Class ;
rdfs:label "transgenerational paternal exposure to folic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is any paternal exposure to folic acid that has transgenerational effects. This is a condition typically studied to determine the effect of paternal (F0) folic acid use/exposure on the F2/F3 offspring by direct effects on the F1 generation via germ cell exposure. The paternal exposure may be any time after sexual maturity up to the time of copulation." ;
rdfs:subClassOf obo:XCO_0001113 .
obo:XCO_0000308 a rdfs:Class ;
rdfs:label "heat exposure" ;
rdfs:comment "An activity or condition which involves subjecting all or part of an organism to a relatively high, or higher than considered normal, temperature, that is, possessing a higher than normal level of random kinetic energy of atoms, molecules, or ions." ;
rdfs:subClassOf obo:XCO_0000111 .
obo:XCO_0000359 a rdfs:Class ;
rdfs:label "sodium p-aminohippurate" ;
rdfs:comment "A condition in which the main influencing factor is an organic sodium salt that is the monosodium salt of p-aminohippuric acid, an amide derivative of the amino acid glycine and para-aminobenzoic acid. Sodium p-aminohippurate is used as a diagnostic agent in the measurement of renal plasma flow." ;
rdfs:subClassOf obo:XCO_0000358 .
obo:XCO_0000575 a rdfs:Class ;
rdfs:label "meropenem" ;
rdfs:comment "Meropenem is a broad-spectrum antibiotic used to treat a variety of bacterial infections." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0001827 a rdfs:Class ;
rdfs:label "revision of orthopedic implant" ;
rdfs:comment "This is any condition in which the main influencing factor is a surgical procedure in which a previously placed orthopedic implant is removed and/or replaced. Orthopedic implants are medical devices intended either to replace a missing bone or joint, or to support a damaged bone." ;
rdfs:subClassOf obo:XCO_0001826 .
obo:XCO_0001238 a rdfs:Class ;
rdfs:label "ticlopidine" ;
rdfs:comment "This is any condition in which the main influencing factor is ticlopidine, an inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0001090 .
obo:XCO_0000986 a rdfs:Class ;
rdfs:label "transfer of the rat wild type Ccny-specific shRNA and EGFP gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y while inducing EGFP synthesis in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000983 , obo:XCO_0000985 .
obo:XCO_0000010 a rdfs:Class ;
rdfs:label "controlled air oxygen content" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled air oxygen content surrounding an organism or breathed by the organism as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0001370 a rdfs:Class ;
rdfs:label "Ancr/E7-exosomes" ;
rdfs:comment "This is any condition in which the main influencing factor is Ancr/E7-modified exosomes, which are exosomes generated from Lamp2b-E7 transfected host cells, collected, and electroporated with lncRNA-ANCR. The experimental purpose of delivery of Ancr/E7-exosomes is blood vessel anticalcification." ;
rdfs:subClassOf obo:XCO_0001369 .
obo:XCO_0000326 a rdfs:Class ;
rdfs:label "controlled ethanol content saline" ;
rdfs:comment "Any condition in which the main influencing factor is ethanol, the colorless, volatile, flammable liquid, CH3CH2OH, produced by yeast fermentation of carbohydrates or synthesized by hydration of ethylene, suspended in a saline solution, a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of water." ;
rdfs:subClassOf obo:XCO_0000156 .
obo:XCO_0000503 a rdfs:Class ;
rdfs:label "head position change" ;
rdfs:comment "A condition characterized by an alteration in the placement, arrangement or orientation of the head of an organism." ;
rdfs:subClassOf obo:XCO_0000502 .
obo:XCO_0000791 a rdfs:Class ;
rdfs:label "obsolete standard condition" ;
rdfs:comment "OBSOLETE. A condition defined by a mostly uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison." .
obo:XCO_0000648 a rdfs:Class ;
rdfs:label "clodronic acid" ;
rdfs:comment "An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases." ;
rdfs:subClassOf obo:XCO_0000435 .
obo:XCO_0000465 a rdfs:Class ;
rdfs:label "controlled ex vivo artery condition" ;
rdfs:comment "Any experimental condition in which the internal or external environment of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." ;
rdfs:subClassOf obo:XCO_0000464 .
obo:XCO_0000246 a rdfs:Class ;
rdfs:label "controlled cholesterol content diet" ;
rdfs:comment "A regimen of solid food in which the amount of cholesterol, a steroid alcohol found in animal fats and oils, is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000482 a rdfs:Class ;
rdfs:label "antimicrobial agent" ;
rdfs:comment "A substance that kills or slows the growth of one or more microorganisms, including bacteria, viruses, fungi and protozoans." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0001439 a rdfs:Class ;
rdfs:label "bone tissue engineering scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of an engineered bone tissue scaffold, an artificial construct which mimics the extracellular matrix of the host tissue. Support of the attachment and proliferation of osteoblasts, formation of mineralized bone matrix, and osteodifferentiation of endogenous mesenchymal stem cells (MSCs) are some desired characteristics of these implants. Both synthetic and natural polymers may be a part of bone scaffolds." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0000665 a rdfs:Class ;
rdfs:label "beta-adrenergic agonist" ;
rdfs:comment "A substance that selectively binds to and activates beta-adrenergic receptors." ;
rdfs:subClassOf obo:XCO_0000664 .
obo:XCO_0000284 a rdfs:Class ;
rdfs:label "controlled visible light exposure" ;
rdfs:comment "Condition during which a subject or sample is directly in the presence of or influenced by visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, at a constrained level and/or for a constrained period of time." ;
rdfs:subClassOf obo:XCO_0000045 , obo:XCO_0000181 .
obo:XCO_0001162 a rdfs:Class ;
rdfs:label "flutamide" ;
rdfs:comment "This is any condition in which the main influencing factor is flutamide ,a monocarboxylic acid amide which has a role as an androgen receptor antagonist and an antineoplastic agent." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0000435 .
obo:XCO_0000235 a rdfs:Class ;
rdfs:label "poly I:C" ;
rdfs:comment "This is any condition in which the main influencing factor is poly I:C, a synthetic dsRNA composed of a strand of poly(I) annealed to a strand of poly(C). Poly(I:C) is acts as an immunostimulant and mimics a viral infection by interacting with Toll-like receptor 3 (TLR3)." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0000564 a rdfs:Class ;
rdfs:label "meclofenamate" ;
rdfs:comment "A member of the anthranilic acid derivatives class of NSAID drug used for joint, muscular pain, arthritis and dysmenorrhea." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0001684 a rdfs:Class ;
rdfs:label "empagliflozin" ;
rdfs:comment "This is any condition in which the main influencing factor is empagliflozin, an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporter primarily responsible for the reabsorption of glucose in the kidney. It is used as a hypoglycemic agent for the management of type 2 diabetes mellitus." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000407 .
obo:XCO_0001756 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to fentanyl" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to fentanyl. This is a condition typically studied to determine the effect of maternal (F0) fentanyl use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001755 .
obo:XCO_0000878 a rdfs:Class ;
rdfs:label "Hespan buffer perfusate" ;
rdfs:comment "Any condition in which the main influencing factor is Hespan buffer (6% hetastarch in buffered solution) injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." ;
rdfs:subClassOf obo:XCO_0000115 , obo:XCO_0000877 .
obo:XCO_0000524 a rdfs:Class ;
rdfs:label "angiotensin converting enzyme inhibitor" ;
rdfs:comment "Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of angiotensin converting enzyme (ACE). ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. ACE inhibitors are used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0000863 .
obo:XCO_0001833 a rdfs:Class ;
rdfs:label "brain open puncture" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental surgical procedure involving a penetrating wound occurring in the brain caused by a pointed object." ;
rdfs:subClassOf obo:XCO_0000968 .
obo:XCO_0001381 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to metyrapone" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to metyrapone that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) metyrapone use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001380 .
obo:XCO_0000862 a rdfs:Class ;
rdfs:label "bendroflumethiazide" ;
rdfs:comment "A condition in which the main influencing factor is bendroflumethiazide, a sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders." ;
rdfs:subClassOf obo:XCO_0000863 .
obo:XCO_0001822 a rdfs:Class ;
rdfs:label "BG-11 medium hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is BG-11 medium hydrogel, a cross-linked polymer chain structure containing growth medium used to culture cyanobacteria (blue-green algae) strains of freshwater, soil, or thermal origin. BG-11 medium typically contains nitrogen, phosphate, and trace metals, although strains capable of aerobic nitrogen fixation are maintained in a version lacking nitrogen." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:MESH_D013754 a rdfs:Class .
obo:XCO_0000905 a rdfs:Class ;
rdfs:label "castor oil" ;
rdfs:comment "Any condition in which the main influencing factor is castor oil, a mixture of triglycerides obtained by pressing the seeds of the castor oil plant, Ricinus communis It is used as a cathartic and as a plasticizer." ;
rdfs:subClassOf obo:XCO_0000774 .
obo:XCO_0001275 a rdfs:Class ;
rdfs:label "unpredictable chronic mild stress" ;
rdfs:comment "This is any condition in which the main influencing factor is unpredictable chronic mild stress, an experimental model of depression that involves exposing laboratory animals (usually mice or rats) at unpredictable times over several weeks to a series of minor-intensity stressors. This process results in the development of a number of behavioral alterations in a large majority of animals, including anhedonia (loss of pleasure) and apathy." ;
rdfs:subClassOf obo:XCO_0001265 .
obo:XCO_0001481 a rdfs:Class ;
rdfs:label "ex vivo ischemic liver condition" ;
rdfs:comment "This is any condition in which the main influencing factor is ischemia of an ex vivo liver, a liver that has been removed from an organism, but not oxygenated by perfusion or other means." ;
rdfs:subClassOf obo:XCO_0001478 .
obo:XCO_0000606 a rdfs:Class ;
rdfs:label "AMG-8718" ;
rdfs:comment "AMG-8718 is the inhibitor of β-site amyloid precursor protein cleaving enzyme (BACE1)." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0000416 a rdfs:Class ;
rdfs:label "milk" ;
rdfs:comment "This is any condition in which the main influencing factor is milk, a nutrient fluid containing proteins, fats, lactose, and various vitamins and minerals produced by the mammary gland of a female mammal." ;
rdfs:subClassOf obo:XCO_0000020 .
obo:XCO_0000885 a rdfs:Class ;
rdfs:label "diabetes-inducing chemical" ;
rdfs:comment "A condition in which the main influencing factor is substance that is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling diabetes mellitus through destruction of the beta cells." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0001343 a rdfs:Class ;
rdfs:label "human, skin-derived ABCB5+ MSC/THP-1-conditioned medium" ;
rdfs:comment "This is any condition in which the main influencing factor is a co-culture of human, skin-derived ABCB5+ stromal cells and THP-1-derived macrophage-conditioned medium, which consists of the liquid nutrient medium the cells are grown in plus soluble factors secreted by the cells." ;
rdfs:subClassOf obo:XCO_0001341 .
obo:XCO_0000513 a rdfs:Class ;
rdfs:label "dibutyl phthalate" ;
rdfs:comment "A condition in which the main influencing factor is dibutyl phthalate (DBP), the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. DBP has been used as a plasticizer and as an antiparasitic drug used to treat infestation of parasites on the surface of the body, and is suspected of being an endocrine disruptor and teratogen." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0000512 .
obo:XCO_0000336 a rdfs:Class ;
rdfs:label "adrenergic antagonist" ;
rdfs:comment "This is any condition in which the main influencing factor is an adrenergic antagonist, an agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists, substances that have an affinity for and stimulate physiologic activity at adrenergic receptors. Adrenergic receptors are a class of G protein-coupled receptors that bind catecholamines, especially norepinephrine and epinephrine." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000672 a rdfs:Class ;
rdfs:label "tetracyclines" ;
rdfs:comment "This is any condition in which the main influencing factor is a subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001811 a rdfs:Class ;
rdfs:label "choline‐deficient L‐amino acid‐defined diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a choline‐defficient, L-amino acid‐defined (CDAA) diet, a choline-deficient diet in which proteins are replaced with an equivalent and corresponding mixture of L-amino acids. A CDAA diet is often used in studies investigating the effects of choline deficiency on liver health, particularly in models of non-alcoholic fatty liver disease (NAFLD) or hepatocellular carcinoma." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001547 a rdfs:Class ;
rdfs:label "controlled tramadol hydrochloride content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of tramadol hydrochloride, a synthetic opioid analgesic, consumed by a subject." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001312 a rdfs:Class ;
rdfs:label "controlled Pkc-IN-1 content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a solid diet in which the amount of Pkc-IN-1 is maintained at a specified level. Pkc-IN-1 is a potent, ATP-competitive inhibitor of PKCα and PKCβ." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0001311 .
obo:XCO_0000679 a rdfs:Class ;
rdfs:label "fenofibrate" ;
rdfs:comment "A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring. Used as a lipid -lowering drug." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0000680 .
obo:XCO_0001387 a rdfs:Class ;
rdfs:label "testosterone propionate" ;
rdfs:comment "This is any condition in which the main influencing factor is testosterone propionate, a testosterone ester and a relatively short-acting prodrug of testosterone in the human body. Testosterone propionate is a synthetic androstane steroid derivative of testosterone in the form of 17beta propionate ester of testosterone." .
obo:XCO_0000213 a rdfs:Class ;
rdfs:label "arginine" ;
rdfs:comment "Any condition in which the main influencing factor is arginine (L-arginine), an alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group." ;
rdfs:subClassOf obo:XCO_0000119 .
obo:XCO_0000707 a rdfs:Class ;
rdfs:label "carvedilol" ;
rdfs:comment "Carvedilol is a beta-blocker that works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. It is used to treat heart failure, high blood pressure, and heart attack patients." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000336 .
obo:XCO_0001195 a rdfs:Class ;
rdfs:label "nefazodone" ;
rdfs:comment "This is any condition in which the main influencing factor is nefazodone, an aromatic ether with multiple roles, including that of an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000336 , obo:XCO_0000561 .
obo:XCO_0000690 a rdfs:Class ;
rdfs:label "controlled vitamin content diet" ;
rdfs:comment "A solid diet in which the amount of any vitamin is maintained at a specified level. Vitamins are organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001039 a rdfs:Class ;
rdfs:label "Clodronate-filled liposomes" ;
rdfs:comment "This is any condition in which the main influencing factor is clodronate-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing clodronate." ;
rdfs:subClassOf obo:XCO_0000648 , obo:XCO_0000780 .
obo:XCO_0001809 a rdfs:Class ;
rdfs:label "GQ-16" ;
rdfs:comment "This is any condition in which the main influencing factor is GQ-16, a PPARgamma partial agonist that inhibits Cdk5-mediated Ser-273 phosphorylation. GQ-16 improves insulin sensitivity and glucose tolerance in obese and diabetic mice and exhibits cytotoxicity against tumor cells." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000268 a rdfs:Class ;
rdfs:label "balloon angioplasty" ;
rdfs:comment "A technique of mechanically widening narrowed or obstructed arteries by use of a soft catheter with an inflatable tip." ;
rdfs:subClassOf obo:XCO_0000595 .
obo:XCO_0001720 a rdfs:Class ;
rdfs:label "lactate dehydrogenase B MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is lactate dehydrogenase B (LDHB) presented as multiple antigenic peptides (MAPs), which are four copies of the same peptide epitope synthesized on a lysine-based core (MAPs-4 system)." ;
rdfs:subClassOf obo:XCO_0001716 .
obo:XCO_0000136 a rdfs:Class ;
rdfs:label "enzyme substrate" ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001849 a rdfs:Class ;
rdfs:label "sciatic nerve constriction sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a sciatic nerve constriction sham procedure, which follows the same surgical process as a sciatic nerve constriction without ligating the nerve." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0001470 a rdfs:Class ;
rdfs:label "hmSi-CREKA-RB-PFH nanoparticle" ;
rdfs:comment "This is any condition in which the main influencing factor is hmSi-CREKA-RB-PFH nanoparticles, nanoparticles based on hollow mesoporous silica (hmSi), coated with CREKA (the fibrin-targeting peptide Cys-Arg-Glu-Lys-Ala), and filled with sonosensitizer RB (Rose Bengal) and phase transition molecular PFH (perfluorohexane). These particles are combined with the action of ultrasound in sonodynamic therapy (SDT) of thrombus." ;
rdfs:subClassOf obo:XCO_0000338 .
obo:XCO_0000240 a rdfs:Class ;
rdfs:label "toxin" ;
rdfs:comment "This is any condition in which the main influencing factor is a toxin, a noxious or poisonous substance produced by a biological organism such as a microbe, animal or plant." ;
rdfs:subClassOf obo:XCO_0000239 .
obo:XCO_0000021 a rdfs:Class ;
rdfs:label "water" ;
rdfs:comment "This is any condition in which the main influencing factor is water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Water may be used for drinking, as a solvent, or as an environmental component." ;
rdfs:subClassOf obo:XCO_0000020 , obo:XCO_0000342 , obo:XCO_0001231 .
obo:XCO_0001800 a rdfs:Class ;
rdfs:label "human menstrual blood-derived mesenchymal stem cell spheroids gelatin hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a hydrogel implanted with human menstrual blood-derived mesenchymal stem cells in the form of cell spheres." ;
rdfs:subClassOf obo:XCO_0001799 .
obo:XCO_0000584 a rdfs:Class ;
rdfs:label "obsolete controlled cecal material content oral gavage" ;
rdfs:comment "OBSOLETE. An oral gavage delivery made up of a specified amount of harvested cecal material." .
obo:XCO_0001746 a rdfs:Class ;
rdfs:label "CpG-ODN adjuvant" ;
rdfs:comment "This is any condition in which the main influencing factor is an CpG-CpG oligodeoxynucleotide (ODN) adjuvant. CpG-ODN are short synthetic DNA molecules that mimic microbial DNA by activating Toll-like Receptor 9 (TLR9) and, when paired with a vaccine antigen, lead to increased production of antibodies and enhanced cellular immunity." ;
rdfs:subClassOf obo:XCO_0000133 .
obo:XCO_0000409 a rdfs:Class ;
rdfs:label "controlled metformin content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of metformin consumed by an organism as part of an experiment. Metformin is an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis)." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001398 a rdfs:Class ;
rdfs:label "phenylethanoid glycosides" ;
rdfs:comment "This is any condition in which the main influencing factor is phenylethanoid glycosides (PhGs), a class of natural glycosides containing hydroxy-methoxy-substituted phenylethyl and hydroxy-methoxy-substituted cinnamoyl groups, usually with central glucose as the parent core, and also an ester bond and oxygen glycoside bond. PhGs are obtained from a wide range of sources and show strong biological and pharmacological activities, such as antioxidant, antibacterial and neuroprotective effects." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000483 , obo:XCO_0000850 .
obo:XCO_0001115 a rdfs:Class ;
rdfs:label "(6S)-5-methyltetrahydrofolic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is (6S)-5-methyltetrahydrofolic acid, the primary biologically active form of folate (vitamin B9)." ;
rdfs:subClassOf obo:XCO_0000377 .
obo:XCO_0001173 a rdfs:Class ;
rdfs:label "loracarbef" ;
rdfs:comment "This is any condition in which the main influencing factor is loracarbef, a carbacephem antibiotic used to treat a wide range of infections caused by both gram-positive and gram-negative bacteria." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0000173 a rdfs:Class ;
rdfs:label "polysaccharide" ;
rdfs:comment "This is any condition whose main influencing factor is a polysaccharide, a macromolecule consisting of large numbers (>10) of monosaccharide residues, that is, simple carbohydrate residues each consisting of a single basic sugar unit with the general formula (CH2O)n, linked glycosidically." ;
rdfs:subClassOf obo:XCO_0000172 .
obo:XCO_0001301 a rdfs:Class ;
rdfs:label "AEGE extract" ;
rdfs:comment "This is any condition in which the main influencing factor is AEGE extract, an herbal mixture extracted from the dried roots and rhizomes or stems of Acanthopanax senticosus Harms (ASH; Eleutherococcus senticosus; Siberian Ginseng) and Gastrodia elata Blume (Tianma; GE)." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0001796 a rdfs:Class ;
rdfs:label "experimental spinal cord transection" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy and complete transection of the isolated section of spinal cord." ;
rdfs:subClassOf obo:XCO_0001091 .
obo:XCO_0000662 a rdfs:Class ;
rdfs:label "two-kidney, one-clip occlusion" ;
rdfs:comment "A surgical manipulation causing blood vessel blockage by the clipping of one renal artery." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0001169 a rdfs:Class ;
rdfs:label "controlled ethanol content deionized water used as vehicle" ;
rdfs:comment "This is any condition in which the vehicle is made up of deionized water and a specified amount of ethanol, serving as a solvent for some specified chemical." ;
rdfs:subClassOf obo:XCO_0001119 .
obo:XCO_0000997 a rdfs:Class ;
rdfs:label "transfer of negative control siRNA using Lipofectamine reagent" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of negative control siRNA (small interfering RNA) delivered with Lipofectamine. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells." ;
rdfs:subClassOf obo:XCO_0001510 .
obo:XCO_0001354 a rdfs:Class ;
rdfs:label "vancomycin hydrochloride" ;
rdfs:comment "This is any condition in which the main influencing factor is vancomycin hydrochloride, the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide used for the treatment of certain bacterial infections, such as infections caused by Clostridium difficile and Staphylococcus aureus." ;
rdfs:subClassOf obo:XCO_0000572 .
obo:XCO_0000842 a rdfs:Class ;
rdfs:label "nicotinic antagonist" ;
rdfs:comment "Any condition in which the main influencing factor is a nicotinic antagonist, a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors." ;
rdfs:subClassOf obo:XCO_0000630 .
obo:XCO_0000228 a rdfs:Class ;
rdfs:label "peptide hormone" ;
rdfs:comment "A molecular chain compound composed of two or more amino acids joined by peptide bonds that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body." ;
rdfs:subClassOf obo:XCO_0000125 , obo:XCO_0000193 .
obo:CHEBI_5001 a rdfs:Class .
obo:XCO_0000147 a rdfs:Class ;
rdfs:label "physiological salt solution perfusate" ;
rdfs:comment "A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood." ;
rdfs:subClassOf obo:XCO_0000117 .
obo:XCO_0000430 a rdfs:Class ;
rdfs:label "silymarin" ;
rdfs:comment "This is any condition in which the main influencing factor is silymarin, a strongly antioxidant mixture of flavonolignans extracted from the milk thistle plant (Silybum marianum). The components or silymarin are capable of scavenging both free radicals and reactive oxygen species (ROS)." ;
rdfs:subClassOf obo:XCO_0000271 .
obo:XCO_0000187 a rdfs:Class ;
rdfs:label "trimethaphan camsylate" ;
rdfs:comment "A drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia by acting as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor." ;
rdfs:subClassOf obo:XCO_0000842 .
obo:XCO_0000022 a rdfs:Class ;
rdfs:label "controlled sodium content diet" ;
rdfs:comment "A regimen of solid food in which the amount of sodium consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001558 a rdfs:Class ;
rdfs:label "ventral trunk of subdiaphragmatic vagus nerve direct electrical stimulation sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is ventral trunk of subdiaphragmatic vagus nerve direct electrical stimulation sham procedure. This procedure involves all the surgical maneuvers and implantations minus the electrode leads." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0001109 a rdfs:Class ;
rdfs:label "glycosaminoglycan" ;
rdfs:comment "This is any condition in which the main influencing factor is a glycosaminoglycan, any polysaccharide composed of repeating disaccharide units and containing a substantial proportion of amino monosaccharide residues. Glycosaminoglycans are constituents of mucoproteins, glycoproteins, and blood-group substances." .
obo:XCO_0000539 a rdfs:Class ;
rdfs:label "doxorubicin" ;
rdfs:comment "An experimental condition in which the main influencing factor is doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000482 .
obo:XCO_0000413 a rdfs:Class ;
rdfs:label "birth" ;
rdfs:comment "The emergence and separation of offspring from the body of the mother." ;
rdfs:subClassOf obo:XCO_0000411 .
obo:XCO_0001428 a rdfs:Class ;
rdfs:label "rat Schwann cell precursors" ;
rdfs:comment "This is a condition in which the main influencing factor is rat Schwann cell precursors, glioblasts that develop from migratory neural crest cells about embryonic day 12-14 (E12-E14) in the rat. The Schwann cell precursors are embedded among neurons (axons) with minimal extracellular space separating them from nerve cell membranes and have no basal lamina." .
obo:XCO_0001760 a rdfs:Class ;
rdfs:label "experimental, surgery-induced osteoarthritis of the knee joint" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental, surgery-induced osteoarthritis of the knee joint. A model of osteoarthritis of the knee can be established in rodents by excision of the medial collateral ligament, anterior cruciate ligament, and the medial meniscus, followed by daily forced activity. This procedure is a modified Hulth method of establishing osteoarthritis of the knee (KOA)." ;
rdfs:subClassOf obo:XCO_0001759 .
obo:XCO_0000959 a rdfs:Class ;
rdfs:label "Guanabenz" ;
rdfs:comment "This is any condition in which the main influencing factor is a dichlorobenzene derivative that is a cell-permeable α2-adrenoceptor agonist used as an antihypertensive agent." ;
rdfs:subClassOf obo:XCO_0000673 , obo:XCO_0000863 .
obo:XCO_0001368 a rdfs:Class ;
rdfs:label "medial meniscus transection sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a medial meniscus transection sham procedure, which follows the same surgical process as a medial meniscus transection without cutting the medial meniscus." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0001651 a rdfs:Class ;
rdfs:label "specific pathogen-free diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a specific-pathogen-free diet, a diet formulated and provided to animals that are maintained in an SPF (specific-pathogen-free) environment, meaning they are free of certain identified pathogens. SPF diets are typically designed to be sterile and free of pathogens, and they often include ingredients like autoclaved standard chow pellets and sterilized water." ;
rdfs:subClassOf obo:XCO_0000019 .
obo:XCO_0001600 a rdfs:Class ;
rdfs:label "citrate salt" ;
rdfs:comment "This is any condition in which the main influencing factor is citrate salt, a salt of citric acid." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0000107 a rdfs:Class ;
rdfs:label "pentobarbital" ;
rdfs:comment "Short to intermediate acting barbiturate used as a sedative and hypnotic." ;
rdfs:subClassOf obo:XCO_0000106 .
obo:XCO_0001580 a rdfs:Class ;
rdfs:label "pterostilbene" ;
rdfs:comment "This is any condition in which the main influencing factor is pterostilbene, a polyphenol which is an antioxidant, antineoplastic agent, and anti-inflammatory agent." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000435 , obo:XCO_0000505 .
obo:XCO_0001499 a rdfs:Class ;
rdfs:label "inferior vena cava ligation" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical narrowing of the lumen of the inferior vena cava by suture ligation, typically done caudal of the renal veins for establishing a model of deep vein thrombosis (DVT). Typically, side branches of the IVC caudal to the renal veins are fully ligated in this DVT model." ;
rdfs:subClassOf obo:XCO_0000596 .
obo:XCO_0001662 a rdfs:Class ;
rdfs:label "Jiawei Lianpu Yin" ;
rdfs:comment "This is any condition in which the main influencing factor is Jiawei Lianpu Yin, a compound formula used in traditional Chinese medicine (TCM). Jiawei Lianpu Yin is a combination of eleven different herbal ingredients. It has been used to treat gastric disorders." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000604 a rdfs:Class ;
rdfs:label "Aprotinin" ;
rdfs:comment "Any condition in which the main influencing factor is Aprotinin, also known as bovine pancreatic trypsin inhibitor (BPTI), a proteinase inhibitor used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery." ;
rdfs:subClassOf obo:XCO_0000748 .
obo:XCO_0000176 a rdfs:Class ;
rdfs:label "enzyme" ;
rdfs:comment "Any of numerous proteins or conjugated proteins produced by living organisms and functioning as specialized catalysts for biochemical reactions." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0000637 a rdfs:Class ;
rdfs:label "cyclosporine A" ;
rdfs:comment "A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle." ;
rdfs:subClassOf obo:XCO_0000636 .
obo:XCO_0000295 a rdfs:Class ;
rdfs:label "diethylstilbestrol" ;
rdfs:comment "A synthetic estrogen analog with chemical formula C18H20O2. The structure is similar to that of estrogen but lacks the complete four ring structure. As a drug it is used to treat prostatic and sometimes breast carcinomas. It is an epigenetic carcinogen." ;
rdfs:subClassOf obo:XCO_0000294 , obo:XCO_0000435 .
obo:XCO_0000315 a rdfs:Class ;
rdfs:label "buffer solution" ;
rdfs:comment "A homogeneous mixture of molecules, atoms and/or ions, one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000314 , obo:XCO_0000340 .
obo:XCO_0001264 a rdfs:Class ;
rdfs:label "phloretin" ;
rdfs:comment "This is any condition in which the main influencing factor is phloretin, an antineoplastic agent and natural dihydrochalcone found in many fruits." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000435 .
obo:XCO_0000990 a rdfs:Class ;
rdfs:label "Neurobasal medium" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is Neurobasal medium, a culture medium formulated to meet the special requirements of neuronal cells. This medium allows for the long-term maintenance of normal phenotype and growth of neuronal cells, and the maintenance of pure populations of neuronal cells without the need of an astrocyte feeder layer." ;
rdfs:subClassOf obo:XCO_0000966 .
obo:XCO_0000441 a rdfs:Class ;
rdfs:label "controlled 2-acetamidofluorene content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, consumed by a subject." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000804 a rdfs:Class ;
rdfs:label "laser therapy" ;
rdfs:comment "Any biomedical use of lasers for purposes designed to improve the state of the subject. Light from a laser is tuned to specific wavelengths and is a beam of coherent electromagnetic radiation usually in the ultraviolet, visible, or infrared regions of the spectrum." ;
rdfs:subClassOf obo:XCO_0000045 .
obo:XCO_0000158 a rdfs:Class ;
rdfs:label "physical restraint in mechanical restrainer" ;
rdfs:comment "The use of mechanical means, i.e. a manufactured apparatus or machine, to limit some or all of an animal's normal movements." ;
rdfs:subClassOf obo:XCO_0000157 .
obo:XCO_0001608 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to standard rat chow diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to a standard rat chow diet that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) standard rat chow diet on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000016 .
obo:XCO_0001071 a rdfs:Class ;
rdfs:label "L-cysteine" ;
rdfs:comment "This is any condition in which the main influencing factor is L-cysteine, an optically active form of cysteine having the L-configuration at the alpha-carbon. It is a thiol-containing non-essential amino acid that is oxidized to form cystine." ;
rdfs:subClassOf obo:XCO_0000119 .
obo:XCO_0000003 a rdfs:Class ;
rdfs:label "resting on treadmill" ;
rdfs:comment "A state in which the organism is on an non-operating exercise machine in which there is an endless belt that moves when operational so that the organism can walk or run in place." ;
rdfs:subClassOf obo:XCO_0000002 .
obo:XCO_0001622 a rdfs:Class ;
rdfs:label "Angelica dahurica" ;
rdfs:comment "This is any condition in which the main influencing factor is Angelica dahurica, whose root is a well-known traditional Chinese medicine (TCM). Angelica dahurica and Corydalis yanhusuo are the main ingredients of Yuanhu Zhitong Prescription" ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000160 a rdfs:Class ;
rdfs:label "receptor antagonist" ;
rdfs:comment "A substance that binds to a receptor without eliciting a biological response, blocking binding of substances that could elicit such responses." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0000916 a rdfs:Class ;
rdfs:label "gelled diet" ;
rdfs:comment "This is a regimen of semisolid food in which the amount of solid elements and water in the diet are controlled. The diet resembles jelly in consistency and is about 62.5% H2O, 37.5% synthetic food (Ziegler Bros., formula 53140000),0.3% NaCl, and 0.3% agar wt/wt." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0000118 a rdfs:Class ;
rdfs:label "perfusate suspended" ;
rdfs:comment "A condition in which a fluid which has been injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel, remains in but is no longer actively passed through the organ or tissue for a specified period of time." ;
rdfs:subClassOf obo:XCO_0000115 .
obo:XCO_0001285 a rdfs:Class ;
rdfs:label "oxaliplatin" ;
rdfs:comment "This is any condition in which the main influencing factor is oxaliplatin, an organoplatinum complex that is a commonly used as a chemothrepeutic drug for treatment of metastatic colorectal cancer." ;
rdfs:subClassOf obo:XCO_0000435 .
obo:XCO_0000342 a rdfs:Class ;
rdfs:label "chemical with specified structure" ;
rdfs:comment "This is any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, where that molecular composition explicitly contains one or more particular parts or groups that are held or put together in a particular way." ;
rdfs:subClassOf obo:XCO_0000088 .
obo:XCO_0000509 a rdfs:Class ;
rdfs:label "ultrasonic stimulus" ;
rdfs:comment "An auditory stimulus consisting of sound waves which are beyond the upper limit of perception by the human ear." ;
rdfs:subClassOf obo:XCO_0000048 .
obo:XCO_0000036 a rdfs:Class ;
rdfs:label "housing with socially dominant partner" ;
rdfs:subClassOf obo:XCO_0000035 , obo:XCO_0000490 .
obo:XCO_0000171 a rdfs:Class ;
rdfs:label "radioactively labeled chemical" ;
rdfs:comment "Chemical into which a radioactive element has been incorporated as a tracer." ;
rdfs:subClassOf obo:XCO_0000169 .
obo:XCO_0000718 a rdfs:Class ;
rdfs:label "gadolinium-based contrast agent" ;
rdfs:comment "This is any condition in which the main influencing factor is a Gadolinium-Based Contrast Agent (GBCA), an intravenous drug used in diagnostic imaging procedures to enhance the quality of magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA)." ;
rdfs:subClassOf obo:XCO_0000717 .
obo:XCO_0000452 a rdfs:Class ;
rdfs:label "controlled casein content diet" ;
rdfs:comment "A solid diet in which the amount of casein is maintained at a specified level. Casein, a phosphoprotein, is the principle protein component of milk." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001673 a rdfs:Class ;
rdfs:label "peripheral nerve stump conduit implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is a peripheral nerve stump conduit implantation, which aids the regeneration of a nerve from a proximal stump caused by transection, ablation, or other damage. Ideally, the conduit guides the regenerating nerve from the proximal to distal stump, therefore replacing the portion of the nerve that has been damaged or removed. Materials used for nerve conduits may be natural or synthetic, absorbable or nonabsorbable." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0001810 a rdfs:Class ;
rdfs:label "Chlorella-derived hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of Chlorella-derived hydrogel, a microalgae-based biomaterial that is able to photosynthetically generate oxygen in response to light, allowing for controlled oxygen delivery to hypoxic microenvironments in injury or disease." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0001723 a rdfs:Class ;
rdfs:label "enolase 2 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is enolase 2 (ENO2) presented as multiple antigenic peptides (MAPs), which are four copies of the same peptide epitope synthesized on a lysine-based core (MAPs-4 system)." ;
rdfs:subClassOf obo:XCO_0001707 .
