PREFIX obo: <http://purl.obolibrary.org/obo/>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

obo:BFO_0000019 a rdfs:Class ;
  rdfs:label "quality"@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:BFO_0000051 a rdf:Property ;
  rdfs:label "has part" ;
  rdfs:comment "a core relation that holds between a whole and its part"@en ;
  rdfs:range obo:BFO_0000020 , <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:BFO_0000050 a rdf:Property ;
  rdfs:label "part of" ;
  rdfs:comment "a core relation that holds between a part and its whole"@en ;
  rdfs:seeAlso <http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections> , <http://ontologydesignpatterns.org/wiki/Submissions:PartOf> , <http://www.obofoundry.org/ro/#OBO_REL:part_of> ;
  rdfs:range obo:BFO_0000019 , obo:BFO_0000017 , obo:BFO_0000031 , obo:BFO_0000004 , obo:BFO_0000015 , obo:BFO_0000020 , obo:BFO_0000002 , obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002506 a rdf:Property ;
  rdfs:label "causal relation between entities" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:SEPIO_0000036 a rdf:Property ;
  rdfs:label "date_modified"@en ;
  rdfs:comment "The date that a particular resource or artifact was last modified or updated." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range xsd:dateTime ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/date> .

<http://purl.org/dc/terms/date> a rdf:Property ;
  rdfs:label "date"@en ;
  rdfs:comment "A point or period of time associated with an event in the lifecycle of an information entity or  resource." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range xsd:dateTime .

obo:RO_0002566 a rdf:Property ;
  rdfs:label "causally influences" ;
  rdfs:comment "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002506 .

obo:SEPIO_0000051 a rdf:Property ;
  rdfs:label "date_submitted"@en ;
  rdfs:comment "The date that a particular resource or artifact was formally submitted to be reviewed and/or included in some larger resource (e.g. database, registry, collection, etc.)." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range xsd:dateTime ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/date> .

obo:SEPIO_0000040 a rdf:Property ;
  rdfs:label "date_evaluated"@en ;
  rdfs:comment "The date that a particular resource or artifact was last evaluated -  typically to assess its quality, completeness, accuracy, conformance, etc." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range xsd:dateTime ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/date> .

obo:RO_0002258 a rdf:Property ;
  rdfs:label "developmentally preceded by"@en ;
  rdfs:comment "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002324 .

obo:RO_0000056 a rdf:Property ;
  rdfs:label "participates in"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000003 .

obo:BFO_0000034 a rdfs:Class ;
  rdfs:label "function"@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:RO_0004028 a rdf:Property ;
  rdfs:label "realized in response to stimulus" ;
  rdfs:comment "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0000079 a rdf:Property ;
  rdfs:label "function of"@en ;
  rdfs:comment "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000034 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:BFO_0000054 a rdf:Property ;
  rdfs:label "realized in"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000015 .

obo:RO_0009501 a rdf:Property ;
  rdfs:label "realized in response to"@en ;
  rdfs:comment "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." ;
  rdfs:seeAlso <https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit> ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:BFO_0000017 a rdfs:Class ;
  rdfs:label "realizable entity"@en ;
  rdfs:comment "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:SEPIO_0000056 a rdfs:Class ;
  rdfs:label "obsolete_automated assertion process"@en ;
  rdfs:comment "An assertion process performed through algorithmic analysis by a computational agent, independent of human review." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_000383 a rdfs:Class ;
  rdfs:label "record" ;
  rdfs:comment "A document containing a collection of data or statements about some entity." ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:SEPIO_0000167 a rdf:Property ;
  rdfs:label "has_confidence_level"@en ;
  rdfs:comment "A relation between an information entity and an indicator of degree of confidence that the information it represents is true." ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range obo:SEPIO_0000187 .

obo:SEPIO_0000415 a rdf:Property ;
  rdfs:label "information_quality" ;
  rdfs:comment "A relation describing the quality of a piece of information, wich may or may not be used as evidence by an agent making an assertion." ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000168 a rdf:Property ;
  rdfs:label "has_confidence_score"@en ;
  rdfs:comment "A quantitative value that can be interpreted as an indicator of the degree of confidence that a piece of information is true, and accurately reflects the aspect of reality it is about." ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000109 a rdf:Property ;
  rdfs:label "expresses"@en ;
  rdfs:comment "Relationship between a document (e.g. a publication, report, database record) and an assertion or proposition that is stated in its content." ;
  rdfs:domain obo:IAO_0000310 ;
  rdfs:range xsd:string .

obo:SEPIO_0000387 a rdf:Property ;
  rdfs:label "created_by"@en ;
  rdfs:comment "A relation between a particular information resource / digital artifact and an agent who made a primary contribution to its original creation." ;
  rdfs:range <http://www.w3.org/ns/prov#Agent> ;
  rdfs:subPropertyOf obo:SEPIO_0000150 .

obo:IAO_0000136 a rdf:Property ;
  rdfs:label "is about" ;
  rdfs:comment "Is_about is a (currently) primitive relation that relates an information artifact to an entity." ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000181 a rdfs:Class ;
  rdfs:label "obsolete_evidence data"@en ;
  rdfs:comment "Research data, or a product derived from research data such as data sets or figures, that are used as evidence to evaluate the validity of a target assertion or proposition." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_0000157 a rdfs:Class ;
  rdfs:label "obsolete software agent" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_0000049 a rdfs:Class ;
  rdfs:label "resource role"@en ;
  rdfs:comment "A role inhering in any material or information artifact that is used by an agent as specified input into a planned process." ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:IAO_0000313 a rdfs:Class ;
  rdfs:label "patent"@en ;
  rdfs:comment "A document that has been accepted by a patent authority"@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:IAO_0000013 a rdfs:Class ;
  rdfs:label "journal article"@en ;
  rdfs:comment "a report that is published in a journal"@en ;
  rdfs:subClassOf obo:IAO_0000311 .

obo:COB_0000122 a rdfs:Class ;
  rdfs:label "physical information carrier" ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:RO_0002450 a rdf:Property ;
  rdfs:label "directly positively regulates activity of" ;
  rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002448 .

obo:RO_0002449 a rdf:Property ;
  rdfs:label "directly negatively regulates activity of" ;
  rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002448 .

obo:RO_0002448 a rdf:Property ;
  rdfs:label "directly regulates activity of" ;
  rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.

A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011002 , obo:RO_0002436 .

obo:RO_0011002 a rdf:Property ;
  rdfs:label "regulates activity of" ;
  rdfs:comment "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002566 .

obo:RO_0000087 a rdf:Property ;
  rdfs:label "has role"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000023 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0002215 a rdf:Property ;
  rdfs:label "capable of" ;
  rdfs:comment "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process" ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002216 .

obo:RO_0000085 a rdf:Property ;
  rdfs:label "has function"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000034 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0002595 a rdf:Property ;
  rdfs:label "causal relation between material entity and a process" ;
  rdfs:comment "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0000091 a rdf:Property ;
  rdfs:label "has disposition"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000016 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0002434 a rdf:Property ;
  rdfs:label "interacts with" ;
  rdfs:comment "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/interaction-relations/> ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0002202 a rdf:Property ;
  rdfs:label "develops from"@en ;
  rdfs:comment "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:SEPIO_0000414 a rdfs:Class ;
  rdfs:label "evidence quality" ;
  rdfs:comment "A data item that indicates the quality of the data used as evidence by an agent making an assertion." ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:SEPIO_0000074 a rdfs:Class ;
  rdfs:label "in vivo study"@en ;
  rdfs:subClassOf obo:SEPIO_0000072 .

obo:BFO_0000062 a rdf:Property ;
  rdfs:label "preceded by"@en ;
  rdfs:comment "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002086 .

obo:RO_0002234 a rdf:Property ;
  rdfs:label "has output"@en ;
  rdfs:comment "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:BFO_0000063 a rdf:Property ;
  rdfs:label "precedes"@en ;
  rdfs:comment "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002501 a rdf:Property ;
  rdfs:label "causal relation between processes" ;
  rdfs:comment "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:SEPIO_0000063 a rdf:Property ;
  rdfs:label "start_date"@en ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range xsd:dateTime ;
  rdfs:subPropertyOf obo:SEPIO_0000160 .

obo:COB_0000081 a rdf:Property ;
  rdfs:label "intended to realize" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0019000 a rdf:Property ;
  rdfs:label "regulates characteristic" ;
  rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:PATO_0000001 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002233 a rdf:Property ;
  rdfs:label "has input"@en ;
  rdfs:comment "p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:OBI_0000293 a rdf:Property ;
  rdfs:label "has specified input"@en ;
  rdfs:domain obo:OBI_0000011 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0002018 a rdf:Property ;
  rdfs:label "has component process" ;
  rdfs:comment "w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002180 .

obo:SEPIO_0000017 a rdf:Property ;
  rdfs:label "has_agent"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range <http://www.w3.org/ns/prov#Agent> ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:OBI_0000299 a rdf:Property ;
  rdfs:label "has specified output"@en ;
  rdfs:domain obo:OBI_0000011 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:BFO_0000055 a rdf:Property ;
  rdfs:label "realizes" ;
  rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000017 .

obo:RO_0000057 a rdf:Property ;
  rdfs:label "has participant" ;
  rdfs:comment "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000002 .

obo:COB_0000087 a rdf:Property ;
  rdfs:label "realizes" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000017 .

obo:RO_0002211 a rdf:Property ;
  rdfs:label "regulates"@en ;
  rdfs:comment "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002411 .

obo:RO_0002222 a rdf:Property ;
  rdfs:label "temporally related to"@en ;
  rdfs:comment "A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 .

obo:RO_0002334 a rdf:Property ;
  rdfs:label "regulated by"@en ;
  rdfs:comment "inverse of regulates" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002427 .

obo:SEPIO_0000160 a rdf:Property ;
  rdfs:label "activity_date"@en ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range xsd:dateTime .

obo:BFO_0000182 a rdfs:Class ;
  rdfs:label "history" ;
  rdfs:comment "A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001])" ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:SEPIO_0000079 a rdfs:Class ;
  rdfs:label "secondary research study"@en ;
  rdfs:comment "A study based only on analysis of existing data, as found in artifacts such as community/curated databases, raw datasets, or publications." ;
  rdfs:subClassOf obo:SEPIO_0000125 .

