PREFIX obo:
PREFIX rdf:
PREFIX rdfs:
PREFIX xsd:
obo:SCDO_0000851 a rdfs:Class ;
rdfs:label "Pain" ;
rdfs:comment "An unpleasant sensory and emotional experience triggered in the nervous system, associated with actual or potential tissue damage, or described in terms of such damage." ;
rdfs:subClassOf obo:HP_0025142 .
obo:SCDO_0000664 a rdf:Property ;
rdfs:label "treated with" ;
rdfs:comment "A relation between a condition (phenotype or disease) and a type of treatment or a specific treatment, where the condition can be treated with the treatment." ;
rdfs:range .
obo:SCDO_1110663 a rdf:Property ;
rdfs:label "in guideline" ;
rdfs:comment "A relation between an entity (phenotypic, therapeutic or diagnostic concept) and a guideline or directive." ;
rdfs:range .
obo:SCDO_0001158 a rdfs:Class ;
rdfs:label "Indel Mutation" ;
rdfs:comment "A mutation named with the blend of insertion and deletion. It refers to a length difference between two alleles where it is unknowable if the difference was originally caused by a sequence insertion or by a sequence deletion. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a frameshift mutation." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_1000015 a rdf:Property ;
rdfs:label "modifies" ;
rdfs:comment "A relationship between a disease modifier and a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy), where the disease modifier modifies the condition, entity or process in some way." ;
rdfs:range .
obo:HP_0002597 a rdfs:Class ;
rdfs:label "Abnormality of the Vasculature" ;
rdfs:comment "An abnormality of the vasculature." ;
rdfs:subClassOf obo:HP_0001626 .
obo:SCDO_1000131 a rdfs:Class ;
rdfs:label "Yoruba" ;
rdfs:comment "Yoruba is an ethnic group coming from Nigeria and well settled along the eastern boundary of Benin. They are more than 18% of the population. The majority of the Yoruba people in Benin are descendants of the Ife tribe, and the Yoruba people are predominantly of the Muslim religion." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0001297 a rdf:Property ;
rdfs:label "has essential measure" ;
rdfs:comment "A measure that is critical to the collection of the measure at hand or is necessary for the interpretation of results for the measure at hand. Without such information, the data collected would be incomplete or misleading." ;
rdfs:range .
obo:SCDO_0000849 a rdfs:Class ;
rdfs:label "Arterial Oxygen Saturation" ;
rdfs:comment "The amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity, as determined by an arterial blood gas test." ;
rdfs:subClassOf obo:CMO_0000225 , obo:CMO_0001324 .
obo:SCDO_1000523 a rdf:Property ;
rdfs:label "has LLN" ;
rdfs:comment "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000780 a rdf:Property ;
rdfs:label "has ULN female" ;
rdfs:comment "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for females for a particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000777 a rdf:Property ;
rdfs:label "has LLN female" ;
rdfs:comment "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for females for a particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000772 a rdf:Property ;
rdfs:label "has possible finding" ;
rdfs:comment "A relationship between a Diagnostic Measurement and a Phenotype, where the Phenotype is a possible finding of the Diagnostic Measurement, depending on the value recorded for the Diagnostic Measurement." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range obo:HP_0000118 .
obo:SCDO_1000782 a rdf:Property ;
rdfs:label "has reference range standard unit" ;
rdfs:comment "A relationship between a Diagnostic Measurement and the Unit of Measurement used for the values provided by the data properties that specify upper (ULN) or lower (LLN) limit of normal for the Diagnostic Measurement." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range obo:UO_0000000 .