obo:XCO_0001536 a rdfs:Class ;
rdfs:label "gene transfer of the mouse Vdr gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the mouse Vdr (vitamin D receptor) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Vdr in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0000814 a rdfs:Class ;
rdfs:label "partial body irradiation" ;
rdfs:comment "Partial body irradiation (PBI) is a form of radiotherapy used to target certain organs or to study the effects of sublethal doses of radiation." ;
rdfs:subClassOf obo:XCO_0000043 .
obo:XCO_0000218 a rdfs:Class ;
rdfs:label "4-alpha-phorbol 12,13-didecanoate" ;
rdfs:comment "A phorbol ester analog that is an activator of TRPV4 (transient receptor potential cation channel, subfamily V, member 4) channels." ;
rdfs:subClassOf obo:XCO_0000217 .
obo:XCO_0000874 a rdfs:Class ;
rdfs:label "controlled in situ lung condition" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled in situ lung condition in which the internal or external environment of one or both lungs is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." ;
rdfs:subClassOf obo:XCO_0000166 .
obo:XCO_0000279 a rdfs:Class ;
rdfs:label "terpene" ;
rdfs:comment "Any of a large and diverse class of organic compounds which are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, which are derived biosynthetically from units of isoprene and which have the general molecular formula (CH2=C(CH3)CH=CH2)n where n is the number of linked isoprene units." ;
rdfs:subClassOf obo:XCO_0000276 .
obo:XCO_0000893 a rdfs:Class ;
rdfs:label "controlled ramipril content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of ramipril in which the amount of ramipril consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001280 a rdfs:Class ;
rdfs:label "open field task" ;
rdfs:comment "This is any condition in which the main influencing factor is the open field task, which is designed to measure the movement and other behavior exhibited by a subject responding to an experimentally defined, open space. The open field test is used to assess activity and behavior in laboratory animals, usually rodents." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0000385 a rdfs:Class ;
rdfs:label "glomerulonephritis-inducing agent" ;
rdfs:comment "Any substance, such as a chemical, a mix of chemicals or a pathogen, which has the capacity to cause the development of the symptoms of glomerulonephritis, kidney inflammation characterized by inflammation of the capillary loops in the renal glomeruli." ;
rdfs:subClassOf obo:XCO_0000258 .
obo:XCO_0001227 a rdfs:Class ;
rdfs:label "teriparatide" ;
rdfs:comment "This is any condition in which the main influencing factor is teriparatide, a recombinant human parathyroid hormone analogue that is used to treat osteoporosis in women or men with a high risk for bone fracture. Teriparatide is made up of the first amino(N)-terminal 34 amino acids of human PTH (parathyroid hormone) and is an osteoanabolic agent." ;
rdfs:subClassOf obo:XCO_0000228 .
obo:XCO_0001850 a rdfs:Class ;
rdfs:label "hematoma aspiration" ;
rdfs:comment "This is any condition in which the main influencing factor is hematoma aspiration, a procedure in which blood is removed from a hematoma (a collection of blood outside of blood vessels) using a needle or catheter." ;
rdfs:subClassOf obo:XCO_0001100 .
obo:XCO_0000239 a rdfs:Class ;
rdfs:label "toxic substance" ;
rdfs:comment "A chemical or biological substance which is capable of causing illness, debilitation or death, to living organisms, tissues or cells." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000821 a rdfs:Class ;
rdfs:label "gene transfer of the rat GDNF gene using the plasmid vector pVAX2" ;
rdfs:comment "A condition in which the rat GDNF gene has been (transiently or stably) transferred into a cell or organism using the plasmid vector pVAX2 in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000819 .
obo:XCO_0001670 a rdfs:Class ;
rdfs:label "controlled air ozone content" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled air ozone content surrounding an organism or breathed by the organism as part of an experiment. Ozone (trioxygen) is an inorganic molecule made up of three oxygen atoms." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0000766 a rdfs:Class ;
rdfs:label "rat anti-26 kDa T cell line" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni." ;
rdfs:subClassOf obo:XCO_0000765 .
obo:XCO_0000198 a rdfs:Class ;
rdfs:label "pH indicator" ;
rdfs:comment "Any substance that indicates the concentration of hydrogen ions, that is the acidity level, of a solution by means of a characteristic change, especially in color." ;
rdfs:subClassOf obo:XCO_0000197 .
obo:XCO_0000347 a rdfs:Class ;
rdfs:label "blood vessel occlusion" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical manipulation causing blockage of a blood vessel, any one of the network of muscular tubes that carry blood through the body." ;
rdfs:subClassOf obo:XCO_0000596 .
obo:XCO_0001785 a rdfs:Class ;
rdfs:label "unilateral diaphragm denervation sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a unilateral diaphragm denervation sham procedure, which follows the same surgical process as a unilateral diaphragm denervation without transecting or resecting a phrenic nerve." ;
rdfs:subClassOf obo:XCO_0000100 , obo:XCO_0001782 .
obo:XCO_0000380 a rdfs:Class ;
rdfs:label "phytyl side chain of alpha-tocopherol" ;
rdfs:comment "A condition in which the main influencing factor is a hydrophobic 13 carbon saturated chain with methyl side groups at the 4', 8' and 12' positions. In its native form, the molecule is attached to the 2-carbon of the benzopyran-6-ol double ring structure of alpha-tocopherol." ;
rdfs:subClassOf obo:XCO_0000276 .
obo:XCO_0000909 a rdfs:Class ;
rdfs:label "potassium salt" ;
rdfs:comment "A condition in which the main influencing factor is any alkali metal salt having potassium(1+) as the cation." ;
rdfs:subClassOf obo:XCO_0000150 .
obo:XCO_0001365 a rdfs:Class ;
rdfs:label "consumption" ;
rdfs:comment "This is any condition in which the main influencing factor is diet-like consumption, the act or process of consuming food, drink, or other substance by way of an oral route into the body." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001152 a rdfs:Class ;
rdfs:label "diltiazem" ;
rdfs:comment "This is any condition whose main influencing factor is diltiazem, a benzothiazepine derivative that is a calcium-channel blocker and vasodilator. Diltiazem is used in the hydrochloride form in the management of angina pectoris and hypertension." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000269 , obo:XCO_0000863 .
obo:XCO_0000889 a rdfs:Class ;
rdfs:label "ionomycin" ;
rdfs:comment "Ionomycin is a very long-chain fatty acid that is a calcium ionophore produced by Streptomyces conglobatus. It is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes." ;
rdfs:subClassOf obo:XCO_0000776 , obo:XCO_0000890 .
obo:XCO_0000599 a rdfs:Class ;
rdfs:label "aldosterone" ;
rdfs:comment "A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0000985 a rdfs:Class ;
rdfs:label "transfer of rat wild type Ccny-specific shRNA using a lentivirus vector" ;
rdfs:comment "This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0001537 .
obo:XCO_0001774 a rdfs:Class ;
rdfs:label "IDPN" ;
rdfs:comment "This is any condition in which the main influencing factor is IDPN (3,3'-iminodipropionitrile), an organic compound formed from ammonia and acrylonitrile. 3,3'-iminodipropionitrile is a neurotoxin with ototoxic and hepatotoxic effects." ;
rdfs:subClassOf obo:XCO_0000495 .
obo:XCO_0000911 a rdfs:Class ;
rdfs:label "sodium bicarbonate" ;
rdfs:comment "This is any condition in which the main influencing factor is sodium bicarbonate, a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions." .
obo:XCO_0000203 a rdfs:Class ;
rdfs:label "bilateral orchiectomy" ;
rdfs:comment "Surgical removal of both testes." ;
rdfs:subClassOf obo:XCO_0000201 .
obo:XCO_0001596 a rdfs:Class ;
rdfs:label "OM-85" ;
rdfs:comment "This is any condition in which the main influencing factor is OM-85, an immunostimulanting combination of molecules extracted from the walls of bacteria that commonly cause respiratory infections. OM-85 can enhance immunity by promoting the maturation of dendritic cells in the gastrointestinal Peyer's patches, which in turn strengthens immune defenses in the lung." ;
rdfs:subClassOf obo:XCO_0000505 , obo:XCO_0000761 .
obo:XCO_0000043 a rdfs:Class ;
rdfs:label "X-ray exposure" ;
rdfs:comment "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between approximately 0.01 and 10 nm." ;
rdfs:subClassOf obo:XCO_0000039 .
obo:XCO_0000730 a rdfs:Class ;
rdfs:label "endothelin receptor antagonist" ;
rdfs:comment "Any condition in which the main influencing factor is an agent that blocks one or more endothelin receptors." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001843 a rdfs:Class ;
rdfs:label "tetrahedral DNA nanostructure" ;
rdfs:comment "This is any condition in which the main influencing factor is tetrahedral DNA nanostructures (TDNs), self-assembled tetrahedral framework nucleic acids that exhibit structural stability, biocompatibility, and efficient cellular uptake. The applications of TDNs include drug delivery, targeted therapy, and biosensing." ;
rdfs:subClassOf obo:XCO_0000234 .
obo:XCO_0000729 a rdfs:Class ;
rdfs:label "enrasentan" ;
rdfs:comment "Enrasentan is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor." ;
rdfs:subClassOf obo:XCO_0000730 .
obo:XCO_0000370 a rdfs:Class ;
rdfs:label "Trichinella spiralis" ;
rdfs:comment "A condition in which the main influencing factor is any form of Trichinella spiralis, a nematode parasite that occurs in animals such as rodents, pigs, bears, and in humans. The organism, which matures in the intestines, producing larvae that travel through the blood and lymphatic systems to the muscles where they encyst, is responsible for the disease trichinosis." ;
rdfs:subClassOf obo:XCO_0000363 .
obo:XCO_0000795 a rdfs:Class ;
rdfs:label "controlled sodium chloride content diet" ;
rdfs:comment "A regimen of solid food in which the amount of sodium chloride consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000022 .
obo:XCO_0001466 a rdfs:Class ;
rdfs:label "3-chloro-1,2-propanediol" ;
rdfs:comment "This is any condition in which the main influencing factor is 3-chloro-1,2-propanediol, a chlorinated propanediol with antifertility activity in males used as a chemosterilant in rodents." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000427 a rdfs:Class ;
rdfs:label "lycopene" ;
rdfs:comment "A condition in which the main influencing factor is lycopene, a bright red polyunsaturated carotenoid hydrocarbon (i.e. a carotene) with the formula C40H56. Lycopene is a tetraterpene assembled from eight isoprene units and has antioxidant activity." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000279 .
obo:XCO_0000134 a rdfs:Class ;
rdfs:label "methacholine" ;
rdfs:comment "A synthetic choline ester that acts as a non-selective muscarinic receptor agonist, that is, a chemical which when bound to the receptor produces a physiologic reaction typical of the naturally occurring ligand, in the parasympathetic nervous system." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000600 a rdfs:Class ;
rdfs:label "2,3,7,8-tetrachlorodibenzo-p-dioxin" ;
rdfs:comment "This is any condition in which the main influencing factor is 2,3,7,8-tetrachlorodibenzo-p-dioxin, a polychlorinated dibenzo-p-dioxin that activates the aryl hydrocarbon (AH) receptor, a transcription factor." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0001630 a rdfs:Class ;
rdfs:label "desferrioxamine B" ;
rdfs:comment "This is any condition in which the main influencing factor is desferrioxamine B, a natural product native to Streptomyces pilosus that has a role as an iron chelator, a siderophore, a ferroptosis inhibitor and a bacterial metabolite." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0001631 .
obo:XCO_0000922 a rdfs:Class ;
rdfs:label "semaxanib" ;
rdfs:comment "An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has been used to produce pulmonary arterial hypertension in animal models." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0000259 , obo:XCO_0000523 .
obo:XCO_0000229 a rdfs:Class ;
rdfs:label "steroid hormone" ;
rdfs:comment "A condition in which the main influencing factor is a chemical substance the structure of which is based on the basic 17-carbon-atom ring system steroid nucleus but may or may not have the characteristic arrangement of four fused cycloalkane rings, and which is produced in its endogenous state by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue." ;
rdfs:subClassOf obo:XCO_0000091 , obo:XCO_0000125 .
obo:XCO_0001821 a rdfs:Class ;
rdfs:label "transfer of dCas9-VPR using a plasmid vector" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of dCas9-VPR DNA via a plasmid vector. dCas9-VPR is a transcriptional activator encoding the catalytically inactive “dead” CRISPR-associated endonuclease Cas9 (dCas9) fused to several different activation domains (VP64-p65-Rta) in series. When delivered to cells or organisms with guide RNA specifying a genomic target, it activates transcription of the targeted gene." ;
rdfs:subClassOf obo:XCO_0001819 .
obo:XCO_0000471 a rdfs:Class ;
rdfs:label "quercetin" ;
rdfs:comment "Condition in which the main influencing factor is quercetin, a pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is a yellow flavonoid pigment found in oak bark, the juice of lemons, asparagus, and other fruits and vegetables and is used to reduce abnormal capillary fragility." ;
rdfs:subClassOf obo:XCO_0000470 .
obo:XCO_0000683 a rdfs:Class ;
rdfs:label "cholestyramine" ;
rdfs:comment "A bile acid-binding anticholesteremic drug that helps decrease the risk for strokes and heart attacks." ;
rdfs:subClassOf obo:XCO_0000680 .
obo:XCO_0001710 a rdfs:Class ;
rdfs:label "guanine deaminase" ;
rdfs:comment "This is any condition in which the main influencing factor is guanine deaminase, an enzyme responsible for the hydrolytic deamination of guanine. Guanine deaminase plays a role in microtubule assembly." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000900 a rdfs:Class ;
rdfs:label "controlled hydrochlorothiazide content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydrochlorothiazide in which the amount of hydrochlorothiazide consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001216 a rdfs:Class ;
rdfs:label "controlled glucose content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of glucose consumed by a subject. Glucose is a monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues. Glucose is one of the three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion" ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001477 a rdfs:Class ;
rdfs:label "controlled 8-aminoguanine content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of 8-aminoguanine, a naturally occurring purine that is produced from precursors containing 8-nitroguanine, consumed by a subject." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000896 a rdfs:Class ;
rdfs:label "controlled hesperetin content diet" ;
rdfs:comment "A regimen of solid food in which the amount of hesperetin is controlled. Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000603 .
obo:XCO_0000867 a rdfs:Class ;
rdfs:label "incision repair" ;
rdfs:comment "A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures, staples, glue, or some other closure material." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000788 a rdfs:Class ;
rdfs:label "S4MH cells" ;
rdfs:comment "A condition in which the main influencing factor is a rat rhabdomyosarcoma cell line used to study metastasis." ;
rdfs:subClassOf obo:XCO_0000709 .
obo:XCO_0000369 a rdfs:Class ;
rdfs:label "aurothiopropanol sulfonate" ;
rdfs:comment "An antirheumatic of slow action that, in certain susceptible individuals, causes a gold-induced, Th2-dependent autoimmunity." ;
rdfs:subClassOf obo:XCO_0000368 .
obo:XCO_0001861 a rdfs:Class ;
rdfs:label "sensory nerve autograft" ;
rdfs:comment "This is any condition in which the main influencing factor is sensory nerve autograft, implantation/transplantation of autologous sensory nerve tissue. This is a surgical procedure intended to restore lost or impaired sensory nerve function." ;
rdfs:subClassOf obo:XCO_0001860 .
obo:XCO_0000933 a rdfs:Class ;
rdfs:label "argipressin" ;
rdfs:comment "This molecule is the predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6." ;
rdfs:subClassOf obo:XCO_0000932 .
obo:XCO_0000200 a rdfs:Class ;
rdfs:label "4-methyl-2-oxopentanoic acid" ;
rdfs:comment "A monocarboxylic acid that serves as an intermediate in the metabolism of leucine and a substrate for NADPH-dependent dehydrogenases." ;
rdfs:subClassOf obo:XCO_0000136 .
obo:XCO_0000927 a rdfs:Class ;
rdfs:label "hydroxypolyether" ;
rdfs:comment "A hydroxyether compound containing more than one ether group." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001503 a rdfs:Class ;
rdfs:label "alfacalcidol" ;
rdfs:comment "This is any condition in which the main influencing factor is alfacalcidol, a member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism." ;
rdfs:subClassOf obo:XCO_0000545 .
obo:XCO_0001296 a rdfs:Class ;
rdfs:label "blood transfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is blood transfusion, an intravenous transfer of blood or blood components from one subject to another or from one subject back to the same subject (after treatment or storage of blood/blood product)." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0000251 a rdfs:Class ;
rdfs:label "secretagogue" ;
rdfs:comment "Any agent that induces exocrine, endocrine, or paracrine secretion." ;
rdfs:subClassOf obo:XCO_0000214 .
obo:XCO_0000694 a rdfs:Class ;
rdfs:label "enzyme activator" ;
rdfs:comment "Any substance that combines with an enzyme to increase its catalytic activity. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism" ;
rdfs:subClassOf obo:XCO_0000214 .
obo:XCO_0001060 a rdfs:Class ;
rdfs:label "controlled corticosterone content saline drink" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of normal saline (0.9% sodium chloride) and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0001059 .
obo:XCO_0001119 a rdfs:Class ;
rdfs:label "deionized water" ;
rdfs:comment "This is any condition in which the main influencing factor is deionized water, a form of purified water that is filtered through one or two tanks of ion-exchange resin which replaces cations with hydrogen (H+) ions and anions with hydroxyl (OH-) ions, leaving a mineral-free water." ;
rdfs:subClassOf obo:XCO_0000021 .
obo:XCO_0001816 a rdfs:Class ;
rdfs:label "interleukin-1 receptor antagonist" ;
rdfs:comment "This is any condition in which the main influencing factor is an interleukin-1 receptor antagonist, an agent that blocks interleukin-1 receptors." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000358 a rdfs:Class ;
rdfs:label "diagnostic agent" ;
rdfs:comment "A substance administered specifically to aid diagnosis of a disease or condition." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000408 a rdfs:Class ;
rdfs:label "metformin" ;
rdfs:comment "A condition in which the main influencing factor is metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis)." ;
rdfs:subClassOf obo:XCO_0000407 .
obo:XCO_0001199 a rdfs:Class ;
rdfs:label "oxandrolone" ;
rdfs:comment "This is any condition in which the main influencing factor is oxandrolone, a synthetic, anabolic steroid hormone analog of testosterone." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000229 .
obo:XCO_0000632 a rdfs:Class ;
rdfs:label "saxagliptin" ;
rdfs:comment "A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes. It belongs to the biological class EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor ." ;
rdfs:subClassOf obo:XCO_0000407 , obo:XCO_0000523 .
obo:XCO_0001525 a rdfs:Class ;
rdfs:label "multigenerational parental exposure to controlled air oxygen content" ;
rdfs:comment "This is any condition in which the main influencing factor is any parental exposure to controlled air oxygen content that has multigenerational effects. This is a condition typically studied to determine the effect of maternal/paternal (F0) controlled air oxygen content exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring. Paternal exposure to controlled air oxygen content may occur anytime before successful copulation." ;
rdfs:subClassOf obo:XCO_0000010 .
obo:XCO_0001104 a rdfs:Class ;
rdfs:label "QUAN-0808" ;
rdfs:comment "This is any condition in which the main influencing factor is Q808, an experimental phthalazine tetrazole derivative being tested for effectiveness as an anti-inflammatory, anticonvulsant, and analgesic drug." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000505 , obo:XCO_0000950 .
obo:XCO_0000075 a rdfs:Class ;
rdfs:label "tea" ;
rdfs:subClassOf obo:XCO_0000028 .
obo:XCO_0001633 a rdfs:Class ;
rdfs:label "gene transfer of the Gja1 gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the gap junction protein, alpha 1 gene (Gja1) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0001184 a rdfs:Class ;
rdfs:label "mibefradil" ;
rdfs:comment "This is any condition in which the main influencing factor is mibefradil, a benzimidazoyl-substituted tetralin that selectively binds and inhibits T-type calcium channels. Mibefradil is a vasodilator and antihypertensive agent." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000269 , obo:XCO_0000863 .
obo:XCO_0001514 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to methylazoxymethanol acetate" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to methylazoxymethanol acetate that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) methylazoxymethanol acetate use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001513 .
obo:XCO_0000401 a rdfs:Class ;
rdfs:label "nerve root avulsion" ;
rdfs:comment "The surgical tearing apart of the nerve root, the part of a nerve adjacent to the center to which it is connected, from that center, for example, surgical separation of one or both of two bundles of nerve fibers (the posterior and anterior roots) from the spinal cord by tearing rather than cutting." ;
rdfs:subClassOf obo:XCO_0000373 , obo:XCO_0000400 .
obo:XCO_0001805 a rdfs:Class ;
rdfs:label "transfer of human histone variant H3-3A using a lentivirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is wild-type human histone variant H3-3A which has been (transiently or stably) transferred into a cell or organism using a lentivirus vector in order to induce synthesis of that product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000982 .
obo:XCO_0001417 a rdfs:Class ;
rdfs:label "transgenerational maternal exposure to folic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to folic acid that has transgenerational effects. This is a condition typically studied to determine the effect of maternal (F0) folic acid use/exposure on the F2/F3 offspring by direct effects on the F1/F2 generations in utero or during nursing, or by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of F1 offspring to affect the F2 generation. The maternal exposure may be any time after gestational development of germline cells in the F1 generation up to the time of weaning of F1 offspring to affect the F3 generation." ;
rdfs:subClassOf obo:XCO_0001113 .
obo:XCO_0001000 a rdfs:Class ;
rdfs:label "mechanical ventilation with assist/control" ;
rdfs:comment "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with assist/control (A/C), meaning the breathing rate is set and the tidal volume or pressure is set. When the subject triggers a breath, a full set tidal volume (or pressure) breath is delivered. When the vent delivers a subject-triggered breath, the next breath is timed in relation to this." ;
rdfs:subClassOf obo:XCO_0000999 .
obo:XCO_0000224 a rdfs:Class ;
rdfs:label "ruthenium red" ;
rdfs:comment "An inorganic dye which also intereacts with many types of proteins including ion channels and enzymes." ;
rdfs:subClassOf obo:XCO_0000222 .
obo:XCO_0001698 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to collapsin response mediator protein 1 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to an autoantibody-generating level of collapsin response mediator protein 1 (CRMP1) multiple antigenic peptides (MAPs) that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) CRMP1 exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001725 .
obo:XCO_0001379 a rdfs:Class ;
rdfs:label "4,4'-diaminodiphenylmethane" ;
rdfs:comment "This is any condition in which the main influencing factor is 4,4'-diaminodiphenylmethane, an aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000611 a rdfs:Class ;
rdfs:label "nifedipine" ;
rdfs:comment "This is any condition in which the main influencing factor is nifedipine, a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000269 .
obo:XCO_0000130 a rdfs:Class ;
rdfs:label "ketamine" ;
rdfs:comment "An analgesic and anesthetic which functions as a noncompetitive NMDA receptor (NMDAR) antagonist, binding to the allosteric site of the NMDA receptor and effectively inhibiting its channel." ;
rdfs:subClassOf obo:XCO_0000947 .
obo:XCO_0001585 a rdfs:Class ;
rdfs:label "gestational maternal exposure to dimethyl sulfoxide" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to dimethyl sulfoxide. This is a condition typically studied to determine the effect of maternal (F0) dimethyl sulfoxide use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001584 .
obo:XCO_0000831 a rdfs:Class ;
rdfs:label "2% dimethyl sulfoxide in artificial cerebrospinal fluid" ;
rdfs:comment "Any condition in which the main influencing factor is a 2% solution (v/v) of dimethyl sulfoxide in artificial cerebrospinal fluid, a buffer solution prepared with a composition representative of cerebrospinal fluid. Dimethyl sulfoxide is a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent." .
obo:XCO_0001392 a rdfs:Class ;
rdfs:label "human placenta-derived mesenchymal stem cells" ;
rdfs:comment "This is any condition in which the main influencing factor is human, placenta-derived mesenchymal stem cells, which are isolated from various parts of the placenta from healthy maternal donors. They are mesenchymal stem cells that can be expanded in culture and are intermediate in characteristics between bone marrow-derived mesenchymal stem cells (BM-MSCs) and embryonic stem cells (ESCs)." ;
rdfs:subClassOf obo:XCO_0001393 .
obo:XCO_0001687 a rdfs:Class ;
rdfs:label "controlled BT2 content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled BT2 content diet, a regimen of solid food in which the amount of BT2 consumed is controlled. BT2 (3,6-Dichloro-1-benzothiophene-2-carboxylic acid) is a small-molecule BCKDK (branched chain ketoacid dehydrogenase kinase) inhibitor that enhances branched-chain amino acid (BCAA) catabolism." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000553 a rdfs:Class ;
rdfs:label "everolimus" ;
rdfs:comment "An experimental condition in which the main influencing factor is everolimus, a mammalian target of rapamycin (mTOR) inhibitor which is selective for the mTORC1 protein complex, with little or no effect on mTORC2. Everolimus is used as an antineoplastic and immunosuppressive agent." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0000948 a rdfs:Class ;
rdfs:label "Ro 25-6981" ;
rdfs:comment "This is a condition in which the main influencing factor is a member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor." ;
rdfs:subClassOf obo:XCO_0000947 .
obo:XCO_0001734 a rdfs:Class ;
rdfs:label "inosine" ;
rdfs:comment "This is any condition in which the main influencing factor is inosine, a purine nucleoside that is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in human tRNA molecules. Animal studies have suggested that inosine has neuroprotective properties" ;
rdfs:subClassOf obo:XCO_0000392 .
obo:XCO_0001205 a rdfs:Class ;
rdfs:label "perhexiline maleate" ;
rdfs:comment "This is any condition in which the main influencing factor is perhexiline maleate, a coronary vasodilator used as a prophylactic antianginal agent. Perhexiline inhibits mitochondrial carnitine palmitoyltransferase-1 and -2." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0001591 a rdfs:Class ;
rdfs:label "experimental T10/T11 spinal cord transection/scar resection" ;
rdfs:comment "This is any condition in which the main influencing factor is scar resection after healing of an experimental transection of the rat spinal cord at the vertebral level of thoracic 10/11 (T10/11). This procedure involves laminectomy of the tenth vertebra and complete transection of the isolated section of spinal cord. This procedure is followed by resection of the center (~1 mm) of the scar tissue formed (by ~ day 42) in the gap created by the transection." .
obo:XCO_0000032 a rdfs:Class ;
rdfs:label "controlled potassium content diet" ;
rdfs:comment "A regimen of solid food in which the amount of potassium consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001141 a rdfs:Class ;
rdfs:label "scrambled control oligonucleotide" ;
rdfs:comment "This is any condition in which the main influencing factor is a negative control oligonucleotide. A negative control oligonucleotide is an oligonucleotide with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental oligonucleotide used." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0001172 a rdfs:Class ;
rdfs:label "lopinavir" ;
rdfs:comment "This is any condition in which the main influencing factor is lopinavir, an HIV protease inhibitor used in a fixed-dose combination with ritonavir. Lopinavir is also a cytochrome P-450 inhibitor." ;
rdfs:subClassOf obo:XCO_0000657 , obo:XCO_0000748 .
obo:XCO_0001846 a rdfs:Class ;
rdfs:label "ladder climbing" ;
rdfs:comment "This is any condition in which the main influencing factor is ladder climbing, the act of ascending or descending a structure that consists essentially of two long sidepieces joined at intervals by crosspieces on which one may step." ;
rdfs:subClassOf obo:XCO_0001844 .
obo:XCO_0001686 a rdfs:Class ;
rdfs:label "BT2" ;
rdfs:comment "This is any condition in which the main influencing factor is BT2, a mitochondrial branched-chain α-ketoacid dehydrogenase (BCKD) kinase (BCKDK/BDK) inhibitor. BT2 is also an MCL1 (MCL1 apoptosis regulator, BCL2 family member) inhibitor." ;
rdfs:subClassOf obo:XCO_0000970 .
obo:XCO_0001242 a rdfs:Class ;
rdfs:label "tolcapone" ;
rdfs:comment "This is any condition in which the main influencing factor is tolcapone, a catechol O-methyltransferase (COMT) inhibitor used in the treatment of Parkinson disease." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001612 a rdfs:Class ;
rdfs:label "cinacalcet" ;
rdfs:comment "This is any condition in which the main influencing factor is cinacalcet, a secondary amino compound that is a member of the naphthalenes and the trifluoromethyl)benzenes. Cinacalcet is a calcium sensing receptor (CASR) agonist and a P450 inhibitor." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000523 .
obo:XCO_0000391 a rdfs:Class ;
rdfs:label "5-bromo-2'-deoxyuridine" ;
rdfs:comment "A condition in which the main influencing factor is 5-bromo-2'-deoxyuridine (BrdU), a synthetic nucleoside analog and antimetabolite of thymidine. Because BrdU substitutes for thymidine in DNA during replication its incorporation can be used as a marker of cell division." ;
rdfs:subClassOf obo:XCO_0000390 , obo:XCO_0000392 , obo:XCO_0000435 .
obo:XCO_0001462 a rdfs:Class ;
rdfs:label "thoracic aorta constriction sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a thoracic aortic constriction sham procedure, which follows the same surgical process as a thoracic aortic constriction without blocking the aorta." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000097 a rdfs:Class ;
rdfs:label "right ovariectomy" ;
rdfs:comment "Surgical removal of the right ovary." ;
rdfs:subClassOf obo:XCO_0000096 .
obo:XCO_0001708 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to enolase 2 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to an autoantibody-generating level of enolase 2 (ENO2) multiple antigenic peptides (MAPs) that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) ENO2 exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001723 .
obo:XCO_0001451 a rdfs:Class ;
rdfs:label "diagnostic imaging agent" ;
rdfs:comment "This is any condition in which the main influencing factor is a diagnostic imaging agent, a substance administered to enhance contrast in images of the inside of the body obtained using X-rays, gamma-rays, sound waves, radio waves (MRI), or radioactive particles." ;
rdfs:subClassOf obo:XCO_0000358 .
obo:XCO_0000825 a rdfs:Class ;
rdfs:label "cyclophosphamide" ;
rdfs:comment "An experimental condition in which the main influencing factor is cyclophosphamide (CP), an antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000636 .
obo:XCO_0001590 a rdfs:Class ;
rdfs:label "lung ischemia/reperfusion sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a lung ischemia/reperfusion sham procedure, which follows the same surgical process as an lung ischemia/reperfusion procedure without blocking the pulmonary hilum." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000163 a rdfs:Class ;
rdfs:label "controlled content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is drinking water in which the amount of one or more solutes are adjusted to a requirement." ;
rdfs:subClassOf obo:XCO_0000021 .
obo:XCO_0000808 a rdfs:Class ;
rdfs:label "DL-α-aminoadipate" ;
rdfs:comment "Any condition in which the main influencing factor is DL-α-aminoadipate. This excitatory amino acid analogue is an intermediate in the principal biosynthetic pathway of lysine. It is a also an inhibitor of glutamine synthetase." ;
rdfs:subClassOf obo:XCO_0000240 , obo:XCO_0000523 .
obo:XCO_0000423 a rdfs:Class ;
rdfs:label "thymoquinone" ;
rdfs:comment "A condition in which the main influencing factor is thymoquinone, an antioxidant phytochemical compound found in the plant Nigella sativa. Thymoquinone has the chemical formula C10H12O2 and is a 1,4-benzoquinone substituted at the 2 and 5 position with a methyl and an isopropyl group (2-Isopropyl-5-methyl- or 5-Isopropyl-2-methyl-)." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000422 .
obo:XCO_0000169 a rdfs:Class ;
rdfs:label "labeled chemical" ;
rdfs:comment "Any chemical to which a tracer has been added such as the addition of a fluorescent tag or inclusion of a radioactive element during synthesis." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001659 a rdfs:Class ;
rdfs:label "Urolithin A" ;
rdfs:comment "This is any condition in which the main influencing factor is Urolithin A, a coumarin that has various biological effects. Research on Urolithin A has found effects on diverse biological activities, encompassing anti-inflammatory, antioxidant, anti-tumor, and anti-aging properties." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000435 , obo:XCO_0000505 .
obo:XCO_0000114 a rdfs:Class ;
rdfs:label "left nephrectomy" ;
rdfs:comment "Surgical removal of the left kidney." ;
rdfs:subClassOf obo:XCO_0000112 .
obo:XCO_0001357 a rdfs:Class ;
rdfs:label "controlled ampicillin sodium content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of ampicillin sodium, the sodium salt form of ampicillin, a broad-spectrum semisynthetic derivative of aminopenicillin. Ampicillin sodium inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0001356 .
obo:XCO_0000659 a rdfs:Class ;
rdfs:label "controlled nisoldipine content diet" ;
rdfs:comment "A regimen of solid food in which the amount of nisoldipine consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000658 .
obo:XCO_0000459 a rdfs:Class ;
rdfs:label "controlled light/dark cycle" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled light/dark cycle in which an organism experiences multiple periods of controlled ambient light followed by exposure to darkness." ;
rdfs:subClassOf obo:XCO_0000182 .
obo:XCO_0001749 a rdfs:Class ;
rdfs:label "fenoprofen" ;
rdfs:comment "This is any condition in which the main influencing factor is fenoprofen, a monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. Fenoprofen is a non-steroidal anti-inflammatory drug pharmacologically similar to aspirin, but it causes less gastrointestinal bleeding." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0000614 a rdfs:Class ;
rdfs:label "rolipram" ;
rdfs:comment "A phosphodiesterase 4 inhibitor with antidepressant properties." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001782 a rdfs:Class ;
rdfs:label "unilateral diaphragm denervation" ;
rdfs:comment "This is any condition in which the main influencing factor is the transection or resection of either the left or right phrenic nerve. The phrenic nerves convey impulses between the central nervous system and the diaphragm." ;
rdfs:subClassOf obo:XCO_0001781 .
obo:XCO_0000594 a rdfs:Class ;
rdfs:label "saralasin" ;
rdfs:comment "This is any condition in which the main influencing factor is saralasin, a competitive angiotensin II receptor antagonist with partial agonistic activity previously used to distinguish renovascular hypertension from essential hypertension." ;
rdfs:subClassOf obo:XCO_0000536 .
obo:XCO_0001550 a rdfs:Class ;
rdfs:label "cellulose" ;
rdfs:comment "This is any condition whose main influencing factor is cellulose, a polysaccharide consisting of a linear chain of several hundred to many thousands of β(1→4) linked D-glucose units, occurs naturally in such fibrous products as cotton and kapok, and is the raw material of many manufactured goods (such as paper, rayon, and cellophane)." ;
rdfs:subClassOf obo:XCO_0000173 .