obo:CARO_0000000 a rdfs:Class ;
  rdfs:label "anatomical entity" ;
  rdfs:comment "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex.  Or, a substance produced by a cellular organism with granularity above the level of a protein complex." ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:RO_0002254 a rdf:Property ;
  rdfs:label "has developmental contribution from"@en ;
  rdfs:comment "x has developmental contribution from y iff x has some part z such that z develops from y"@en ;
  rdfs:domain obo:CARO_0000000 ;
  rdfs:range obo:CARO_0000000 ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:RO_0002384 a rdf:Property ;
  rdfs:label "has developmental potential involving"@en ;
  rdfs:comment "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)."@en ;
  rdfs:domain obo:CARO_0000000 ;
  rdfs:range obo:CARO_0000000 ;
  rdfs:subPropertyOf obo:RO_0002324 .

obo:STATO_0000039 a rdfs:Class ;
  rdfs:label "statistic"@en ;
  rdfs:comment "a statistic is a measurement datum to describe a dataset or a variable. It is generated by a calculation on set of observed data."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:SEPIO_0000175 a rdfs:Class ;
  rdfs:label "obsolete_observation"@en ;
  rdfs:comment "A statement describing something that was observed or recorded." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_0000173 a rdfs:Class ;
  rdfs:label "study finding"@en ;
  rdfs:comment "A statement describing the immediate results of a research study, describing what was directly observed, measured, or derived through mathematical calculation." ;
  rdfs:subClassOf obo:SEPIO_0000174 .

obo:SEPIO_0000257 a rdf:Property ;
  rdfs:label "describes_study_data" ;
  rdfs:comment "A relation that holds between a study finding and a data item it describes (i.e. a data item generated by the study whose results are described by the finding)." ;
  rdfs:domain obo:SEPIO_0000173 ;
  rdfs:range obo:IAO_0000030 ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:SEPIO_0000130 a rdf:Property ;
  rdfs:label "authored_by"@en ;
  rdfs:comment "A relation between an information content entity (or concrete manifestation of it as a particular resource/digital artifact), and the agent that originally generated the information content." ;
  rdfs:range <http://www.w3.org/ns/prov#Agent> ;
  rdfs:subPropertyOf obo:SEPIO_0000150 .

obo:RO_0002353 a rdf:Property ;
  rdfs:label "output of"@en ;
  rdfs:comment "inverse of has output" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000056 .

obo:SEPIO_0000108 a rdf:Property ;
  rdfs:label "is_expressed_in"@en ;
  rdfs:comment "Relationship between a statement or proposition and a document in which it is expressed (e.g. a publication, report, or database record)." ;
  rdfs:range obo:IAO_0000310 .

obo:SEPIO_0000144 a rdf:Property ;
  rdfs:label "has_qualifier"@en ;
  rdfs:comment "A relation used to indicate context in which a particular assertion or proposition applies." ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:ERO_0001716 a rdfs:Class ;
  rdfs:label "database"@en ;
  rdfs:comment "A database is an organized collection of data, today typically in digital form." ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:SEPIO_0000149 a rdfs:Class ;
  rdfs:label "evidence item"@en ;
  rdfs:comment "An information content entity that is used as evidence to evaluate the validity of a target assertion or proposition." ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:SEPIO_0000046 a rdf:Property ;
  rdfs:label "has_role"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000376 a rdf:Property ;
  rdfs:label "evidence_item_for" ;
  rdfs:domain obo:SEPIO_0000149 ;
  rdfs:range obo:SEPIO_0000002 .

obo:SEPIO_0000002 a rdfs:Class ;
  rdfs:label "evidence line"@en ;
  rdfs:comment "An evidence line represents an independent and meaningful argument for or against a particular proposition, that is based on the interpretation of one or more pieces of information as evidence." ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:SEPIO_0000429 a rdf:Property ;
  rdfs:label "evidence_line_strength_score"@en ;
  rdfs:comment "A numerical value that quantifies the strength of evidence provided by a line of evidence. This is a counterpart to the evidence_line_strength object property - for use when the strength of evidence is captured using a quantitiative score/measure." ;
  rdfs:domain obo:SEPIO_0000002 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000085 a rdf:Property ;
  rdfs:label "evidence_has_supporting_activity"@en ;
  rdfs:comment "A relation that links an evidence line to any activities (studies, assays, computational tasks, curation) that generated evidence items contributing to it." ;
  rdfs:domain obo:SEPIO_0000002 ;
  rdfs:range <http://www.w3.org/ns/prov#Activity> ;
  rdfs:subPropertyOf obo:RO_0002614 .

obo:SEPIO_0000124 a rdf:Property ;
  rdfs:label "evidence_has_supporting_reference"@en ;
  rdfs:comment "A relation that holds between an evidence line and a citable document from which information supporting the evidence line was obtained (i.e. a \"supporting reference\")." ;
  rdfs:domain obo:SEPIO_0000002 ;
  rdfs:range obo:IAO_0000310 ;
  rdfs:subPropertyOf obo:RO_0002614 .

obo:RO_0002614 a rdf:Property ;
  rdfs:label "is_evidence_with_support_from" ;
  rdfs:comment "A relationship between a piece of evidence and an entity that plays a role in supporting that evidence." ;
  rdfs:domain obo:SEPIO_0000002 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002616 .

obo:SEPIO_0000084 a rdf:Property ;
  rdfs:label "has_evidence_item"@en ;
  rdfs:comment "A relation holding between an evidence line and an individual information entity that contributes to the argument it represents." ;
  rdfs:domain obo:SEPIO_0000002 ;
  rdfs:range obo:SEPIO_0000149 ;
  rdfs:subPropertyOf obo:RO_0002614 .

obo:SEPIO_0000132 a rdf:Property ;
  rdfs:label "evidence_line_strength"@en ;
  rdfs:comment "A relation describing the degree of support provided by an evidence line for a target assertion or proposition." ;
  rdfs:domain obo:SEPIO_0000002 ;
  rdfs:range obo:SEPIO_0000133 .

obo:SEPIO_0000183 a rdf:Property ;
  rdfs:label "evidence_direction"@en ;
  rdfs:comment "A relation indicating whether an evidence line supports or disputes a target proposition (or represents inconclusive evidence that is not sufficient for either)." ;
  rdfs:domain obo:SEPIO_0000002 ;
  rdfs:range obo:SEPIO_0000402 .

obo:SEPIO_0000080 a rdfs:Class ;
  rdfs:label "literature-based study"@en ;
  rdfs:comment "A curation-based study that uses only one or more literature publication as input data source." ;
  rdfs:subClassOf obo:SEPIO_0000079 .

obo:COB_0000119 a rdfs:Class ;
  rdfs:label "evaluant role" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:SEPIO_0000143 a rdfs:Class ;
  rdfs:label "patient case study" ;
  rdfs:comment "A study that documents observations or findings from a single patent." ;
  rdfs:subClassOf obo:SEPIO_0000066 .

obo:SEPIO_0000186 a rdfs:Class ;
  rdfs:label "patient phenotyping study"@en ;
  rdfs:comment "A study with the goal of assessing and documenting phenotypes exhibited by one or more patients." ;
  rdfs:subClassOf obo:SEPIO_0000070 .

<http://www.w3.org/2003/11/swrl#Variable> a rdfs:Class .

obo:IAO_0000308 a rdfs:Class ;
  rdfs:label "figure"@en ;
  rdfs:comment "An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:BFO_0000040 a rdfs:Class ;
  rdfs:label "material entity"@en ;
  rdfs:comment "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:SEPIO_0000153 a rdfs:Class ;
  rdfs:label "creator role"@en ;
  rdfs:subClassOf obo:SEPIO_0000048 .

obo:OBI_0000938 a rdfs:Class .

obo:OBI_0000070 a rdfs:Class ;
  rdfs:label "assay"@en ;
  rdfs:subClassOf obo:SEPIO_0000004 .

obo:SEPIO_0000400 a rdfs:Class ;
  rdfs:label "study data set"@en ;
  rdfs:comment "A data set comprised of data items produced by a single research study." ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:COB_0000121 a rdfs:Class ;
  rdfs:label "measurement datum" ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:SEPIO_0000055 a rdfs:Class ;
  rdfs:label "obsolete_manual assertion process"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:IAO_0000100 a rdfs:Class ;
  rdfs:label "data set"@en ;
  rdfs:comment "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:BFO_0000023 a rdfs:Class ;
  rdfs:label "role"@en ;
  rdfs:comment "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts."@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:SEPIO_0000078 a rdfs:Class ;
  rdfs:label "organism-based in vivo study"@en ;
  rdfs:subClassOf obo:SEPIO_0000074 .

obo:GO_0008150 a rdfs:Class ;
  rdfs:label "biological_process" ;
  rdfs:comment "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." .

obo:STATO_0000104 a rdfs:Class ;
  rdfs:label "z-score"@en ;
  rdfs:comment "A z-score (also known as z-value, standard score, or normal score) is a measure of the divergence of an individual experimental result from the most probable result, the mean. Z is expressed in terms of the number of standard deviations from the mean value."@en ;
  rdfs:subClassOf obo:STATO_0000039 .

obo:GO_0003674 a rdfs:Class ;
  rdfs:label "molecular_function" ;
  rdfs:comment "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." .

obo:BFO_0000016 a rdfs:Class ;
  rdfs:label "disposition"@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:IAO_0000030 a rdfs:Class ;
  rdfs:label "information" ;
  rdfs:comment "A generically dependent continuant that is about some thing." ;
  rdfs:subClassOf obo:BFO_0000031 .

obo:SEPIO_0000070 a rdfs:Class ;
  rdfs:label "observational clinical study"@en ;
  rdfs:subClassOf obo:SEPIO_0000067 .

obo:SEPIO_0000340 a rdfs:Class ;
  rdfs:label "skos terms" ;
  rdfs:comment "Organizational class that groups classes imported from the skos model to support creation and definition of value sets for particular SEPIO data model implementations." .