obo:SCDO_1000778 a rdf:Property ;
rdfs:label "has LLN pediatric" ;
rdfs:comment "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for children for a particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000781 a rdf:Property ;
rdfs:label "has ULN pediatric" ;
rdfs:comment "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for children for a particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000779 a rdf:Property ;
rdfs:label "has ULN male" ;
rdfs:comment "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for males for a particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000776 a rdf:Property ;
rdfs:label "has LLN male" ;
rdfs:comment "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for males for a particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000524 a rdf:Property ;
rdfs:label "has ULN" ;
rdfs:comment "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter." ;
rdfs:domain obo:SCDO_0000728 ;
rdfs:range xsd:decimal .
obo:SCDO_1000190 a rdf:Property ;
rdfs:label "obtained via diagnostic tool" ;
rdfs:comment "A relationship between a diagnostic measurement and the diagnostic tool used to produce the measurement." ;
rdfs:range .
obo:SCDO_0000191 a rdfs:Class ;
rdfs:label "Causal Adverse Drug Event" ;
rdfs:comment "A drug adverse event that is caused by a drug administration. Here a causal effect is established between the drug administration and the adverse event." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:HP_0000805 a rdfs:Class ;
rdfs:label "Enuresis" ;
rdfs:comment "Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible." ;
rdfs:subClassOf obo:HP_0000079 , obo:SCDO_0000954 .
obo:SCDO_1000005 a rdf:Property ;
rdfs:label "modified by" ;
rdfs:comment "A relationship between a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy) and a disease modifier, where the condition, entity or process is modified by the disease modifier in some way." ;
rdfs:range .
obo:SCDO_0001378 a rdfs:Class ;
rdfs:label "HBA1" ;
rdfs:comment "This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA2." ;
rdfs:subClassOf obo:SCDO_1000361 .
obo:HP_0100806 a rdfs:Class ;
rdfs:label "Sepsis" ;
rdfs:comment "Severe systemic inflammatory response to infection." ;
rdfs:subClassOf obo:HP_0002715 , obo:IDO_0000586 .
obo:SCDO_0000663 a rdf:Property ;
rdfs:label "diagnosed using tool" ;
rdfs:comment "A relation between a phenotype that is a diagnosis and a diagnostic tool used in making the diagnosis." ;
rdfs:range .
obo:NCIT_C78638 a rdfs:Class ;
rdfs:label "Thrombus in Catheter" ;
rdfs:comment "The development of a blood clot in a catheter." ;
rdfs:subClassOf obo:NCIT_C78254 .
obo:SCDO_0007897 a rdfs:Class ;
rdfs:label "Ethics Approval" ;
rdfs:comment "A document containing the determination of the Research Ethics Committee (REC) that the clinical study with human subject participation has been reviewed and may be conducted at a particular study site within the constraints set forth by the REC and other institutional and federal requirements. The regulations require that an REC conduct continuing review of research at intervals appropriate to the degree of risk, but not less than once a year." ;
rdfs:subClassOf obo:SCDO_0300005 , obo:SCDO_1000430 .
obo:HP_0002725 a rdfs:Class ;
rdfs:label "Systemic Lupus Erythematosus" ;
rdfs:comment "A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes." ;
rdfs:subClassOf obo:SCDO_0000267 .
obo:SCDO_0000045 a rdfs:Class ;
rdfs:label "Alpha-Adrenergic Agents" ;
rdfs:comment "Drugs that selectively bind to and activate alpha adrenergic receptors." ;
rdfs:subClassOf obo:SCDO_0000067 .
obo:SCDO_1000018 a rdf:Property ;
rdfs:label "treats" ;
rdfs:comment "A relation between a type of treatment or a specific treatment and a condition (phenotype or disease), where the type of treatment or specific treatment treat the condition." ;
rdfs:range .
obo:SCDO_0001050 a rdfs:Class ;
rdfs:label "Sickle Cell Disease Self-Efficacy Scale" ;
rdfs:comment "A nine-item self-administered questionnaire that measures disease-specific perceptions of the ability to manage day-to-day issues resulting from sickle cell disease (SCD). Items are scores according to a five-point scale ranging from 1 - Not sure at all to 5 - Very sure. Responses from individual items are summed to give an overall score with higher scores indicating greater self-efficacy." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_1000083 a rdfs:Class ;
rdfs:label "Hemoglobin S-South End" ;
rdfs:comment "An abnormal hemoglobin in which two mutations occurring in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the lysine in position 132 is replaced by asparagine." ;
rdfs:subClassOf obo:SCDO_1000082 .