obo:XCO_0000420 a rdfs:Class ;
rdfs:label "controlled in utero environment" ;
rdfs:comment "A condition in which the environment of the offspring within the uterus is controlled during any or all of the period between fertilization and parturition." ;
rdfs:subClassOf obo:XCO_0000421 .
obo:XCO_0000810 a rdfs:Class ;
rdfs:label "2-Chloro-5-hydroxyphenylglycine" ;
rdfs:comment "Any condition in which the main influencing factor is 2-Chloro-5-hydroxyphenylglycine, a metabotropic glutamate receptor 5 agonist." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000497 a rdfs:Class ;
rdfs:label "Parkinson disease-inducing chemical" ;
rdfs:comment "A condition in which the main influencing factor is a synthetic or naturally derived compound that causes loss of dopaminergic neurons and induces Parkinson-like symptoms (parkinsonism) in animal models and/or Parkinson disease in humans." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0000129 a rdfs:Class ;
rdfs:label "obsolete water with NG-Nitroarginine Methyl Ester" ;
rdfs:comment "OBSOLETE. Drinking water with a specified concentration of NG-Nitroarginine Methyl Ester (L-NAME) added to it. L-NAME is used as a non-selective inhibitor of nitric oxide synthase." .
obo:XCO_0000673 a rdfs:Class ;
rdfs:label "alpha-adrenergic agonist" ;
rdfs:comment "This is any condition in which the main influencing factor is an alpha-adrenergic agonist, an agent that selectively binds to and activates alpha-adrenergic receptors." ;
rdfs:subClassOf obo:XCO_0000664 .
obo:XCO_0001346 a rdfs:Class ;
rdfs:label "enalaprilat" ;
rdfs:comment "This is any condition in which the main influencing factor is enalaprilat, the active metabolite of the orally available pro-drug enalapril. Used in the treatment of hypertension, heart failure, and nephropathies, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. Enalaprilat is enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid." ;
rdfs:subClassOf obo:XCO_0000542 .
obo:XCO_0000047 a rdfs:Class ;
rdfs:label "sensory stimulus" ;
rdfs:comment "An action or condition designed to cause the registration or perception of a stimulus and the voyage made by incoming nerve impulses from the sense organs to the nerve centers. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001727 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to Freund's adjuvant and saline" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to a mix of Freund's adjuvant and saline that serves as vehicle control for antibody-generating conditions that have multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) vehicle control exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001726 .
obo:XCO_0001403 a rdfs:Class ;
rdfs:label "controlled air nitrogen content" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled air nitrogen content surrounding an organism or breathed by the organism as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0000802 a rdfs:Class ;
rdfs:label "GSK1016790A" ;
rdfs:comment "It is a tertiary carboxamide and cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel." ;
rdfs:subClassOf obo:XCO_0000217 .
obo:XCO_0000273 a rdfs:Class ;
rdfs:label "carrageenan" ;
rdfs:comment "A family of linear, sulfated, high-molecular-weight polysaccharides made up of repeating galactose and 3,6-anhydrogalactose units with alternating alpha 1-3 and beta 1-4 glycosidic linkages." ;
rdfs:subClassOf obo:XCO_0000173 .
obo:XCO_0001767 a rdfs:Class ;
rdfs:label "L5 spinal nerve compression" ;
rdfs:comment "This is any condition in which the main influencing factor is the compression of the L5 spinal nerve by ligation of a cannula to the nerve root. This is an experimental model of L5 spinal nerve injury." ;
rdfs:subClassOf obo:XCO_0001026 .
obo:XCO_0000381 a rdfs:Class ;
rdfs:label "progesterone" ;
rdfs:comment "Condition in which the main influencing factor is the steroid hormone progesterone, the principal pro-gestational hormone liberated by the corpus luteum, adrenal cortex, and placenta, whose function is to prepare the uterus for the reception and development of the fertilized oocyte by inducing transformation of the endometrium from the proliferative to the secretory stage." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0000819 a rdfs:Class ;
rdfs:label "gene transfer using plasmid vector pVAX2" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer using plasmid pVAX2 as the carrier of the genetic material. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines." ;
rdfs:subClassOf obo:XCO_0000818 .
obo:XCO_0000589 a rdfs:Class ;
rdfs:label "Moexipril" ;
rdfs:comment "A condition in which the main influencing factor is Moexipril, a non-sulfhydryl-containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor Moexiprilat and a vasodilatory antihypertensive drug." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0000857 a rdfs:Class ;
rdfs:label "vildagliptin" ;
rdfs:comment "Any condition in which the main influencing factor is vildagliptin, a pyrrolidine-carbonitrile derivative and potent inhibitor of dipeptidyl peptidase 4 (DPP-4) that is used in the treatment of type 2 diabetes mellitus." ;
rdfs:subClassOf obo:XCO_0000407 .
obo:XCO_0000341 a rdfs:Class ;
rdfs:label "chemical with specified function" ;
rdfs:comment "This is any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules and which has the capacity to perform a particular role or initiate or participate in a particular activity or process." ;
rdfs:subClassOf obo:XCO_0000088 .
obo:XCO_0001025 a rdfs:Class ;
rdfs:label "UNC0638" ;
rdfs:comment "This is any condition in which the main influencing factor is UNC0638, a histone methyltransferase Inhibitor that is a trial drug for cancer." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000523 .
obo:XCO_0000419 a rdfs:Class ;
rdfs:label "soy-free diet" ;
rdfs:comment "A solid diet specifically containing no soy, that is, no derivative of soybeans, the bean of the leguminous plant, Glycine max, which contains little starch but is rich in protein and phytoestrogens." ;
rdfs:subClassOf obo:XCO_0000417 .
obo:XCO_0000561 a rdfs:Class ;
rdfs:label "antidepressant" ;
rdfs:comment "This is any condition in which the main influencing factor is an antidepressant, a mood-stimulating drug used primarily in the treatment of affective disorders and related conditions." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0000068 a rdfs:Class ;
rdfs:label "body position change, supine to standing" ;
rdfs:subClassOf obo:XCO_0000066 .
obo:XCO_0000734 a rdfs:Class ;
rdfs:label "chemerin-9" ;
rdfs:comment "A potent chemokine-like receptor 1 (CMKLR1) agonist that corresponds to C-terminal of full length human Chemerin (RARRES2), amino acids 149 - 157. Activates Gi/o signaling pathways in vitro; inhibits cAMP production and promotes phospholipase C production, Ca2+ mobilization, and smooth muscle contraction." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000482 .
obo:XCO_0001112 a rdfs:Class ;
rdfs:label "nephrotoxic chemical" ;
rdfs:comment "This is any condition in which the main influencing factor is a nephrotoxic substance that causes injury to the kidney or damages its function." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0000374 a rdfs:Class ;
rdfs:label "axotomy" ;
rdfs:comment "Surgical transection or severing of an axon, the process of a neuron capable of conducting action potentials or self-propagating nerve impulses away from the cell body." ;
rdfs:subClassOf obo:XCO_0001373 .
obo:MESH_D015737 a rdfs:Class .
obo:XCO_0001156 a rdfs:Class ;
rdfs:label "erythromycin" ;
rdfs:comment "This is any condition whose main influencing factor is erythromycin, any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (Streptomyces erythraeus). Erythromycin inhibits protein synthesis by binding to 50S ribosomal subunits, thus interfering with translocation of amino acids during translation and assembly of proteins" ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000532 .
obo:XCO_0001376 a rdfs:Class ;
rdfs:label "experimental spinal cord transection at T10/T11" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental transection of the rat spinal cord at the vertebral level of thoracic 10/11 (T10/11). This procedure involves laminectomy of the tenth vertebra and complete transection of the isolated section of spinal cord." ;
rdfs:subClassOf obo:XCO_0001796 .
obo:XCO_0000744 a rdfs:Class ;
rdfs:label "housing with Haemophilus H21-infected subject" ;
rdfs:comment "A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H21 infection during the time period leading up to the specified housing period. Haemophilus H21 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." ;
rdfs:subClassOf obo:XCO_0000742 .
obo:XCO_0000028 a rdfs:Class ;
rdfs:label "caffeinated drink" ;
rdfs:comment "A drink containing caffeine, one of the methylxanthines soluble in water and alcohol and obtainable from coffee, tea, guarana and mate." ;
rdfs:subClassOf obo:XCO_0000020 .
obo:XCO_0001626 a rdfs:Class ;
rdfs:label "pioglitazone" ;
rdfs:comment "This is any condition in which the main influencing factor is pioglitazone, a member of the class of thiazolidenediones that is an insulin-sensitizing drug, a pantothenate kinase inhibitor, a cardioprotective agent, a PPARgamma agonist, an antidepressant, and a hypoglycemic agent." ;
rdfs:subClassOf obo:XCO_0000407 , obo:XCO_0000523 , obo:XCO_0000561 , obo:XCO_0001196 .
obo:XCO_0001253 a rdfs:Class ;
rdfs:label "Huatan Jiangzhuo decoction" ;
rdfs:comment "This is any condition in which the main influencing factor is Huatan Jiangzhuo decoction, a combination of six traditional Chinese medicines that is used for lipid metabolism-related disorders." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0001043 a rdfs:Class ;
rdfs:label "laminectomy" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of one or more vertebrae. This procedure can serve as sham condition for a spinal cord contusion study." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000954 a rdfs:Class ;
rdfs:label "glucosamine - alendronate" ;
rdfs:comment "This is a condition in which the main influencing factor is an aqueous mix of glucosamine and alendronic acid (the acid form of alendronate), two chemicals used to promote bone health." .
obo:XCO_0001458 a rdfs:Class ;
rdfs:label "intracerebral hemorrhage induced by collagenase injection" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental intracerebral hemorrhage induced by collagenase injection into the cerebrum, a method used to model intracerebral hemorrhage in laboratory animals. Severity of hemorrhage can be controlled by the amount of collagenase injected. For example 0.23 U of bacterial collagenase VII-S injected into rat striatum causes a moderate intracerebral hemorrhage, and 0.6 U of bacterial collagenase VII-S injected into rat striatum causes severe intracerebral hemorrhage." ;
rdfs:subClassOf obo:XCO_0000258 .
obo:XCO_0000278 a rdfs:Class ;
rdfs:label "polycyclic hydrocarbon" ;
rdfs:comment "Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by bonds that may be represented graphically by multiple interlinking circular or triangular forms." ;
rdfs:subClassOf obo:XCO_0000277 .
obo:XCO_0000434 a rdfs:Class ;
rdfs:label "octylphenol" ;
rdfs:comment "Condition in which the main influencing factor is octylphenol, a phenolic ring with an 8-carbon side chain." ;
rdfs:subClassOf obo:XCO_0000239 , obo:XCO_0000396 .
obo:XCO_0001793 a rdfs:Class ;
rdfs:label "experimental spinal cord transection at T2" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimental transection of the rat spinal cord at the vertebral level of thoracic 2 (T2). This procedure involves exposure of the spinal cord at the vertebral level of thoracic1-3 (T1-3) and complete transection of the isolated section of spinal cord at T2." ;
rdfs:subClassOf obo:XCO_0001796 .
obo:XCO_0000017 a rdfs:Class ;
rdfs:label "nephrectomy" ;
rdfs:comment "Surgical removal of kidney." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0001697 a rdfs:Class ;
rdfs:label "gene transfer of the Cre recombinase gene using an adeno-associated virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of the Cre recombinase gene (a bacteriophage P1 enzyme) using an adeno-associated virus vector. Gene transfer into a cell or organism using an adeno-associated virus vector is performed to induce synthesis of the carried gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0001575 .
obo:XCO_0000223 a rdfs:Class ;
rdfs:label "anion channel inhibitor" ;
rdfs:comment "Any chemical substance which decreases or interferes with the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000221 .
obo:XCO_0000057 a rdfs:Class ;
rdfs:label "rebreathed air" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is rebreathed air, air which has been exhaled and breathed in again." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0001666 a rdfs:Class ;
rdfs:label "left renal artery ligation" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical manipulation and left renal artery/branch(es) ligation to achieve partial or total blockage of blood flow from the left renal artery. The left renal artery/branch(es) may be clamped or tied with a suture(s) to achieve blockage of blood flow." ;
rdfs:subClassOf obo:XCO_0000596 .
obo:XCO_0001355 a rdfs:Class ;
rdfs:label "controlled vancomycin hydrochloride content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of vancomycin hydrochloride, the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide used for the treatment of certain bacterial infections, such as infections caused by Clostridium difficile and Staphylococcus aureus." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0001354 .
obo:XCO_0001778 a rdfs:Class ;
rdfs:label "ceric oxide" ;
rdfs:comment "This is any condition in which the main influencing factor is a metal oxide with formula CeO2 (ceric oxide). Ceric oxide is used for polishing glass and as an oxidant and catalyst in organic synthesis. In precllinical trials ceric oxide functions as an agent which promotes anti-inflammatory and antioxidative processes." ;
rdfs:subClassOf obo:XCO_0000505 .
obo:XCO_0001161 a rdfs:Class ;
rdfs:label "fluoxetine" ;
rdfs:comment "This is any condition whose main influencing factor is fluoxetine, the first highly specific serotonin reuptake inhibitor (SSRI). It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants." ;
rdfs:subClassOf obo:XCO_0000561 .
obo:XCO_0001652 a rdfs:Class ;
rdfs:label "SPF rat breed and growth diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a specific-pathogen-free rat breed and growth diet, an SPF diet with 200 g/kg crude protein and 3.44 kcal/g energy content." ;
rdfs:subClassOf obo:XCO_0001651 .
obo:XCO_0000289 a rdfs:Class ;
rdfs:label "R14 peptide of interphotoreceptor retinoid-binding protein" ;
rdfs:comment "A condition in which the major influencing factor is a 23 amino acid peptide (aa 1169-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors." .
obo:XCO_0001414 a rdfs:Class ;
rdfs:label "Ramulus Mori alkaloids" ;
rdfs:comment "This is a condition in which the main influencing factor is Ramulus Mori alkaloids, a group of polyhydroxy alkaloids extracted and isolated from mulberry twig (Morus alba L.). Mulberry twig extract is used in traditional Chinese medicine (TCM) and is used against hyperglycemia and obesity." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000123 a rdfs:Class ;
rdfs:label "sulfonamide" ;
rdfs:comment "A compound containing a sulfonamide functional group. A sulfonamide functional group contains sulfonyl connected to an amine group and has the general structure R-S(=O)2-NH2. Sulfonamide also refers to several classes of drugs which include antimicrobial 'sulfa drugs', anticonvulsants and the sulfonylureas and thiazide diuretics." ;
rdfs:subClassOf obo:XCO_0000342 , obo:XCO_0000950 .
obo:XCO_0000304 a rdfs:Class ;
rdfs:label "bilateral adrenalectomy" ;
rdfs:comment "The surgical excision of both adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." ;
rdfs:subClassOf obo:XCO_0000303 .
obo:XCO_0001108 a rdfs:Class ;
rdfs:label "alginate" ;
rdfs:comment "This is any condition in which the main influencing factor is alginate, a naturally occurring anionic polymer typically obtained from brown seaweed. It is used as a wound dressing to keep the wound area moist." ;
rdfs:subClassOf obo:XCO_0001107 .
obo:XCO_0001738 a rdfs:Class ;
rdfs:label "primaquine" ;
rdfs:comment "This is any condition in which the main influencing factor is primaquine, an N-substituted diamine that is a drug used in the treatment of malaria and Pneumocystis pneumonia. It is an aminoquinoline and an aromatic ether." ;
rdfs:subClassOf obo:XCO_0000799 , obo:XCO_0000850 .
obo:XCO_0000944 a rdfs:Class ;
rdfs:label "controlled alendronate content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of alendronate in which the amount of alendronate consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000475 a rdfs:Class ;
rdfs:label "bacterial pathogen" ;
rdfs:comment "Any condition in which the primary influencing agent is a bacterial pathogen, a disease-causing unicellular prokaryotic microorganism that commonly multiplies by cell division, lacks a nucleus or membrane-bound organelles, and generally has a cell wall." ;
rdfs:subClassOf obo:XCO_0000236 , obo:XCO_0001212 .
obo:XCO_0000835 a rdfs:Class ;
rdfs:label "BT4C cells" ;
rdfs:comment "A condition in which the main influencing factor is a rat malignant glioma cell line." ;
rdfs:subClassOf obo:XCO_0000709 .
obo:XCO_0000609 a rdfs:Class ;
rdfs:label "4-methyl-2-(piperidin-1-yl)-quinoline" ;
rdfs:comment "A potent and selective blocker of TRPC4 channels." ;
rdfs:subClassOf obo:XCO_0000269 .
obo:XCO_0000863 a rdfs:Class ;
rdfs:label "antihypertensive agent" ;
rdfs:comment "This is any condition in which the main influencing factor is a drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0000086 a rdfs:Class ;
rdfs:label "exercise training program" ;
rdfs:comment "A fixed series of exercises or body movements repeated at intervals over a specified period of time as part of a program to improve strength, aerobic capacity or other elements of fitness." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0001703 a rdfs:Class ;
rdfs:label "collapsin response mediator protein 2" ;
rdfs:comment "This is any condition in which the main influencing factor is collapsin response mediator protein 2 (CRMP2), a protein that facilitates neuron guidance, growth and polarity. CRMP2 also plays a role in microtubule assembly and synaptic signaling through interactions with calcium channels." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0001648 a rdfs:Class ;
rdfs:label "human iPSC-derived exosomes" ;
rdfs:comment "This is any condition in which the main influencing factor is human iPSC-derived exosomes. iPSCs (induced pluripotent stem cells) are generated by reprogramming adult somatic cells (typically skin or blood cells) back into an embryonic-like pluripotent state. Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of multivesicular bodies and the plasma membrane." ;
rdfs:subClassOf obo:XCO_0001369 .
obo:XCO_0000112 a rdfs:Class ;
rdfs:label "unilateral nephrectomy" ;
rdfs:comment "Surgical removal of a single kidney." ;
rdfs:subClassOf obo:XCO_0000017 .
obo:XCO_0000039 a rdfs:Class ;
rdfs:label "ionizing radiation exposure" ;
rdfs:comment "The condition of being subjected to transmitted energy composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule." ;
rdfs:subClassOf obo:XCO_0000045 .
obo:XCO_0001601 a rdfs:Class ;
rdfs:label "JNK-IN-5A" ;
rdfs:comment "This is any condition in which the main influencing factor is JNK-IN-5A, an inhibitor of JNK2 (MAPK9/mitogen-activated protein kinase 9), JNK3 (MAPK10/mitogen-activated protein kinase 10) and other mitogen-activated protein kinases." ;
rdfs:subClassOf obo:XCO_0000505 , obo:XCO_0000715 .
obo:XCO_0001076 a rdfs:Class ;
rdfs:label "bilateral ureter ligation" ;
rdfs:comment "This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of both ureters. Bilateral ureter ligation (BUL) is used in experimental animals to create a model of renal failure." ;
rdfs:subClassOf obo:XCO_0001074 .
obo:XCO_0001279 a rdfs:Class ;
rdfs:label "partial bladder outlet obstruction" ;
rdfs:comment "This is any condition in which the main influencing factor is partial bladder outlet obstruction, an experimental constriction of the neck of the urinary bladder to restrict urine flow and model changes that occur in clinical bladder outlet obstruction (BOO). Partial bladder outlet obstruction may be achieved surgically by passing a catheter through the urethra into the bladder, suturing around the neck of the bladder, and removing the catheter." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000006 a rdfs:Class ;
rdfs:label "swimming" ;
rdfs:comment "This is any condition in which the main influencing factor is swimming, the action of a subject moving it's appendages to propel itself through water." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0000472 a rdfs:Class ;
rdfs:label "chrysin" ;
rdfs:comment "Condition in which the main influencing factor is chrysin, a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7." ;
rdfs:subClassOf obo:XCO_0000470 .
obo:XCO_0000396 a rdfs:Class ;
rdfs:label "phenolic/phenol derivative" ;
rdfs:comment "Any organic aromatic compound consisting of at least one phenolic group, that is, a group having one or more hydroxy groups attached to a benzene or other arene ring." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001763 a rdfs:Class ;
rdfs:label "ligustilide" ;
rdfs:comment "This is any condition in which the main influencing factor is ligustilide, the main active ingredient of Angelica roots, which has been used in Chinese medicine to treat menstrual disorders. Ligustilide exerts anti-inflammatory, anti-cancer, neuroprotective and anti-hepatotoxic effects" ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000505 .
obo:XCO_0001436 a rdfs:Class ;
rdfs:label "gastrointestinal bypass" ;
rdfs:comment "This is any condition in which the main influencing factor is gastrointestinal bypass, a type of surgery that either bypasses the stomach or part of the small intestine as a weight loss strategy. Gastrointestinal bypass is also an experimental procedure to study the surgery in model organisms like rats." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000190 a rdfs:Class ;
rdfs:label "angiotensin I" ;
rdfs:comment "The 10 amino acid cleavage product produced by the action of renin on angiotensinogen. Ang I is apparently inactive unless further cleaved by angiotensin-converting enzyme (ACE) into Ang II." ;
rdfs:subClassOf obo:XCO_0000126 .
obo:XCO_0000079 a rdfs:Class ;
rdfs:label "cigarette smoking" ;
rdfs:comment "The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigarette, a small roll of finely cut tobacco enclosed in a wrapper of thin paper." ;
rdfs:subClassOf obo:XCO_0000077 .
obo:XCO_0001440 a rdfs:Class ;
rdfs:label "peptide hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a peptide hydrogel, a hydrogel containing a self-assembling metal ion-chelating peptide (HPGIAQFF) . This peptide hydrogel serves as a control for the peptide hydrogel that contains chelated metal ions. Hydrogel implants are one of many methods used in bone tissue engineering." ;
rdfs:subClassOf obo:XCO_0001439 .
obo:XCO_0001123 a rdfs:Class ;
rdfs:label "alpidem" ;
rdfs:comment "This is any condition in which the main influencing factor is alpidem, a drug formerly used to treat anxiety disorders but its medical use was discontinued due to liver toxicity." ;
rdfs:subClassOf obo:XCO_0001122 .
obo:XCO_0001328 a rdfs:Class ;
rdfs:label "mogroside" ;
rdfs:comment "This is any condition in which the main influencing factor is a mogroside, a glycoside of cucurbitane derivatives found in certain plants, such as monkfruit (S. grosvenorii). Mogrosides are extracted from monkfruit and used in the manufacture of sugar substitutes. Mogrosides have shown some efficacy as anticarcinogens, anti-inflammatory agents, sugar- and lipid-lowering agents." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000407 , obo:XCO_0000505 , obo:XCO_0000850 .
obo:XCO_0001065 a rdfs:Class ;
rdfs:label "scrambled control LNA-modified oligonucleotide" ;
rdfs:comment "This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)modified oligonucleotide with a non-specific scrambled sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0001209 a rdfs:Class ;
rdfs:label "lixisenatide" ;
rdfs:comment "This is any condition in which the main influencing factor is lixisenatide, a 44 amino acid polypeptide and glucagon-like peptide 1 receptor agonist used as an adjunct to diet and exercise for the treatment of adults with type II diabetes." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000193 , obo:XCO_0000407 .
obo:XCO_0001573 a rdfs:Class ;
rdfs:label "subthalamic nucleus stimulation via implanted electrode" ;
rdfs:comment "This is any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to the subthalamic nucleus. This is done with implanted electrode(s)." ;
rdfs:subClassOf obo:XCO_0000027 , obo:XCO_0000520 .
obo:XCO_0001714 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to lactate dehydrogenase A MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to an autoantibody-generating level of lactate dehydrogenase A (LDHA) multiple antigenic peptides (MAPs) that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) LDHA exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001719 .
obo:XCO_0001188 a rdfs:Class ;
rdfs:label "neomycin sulfate" ;
rdfs:comment "This is any condition in which the main influencing factor is neomycin sulfate, the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin is a protein synthesis inhibitor and bacteriacidal agent." .
obo:XCO_0000262 a rdfs:Class ;
rdfs:label "collagen" ;
rdfs:comment "A condition in which the major influencing factor is any of a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility; composed of molecules of tropocollagen." ;
rdfs:subClassOf obo:XCO_0000260 , obo:XCO_0000261 .
obo:XCO_0000405 a rdfs:Class ;
rdfs:label "controlled cisplatin content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of cisplatin consumed by an organism as part of an experiment. Cisplatin is a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001637 a rdfs:Class ;
rdfs:label "gestational maternal exposure to corn oil" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to corn oil. This is a condition typically studied to determine the effect of maternal (F0) corn oil exposure on the F1 offspring. This is typically a control condition for gestational maternal exposure to some chemical agent." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001636 .
obo:XCO_0000572 a rdfs:Class ;
rdfs:label "vancomycin" ;
rdfs:comment "This is any condition in which the main influencing factor is vancomycin, a complex glycopeptide from Streptomyces orientalis. Vancomycin inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0000360 a rdfs:Class ;
rdfs:label "arterial catheter implantation" ;
rdfs:comment "The insertion of a tubular, flexible surgical instrument into an artery to withdraw or introduce fluid. An artery is a vessel in which blood flows away from the heart." ;
rdfs:subClassOf obo:XCO_0000027 , obo:XCO_0000595 .
obo:XCO_0001473 a rdfs:Class ;
rdfs:label "cerebral artery perforation" ;
rdfs:comment "This is any condition in which the main influencing factor is cerebral artery perforation, a controlled surgical procedure which perforates the cerebral artery near the junction of the anterior and middle cerebral arteries with a blunt, nylon monofilament passed through the internal carotid artery. The resultant bleeding is a model of subarachnoid hemorrhage (SAH)." ;
rdfs:subClassOf obo:XCO_0000812 .
obo:XCO_0001677 a rdfs:Class ;
rdfs:label "standard rat chow supplemented with powdered milk and fruit" ;
rdfs:comment "This is any condition in which the main influencing factor is standard rat chow supplemented with powdered milk and fruit. Standard rat chow is a laboratory foodstuff which typically has 380-390 kcal/100 g with 9-10% of calories derived from fat, 70-80% of calories derived from carbohydrate, and 10-15% of calories derived from protein. Additional calories and nutrients would come from dried fruit and milk." ;
rdfs:subClassOf obo:XCO_0000016 .
obo:XCO_0000870 a rdfs:Class ;
rdfs:label "rat adipose-derived stem cells" ;
rdfs:comment "A condition in which the main influencing factor is a rat stem cell, isolated from subcutaneous fat tissue and cultured in vitro. A stem cell is an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions." ;
rdfs:subClassOf obo:XCO_0000851 .
obo:XCO_0001309 a rdfs:Class ;
rdfs:label "methylprednisolone sodium succinate" ;
rdfs:comment "This is any condition in which the main influencing factor is methylprednisolone sodium succinate, the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. Methylprednisolone sodium succinate is converted into active prednisolone in the body, which activates the glucocorticoid receptor." ;
rdfs:subClassOf obo:XCO_0000229 , obo:XCO_0000505 .
obo:XCO_0000445 a rdfs:Class ;
rdfs:label "phosphate buffered saline" ;
rdfs:comment "A relatively standardized solution of sodium chloride to which one or more phosphate salts have been added to maintain a neutral pH. PBS is isotonic, that is, the ionic strength of PBS is close to that inside living cells." ;
rdfs:subClassOf obo:XCO_0000155 , obo:XCO_0000315 .
obo:XCO_0001406 a rdfs:Class ;
rdfs:label "hypobaric chamber" ;
rdfs:comment "This is any condition in which the main influencing factor is a hypobaric chamber, which lowers atmospheric pressure to simulate high altitude." ;
rdfs:subClassOf obo:XCO_0001405 .
obo:XCO_0001619 a rdfs:Class ;
rdfs:label "controlled air diesel exhaust particle content" ;
rdfs:comment "This is any condition in which the main influencing factor is diesel exhaust particles, a component of ambient air pollution. The level of diesel exhaust particles in the air surrounding an organism or breathed by an organism is determined by environmental conditions, work conditions, or controlled as part of an experiment." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0000174 a rdfs:Class ;
rdfs:label "inulin" ;
rdfs:comment "A fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration." ;
rdfs:subClassOf obo:XCO_0000173 .
obo:XCO_0000982 a rdfs:Class ;
rdfs:label "gene transfer using a lentivirus vector" ;
rdfs:comment "This is a condition in which gene transfer has been performed using a lentivirus as the carrier of the genetic material. Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. Lentiviruses are distributed worldwide, and are known to be hosted in apes, cows, goats, horses, cats, and sheep as well as several other mammals." ;
rdfs:subClassOf obo:XCO_0000528 .
obo:XCO_0000290 a rdfs:Class ;
rdfs:label "peripheral myelin protein 2" ;
rdfs:comment "A condition in which the major influencing factor is a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0001425 a rdfs:Class ;
rdfs:label "limbal resection" ;
rdfs:comment "This is any condition in which the main influencing factor is limbal resection, an experimental procedure which surgically removes the border between cornea and sclera of the eye. Limbal resection causes limbal stem cell deficiency (LSCD), which leads to failure of corneal repair, followed by neovascularization, and other pathologic sequelae." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001036 a rdfs:Class ;
rdfs:label "peripheral myelin protein 2 peptide 53-78" ;
rdfs:comment "This is any condition in which the major influencing factor is the peptide (TESPFKNTEISFKLGQEFEETTADNR) representing residues 53 to 78 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins." ;
rdfs:subClassOf obo:XCO_0000290 .
obo:XCO_0001011 a rdfs:Class ;
rdfs:label "penicillin-streptomycin" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is a mixture of penicillin G and streptomycin (penicillin-streptomycin) that is widely used in mammalian cell culture media to prevent bacterial contamination. The solution contains 5,000 units of penicillin G (sodium salt) which acts as the active base, and 5,000 micrograms of streptomycin (sulfate) (base per milliliter), formulated in 0.85% saline." .
obo:XCO_0001134 a rdfs:Class ;
rdfs:label "caffeine" ;
rdfs:comment "This is any condition in which the main influencing factor is caffeine, a methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation." ;
rdfs:subClassOf obo:XCO_0000122 , obo:XCO_0000160 , obo:XCO_0000523 .
obo:XCO_0000625 a rdfs:Class ;
rdfs:label "urethane" ;
rdfs:comment "Antineoplastic agent that is also used as a veterinary anesthetic." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000435 .
obo:XCO_0001595 a rdfs:Class ;
rdfs:label "Mengovirus" ;
rdfs:comment "This is any condition in which the main influencing factor is Mengovirus, a single-stranded RNA virus that belongs to the genus Cardiovirus. The Mengovirus infects vertebrates and is able to suppress the host's immune response by reducing the expression of Nuclear Factor kappa B." ;
rdfs:subClassOf obo:XCO_0000237 .
obo:XCO_0001145 a rdfs:Class ;
rdfs:label "cimetidine" ;
rdfs:comment "This is any condition in which the main influencing factor is cimetidine, an H2-receptor antagonist that inhibits gastric acid secretion, as well as pepsin and gastrin output." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001857 a rdfs:Class ;
rdfs:label "gestational maternal exposure to unpredictable chronic mild stress" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to unpredictable chronic mild stress. This is a condition typically studied to determine the effect of maternal (F0) unpredictable chronic mild stress on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001856 .
obo:XCO_0001101 a rdfs:Class ;
rdfs:label "urinary catheterization" ;
rdfs:comment "This is any condition in which the main influencing factor is urinary catheterization, the insertion of a tune through the urethra into the bladder to allow urine to drain from the bladder for collection or to allow injection of some substance." ;
rdfs:subClassOf obo:XCO_0001100 .
obo:XCO_0001615 a rdfs:Class ;
rdfs:label "aluminum hydroxide" ;
rdfs:comment "This is any condition in which the main influencing factor is aluminium hydroxide, an inorganic salt used as an antacid. Aluminium hydroxide is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0000155 a rdfs:Class ;
rdfs:label "sodium chloride solution" ;
rdfs:comment "A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000254 .
obo:XCO_0001289 a rdfs:Class ;
rdfs:label "tenotomy" ;
rdfs:comment "This is any condition in which the main influencing factor is tenotomy, any process involving transcutaneous or surgical techniques for incision of a tendon to investigate and/or treat a pathological condition. Tenotomy may involve needle puncture, incision, or complete transection of a tendon." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000777 a rdfs:Class ;
rdfs:label "lipoic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is alpha-lipoic acid, a heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position." ;
rdfs:subClassOf obo:XCO_0000776 .
obo:XCO_0000702 a rdfs:Class ;
rdfs:label "thiazoles" ;
rdfs:comment "An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000461 a rdfs:Class ;
rdfs:label "restricted feeding" ;
rdfs:comment "A dietary regimen in which access to food is limited, e.g. to a specified number of hours per day or to a specified part of the light-dark cycle, with or without restrictions in the amount or type of food available when feeding is allowed." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0001640 a rdfs:Class ;
rdfs:label "gestational maternal exposure to dipentyl phthalate" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to dipentyl phthalate. This is a condition typically studied to determine the effect of maternal (F0) dipentyl phthalate use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001639 .
obo:XCO_0000133 a rdfs:Class ;
rdfs:label "antigen" ;
rdfs:comment "A condition in which the major influencing factor is a chemical compound to which the body can mount a specific localized or systemic immune reaction, e.g. a T cell or B cell response." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001235 a rdfs:Class ;
rdfs:label "tetracycline" ;
rdfs:comment "This is any condition in which the main influencing factor is tetracycline, a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. Tetracycline is both an antibacterial and antiprotozoal drug." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000532 , obo:XCO_0000672 .
obo:XCO_0001177 a rdfs:Class ;
rdfs:label "megestrol" ;
rdfs:comment "This is any condition in which the main influencing factor is megestrol, a 3-oxo Delta(4)-steroid that is a progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. Megestrol has also been used in the palliative treatment of breast cancer and as an appetite enhancer in cachectic subjects." ;
rdfs:subClassOf obo:XCO_0000435 .
obo:XCO_0000053 a rdfs:Class ;
rdfs:label "targeted heat exposure" ;
rdfs:comment "An activity or condition involving a high temperature directed toward a particular part of an organism's body." ;
rdfs:subClassOf obo:XCO_0000308 .
obo:XCO_0000546 a rdfs:Class ;
rdfs:label "vitamin analog" ;
rdfs:comment "A condition in which the main influencing factor is a compound with structural and/or functional similarity to a vitamin and can therefore be substituted for the analogous vitamin." ;
rdfs:subClassOf obo:XCO_0000377 .
obo:XCO_0001166 a rdfs:Class ;
rdfs:label "hydroxypropyl methylcellulose" ;
rdfs:comment "This is any condition in which the main influencing factor is hydroxypropyl methylcellulose, a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products." ;
rdfs:subClassOf obo:XCO_0000789 .