obo:SEPIO_0000156 a rdfs:Class ;
  rdfs:label "curator role"@en ;
  rdfs:subClassOf obo:SEPIO_0000048 .

obo:OBI_0000272 a rdfs:Class ;
  rdfs:label "protocol" ;
  rdfs:comment "A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process." ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:SEPIO_0000407 a rdf:Property ;
  rdfs:label "specified_creation_of"@en ;
  rdfs:comment "A relation holding between a plan specification and a planned process it specifies, or the artifact the process generates." ;
  rdfs:domain obo:IAO_0000104 ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://www.w3.org/ns/prov#SoftwareAgent> a rdfs:Class ;
  rdfs:label "SoftwareAgent"@en ;
  rdfs:comment "A software agent is running software." ;
  rdfs:subClassOf <http://www.w3.org/ns/prov#Agent> .

obo:SEPIO_0000125 a rdfs:Class ;
  rdfs:label "research study"@en ;
  rdfs:comment "A planned process that executes some study design or protocol to generate scientific data that is interpreted to test or generate a hypothesis." ;
  rdfs:subClassOf obo:SEPIO_0000004 .

obo:OBI_0000338 a rdfs:Class ;
  rdfs:label "drawing a conclusion based on data"@en ;
  rdfs:comment "A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion"@en ;
  rdfs:subClassOf obo:SEPIO_0000003 .

obo:BFO_0000001 a rdfs:Class ;
  rdfs:label "entity"@en .

obo:SEPIO_0000003 a rdfs:Class ;
  rdfs:label "assertion process"@en ;
  rdfs:comment "An act of interpreting evidence to make an assertion of belief that a particular proposition is true" ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0000260 a rdfs:Class ;
  rdfs:label "plan"@en ;
  rdfs:subClassOf obo:BFO_0000017 , obo:COB_0000120 .

obo:COB_0000078 a rdf:Property ;
  rdfs:label "concretizes" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:COB_0000082 a rdfs:Class ;
  rdfs:label "planned process" ;
  rdfs:comment "A process that is initiated by an agent who intends to carry out a plan to achieve an objective through one or more actions as described in a plan specification." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:SEPIO_0000081 a rdfs:Class ;
  rdfs:label "curation-based study"@en ;
  rdfs:subClassOf obo:SEPIO_0000079 .

obo:IAO_0000088 a rdfs:Class ;
  rdfs:label "report"@en ;
  rdfs:comment "a document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record)"@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:BFO_0000004 a rdfs:Class ;
  rdfs:label "independent continuant"@en ;
  rdfs:comment "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:BFO_0000015 a rdfs:Class ;
  rdfs:label "process"@en ;
  rdfs:comment "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:SEPIO_0000148 a rdfs:Class ;
  rdfs:label "evidence role"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:SEPIO_0000067 a rdfs:Class ;
  rdfs:label "clinical study"@en ;
  rdfs:comment "Formal clinical study performed using cohorts of multiple patients" ;
  rdfs:subClassOf obo:SEPIO_0000066 .

<http://www.w3.org/ns/prov#Activity> a rdfs:Class ;
  rdfs:label "Activity" ;
  rdfs:comment "An activity is something that occurs over a period of time and acts upon or with entities; it may include consuming, processing, transforming, modifying, relocating, using, or generating entities." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:SEPIO_0000133 a rdfs:Class ;
  rdfs:label "evidence strength"@en ;
  rdfs:comment "A data item that quantifies the degree of support an agent believes an evidence line to provide for a particular proposition." ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:IAO_0000104 a rdfs:Class ;
  rdfs:label "plan specification" ;
  rdfs:comment "A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:SEPIO_0000071 a rdfs:Class ;
  rdfs:label "case-control clinical study"@en ;
  rdfs:subClassOf obo:SEPIO_0000070 .

obo:OBI_0000011 a rdfs:Class ;
  rdfs:label "completely executed planned process"@en ;
  rdfs:comment "A processual entity that realizes a plan which is the concretization of a plan specification."@en ;
  rdfs:subClassOf obo:COB_0000082 , <http://www.w3.org/ns/prov#Activity> .

obo:SEPIO_0000155 a rdfs:Class ;
  rdfs:label "approver role"@en ;
  rdfs:subClassOf obo:SEPIO_0000154 .

obo:SEPIO_0000077 a rdfs:Class ;
  rdfs:label "tissue-based in vivo study"@en ;
  rdfs:subClassOf obo:SEPIO_0000074 .

obo:IAO_0000033 a rdfs:Class ;
  rdfs:label "directive information entity" ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:BFO_0000002 a rdfs:Class ;
  rdfs:label "continuant"@en ;
  rdfs:comment "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ;
  rdfs:subClassOf obo:BFO_0000001 .

obo:IAO_0000306 a rdfs:Class ;
  rdfs:label "table" ;
  rdfs:comment "A textual entity that contains a two-dimensional arrangement of texts repeated at regular intervals across a spatial range, such that the spatial relationships among the constituent texts expresses propositions" ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:COB_0000120 a rdfs:Class ;
  rdfs:label "information representation" ;
  rdfs:comment "Pier 'representational entity'" ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:SEPIO_0000432 a rdfs:Class ;
  rdfs:label "hypothesis"@en ;
  rdfs:comment "A hypothesis is another type of statement that, like an assertion, can be supported by evidence. It puts forward a possible fact as true, but does not express an agents belief in this fact.  Rather, it is a possible fact whose truth will be explored via reasoning or experimentation." ;
  rdfs:subClassOf obo:SEPIO_0000174 .

<http://xmlns.com/foaf/0.1/Group> a rdfs:Class ;
  rdfs:label "Group" ;
  rdfs:comment """The Group class represents a collection of individual agents (and may itself play the role of a Agent, ie. something that can perform actions).

This concept is intentionally quite broad, covering informal and ad-hoc groups, long-lived communities, organizational groups within a workplace, etc. Some such groups may have associated characteristics which could be captured in RDF (perhaps a homepage, name, mailing list etc.).""" ;
  rdfs:subClassOf <http://www.w3.org/ns/prov#Agent> .

obo:GO_0016301 a rdfs:Class ;
  rdfs:label "kinase activity" ;
  rdfs:comment "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." ;
  rdfs:subClassOf obo:GO_0003674 .

obo:IAO_0000064 a rdfs:Class ;
  rdfs:label "algorithm" ;
  rdfs:comment "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata." ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:SEPIO_0000258 a rdfs:Class ;
  rdfs:label "provider interpretation"@en ;
  rdfs:comment """Source: ClinVar (\" 'Provider interpretation' is intended for variants that were interpreted by a clinical provider. For example, the clinician may reclassify the variant using detailed patient phenotype information that was unavailable to the testing laborator\")
ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/release_notes/20170803_data_release_notes.pdf""" ;
  rdfs:subClassOf obo:SEPIO_0000070 .

obo:STATO_0000184 a rdfs:Class ;
  rdfs:label "obsolete_ratio" ;
  rdfs:comment "A ratio is a data item which is formed with two numbers r and s is written r/s, where r is the numerator and s is the denominator. The ratio of r to s is equivalent to the quotient r/s." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_0000401 a rdfs:Class ;
  rdfs:label "obsolete_opinion"@en ;
  rdfs:comment "A declarative sentence that expresses a belief or judgement that is not necessarily based on fact or knowledge." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

<http://www.w3.org/ns/prov#Person> a rdfs:Class ;
  rdfs:label "Person"@en ;
  rdfs:comment "Person agents are people." ;
  rdfs:subClassOf <http://www.w3.org/ns/prov#Agent> .

<http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> a rdfs:Class .

obo:IAO_0000311 a rdfs:Class ;
  rdfs:label "publication"@en ;
  rdfs:comment "A document that has been accepted by a publisher"@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0002165 a rdfs:Class ;
  rdfs:label "protein localization assay" ;
  rdfs:comment "An assay that determines the specific location of a protein. Subcellular localization is distinguished from tissue-based localization based on the type of microscopy applied." ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:SEPIO_0000000 a rdfs:Class ;
  rdfs:label "proposition"@en ;
  rdfs:comment "An abstract entity representing the sharable meaning of what is expressed in a particular assertion." ;
  rdfs:subClassOf obo:BFO_0000001 .

obo:SEPIO_0000189 a rdf:Property ;
  rdfs:label "has_evidence"@en ;
  rdfs:comment "A  relation that directly connects an assertion and an evidence item that contributes to one or more of its evidence  lines. This evidence provided by this item may support or dispute the target assertion." ;
  rdfs:range obo:SEPIO_0000149 .

obo:SEPIO_0000146 a rdf:Property ;
  rdfs:label "has_evidence_level"@en ;
  rdfs:comment "A relation used to link an assertion or proposition directly to some indicator of the strength of the total evidence that asserting agent beleives to support it." ;
  rdfs:range obo:SEPIO_0000133 .

obo:SEPIO_0000006 a rdf:Property ;
  rdfs:label "has_evidence_line"@en ;
  rdfs:comment "A relationship between an assertion or proposition and an evidence line used in evaluating its validity." ;
  rdfs:range obo:SEPIO_0000002 .

obo:SEPIO_0000100 a rdf:Property ;
  rdfs:label "strongly_contradicts"@en ;
  rdfs:comment "Relation between two propositions that make opposing claims (e.g. proposition1 holds that variant1 is pathogenic for disease1, and proposition2 holds that variant1 is benign for disease1)." ;
  rdfs:domain obo:SEPIO_0000000 ;
  rdfs:range obo:SEPIO_0000000 ;
  rdfs:subPropertyOf obo:SEPIO_0000115 .

obo:SEPIO_0000015 a rdf:Property ;
  rdfs:label "proposition_asserted_in" ;
  rdfs:comment "A relation holding between a proposition and an assertion in which it is expressed." ;
  rdfs:domain obo:SEPIO_0000000 ;
  rdfs:range obo:SEPIO_0000001 .

obo:SEPIO_0000145 a rdf:Property ;
  rdfs:label "has_evidence_from_source"@en ;
  rdfs:comment "A relation used to link an assertion or proposition to a source where evidence for it was found (i.e. a document, document part, database, etc)" ;
  rdfs:range obo:IAO_0000030 .

obo:OBI_0000066 a rdfs:Class ;
  rdfs:label "investigation"@en ;
  rdfs:comment "a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s)." ;
  rdfs:subClassOf obo:SEPIO_0000004 .

obo:BFO_0000020 a rdfs:Class ;
  rdfs:label "specifically dependent continuant"@en ;
  rdfs:comment "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en ;
  rdfs:seeAlso <https://github.com/OBOFoundry/COB/issues/65> , <https://github.com/oborel/obo-relations/pull/284> ;
  rdfs:subClassOf obo:BFO_0000002 .