obo:SCDO_1000210 a rdf:Property ;
rdfs:label "has causal or contributing genetic variation" ;
rdfs:comment "A relation between a condition (disease or phenotype) or an entity (molecular phenotype) and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation has some causal or contributing role that influences the condition or entity." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_0000660 .
obo:SCDO_0007087 a rdfs:Class ;
rdfs:label "Informed Consent" ;
rdfs:comment "Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment." ;
rdfs:subClassOf obo:NCIT_C25460 .
obo:CMO_0000057 a rdfs:Class ;
rdfs:label "Serum Creatinine Level" ;
rdfs:comment "The amount of creatinine, a catabolic product of creatine phosphate used in skeletal muscle contraction found in a specified volume of serum." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_1000230 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype DD" ;
rdfs:comment "The homozygous genotype that involves a hemoglobin D mutation in both beta-globin gene (HBB) alleles." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_1000196 a rdf:Property ;
rdfs:label "has contributing genetic variation" ;
rdfs:comment "A relation between a genotype and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation contributes to the genotype." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_0000660 .
obo:SCDO_1000222 a rdf:Property ;
rdfs:label "causes molecular phenotype" ;
rdfs:comment "A relation between a genotype and a molecular phenotype, where the genotype has a causal role for the molecular phenotype." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_1000183 .
obo:RO_0003303 a rdf:Property ;
rdfs:label "causes condition" ;
rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_1000183 .
obo:HP_0002240 a rdfs:Class ;
rdfs:label "Hepatomegaly" ;
rdfs:comment "Abnormally increased size of the liver." ;
rdfs:subClassOf obo:HP_0001392 , obo:NCIT_C115224 .
obo:SCDO_1000445 a rdfs:Class ;
rdfs:label "Aged Neutrophil Count" ;
rdfs:comment "The number of aged neutrophils in a specified volume of blood, usually 1 cubic millimeter." ;
rdfs:subClassOf obo:CMO_0000030 .
obo:SCDO_1000193 a rdf:Property ;
rdfs:label "output of diagnostic device" ;
rdfs:comment "A relation between a diagnostic measurement and a diagnostic device, where the diagnostic measurement is the output of the diagnostic device." ;
rdfs:range .
obo:HP_0001875 a rdfs:Class ;
rdfs:label "Neutropenia" ;
rdfs:comment "An abnormally low number of neutrophils in the peripheral blood." ;
rdfs:subClassOf obo:HP_0011991 .
obo:SCDO_0000304 a rdfs:Class ;
rdfs:label "Current Age" ;
rdfs:comment "The length of time that a person has lived since their birth up until the current day." ;
rdfs:subClassOf obo:NCIT_C25150 .
obo:NCIT_C84979 a rdfs:Class ;
rdfs:label "Hemoglobin Subunit Epsilon" ;
rdfs:comment "Hemoglobin subunit epsilon (147 aa, ~16 kDa) is encoded by the human HBE1 gene. This protein plays a role in the transport of oxygen to tissues of the embryo." ;
rdfs:subClassOf obo:SCDO_1000012 .
obo:SCDO_0001061 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S/D-Punjab" ;
rdfs:comment "A rare compound heterozygous hemoglobinopathy characterised by the presence of two beta globin gene variants: that of hemoglobin S (beta-6(GAG-->GTG)) and that of hemoglobin D-Punjab (beta-121(GAA-->CAA))." ;
rdfs:subClassOf obo:NCIT_C155310 .