obo:XCO_0000000 a rdfs:Class ;
rdfs:label "experimental condition" ;
rdfs:comment "A state of being, an external or environmental factor or a treatment observed or administered prior to or concurrent with an investigative procedure such as an assessment of a morphological or physiological state or property in a single individual or sample or in a group of individuals or samples, especially a state, factor or treatment which has the potential to influence the outcome of such an assessment." .
obo:XCO_0001655 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to sucrose" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to sucrose that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) sucrose use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000432 .
obo:XCO_0001022 a rdfs:Class ;
rdfs:label "flaxseed oil" ;
rdfs:comment "This is any condition in which the main influencing factor is flaxseed oil, an edible oil in demand as a dietary supplement, as a source of α-Linolenic acid, an omega-3 fatty acid." ;
rdfs:subClassOf obo:XCO_0000774 .
obo:XCO_0000737 a rdfs:Class ;
rdfs:label "endotoxin" ;
rdfs:comment "A component of bacterial cells, an endotoxin can be a part of the outer membrane of gram-negative bacteria (lipopolysacharride) or a part or the \"spore\" of gram-positive bacteria (delta endotoxin)." ;
rdfs:subClassOf obo:XCO_0000240 .
obo:XCO_0000728 a rdfs:Class ;
rdfs:label "partial splenectomy" ;
rdfs:comment "Surgical removal of a portion of the spleen, resulting in reduction but not elimination of the physiological functions of the spleen." ;
rdfs:subClassOf obo:XCO_0000727 .
obo:XCO_0000152 a rdfs:Class ;
rdfs:label "drug dose time series" ;
rdfs:comment "The condition of exposing an organism, organ or tissue to a series of increasing or decreasing doses of a drug or other chemical from which a single measurement value is obtained." ;
rdfs:subClassOf obo:XCO_0000151 .
obo:XCO_0000267 a rdfs:Class ;
rdfs:label "peptidoglycan-polysaccharide" ;
rdfs:comment "A condition in which the major influencing factor is a polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network." ;
rdfs:subClassOf obo:XCO_0000133 , obo:XCO_0000173 , obo:XCO_0000261 .
obo:XCO_0001191 a rdfs:Class ;
rdfs:label "nabumetone" ;
rdfs:comment "This is any condition in which the main influencing factor is nabumetone, a prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid. Nabumetone is a methyl ketone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with osteoarthritis and rheumatoid arthritis." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0000892 a rdfs:Class ;
rdfs:label "tumor promoter" ;
rdfs:comment "Tumor promoters are substances that enhance tumorigenicity when administered after a carcinogen. In general, tumor promoters do not possess tumorigenic activity themselves." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0001183 a rdfs:Class ;
rdfs:label "metiamide" ;
rdfs:comment "This is any condition in which the main influencing factor is metiamide, a histamine H2 receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001826 a rdfs:Class ;
rdfs:label "orthopedic implant" ;
rdfs:comment "This is any condition in which the main influencing factor is a surgical procedure in which an orthopedic implant is placed. Orthopedic implants are medical devices intended either to replace a missing bone or joint, or to support a damaged bone." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0000590 a rdfs:Class ;
rdfs:label "icatibant" ;
rdfs:comment "A synthetic decapeptide that is a bradykinin receptor antagonist used for the treatment of hereditary angioedema." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001680 a rdfs:Class ;
rdfs:label "butane-1,3-diol" ;
rdfs:comment "This is any condition in which the main influencing factor is butane-1,3-diol, a butanediol commonly used as a solvent for flavoring agents and is a co-monomer used in certain polyurethane and polyester resins. It is also used as a hypoglycemic agent." ;
rdfs:subClassOf obo:XCO_0000407 , obo:XCO_0001231 .
obo:XCO_0000755 a rdfs:Class ;
rdfs:label "dimethyl sulfoxide" ;
rdfs:comment "This is any condition in which the main influencing factor is dimethyl sulfoxide, a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000505 .
obo:XCO_0000125 a rdfs:Class ;
rdfs:label "hormone" ;
rdfs:comment "A chemical substance which in its endogenous state is produced by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000550 a rdfs:Class ;
rdfs:label "reserpine" ;
rdfs:comment "An experimental condition in which the main influencing factor is reserpine, an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2. Reserpine has been used as both an antihypertensive drug and an antipsychotic drug." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000863 .
obo:XCO_0000547 a rdfs:Class ;
rdfs:label "paricalcitol" ;
rdfs:comment "An experimental condition in which the main influencing factor is paricalcitol, an analog of vitamin D2 used for the prevention and treatment of secondary hyperparathyroidism." ;
rdfs:subClassOf obo:XCO_0000546 .
obo:XCO_0001864 a rdfs:Class ;
rdfs:label "heterotopic heart transplant" ;
rdfs:comment "This is any condition in which the main influencing factor is a heterotopic heart transplant, a surgical procedure in which a heart from a donor organism is implanted into a recipient organism at a site that differs from the site of origin." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0001033 a rdfs:Class ;
rdfs:label "balanced salt solution cell carrying medium" ;
rdfs:comment "This is any condition in which the main influencing factor is a balanced salt solution-based medium for the delivery of a suspension of cells." ;
rdfs:subClassOf obo:XCO_0000154 .
obo:XCO_0001202 a rdfs:Class ;
rdfs:label "penicillin" ;
rdfs:comment "This is any condition in which the main influencing factor is a penicillin, one of a group of β-lactam antibiotics originally obtained from Penicillium molds. Penicillins are widely used for different bacterial infections, though many types of bacteria have developed resistance following extensive use." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0000014 a rdfs:Class ;
rdfs:label "controlled content diet" ;
rdfs:comment "A regimen of solid food in which the amount of one or more elements of the diet are controlled." ;
rdfs:subClassOf obo:XCO_0000019 .
obo:XCO_0001561 a rdfs:Class ;
rdfs:label "6-propyl-2-thiouracil" ;
rdfs:comment "This is any condition in which the main influencing factor is 6-propyl-2-thiouracil (propylthiouracil), a drug used to treat Graves' disease and hyperthyroidism. Propylthiouracil is a thyroid hormone antagonist, a nitric oxide synthase inhibitor, an antioxidant, and an antidote to paracetamol poisoning." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000271 , obo:XCO_0000523 .
obo:XCO_0000815 a rdfs:Class ;
rdfs:label "leg-out partial body irradiation" ;
rdfs:comment "This is a condition/model system that features partial body irradiation (PBI) delivering a high dose of radiation to most of the body, and a small fraction of that dose to one leg of the subject. It allows the study of multi-organ radiation injury while sparing the bone marrow from a lethal dose." ;
rdfs:subClassOf obo:XCO_0000814 .
obo:XCO_0000881 a rdfs:Class ;
rdfs:label "4[N-methyl-14C] iodoantipyrine" ;
rdfs:comment "This is 4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine readily crosses the blood-brain barrier, and has been used to measure total and regional cerebral blood flow in vivo." ;
rdfs:subClassOf obo:XCO_0000171 .
obo:XCO_0001014 a rdfs:Class ;
rdfs:label "transfer of negative control siRNA using a lentiviral vector" ;
rdfs:comment "This is any condition in which the main influencing factor is negative control siRNA delivered with a lentivirus vector. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used." ;
rdfs:subClassOf obo:XCO_0001510 .
obo:XCO_0001579 a rdfs:Class ;
rdfs:label "controlled resveratrol content, CSAA diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a choline‐sufficient, amino acid‐defined (CSAA) diet with controlled resveratrol content." ;
rdfs:subClassOf obo:XCO_0001578 .
obo:XCO_0001492 a rdfs:Class ;
rdfs:label "17alpha-ethynylestradiol" ;
rdfs:comment "This is any condition in which the main influencing factor is 17alpha-ethynylestradiol, a semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in combination with progestogen in oral contraceptives." ;
rdfs:subClassOf obo:XCO_0000092 .
obo:XCO_0000183 a rdfs:Class ;
rdfs:label "controlled exposure to darkness" ;
rdfs:comment "Condition during which visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is removed." ;
rdfs:subClassOf obo:XCO_0000181 .
obo:XCO_0000453 a rdfs:Class ;
rdfs:label "controlled butter content diet" ;
rdfs:comment "This is a solid diet in which the amount of butter is maintained at a specified level. Butter is a soft yellowish or whitish emulsion of milk fat, water and air, churned from milk or cream and processed for use in cooking and as a food." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000466 a rdfs:Class ;
rdfs:label "controlled ex vivo artery perfusion pressure" ;
rdfs:comment "A condition in which the pressure, or force per area, exerted by a perfusate against the walls of an artery after removal from the body but while the tissue is still viable, is regulated or maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000465 .
obo:XCO_0001313 a rdfs:Class ;
rdfs:label "inferior alveolar nerve transection" ;
rdfs:comment "This is any condition in which the main influencing factor is transection of the inferior alveolar nerve, a model of a peripheral nerve injury. The inferior alveolar nerve (IAN) is a branch of the mandibular nerve in the lower jaw. The inferior alveolar nerve branches into the mylohyoid nerve and the mental nerve." ;
rdfs:subClassOf obo:XCO_0001373 .
obo:XCO_0001246 a rdfs:Class ;
rdfs:label "trimethobenzamide" ;
rdfs:comment "This is any condition in which the main influencing factor is trimethobenzamide, a drug used to prevent nausea and vomiting in humans." ;
rdfs:subClassOf obo:XCO_0001245 .
obo:XCO_0001719 a rdfs:Class ;
rdfs:label "lactate dehydrogenase A MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is lactate dehydrogenase A (LDHA) presented as multiple antigenic peptides (MAPs), which are four copies of the same peptide epitope synthesized on a lysine-based core (MAPs-4 system)." ;
rdfs:subClassOf obo:XCO_0001713 .
obo:XCO_0000965 a rdfs:Class ;
rdfs:label "controlled in vitro cell condition" ;
rdfs:comment "This is any experimental condition in which cells derived from a multicellular organism are cultured and experimentally manipulated or regulated, for example through drug treatment or nutrient availability, in an artificial environment outside the living body." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001054 a rdfs:Class ;
rdfs:label "Qingda granule" ;
rdfs:comment "This is any condition in which the main influencing factor is Qingda granule, derived from Qingxuan Jiangya Decoction (QXJYD), which has been in usage for a long time as a traditional Chinese medicine formula." ;
rdfs:subClassOf obo:XCO_0000863 .
obo:XCO_0001333 a rdfs:Class ;
rdfs:label "maternal exposure to oxycodone during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to oxycodone during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) oxycodone use/exposure during the postnatal, preweaning period on the F1 offspring." .
obo:XCO_0001837 a rdfs:Class ;
rdfs:label "loperamide hydrochloride" ;
rdfs:comment "This is any condition in which the main influencing factor is loperamide hydrochloride, an opioid agonist used for the treatment of diarrhea caused by gastroenteritis or inflammatory bowel disease." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0000657 .
obo:XCO_0000853 a rdfs:Class ;
rdfs:label "rat serum from subject bearing a B48-14 IgE-producing hybridoma" ;
rdfs:comment "Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected B48-14 IgE-producing hybridoma. The serum is essentially antiserum containing B48-14 IgE, which are directed against a S. mansoni adult worm antigen." ;
rdfs:subClassOf obo:XCO_0000769 .
obo:XCO_0000064 a rdfs:Class ;
rdfs:label "cycling, non-stationary" ;
rdfs:comment "The action of propelling a two wheeled vehicle by the movement of a person's legs." ;
rdfs:subClassOf obo:XCO_0000062 .
obo:XCO_0000212 a rdfs:Class ;
rdfs:label "controlled copper content diet" ;
rdfs:comment "A regimen of solid food in which the amount of copper consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000920 .
obo:XCO_0001007 a rdfs:Class ;
rdfs:label "transfer of negative control shRNA using a lentivirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is negative control shRNA delivered with a lentivirus vector. Negative control shRNA is an shRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental shRNA used." ;
rdfs:subClassOf obo:XCO_0001537 .
obo:XCO_0001322 a rdfs:Class ;
rdfs:label "3D printed β‐TCP scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a 3D printed β‐TCP scaffold, a tissue scaffold made of a printable, bioceramic material (mainly β‐tricalcium phosphate/β‐TCP). β-tricalcium phosphate (β-TCP) is one the most used and potent synthetic bone graft substitutes. β-TCP has the beneficial properties of biocompatibility, osteoconductivity, osteoinductivity, and biodegradability." ;
rdfs:subClassOf obo:XCO_0001319 .
obo:XCO_0000640 a rdfs:Class ;
rdfs:label "controlled in situ myocardial condition" ;
rdfs:comment "Any experimental condition in which the internal or external environment of the myocardial system is altered." ;
rdfs:subClassOf obo:XCO_0000166 .
obo:XCO_0000494 a rdfs:Class ;
rdfs:label "postmenopause" ;
rdfs:comment "The physiological period after the natural cessation of estrus or menstruation cycles in an aging female mammal." ;
rdfs:subClassOf obo:XCO_0000411 .
obo:XCO_0001568 a rdfs:Class ;
rdfs:label "gestational maternal exposure to 6-propyl-2-thiouracil" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to 6-propyl-2-thiouracil. This is a condition typically studied to determine the effect of maternal (F0) 6-propyl-2-thiouracil use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001567 .
obo:XCO_0000621 a rdfs:Class ;
rdfs:label "tritiated verapamil" ;
rdfs:comment "Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker" ;
rdfs:subClassOf obo:XCO_0000171 , obo:XCO_0000616 .
obo:XCO_0001047 a rdfs:Class ;
rdfs:label "Tet3 gapmer antisense oligonucleotide" ;
rdfs:comment "This is any condition in which the main influencing factor is a Tet3 gapmer (Tet3-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence." ;
rdfs:subClassOf obo:XCO_0000234 .
obo:XCO_0000444 a rdfs:Class ;
rdfs:label "controlled dexamethasone content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of dexamethasone (DEX) consumed by an organism as part of an experiment. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001257 a rdfs:Class ;
rdfs:label "trovafloxacin" ;
rdfs:comment "This is any condition in which the main influencing factor is trovafloxacin, a broad spectrum antibiotic more effective against Gram-positive bacteria than Gram-negative bacteria. Trovafloxacin exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA by blocking the activity of DNA gyrase and topoisomerase IV." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000523 .
obo:XCO_0000517 a rdfs:Class ;
rdfs:label "anti-transforming growth factor beta antibody" ;
rdfs:comment "A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with any or all of the transforming growth factor beta cytokines." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0000780 a rdfs:Class ;
rdfs:label "liposomes" ;
rdfs:comment "This is any condition in which the main influencing factor is liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000101 a rdfs:Class ;
rdfs:label "vehicle control condition" ;
rdfs:comment "A treatment used as a control in which a saline or other solution is administered in the same manner as the experimental solution minus the key element of the experimental solution." ;
rdfs:subClassOf obo:XCO_0000099 .
obo:XCO_0001081 a rdfs:Class ;
rdfs:label "SBFI-103" ;
rdfs:comment "This is any condition in which the main influencing factor is SBFI-103, a selective FABP5 inhibitor. It is an experimental drug for treatment of cancer and osteoarthritis." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0000557 a rdfs:Class ;
rdfs:label "glucosamine" ;
rdfs:comment "Glucosamine, commonly used as a treatment for osteoarthritis, is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis." ;
rdfs:subClassOf obo:XCO_0000556 .
obo:XCO_0000654 a rdfs:Class ;
rdfs:label "kynurenate" ;
rdfs:comment "Kynurenate is a product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Kynurenate is an endogenous antagonist of the ionotropic glutamate receptors." ;
rdfs:subClassOf obo:XCO_0000653 .
obo:XCO_0000438 a rdfs:Class ;
rdfs:label "candesartan" ;
rdfs:comment "A condition in which the main influencing factor is candesartan, the angiotensin II receptor 1 (AT1) antagonist which exhibits antihypertensive effects in animal models." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000536 .
obo:XCO_0000363 a rdfs:Class ;
rdfs:label "eukaryotic pathogen" ;
rdfs:comment "A condition in which the main influencing factor is a single-celled or multicellular organism that has the capacity to cause disease, and the cell(s) of which individually have a true nucleus, that is, one that is bounded by a nuclear membrane, contains one or more chromosomes, and divides by mitosis." ;
rdfs:subClassOf obo:XCO_0000236 .
obo:XCO_0001853 a rdfs:Class ;
rdfs:label "gestational maternal exposure to controlled ethanol content liquid diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to a controlled ethanol content liquid diet. This is a condition typically studied to determine the effect of a maternal (F0) controlled ethanol content liquid diet on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001852 .
obo:XCO_0001469 a rdfs:Class ;
rdfs:label "iron trichloride" ;
rdfs:comment "This is any condition in which the main influencing factor is iron trichloride, a iron coordination entity that has the formula FeCl3(H2O)x." ;
rdfs:subClassOf obo:XCO_0001549 .
obo:XCO_0000938 a rdfs:Class ;
rdfs:label "bovine serum albumin" ;
rdfs:comment "This is a serum albumin protein derived from cow blood. It is used as an enzyme-stabilizing agent, a blocking reagent, etc. for laboratory experiments." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0000605 a rdfs:Class ;
rdfs:label "aflatoxin B1" ;
rdfs:comment "An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11." ;
rdfs:subClassOf obo:XCO_0000240 .
obo:XCO_0001696 a rdfs:Class ;
rdfs:label "methionine/choline deficient diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a methionine/choline deficient diet. This diet is used to study induction of non-alcoholic steatohepatitis (NASH) in experimental animal models." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001563 a rdfs:Class ;
rdfs:label "zymosan" ;
rdfs:comment "This is any condition in which the main influencing factor is zymosan, a protein-carbohydrate complex derived from yeast cell walls. Zymosan induces experimental sterile inflammation and activates macrophages by binding to TLR2 and Dectin-1 receptors. Joint injection of zymosan induces arthritis in experimental animals to create a model of chronic proliferative arthritis." ;
rdfs:subClassOf obo:XCO_0000261 .
obo:XCO_0001092 a rdfs:Class ;
rdfs:label "sciatic nerve crush" ;
rdfs:comment "This is any condition in which the main influencing factor is an experimentally controlled sciatic nerve crush, which is used as a model of sciatic neuropathy, Wallerian degeneration, and axonal regeneration." ;
rdfs:subClassOf obo:XCO_0001814 .
obo:XCO_0000040 a rdfs:Class ;
rdfs:label "gamma ray exposure" ;
rdfs:comment "The condition of being subjected to high frequency, high energy electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Gamma radiation is traditionally considered to have wavelengths less than 0.01 nm and are generally emitted by nuclei rather than by electrons." ;
rdfs:subClassOf obo:XCO_0000039 .
obo:XCO_0001213 a rdfs:Class ;
rdfs:label "Parabacteroides johnsonii" ;
rdfs:comment "This is any condition in which the main influencing factor is Parabacteroides johnsonii, an anaerobic, gram-negative bacillus of the CFB group of bacteria. P. johnsonii is an anaerobe isolated from human fecal matter." ;
rdfs:subClassOf obo:XCO_0001212 .
obo:XCO_0001771 a rdfs:Class ;
rdfs:label "controlled air naphthalene content" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled air naphthalene content surrounding an organism or breathed by the organism as part of an experiment. Naphthalene is an aromatic hydrocarbon comprising two fused benzene rings. Naphthalene is the main ingredient of traditional mothballs." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0000208 a rdfs:Class ;
rdfs:label "2-acetamidofluorene" ;
rdfs:comment "A condition in which the main influencing factor is 2-acetamidofluorene (2-AAF) an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. 2-AAF and a number of its metabolites are both carcinogenic and mutagenic." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000205 .
obo:XCO_0000712 a rdfs:Class ;
rdfs:label "vasopressin receptor agonist" ;
rdfs:comment "Any drug which binds to vasopressin receptors and triggers a response." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0001232 a rdfs:Class ;
rdfs:label "emulsifier" ;
rdfs:comment "This is any condition in which the main influencing factor is an emulsifier, a surface-active agent (such as a soap) promoting the formation and stabilization of an emulsion (a fine dispersion of minute droplets of one liquid in another in which it is not soluble)." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000392 a rdfs:Class ;
rdfs:label "nucleoside/nucleotide" ;
rdfs:comment "A condition in which the main influencing factor is any of various compounds consisting of a purine or pyrimidine base and a sugar, usually ribose or deoxyribose, with (nucleotide) or without (nucleoside) one or more phosphate groups." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000556 a rdfs:Class ;
rdfs:label "amino monosaccharide" ;
rdfs:comment "Any amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group." ;
rdfs:subClassOf obo:XCO_0000274 .
obo:XCO_0000629 a rdfs:Class ;
rdfs:label "carbenoxolone" ;
rdfs:comment "An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity." ;
rdfs:subClassOf obo:XCO_0000279 .
obo:XCO_0001159 a rdfs:Class ;
rdfs:label "felbamate" ;
rdfs:comment "This is any condition whose main influencing factor is felbamate, a PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA receptors. Felbamate is used as an anticonvulsant, primarily for the treatment of seizures in severe refractory epilepsy." ;
rdfs:subClassOf obo:XCO_0000950 .
obo:XCO_0000234 a rdfs:Class ;
rdfs:label "deoxyribonucleic acid" ;
rdfs:comment "A long, polymeric chain of alternating phosphate and deoxyribose units with the bases adenine, guanine, cytosine, and thymine bonded to the deoxyribose. DNA can be single stranded or double stranded, that is, composed of either a single polymer or a pair of antiparallel polymers joined by hydrogen bonding between complementary bases." ;
rdfs:subClassOf obo:XCO_0000232 .
obo:XCO_0000536 a rdfs:Class ;
rdfs:label "angiotensin II receptor antagonist" ;
rdfs:comment "This is any condition in which the main influencing factor is an angiotensin II receptor antagonist, an agent that blocks angiotensin II receptors and is used to treat high blood pressure and heart failure." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0000863 .
obo:XCO_0001003 a rdfs:Class ;
rdfs:label "magnetic field" ;
rdfs:comment "This is any condition in which the main influencing factor is a magnetic field, a vector field in the neighborhood of a magnet, electric current, or changing electric field in which magnetic forces are observable." ;
rdfs:subClassOf obo:XCO_0000965 .
obo:XCO_0000144 a rdfs:Class ;
rdfs:label "neurotransmitter" ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000352 a rdfs:Class ;
rdfs:label "myelin" ;
rdfs:comment "A condition in which the major influencing factor is myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers." ;
rdfs:subClassOf obo:XCO_0000133 .
obo:XCO_0001584 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to dimethyl sulfoxide" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to dimethyl sulfoxide that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) dimethyl sulfoxide use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000101 , obo:XCO_0000755 .
obo:XCO_0001832 a rdfs:Class ;
rdfs:label "hippocampal stimulation via implanted electrode array" ;
rdfs:comment "This is any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to a specific area of the hippocampus. This is done with implanted electrode(s)." ;
rdfs:subClassOf obo:XCO_0000027 , obo:XCO_0000520 .
obo:XCO_0000025 a rdfs:Class ;
rdfs:label "controlled fat content diet" ;
rdfs:comment "A regimen of solid food in which the amount of fat consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000194 a rdfs:Class ;
rdfs:label "antibody" ;
rdfs:comment "An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that induced its synthesis and with molecules containing structures similar to that antigen. An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0000535 a rdfs:Class ;
rdfs:label "lisinopril" ;
rdfs:comment "A condition in which the main influencing factor is lisinopril, an antihypertensive competitive inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0001604 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to controlled fat content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to controlled fat content diet that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) controlled fat content diet on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000025 .
obo:XCO_0000166 a rdfs:Class ;
rdfs:label "controlled in situ organ condition" ;
rdfs:comment "Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000245 a rdfs:Class ;
rdfs:label "insulin" ;
rdfs:comment "A protein hormone formed from proinsulin in the beta cells of the pancreatic islets of Langerhans. The major fuel-regulating hormone, it is secreted into the blood in response to a rise in concentration of blood glucose or amino acids. Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis." ;
rdfs:subClassOf obo:XCO_0000228 .
obo:XCO_0001221 a rdfs:Class ;
rdfs:label "medium-chain triglyceride-containing ketogenic diet, KR 1.4" ;
rdfs:comment "This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), KR 1.4, a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight of approximately 1.4. A diet with a higher KR ratio delivers more fat than a diet with a lower KR." ;
rdfs:subClassOf obo:XCO_0001219 .
obo:XCO_0000256 a rdfs:Class ;
rdfs:label "isoproterenol" ;
rdfs:comment "A drug which is structurally similar to epinephrine and that binds to beta-adrenergic receptors to produce a physiologic reaction similar to or the same as that of epinephrine." ;
rdfs:subClassOf obo:XCO_0000665 .
obo:XCO_0000141 a rdfs:Class ;
rdfs:label "vasoconstrictor" ;
rdfs:comment "A condition in which the main influencing factor is a molecule that acts to constrict or reduce the interior diameter of blood vessels." ;
rdfs:subClassOf obo:XCO_0000139 .
obo:XCO_0001488 a rdfs:Class ;
rdfs:label "myclobutanil" ;
rdfs:comment "This is any condition in which the main influencing factor is myclobutanil, a widely-used agricultural triazole fungicide. Myclobutanil may cause developmental toxicity and male reproductive toxicity." ;
rdfs:subClassOf obo:XCO_0001489 .
obo:XCO_0001644 a rdfs:Class ;
rdfs:label "controlled beta-aminopropionitrile content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a solid diet in which the amount of beta-aminopropionitrile is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000643 a rdfs:Class ;
rdfs:label "controlled exposure to a foster mother of a different strain within the same species." ;
rdfs:subClassOf obo:XCO_0000491 .
obo:XCO_0000528 a rdfs:Class ;
rdfs:label "gene transfer" ;
rdfs:comment "This is any condition in which copies of an exogenous gene have been transiently or stably inserted into a living cell or organism in order to induce synthesis of that gene's product or to block synthesis of some gene product." ;
rdfs:subClassOf obo:XCO_0000527 .
obo:XCO_0000651 a rdfs:Class ;
rdfs:label "E4177" ;
rdfs:comment "A condition in which the main influencing factor is E4177, an agent that blocks one or more angiotensin II receptors." ;
rdfs:subClassOf obo:XCO_0000536 .
obo:XCO_0000976 a rdfs:Class ;
rdfs:label "trichlorethylene" ;
rdfs:comment "This is a chloroethene that is ethene substituted by chlorides at positions 1, 1 and 2. It is a highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000276 .
obo:XCO_0000449 a rdfs:Class ;
rdfs:label "diestrus" ;
rdfs:comment "A period of sexual quiescence that intervenes between two periods of estrus in females of non-primate mammalian species between. In general during diestrus blood levels of estrogens are minimal, progesterone levels are high and the physiological state in the uterus is most conducive for implantation and growth of the developing fetus." .
obo:XCO_0001350 a rdfs:Class ;
rdfs:label "diallyl trisulfide" ;
rdfs:comment "This is any condition in which the main influencing factor is diallyl trisulfide, an organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. Diallyl trisulfide is a component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium. Diallyl trisulfide has multiple medicinal effects." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000160 , obo:XCO_0000271 , obo:XCO_0000435 , obo:XCO_0000482 , obo:XCO_0000505 , obo:XCO_0000680 .
obo:XCO_0000993 a rdfs:Class ;
rdfs:label "controlled humidity" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is a controlled level of moisture in the air provided to an organism, ex vivo tissue, or cultured cells." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0000568 a rdfs:Class ;
rdfs:label "hydralazine hydrochloride" ;
rdfs:comment "A vasodilator and an antioxidant. It relaxes arteries and inhibits membrane-bound enzymes that form reactive oxygen species, such as superoxides." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000551 .
obo:XCO_0001305 a rdfs:Class ;
rdfs:label "pulmonary artery occlusion" ;
rdfs:comment "This is any condition in which the main influencing factor is pulmonary artery occlusion, a clinical or experimental surgical procedure which restricts the amount of blood flow to the lung via the pulmonary artery." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0000257 a rdfs:Class ;
rdfs:label "controlled hydrogen ion content drinking water" ;
rdfs:comment "A drink made up of water containing a specified amount of hydrogen ions, the chemical element with atomic number 1 that have lost one electron forming a cation with a charge of +1, for consumption by an organism in an experiment. Adjusting the amount of hydrogen ions adjusts the acidity, i.e. the pH of the drinking water." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001789 a rdfs:Class ;
rdfs:label "(7R,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is (7R,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid, a dihydroxydocosahexaenoic acid in which the two hydroxy substituents are located at the 7R- and 14S-positions. It functions as a hepatoprotective agent and an anti-inflammatory agent." ;
rdfs:subClassOf obo:XCO_0000323 , obo:XCO_0000505 .
obo:XCO_0001868 a rdfs:Class ;
rdfs:label "hindlimb unloading" ;
rdfs:comment "This is any condition in which the main influencing factor is hindlimb unloading, a model used to simulate weightlessness or disuse in quadrupeds by elevating and suspending the hindquarters to avoid weightbearing. The model allows for normal weightbearing by the forelimbs and results in a shift of bodily fluids toward the head." ;
rdfs:subClassOf obo:XCO_0000081 .
obo:XCO_0001130 a rdfs:Class ;
rdfs:label "amprenavir" ;
rdfs:comment "This is any condition in which the main influencing factor is amprenavir, a protease inhibitor designed to treat HIV infections. Amprenavir has been replaced by fosamprenavir, a prodrug of amprenavir." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0000657 .
obo:XCO_0000723 a rdfs:Class ;
rdfs:label "butanol" ;
rdfs:comment "A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes." ;
rdfs:subClassOf obo:XCO_0000324 .
obo:XCO_0001302 a rdfs:Class ;
rdfs:label "dapagliflozin" ;
rdfs:comment "This is any condition in which the main influencing factor is dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for managing diabetes mellitus type 2." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000407 .
obo:XCO_0001872 a rdfs:Class ;
rdfs:label "median nerve excisional wound" ;
rdfs:comment "This is any condition in which the main influencing factor is trauma caused by the act of cutting out all or part of the median nerve, a nerve of the arm that originates from the brachial plexus and is formed from parts of the medial and lateral cords of the brachial plexus, and continues down the arm to enter the forearm with the brachial artery." ;
rdfs:subClassOf obo:XCO_0000373 , obo:XCO_0001836 .
obo:XCO_0001339 a rdfs:Class ;
rdfs:label "human serum" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is human serum. Human serum is used in tissue engineering, transplantation and cell therapy applications, for the expansion of mesenchymal stem cells (MSC) from adipose tissue or bone marrow, ex vivo expansion of peripheral blood cells, etc." ;
rdfs:subClassOf obo:XCO_0000965 .
obo:XCO_0000103 a rdfs:Class ;
rdfs:label "glucose solution" ;
rdfs:comment "A mixture in which molecules of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level." .
obo:XCO_0000217 a rdfs:Class ;
rdfs:label "cation channel activator" ;
rdfs:comment "Any chemical substance which increases the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000216 .
obo:XCO_0000846 a rdfs:Class ;
rdfs:label "Hu-S102-129" ;
rdfs:comment "Any condition in which the main influencing factor is a 28 amino acid polypeptide representing residues 102 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon." ;
rdfs:subClassOf obo:XCO_0000828 .
obo:XCO_0001574 a rdfs:Class ;
rdfs:label "subthalamic nucleus implanted electrode sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is an subthalamic nucleus implanted electrode sham procedure, which follows the same surgical process as a subthalamic nucleus implanted electrode procedure, but no electrical stimulus is delivered." ;
rdfs:subClassOf obo:XCO_0000367 .
obo:XCO_0001324 a rdfs:Class ;
rdfs:label "H1-hESC-derived hNPCs" ;
rdfs:comment "This is any condition in which the main influencing factor is an injection or infusion of human neural progenitor cells derived from the H1 human embryonic stem cell line (H1-hESC)." ;
rdfs:subClassOf obo:XCO_0001032 .
obo:XCO_0000748 a rdfs:Class ;
rdfs:label "protease inhibitor" ;
rdfs:comment "Any condition in which the main influencing factor is a substance which decreases or interferes with the activity of a protease, any of numerous enzymes that hydrolyze proteins." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001194 a rdfs:Class ;
rdfs:label "NB-360" ;
rdfs:comment "This is any condition in which the main influencing factor is NB-360, a dual BACE1/BACE2 (beta-secretase 1/beta-secretase 2) inhibitor that stops the progression of amyloid-β (Aβ) deposition and reduces neuroinflammation." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001268 a rdfs:Class ;
rdfs:label "tail clip" ;
rdfs:comment "This is any condition in which the main influencing factor is a tail clip procedure, a procedure done in the process of collecting blood from a laboratory animal. The subject is usually lightly restrained by the handler or by a mechancal device, while a few millimeters is cut off the end of the tail." .
obo:XCO_0000486 a rdfs:Class ;
rdfs:label "Haemophilus influenzae 86-028NP C5 mutant" ;
rdfs:comment "A condition in which the primary influencing factor is the C5 mutant of the 86-028NP strain of Haemophilus influenzae." ;
rdfs:subClassOf obo:XCO_0000481 .
obo:XCO_0001224 a rdfs:Class ;
rdfs:label "sudoxicam" ;
rdfs:comment "This is any condition in which the main influencing factor is sudoxicam, a benzothiazine derivative and non-steroidal anti-inflammatory drug. Sudoxicam also has anti-edema and antipyretic activity." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0001316 a rdfs:Class ;
rdfs:label "methamphetamine" ;
rdfs:comment "This is any condition in which the main influencing factor is methamphetamine, a member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000327 a rdfs:Class ;
rdfs:label "controlled quinine content drinking water" ;
rdfs:comment "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of quinine, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Quinine is a bitter alkaloid of cinchona that has antimalarial, analgesic, antipyretic, mild oxytocic, cardiac depressant, and sclerosing properties, and that decreases the excitability of the motor end plate." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000121 a rdfs:Class ;
rdfs:label "NG-nitroarginine methyl ester" ;
rdfs:comment "A basic amino acid, commonly known as L-NAME, used as a non-selective inhibitor of nitric oxide synthase." ;
rdfs:subClassOf obo:XCO_0000119 , obo:XCO_0000523 .
obo:XCO_0000504 a rdfs:Class ;
rdfs:label "coronal plane rotational acceleration of the head" ;
rdfs:comment "A condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at an increasing velocity." ;
rdfs:subClassOf obo:XCO_0000503 .
obo:XCO_0000906 a rdfs:Class ;
rdfs:label "ovalbumin" ;
rdfs:comment "This is any condition in which the main influencing factor is ovalbumin, the main protein found in egg white. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0001498 a rdfs:Class ;
rdfs:label "gestational maternal exposure to sodium carboxymethylcellulose" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to sodium carboxymethylcellulose. This is a condition typically studied to determine the effect of maternal (F0) sodium carboxymethylcellulose use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001495 .