<http://www.w3.org/ns/prov#Agent> a rdfs:Class ;
  rdfs:label "Agent" ;
  rdfs:comment "An agent is something that bears some form of responsibility for an activity taking place, for the existence of an entity, or for another agent's activity." ;
  rdfs:subClassOf obo:BFO_0000040 .

<http://purl.org/oban/association> a rdfs:Class ;
  rdfs:label "association"@en ;
  rdfs:comment "Associations are a form of proposition, framed as a tuple linking two (or more) entities through defined relationships." ;
  rdfs:subClassOf obo:SEPIO_0000000 .

<http://purl.org/oban/association_has_predicate> a rdf:Property ;
  rdfs:label "association has predicate"@en ;
  rdfs:domain <http://purl.org/oban/association> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:SEPIO_0000389 .

<http://purl.org/oban/association_has_subject> a rdf:Property ;
  rdfs:label "association has subject" ;
  rdfs:domain <http://purl.org/oban/association> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:SEPIO_0000388 .

<http://purl.org/oban/association_has_object> a rdf:Property ;
  rdfs:label "association has object" ;
  rdfs:domain <http://purl.org/oban/association> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:SEPIO_0000390 .

obo:SEPIO_0000385 a rdfs:Class ;
  rdfs:label "obsolete_method"@en ;
  rdfs:comment "An information content entity that specifies instructions for how a particular objective can be achieved." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_0000158 a rdfs:Class ;
  rdfs:label "contribution"@en ;
  rdfs:comment "The actions taken by a particular agent in the creation, modification, assessment, or deprecation of an artifact." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:SEPIO_0000169 a rdf:Property ;
  rdfs:label "performed_for"@en ;
  rdfs:comment "A relation between an agent and an other agent, typically an organization, on whose behalf a Contribution is made." ;
  rdfs:domain obo:SEPIO_0000158 ;
  rdfs:range <http://www.w3.org/ns/prov#Agent> .

obo:IAO_0000109 a rdfs:Class ;
  rdfs:label "measurement datum"@en ;
  rdfs:comment "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:COB_0000077 a rdfs:Class ;
  rdfs:label "action specification" ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:SEPIO_0000066 a rdfs:Class ;
  rdfs:label "primary research study"@en ;
  rdfs:comment "A study that involves primary research of subjects or specimens in a natural, cliniclal, or laboratory setting." ;
  rdfs:subClassOf obo:SEPIO_0000125 .

obo:IAO_0000102 a rdfs:Class ;
  rdfs:label "data about an ontology part"@en ;
  rdfs:comment "Data about an ontology part is a data item about a part of an ontology, for example a term"@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:SEPIO_0000187 a rdfs:Class ;
  rdfs:label "confidence level"@en ;
  rdfs:comment "A measurement datum that quantifies the level of confidence an agent has that a particular piece of information is true." ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:SEPIO_0000154 a rdfs:Class ;
  rdfs:label "assessor role"@en ;
  rdfs:subClassOf obo:SEPIO_0000048 .

obo:SEPIO_0000431 a rdfs:Class ;
  rdfs:label "recommendation"@en ;
  rdfs:comment "Recommendations are another type of statement besides assertions that can be supported by evidence. They don't put forth a proposed facts as true, but instead describe a recommended action on the foundation of evidence that it will be beneficial." ;
  rdfs:subClassOf obo:SEPIO_0000174 .

obo:SEPIO_0000127 a rdfs:Class ;
  rdfs:label "obsolete_study group"@en ;
  rdfs:comment "A group of individuals (organisms, specimens, samples) that are subjects in an observational or intervention study, and whose members represent experimental replicates as defined in a study design by the same independent variable specifications (i.e. subjected to the same selction criteria or set of experimental interventions)." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000235 a rdfs:Class ;
  rdfs:label "standard error"@en ;
  rdfs:comment "A quantitative confidence value which is the standard deviations of the sample in a frequency distribution, obtained by dividing the standard deviation by the total number of cases in the frequency distribution."@en ;
  rdfs:subClassOf obo:STATO_0000039 .

obo:SEPIO_0000037 a rdfs:Class ;
  rdfs:label "assertion method"@en ;
  rdfs:comment "A directive information entity that specifies an algorithm or heuristics for evaluating evidence in the process of making an assertion." ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:PATO_0000001 a rdfs:Class ;
  rdfs:label "quality" ;
  rdfs:comment "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:OBI_0001146 a rdfs:Class ;
  rdfs:label "binding assay" ;
  rdfs:comment "An assay with the objective to characterize the disposition of two or more material entities to form a complex." ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:SEPIO_0000048 a rdfs:Class ;
  rdfs:label "agent role" ;
  rdfs:comment "A role borne by a  person, group, organization, or information processing entity (e.g. software, algorithms) in virtue of its active participation in a process leading to some outcome (e.g the generation, modification, or provision of some entity)." ;
  rdfs:subClassOf obo:BFO_0000023 .

<http://www.w3.org/2004/02/skos/core#Concept> a rdfs:Class ;
  rdfs:label "Concept" ;
  rdfs:comment "An idea or notion; a unit of thought." ;
  rdfs:subClassOf obo:SEPIO_0000340 .

obo:SEPIO_0000102 a rdfs:Class ;
  rdfs:label "reference population data study"@en ;
  rdfs:comment "A study based on analysis of data gathered from baseline studies of a \tpopulation group of apparently unaffected individuals to assess allele frequencies" ;
  rdfs:subClassOf obo:SEPIO_0000079 .

<http://www.w3.org/ns/prov#Organization> a rdfs:Class ;
  rdfs:label "Organization"@en ;
  rdfs:comment "An organization is a social or legal institution such as a company, society, etc." ;
  rdfs:subClassOf <http://xmlns.com/foaf/0.1/Group> .

obo:SEPIO_0000072 a rdfs:Class ;
  rdfs:label "experimental model study"@en ;
  rdfs:comment "A research dtudy perfomred using an experimental model system such as a cell line, or model organism." ;
  rdfs:subClassOf obo:SEPIO_0000066 .

obo:SEPIO_0000004 a rdfs:Class ;
  rdfs:label "research activity"@en ;
  rdfs:comment "A planned process executed in the performance of scientific research wherein systematic investigations are performed to establish facts and reach new conclusions about phenomena in the world." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:BFO_0000003 a rdfs:Class ;
  rdfs:label "occurrent"@en ;
  rdfs:comment "An entity that has temporal parts and that happens, unfolds or develops through time."@en ;
  rdfs:subClassOf obo:BFO_0000001 .

obo:SEPIO_0000180 a rdfs:Class ;
  rdfs:label "obsolete_evidence statement"@en ;
  rdfs:comment "A statement (ie an assertion or finding) that is used as evidence to evaluate the validity of a target assertion or proposition." ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_0000001 a rdfs:Class ;
  rdfs:label "assertion"@en ;
  rdfs:comment "A statement made by a particular agent on a particular occasion that a particular proposition is true, based on the evaluation of one or more lines of evidence." ;
  rdfs:subClassOf obo:SEPIO_0000174 .

obo:SEPIO_0000028 a rdf:Property ;
  rdfs:label "assertion_has_predicate"@en ;
  rdfs:comment """Propositional statements can be represented in RDF  as directional subject-predicate-object (S-P-O) triples. RDF reification vocabularies such as OBAN create named individuals in a graph that represent such S-P-O propositional statements. In OBAN, these are called 'associations', and the semantics of these associations can be represented using properties that link it to the subject, predicate, and object of the triple it represents.

As a proposition-level entity, a particular association can be expressed in more than one assertion made by different agents, or at different times. The meaning of an assertion can be captured through its link to an association whose meaning is formally specified as described above (e.g. :assertion1 is_asserted_in :association1, :association1 has_predicate :thing1). 

The assertion_has_predicate property allows more direct specification of assertion meaning, bypassing an association and pointing directly to the predicate of the reified triple.  In this sense, it is a shortcut relation over two more fundamental properties (is_asserted_in  o  association_has_predicate).

This property is useful when a particular dataset wants to describe statements at the level of assertions rather than propositions, and formally describe assertion semantics without needed to represent an proposition-level association.""" ;
  rdfs:domain obo:SEPIO_0000001 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:SEPIO_0000027 a rdf:Property ;
  rdfs:label "assertion_has_object"@en ;
  rdfs:comment """Propositional statements can be represented in RDF  as directional subject-predicate-object (S-P-O) triples. RDF reification vocabularies such as OBAN create named individuals in a graph that represent such S-P-O propositional statements. In OBAN, these are called 'associations', and the semantics of these associations can be represented using properties that link it to the subject, predicate, and object of the triple it represents.

As a proposition-level entity, a particular association can be expressed in more than one assertion made by different agents, or at different times. The meaning of an assertion can be captured through its link to an association whose meaning is formally specified as described above (e.g. :assertion1 is_asserted_in :association1, :association1 has_object :thing1). 

The assertion_has_object property allows more direct specification of assertion meaning, bypassing an association and pointing directly to the object of the reified triple.  In this sense, it is a shortcut relation over two more fundamental properties (is_asserted_in  o  association_has_object).