obo:SCDO_0000469 a rdf:Property ;
rdfs:label "has clinical code" ;
rdfs:comment "A relationship between a condition (phenotype or disease) and a relevant ICD-10-CM Diagnosis Code." ;
rdfs:range .
obo:SCDO_1000172 a rdf:Property ;
rdfs:label "has causal genotype" ;
rdfs:comment "A relation between a condition (hemoglobinopathy) and the genotype that causes the condition." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_0000660 .
obo:SCDO_1000223 a rdf:Property ;
rdfs:label "has causal molecular phenotype" ;
rdfs:comment "A relation between a condition (disease such as a Hemoglobinopathy) and a molecular phenotype, where the molecular phenotype is evidence of the condition." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_0000660 .
obo:SCDO_0001364 a rdf:Property ;
rdfs:label "has mode of inheritance" ;
rdfs:comment "A relation between a particular genotype or disorder and the pattern in which the particular genotype or disorder is passed from one generation to the next." ;
rdfs:range .
obo:SCDO_0003696 a rdfs:Class ;
rdfs:label "Peripheral Blood Film" ;
rdfs:comment "A procedure in which a sample of peripheral blood is viewed under a microscope to count different circulating blood cells (red blood cells, white blood cells, platelets, etc.) and see whether the cells look normal." ;
rdfs:subClassOf obo:NCIT_C79903 .
obo:SCDO_0000071 a rdfs:Class ;
rdfs:label "Arterial Blood Gas Test" ;
rdfs:comment "A hematology assay that measures the acidity (pH) and the levels of oxygen and carbon dioxide in the blood from an artery. This test is used to check how well the lungs are able to move oxygen into the blood and remove carbon dioxide from the blood." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_1000194 a rdf:Property ;
rdfs:label "measures" ;
rdfs:comment "A relation between a diagnostic tool and the diagnostic measurement that it measures." ;
rdfs:range .
obo:SCDO_0000840 a rdfs:Class ;
rdfs:label "Osteomyelitis" ;
rdfs:comment "An inflammatory process accompanied by bone destruction and caused by an infecting microorganism." ;
rdfs:subClassOf obo:HP_0000924 , obo:IDO_0000586 .
obo:SCDO_0009532 a rdfs:Class ;
rdfs:label "Beneficence" ;
rdfs:comment "Effort made to secure the well-being of persons, maximizing possible benefits and minimizing possible harms." ;
rdfs:subClassOf obo:GSSO_003239 .
obo:SCDO_1000592 a rdfs:Class ;
rdfs:label "Hydroxyurea Use Status" ;
rdfs:comment "An indication of whether the respondent is using hydroxyurea." ;
rdfs:subClassOf obo:SCDO_1000318 , obo:SCDO_1000590 .
obo:HP_0001894 a rdfs:Class ;
rdfs:label "Thrombocytosis" ;
rdfs:comment "Thrombocythemia and thrombocytosis are conditions with a higher than normal number of platelets. The term \"thrombocythemia\" is preferred when the cause of a high platelet count isn't known. The condition sometimes is called primary or essential thrombocythemia. Increased numbers of platelets in the peripheral blood." ;
rdfs:subClassOf obo:HP_0011873 .
obo:SCDO_0000228 a rdfs:Class ;
rdfs:label "Chronic Neuropathic Pain" ;
rdfs:comment "Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat." ;
rdfs:subClassOf obo:SCDO_0000233 .
obo:SCDO_1000202 a rdf:Property ;
rdfs:label "caused by" ;
rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (e.g. environment) or condition (phenotype or disease) which could be an existing condition or an event, where the entity or second condition has a causal role for the condition being described." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_0000660 .
obo:SCDO_1000461 a rdfs:Class ;
rdfs:label "Waived Consent" ;
rdfs:comment "Consent obtained at a population level through public/community engagement where individual consenting is not feasible. This is normally done for low risk studies and/or in case of emergencies." ;
rdfs:subClassOf obo:NCIT_C25460 .