obo:XCO_0001443 a rdfs:Class ;
rdfs:label "medial collateral ligament transection" ;
rdfs:comment "This is any condition in which the main influencing factor is medial collateral ligament transection, a process involving a surgical technique for complete transection of the medial collateral ligament to investigate ligament healing in an experimental animal model." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0001730 a rdfs:Class ;
rdfs:label "gestational maternal exposure to gene transfer of the human CYP11A1 gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to gene transfer of the human CYP11A1 gene using an adenovirus vector. This is a condition typically studied to determine the effect of a maternal (F0) exposure to gene transfer of the human CYP11A1 gene using an adenovirus vector on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001729 .
obo:XCO_0000091 a rdfs:Class ;
rdfs:label "steroid" ;
rdfs:comment "Any condition in which the main influencing factor is a naturally occurring compound or related synthetic analog with a molecular structure based on the cyclopenta[a]phenanthrene carbon skeleton, that is, a phenanthrene, to the a side of which a three-carbon fragment is fused. According to the definition at the Chemical Entities of Biological Importance (ChEBI) database, 'By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred' which expands the class to include molecules based on but not containing the cannonical arrangement of four fused cycloalkane rings." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000386 a rdfs:Class ;
rdfs:label "collagenase-solubilized glomerular basement membrane" ;
rdfs:comment "A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells." ;
rdfs:subClassOf obo:XCO_0000385 .
obo:XCO_0000402 a rdfs:Class ;
rdfs:label "habituation to experimental apparatus" ;
rdfs:comment "A condition in which an experimental subject is exposed to an experimental apparatus in order to habituate the individual to the apparatus. Habituation is the gradual decrease in behavioral responses to a particular stimulus or environment after repeated exposures have proven to be of no consequence." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001570 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to controlled air E-cigarette aerosol content" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to controlled air E-cigarette/nicotine aerosol content that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) controlled air E-cigarette/nicotine (~2.4%) aerosol content exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." .
obo:XCO_0001098 a rdfs:Class ;
rdfs:label "crystalline silica" ;
rdfs:comment "This is any condition in which the main influencing factor is crystalline silica. Silica is synonymous with silicon dioxide (SiO2) and commonly found in nature as sand. Silica exists mainly as crystalline silica (mostly in the form of quartz)." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000137 a rdfs:Class ;
rdfs:label "FAPGG" ;
rdfs:comment "An oligopeptide substrate for continuous spectrophotometric assay of angiotensin converting enzyme (ACE) which hydrolyzes FAPGG to furylacryloylphenylalanine (FAP) and glycylglycine with a resulting decrease in absorbance at 340 nm." ;
rdfs:subClassOf obo:XCO_0000136 .
obo:XCO_0000975 a rdfs:Class ;
rdfs:label "carbon tetrachloride" ;
rdfs:comment "This is any condition in which the main influencing factor is carbon tetrachloride, a chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups. It is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds." ;
rdfs:subClassOf obo:XCO_0000239 , obo:XCO_0001231 .
obo:XCO_0001532 a rdfs:Class ;
rdfs:label "Masquelet surgery" ;
rdfs:comment "This is any condition in which the main influencing factor is use of the Masquelet surgical technique, a surgical procedure used to reconstruct bone defects, particularly those that are large or infected. This technique involves placement of a polymethyl methacrylate (PMMA) cement spacer in a bone defect to allow growth of a vascularized membrane that promotes bone regeneration. A second stage in the method involves removing the spacer after membrane growth and replacing it with bone graft." .
obo:XCO_0001459 a rdfs:Class ;
rdfs:label "ethoxysanguinarine" ;
rdfs:comment "This is any condition in which the main influencing factor is ethoxysanguinarine, an activator of AMP-Activated Protein Kinase (AMPK). It possesses antibacterial and antiviral activities and offers therapeutic benefits for the treatment of respiratory syndrome virus-induced cytopathic effects." .
obo:XCO_0000868 a rdfs:Class ;
rdfs:label "incision repair with conventional suture" ;
rdfs:comment "A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures. Surgical sutures are specially made thread that comes in different sizes and different material." ;
rdfs:subClassOf obo:XCO_0000867 .
obo:XCO_0000414 a rdfs:Class ;
rdfs:label "lactation" ;
rdfs:comment "The process of synthesis and secretion of milk from the mammary glands in the nourishment of offspring." ;
rdfs:subClassOf obo:XCO_0000411 .
obo:XCO_0000177 a rdfs:Class ;
rdfs:label "thrombin" ;
rdfs:comment "An enzyme in blood formed from prothrombin that facilitates blood clotting by reacting with fibrinogen to form fibrin, as well as participating in additional steps in the coagulation pathway." ;
rdfs:subClassOf obo:XCO_0000176 .
obo:XCO_0000897 a rdfs:Class ;
rdfs:label "capsaicin" ;
rdfs:comment "This is an alkylamide found in some peppers that acts as an agonist at TRPV1 cation channels." ;
rdfs:subClassOf obo:XCO_0000217 .
obo:XCO_0001639 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to dipentyl phthalate" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to dipentyl phthalate that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) dipentyl phthalate use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001638 .
obo:XCO_0001263 a rdfs:Class ;
rdfs:label "zafirlukast" ;
rdfs:comment "This is any condition in which the main influencing factor is zafirlukast, a leukotriene receptor antagonist (LTRA) and cytochrome P450 2C9 (CYP2C9) inhibitor." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0000523 .
obo:XCO_0000296 a rdfs:Class ;
rdfs:label "running on inclined treadmill" ;
rdfs:comment "The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount." ;
rdfs:subClassOf obo:XCO_0000005 .
obo:XCO_0000660 a rdfs:Class ;
rdfs:label "controlled nisoldipine content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of nisoldipine in which the amount of nisoldipine consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000964 a rdfs:Class ;
rdfs:label "perfluorooctanoic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is perfluorooctanoic acid, a fluoroalkanoic acid." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000757 , obo:XCO_0001559 .
obo:XCO_0001438 a rdfs:Class ;
rdfs:label "duodenal-jejunal bypass sham surgery" ;
rdfs:comment "This is any condition in which the main influencing factor is duodenal-jejunal bypass sham surgery, a surgical procedure which follows the same surgical process as duodenal-jejunal bypass surgery, but all intestinal transections are reanastomosed without any tissue repositioning." ;
rdfs:subClassOf obo:XCO_0001437 .
obo:XCO_0001206 a rdfs:Class ;
rdfs:label "probenecid" ;
rdfs:comment "This is any condition in which the main influencing factor is probenecid, the prototypical uricosuric agent, a drug that promotes the excretion of uric acid. Probenecid inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Because probenecid reduces the renal tubular excretion of other drugs, it has been used as an adjunct to antibacterial therapy." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0000921 a rdfs:Class ;
rdfs:label "controlled zinc content diet" ;
rdfs:comment "A regimen of solid food in which the amount of zinc is controlled." ;
rdfs:subClassOf obo:XCO_0000920 .
obo:XCO_0000726 a rdfs:Class ;
rdfs:label "hesperidin" ;
rdfs:comment "A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage." ;
rdfs:subClassOf obo:XCO_0000603 .
obo:XCO_0001770 a rdfs:Class ;
rdfs:label "polyethyloxated castor oil" ;
rdfs:comment "This is any condition in which the main influencing factor is polyethyloxated castor oil, a nonionic surfactant derived from the reaction of castor oil with ethylene oxide. It is used as an emulsifier and solubilizer for water-insoluble drugs." ;
rdfs:subClassOf obo:XCO_0000757 , obo:XCO_0001232 .
obo:XCO_0000020 a rdfs:Class ;
rdfs:label "drink" ;
rdfs:comment "A liquid consumed by an organism." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0001386 a rdfs:Class ;
rdfs:label "gestational maternal exposure to saline" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to saline. This is a vehicle control condition typically studied to determine any effect of maternal (F0) saline (vehicle) use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001385 .
obo:XCO_0000062 a rdfs:Class ;
rdfs:label "cycling" ;
rdfs:comment "The action of riding on a stationary or moving vehicle with wheels that is propelled by the movement of a person's legs." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0000241 a rdfs:Class ;
rdfs:label "streptozotocin" ;
rdfs:comment "This is any condition in which the main influencing factor is streptozotocin, a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. STZ can be used to treat pancreatic islet cell cancers and to model type 1 diabetes mellitus in animals via destruction of the insulin-producing beta cells of the islets of Langerhans." ;
rdfs:subClassOf obo:XCO_0000240 , obo:XCO_0000435 , obo:XCO_0000482 , obo:XCO_0000885 .
obo:XCO_0001820 a rdfs:Class ;
rdfs:label "Rnf20-gRNA transfer using a plasmid vector" ;
rdfs:comment "This is any condition in which the main influencing factor is plasmid transfer of Rnf20-gRNA targeting the promoter of the Rnf20 gene, a ubiquitin E3 ligase for histone H2B. gRNA (guide RNA) is a short synthetic RNA, used in CRISPR gene manipulation, composed of a scaffold sequence necessary for Cas enzyme binding and a short nucleotide spacer that specifies the genomic target to be modified." ;
rdfs:subClassOf obo:XCO_0001819 .
obo:XCO_0001716 a rdfs:Class ;
rdfs:label "lactate dehydrogenase B" ;
rdfs:comment "This is any condition in which the main influencing factor is lactate dehydrogenase B (LDHB), a subunit of an enzyme with L-lactate dehydrogenase (NAD+) activity that is involved in a post-glycolytic process." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0001018 a rdfs:Class ;
rdfs:label "WIN 55,212-2" ;
rdfs:comment "This is an organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000269 .
obo:XCO_0001828 a rdfs:Class ;
rdfs:label "interleukin-1 beta" ;
rdfs:comment "This is any condition in which the main influencing factor is interleukin-1 beta, a pro-inflammatory cytokine produced as a proprotein, which is processed to its active form by caspase 1." ;
rdfs:subClassOf obo:XCO_0000783 .
obo:XCO_0001058 a rdfs:Class ;
rdfs:label "controlled corticosterone content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000837 a rdfs:Class ;
rdfs:label "gene transfer of the 15-LO-1 gene using an adenovirus vector" ;
rdfs:comment "A condition in which the 15-Lipoxygenase-1 (15-LO-1) gene has been transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0001860 a rdfs:Class ;
rdfs:label "nerve graft" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a nerve graft. This is a surgical procedure intended to restore lost or impaired nerve function." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0000711 a rdfs:Class ;
rdfs:label "taurolidine" ;
rdfs:comment "An antimicrobial that is also being studied as a treatment for cancer. It is derived from the endogenous amino acid taurine." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000483 .
obo:XCO_0000172 a rdfs:Class ;
rdfs:label "carbohydrate" ;
rdfs:comment "Any of a group of organic compounds that includes sugars, starches, celluloses, and gums and serves as a major energy source in the diet of animals." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001741 a rdfs:Class ;
rdfs:label "gestational maternal exposure to dicyclohexyl phthalate" ;
rdfs:comment "This is any condition in which the main influencing factor is gestational maternal exposure to dicyclohexyl phthalate. This is a condition typically studied to determine the effect of maternal (F0) exposure to dicyclohexyl phthalate on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001740 .
obo:XCO_0001231 a rdfs:Class ;
rdfs:label "solvent" ;
rdfs:comment "This is any condition in which the main influencing factor is a solvent, a liquid that can dissolve other substances (solutes) without any change in their chemical composition." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000462 a rdfs:Class ;
rdfs:label "light phase of controlled light/dark cycle" ;
rdfs:comment "The portion of a controlled light/dark cycle in which the subject is exposed to ambient light (that is, during which the room is lit). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth." ;
rdfs:subClassOf obo:XCO_0000459 .
obo:XCO_0001190 a rdfs:Class ;
rdfs:label "amphotericin B" ;
rdfs:comment "This is any condition in which the main influencing factor is amphotericin B, macrolide antifungal and antiprotozoal antibiotic produced by Streptomyces nodosus." ;
rdfs:subClassOf obo:XCO_0001489 .
obo:XCO_0000633 a rdfs:Class ;
rdfs:label "hydrocortisone" ;
rdfs:comment "Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone. It is produced in many animals mainly by the zona fasciculata of the adrenal cortex within the adrenal gland." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0001196 a rdfs:Class ;
rdfs:label "ethers" ;
rdfs:comment "This is any condition in which the main influencing factor is an ether, any of a class of compounds that contain an ether group, an oxygen atom connected to two alkyl or aryl groups. They have the general formula R−O−R′, where R and R′ represent the alkyl or aryl groups." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000357 a rdfs:Class ;
rdfs:label "walking on inclined treadmill" ;
rdfs:comment "The action of ambulation on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount." ;
rdfs:subClassOf obo:XCO_0000004 .
obo:XCO_0000752 a rdfs:Class ;
rdfs:label "right carotid artery occlusion" ;
rdfs:comment "A surgical manipulation causing blockage of the right common carotid artery, or a branch (internal or external) of the right common carotid artery." ;
rdfs:subClassOf obo:XCO_0000751 .
obo:XCO_0000784 a rdfs:Class ;
rdfs:label "interleukin-2" ;
rdfs:comment "This is any condition in which the main influencing factor is interleukin-2, a cytokine made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system." ;
rdfs:subClassOf obo:XCO_0000783 .
obo:XCO_0001781 a rdfs:Class ;
rdfs:label "diaphragm denervation" ;
rdfs:comment "This is any condition in which the main influencing factor is the transection or resection of one or both of the phrenic nerves. The phrenic nerves convey impulses between the central nervous system and the diaphragm." ;
rdfs:subClassOf obo:XCO_0000373 .
obo:XCO_0000148 a rdfs:Class ;
rdfs:label "controlled oxygen content physiological salt solution perfusate" ;
rdfs:comment "A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of oxygen gas, the tasteless, odorless, colorless gas with atomic number 8 essential for aerobic respiration, dissolved in it." ;
rdfs:subClassOf obo:XCO_0000147 .
obo:XCO_0001270 a rdfs:Class ;
rdfs:label "forced cold water swimming" ;
rdfs:comment "This is any condition in which the main influencing factor is forced swimming in cold water, a situation in which the subject (typically a laboratory rodent), inside a water-filled cylinder, must swim to survive." ;
rdfs:subClassOf obo:XCO_0001269 .
obo:XCO_0000483 a rdfs:Class ;
rdfs:label "antibacterial agent" ;
rdfs:comment "This is any condition in which the main influencing factor is an antibacterial agent, a substance that kills or slows the growth of bacteria, unicellular prokaryotic microorganisms that commonly multiply by cell division, lack a nucleus or membrane-bound organelles, and generally have a cell wall." ;
rdfs:subClassOf obo:XCO_0000482 .
obo:XCO_0001220 a rdfs:Class ;
rdfs:label "medium-chain triglyceride-containing ketogenic diet, KR 2.0" ;
rdfs:comment "This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), KR 2.0, a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight of approximately 2.0. A diet with a higher KR ratio delivers more fat than a diet with a lower KR." ;
rdfs:subClassOf obo:XCO_0001219 .
obo:XCO_0000252 a rdfs:Class ;
rdfs:label "tolbutamide" ;
rdfs:comment "A first generation potassium channel blocker and sulfonylurea oral hypoglycemic drug which stimulates the secretion of insulin by the pancreas." ;
rdfs:subClassOf obo:XCO_0000225 , obo:XCO_0000251 , obo:XCO_0000407 .
obo:XCO_0001476 a rdfs:Class ;
rdfs:label "8-aminoguanine" ;
rdfs:comment "This is any condition in which the main influencing factor is 8-aminoguanine, a naturally occurring purine that is produced from precursors containing 8-nitroguanine. 8-aminoguanine has effects on urine volume, sodium excretion, glucose excretion, and the metabolome influencing inflammation in the context of metabolic syndrome." ;
rdfs:subClassOf obo:XCO_0000505 , obo:XCO_0000863 .
obo:XCO_0001329 a rdfs:Class ;
rdfs:label "opioid analgesic" ;
rdfs:comment "This is any condition in which the main influencing factor is an opioid analgesic. Opioids (synthetic or semisynthetic) and opiates (related natural alkaloids) make up this class of medication used in the management and treatment of pain." ;
rdfs:subClassOf obo:XCO_0000106 .
obo:XCO_0001597 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to valproate" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to valproate that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) valproate use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001258 .
obo:XCO_0000425 a rdfs:Class ;
rdfs:label "lactotransferrin" ;
rdfs:comment "A condition in which the main influencing factor is lactotransferrin, a multifunctional protein of the transferrin family which is a major iron-binding protein in milk and body secretions, and has antimicrobial activity." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0001448 a rdfs:Class ;
rdfs:label "fractional CO2 laser ablation of liver" ;
rdfs:comment "This is a condition in which the main influencing factor is fractional CO2 laser ablation of liver, an experimental procedure involving the creation of microinjuries in a restricted surface area of liver. This use of fractional ablation is an adaptation of a technique of dermal scar treatment. Access to liver surface requires laparotomy." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000569 a rdfs:Class ;
rdfs:label "controlled hydralazine hydrochloride content drinking water" ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001842 a rdfs:Class ;
rdfs:label "Ostruthin" ;
rdfs:comment "This is any condition in which the main influencing factor is Ostruthin, a coumarin with roles as a metabolite, a TWIK-related potassium channel (TREK) agonist, and an antimicrobial agent." ;
rdfs:subClassOf obo:XCO_0000217 , obo:XCO_0000483 .
obo:XCO_0001623 a rdfs:Class ;
rdfs:label "Traditional Chinese Medicine" ;
rdfs:comment "This is any condition in which the main influencing factor is Traditional Chinese Medicine (TCM), a medical system that has been used for thousands of years to prevent, diagnose, and treat disease. Traditional Chinese medicine includes acupuncture, diet, herbal therapy, meditation, physical exercise, and massage." ;
rdfs:subClassOf obo:XCO_0000850 .
obo:XCO_0000204 a rdfs:Class ;
rdfs:label "testosterone" ;
rdfs:comment "The principal androgenic, that is, male sex hormone. Responsible for regulation of gonadotropic secretion, spermatogenesis and control of other male characteristics." ;
rdfs:subClassOf obo:XCO_0000229 .
obo:XCO_0000610 a rdfs:Class ;
rdfs:label "morphine" ;
rdfs:comment "This is any condition in which the main influencing factor is morphine, the main alkaloid of opium that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy)." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0001329 .
obo:XCO_0001217 a rdfs:Class ;
rdfs:label "controlled glucose content reverse osmosis-filtered drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of reverse osmosis-filtered water and a specified amount of glucose consumed by an organism as part of an experiment. Glucose is one of three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion." ;
rdfs:subClassOf obo:XCO_0001216 .
obo:XCO_0001465 a rdfs:Class ;
rdfs:label "ochratoxin A" ;
rdfs:comment "This is any condition in which the main influencing factor is ochratoxin A, a phenylalanine derivative that is a nephrotoxic, carcinogenic mycotoxin. Ochratoxin A is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000222 , obo:XCO_0001112 .
obo:XCO_0000108 a rdfs:Class ;
rdfs:label "pentobarbital, sodium" ;
rdfs:comment "Sodium salt of pentobarbital, a short to intermediate acting barbiturate used as a sedative and hypnotic." ;
rdfs:subClassOf obo:XCO_0000107 .
obo:XCO_0001581 a rdfs:Class ;
rdfs:label "controlled pterostilbene content, CSAA diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a choline‐sufficient, amino acid‐defined (CSAA) diet with controlled pterostilbene content." ;
rdfs:subClassOf obo:XCO_0001578 .
obo:XCO_0000339 a rdfs:Class ;
rdfs:label "titanium dioxide nanoparticle" ;
rdfs:comment "This is any condition in which the main influencing factor is a nanoparticle with a size between 1 and 100 nanometers composed of titanium dioxide. Titanium dioxide is a white insoluble powder that is the naturally occurring oxide of titanium, chemical formula TiO2, i.e. composed of one atom of titanium, the strong, low-density, highly corrosion-resistant metallic element with atomic number 22, and two atoms of oxygen, the highly reactive chemical element with atomic number 8 that is essential for plant and animal respiration and is required for nearly all combustion." ;
rdfs:subClassOf obo:XCO_0000338 .
obo:XCO_0000849 a rdfs:Class ;
rdfs:label "positively charged liposome-entrapped doxorubicin" ;
rdfs:comment "An experimental condition in which the main influencing factor is positively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication." ;
rdfs:subClassOf obo:XCO_0000539 , obo:XCO_0000781 .
obo:XCO_0001100 a rdfs:Class ;
rdfs:label "physical manipulation" ;
rdfs:comment "This is any condition in which the main influencing factor is the use of manual or mechanical, non-surgical means to aid a patient or experimental animal in performing some biological activity for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation. This may or may not require the use of tools or devices." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000830 a rdfs:Class ;
rdfs:label "artificial cerebrospinal fluid" ;
rdfs:comment "Any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF), a buffer solution prepared with a composition representative of cerebrospinal fluid. It is used experimentally for rat brain microdialysis experiments, the culture of hippocampal tissue slices, or irrigation treatment of brain trauma lesions to supply oxygen, maintain osmolarity, and to buffer pH at biological levels." ;
rdfs:subClassOf obo:XCO_0000154 .
obo:XCO_0000379 a rdfs:Class ;
rdfs:label "alpha-tocopherol" ;
rdfs:comment "A condition in which the main influencing factor is the most active form of vitamin E, a 6-hydroxychroman derivative (chromene) with methyl groups in position 2,5,7, and 8 and a phytyl side chain attached at carbon 2. May be described chemically as 2R-(4'R,8'R)-5,7,8-trimethyltocol, with the term tocol indicating the 2-ring structure (benzopyran-6-ol) basic to all vitamin E compounds." .
obo:XCO_0000188 a rdfs:Class ;
rdfs:label "darodipine" ;
rdfs:comment "Calcium channel blocker." ;
rdfs:subClassOf obo:XCO_0000269 .
obo:XCO_0000558 a rdfs:Class ;
rdfs:label "taxifolin" ;
rdfs:comment "Taxifolin is a flavanonol and a non-steroidal anti-inflammatory agent." ;
rdfs:subClassOf obo:XCO_0000470 , obo:XCO_0000506 .
obo:XCO_0000638 a rdfs:Class ;
rdfs:label "Capsazepine" ;
rdfs:comment "A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001661 a rdfs:Class ;
rdfs:label "rabeprazole" ;
rdfs:comment "This is any condition in which the main influencing factor is rabeprazole, a benzimidazole that has a role as a H(+)/K(+)-exchanging ATPase inhibitor (proton pump inhibitor). Rabeprazole is used as an anti-ulcer drug." ;
rdfs:subClassOf obo:XCO_0000577 .
obo:XCO_0001629 a rdfs:Class ;
rdfs:label "TRULI" ;
rdfs:comment "This is any condition in which the main influencing factor is TRULI, a potent and ATP-competitive inhibitor of Lats1 (large tumor suppressor kinase 1) and Lats2 (large tumor suppressor kinase 2) kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues by inhibiting phosphorylation of YES1-associated transcriptional regulator (YAP1)." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000970 .
obo:XCO_0000031 a rdfs:Class ;
rdfs:label "controlled calcium content diet" ;
rdfs:comment "A regimen of solid food in which the amount of calcium consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000823 a rdfs:Class ;
rdfs:label "peanut oil" ;
rdfs:comment "Any condition in which the main influencing factor is peanut oil, a colorless to yellow fatty nondrying oil that is obtained from peanuts and is used chiefly as a salad oil, in margarine, in soap, and as a vehicle in pharmaceutical preparations and cosmetics." ;
rdfs:subClassOf obo:XCO_0000774 .
obo:XCO_0001148 a rdfs:Class ;
rdfs:label "clopidogrel" ;
rdfs:comment "This is any condition whose main influencing factor is clopidogrel, a ticlopidine analog and platelet P2Y12 receptor antagonist that inhibits adenosine diphosphate-mediated platelet aggregation. It is used to prevent thromboembolism in patients with arterial occlusive diseases." ;
rdfs:subClassOf obo:XCO_0001238 .
obo:XCO_0000383 a rdfs:Class ;
rdfs:label "controlled losartan content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of losartan consumed by an organism as part of an experiment. Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) receptor antagonist, reducing the end organ responses to angiotensin II." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000774 a rdfs:Class ;
rdfs:label "oil" ;
rdfs:comment "Any condition in which the main influencing factor is any of numerous unctuous combustible substances that are liquid or can be liquefied easily on warming, are soluble in ether but not in water, and leave a greasy stain on paper or cloth." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001592 a rdfs:Class ;
rdfs:label "porcine dECM hydrogel implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a porcine, decellularized, extracellular matrix (dECM) hydrogel scaffold, a tissue scaffold made of decellularized, extracellular matrix from porcine kidney. dECM hydrogel has been utilized for experimental nerve regeneration, spinal cord injury repair, and resected kidney defect repair." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0001521 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to controlled air oxygen content" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to controlled air oxygen content. This is a condition typically studied to determine the effect of maternal (F0) controlled air oxygen content exposure on the F1 offspring." .
obo:XCO_0000826 a rdfs:Class ;
rdfs:label "rat anti-Hu-MBP T cell line" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with human myelin basic protein." ;
rdfs:subClassOf obo:XCO_0000763 .
obo:XCO_0000343 a rdfs:Class ;
rdfs:label "nitrosourea" ;
rdfs:comment "Any condition in which the main influencing factor is a chemical having a nitroso (R-N=O) and a urea moiety. A urea moiety consists of two -NH2 groups joined by a carbonyl (C=O) group." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001315 a rdfs:Class ;
rdfs:label "Tianhe Zhuifeng Gao" ;
rdfs:comment "This is any condition in which the main influencing factor is Tianhe Zhuifeng Gao, a complex mixture of herbal and other medicinal ingredients. Tianhe Zhuifeng Gao is an external analgesic used as a plaster formulation or a liquid extract." ;
rdfs:subClassOf obo:XCO_0000106 .
obo:XCO_0001163 a rdfs:Class ;
rdfs:label "hydroxyzine" ;
rdfs:comment "This is any condition whose main influencing factor is hydroxyzine, a histamine H1 receptor antagonist that is an anxiolytic drug, a dermatologic drug, an antipruritic drug and an anticoronaviral agent." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0001122 .
obo:XCO_0000649 a rdfs:Class ;
rdfs:label "trans-4-hydroxy-L-proline" ;
rdfs:comment "This is any condition in which the main influencing factor is trans-4-hydroxy-L-proline, an optically active form of 4-hydroxyproline having L-trans-configuration. Trans-4-hydroxy-L-proline is a human, mouse, and plant metabolite that is also used to cause disease in a rat model of urolithiasis." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0001456 a rdfs:Class ;
rdfs:label "psilocybin" ;
rdfs:comment "This is any condition in which the main influencing factor is psilocybin, a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. Psilocybin is quickly converted by the body to psilocin, a hallucinogen." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0000543 a rdfs:Class ;
rdfs:label "vitamin D" ;
rdfs:comment "This is any condition in which the main influencing factor is one or more closely related forms (vitamers) of vitamin D, a group of fat-soluble vitamins (when ingested from dietary sources) and/or hormones (when produced by the skin in response to ultraviolet radiation). Vitamin D is involved in intestinal absorption of calcium, magnesium and phosphate, and in calcium homeostasis and metabolism." ;
rdfs:subClassOf obo:XCO_0000377 .
obo:XCO_0000715 a rdfs:Class ;
rdfs:label "mitogen-activated protein kinase inhibitor" ;
rdfs:comment "This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a mitogen-activated protein kinase." ;
rdfs:subClassOf obo:XCO_0000970 .
obo:XCO_0000495 a rdfs:Class ;
rdfs:label "neurotoxic substance" ;
rdfs:comment "A condition in which the main influencing factor is any substance that is poisonous or destructive to nerve cells or tissue, or that can be metabolized into a substance that is destructive to nerve cells or tissue." ;
rdfs:subClassOf obo:XCO_0000239 .
obo:XCO_0000368 a rdfs:Class ;
rdfs:label "autoimmune disease-inducing chemical" ;
rdfs:comment "Any condition in which the main influencing factor is a chemical that causes an anti-self reaction by the immune system of the treated individual." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0000928 a rdfs:Class ;
rdfs:label "ColonLYTELY" ;
rdfs:comment "This is a colonoscopy prep composed of 5.9% Macrogol 3350 (polyethylene glycol) and electrolytes." .
obo:XCO_0001212 a rdfs:Class ;
rdfs:label "bacteria" ;
rdfs:comment "This is any condition in which the main influencing factor is bacteria, any of a domain of chiefly round, spiral, or rod-shaped single-celled prokaryotic microorganisms that are represented in most ecological niches on earth." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0000864 a rdfs:Class ;
rdfs:label "hepatic portal vein occlusion" ;
rdfs:comment "A condition involving surgical manipulation causing blockage of one or more branches of the hepatic portal vein, a vein that transports nutrients from the digestive tract to the liver." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0001628 a rdfs:Class ;
rdfs:label "sham gene transfer using an empty adenovirus vector" ;
rdfs:comment "This is a condition in which an empty adenovirus vector (transiently or stably) has been transferred into a cell or organism. This condition is used as a control for an adenovirus transfer of a specific gene." ;
rdfs:subClassOf obo:XCO_0000099 , obo:XCO_0000529 .
obo:XCO_0001174 a rdfs:Class ;
rdfs:label "lumiracoxib" ;
rdfs:comment "This is any condition whose main influencing factor is lumiracoxib, a highly selective cyclooxygenase 2 inhibitor used for the treatment of osteoarthritis until it was withdrawn from use due to concerns of hepatotoxicity." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000506 .
obo:XCO_0001397 a rdfs:Class ;
rdfs:label "transfer of negative control siRNA using jetPEI transfection reagent" ;
rdfs:comment "This is any condition in which the main influencing factor is negative control siRNA delivered with jetPEI transfection reagent. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences. JetPEI transfection reagent is a linear polyethylenimine derivative, designed for high throughput screening (HTS) in adherent and suspension cell cultures." ;
rdfs:subClassOf obo:XCO_0001510 .
obo:XCO_0001445 a rdfs:Class ;
rdfs:label "TNF-primed human BM-MSC exosomes" ;
rdfs:comment "This is any condition in which the main influencing factor is exosomes from human, bone marrow-derived, mesenchymal stromal cells which have been primed with cytokine TNF-alpha." ;
rdfs:subClassOf obo:XCO_0001369 .
obo:XCO_0001087 a rdfs:Class ;
rdfs:label "limited bedding and nesting" ;
rdfs:comment "This is any condition in which the main influencing factor is limited bedding and nesting, a housing condition designed to create a model of early life adversity. The minimum bedding/nesting may be as little as a paper towel in a plain, unadorned cage." ;
rdfs:subClassOf obo:XCO_0000033 .
obo:XCO_0000875 a rdfs:Class ;
rdfs:label "isolated lung perfusion" ;
rdfs:comment "An experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle." ;
rdfs:subClassOf obo:XCO_0000874 .
obo:XCO_0000346 a rdfs:Class ;
rdfs:label "N-methyl-N-nitrosourea" ;
rdfs:comment "Any condition in which the main influencing factor is a chemical with three major moieties, a methyl group (a one-carbon alkyl substituent with chemical formula -CH3), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000205 , obo:XCO_0000343 .
obo:XCO_0000332 a rdfs:Class ;
rdfs:label "controlled RU28362 content drinking water" ;
rdfs:comment "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of RU28362, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001320 a rdfs:Class ;
rdfs:label "3D printed GelMA scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a 3D printed gelatin-methacryloyl (GelMA) scaffold, a tissue scaffold made of the bioprintable, natural polymer hydrogel gelatin methacryloyl. GelMA has been widely utilized for diverse tissue engineering applications." ;
rdfs:subClassOf obo:XCO_0001319 .
obo:XCO_0000161 a rdfs:Class ;
rdfs:label "losartan" ;
rdfs:comment "This is any condition whose main influencing factor is losartan, an angiotensin II receptor antagonist and vasodilator which consists of a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position. Losartan also has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000536 .
obo:XCO_0001249 a rdfs:Class ;
rdfs:label "Poloxamer 407" ;
rdfs:comment "This is any condition in which the main influencing factor is Poloxamer 407 (P407), a nonionic triblock copolymer with a polyoxypropylene molecular mass of 4000 g/mol and a 70% polyoxyethylene content. P407 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products." ;
rdfs:subClassOf obo:XCO_0001248 .
obo:XCO_0001185 a rdfs:Class ;
rdfs:label "MK-0773" ;
rdfs:comment "This is any condition in which the main influencing factor is MK-0773, an experimental drug that was under development for the treatment of sarcopenia. MK-0773 is a 4-azasteroid and agonist of the androgen receptor (SARM, selective androgen receptor modulator)." ;
rdfs:subClassOf obo:XCO_0000091 , obo:XCO_0000135 .
obo:XCO_0001634 a rdfs:Class ;
rdfs:label "gene transfer of the Gja1 gene S282A variant using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the S282A variant of the gap junction protein, alpha 1 gene (Gja1) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0001201 a rdfs:Class ;
rdfs:label "paroxetine" ;
rdfs:comment "This is any condition in which the main influencing factor is paroxetine, a serotonin uptake inhibitor that is effective in the treatment of depression and anxiety." ;
rdfs:subClassOf obo:XCO_0000561 , obo:XCO_0001122 .
obo:XCO_0001618 a rdfs:Class ;
rdfs:label "filtered air" ;
rdfs:comment "This is any condition in which the main influencing factor is filtered air, which is air cleared of particulate matter or other pollutants. This is a control condition for the study of various air pollutants." ;
rdfs:subClassOf obo:XCO_0000009 , obo:XCO_0000099 .
obo:XCO_0000852 a rdfs:Class ;
rdfs:label "human periodontal ligament-derived stem cells" ;
rdfs:comment "A condition in which the main influencing factor is human periodontal ligament-derived stem cells, which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal and other tissue type regeneration. The advantages of the use of dental stem cells include their easy isolation by noninvasive routine clinical procedures, their broad differentiation potential, minimal ethical concerns, and that they may enable autologous transplantation." ;
rdfs:subClassOf obo:XCO_0001393 .