This property is useful when a particular dataset wants to describe statements at the level of assertions rather than propositions, and formally describe assertion semantics without needed to represent an proposition-level association.""" ;
  rdfs:domain obo:SEPIO_0000001 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:SEPIO_0000197 a rdf:Property ;
  rdfs:label "asserted_conclusion"@en ;
  rdfs:comment "A relationship that holds between an assertion and a term that summarizes its asserted conclusion." ;
  rdfs:domain obo:SEPIO_0000001 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000030 a rdf:Property ;
  rdfs:label "asserts_proposition" ;
  rdfs:comment "A relation holding between an assertion and the proposition that it puts forth as true." ;
  rdfs:domain obo:SEPIO_0000001 ;
  rdfs:range obo:SEPIO_0000000 .

obo:SEPIO_0000165 a rdf:Property ;
  rdfs:label "date_validated"@en ;
  rdfs:comment "The date that a particular resource or digital artifact was formally validated as meeting some standard for  quality, completeness, relevance, etc.." ;
  rdfs:domain obo:SEPIO_0000001 ;
  rdfs:range xsd:dateTime ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/date> .

obo:SEPIO_0000026 a rdf:Property ;
  rdfs:label "assertion_has_subject"@en ;
  rdfs:comment """Propositional statements can be represented in RDF  as directional subject-predicate-object (S-P-O) triples. RDF reification vocabularies such as OBAN create named individuals in a graph that represent such S-P-O propositional statements. In OBAN, these are called 'associations', and the semantics of these associations can be represented using properties that link it to the subject, predicate, and object of the triple it represents.

As a proposition-level entity, a particular association can be expressed in more than one assertion made by different agents, or at different times. The meaning of an assertion can be captured through its link to an association whose meaning is formally specified as described above (e.g. :assertion1 is_asserted_in :association1, :association1 has_subject :thing1). 

The assertion_has_subject property allows more direct specification of assertion meaning, bypassing an association and pointing directly to the subject of the reified triple.  In this sense, it is a shortcut relation over two more fundamental properties (is_asserted_in  o  association_has_subject).

This property is useful when a particular dataset wants to describe statements at the level of assertions rather than propositions, and formally describe assertion semantics without needed to represent an proposition-level association.""" ;
  rdfs:domain obo:SEPIO_0000001 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:SEPIO_0000069 a rdfs:Class ;
  rdfs:label "interventional clinical study"@en ;
  rdfs:subClassOf obo:SEPIO_0000067 .

obo:BFO_0000031 a rdfs:Class ;
  rdfs:label "generically dependent continuant"@en ;
  rdfs:comment "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:SEPIO_0000073 a rdfs:Class ;
  rdfs:label "in vitro study"@en ;
  rdfs:subClassOf obo:SEPIO_0000072 .

obo:SEPIO_0000058 a rdfs:Class ;
  rdfs:label "provenance"@en ;
  rdfs:comment "The process history leading to the creation and current condition of an artifact." ;
  rdfs:subClassOf obo:BFO_0000182 .

<https://w3id.org/linkml/Any> a rdfs:Class ;
  rdfs:comment "An unconstrained type or object" .

obo:IAO_0000005 a rdfs:Class ;
  rdfs:label "objective specification" ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:SEPIO_0000131 a rdfs:Class ;
  rdfs:label "curation"@en ;
  rdfs:comment "A planned process in which existing data is collected, organized, and improved in preparation for subsequent use." ;
  rdfs:subClassOf obo:SEPIO_0000004 .

obo:SEPIO_0000185 a rdfs:Class ;
  rdfs:label "obsolete_data table"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:SEPIO_0000174 a rdfs:Class ;
  rdfs:label "statement"@en ;
  rdfs:comment "An information content entity expressing a declarative sentence that is either true or false." ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:IAO_0000027 a rdfs:Class ;
  rdfs:label "data item"@en ;
  rdfs:comment "a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:IAO_0000310 a rdfs:Class ;
  rdfs:label "document"@en ;
  rdfs:comment "A collection of information content entities intended to be understood together as a whole"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0000175 a rdfs:Class ;
  rdfs:label "p-value"@en ;
  rdfs:comment "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone."@en ;
  rdfs:subClassOf obo:STATO_0000039 .

obo:SEPIO_0000076 a rdfs:Class ;
  rdfs:label "cell-based in vivo study"@en ;
  rdfs:subClassOf obo:SEPIO_0000074 .

obo:COB_0000016 a rdf:Property ;
  rdfs:label "executed by"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:ERO_0000480 a rdf:Property ;
  rdfs:label "has_url"@en ;
  rdfs:comment "Web address of the resource" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0000111 a rdf:Property ;
  rdfs:label "editor preferred term"@en ;
  rdfs:comment "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000112 a rdf:Property ;
  rdfs:label "example of usage"@en ;
  rdfs:comment "A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold."@en ;
  rdfs:range xsd:string .

obo:IAO_0000114 a rdf:Property ;
  rdfs:label "has curation status"@en ;
  rdfs:range xsd:string .

obo:IAO_0000115 a rdf:Property ;
  rdfs:label "definition" ;
  rdfs:comment "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en ;
  rdfs:range xsd:string .

obo:IAO_0000116 a rdf:Property ;
  rdfs:label "editor note"@en ;
  rdfs:comment "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
  rdfs:range xsd:string .

obo:IAO_0000117 a rdf:Property ;
  rdfs:label "term editor"@en ;
  rdfs:comment "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
  rdfs:range xsd:string .

obo:IAO_0000118 a rdf:Property ;
  rdfs:label "alternative label"@en ;
  rdfs:comment "A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like."@en ;
  rdfs:range xsd:string .

obo:IAO_0000119 a rdf:Property ;
  rdfs:label "definition source"@en ;
  rdfs:comment "Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
  rdfs:range xsd:string .

obo:IAO_0000231 a rdf:Property ;
  rdfs:label "has obsolescence reason"@en ;
  rdfs:comment "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en ;
  rdfs:range xsd:string .

obo:IAO_0000232 a rdf:Property ;
  rdfs:label "curator note"@en ;
  rdfs:comment "An administrative note of use for a curator but of no use for a user"@en ;
  rdfs:range xsd:string .

obo:IAO_0000412 a rdf:Property ;
  rdfs:label "imported from"@en ;
  rdfs:comment "For external terms/classes, the ontology from which the term was imported"@en ;
  rdfs:range xsd:string .

obo:IAO_0100001 a rdf:Property ;
  rdfs:label "term replaced by"@en ;
  rdfs:comment "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en ;
  rdfs:range xsd:string .

obo:OBI_0000295 a rdf:Property ;
  rdfs:label "is specified input of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:OBI_0000312 a rdf:Property ;
  rdfs:label "is specified output of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:OBI_0000999 a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000052 a rdf:Property ;
  rdfs:label "characteristic of"@en ;
  rdfs:comment "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002314 .

obo:RO_0000053 a rdf:Property ;
  rdfs:label "has characteristic" ;
  rdfs:comment "Inverse of characteristic_of"@en ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/pull/284> ;
  rdfs:range obo:BFO_0000020 .

obo:RO_0000058 a rdf:Property ;
  rdfs:label "is concretized as"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000080 a rdf:Property ;
  rdfs:label "quality of"@en ;
  rdfs:comment "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000081 a rdf:Property ;
  rdfs:label "role of"@en ;
  rdfs:comment "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000086 a rdf:Property ;
  rdfs:label "has quality"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range obo:BFO_0000019 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0000092 a rdf:Property ;
  rdfs:label "disposition of"@en ;
  rdfs:comment "inverse of has disposition" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0002013 a rdf:Property ;
  rdfs:label "has regulatory component activity" ;
  rdfs:comment "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 , obo:RO_0002017 .

obo:RO_0002014 a rdf:Property ;
  rdfs:label "has negative regulatory component activity" ;
  rdfs:comment "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002335 , obo:RO_0002013 .

obo:RO_0002015 a rdf:Property ;
  rdfs:label "has positive regulatory component activity" ;
  rdfs:comment "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002336 , obo:RO_0002013 .

obo:RO_0002017 a rdf:Property ;
  rdfs:label "has component activity" ;
  rdfs:comment "A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002018 .

obo:RO_0002022 a rdf:Property ;
  rdfs:label "directly regulated by" ;
  rdfs:comment "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002023 a rdf:Property ;
  rdfs:label "directly negatively regulated by" ;
  rdfs:comment "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002022 .

obo:RO_0002024 a rdf:Property ;
  rdfs:label "directly positively regulated by" ;
  rdfs:comment "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002022 .

obo:RO_0002025 a rdf:Property ;
  rdfs:label "has effector activity" ;
  rdfs:comment "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002017 .

obo:RO_0002086 a rdf:Property ;
  rdfs:label "ends after"@en ;
  rdfs:comment "X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002087 a rdf:Property ;
  rdfs:label "immediately preceded by"@en ;
  rdfs:comment "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000062 .

obo:RO_0002090 a rdf:Property ;
  rdfs:label "immediately precedes"@en ;
  rdfs:comment "X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000063 .

obo:RO_0002131 a rdf:Property ;
  rdfs:label "overlaps"@en ;
  rdfs:comment "x overlaps y if and only if there exists some z such that x has part z and z part of y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002180 a rdf:Property ;
  rdfs:label "has component"@en ;
  rdfs:comment "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
  rdfs:seeAlso <http://ontologydesignpatterns.org/wiki/Submissions:Componency> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002203 a rdf:Property ;
  rdfs:label "develops into"@en ;
  rdfs:comment "inverse of develops from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002387 , obo:RO_0002388 , obo:RO_0002286 .

obo:RO_0002212 a rdf:Property ;
  rdfs:label "negatively regulates"@en ;
  rdfs:comment "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002305 , obo:RO_0002211 .

obo:RO_0002213 a rdf:Property ;
  rdfs:label "positively regulates"@en ;
  rdfs:comment "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002304 , obo:RO_0002211 .

obo:RO_0002216 a rdf:Property ;
  rdfs:label "capable of part of"@en ;
  rdfs:comment "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/reflexivity/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002500 , obo:RO_0002328 .

obo:RO_0002255 a rdf:Property ;
  rdfs:label "developmentally contributes to"@en ;
  rdfs:comment "inverse of has developmental contribution from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002385 , obo:RO_0002286 .

obo:RO_0002259 a rdf:Property ;
  rdfs:range xsd:string .

obo:RO_0002263 a rdf:Property ;
  rdfs:label "acts upstream of" ;
  rdfs:comment "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Acts_upstream_of> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0002264 a rdf:Property ;
  rdfs:label "acts upstream of or within" ;
  rdfs:comment "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002500 .