obo:NCIT_C64625 a rdfs:Class ;
rdfs:label "Pregabalin" ;
rdfs:comment "A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation." ;
rdfs:subClassOf obo:SCDO_0000809 .
obo:SCDO_1000543 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Date of Birth Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's date of birth in the format dd/mm/yyyy." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000744 a rdf:Property ;
rdfs:label "has redcap max number validation" ;
rdfs:comment "Records the maximum value that is accepted for a data element that has validation applied to it in REDCap." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000518 a rdf:Property ;
rdfs:label "has field label" ;
rdfs:comment "Records the field label of a data element." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000745 a rdf:Property ;
rdfs:label "has redcap field annotation" ;
rdfs:comment "Records the field annotations of a data element in REDCap." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000743 a rdf:Property ;
rdfs:label "has redcap min number validation" ;
rdfs:comment "Records the mainimum value that is accepted for a data element that has validation applied to it in REDCap." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000739 a rdf:Property ;
rdfs:label "order in CRF section" ;
rdfs:comment "Records the order in which a data element appears in a specific section of a specific CRF/questionnaire/instrument. This is provided in the form of a number which is relative to the order numbers of other data elements of the section." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000771 a rdf:Property ;
rdfs:label "has answer standard unit" ;
rdfs:comment "A relationship between a data element and the unit of measurement used, as a standard, for the information that is collected by the data element." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range obo:UO_0000000 .
obo:SCDO_1000735 a rdf:Property ;
rdfs:label "in CRF section" ;
rdfs:comment "Records the section of a CRF in which a data element occurs." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000526 a rdf:Property ;
rdfs:label "has answer option" ;
rdfs:comment "A relationship between a multiple choice data element and an answer option or a group of answer options that are provided to the respondent by the data element." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range .
obo:SCDO_1000749 a rdf:Property ;
rdfs:label "has field type" ;
rdfs:comment "Records a data element's field type, as per REDCap." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000736 a rdf:Property ;
rdfs:label "has calculation equation" ;
rdfs:comment "Records the calculation used to automatically calculate the value for a data element in REDCap." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000517 a rdf:Property ;
rdfs:label "has answer options text" ;
rdfs:comment "Records the answer options text for input in Redcap for a data element that provides answer options." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000742 a rdf:Property ;
rdfs:label "has branching logic" ;
rdfs:comment "Records the branching logic applied to a data element in REDCap." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000750 a rdf:Property ;
rdfs:label "in matrix group" ;
rdfs:comment "Used to record the matrix group that a data element occurs in." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000528 a rdf:Property ;
rdfs:label "collects" ;
rdfs:comment "A relationship between a data element and the type of information that is collected by that data element." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range .
obo:SCDO_1000737 a rdf:Property ;
rdfs:label "has field note" ;
rdfs:comment "Records a data element's field note (a note provided below the answer field)." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000746 a rdf:Property ;
rdfs:label "is identifier" ;
rdfs:comment "Used to show if a data element is considered an \"identifier\" (meaning it contains identifying information)." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000525 a rdf:Property ;
rdfs:label "is question type" ;
rdfs:comment "A relationship between a Clinical or Research Assessment Data Element and a Clinical or Research Assessment Question Type." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range obo:SCDO_1000475 .
obo:SCDO_1000747 a rdf:Property ;
rdfs:label "required field" ;
rdfs:comment "Used to show if a data element is a required field. \"y\" is assigned to it if the data element is a required field." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:SCDO_1000519 a rdf:Property ;
rdfs:label "has redcap variable" ;
rdfs:comment "Records the variable of the associated data element from a REDCap data capture instrument." ;
rdfs:domain obo:SCDO_1000474 ;
rdfs:range xsd:string .
obo:NCIT_C15238 a rdfs:Class ;
rdfs:label "Gene Therapy" ;
rdfs:comment "Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease." ;
rdfs:subClassOf obo:SCDO_0000301 .