obo:XCO_0000571 a rdfs:Class ;
rdfs:label "controlled tolvaptan content diet" ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000841 a rdfs:Class ;
rdfs:label "GSK-812" ;
rdfs:comment "An experimental condition in which the main influencing factor is GSK-812, a potent neuroprotectant that can induce GDNF in normal and diseased retina, and antagonizes multiple receptors, including D2 and D3 receptors, and 5-HT2A, 2C, and 5-HT6 receptors.." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001286 a rdfs:Class ;
rdfs:label "von Frey monofilament stimulus" ;
rdfs:comment "This is any condition in which the main influencing factor is a Von Frey monofilament stimulus, usually encountered in a Von Frey assay, which is used to evaluate mechanical allodynia in laboratory rodents. The von Frey test, which may be manual or electronic, uses von Frey monofilaments (hair or fibers), which are small pieces of nylon rod, approximately 50 mm in length, and of varying diameters, to test a rodent's sensitivity to punctate mechanical pressure on the plantar surface of a rear paw. Von Frey filaments are able to deliver force in the range of 0.08 to 2940 mN." ;
rdfs:subClassOf obo:XCO_0000052 .
obo:XCO_0001029 a rdfs:Class ;
rdfs:label "gene transfer of the Rpl10a gene and EYFP gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the Rpl10a (ribosomal protein L10A) gene and enhanced yellow fluorescent protein (EYFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0001027 , obo:XCO_0001028 .
obo:XCO_0001779 a rdfs:Class ;
rdfs:label "ceric oxide nanoparticle" ;
rdfs:comment "This is any condition in which the main influencing factor is a particle with a size between 1 and 100 nanometers composed of ceric oxide (CeO2). These particles can switch between Ce3+ and Ce4+ oxidation states, giving them catalytic, self-regenerating free radical-scavenging activity." ;
rdfs:subClassOf obo:XCO_0000338 , obo:XCO_0001778 .
obo:XCO_0001137 a rdfs:Class ;
rdfs:label "carisoprodol" ;
rdfs:comment "This is any condition in which the main influencing factor is carisoprodol, a carbamate ester which is a centrally acting skeletal muscle relaxant whose mechanism of action may be related to its sedative actions. Carisoprodol is used for the relief of discomfort associated with acute, painful musculoskeletal conditions." ;
rdfs:subClassOf obo:XCO_0000511 .
obo:XCO_0001297 a rdfs:Class ;
rdfs:label "autologous blood transfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is autologous blood transfusion, the intravenous reinfusion of blood or blood components to the same individual from whom they were taken." ;
rdfs:subClassOf obo:XCO_0001296 .
obo:XCO_0001607 a rdfs:Class ;
rdfs:label "gestational maternal exposure to controlled fat content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to a controlled fat content diet. This is a condition typically studied to determine the effect of a maternal (F0) controlled fat content diet on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001604 .
obo:XCO_0001234 a rdfs:Class ;
rdfs:label "telithromycin" ;
rdfs:comment "This is any condition in which the main influencing factor is telithromycin, a semi-synthetic erythromycin derivative which belongs to a new chemical class of antibiotics called ketolides. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000532 .
obo:XCO_0001511 a rdfs:Class ;
rdfs:label "transfer of rat Oprm-1 shRNA using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of rat Oprm-1 (opioid receptor, mu 1) shRNA. Oprm-1 is the mu opioid receptor (MOR). The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0000598 a rdfs:Class ;
rdfs:label "thoracic aorta constriction" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical narrowing of the lumen of the thoracic aorta. The thoracic aorta consists of the ascending aorta, the aortic arch, and the descending thoracic aorta." ;
rdfs:subClassOf obo:XCO_0000596 .
obo:XCO_0001773 a rdfs:Class ;
rdfs:label "controlled air carbon black nanoparticle content" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled air carbon black nanoparticle content surrounding an organism or breathed by the organism as part of an experiment. Carbon black is an elemental carbon in the form of virtually pure colloidal particles that are produced by incomplete combustion or thermal decomposition of gaseous or liquid hydrocarbons under controlled conditions. Nanoparticles have a particle size of less than 100 nm in any direction." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0000473 a rdfs:Class ;
rdfs:label "naringenin" ;
rdfs:comment "Condition in which the main influencing factor is naringenin, a trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 6 and 4'. Naringenin is the predominant flavanone in grapefruit and has demonstrated inhibitory activity against the CYP1A2 cytochrome P450 isoform." ;
rdfs:subClassOf obo:XCO_0000470 .
obo:XCO_0000886 a rdfs:Class ;
rdfs:label "epilepsy-inducing chemical" ;
rdfs:comment "A condition in which the main influencing factor is substance that causes seizures in experimental animals, initiated by the injection of a drug." ;
rdfs:subClassOf obo:XCO_0000259 .
obo:XCO_0000560 a rdfs:Class ;
rdfs:label "controlled melatonin content diet" ;
rdfs:comment "A solid diet in which the amount of melatonin is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000559 .
obo:XCO_0001336 a rdfs:Class ;
rdfs:label "enrofloxacin" ;
rdfs:comment "This is any condition in which the main influencing factor is enrofloxacin, an antibiotic and antineoplastic agent from the fluoroquinolone family used in veterinary medicine." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000483 .
obo:XCO_0000371 a rdfs:Class ;
rdfs:label "Trichinella spiralis larvae" ;
rdfs:comment "A condition in which the main influencing factor is the infective larvae of the nematode parasite Trichinella spiralis." ;
rdfs:subClassOf obo:XCO_0000370 .
obo:XCO_0001353 a rdfs:Class ;
rdfs:label "controlled metronidazole content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of metronidazole, a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. Metronidazole is frequently used to treat gastrointestinal infections and parasitic infections such as trichomoniasis, giardiasis, and amebiasis. The antiparasitic of properties of metronidazole set it apart from many other antibacterial drugs, allowing it to treat a wider variety of infections." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0001189 .
obo:XCO_0001786 a rdfs:Class ;
rdfs:label "lateral fluid percussion injury sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a lateral fluid percussion injury sham procedure, which follows the same surgical process as a lateral fluid percussion injury without applying a brief fluid pressure pulse onto the intact dura after performing a craniectomy on the head of the subject." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0001500 a rdfs:Class ;
rdfs:label "inferior vena cava ligation sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is an inferior vena cava ligation sham procedure, which follows the same surgical process as an inferior vena cava ligation without blocking the inferior vena cava or any other veins." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000531 a rdfs:Class ;
rdfs:label "gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the transfer (transiently or stably) of the enhanced green fluorescent protein (EGFP) gene, using an adenovirus carrier, into a cell or organism in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0001342 a rdfs:Class ;
rdfs:label "human, adipose-derived stromal cell-conditioned medium" ;
rdfs:comment "This is any condition in which the main influencing factor is human, adipose-derived stromal cell-conditioned medium, which consists of the liquid nutrient medium the cells are grown in plus soluble factors secreted by the cells." ;
rdfs:subClassOf obo:XCO_0001341 .
obo:XCO_0000745 a rdfs:Class ;
rdfs:label "housing with Haemophilus H35-infected subject" ;
rdfs:comment "A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H35 infection during the time period leading up to the specified housing period. Haemophilus H35 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." ;
rdfs:subClassOf obo:XCO_0000742 .
obo:XCO_0000508 a rdfs:Class ;
rdfs:label "audible tone stimulus" ;
rdfs:comment "An auditory stimulus consisting of a sound which is at a frequency and level to be perceptible to the ear, especially the human ear." ;
rdfs:subClassOf obo:XCO_0000048 .
obo:XCO_0001467 a rdfs:Class ;
rdfs:label "controlled 3-chloro-1,2-propanediol content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of 3-chloro-1,2-propanediol, a chlorinated propanediol with antifertility activity in males used as a chemosterilant in rodents." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000230 a rdfs:Class ;
rdfs:label "monoamine hormone" ;
rdfs:comment "A chemical substance consisting of an amine compound which contains one amino group and was derived from an aromatic amino acid, that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body." ;
rdfs:subClassOf obo:XCO_0000125 .
obo:XCO_0000603 a rdfs:Class ;
rdfs:label "hesperetin" ;
rdfs:comment "Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges." ;
rdfs:subClassOf obo:XCO_0000470 .
obo:XCO_0000428 a rdfs:Class ;
rdfs:label "fructose" ;
rdfs:comment "This is any condition in which the main influencing factor is fructose, a monosaccharide isomer of glucose which, although it is a 6-carbon sugar (hexose), generally exists as a 5-member hemiketal ring. Fructose is one of three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion." ;
rdfs:subClassOf obo:XCO_0000274 .
obo:XCO_0001516 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to poly I:C" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to poly I:C that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) poly I:C use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000235 .
obo:XCO_0000520 a rdfs:Class ;
rdfs:label "neuromodulation" ;
rdfs:comment "Any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000519 a rdfs:Class ;
rdfs:label "anti-Shiga toxin 1 beta monoclonal antibody 13C4" ;
rdfs:comment "A condition in which the main influencing factor is an immunoglobulin molecule having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1. This monoclonal antibody has been used as an IgG1 isotype control." ;
rdfs:subClassOf obo:XCO_0000518 .
obo:XCO_0001454 a rdfs:Class ;
rdfs:label "gene transfer of the mNeonGreen gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is the mNeonGreen gene (mNG) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism. This gene codes for a green/yellow fluorescent protein and is used as a control for studying the effects of some other gene." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0000666 a rdfs:Class ;
rdfs:label "bronchodilator agent" ;
rdfs:comment "Any condition in which the main influencing factor is a substance that causes an increase in the expansion of a bronchus or bronchial tubes." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0000585 a rdfs:Class ;
rdfs:label "scrambled control oligodeoxynucleotide" ;
rdfs:comment "A control oligodeoxynucleotide with a non-specific scrambled sequence." ;
rdfs:subClassOf obo:XCO_0000234 .
obo:XCO_0000932 a rdfs:Class ;
rdfs:label "vasopressin" ;
rdfs:comment "This is a family of cyclic nonapeptide hormones found in most mammals. Synthesized in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Vasopressin acts as a vasoconstrictor to increase blood pressure, blood volume, and water reabsorption by the renal collecting ducts." ;
rdfs:subClassOf obo:XCO_0000228 .
obo:XCO_0000322 a rdfs:Class ;
rdfs:label "hexamethonium chloride" ;
rdfs:comment "The compound C12H30Cl2N2, consisting of a hexamethonium cation and dichloride anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself." ;
rdfs:subClassOf obo:XCO_0000320 .
obo:XCO_0001484 a rdfs:Class ;
rdfs:label "in situ ischemic liver condition" ;
rdfs:comment "This is any condition in which the main influencing factor is ischemia of an in situ liver, a liver that remains in the organism at normal body temperature, but not oxygenated by natural circulation, perfusion, or other means." ;
rdfs:subClassOf obo:XCO_0001483 .
obo:XCO_0000813 a rdfs:Class ;
rdfs:label "total body irradiation" ;
rdfs:comment "Total body irradiation (TBI) is a form of radiotherapy (typically X-rays or gamma rays) used primarily as part of the preparative regimen for hematopoietic stem cell (or bone marrow) transplantation." ;
rdfs:subClassOf obo:XCO_0000043 .
obo:XCO_0001126 a rdfs:Class ;
rdfs:label "curcumin" ;
rdfs:comment "This is any condition in which the main influencing factor is curcumin , a beta-diketone that is obtained from tumeric, the powdered root of Curcuma longa. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000435 , obo:XCO_0000505 .
obo:XCO_0000661 a rdfs:Class ;
rdfs:label "one-kidney, one-clip occlusion" ;
rdfs:comment "A surgical manipulation causing blood vessel blockage by the clipping of one renal artery and surgical removal of the contralateral kidney." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0001768 a rdfs:Class ;
rdfs:label "L5 spinal nerve compression sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is an L5 spinal nerve compression sham procedure, which follows the same surgical process as an L5 spinal nerve compression without ligating the cannula to the nerve." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000971 a rdfs:Class ;
rdfs:label "SB525334" ;
rdfs:comment "This is any condition in which the main influencing factor is the chemical SB525334, which decreases or interferes with the activity of the serine/threonine protein kinase Alk5 (activin receptor-like kinase-5)." ;
rdfs:subClassOf obo:XCO_0000970 .
obo:XCO_0001543 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to oxytocin" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to oxytocin that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) oxytocin use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001542 .
obo:XCO_0001009 a rdfs:Class ;
rdfs:label "Media 199" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is M199 medium, which is useful across a wide range of species and applications but is particularly suitable for the culturing of non-transformed cells. M199 medium ingredients may include Earles salts and a bicarbonate/carbonic acid buffering system for the maintenance of pH in a CO2 incubator or Hanks salts with salt solutions designed for atmospheric equilibrium." ;
rdfs:subClassOf obo:XCO_0000966 .
obo:XCO_0001683 a rdfs:Class ;
rdfs:label "maternal exposure to limited bedding and nesting during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to limited bedding and nesting during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) limited bedding and nesting use/exposure during the postnatal, preweaning period on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001679 .
obo:XCO_0000076 a rdfs:Class ;
rdfs:label "coffee" ;
rdfs:comment "A drink made of the decoction or infusion of the dried, roasted sees of Coffea arabica or Coffea canephora." ;
rdfs:subClassOf obo:XCO_0000028 .
obo:XCO_0000740 a rdfs:Class ;
rdfs:label "housing with pathogen-infected subject" ;
rdfs:comment "This is any condition in which the main influencing factor is housing with pathogen-infected subject(s), a situation in which at least one subject in the housing had a pathogenic infection during the time period leading up to the specified housing period." ;
rdfs:subClassOf obo:XCO_0000033 .
obo:XCO_0001347 a rdfs:Class ;
rdfs:label "Compound 1" ;
rdfs:comment "This is any condition in which the main influencing factor is Compound 1, a bicyclic molecule (patented by Merck & Co., Inc.) that can have various substituents and is a soluble guanylate cyclase activator." ;
rdfs:subClassOf obo:XCO_0000695 .
obo:XCO_0000848 a rdfs:Class ;
rdfs:label "negatively charged liposome-entrapped doxorubicin" ;
rdfs:comment "An experimental condition in which the main influencing factor is negatively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication." ;
rdfs:subClassOf obo:XCO_0000539 , obo:XCO_0000782 .
obo:XCO_0000644 a rdfs:Class ;
rdfs:label "anti-T cell receptor antibody" ;
rdfs:comment "A monoclonal antibody that appears to be specific for a constant determinant of the rat alpha/beta heterodimeric T cell receptor." ;
rdfs:subClassOf obo:XCO_0000194 .
obo:XCO_0001831 a rdfs:Class ;
rdfs:label "tetrodotoxin" ;
rdfs:comment "This is any condition in which the main influencing factor is tetrodotoxin, a toxin found mainly in the liver and ovaries of fishes in the order tetraodontiformes. It causes paresthesia and paralysis through interference with neuromuscular conduction." ;
rdfs:subClassOf obo:XCO_0000496 , obo:XCO_0000618 .
obo:XCO_0000778 a rdfs:Class ;
rdfs:label "spiroplatin" ;
rdfs:comment "A condition in which the main influencing factor is spiroplatin, a metal drug and analog of the second generation for cisplatin, developed for the treatment of cancer. Spiroplatin induces DNA cross-linking, thereby inhibiting DNA replication and the synthesis of RNA and protein. Initial clinical trials of spiroplatin showed that it could cause less nausea and vomiting than cisplatin, but development was discontinued due to weak anti-tumor effects and toxicity at high dosages." ;
rdfs:subClassOf obo:XCO_0000399 , obo:XCO_0000435 .
obo:XCO_0000220 a rdfs:Class ;
rdfs:label "anion channel activator" ;
rdfs:comment "Any chemical substance which increases the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000216 .
obo:XCO_0000119 a rdfs:Class ;
rdfs:label "amino acid" ;
rdfs:comment "This is any condition in which the main influencing factor is an amino acid, any naturally occurring or synthetic organic compound containing an amino group, a carboxylic acid group and a side chain. An amino acid may be administered as a nutritional supplement or as a drug." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000035 a rdfs:Class ;
rdfs:label "housing in pairs" ;
rdfs:subClassOf obo:XCO_0000033 .
obo:XCO_0000805 a rdfs:Class ;
rdfs:label "nondamaging retinal laser therapy" ;
rdfs:comment "Nondamaging retinal laser therapy (NRT) is a retinal treatment with a lack of tissue damage. Lack of tissue damage allows high-density treatment patterns to increase therapeutic response and periodic retreatments for chronic macular diseases. It is similar to SRT (selective RPE therapy), but using lower energy to avoid killing retinal pigmented epithelial cells." ;
rdfs:subClassOf obo:XCO_0000803 .
obo:XCO_0001505 a rdfs:Class ;
rdfs:label "tantalum pellet implantation in muscle" ;
rdfs:comment "This is any condition in which the main influencing factor is the surgical implantation of tantalum pellet(s) in muscle. Tantalum implantation serves as a control for other metal implantation because tantalum has great biocompatibility in implants, devices, and stents, and is largely thought to be inert both in vitro and in vivo." ;
rdfs:subClassOf obo:XCO_0001504 .
obo:XCO_0000469 a rdfs:Class ;
rdfs:label "isotretinoin" ;
rdfs:comment "Condition in which the main influencing factor is isotretinoin, a synthetic first generation retinoid compound used for the treatment of severe cases of acne and other skin diseases." ;
rdfs:subClassOf obo:XCO_0000467 .
obo:XCO_0000820 a rdfs:Class ;
rdfs:label "sham gene transfer using an empty plasmid vector pVAX2" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of an empty plasmid vector pVAX2. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines." ;
rdfs:subClassOf obo:XCO_0000819 , obo:XCO_0001744 .
obo:XCO_0001189 a rdfs:Class ;
rdfs:label "metronidazole" ;
rdfs:comment "This is any condition in which the main influencing factor is metronidazole, a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. Metronidazole is frequently used to treat gastrointestinal infections and parasitic infections such as trichomoniasis, giardiasis, and amebiasis. The antiparasitic of properties of metronidazole set it apart from many other antibacterial drugs, allowing it to treat a wider variety of infections." ;
rdfs:subClassOf obo:XCO_0000482 .
obo:XCO_0001364 a rdfs:Class ;
rdfs:label "isoliensinine" ;
rdfs:comment "This is any condition in which the main influencing factor is isoliensinine, a bisbenzylisoquinoline alkaloid isolated from the lotus plant (Nelumbo nucifera Gaertn). Isoliensinine is claimed to have antitumor, cardioprotective, antioxidant, antidepressant, and anti-HIV properties." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000435 , obo:XCO_0000561 .
obo:XCO_0001693 a rdfs:Class ;
rdfs:label "housing with intruder-resident paradigm" ;
rdfs:comment "This is any condition in which the main influencing factor is housing of pairs with intruder-resident paradigm. This paradigm typically involves two male rodents, but may be modified to involve two pregnant-lactating rodents. The experimental purpose of this paradigm is to study social stress." ;
rdfs:subClassOf obo:XCO_0000035 , obo:XCO_0001265 .
obo:XCO_0000199 a rdfs:Class ;
rdfs:label "oxidation-reduction indicator" ;
rdfs:comment "Any substance which indicates the oxidation status of another substance or of a reaction by means of a characteristic change, especially in color." ;
rdfs:subClassOf obo:XCO_0000197 .
obo:XCO_0000763 a rdfs:Class ;
rdfs:label "T cells" ;
rdfs:comment "This is any condition in which the main influencing factor is an injection of T cells (T lymphocytes). T cells are integral to the functioning of the immune system and are at the core of adaptive immunity, the system that tailors the body's immune response to specific pathogens" ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001792 a rdfs:Class ;
rdfs:label "kidney irradiation" ;
rdfs:comment "This is any condition in which the main influencing factor is kidney irradiation, a type of partial body irradiation used to target the kidney(s). In experimental animals, it is used to study the morbitities caused by radiation exposure to the kidneys." ;
rdfs:subClassOf obo:XCO_0000814 .
obo:XCO_0000042 a rdfs:Class ;
rdfs:label "ultraviolet ray exposure" ;
rdfs:comment "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, in the part of the electromagnetic spectrum with wavelengths between about 10 and 400 nm. Ultraviolet radiation can be ionizing or non-ionizing depending on the wavelength." ;
rdfs:subClassOf obo:XCO_0000045 .
obo:XCO_0000002 a rdfs:Class ;
rdfs:label "resting" ;
rdfs:comment "A state in which the organism is not exhibiting any physical exertion." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0001410 a rdfs:Class ;
rdfs:label "GelMA scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a gelatin-methacryloyl (GelMA) scaffold, a tissue scaffold made of methacrylated gelatin (collagen). GelMA has been widely utilized for diverse tissue engineering applications." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0000300 a rdfs:Class ;
rdfs:label "controlled ethanol content drinking water with water as an optional drink source" ;
rdfs:comment "Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied along with additive-free water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), as an additional drink option for consumption by an organism in an experiment." ;
rdfs:subClassOf obo:XCO_0000023 .
obo:XCO_0000580 a rdfs:Class ;
rdfs:label "forced feeding" ;
rdfs:comment "This is any condition in which the main influencing factor is the administration of food or drug by force, especially to a laboratory animal, typically through a tube leading down the throat to the stomach." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0001151 a rdfs:Class ;
rdfs:label "Augmentin" ;
rdfs:comment "This is any condition whose main influencing factor is Augmentin, a fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate. Augmentin is a broad-spectrum antibiotic." .
obo:XCO_0000417 a rdfs:Class ;
rdfs:label "controlled phytoestrogen content diet" ;
rdfs:comment "A solid diet in which the amount of one or more phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000733 a rdfs:Class ;
rdfs:label "sanguinarine" ;
rdfs:comment "This is any condition in which the main influencing factor is sanguinarine, a benzophenanthridine alkaloid derived from Sanguinaria canadensis and poppy Fumaria species, shown to exhibit anti-microbial, anti-tumoral, and anti-inflammatory activities." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000482 , obo:XCO_0000505 .
obo:XCO_0000910 a rdfs:Class ;
rdfs:label "controlled dehydroepiandrosterone content diet" ;
rdfs:comment "A regimen of solid food in which the amount of dehydroepiandrosterone consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000865 .
obo:XCO_0000917 a rdfs:Class ;
rdfs:label "distilled water" ;
rdfs:comment "This is any condition in which the main influencing factor is distilled water, which is purified by successive evaporation and condensation. It is experimentally provided for hydration or as a vehicle control for some dissolved substance." ;
rdfs:subClassOf obo:XCO_0000021 .
obo:XCO_0000953 a rdfs:Class ;
rdfs:label "controlled reserpine content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of reserpine consumed by an organism as part of an experiment. Reserpine is an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2, and has been used as both an antihypertensive drug and an antipsychotic drug." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001369 a rdfs:Class ;
rdfs:label "exosomes" ;
rdfs:comment "This is any condition in which the main influencing factor is exosomes, a subset (~30–150 nm diameter) of extracellular vesicles (EVs) generated by all cells from the endosomal compartment. Exosomes may carry nucleic acids, proteins, lipids, and metabolites." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0000722 a rdfs:Class ;
rdfs:label "solid food deprivation" ;
rdfs:comment "This is any condition in which the main influencing factor is solid food deprivation, a condition in which solid food is withheld for a specified period of time, while nourishment through liquids is provided." ;
rdfs:subClassOf obo:XCO_0000461 .
obo:XCO_0000335 a rdfs:Class ;
rdfs:label "right adrenalectomy" ;
rdfs:comment "The surgical excision of only the adrenal gland on the right side of the body. The right adrenal gland is generally the smaller of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." ;
rdfs:subClassOf obo:XCO_0000305 .
obo:XCO_0000305 a rdfs:Class ;
rdfs:label "unilateral adrenalectomy" ;
rdfs:comment "The surgical excision of only one of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." ;
rdfs:subClassOf obo:XCO_0000303 .
obo:XCO_0000949 a rdfs:Class ;
rdfs:label "PPDA" ;
rdfs:comment "This is any condition in which the main influencing factor is PPDA, a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (NR2C/NR2D) containing receptors." ;
rdfs:subClassOf obo:XCO_0000947 .
obo:XCO_0001871 a rdfs:Class ;
rdfs:label "median nerve transection" ;
rdfs:comment "This is any condition in which the main influencing factor is transection of the median nerve, a model of a peripheral nerve injury. The median nerve is a nerve of the arm that originates from the brachial plexus and is formed from parts of the medial and lateral cords of the brachial plexus, and continues down the arm to enter the forearm with the brachial artery." ;
rdfs:subClassOf obo:XCO_0001373 .
obo:XCO_0001069 a rdfs:Class ;
rdfs:label "sleep restriction" ;
rdfs:comment "This is any condition in which the main influencing factor is sleep restriction, a state caused by inadequate quantity or quality of sleep, including voluntary or involuntary sleeplessness and circadian rhythm sleep. Sleep restriction may be caused by stress, school or job requirements, poor sleeping habits, or an experimentally arranged situation." ;
rdfs:subClassOf obo:XCO_0001068 .
obo:XCO_0001752 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to saline" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to saline. This is a vehicle control condition typically studied to determine the effect of maternal (F0) saline (vehicle) use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001385 .
obo:XCO_0001325 a rdfs:Class ;
rdfs:label "3-aminoisobutyric acid" ;
rdfs:comment "This is any condition in which the main influencing factor is 3-aminoisobutyric acid, which is isobutyric acid in which one of the methyl hydrogens is substituted by an amino group. During exercise, 3-aminoisobutyric acid is secreted by muscle cells into the blood, and when this molecule interacts with adipocytes, it may induce signaling pathways that regulate the metabolism of fats, insulin, and cholesterol." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001290 a rdfs:Class ;
rdfs:label "Achilles tendon transection" ;
rdfs:comment "This is any condition in which the main influencing factor is Achilles tendon transection, a process involving a surgical technique for complete transection of the calcaneal and plantaris tendon to investigate tendon healing in an experimental animal model." ;
rdfs:subClassOf obo:XCO_0001289 .
obo:MESH_D002976 a rdfs:Class .
obo:XCO_0000960 a rdfs:Class ;
rdfs:label "10% CO2, 20% O2, 70% N2" ;
rdfs:comment "This is a condition in which the level of carbon dioxide (10%), oxygen (20%), and nitrogen (70%) in the air surrounding the organism or breathed by the organism is controlled as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000010 , obo:XCO_0000012 , obo:XCO_0001403 .
obo:XCO_0001331 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to oxycodone" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to oxycodone. This is a condition typically studied to determine the effect of maternal (F0) oxycodone use/exposure on the F1 offspring." .
obo:XCO_0000458 a rdfs:Class ;
rdfs:label "controlled retinyl palmitate content diet" ;
rdfs:comment "A solid diet in which the amount of retinyl palmitate is maintained at a specified level. Retinyl palmitate is the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2." ;
rdfs:subClassOf obo:XCO_0000457 .
obo:XCO_0001358 a rdfs:Class ;
rdfs:label "fecal transplantation" ;
rdfs:comment "This is any condition in which the main influencing factor is fecal transplantation, a clinical or experimental procedure to collect feces from a donor and introduce them into a recipient's gastrointestinal tract. In patients the procedure can be used to control an infection of Clostridium difficile (C. diff)." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001526 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to streptozotocin" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to streptozotocin that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) streptozotocin exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000241 .
obo:XCO_0001361 a rdfs:Class ;
rdfs:label "pulmonary artery occlusion sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is a pulmonary artery occlusion sham procedure, which follows the same surgical process as a pulmonary artery occlusion without blocking the pulmonary artery." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000397 a rdfs:Class ;
rdfs:label "bisphenol A" ;
rdfs:comment "A synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor." ;
rdfs:subClassOf obo:XCO_0000396 .
obo:XCO_0000859 a rdfs:Class ;
rdfs:label "rat anti-control-Ab2 T cell line" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies." ;
rdfs:subClassOf obo:XCO_0000858 .
obo:XCO_0001554 a rdfs:Class ;
rdfs:label "Lieber-DeCarli ethanol liquid diet" ;
rdfs:comment "This is any condition in which the main influencing factor is Lieber-DeCarli ethanol liquid diet, a liquid diet whose calories are 35% ethanol, 35% non-alcoholic carbohydrate, 35% fat, and 15% protein. The basic formula makes the ethanol content to be about 8% by volume." ;
rdfs:subClassOf obo:XCO_0001851 .
obo:XCO_0000159 a rdfs:Class ;
rdfs:label "physical restraint in tube type rodent restrainer" ;
rdfs:comment "The use of a tube type rodent restrainer, that is, a hollow cylinder usually made of a rigid clear material in a size that approximates the size of the animal and can be capped at one or both ends to prevent escape, to limit some or all of an animal's normal movements." ;
rdfs:subClassOf obo:XCO_0000158 .
obo:XCO_0000311 a rdfs:Class ;
rdfs:label "potassium ion solution" ;
rdfs:comment "A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000154 .
obo:XCO_0000879 a rdfs:Class ;
rdfs:label "triamcinolone acetonide" ;
rdfs:comment "A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. It is an anti-inflammatory agent used topically in the treatment of various skin disorders." ;
rdfs:subClassOf obo:XCO_0000505 .
obo:XCO_0000790 a rdfs:Class ;
rdfs:label "controlled sodium chloride content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of sodium chloride dissolved in a sufficient quantity of water." ;
rdfs:subClassOf obo:XCO_0000164 .
obo:XCO_0001735 a rdfs:Class ;
rdfs:label "sodium carbonate/sodium bicarbonate buffer" ;
rdfs:comment "This is any condition in which the main influencing factor is sodium carbonate/sodium bicarbonate buffer, a combination of sodium carbonate/sodium bicarbonate in water to form a solution with a pH range of 9.2 to 10.6." ;
rdfs:subClassOf obo:XCO_0000315 .
obo:XCO_0000154 a rdfs:Class ;
rdfs:label "ion/salt solution" ;
rdfs:comment "This is any condition in which the main influencing factor is a homogeneous mixture of one or more ions, i.e. atoms or molecules that have gained or lost electron(s) and thereby acquired a charge, or one or more salts, i.e. members of the large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion), dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000340 .
obo:XCO_0001544 a rdfs:Class ;
rdfs:label "transgenerational maternal exposure to oxytocin" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to oxytocin that has transgenerational effects. This is a condition typically studied to determine the effect of maternal (F0) oxytocin use/exposure on the F2/F3 offspring by direct effects on the F1/F2 generations in utero or during nursing, or by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of F1 offspring to affect the F2 generation. The maternal exposure may be any time after gestational development of germline cells in the F1 generation up to the time of weaning of F1 offspring to affect the F3 generation." ;
rdfs:subClassOf obo:XCO_0001542 .
obo:XCO_0000098 a rdfs:Class ;
rdfs:label "left ovariectomy" ;
rdfs:comment "Surgical removal of the left ovary." ;
rdfs:subClassOf obo:XCO_0000096 .
obo:XCO_0000816 a rdfs:Class ;
rdfs:label "partial-body irradiation with 5% bone marrow sparing" ;
rdfs:comment "Partial-body irradiation with 5% bone marrow sparing (tibiae, ankles, feet) is used to define acute radiation-induced GI-ARS, H-ARS, and acute kidney injury (AKI) as well as the delayed effects of acute radiation exposure (DEARE) characterized by prolonged GI, lung, and heart injury and chronic kidney injury (CKI). This condition/model system allows analysis of concomitant multi-organ sequelae." ;
rdfs:subClassOf obo:XCO_0000814 .
obo:XCO_0000521 a rdfs:Class ;
rdfs:label "direct electrical nerve stimulation" ;
rdfs:comment "This is any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to a specific nerve or nerves, for example through the use of microelectrodes or an implanted device." ;
rdfs:subClassOf obo:XCO_0000520 .
obo:XCO_0001742 a rdfs:Class ;
rdfs:label "gene transfer using plasmid vector pVAX1" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer using plasmid vector pVAX1 as the carrier of the genetic material. The pVAX1 plasmid was designed for use in the development of DNA vaccines." ;
rdfs:subClassOf obo:XCO_0000818 .
obo:XCO_0001230 a rdfs:Class ;
rdfs:label "Imwitor 742" ;
rdfs:comment "This is any condition in which the main influencing factor is Imwitor 742, a blend of mono-, di- and triglycerides, mainly of caprylic and capric acid. Imwitor 742 acts as a solubilizer for poorly soluble drugs in oral administration forms (i.e. capsules), as a penetration enhancer in topical drug forms, and as a co-emulsifier in emulsions." ;
rdfs:subClassOf obo:XCO_0001231 , obo:XCO_0001232 .
obo:XCO_0001070 a rdfs:Class ;
rdfs:label "papain" ;
rdfs:comment "This is any condition in which the main influencing factor is papain, a cysteine protease present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis). In addition to experimental uses in biology research, it has wide ranging commercial applications in the leather, cosmetic, textiles, detergents, food and pharmaceutical industries." ;
rdfs:subClassOf obo:XCO_0000176 .
obo:XCO_0001332 a rdfs:Class ;
rdfs:label "gestational maternal exposure to oxycodone" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to oxycodone. This is a condition typically studied to determine the effect of maternal (F0) oxycodone use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001334 , obo:XCO_0001335 .
obo:XCO_0001122 a rdfs:Class ;
rdfs:label "antianxiety agent" ;
rdfs:comment "This is any condition in which the main influencing factor is an anti-anxiety agent, a medication or other intervention that reduces anxiety. Anxiolytic medications are used for the treatment of anxiety disorders and their related psychological and physical symptoms." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0001515 a rdfs:Class ;
rdfs:label "gestational maternal exposure to methylazoxymethanol acetate" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to methylazoxymethanol acetate. This is a condition typically studied to determine the effect of maternal (F0) methylazoxymethanol acetate use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001514 .
obo:XCO_0001066 a rdfs:Class ;
rdfs:label "LNA-modified anti-rno-miR-21-5p oligonucleotide" ;
rdfs:comment "This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)modified oligonucleotide with an antirat miR-21-5p sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0000856 a rdfs:Class ;
rdfs:label "resveratrol" ;
rdfs:comment "A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups. It is produced by various plants and has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000505 .
obo:XCO_0000018 a rdfs:Class ;
rdfs:label "bilateral nephrectomy" ;
rdfs:comment "Surgical removal of both kidneys." ;
rdfs:subClassOf obo:XCO_0000017 .
obo:XCO_0001836 a rdfs:Class ;
rdfs:label "excisional wound" ;
rdfs:comment "This is any condition in which the main influencing factor is trauma to any of the tissues of the body caused by the act of cutting out part or all of a structure or organ." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0001431 a rdfs:Class ;
rdfs:label "CN-Patch implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a CN-Patch hydrogel, an injectable hydrogel designed for controlled release of CO (carbon monoxide) and NO (nitric oxide) into host soft tissue. Catechol-modified chitosan (Chi-C) and aldehyde dextran (Odex) are used as the basis of the hydrogel for viscosity and hemostatic effects. Gelatin nanoparticles, GSNO (S-Nitrosoglutathione), and CORM-3 (Ru(CO)3Cl(glycinate) ) are suspended/dissolved in the hydrogel to accomplish the release of CO and NO." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0000375 a rdfs:Class ;
rdfs:label "sciatic nerve axotomy" ;
rdfs:comment "Surgical transection or severing of one or more axons of the sciatic nerve, the large sensory and motor nerve that in humans arises from the sacral plexus and passes through the greater sciatic foramen to midthigh where it divides into the common peroneal and tibial nerves." ;
rdfs:subClassOf obo:XCO_0000374 .