obo:RO_0002286 a rdf:Property ;
  rdfs:label "developmentally succeeded by"@en ;
  rdfs:comment "Inverse of developmentally preceded by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002384 .

obo:RO_0002304 a rdf:Property ;
  rdfs:label "causally upstream of, positive effect" ;
  rdfs:comment "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004047 , obo:RO_0002411 .

obo:RO_0002305 a rdf:Property ;
  rdfs:label "causally upstream of, negative effect" ;
  rdfs:comment "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004046 , obo:RO_0002411 .

obo:RO_0002314 a rdf:Property ;
  rdfs:label "characteristic of part of"@en ;
  rdfs:comment "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/reflexivity/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002502 .

obo:RO_0002323 a rdf:Property ;
  rdfs:label "mereotopologically related to"@en ;
  rdfs:comment "A mereological relationship or a topological relationship" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002324 a rdf:Property ;
  rdfs:label "developmentally related to"@en ;
  rdfs:comment "A relationship that holds between entities participating in some developmental process (GO:0032502)" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002327 a rdf:Property ;
  rdfs:label "enables"@en ;
  rdfs:comment "c enables p iff c is capable of p and c acts to execute p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002215 .

obo:RO_0002328 a rdf:Property ;
  rdfs:label "functionally related to"@en ;
  rdfs:comment "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002329 a rdf:Property ;
  rdfs:label "part of structure that is capable of"@en ;
  rdfs:comment "this relation holds between c and p when c is part of some c', and c' is capable of p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 .

obo:RO_0002331 a rdf:Property ;
  rdfs:label "involved in"@en ;
  rdfs:comment "c involved_in p if and only if c enables some process p', and p' is part of p" ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Involved_in> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002431 , obo:RO_0000056 .

obo:RO_0002333 a rdf:Property ;
  rdfs:label "enabled by"@en ;
  rdfs:comment "inverse of enables" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000057 .

obo:RO_0002335 a rdf:Property ;
  rdfs:label "negatively regulated by"@en ;
  rdfs:comment "inverse of negatively regulates" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002336 a rdf:Property ;
  rdfs:label "positively regulated by"@en ;
  rdfs:comment "inverse of positively regulates" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002350 a rdf:Property ;
  rdfs:label "member of" ;
  rdfs:comment "is member of is a mereological relation between a item and a collection." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0002351 a rdf:Property ;
  rdfs:label "has member" ;
  rdfs:comment "Has member is a mereological relation between a collection and an item." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002352 a rdf:Property ;
  rdfs:label "input of"@en ;
  rdfs:comment "inverse of has input" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000056 .

obo:RO_0002385 a rdf:Property ;
  rdfs:label "has potential to developmentally contribute to"@en ;
  rdfs:comment "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002384 .

obo:RO_0002387 a rdf:Property ;
  rdfs:label "has potential to develop into"@en ;
  rdfs:comment "x has the potential to develop into y iff x develops into y or if x is capable of developing into y"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002384 .

obo:RO_0002388 a rdf:Property ;
  rdfs:label "has potential to directly develop into"@en ;
  rdfs:comment "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002387 .

obo:RO_0002404 a rdf:Property ;
  rdfs:label "causally downstream of"@en ;
  rdfs:comment "inverse of upstream of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002427 , obo:BFO_0000062 .

obo:RO_0002405 a rdf:Property ;
  rdfs:label "immediately causally downstream of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002404 , obo:RO_0002087 .

obo:RO_0002407 a rdf:Property ;
  rdfs:label "indirectly positively regulates"@en ;
  rdfs:comment "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012012 , obo:RO_0002213 .

obo:RO_0002409 a rdf:Property ;
  rdfs:label "indirectly negatively regulates"@en ;
  rdfs:comment "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012012 , obo:RO_0002212 .

obo:RO_0002410 a rdf:Property ;
  rdfs:label "causally related to"@en ;
  rdfs:comment "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002411 a rdf:Property ;
  rdfs:label "causally upstream of"@en ;
  rdfs:comment "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002418 , obo:BFO_0000063 .

obo:RO_0002412 a rdf:Property ;
  rdfs:label "immediately causally upstream of"@en ;
  rdfs:comment "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002411 , obo:RO_0002090 .

obo:RO_0002418 a rdf:Property ;
  rdfs:label "causally upstream of or within" ;
  rdfs:comment "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002501 .

obo:RO_0002427 a rdf:Property ;
  rdfs:label "causally downstream of or within" ;
  rdfs:comment "inverse of causally upstream of or within" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002501 .

obo:RO_0002428 a rdf:Property ;
  rdfs:label "involved in regulation of" ;
  rdfs:comment "c involved in regulation of p if c is involved in some p' and p' regulates some p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002431 , obo:RO_0002263 .

obo:RO_0002429 a rdf:Property ;
  rdfs:label "involved in positive regulation of" ;
  rdfs:comment "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002428 .

obo:RO_0002430 a rdf:Property ;
  rdfs:label "involved in negative regulation of" ;
  rdfs:comment "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002428 .

obo:RO_0002431 a rdf:Property ;
  rdfs:label "involved in or involved in regulation of" ;
  rdfs:comment "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0002500 , obo:RO_0002264 .

obo:RO_0002436 a rdf:Property ;
  rdfs:label "molecularly interacts with" ;
  rdfs:comment "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." ;
  rdfs:seeAlso obo:ECO_0000353 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002434 .

obo:RO_0002447 a rdf:Property ;
  rdfs:label "phosphorylates" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002436 .

obo:RO_0002464 a rdf:Property ;
  rdfs:label "helper property (not for use in curation)" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002481 a rdf:Property ;
  rdfs:label "is kinase activity" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002564 .

obo:RO_0002500 a rdf:Property ;
  rdfs:label "causal agent in process" ;
  rdfs:comment "A relationship between a material entity and a process where the material entity has some causal role that influences the process" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002595 .

obo:RO_0002502 a rdf:Property ;
  rdfs:label "depends on" ;
  rdfs:seeAlso obo:BFO_0000169 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002559 a rdf:Property ;
  rdfs:label "causally influenced by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002506 .

obo:RO_0002563 a rdf:Property ;
  rdfs:label "interaction relation helper property" ;
  rdfs:seeAlso <http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29> , <http://purl.obolibrary.org/obo/ro/docs/interaction-relations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002464 .

obo:RO_0002564 a rdf:Property ;
  rdfs:label "molecular interaction relation helper property" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002563 .

obo:RO_0002578 a rdf:Property ;
  rdfs:label "directly regulates" ;
  rdfs:comment "p directly regulates q iff p is immediately causally upstream of q and p regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002412 , obo:RO_0002211 .

obo:RO_0002581 a rdf:Property ;
  rdfs:label "is a defining property chain axiom" ;
  rdfs:comment "If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL" ;
  rdfs:range xsd:string .

obo:RO_0002582 a rdf:Property ;
  rdfs:label "is a defining property chain axiom where second argument is reflexive" ;
  rdfs:comment "If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R." ;
  rdfs:range xsd:string .

obo:RO_0002584 a rdf:Property ;
  rdfs:label "has part structure that is capable of" ;
  rdfs:comment "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002595 , obo:RO_0002328 .

obo:RO_0002596 a rdf:Property ;
  rdfs:label "capable of regulating" ;
  rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a regulates p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002500 .

obo:RO_0002597 a rdf:Property ;
  rdfs:label "capable of negatively regulating" ;
  rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002596 .

obo:RO_0002598 a rdf:Property ;
  rdfs:label "capable of positively regulating" ;
  rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002596 .

obo:RO_0002608 a rdf:Property ;
  rdfs:label "process has causal agent" ;
  rdfs:comment "Inverse of 'causal agent in process'" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002616 a rdf:Property ;
  rdfs:label "related via evidence or inference to" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002629 a rdf:Property ;
  rdfs:label "directly positively regulates" ;
  rdfs:comment "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002578 , obo:RO_0002213 .

obo:RO_0002630 a rdf:Property ;
  rdfs:label "directly negatively regulates" ;
  rdfs:comment "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002578 , obo:RO_0002212 .

obo:RO_0004031 a rdf:Property ;
  rdfs:label "enables subfunction" ;
  rdfs:comment "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 .

obo:RO_0004032 a rdf:Property ;
  rdfs:label "acts upstream of or within, positive effect" ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0004033 a rdf:Property ;
  rdfs:label "acts upstream of or within, negative effect" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0004034 a rdf:Property ;
  rdfs:label "acts upstream of, positive effect" ;
  rdfs:comment "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004032 , obo:RO_0002263 .

obo:RO_0004035 a rdf:Property ;
  rdfs:label "acts upstream of, negative effect" ;
  rdfs:comment "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004033 , obo:RO_0002263 .

obo:RO_0004046 a rdf:Property ;
  rdfs:label "causally upstream of or within, negative effect" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0004047 a rdf:Property ;
  rdfs:label "causally upstream of or within, positive effect" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0012011 a rdf:Property ;
  rdfs:label "indirectly causally upstream of"@en ;
  rdfs:comment "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002411 .

obo:RO_0012012 a rdf:Property ;
  rdfs:label "indirectly regulates"@en ;
  rdfs:comment "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012011 , obo:RO_0002211 .

obo:RO_0017001 a rdf:Property ;
  rdfs:label "device utilizes material"@en ;
  rdfs:comment "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0019001 a rdf:Property ;
  rdfs:label "positively regulates characteristic" ;
  rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0019000 .

obo:RO_0019002 a rdf:Property ;
  rdfs:label "negatively regulates characteristic" ;
  rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0019000 .

obo:SEPIO_0000007 a rdf:Property ;
  rdfs:label "has_supporting_evidence_line"@en ;
  rdfs:comment "A relation between a proposition and information that supports its validity, based on the evaluation of some agent." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000006 .

obo:SEPIO_0000008 a rdf:Property ;
  rdfs:label "has_disputing_evidence_line"@en ;
  rdfs:comment "A relation between a proposition and information that contradicts its validity, based on the evaluation and conclusion of some agent." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000006 .

obo:SEPIO_0000009 a rdf:Property ;
  rdfs:label "has_inconclusive_evidence_line"@en ;
  rdfs:comment "A relation between a proposition and information that was used to evaluate a particular proposition, but failed to provide conclusive support for or against its validity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000006 .