obo:OGMS_0000051 a rdfs:Class ;
rdfs:label "Constitutional Genetic Disorder" ;
rdfs:comment "A genetic disorder inherited during conception that is part of all cells in the organism." ;
rdfs:subClassOf obo:OGMS_0000047 .
obo:SCDO_1000181 a rdfs:Class ;
rdfs:label "Hemoglobin E Present" ;
rdfs:comment "When the abnormal hemoglobin, hemoglobin E (HbE), has been detected in a blood sample." ;
rdfs:subClassOf obo:HP_0020061 .
obo:SCDO_1000660 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Aspartate Aminotransferase Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the level of aspartate aminotransferase in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:ICO_0000305 a rdfs:Class ;
rdfs:label "Description of Future Use" ;
rdfs:comment "A descriptive information content entity that describes future use of material or information." ;
rdfs:subClassOf obo:SCDO_1000422 .
obo:SCDO_0009445 a rdfs:Class ;
rdfs:label "Renal Papillary Necrosis" ;
rdfs:comment "A complication of kidney diseases characterized by cell death involving kidney papilla in the kidney medulla. Damages to this area may hinder the kidney to concentrate urine resulting in polyuria. Sloughed off necrotic tissue may block kidney pelvis or ureter. Necrosis of multiple renal papillae can lead to kidney failure." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_1000885 a rdfs:Class ;
rdfs:label "Next of Kin Relationship to Participant" ;
rdfs:comment "The relationship that the participant's next of kin has with the participant." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_1000316 a rdfs:Class ;
rdfs:label "Blood Flow Test" ;
rdfs:comment "A technique used to measure velocity and amount of blood flow and circulation in the living system." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_0000963 a rdfs:Class ;
rdfs:label "Radiography" ;
rdfs:comment "Examination of any part of the body for diagnostic purposes by means of x-rays or gamma rays, recording the image on a sensitized surface (such as photographic film)." ;
rdfs:subClassOf obo:OBI_0000185 .
obo:SCDO_1000192 a rdf:Property ;
rdfs:label "uses diagnostic device" ;
rdfs:comment "A relation between a diagnostic tool (test, method, assay, etc.) and a diagnostic device, where the diagnostic device is used in the application of the diagnostic tool." ;
rdfs:range .
obo:SCDO_1000327 a rdfs:Class ;
rdfs:label "Past 30-Day Smoker" ;
rdfs:comment "A person who had smoked in the past 30 days at the time of the interview, but who had not smoked every day of the past 30 days." ;
rdfs:subClassOf obo:SCDO_0000235 .
obo:HP_0001289 a rdfs:Class ;
rdfs:label "Confusion" ;
rdfs:comment "Lack of clarity and coherence of thought, perception, understanding, or action." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0001316 a rdfs:Class ;
rdfs:label "obsolete Facial Paralysis" ;
rdfs:comment "Facial paralysis is loss of facial movement because of nerve damage." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:NCIT_C103165 a rdfs:Class ;
rdfs:label "Subject Visit Type" ;
rdfs:comment "The kind of visit undertaken by the subject within a study, such as inpatient, outpatient, telephone, etc." ;
rdfs:subClassOf obo:EUPATH_0000310 .
obo:SCDO_0001097 a rdfs:Class ;
rdfs:label "Sphygmomanometer" ;
rdfs:comment "Instruments for measuring arterial blood pressure consisting of an inflatable cuff, inflating bulb, and a gauge showing the blood pressure." ;
rdfs:subClassOf obo:SCDO_0000710 .
obo:SCDO_0000474 a rdf:Property ;
rdfs:label "has output measurement" ;
rdfs:comment "A relation between a device (diagnostic device) and the recording of the output (diagnostic measurement) of the device." ;
rdfs:range .