obo:XCO_0000390 a rdfs:Class ;
rdfs:label "antimetabolite" ;
rdfs:comment "This is any condition in which the main influencing factor is an antimetabolite, a substance which competes with or replaces a metabolite (a chemical that is part of the normal metabolism of a cell or body), and so prevents or reduces its normal utilization or activity. Antimetabolites are often structurally similar to the metabolite for which they substitute." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001606 a rdfs:Class ;
rdfs:label "maternal exposure to controlled fat content diet during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to a controlled fat content diet during nursing of offspring. This is a condition typically studied to determine the effect of a maternal (F0) controlled fat content diet exposure during the postnatal, preweaning period on the F1 offspring." .
obo:XCO_0001564 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to perfluorohexane sulfonate" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to perfluorohexane sulfonate that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) perfluorohexane sulfonate use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001560 .
obo:XCO_0001555 a rdfs:Class ;
rdfs:label "controlled air ethanol content" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled air ethanol content surrounding an organism or breathed by the organism as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000009 .
obo:XCO_0001383 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to lipopolysaccharide" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to lipopolysaccharide that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) lipopolysaccharide use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000738 .
obo:XCO_0000087 a rdfs:Class ;
rdfs:label "specific pathogen-free condition" ;
rdfs:comment "A standard living condition with the absence of a resident pathogen, a biological agent that causes disease, especially a microorganism such as a bacterium, virus, or fungus." ;
rdfs:subClassOf obo:XCO_0000099 .
obo:XCO_0000935 a rdfs:Class ;
rdfs:label "unilateral renal denervation" ;
rdfs:comment "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and only one kidney, left or right. It is followed by painting of the renal blood vessels with a solution of 10% phenol." ;
rdfs:subClassOf obo:XCO_0000930 .
obo:XCO_0001869 a rdfs:Class ;
rdfs:label "galactic cosmic radiation" ;
rdfs:comment "This is any condition in which the main influencing factor is galactic cosmic radiation (GCR), a type of ionizing radiation present in the Earth's atmosphere that has originated from outside our solar system. GCR consists of high-energy protons and heavy ions." ;
rdfs:subClassOf obo:XCO_0000039 .
obo:XCO_0001527 a rdfs:Class ;
rdfs:label "gestational maternal exposure to streptozotocin" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to streptozotocin. This is a condition typically studied to determine the effect of maternal (F0) streptozotocin exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001526 .
obo:XCO_0000439 a rdfs:Class ;
rdfs:label "controlled 3-methyl-4'-dimethylaminoazobenzene content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of 3-methyl-4'-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, consumed by an organism as part of an experiment." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001854 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to liquid diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to a liquid diet that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) liquid diet exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001552 .
obo:XCO_0001567 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to 6-propyl-2-thiouracil" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to 6-propyl-2-thiouracil that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) 6-propyl-2-thiouracil use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001561 .
obo:XCO_0000058 a rdfs:Class ;
rdfs:label "room temperature" ;
rdfs:comment "The temperature of the air surrounding an organism which is considered the most common level for the facility. For humans the temperature considered most comfortable for a room is between 18 and 27 degrees celsius." ;
rdfs:subClassOf obo:XCO_0000011 .
obo:XCO_0001504 a rdfs:Class ;
rdfs:label "metal pellet implantation in muscle" ;
rdfs:comment "This is any condition in which the main influencing factor is the surgical implantation of some type of metal pellet in muscle. This procedure is used to study the effect of various metals in laboratory models of shrapnel wounds." ;
rdfs:subClassOf obo:XCO_0000027 .
obo:XCO_0001420 a rdfs:Class ;
rdfs:label "transgenerational paternal exposure to distilled deionized water" ;
rdfs:comment "This is any condition in which the main influencing factor is any paternal exposure to distilled, deionized water used as a vehicle control for transgenerational effects of some chemical. This is a condition typically studied to determine the effect of paternal (F0) distilled, deionized water use/exposure on the F2/F3 offspring by direct effects on the F1 generation via germ cell exposure. The paternal exposure may be any time after sexual maturity up to the time of copulation." ;
rdfs:subClassOf obo:XCO_0000101 , obo:XCO_0001416 .
obo:XCO_0001055 a rdfs:Class ;
rdfs:label "luteolin" ;
rdfs:comment "This is any condition in which the main influencing factor is luteolin, a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. Luteolin is a common flavonoid abundantly present in several plant products, including broccoli, pepper, thyme, and celery." ;
rdfs:subClassOf obo:XCO_0000271 , obo:XCO_0000435 , obo:XCO_0000470 , obo:XCO_0000505 .
obo:XCO_0001010 a rdfs:Class ;
rdfs:label "glutamine" ;
rdfs:comment "This is any experimental condition in which the main influencing factor is glutamine, an alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4. Glutamine is used as a supplement in cell culture media." ;
rdfs:subClassOf obo:XCO_0000119 .
obo:XCO_0000845 a rdfs:Class ;
rdfs:label "pregnenolone 16alpha-carbonitrile" ;
rdfs:comment "Any condition in which the main influencing factor is pregnenolone 16alpha-carbonitrile, a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR; Nr1i2)." ;
rdfs:subClassOf obo:XCO_0000091 , obo:XCO_0000135 .
obo:XCO_0000312 a rdfs:Class ;
rdfs:label "potassium chloride solution" ;
rdfs:comment "A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000311 .
obo:XCO_0000789 a rdfs:Class ;
rdfs:label "methylcellulose" ;
rdfs:comment "This is any condition in which the main influencing factor is methylcellulose, a methylester of cellulose used as an emulsifying and suspending agent in cosmetics, pharmaceuticals and the chemical industry. It is used therapeutically as a bulk laxative." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0001107 .
obo:XCO_0000751 a rdfs:Class ;
rdfs:label "unilateral carotid artery occlusion" ;
rdfs:comment "A surgical manipulation causing blockage of one of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries." ;
rdfs:subClassOf obo:XCO_0000704 .
obo:XCO_0001575 a rdfs:Class ;
rdfs:label "gene transfer using an adeno-associated virus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is a gene transfer performed using an adeno-associated virus as the carrier of the genetic material. An adeno-associated virus is a small, non-enveloped, single-stranded DNA virus that is replication-deficient, i.e. it needs a helper virus to replicate. AAV is a promising vector for gene therapy due to its ability to infect both dividing and non-dividing cells, its low immunogenicity, and its ability to mediate long-term expression without integrating into the host genome." ;
rdfs:subClassOf obo:XCO_0000528 .
obo:XCO_0000126 a rdfs:Class ;
rdfs:label "angiotensin" ;
rdfs:comment "A peptide hormone which increases blood pressure by causing blood vessel constriction. Part of the renin-angiotensin system." ;
rdfs:subClassOf obo:XCO_0000141 , obo:XCO_0000228 .
obo:XCO_0001125 a rdfs:Class ;
rdfs:label "amoxicillin" ;
rdfs:comment "This is any condition in which the main influencing factor is amoxicillin, a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. Amoxicillin is a broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration." ;
rdfs:subClassOf obo:XCO_0001202 .
obo:XCO_0000007 a rdfs:Class ;
rdfs:label "walking" ;
rdfs:comment "This is any condition in which the main influencing factor is walking, the act of ambulation, moving oneself forward on legs or on an exercise apparatus." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0000595 a rdfs:Class ;
rdfs:label "surgical manipulation of blood vessels" ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000762 a rdfs:Class ;
rdfs:label "rat anti-Ab2 T cells" ;
rdfs:comment "Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies." ;
rdfs:subClassOf obo:XCO_0000763 .
obo:XCO_0001239 a rdfs:Class ;
rdfs:label "gefitinib" ;
rdfs:comment "This is any condition in which the main influencing factor is gefitinib, an EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000970 .
obo:XCO_0001605 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to controlled fat content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to a controlled fat content diet. This is a condition typically studied to determine the effect of a maternal (F0) controlled fat content diet on the F1 offspring." .
obo:XCO_0000151 a rdfs:Class ;
rdfs:label "chemical time series" ;
rdfs:subClassOf obo:XCO_0000088 .
obo:XCO_0000741 a rdfs:Class ;
rdfs:label "housing with bacterial pathogen-infected subject" ;
rdfs:comment "A condition in which subjects are maintained in housing groups in which at least one subject had a bacterial pathogenic infection during the time period leading up to the specified housing period." ;
rdfs:subClassOf obo:XCO_0000475 , obo:XCO_0000740 .
obo:XCO_0001724 a rdfs:Class ;
rdfs:label "collapsin response mediator protein 2 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is collapsin response mediator protein 2 (CRMP2) presented as multiple antigenic peptides (MAPs), which are four copies of the same peptide epitope synthesized on a lysine-based core (MAPs-4 system)." ;
rdfs:subClassOf obo:XCO_0001703 .
obo:XCO_0000974 a rdfs:Class ;
rdfs:label "bile duct ligation" ;
rdfs:comment "This is a condition in which the main influencing factor is a surgical procedure causing blockage of the bile duct by suture ligation, which leads to acute obstructive jaundice and eventually to liver fibrosis." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000476 a rdfs:Class ;
rdfs:label "Streptococcus pneumoniae" ;
rdfs:comment "A condition in which the primary influencing factor is Streptococcus pneumoniae, a species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers." ;
rdfs:subClassOf obo:XCO_0000475 .
obo:XCO_0001278 a rdfs:Class ;
rdfs:label "controlled nicotinamide content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of nicotinamide, in which the amount of nicotinamide consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0001277 .
obo:XCO_0000498 a rdfs:Class ;
rdfs:label "oxidopamine" ;
rdfs:comment "A condition in which the main influencing factor is oxidopamine, a neurotoxic organic compound used to induce degeneration of dopaminergic neurons in animal models." ;
rdfs:subClassOf obo:XCO_0000495 , obo:XCO_0000497 .
obo:XCO_0001645 a rdfs:Class ;
rdfs:label "pterygopalatine artery occlusion" ;
rdfs:comment "This is any condition in which the main influencing factor is pterygopalatine artery occlusion, an experimental surgical procedure which restricts the amount of cranial blood flowing through the left, right, or both pterygopalatine artery(ies). This procedure is used as part of a more extensive procedure to study intracranial aneurysms in laboratory rats." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0000140 a rdfs:Class ;
rdfs:label "vasodilator" ;
rdfs:comment "A condition in which the main influencing factor is a molecule that functions to dilate or increase the interior diameter of blood vessels." ;
rdfs:subClassOf obo:XCO_0000139 .
obo:XCO_0000840 a rdfs:Class ;
rdfs:label "Eplerenone" ;
rdfs:comment "Any condition in which the main influencing factor is Eplerenone, a steroidal antimineralocorticoid of the spirolactone group and a selective aldosterone receptor antagonist (SARA)." ;
rdfs:subClassOf obo:XCO_0000838 .
obo:XCO_0000238 a rdfs:Class ;
rdfs:label "Kilham rat virus" ;
rdfs:comment "A common parvovirus pathogen which causes largely asymptomatic infections in rats. KRV can be used to model environmental influences in the development of type 1 diabetes mellitus." ;
rdfs:subClassOf obo:XCO_0000237 .
obo:XCO_0000799 a rdfs:Class ;
rdfs:label "ether" ;
rdfs:comment "This is any condition in which the main influencing factor is ether, a mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0001196 .
obo:XCO_0001291 a rdfs:Class ;
rdfs:label "particulate matter" ;
rdfs:comment "This is any condition in which the main influencing factor is particulate matter (particle pollution), a mixture of inhalable, solid particles and liquid droplets found in the air. The size of particulate matter ranges from visible to microscopic." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000100 a rdfs:Class ;
rdfs:label "sham surgical control condition" ;
rdfs:comment "A surgical treatment or procedure that is performed as a control and that is similar to but omits a key therapeutic element of the treatment or procedure under investigation." ;
rdfs:subClassOf obo:XCO_0000099 , obo:XCO_0000165 .
obo:XCO_0000069 a rdfs:Class ;
rdfs:label "standard diet" ;
rdfs:subClassOf obo:XCO_0000019 , obo:XCO_0000099 .
obo:XCO_0000687 a rdfs:Class ;
rdfs:label "cenicriviroc" ;
rdfs:comment "An experimental drug candidate for the treatment of HIV infection and in combination with Tropifexor for non-alcoholic steatohepatitis. It is an inhibitor of CCR2 and CCR5 receptors." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0000657 .
obo:XCO_0001155 a rdfs:Class ;
rdfs:label "disopyramide" ;
rdfs:comment "This is any condition whose main influencing factor is disopyramide, a sodium channel blocker and class I anti-arrhythmic agent with a depressant action on the heart similar to that of guanidine. Disopyramide also possesses some anticholinergic and local anesthetic properties." ;
rdfs:subClassOf obo:XCO_0000618 .
obo:XCO_0001321 a rdfs:Class ;
rdfs:label "3D printed PCL scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a 3D printed polycaprolactone (PCL) scaffold, a tissue scaffold made of the printable, synthetic polymer material polycaprolactone. PCL has been used in bone tissue engineering due to its advantages such as good biocompatibility, slow degradation rate, and the potential for loadbearing applications. PCL has also been tested for tendon repair." ;
rdfs:subClassOf obo:XCO_0001319 .
obo:XCO_0001267 a rdfs:Class ;
rdfs:label "reversed light/dark cycle" ;
rdfs:comment "This is any condition in which the main influencing factor is a reversed light/dark cycle, a light/dark cycle that is opposite of the normal day/night conditions the subject or patient experiences." ;
rdfs:subClassOf obo:XCO_0000459 .
obo:XCO_0000772 a rdfs:Class ;
rdfs:label "controlled cocoa butter content diet" ;
rdfs:comment "A solid diet in which the amount of cocoa butter is maintained at a specified level. Cocoa butter is a pale vegetable fat with a low melting point obtained from cacao beans." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001589 a rdfs:Class ;
rdfs:label "lung ischemia/reperfusion" ;
rdfs:comment "This is any condition in which the main influencing factor is lung ischemia/reperfusion, an experimental surgical procedure which involves clamping/releasing of the pulmonary hilum on one side of the lungs. Blood vessels, nerves, and bronchi pass through the hilum to all the lobes of the lungs." ;
rdfs:subClassOf obo:XCO_0000874 .
obo:XCO_0001077 a rdfs:Class ;
rdfs:label "bisphenol F" ;
rdfs:comment "This is any condition in which the main influencing factor is bisphenol F, an organic compound with the chemical formula (HOC6H4)2CH2. It is structurally related to bisphenol A (BPA), a popular precursor for forming plastics, as both belong to the category of molecules known as bisphenols, which feature two phenol groups connected via a linking group." ;
rdfs:subClassOf obo:XCO_0000396 .
obo:XCO_0001150 a rdfs:Class ;
rdfs:label "compound Z" ;
rdfs:comment "This is any condition whose main influencing factor is compound Z, a pterin phosphate that is an oxidation product of cPMP (fosdenopterin). It is functionally related to a neopterin. Compound Z is a pharmacologically inactive product of fosdenopterin metabolism." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001495 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to sodium carboxymethylcellulose" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to sodium carboxymethylcellulose that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) sodium carboxymethylcellulose use/exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001282 .
obo:XCO_0001416 a rdfs:Class ;
rdfs:label "distilled deionized water" ;
rdfs:comment "This is any condition in which the main influencing factor is distilled, deionized water, a type of purified water that is sequentially distilled and deionized." ;
rdfs:subClassOf obo:XCO_0000917 , obo:XCO_0001119 .
obo:XCO_0001024 a rdfs:Class ;
rdfs:label "BNTA" ;
rdfs:comment "This is any condition in which the main influencing factor is BNTA, a small molecule with ECM modulatory and anti-inflammatory properties that is a potential therapeutic agent for osteoarthritis." ;
rdfs:subClassOf obo:XCO_0000505 .
obo:XCO_0000650 a rdfs:Class ;
rdfs:label "controlled cilazapril content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of cilazapril consumed by an organism as part of an experiment. Cilazapril is a prodrug that is hydrolyzed to its main metabolite cilazaprilat, an inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000046 a rdfs:Class ;
rdfs:label "infrared radiation exposure" ;
rdfs:comment "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths longer than those of visible light, i.e. from approximately 750 to 2500 nm." ;
rdfs:subClassOf obo:XCO_0000044 , obo:XCO_0000045 .
obo:XCO_0001578 a rdfs:Class ;
rdfs:label "choline‐sufficient, amino acid‐defined diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a choline‐sufficient, amino acid‐defined (CSAA) diet. A CSAA diet is often used as a control diet in studies investigating the effects of choline deficiency on liver health, particularly in models of non-alcoholic fatty liver disease (NAFLD)." ;
rdfs:subClassOf obo:XCO_0000014 , obo:XCO_0000099 .
obo:XCO_0000952 a rdfs:Class ;
rdfs:label "controlled perindopril content drinking water" ;
rdfs:comment "This is a condition in which the main influencing factor is a drink made up of water and a specified amount of perindopril consumed by an organism as part of an experiment. Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001308 a rdfs:Class ;
rdfs:label "Erxian decoction" ;
rdfs:comment "This is any condition in which the main influencing factor is Erxian decoction, a six-herb formulation from traditional Chinese medicine (TCM). Erxian decoction (ERX) has been used for the treatment of menopausal symptoms and also for spinal cord injury." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0000767 a rdfs:Class ;
rdfs:label "Schistosoma mansoni" ;
rdfs:comment "A condition in which the main influencing factor is Schistosoma mansoni, a trematode parasite that lives in certain types of freshwater snails. The infectious form of the parasite, known as cercariae, emerge from the snail into the water. Humans can become infected when skin comes in contact with contaminated freshwater." ;
rdfs:subClassOf obo:XCO_0000363 .
obo:XCO_0001405 a rdfs:Class ;
rdfs:label "controlled atmospheric pressure" ;
rdfs:comment "This is any condition in which the main influencing factor is controlled atmospheric pressure, which involves controlling volume of the air, temperature of the air, and humidity of the air breathed. Controlled atmospheric pressure may be achieved by the use of a hypobaric or hyperbaric chamber." ;
rdfs:subClassOf obo:XCO_0000998 .
obo:XCO_0000655 a rdfs:Class ;
rdfs:label "prion" ;
rdfs:comment "An abnormal form of prion protein that in mammals includes pathogenic forms which arise sporadically, as a result of genetic mutation, or by transmission (as by ingestion of infected tissue) and which upon accumulation in the brain cause a prion disease (such as bovine spongiform encephalopathy or Creutzfeldt-Jakob disease." ;
rdfs:subClassOf obo:XCO_0000236 .
obo:XCO_0000622 a rdfs:Class ;
rdfs:label "tritiated quinidine" ;
rdfs:subClassOf obo:XCO_0000171 , obo:XCO_0000617 .
obo:XCO_0000353 a rdfs:Class ;
rdfs:label "central nervous system myelin" ;
rdfs:comment "A condition in which the major influencing factor is the lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers of the central nervous system, i.e., the brain and spinal cord." ;
rdfs:subClassOf obo:XCO_0000352 .
obo:XCO_0001743 a rdfs:Class ;
rdfs:label "sham gene transfer using an empty plasmid vector pVAX1" ;
rdfs:comment "This is any condition in which the main influencing factor is gene transfer of an empty plasmid vector pVAX1 that has been transferred into a cell or organism.. The pVAX1 plasmid was designed for use in the development of DNA vaccines." ;
rdfs:subClassOf obo:XCO_0001742 , obo:XCO_0001744 .
obo:XCO_0000182 a rdfs:Class ;
rdfs:label "controlled exposure to ambient light" ;
rdfs:comment "Condition in which the natural, usual or environmental level and/or time of exposure to visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is controlled." ;
rdfs:subClassOf obo:XCO_0000284 .
obo:XCO_0001044 a rdfs:Class ;
rdfs:label "T9 laminectomy" ;
rdfs:comment "This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of the ninth thoracic vertebra." ;
rdfs:subClassOf obo:XCO_0001043 .
obo:XCO_0001133 a rdfs:Class ;
rdfs:label "bardoxolone" ;
rdfs:comment "This is any condition in which the main influencing factor is bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis." ;
rdfs:subClassOf obo:XCO_0000435 , obo:XCO_0000505 .
obo:XCO_0000628 a rdfs:Class ;
rdfs:label "atorvastatin" ;
rdfs:comment "Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0000680 .
obo:XCO_0000029 a rdfs:Class ;
rdfs:label "controlled carbohydrate content diet" ;
rdfs:comment "A regimen of solid food in which the amount of carbohydrates consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001140 a rdfs:Class ;
rdfs:label "chlormezanone" ;
rdfs:comment "This is any condition in which the main influencing factor is chlormezanone, an anxiolytic drug, a muscle relaxant and an antipsychotic agent whose clinical use was discontinued because of rare but serious cutaneous reactions." ;
rdfs:subClassOf obo:XCO_0001122 .
obo:XCO_0001084 a rdfs:Class ;
rdfs:label "beta-Sitosterol" ;
rdfs:comment "This is any condition in which the main influencing factor is beta-Sitosterol, one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. It is a white, waxy powder with a characteristic odor, and is one of the components of the food additive E499." ;
rdfs:subClassOf obo:XCO_0000091 .
obo:XCO_0001814 a rdfs:Class ;
rdfs:label "experimental nerve injury" ;
rdfs:comment "This is any condition in which the main influencing factor is experimental nerve injury, a penetrating or non-penetrating injury to a nerve resulting from experimentally controlled trauma." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000209 a rdfs:Class ;
rdfs:label "hepatectomy" ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000671 a rdfs:Class ;
rdfs:label "doxycycline" ;
rdfs:comment "A tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000672 .
obo:XCO_0000698 a rdfs:Class ;
rdfs:label "BAY60-4552" ;
rdfs:comment "This chemical belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase." ;
rdfs:subClassOf obo:XCO_0000696 .
obo:XCO_0000824 a rdfs:Class ;
rdfs:label "pertussis toxin" ;
rdfs:comment "Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is one of the most complex bacterial toxins known, composed of six subunits with an A protomer responsible for biologic activities and a B pentamer directing binding and entry of the A subunit into the cytoplasm." ;
rdfs:subClassOf obo:XCO_0000240 .
obo:XCO_0000301 a rdfs:Class ;
rdfs:label "lithium ion solution" ;
rdfs:comment "A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000154 .
obo:XCO_0001413 a rdfs:Class ;
rdfs:label "allisartan" ;
rdfs:comment "This is any condition in which the main influencing factor is allisartan, an orally potent, selective, non-peptide inhibitor of Angiotensin II Type 1 receptors. Allisartan is an antihypertensive agent that protects various organs from damage of high blood pressure." ;
rdfs:subClassOf obo:XCO_0000536 .
obo:XCO_0001754 a rdfs:Class ;
rdfs:label "fentanyl" ;
rdfs:comment "This is any condition in which the main influencing factor is fentanyl, a potent, synthetic opioid analgesic/anesthetic. Fentanyl is primarily a mu-opioid agonist." ;
rdfs:subClassOf obo:XCO_0000135 , obo:XCO_0001329 .
obo:XCO_0001537 a rdfs:Class ;
rdfs:label "transfer of shRNA using a lentivirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is shRNA (short hairpin ribonucleic acid). shRNA is a synthetic RNA molecule that can silence genes in cells. It's a key technology for targeted gene silencing. shRNA is delivered to cells using plasmids, viral vectors, or bacterial vectors" .
obo:XCO_0000115 a rdfs:Class ;
rdfs:label "perfusate" ;
rdfs:comment "Any fluid which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." ;
rdfs:subClassOf obo:XCO_0000340 .
obo:XCO_0001228 a rdfs:Class ;
rdfs:label "electrical muscle stimulation" ;
rdfs:comment "This is any condition in which the main influencing factor is electrical muscle stimulation (EMS), a transcutaneous method of stimulating skeletal muscle. EMS is designed to facilitate passive activation of a large number of motor units and induce synchronous recruitment of muscle fibers, with the aim of strengthening or maintaining muscle mass." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001171 a rdfs:Class ;
rdfs:label "levofloxacin" ;
rdfs:comment "This is any condition whose main influencing factor is levofloxacin, a fluoroquinolone antibiotic that is active against both gram-negative and gram-positive bacteria. Levofloxacin is an inhibitor of both bacterial topoisomerase IV and DNA gyrase." ;
rdfs:subClassOf obo:XCO_0000483 , obo:XCO_0000523 .
obo:XCO_0000943 a rdfs:Class ;
rdfs:label "controlled glucosamine content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine in which the amount of glucosamine consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001549 a rdfs:Class ;
rdfs:label "inorganic chloride" ;
rdfs:comment "This is any condition in which the main influencing factor is inorganic chloride. Chlorine anion (Cl−) is an essential electrolyte located in all body fluids and responsible for maintaining acid/base balance, transmitting nerve impulses, and regulating liquid flow in and out of cells. Chloride compounds contain chlorine atoms bonded to metals like sodium (NaCl), calcium (CaCl2), or magnesium (MgCl2)." ;
rdfs:subClassOf obo:XCO_0000149 .
obo:XCO_0000249 a rdfs:Class ;
rdfs:label "left kidney transplant" ;
rdfs:comment "A surgical procedure in which the left kidney from a donor organism is implanted into a recipient organism." ;
rdfs:subClassOf obo:XCO_0000248 .
obo:XCO_0001252 a rdfs:Class ;
rdfs:label "PC-AR" ;
rdfs:comment "This is any condition in which the main influencing factor is PC-AR, an extract derived from a 60%-40% mix (by weight) of Poria cocos and Alismatis rhizoma." .
obo:XCO_0000393 a rdfs:Class ;
rdfs:label "1,2-dimethylhydrazine" ;
rdfs:comment "A condition in which the main influencing factor is 1,2-dimethylhydrazine, DNA alkylating agent that is a potent carcinogen; used to induce colon tumours in experimental animals." ;
rdfs:subClassOf obo:XCO_0000089 , obo:XCO_0000205 .
obo:XCO_0001375 a rdfs:Class ;
rdfs:label "spared nerve injury sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is spared nerve injury sham surgery, which follows the same surgical process as a spared nerve injury without the ligation/transection of the common peroneal and tibial nerves." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000957 a rdfs:Class ;
rdfs:label "artificial cerebrospinal fluid with 0.15 M sodium" ;
rdfs:comment "This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.15 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid." ;
rdfs:subClassOf obo:XCO_0000830 .
obo:XCO_0001803 a rdfs:Class ;
rdfs:label "transfer of negative control GalNAc-conjugated siRNA" ;
rdfs:comment "This is any condition in which the main influencing factor is negative control siRNA conjugated to N-acetylgalactosamine, which allows directed delivery of siRNA to the liver by targeting the asialoglycoprotein receptor. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences." ;
rdfs:subClassOf obo:XCO_0001510 .
obo:XCO_0001510 a rdfs:Class ;
rdfs:label "transfer of negative control siRNA" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of negative control siRNA (small interfering RNA) delivered by transfection or transduction (transfer by virus). Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences. Transfection may be accomplished with chemical, physical, or nonviral biological methods." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0000809 a rdfs:Class ;
rdfs:label "2-methyl-6-(phenylethynyl)pyridine" ;
rdfs:comment "This is any condition in which the main influencing factor is 2-methyl-6-(phenylethynyl)pyridine, a methylpyridine that consists of 2-methylpyridine bearing an additional phenylethynyl group at position 6. It is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. It functions as an excitatory amino acid antagonist and an anxiolytic agent." ;
rdfs:subClassOf obo:XCO_0000160 , obo:XCO_0001122 .
obo:XCO_0001522 a rdfs:Class ;
rdfs:label "gestational maternal exposure to controlled air oxygen content" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to controlled air oxygen content. This is a condition typically studied to determine the effect of maternal (F0) controlled air oxygen content exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001520 .
obo:XCO_0000274 a rdfs:Class ;
rdfs:label "monosaccharide" ;
rdfs:comment "Any simple carbohydrate consisting of a single basic sugar unit with the general formula Cn(H2O)n, with n ranging from 3 to 8." ;
rdfs:subClassOf obo:XCO_0000172 .
obo:XCO_0000350 a rdfs:Class ;
rdfs:label "streptococcal cell wall" ;
rdfs:comment "A biologic agent consisting of a more or less purified preparation of cell walls from streptococcus bacteria. Streptococcus is a genus of spherical Gram-positive bacteria belonging to the phylum Firmicutes and the lactic acid bacteria group. The cell wall is the rigid structure that lies just outside of and is joined to the plasma membrane of plant cells and most prokaryotic cells, which protects the cell and maintains its shape." ;
rdfs:subClassOf obo:XCO_0000349 .
obo:XCO_0001825 a rdfs:Class ;
rdfs:label "Staphylococcus aureus" ;
rdfs:comment "This is any condition in which the main influencing factor is Staphylococcus aureus, a Gram-positive spherical bacteria that is a facultative anaerobe. S. aureus is frequently found on the skin and in the upper respiratory tract in healthy individuals but can become an opportunistic pathogen." ;
rdfs:subClassOf obo:XCO_0000475 .
obo:XCO_0001617 a rdfs:Class ;
rdfs:label "partial body near-infrared II laser irradiation" ;
rdfs:comment "This is any condition in which the main influencing factor is partial body near-infrared II laser irradiation, which is exposure to laser-emitted, electromagnetic radiation with wavelengths ranging from 1000 to 1700 nm. Near-infrared II electromagnetic radiation may be used analytically or as part of a therapeutic process." ;
rdfs:subClassOf obo:XCO_0001616 .
obo:XCO_0001538 a rdfs:Class ;
rdfs:label "transfer of rat Vdr shRNA using a lentivirus vector" ;
rdfs:comment "This is a condition in which rat Vdr shRNA (vitamin D (1,25-dihydroxyvitamin D3) receptor-specific short hairpin RNA) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of Vdr in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0001537 .
obo:XCO_0001241 a rdfs:Class ;
rdfs:label "tienilic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is tienilic acid, a loop diuretic with uricosuric action. Tienilic acid was marketed for the treatment of hypertension until being withdrawn in 1982 because of reports of hepatotoxicity." ;
rdfs:subClassOf obo:XCO_0000122 , obo:XCO_0000863 .
obo:XCO_0000263 a rdfs:Class ;
rdfs:label "pristane" ;
rdfs:comment "This is any condition in which the main influencing factor is pristane, an acyclic saturated hydrocarbon derived from phytane by loss of its C-16 terminal methyl group. Pristane has a role as a biomarker and an immunological adjuvant. It is a norterpene and a long-chain alkane." ;
rdfs:subClassOf obo:XCO_0000133 , obo:XCO_0000261 .
obo:XCO_0001560 a rdfs:Class ;
rdfs:label "perfluorohexane sulfonate" ;
rdfs:comment "This is any condition in which the main influencing factor is perfluorohexane sulfonate, the conjugate base of perfluorohexanesulfonic acid." ;
rdfs:subClassOf obo:XCO_0001559 .
obo:XCO_0000542 a rdfs:Class ;
rdfs:label "enalapril" ;
rdfs:comment "This is any condition in which the main influencing factor is enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0000924 a rdfs:Class ;
rdfs:label "isolated lung perfusion with floxuridine" ;
rdfs:comment "This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with a solution containing floxuridine, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle." ;
rdfs:subClassOf obo:XCO_0000875 , obo:XCO_0000876 .
obo:XCO_0000382 a rdfs:Class ;
rdfs:label "controlled captopril content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of captopril consumed by an organism as part of an experiment. Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000963 a rdfs:Class ;
rdfs:label "controlled NG-nitroarginine methyl ester content in acidified drinking water" ;
rdfs:comment "This is a drink made up of acidified water (pH 2.4-2.8) and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment." ;
rdfs:subClassOf obo:XCO_0000285 .
obo:XCO_0000070 a rdfs:Class ;
rdfs:label "alcoholic drink" ;
rdfs:comment "A drink containing ethanol, a transparent, colorless, volatile, flammable liquid, which is formed by microbial fermentation of carbohydrates." ;
rdfs:subClassOf obo:XCO_0000020 .
obo:XCO_0001059 a rdfs:Class ;
rdfs:label "controlled content saline drink" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of saline (0.9% sodium chloride solution) and a specified amount of one or more solutes." ;
rdfs:subClassOf obo:XCO_0000020 , obo:XCO_0000156 .
obo:XCO_0001019 a rdfs:Class ;
rdfs:label "olanzapine" ;
rdfs:comment "This is any condition in which the main influencing factor is olanzapine, a benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0000591 a rdfs:Class ;
rdfs:label "quinapril" ;
rdfs:comment "A prodrug that is metabolized to quinaprilat (quinapril diacid), a competitive inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0001427 a rdfs:Class ;
rdfs:label "Schwann cells" ;
rdfs:comment "This is a condition in which the main influencing factor is Schwann cells, glial cells that myelinate or ensheath axons in the peripheral nervous system. Some Schwann cells, repair (Bungner) Schwann cells, are only activated upon nerve injury." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001424 a rdfs:Class ;
rdfs:label "corneal de-epithelialization" ;
rdfs:comment "This is any condition in which the main influencing factor is corneal de-epithelialization, an experimental removal of the corneal epithelium of the eye for the purpose of studying the healing process related to clinical procedures like photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). The experimental corneal de-epithelialization may be achieved by mechanical means, or a combination of chemical and mechanical means." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000092 a rdfs:Class ;
rdfs:label "17 beta-estradiol" ;
rdfs:comment "The predominant circulating form of estrogen, the female sex hormone." ;
rdfs:subClassOf obo:XCO_0000294 .
obo:XCO_0001394 a rdfs:Class ;
rdfs:label "osteotomy" ;
rdfs:comment "This is any condition in which the main influencing factor is osteotomy, a surgical cutting of bone. Osteotomy may be used clinically to correct an orthopedic defect or experimentally to study fracture healing." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000676 a rdfs:Class ;
rdfs:label "gene transfer of the rat erb-b2 receptor tyrosine kinase 2 gene using a retrovirus vector" ;
rdfs:comment "A condition in which the rat erb-b2 receptor tyrosine kinase 2 gene (Erbb2) gene has been (transiently or stably) transferred into a cell or organism using a retrovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000675 .
obo:XCO_0000939 a rdfs:Class ;
rdfs:label "JTT-608" ;
rdfs:comment "This is a hypoglycemic drug which enhances glucose-stimulated insulin secretion." ;
rdfs:subClassOf obo:XCO_0000251 , obo:XCO_0000407 .