obo:SEPIO_0000021 a rdf:Property ;
  rdfs:label "obsolete_date_created"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000041 a rdf:Property ;
  rdfs:label "was_specified_by"@en ;
  rdfs:comment "A relation holding between a planned process, or the artifact it generates, and a plan specification that specifies all or part of the process (e.g. a protocol, guideline, rule set)" ;
  rdfs:range obo:IAO_0000104 .

obo:SEPIO_0000052 a rdf:Property ;
  rdfs:label "consider"@en ;
  rdfs:range xsd:string .

obo:SEPIO_0000061 a rdf:Property ;
  rdfs:label "SEPIO_editor_note"@en ;
  rdfs:comment "Used to capture development notes and design decisions or questions. All annotations using this property should be removed before publishing / releasing the ontology to the public (but ideally retained in some place as valuable documentation)." ;
  rdfs:range xsd:string .

obo:SEPIO_0000098 a rdf:Property ;
  rdfs:label "is_equilavent_to"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000116 .

obo:SEPIO_0000099 a rdf:Property ;
  rdfs:label "is_consistent_with" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000116 .

obo:SEPIO_0000101 a rdf:Property ;
  rdfs:label "contradicts" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000115 .

obo:SEPIO_0000105 a rdf:Property ;
  rdfs:label "date_created_before"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000434 .

obo:SEPIO_0000113 a rdf:Property ;
  rdfs:label "has_compatability"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000406 .

obo:SEPIO_0000114 a rdf:Property ;
  rdfs:label "measures_parameter" ;
  rdfs:comment "A relation between a planned process and a parameter that it measures as part of an assay or observation." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000406 .

obo:SEPIO_0000115 a rdf:Property ;
  rdfs:label "conflicts_with"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000113 .

obo:SEPIO_0000116 a rdf:Property ;
  rdfs:label "aligns_with"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000113 .

obo:SEPIO_0000123 a rdf:Property ;
  rdfs:label "has_textual_part"@en ;
  rdfs:comment "Relation between a report and a string of text that it contains" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000126 a rdf:Property ;
  rdfs:label "is_inconsistent_with"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000113 .

obo:SEPIO_0000135 a rdf:Property ;
  rdfs:label "date_authored"@en ;
  rdfs:comment "A relation holding between an information content entity and the date on which the information it expresses was initially generated." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/date> .

obo:SEPIO_0000140 a rdf:Property ;
  rdfs:label "evaluated_by" ;
  rdfs:comment "A relation holding between a generated artifact and an agent who evaluated its quality, completeness, or utility." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000150 .

obo:SEPIO_0000150 a rdf:Property ;
  rdfs:label "has_contributor"@en ;
  rdfs:comment "A relation between an information content entity and an agent who made a contribution to its information content, or to its subsequent modification or assessment." ;
  rdfs:range <http://www.w3.org/ns/prov#Agent> .

obo:SEPIO_0000151 a rdf:Property ;
  rdfs:label "validated_by" ;
  rdfs:comment "A relation holding between a statement and an agent that validates its truth or accuracy - typically by reviewing the provenance and data on which it is based." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000150 .

obo:SEPIO_0000152 a rdf:Property ;
  rdfs:label "obsolete_evidence_assessed_by"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:SEPIO_0000159 a rdf:Property ;
  rdfs:label "qualified_contribution"@en ;
  rdfs:comment "A relation holding between an artifact and a contribution made by a particular agent to its creation, modification, assessment, or destruction." ;
  rdfs:range obo:SEPIO_0000158 .

obo:SEPIO_0000161 a rdf:Property ;
  rdfs:label "end_date"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000160 .

obo:SEPIO_0000162 a rdf:Property ;
  rdfs:label "obsolete_date_curated"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000164 a rdf:Property ;
  rdfs:label "date_updated"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/date> .

obo:SEPIO_0000178 a rdf:Property ;
  rdfs:label "is_described_by"@en ;
  rdfs:comment "A relation between one entity and an informtion content entity that provides a description of it." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000184 a rdf:Property ;
  rdfs:label "usage note"@en ;
  rdfs:range xsd:string .

obo:SEPIO_0000188 a rdf:Property ;
  rdfs:label "contributes_to"@en ;
  rdfs:comment "A relation between an agent and an entity toward which the agent made a contribution." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000231 a rdf:Property ;
  rdfs:label "statement quantifier"@en ;
  rdfs:comment "A relation used to link a statement to some quantitative measure about the statement itself (e.g. a confidence score)" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000232 a rdf:Property ;
  rdfs:label "obsolete_has_quantifier"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:SEPIO_0000337 a rdf:Property ;
  rdfs:label "in_value_set"@en ;
  rdfs:range xsd:string .

obo:SEPIO_0000346 a rdf:Property ;
  rdfs:label "statement qualifier"@en ;
  rdfs:comment "A relation used to qualify the meaning of a statement." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000384 a rdf:Property ;
  rdfs:label "date_created_after"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000434 .

obo:SEPIO_0000386 a rdf:Property ;
  rdfs:label "sepio_preferred_label"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000118 .

obo:SEPIO_0000388 a rdf:Property ;
  rdfs:label "has_subject"@en ;
  rdfs:comment "A relation that holds between a statement or proposition which can be captured in part or in whole as a directional relationship between two entities, and the entity that representing the subject of this relationship." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:SEPIO_0000389 a rdf:Property ;
  rdfs:label "has_predicate"@en ;
  rdfs:comment "A relation that holds between a statement or proposition which can be captured in part or in whole as a directional relationship between two entities, and the property serving as the predicate in this relationship." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:SEPIO_0000390 a rdf:Property ;
  rdfs:label "has_object"@en ;
  rdfs:comment "A relation that holds between a statement or proposition which can be captured in part or in whole as a directional relationship between two entities, and the entity that representing the object or value of this relationship." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:SEPIO_0000398 a rdf:Property ;
  rdfs:label "has_evidence_of_type"@en ;
  rdfs:comment "A shortcut relation that links an assertion directly to a term representing the type of evidence that supports it." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000399 a rdf:Property ;
  rdfs:label "is_shortcut"@en ;
  rdfs:comment """Annotation indicating whether a property represents a \"shortcut\" relation that can be used to directly link two objects that are indirectly linked through a longer path of two or more edges.  Shortcut relations can be logically expanded to be expressed in terms of this longer path, e.g. 

has_evidence_from_source = has_evidence_line o has_evidence_item o source.""" ;
  rdfs:range xsd:boolean .

obo:SEPIO_0000406 a rdf:Property ;
  rdfs:label "ExploratoryObjectProperty"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000419 a rdf:Property ;
  rdfs:label "probabilistic quantifier"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000168 .

obo:SEPIO_0000427 a rdf:Property ;
  rdfs:label "is_evidence_line_for"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000433 a rdf:Property ;
  rdfs:label "activity_location" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000434 a rdf:Property ;
  rdfs:label "ExploratoryDataProperty" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000435 a rdf:Property ;
  rdfs:label "ObsoleteDataProperty" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000436 a rdf:Property ;
  rdfs:label "date_created" ;
  rdfs:comment """Date that a particular representation/manifestation of an information content entity was created - e.g. as a web resource or digital artifact.  

To describe the date that the information content carried by a digital artifact or resource as generated, use the 'date_authored' property.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/date> .

obo:SEPIO_0000437 a rdf:Property ;
  rdfs:label "provided_by" ;
  rdfs:comment "A relationship between an information resource found in some information system, and the agent (person, organization, computational agent) who is responsible for sharing/providing it to that information system." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:SEPIO_0000438 a rdf:Property ;
  rdfs:label "has_supporting_evidence_from_source"@en ;
  rdfs:comment "A relation used to link an assertion or proposition to a source where supporting evidence for it was found (i.e. a document, document part, database, etc)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000145 .

obo:SEPIO_0000439 a rdf:Property ;
  rdfs:label "has_disputing_evidence_from_source"@en ;
  rdfs:comment "A relation used to link an assertion or proposition to a source where disputing evidence for it was found (i.e. a document, document part, database, etc)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000145 .

obo:SEPIO_0000440 a rdf:Property ;
  rdfs:label "has_supporting_evidence"@en ;
  rdfs:comment "A relation that directly connects an assertion and a piece of information that contributes to an evidence line interpreted to support the truth of the assertion." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000189 .

obo:SEPIO_0000441 a rdf:Property ;
  rdfs:label "has_disputing_evidence"@en ;
  rdfs:comment "A relation that directly connects an assertion and a piece of information that contributes to an evidence line interpreted to dispute the truth of the assertion." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:SEPIO_0000189 .

obo:SEPIO_0000442 a rdf:Property ;
  rdfs:label "reference"@en ;
  rdfs:comment "Links an entity to a document that describes it." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:STATO_0000102 a rdf:Property ;
  rdfs:label "executes" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:STATO_0000129 a rdf:Property ;
  rdfs:label "has_value"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/ro/subsets#ro-eco> a rdf:Property ;
  rdfs:label "eco subset" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/subsets/> ;
  rdfs:range xsd:string .

obo:valid_for_go_annotation_extension a rdf:Property ;
  rdfs:range xsd:string .

obo:valid_for_go_gp2term a rdf:Property ;
  rdfs:range xsd:string .

obo:valid_for_go_ontology a rdf:Property ;
  rdfs:range xsd:string .

obo:valid_for_gocam a rdf:Property ;
  rdfs:range xsd:string .

<http://purl.org/dc/elements/1.1/description> a rdf:Property ;
  rdfs:label "description" ;
  rdfs:comment "An account of a resource." ;
  rdfs:range xsd:string .

<http://purl.org/dc/terms/identifier> a rdf:Property ;
  rdfs:label "identifier"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.org/dc/terms/source> a rdf:Property ;
  rdfs:label "source"@en ;
  rdfs:comment "A related resource from which the described resource is derived." ;
  rdfs:range obo:IAO_0000030 .

<http://purl.org/dc/terms/title> a rdf:Property ;
  rdfs:label "title" ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.org/ontology/bibo/doi> a rdf:Property ;
  rdfs:label "digital object identifier (doi)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/identifier> .