obo:SCDO_1000630 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Mean Cell Hemoglobin Concentration Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin concentration (MCHC), as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0030050 a rdfs:Class ;
rdfs:label "Narcolepsy" ;
rdfs:comment "An abnormal phenomenon characterized by a classic tetrad of excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination, and sleep paralysis." ;
rdfs:subClassOf obo:HP_0000708 .
obo:SCDO_0000905 a rdfs:Class ;
rdfs:label "Pilot Projects" ;
rdfs:comment "Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work." ;
rdfs:subClassOf obo:SCDO_0300004 .
obo:SCDO_1000142 a rdfs:Class ;
rdfs:label "Spectrophotometry" ;
rdfs:comment "Spectrophotometry involves the use of a spectrophotometer to measure the amount of light that a sample absorbs. The instrument operates by passing a beam of light through a sample and measuring the intensity of light reaching a detector." ;
rdfs:subClassOf obo:SCDO_0000896 .
obo:HP_0000225 a rdfs:Class ;
rdfs:label "Gingival Bleeding" ;
rdfs:comment "Hemorrhage affecting the gingiva." ;
rdfs:subClassOf obo:HP_0000271 .
obo:SCDO_1000254 a rdfs:Class ;
rdfs:label "Polymerisation of Hemoglobin" ;
rdfs:comment "When deoxygenated, malfunctioning or mutated hemoglobins clump together and form a long polymer." ;
rdfs:subClassOf obo:SCDO_1000253 .
obo:SCDO_0300009 a rdfs:Class ;
rdfs:label "Data Anonymization" ;
rdfs:comment "Making information permanently non-identifiable that is associated with the identity of specific entities via encryption or other methods." ;
rdfs:subClassOf obo:SCDO_0002125 .
obo:SCDO_0007624 a rdfs:Class ;
rdfs:label "Beta Thalassemia Genotype" ;
rdfs:comment "HBB genetic variants that result in reduced or absent hemoglobin subunit beta production." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_1000184 a rdf:Property ;
rdfs:label "contributes to genotype" ;
rdfs:comment "A relationship between an entity (e.g. genetic variation such as mutation or specific allele) and a genotype, where the entity contributes to the genotype." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_1000183 .
obo:HP_0000939 a rdfs:Class ;
rdfs:label "Osteoporosis" ;
rdfs:comment "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD)." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_0000127 a rdfs:Class ;
rdfs:label "Birthplace of Maternal Grandfather" ;
rdfs:comment "The country in which the respondent's biological maternal (on the mother's side of the family) grandfather was born." ;
rdfs:subClassOf obo:SCDO_0000126 .
obo:HP_0000708 a rdfs:Class ;
rdfs:label "Behavioural Abnormality" ;
rdfs:comment "An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities." ;
rdfs:subClassOf obo:HP_0012638 .
obo:HP_0001254 a rdfs:Class ;
rdfs:label "Lethargy" ;
rdfs:comment "A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0000056 a rdfs:Class ;
rdfs:label "Annual Family Income" ;
rdfs:comment "The respondent's total family income from the last calendar year." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0001090 , obo:SCDO_1000157 .
obo:SCDO_1000693 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin S Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin S." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000240 a rdfs:Class ;
rdfs:label "Reduced or Absent Hemoglobin A" ;
rdfs:comment "Either a decrease in the proportion of hemoglobin A to below 96-98% of all hemoglobin, or a complete lack of hemoglobin A production." ;
rdfs:subClassOf obo:SCDO_1000061 .
obo:EUPATH_0000050 a rdfs:Class ;
rdfs:label "Routine Clinical Visit" ;
rdfs:comment "A clinical visit that is primarily for a regular examination." ;
rdfs:subClassOf obo:NCIT_C103165 .
obo:UO_0000190 a rdfs:Class ;
rdfs:label "Ratio" ;
rdfs:comment "A dimensionless unit which denotes an amount or magnitude of one quantity relative to another." ;
rdfs:subClassOf obo:UO_0000186 .