obo:XCO_0001649 a rdfs:Class ;
rdfs:label "leucine" ;
rdfs:comment "This is any condition in which the main influencing factor is leucine, an essential branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group. Leucine is important for hemoglobin formation and may be used by skeletal muscle during exercise to generate energy." ;
rdfs:subClassOf obo:XCO_0000119 .
obo:XCO_0000756 a rdfs:Class ;
rdfs:label "Kolliphor HS 15" ;
rdfs:comment "This is any condition in which the main influencing factor is Kolliphor HS 15, a non-ionic surfactant and emulsifier that is a potential therapeutic agent because of its effectiveness for reversing multidrug resistance in vitro and its low toxicity in vivo." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0001232 , obo:XCO_0001248 .
obo:XCO_0000639 a rdfs:Class ;
rdfs:label "V1-Cal" ;
rdfs:comment "Peptides developed according to the calcineurin A-interacting site on the C-terminus of Trpv1 was were synthesized as 1 polypeptide with transactivator of transcription (TAT)47‐57 carrier in the following order: N‐terminusTAT47‐57spacer (Gly‐Gly)cargoC terminus." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0000361 a rdfs:Class ;
rdfs:label "left L3-L5 ventral root avulsion" ;
rdfs:comment "The forcible surgical separation from the spine of the motor root of a left side spinal nerve between the #3 and #5 lumbar vertebrae." ;
rdfs:subClassOf obo:XCO_0000401 .
obo:XCO_0001455 a rdfs:Class ;
rdfs:label "heroin" ;
rdfs:comment "This is any condition in which the main influencing factor is heroin, a morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. Heroin has a role as an opioid analgesic, a mu-opioid receptor agonist and a prodrug." .
obo:XCO_0001713 a rdfs:Class ;
rdfs:label "lactate dehydrogenase A" ;
rdfs:comment "This is any condition in which the main influencing factor is lactate dehydrogenase A (LDHA), a subunit of an enzyme with L-lactate dehydrogenase (NAD+) activity that is involved in a post-glycolytic process." ;
rdfs:subClassOf obo:XCO_0000260 .
obo:XCO_0000184 a rdfs:Class ;
rdfs:label "calcium ion" ;
rdfs:comment "The divalent cation of calcium, the chemical element with symbol Ca and atomic number 20." ;
rdfs:subClassOf obo:XCO_0000149 .
a rdfs:Class ;
rdfs:comment "An unconstrained type or object" .
obo:XCO_0001435 a rdfs:Class ;
rdfs:label "worker behavior in a Skinner box within a worker/parasite group feeding/reward paradigm" ;
rdfs:comment "This is any condition in which the main influencing factor is acting as a servant (worker) in a group feeding/reward paradigm in a customized Skinner box, an experimental setup to designed to create parasite-worker social relationships between subjects. The worker subject performs most of the required lever presses to earn a reward (food), while the parasite subjects eat most of the rewarded food." ;
rdfs:subClassOf obo:XCO_0000491 .
obo:XCO_0000510 a rdfs:Class ;
rdfs:label "coronal plane rotational velocity of the head" ;
rdfs:comment "An experimental condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at a relatively constant velocity." ;
rdfs:subClassOf obo:XCO_0000503 .
obo:XCO_0000979 a rdfs:Class ;
rdfs:label "controlled acetyl-L-carnitine content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of acetyl-L-carnitine in which the amount of acetyl-L-carnitine consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 , obo:XCO_0000978 .
obo:XCO_0001245 a rdfs:Class ;
rdfs:label "antiemetic" ;
rdfs:comment "This is any condition in which the main influencing factor is an antiemetic, a drug used to prevent nausea or vomiting. An antiemetic may affect the medullary control centers (the vomiting center and the chemoreceptive trigger zone) or peripheral receptors." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0000406 a rdfs:Class ;
rdfs:label "controlled bisphenol A content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of bisphenol A consumed by an organism as part of an experiment. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000227 a rdfs:Class ;
rdfs:label "charybdotoxin" ;
rdfs:comment "A 37 amino acid peptide neurotoxin from scorpion venom that is a blocker of large- and intermediate-conductance Ca2+-activated K+ channels." ;
rdfs:subClassOf obo:XCO_0000225 .
obo:XCO_0001274 a rdfs:Class ;
rdfs:label "telmisartan" ;
rdfs:comment "This is any condition in which the main influencing factor is telmisartan, a biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist used in the management of hypertension." ;
rdfs:subClassOf obo:XCO_0000523 , obo:XCO_0000536 .
obo:XCO_0000446 a rdfs:Class ;
rdfs:label "estrus cycle" ;
rdfs:comment "One of the two types of reproductive cycles. Specifically, the correlated phenomena of the endocrine and reproductive systems of a female (especially, non-primate) mammal resulting in regularly occurring periods during which the female is sexually active and receptive, estrus, separated by periods in which there is no sexual receptivity." ;
rdfs:subClassOf obo:XCO_0000411 .
obo:XCO_0000165 a rdfs:Class ;
rdfs:label "surgical manipulation" ;
rdfs:comment "This is any process involving manual and instrumental techniques for incision or excision of a part of an organism to investigate and/or treat a pathological condition." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000323 a rdfs:Class ;
rdfs:label "alcohol" ;
rdfs:comment "Any condition in which the main influencing factor is an alcohol, a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0000195 a rdfs:Class ;
rdfs:label "myelin oligodendrocyte glycoprotein" ;
rdfs:comment "A membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is considered a primary target antigen involved in immune-mediated demyelination." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0001559 a rdfs:Class ;
rdfs:label "per- and polyfluoroalkyl substances" ;
rdfs:comment "This is any condition in which the main influencing factor is a per- or polyfluoroalkyl substance. These are organofluorine compounds that have multiple fluorine atoms attached to an alkyl chain (perfluoroalkyl compounds have carbon chain atoms that are completely fluorinated and polyfluoroalkyl compounds have at least one of the carbon atoms in the alkyl chain not fully fluorinated)." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001866 a rdfs:Class ;
rdfs:label "cholic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is cholic acid, a bile salt that facilitates fat absorption and cholesterol excretion." ;
rdfs:subClassOf obo:XCO_0000091 .
obo:XCO_0000316 a rdfs:Class ;
rdfs:label "calcium-free buffer solution" ;
rdfs:comment "A homogeneous mixture which does not contain calcium, the chemical element with atomic number 20, but does contain molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." ;
rdfs:subClassOf obo:XCO_0000315 .
obo:XCO_0001182 a rdfs:Class ;
rdfs:label "methyldopa" ;
rdfs:comment "This is any condition in which the main influencing factor is methyldopa, a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa is in the alpha-2 adrenergic receptor agonist family of medications. It works by stimulating the brain to decrease the activity of the sympathetic nervous system." ;
rdfs:subClassOf obo:XCO_0000673 , obo:XCO_0000863 .
obo:XCO_0000968 a rdfs:Class ;
rdfs:label "experimental traumatic brain injury" ;
rdfs:comment "This is a condition induced by an experimental surgical procedure involving fluid percussion, cortical impact, penetration, or weight drop/impact acceleration to produce controlled injury to the brain." ;
rdfs:subClassOf obo:XCO_0000165 .
obo:XCO_0000902 a rdfs:Class ;
rdfs:label "controlled candesartan content drinking water" ;
rdfs:comment "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of candesartan in which the amount of candesartan consumed is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000626 a rdfs:Class ;
rdfs:label "removal of maxillary molar crown" ;
rdfs:comment "Surgical removal of a maxillary molar crown at the gingival line." ;
rdfs:subClassOf obo:XCO_0000026 .
obo:XCO_0000435 a rdfs:Class ;
rdfs:label "antineoplastic agent" ;
rdfs:comment "This is any condition in which the main influencing factor is any chemical that inhibits or prevents the proliferation of neoplasms." ;
rdfs:subClassOf obo:XCO_0000341 , obo:XCO_0000850 .
obo:XCO_0000532 a rdfs:Class ;
rdfs:label "protein synthesis inhibitor" ;
rdfs:comment "Any condition in which the main influencing factor is a substance which disrupts one or more of the processes that lead directly to the generation of new proteins, that is, that inhibits the process of translation of mRNAs into proteins." ;
rdfs:subClassOf obo:XCO_0000120 .
obo:XCO_0000054 a rdfs:Class ;
rdfs:label "targeted cold exposure" ;
rdfs:comment "An activity or condition involving a low temperature directed toward a particular part of an organism's body." ;
rdfs:subClassOf obo:XCO_0000306 .
obo:XCO_0000794 a rdfs:Class ;
rdfs:label "gene transfer of the lin-28 homolog B gene using an adenovirus vector" ;
rdfs:comment "A condition in which the lin-28 homolog B gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000529 .
obo:XCO_0001548 a rdfs:Class ;
rdfs:label "manganese(II) chloride tetrahydrate" ;
rdfs:comment "This is any condition in which the main influencing factor is manganese(II) chloride tetrahydrate, the tetrahydrate form of manganese(II) chloride. Manganese(II) chloride tetrahydrate has a role as a nutraceutical and a MRI contrast agent. Upon administration, manganese may act as an adjuvant and induce both humoral and cellular immune responses." ;
rdfs:subClassOf obo:XCO_0001549 .
obo:XCO_0000364 a rdfs:Class ;
rdfs:label "Toxoplasma gondii" ;
rdfs:comment "A condition in which the main influencing factor is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis." ;
rdfs:subClassOf obo:XCO_0000363 .
obo:XCO_0001193 a rdfs:Class ;
rdfs:label "naproxen" ;
rdfs:comment "This is any condition in which the main influencing factor is naproxen, a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness. Naproxen inhibits both the COX-1 and COX-2 enzymes." ;
rdfs:subClassOf obo:XCO_0000506 .
obo:XCO_0000122 a rdfs:Class ;
rdfs:label "diuretic" ;
rdfs:comment "A chemical which tends to increase the excretion of urine." ;
rdfs:subClassOf obo:XCO_0000341 .
obo:XCO_0001690 a rdfs:Class ;
rdfs:label "MitoQ-NP" ;
rdfs:comment "This is any condition in which the main influencing factor is nanoparticle-bound mitoquinone, a particle with a size between 1 and 100 nanometers that has mitoquinone attached to it. This particle allows delivery of mitoquinone to the placenta without crossing the placenta." .
obo:XCO_0001616 a rdfs:Class ;
rdfs:label "partial body near-infrared laser irradiation" ;
rdfs:comment "This is any condition in which the main influencing factor is partial body near-infrared laser irradiation, which is exposure to laser-emitted, electromagnetic radiation with wavelengths ranging from 750 to 2500 nm. Near-infrared electromagnetic radiation may be used analytically or as part of a therapeutic process." ;
rdfs:subClassOf obo:XCO_0000046 , obo:XCO_0000804 .
obo:XCO_0000615 a rdfs:Class ;
rdfs:label "embolism injection of middle cerebral artery" ;
rdfs:comment "This is a condition in which the main influencing factor is an injection of a coagulated blood clot to the middle cerebral artery to induce an embolic stroke in an experimental subject." ;
rdfs:subClassOf obo:XCO_0000347 .
obo:XCO_0000285 a rdfs:Class ;
rdfs:label "controlled NG-nitroarginine methyl ester content drinking water" ;
rdfs:comment "A drink made up of water and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0000081 a rdfs:Class ;
rdfs:label "body position" ;
rdfs:comment "The attitude or posture of the body." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001021 a rdfs:Class ;
rdfs:label "controlled docosahexaenoic acid content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a solid diet in which the amount of docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds, is maintained at a specified level." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001838 a rdfs:Class ;
rdfs:label "prucalopride succinate" ;
rdfs:comment "This is any condition in which the main influencing factor is prucalopride succinate, a serotonin receptor agonist used as a treatment for constipation." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0001656 a rdfs:Class ;
rdfs:label "gestational maternal exposure to sucrose" ;
rdfs:comment "This is any condition in which the main influencing factor is any gestational maternal exposure to sucrose. This is a condition typically studied to determine the effect of maternal (F0) sucrose exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0000420 , obo:XCO_0001655 .
obo:XCO_0000537 a rdfs:Class ;
rdfs:label "olmesartan medoxomil" ;
rdfs:comment "This is any condition in which the main influencing factor is olmesartan medoxomil, an angiotensin II receptor blocker which is used as an antihypertensive agent." ;
rdfs:subClassOf obo:XCO_0000536 .
obo:XCO_0001002 a rdfs:Class ;
rdfs:label "variable ventilation" ;
rdfs:comment "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator using variable tidal volume, or variable pressure support, and/or variable respiratory rate." ;
rdfs:subClassOf obo:XCO_0000999 .
obo:XCO_0000024 a rdfs:Class ;
rdfs:label "controlled iron content diet" ;
rdfs:comment "A regimen of solid food in which the amount of iron consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000920 .
obo:XCO_0000785 a rdfs:Class ;
rdfs:label "PROb cells" ;
rdfs:comment "A condition in which the main influencing factor is a rat cell line derived from a colonic adenocarcinoma induced by 1,2- dimethylhydrazine in BDIX rats." ;
rdfs:subClassOf obo:XCO_0000709 .
obo:XCO_0001013 a rdfs:Class ;
rdfs:label "transfer of rat RBPMS siRNA using a lentivirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is transfer of rat RBPMS (RNA binding protein, mRNA processing factor)-specific siRNA in a lentivirus vector. This siRNA has been transferred into a cell or organism using a lentivirus carrier in order to block synthesis of RBPMS in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000233 .
obo:XCO_0001721 a rdfs:Class ;
rdfs:label "stress induced phosphoprotein 1 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is stress induced phosphoprotein 1 (STIP1) presented as multiple antigenic peptides (MAPs), which are four copies of the same peptide epitope synthesized on a lysine-based core (MAPs-4 system)." ;
rdfs:subClassOf obo:XCO_0001704 .
obo:XCO_0000693 a rdfs:Class ;
rdfs:label "cholinergic agonist" ;
rdfs:comment "An agent that selectively binds to and activates cholinergic receptors." ;
rdfs:subClassOf obo:XCO_0000135 .
obo:XCO_0001116 a rdfs:Class ;
rdfs:label "controlled (6S)-5-methyltetrahydrofolic acid content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled (6S)-5-methyltetrahydrofolic acid content diet, a solid diet in which the amount of (6S)-5-methyltetrahydrofolic acid is maintained at a specified level. (6S)-5-methyltetrahydrofolic acid is the primary biologically active form of folate (vitamin B9)." ;
rdfs:subClassOf obo:XCO_0000690 .
obo:XCO_0001487 a rdfs:Class ;
rdfs:label "kainic acid" ;
rdfs:comment "This is any condition in which the main influencing factor is kainic acid, a dicarboxylic acid, a pyrrolidinecarboxylic acid, a L-proline derivative and a non-proteinogenic L-alpha-amino acid. It has a role as an antinematodal drug and an excitatory amino acid agonist. Like many excitatory amino acid agonists it can cause neurotoxicity. Kainic acid is used to cause neurotoxicity and seizures in laboratory animals." ;
rdfs:subClassOf obo:XCO_0000119 , obo:XCO_0000886 .
obo:XCO_0000801 a rdfs:Class ;
rdfs:label "controlled gliadin content diet" ;
rdfs:comment "A regimen of solid food in which the amount of gliadin consumed is controlled. Gliadins are a group of proteins called alpha, beta, gamma and omega according to their relative electrophoretic mobility in gels. They are the major component of wheat gluten and made up of single-chain polypeptides with an average molecular weight of 25100 kDa linked by intramolecular disulfide bonds." ;
rdfs:subClassOf obo:XCO_0000030 .
obo:XCO_0001865 a rdfs:Class ;
rdfs:label "Bruceine A" ;
rdfs:comment "This is any condition in which the main influencing factor is Bruceine A, a compound derived from the fruit of the Brucea javanica plant which inhibits DNA and protein synthesis." ;
rdfs:subClassOf obo:XCO_0000120 , obo:XCO_0000482 .
obo:XCO_0000548 a rdfs:Class ;
rdfs:label "ramipril" ;
rdfs:comment "An experimental condition in which the main influencing factor is ramipril, a prodrug that is metabolized in the liver to ramiprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE)." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0000013 a rdfs:Class ;
rdfs:label "diet" ;
rdfs:comment "The food and drink consumed by an organism day to day." ;
rdfs:subClassOf obo:XCO_0001365 .
obo:MESH_D011345 a rdfs:Class .
obo:XCO_0000570 a rdfs:Class ;
rdfs:label "tolvaptan" ;
rdfs:comment "A selective and competitive arginine vasopressin receptor 2 antagonist." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:XCO_0001757 a rdfs:Class ;
rdfs:label "gestational maternal exposure to fentanyl" ;
rdfs:comment "This is any condition in which the main influencing factor is gestational maternal exposure to fentanyl. This is a condition typically studied to determine the effect of maternal (F0) fentanyl use/exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001755 .
obo:XCO_0000514 a rdfs:Class ;
rdfs:label "metoprolol" ;
rdfs:comment "A condition in which the main influencing factor is metoprolol, a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches." ;
rdfs:subClassOf obo:XCO_0000336 , obo:XCO_0000396 .
obo:XCO_0001753 a rdfs:Class ;
rdfs:label "maternal exposure to saline during nursing" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to saline during nursing of offspring. This is a condition typically studied to determine the effect of maternal (F0) saline (vehicle) use/exposure during the postnatal, preweaning period on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001385 .
obo:XCO_0001678 a rdfs:Class ;
rdfs:label "controlled whole egg content diet" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled whole egg content diet, a regimen of solid food in which the amount of whole dried chicken egg consumed is controlled. A whole egg lab chow diet is one which has close to half of the total chow weight made up of powdered chicken eggs." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0001731 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to gene transfer of enhanced green fluorescent protein gene using an adenovirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector that has multigenerational effects. This is a condition typically studied to determine the effect of maternal (F0) exposure to gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0000531 .
obo:XCO_0001144 a rdfs:Class ;
rdfs:label "chlorpropamide" ;
rdfs:comment "Thhis is any condition in which the main influencing factor is chlorpropamide, an N-sulfonylurea that is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification." ;
rdfs:subClassOf obo:XCO_0000407 .
obo:XCO_0001105 a rdfs:Class ;
rdfs:label "controlled in situ ophthalmic condition" ;
rdfs:comment "This is any condition in which the main influencing factor is a controlled in situ ophthalmic condition, an experimental or medical condition in which the internal or external environment of the eye(s) is altered." ;
rdfs:subClassOf obo:XCO_0000166 .
obo:XCO_0000834 a rdfs:Class ;
rdfs:label "formaldehyde" ;
rdfs:comment "Any condition in which the main influencing factor is formaldehyde, an aldehyde resulting from the formal oxidation of methanol. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative." ;
rdfs:subClassOf obo:XCO_0000239 .
obo:XCO_0001160 a rdfs:Class ;
rdfs:label "flucloxacillin" ;
rdfs:comment "This is any condition in which the main influencing factor is flucloxacillin, a penicillin anti-bacterial drug used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone" ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0000132 a rdfs:Class ;
rdfs:label "acepromazine" ;
rdfs:comment "A phenothiazine-derivative antipsychotic drug used in animals as a sedative and antiemetic and which can also cause peripheral vasodilation." ;
rdfs:subClassOf obo:XCO_0000106 , obo:XCO_0000140 , obo:XCO_0001245 .
obo:XCO_0000998 a rdfs:Class ;
rdfs:label "controlled breathing condition" ;
rdfs:comment "This is any condition in which the main influencing factor is control of the process of breathing, whether by the control of the volume of air breathed or by control of the contents of the breathed air. This may be for the treatment of disease or for the experimental study of physiology or pathology." ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0000588 a rdfs:Class ;
rdfs:label "perindopril" ;
rdfs:comment "Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:XCO_0001638 a rdfs:Class ;
rdfs:label "dipentyl phthalate" ;
rdfs:comment "This is any condition in which the main influencing factor is dipentyl phthalate, a phthalate ester that is the dipentyl ester of benzene-1,2-dicarboxylic acid. Dipentyl phthalate is a phthalate ester, a diester, and a male reproductive toxicant." ;
rdfs:subClassOf obo:XCO_0000239 , obo:XCO_0000511 .
obo:XCO_0000773 a rdfs:Class ;
rdfs:label "controlled soybean oil content diet" ;
rdfs:comment "A solid diet in which the amount of soybean oil is maintained at a specified level. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols." ;
rdfs:subClassOf obo:XCO_0000454 .
obo:XCO_0000700 a rdfs:Class ;
rdfs:label "controlled BAY60-4552 content diet" ;
rdfs:comment "A regimen of solid food in which the amount of BAY60-4552 consumed is controlled." ;
rdfs:subClassOf obo:XCO_0000014 .
obo:XCO_0000525 a rdfs:Class ;
rdfs:label "benazepril" ;
rdfs:comment "A condition in which the main influencing factor is benazepril, a benzazepine in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety of benazeprilat has been converted to the corresponding ethyl ester. Removal of the ester by the liver converts the prodrug back to its active form, benazeprilat. Benazepril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy." ;
rdfs:subClassOf obo:XCO_0000524 .
obo:CHEBI_46631 a rdfs:Class .
obo:XCO_0001304 a rdfs:Class ;
rdfs:label "Danlu tongdu" ;
rdfs:comment "This is any condition in which the main influencing factor is Danlu tongdu, a Chinese patent medicine made up of five traditional Chinese drugs, including Salviae miltiorrhizae, Astragali radix, Eucommiae cortex, Corydalis rhizoma and Cervi cornus colla. Danlu tongdu is used in treatment of lumbar spinal stenosis and lumbosacral disc herniations, but has some adverse side-effects on liver." ;
rdfs:subClassOf obo:XCO_0001623 .
obo:XCO_0001008 a rdfs:Class ;
rdfs:label "transfer of Pum2 shRNA using a lentivirus vector" ;
rdfs:comment "This is any condition in which the main influencing factor is Pum2 (pumilio RNA-binding family member 2) shRNA. Pum2 is a protein that exhibits lncRNA binding, miRNA binding, and mRNA 3'-UTR binding. Pum2 is involved in negative regulation of gene expression and regulation of intracellular mRNA localization." ;
rdfs:subClassOf obo:XCO_0001537 .
obo:XCO_0001627 a rdfs:Class ;
rdfs:label "polysorbate 20" ;
rdfs:comment "This is any condition in which the main influencing factor is polysorbate 20, a nonionic surfactant and detergent widely used in various applications, including biochemical and life science research, food production, and personal care products. Polysorbate 20 is a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group." ;
rdfs:subClassOf obo:XCO_0001167 .
obo:XCO_0000065 a rdfs:Class ;
rdfs:label "hand dynamometer activity" ;
rdfs:comment "The action of squeezing an apparatus that measures the muscular contraction of the hand, used as a condition of exertion in experiments measuring other physiological functions." ;
rdfs:subClassOf obo:XCO_0000059 .
obo:XCO_0001088 a rdfs:Class ;
rdfs:label "cefuroxime" ;
rdfs:comment "This is any condition in which the main influencing factor is cefuroxime, a broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. Cefuroxime has been proposed for treatment of infections of gram-negative organisms, gram-positive organisms, gonorrhea, and haemophilus." ;
rdfs:subClassOf obo:XCO_0000483 .
obo:XCO_0001256 a rdfs:Class ;
rdfs:label "total parenteral nutrition" ;
rdfs:comment "This is any condition in which the main influencing factor is total parenteral nutrition (TPN), a method of feeding that bypasses the gastrointestinal tract by using an intravenous route. Total parenteral nutrition exists when no significant nutrition is obtained by other routes." ;
rdfs:subClassOf obo:XCO_0000013 .
obo:XCO_0000216 a rdfs:Class ;
rdfs:label "ion channel activator" ;
rdfs:comment "Any chemical substance which increases the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane." ;
rdfs:subClassOf obo:XCO_0000214 .
obo:XCO_0001586 a rdfs:Class ;
rdfs:label "2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester" ;
rdfs:comment "This is any condition in which the main influencing factor is 2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester, an indolyl carboxylic acid." ;
rdfs:subClassOf obo:XCO_0000511 .
obo:XCO_0001048 a rdfs:Class ;
rdfs:label "scrambled gapmer antisense oligonucleotide" ;
rdfs:comment "This is any condition in which the main influencing factor is a negative control gapmer. A negative control gapmer is a gapmer with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental gapmer used." ;
rdfs:subClassOf obo:XCO_0000585 .
obo:XCO_0000104 a rdfs:Class ;
rdfs:label "glucose solution, 2.8M" ;
rdfs:comment "A mixture in which 2.8 moles of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout a sufficient volume of another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level and the final volume is one liter." ;
rdfs:subClassOf obo:XCO_0000103 .
obo:XCO_0000487 a rdfs:Class ;
rdfs:label "Streptococcus pneumoniae TIGR4 LuxS mutant" ;
rdfs:comment "A condition in which the primary influencing factor is the LuxS mutant of Streptococcus pneumoniae TIGR4." ;
rdfs:subClassOf obo:XCO_0000478 .
obo:XCO_0001444 a rdfs:Class ;
rdfs:label "muscle layer pouch" ;
rdfs:comment "This is any condition in which the main influencing factor is an artificial pouch created by a surgical technique to cover a ligament wound with the adjacent muscle layer. The pouch may be used for delivery of drugs or other agents." ;
rdfs:subClassOf obo:XCO_0000318 .
obo:XCO_0001858 a rdfs:Class ;
rdfs:label "molar ligation" ;
rdfs:comment "This is any condition in which the main influencing factor is molar ligation, a procedure in which a suture ligature is placed around a molar. It is used as a model of experimentally induced periodontitis." ;
rdfs:subClassOf obo:XCO_0001100 .
obo:XCO_0000162 a rdfs:Class ;
rdfs:label "pentolinium" ;
rdfs:comment "Nicotinic acetylcholine receptor antagonist, ganglionic blocking agent and vasodilator which consists of a dication whose structure comprises a pentane backbone linking two 1-methylpyrrolidinium groups." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000160 .
obo:XCO_0001035 a rdfs:Class ;
rdfs:label "controlled HTE content drinking water" ;
rdfs:comment "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of hawk tea extract consumed by an organism as part of an experiment. Hawk tea extract is a potential cholesterol-lowering agent and antioxidant. Hawk tea is a traditional herbal and caffeine-free drink popular in China." ;
rdfs:subClassOf obo:XCO_0000163 .
obo:XCO_0001667 a rdfs:Class ;
rdfs:label "cyclo(L-His-L-Pro)" ;
rdfs:comment "This is any condition in which the main influencing factor is cyclo(L-His-L-Pro), a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH)." ;
rdfs:subClassOf obo:XCO_0000193 .
obo:XCO_0001319 a rdfs:Class ;
rdfs:label "3D printed scaffold implantation" ;
rdfs:comment "This is any condition in which the main influencing factor is implantation of a 3D printed scaffold, an artificial construct which mimics the extracellular matrix of the host tissue. The scaffold may be made of natural or synthetic polymers, metal, or ceramic." ;
rdfs:subClassOf obo:XCO_0001409 .
obo:XCO_0001167 a rdfs:Class ;
rdfs:label "polysorbate" ;
rdfs:comment "This is any condition in which the main influencing factor is any poly(ethylene glycol) derivative composed of PEG-ylated sorbitan [2-(1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol] normally containing a total of 20 oxyethylene groups, with one or more of the terminal hydroxy groups esterified with a fatty acyl group. They are used as emulsifiers and dispersing agents in some pharmaceuticals products and as defoamers and emulsifiers in some foods." ;
rdfs:subClassOf obo:XCO_0001232 .
obo:XCO_0000424 a rdfs:Class ;
rdfs:label "benfotiamine" ;
rdfs:comment "A condition in which the main influencing factor is benfotiamine, a synthetic thioester S-acyl derivative and analogue of thiamine (vitamin B1); used as an antioxidant dietary supplement." ;
rdfs:subClassOf obo:XCO_0000271 .
obo:XCO_0000143 a rdfs:Class ;
rdfs:label "acetylcholine" ;
rdfs:comment "An organic, polyatomic cation, formed as an ester of acetic acid and choline, that acts as a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms." ;
rdfs:subClassOf obo:XCO_0000140 , obo:XCO_0000144 .
obo:XCO_0001095 a rdfs:Class ;
rdfs:label "FYT tea infusion" ;
rdfs:comment "This is any condition in which the main influencing factor is FYT, a common green tea variety called Camellia sinensis (L.) O. Kuntze cv. Fuyun6." ;
rdfs:subClassOf obo:XCO_0000075 .
obo:XCO_0000913 a rdfs:Class ;
rdfs:label "ethosuximide" ;
rdfs:comment "Any condition in which the main influencing factor is ethosuximide, a dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. Ethosuximide is an antiepileptic used in the treatment of absence seizures and potentially myoclonic seizures, but is ineffective against tonic-clonic seizures." ;
rdfs:subClassOf obo:XCO_0000269 .
obo:XCO_0000682 a rdfs:Class ;
rdfs:label "Benfluorex" ;
rdfs:comment "A benzoate ester that has formula C19H20F3NO2. Functionally, it is an anorectic and hypolipidemic agent." ;
rdfs:subClassOf obo:XCO_0000511 , obo:XCO_0000680 .
obo:XCO_0001847 a rdfs:Class ;
rdfs:label "ladder climbing with weights" ;
rdfs:comment "This is any condition in which the main influencing factor is ladder climbing (the act of ascending or descending a structure that consists essentially of two long sidepieces joined at intervals by crosspieces on which one may step) while carrying weights to increase resistance, thereby increasing the difficulty of the action." ;
rdfs:subClassOf obo:XCO_0001846 .
obo:XCO_0001533 a rdfs:Class ;
rdfs:label "sciatic nerve ablation" ;
rdfs:comment "This is any condition in which the main influencing factor is sciatic nerve ablation, surgical removal of some part of the sciatic nerve." .
obo:XCO_0000987 a rdfs:Class ;
rdfs:label "gene transfer of the rat wild type Ccny gene and EGFP gene using a lentivirus vector" ;
rdfs:comment "This is a condition in which the rat wild type cyclin Y gene (Ccny-WT) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism." ;
rdfs:subClassOf obo:XCO_0000983 , obo:XCO_0000984 .
obo:XCO_0000851 a rdfs:Class ;
rdfs:label "stem cells" ;
rdfs:comment "This is a condition in which the main influencing factor is a stem cell, an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions." ;
rdfs:subClassOf obo:XCO_0000761 .
obo:XCO_0001178 a rdfs:Class ;
rdfs:label "methimazole" ;
rdfs:comment "This is any condition in which the main influencing factor is methimazole, a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin through inhibition of the peroxidase enzyme." ;
rdfs:subClassOf obo:XCO_0000523 .
obo:XCO_0001709 a rdfs:Class ;
rdfs:label "pregestational maternal exposure to enolase 2 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any pregestational maternal exposure to an autoantibody-generating level of enolase 2 (ENO2) multiple antigenic peptides (MAPs). This is a condition typically studied to determine the effect of maternal (F0) ENO2 exposure on the F1 offspring." ;
rdfs:subClassOf obo:XCO_0001708 .
obo:XCO_0001402 a rdfs:Class ;
rdfs:label "21% O2, 79% N2" ;
rdfs:comment "This is a condition in which the level of oxygen (21%) and nitrogen (79%) in the air surrounding the organism or breathed by the organism is controlled as part of the experiment." ;
rdfs:subClassOf obo:XCO_0000010 , obo:XCO_0001403 .
obo:XCO_0000111 a rdfs:Class ;
rdfs:label "temperature exposure" ;
rdfs:subClassOf obo:XCO_0000000 .
obo:XCO_0001702 a rdfs:Class ;
rdfs:label "multigenerational maternal exposure to collapsin response mediator protein 2 MAPs" ;
rdfs:comment "This is any condition in which the main influencing factor is any maternal exposure to an autoantibody-generating level of collapsin response mediator protein 2 (CRMP2) multiple antigenic peptides (MAPs) that has multigenerational effects. This is a condition typically studied to determine the effect of a maternal (F0) CRMP2 exposure on the F1 offspring, but can also affect the F2 generation by direct effects on the germline of the gestating or preweaning F1 offspring. The maternal exposure may be any time before pregnancy (pregestational) up to the time of weaning of offspring." ;
rdfs:subClassOf obo:XCO_0001724 .
obo:XCO_0000193 a rdfs:Class ;
rdfs:label "peptide/protein" ;
rdfs:comment "Any natural or synthetic complex organic macromolecule composed of chain(s) of amino acids. A peptide can be contain as few as two amino acids; a protein can contain multiple chains composed of hundreds of amino acids." ;
rdfs:subClassOf obo:XCO_0000342 .
obo:XCO_0001032 a rdfs:Class ;
rdfs:label "human neural progenitor cells" ;
rdfs:comment "This is any condition in which the main influencing factor is neural progenitor cells, which are isolated from embryonic or fetal CNS tissue and can be expanded in culture for prolonged periods using genetic or epigenetic approaches. Expanded cells have the capacity to differentiate into neurons, oligodendrocytes, or astrocytes." ;
rdfs:subClassOf obo:XCO_0001393 .
obo:XCO_0001372 a rdfs:Class ;
rdfs:label "TEBV implantation sham procedure" ;
rdfs:comment "This is any condition in which the main influencing factor is TEBV implantation sham surgery, which follows the same surgical process as a TEBV implantation without the replacement of a blood vessel with a tissue-engineered blood vessel." ;
rdfs:subClassOf obo:XCO_0000100 .
obo:XCO_0000617 a rdfs:Class ;
rdfs:label "quinidine" ;
rdfs:comment "This is any condition in which the main influencing factor is quinidine, a stereoisomer of quinine which dampens the excitability of cardiac and skeletal muscles by blocking voltage-gated sodium channels and potassium channels. Quinidine prolongs action potentials, blocks muscarinic and alpha-adrenergic neurotransmission, and inhibits multiple enzymes." ;
rdfs:subClassOf obo:XCO_0000225 , obo:XCO_0000336 , obo:XCO_0000523 , obo:XCO_0000618 , obo:XCO_0000630 .
obo:XCO_0001149 a rdfs:Class ;
rdfs:label "clozapine" ;
rdfs:comment "This is any condition whose main influencing factor is clozapine, a tricylic dibenzodiazepinethat binds several types of central nervous system receptors. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor." ;
rdfs:subClassOf obo:XCO_0000160 .
obo:BFO_0000051 a rdf:Property ;
rdfs:label "has_part" ;
rdfs:range .
obo:IAO_0000115 a rdf:Property ;
rdfs:label "definition" ;
rdfs:range xsd:string .