<http://purl.org/pav/authoredBy> a rdf:Property ;
  rdfs:label "Authored by" ;
  rdfs:comment """An agent that originated or gave existence to the work that is expressed by the digital resource.

The author of the content of a resource may be different from the creator of the resource representation (although they are often the same). See pav:createdBy for a discussion.

pav:authoredBy is more specific than its superproperty dct:creator - which might or might not be interpreted to also cover the creation of the representation of the artifact.

The author is usually not a software agent (which would be indicated with pav:createdWith, pav:createdBy or pav:importedBy), unless the software actually authored the content itself; for instance an artificial intelligence algorithm which authored a piece of music or a machine learning algorithm that authored a classification of a tumor sample.

The date of authoring can be expressed using pav:authoredOn - note however in the case of multiple authors that there is no relationship in PAV identifying which agent contributed when or what. If capturing such lineage is desired, it should be additionally expressed using PROV relationships like prov:qualifiedAttribution or prov:wasGeneratedBy.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

<http://purl.org/pav/createdBy> a rdf:Property ;
  rdfs:label "Created by"@en ;
  rdfs:comment """An agent primary responsible for making the digital artifact or resource representation. 
This property is distinct from forming the content, which is indicated with pav:contributedBy or its subproperties; pav:authoredBy, which identifies who authored the knowledge expressed by this resource; and pav:curatedBy, which identifies who curated the knowledge into its current form. 
pav:createdBy is more specific than its superproperty dct:creator - which might or might not be interpreted to cover this creator. 
For instance, the author wrote 'this species has bigger wings than normal' in his log book. The curator, going through the log book and identifying important knowledge, formalizes this as 'locus perculus has wingspan > 0.5m'. The creator enters this knowledge as a digital resource in the knowledge system, thus creating the digital artifact (say as JSON, RDF, XML or HTML). 
A different example is a news article. pav:authoredBy indicates the journalist who wrote the article. pav:contributedBy can indicate the artist who added an illustration. pav:curatedBy can indicate the editor who made the article conform to the news paper's style. pav:createdBy can indicate who put the article on the web site.
The software tool used by the creator to make the digital resource (say Protege, Wordpress or OpenOffice) can be indicated with pav:createdWith.

The date the digital resource was created can be indicated with pav:createdOn.

The location the agent was at when creating the digital resource can be made using pav:createdAt.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

<http://purl.org/pav/curatedBy> a rdf:Property ;
  rdfs:label "Curated by"@en ;
  rdfs:comment """Specifies an agent specialist responsible for shaping the expression in an appropriate format. Often the primary agent responsible for ensuring the quality of the representation.

The curator may be different from the author (pav:authoredBy) and creator of the digital resource (pav:createdBy).

The curator may in some cases be a software agent, for instance text mining software which adds hyperlinks for recognized genome names.

The date of curating can be expressed using pav:curatedOn - note however in the case of multiple curators that there is no relationship in PAV identifying which agent contributed when or what. If capturing such lineage is desired, it should be additionally expressed using PROV relationships like prov:qualifiedAttribution or prov:wasGeneratedBy""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

<http://purl.org/pav/derivedFrom> a rdf:Property ;
  rdfs:label "Derived from" ;
  rdfs:comment """Derived from a different resource.

Derivation conserns itself with derived knowledge. If this resource has the same content as the other resource, but has simply been transcribed to fit a different model (like XML -> RDF or SQL -> CVS), use pav:importedFrom. If a resource was simply retrieved, use pav:retrievedFrom. If the content has however been further refined or modified, pav:derivedFrom should be used.

Details about who performed the derivation (e.g. who did the refining or modifications) may be indicated with pav:contributedBy and its subproperties.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/source> .

<http://purl.org/pav/importedFrom> a rdf:Property ;
  rdfs:label "Imported from"@en ;
  rdfs:comment """The original source of imported information.

Import means that the content has been preserved, but transcribed somehow, for instance to fit a different representation model by converting formats. Examples of import are when the original was JSON and the current resource is RDF, or where the original was an document scan, and this resource is the plain text found through OCR.

The imported resource does not have to be complete, but should be consistent with the knowledge conveyed by the original resource.

If additional knowledge has been contributed, pav:derivedFrom would be more appropriate.

If the resource has been copied verbatim from the original representation (e.g. downloaded), use pav:retrievedFrom.

To indicate which agent(s) performed the import, use pav:importedBy. Use pav:importedOn to indicate when it happened.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/source> .

<http://purl.org/pav/retrievedFrom> a rdf:Property ;
  rdfs:label "Retrieved from" ;
  rdfs:comment """The URI where a resource has been retrieved from.

The retrieving agent is usually a software entity, which has done the retrieval from the original source without performing any transcription.

Retrieval indicates that this resource has the same representation as the original resource. If the resource has been somewhat transformed, use pav:importedFrom instead.

The time of the retrieval should be indicated using pav:retrievedOn. The agent may be indicated with pav:retrievedBy.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://purl.org/dc/terms/source> .

<http://purl.org/pav/sourceAccessedAt> a rdf:Property ;
  rdfs:label "Source accessed at" ;
  rdfs:comment """The resource is related to a given source which was accessed or consulted (but not retrieved, imported or derived from). This access can be detailed with pav:sourceAccessedBy and pav:sourceAccessedOn.

For instance, a curator (pav:curatedBy) might have consulted figures in a published paper to confirm that a dataset was correctly pav:importedFrom the paper's supplementary CSV file.

Another example: I can access the page for tomorrow weather in Boston (http://www.weather.com/weather/tomorrow/Boston+MA+02143)  and I can blog ‘tomorrow is going to be nice’. The source does not make any claims about the nice weather, that is my interpretation; therefore the blog post has pav:sourceAccessedAt the weather page.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

<http://purl.org/pav/version> a rdf:Property ;
  rdfs:label "version" ;
  rdfs:comment """The version number of a resource. This is a freetext string, typical values are \"1.5\" or \"21\". The URI identifying the previous version can be provided using prov:previousVersion.

This property is normally used in a functional way, although PAV does not formally restrict this.""" ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://xmlns.com/foaf/0.1/name> a rdf:Property ;
  rdfs:label "name" ;
  rdfs:comment "A name for some thing." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0000078 a rdfs:Class ;
  rdfs:label "curation status specification"@en ;
  rdfs:comment "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
  rdfs:subClassOf obo:IAO_0000102 .

obo:IAO_0000002 a obo:IAO_0000078 ;
  rdfs:label "example to be eventually removed"@en .

obo:IAO_0000120 a obo:IAO_0000078 ;
  rdfs:label "metadata complete"@en ;
  rdfs:comment "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en .

obo:IAO_0000121 a obo:IAO_0000078 ;
  rdfs:label "organizational term"@en ;
  rdfs:comment "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en .

obo:IAO_0000122 a obo:IAO_0000078 ;
  rdfs:label "ready for release"@en ;
  rdfs:comment "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release.  Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""@en .

obo:IAO_0000123 a obo:IAO_0000078 ;
  rdfs:label "metadata incomplete"@en ;
  rdfs:comment "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en .

obo:IAO_0000124 a obo:IAO_0000078 ;
  rdfs:label "uncurated"@en ;
  rdfs:comment "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en .

obo:IAO_0000125 a obo:IAO_0000078 ;
  rdfs:label "pending final vetting"@en ;
  rdfs:comment "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en .

obo:IAO_0000423 a obo:IAO_0000078 ;
  rdfs:label "to be replaced with external ontology term"@en ;
  rdfs:comment "Terms with this status should eventually replaced with a term from another ontology."@en .

obo:IAO_0000428 a obo:IAO_0000078 ;
  rdfs:label "requires discussion"@en ;
  rdfs:comment "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en .

obo:IAO_0000225 a rdfs:Class ;
  rdfs:label "obsolescence reason specification"@en ;
  rdfs:comment "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
  rdfs:subClassOf obo:IAO_0000102 .

obo:IAO_0000103 a obo:IAO_0000225 ;
  rdfs:label "failed exploratory term"@en ;
  rdfs:comment "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"@en .

obo:IAO_0000226 a obo:IAO_0000225 ;
  rdfs:label "placeholder removed"@en .

obo:IAO_0000227 a obo:IAO_0000225 ;
  rdfs:label "terms merged"@en .

obo:IAO_0000228 a obo:IAO_0000225 ;
  rdfs:label "term imported"@en .

obo:IAO_0000229 a obo:IAO_0000225 ;
  rdfs:label "term split"@en .

obo:OMO_0001000 a obo:IAO_0000225 ;
  rdfs:label "out of scope" ;
  rdfs:comment "The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not."@en .

obo:IAO_0000409 a rdfs:Class ;
  rdfs:label "denotator type"@en ;
  rdfs:comment "A denotator type indicates how a term should be interpreted from an ontological perspective."@en ;
  rdfs:subClassOf obo:IAO_0000102 .

obo:IAO_0000410 a obo:IAO_0000409 ;
  rdfs:label "universal"@en .

obo:IAO_0000420 a obo:IAO_0000409 ;
  rdfs:label "defined class"@en ;
  rdfs:comment "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en .

obo:IAO_0000421 a obo:IAO_0000409 ;
  rdfs:label "named class expression"@en ;
  rdfs:comment "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en .

obo:SEPIO_0000402 a rdfs:Class ;
  rdfs:label "evidence direction"@en ;
  rdfs:comment "A data item that indicates an agent's assessment of whether an evidence line  supports or disputes a target proposition (or represents inconclusive evidence that is not sufficient for either)." ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:SEPIO_0000403 a obo:SEPIO_0000402 ;
  rdfs:label "supporting"@en ;
  rdfs:comment "An evidence direction indicating that an evidence line provides an argument that supports the validity of a target assertion." .

obo:SEPIO_0000404 a obo:SEPIO_0000402 ;
  rdfs:label "disputing"@en .

obo:SEPIO_0000405 a obo:SEPIO_0000402 ;
  rdfs:label "inconclusive"@en ;
  rdfs:comment "An evidence direction indicating that an evidence line lacks sufficient credibility, relevance, or completeness to argue for or against the validity of a target assertion." .