obo:SCDO_1000576 a rdfs:Class ;
rdfs:label "Diagnostic Measurement Descriptor" ;
rdfs:comment "A piece of information that further describes a diagnostic measurement." ;
rdfs:subClassOf obo:SCDO_0000379 .
obo:SCDO_0000256 a rdfs:Class ;
rdfs:label "obsolete Clinical Trial, Phase II" ;
rdfs:comment "'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on several hundred volunteers, including a limited number of patients, and conducted over a period of about two years in either the United States or a foreign country. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000254 .
obo:DUO_0000029 a rdfs:Class ;
rdfs:label "Return to Database or Resource" ;
rdfs:comment "This requirement indicates that the requestor must return derived/enriched data to the database/resource." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:EUPATH_0000310 a rdfs:Class ;
rdfs:label "Information on Observation Details" ;
rdfs:comment "An information content entity that is about a clinical visit." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:NCIT_C16495 a rdfs:Class ;
rdfs:label "Demographic Factor" ;
rdfs:comment "The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income)." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:NCIT_C34941 a rdfs:Class ;
rdfs:label "Pregnancy Complication" ;
rdfs:comment "The co-occurrence of pregnancy and a disease. The disease may precede or follow conception and it may or may not have a deleterious effect on the pregnant woman or fetus." ;
rdfs:subClassOf obo:NCIT_C2959 .
obo:MP_0002081 a rdfs:Class ;
rdfs:label "Perinatal Death" ;
rdfs:comment "Death anytime within the perinatal period." ;
rdfs:subClassOf obo:HP_0001197 .
obo:SCDO_0001288 a rdfs:Class ;
rdfs:label "Cluster Headache" ;
rdfs:comment "A primary headache disorder that is characterized by severe, strictly unilateral pain which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial sweating, eyelid edema, and miosis." ;
rdfs:subClassOf obo:HP_0012638 , obo:SCDO_0000851 , obo:SCDO_1000000 .
obo:SCDO_1000030 a rdfs:Class ;
rdfs:label "obsolete IC (inferred by curator)" ;
rdfs:comment "'Used for those cases where an annotation is not supported by any direct evidence, but can be reasonably inferred by a curator from other annotations, for which evidence is available. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:SCDO_1000789 a rdfs:Class ;
rdfs:label "D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000325 .
obo:SCDO_1000785 a rdf:Property ;
rdfs:label "code requires phenotype" ;
rdfs:comment "A relationship between a clinical code (such as ICD10 code) and a Phenotype, where the code can only be applied in instances where the phenotype is present." ;
rdfs:range .
obo:SCDO_1000175 a rdf:Property ;
rdfs:label "is ICD-10-CM code type" ;
rdfs:comment "An object property that specifies the type of an ICD-10-CM code, whether Billable or Non-Billable." ;
rdfs:domain obo:SCDO_0000607 ;
rdfs:range obo:SCDO_1000100 .
obo:SCDO_1000176 a rdf:Property ;
rdfs:label "requires additional code" ;
rdfs:comment "An indication of whether or not a clinical code requires an additional code to be specified with it. Annotation is either \"yes\", \"no\" or \"if applicable, X\", where X is the name of a diagnosis for which a code should be provided if it is applicable." ;
rdfs:domain obo:SCDO_0000607 ;
rdfs:range xsd:string .
obo:SCDO_0000927 a rdfs:Class ;
rdfs:label "PROMIS Adult Profile 29" ;
rdfs:comment "This protocol includes 29 self-administered quality of life-type questions from the PROMIS Profile 29 for adults. The quality of life questions include physical function, anxiety, depression, fatigue, sleep disturbance, ability to participate in social roles and activities, and pain intensity over the past 7 days. Each question, except for the pain intensity question, is measured on a 5-point scale." ;
rdfs:subClassOf obo:NCIT_C102988 .
obo:SCDO_0001107 a rdfs:Class ;
rdfs:label "Stigma" ;
rdfs:comment "A perceived attribute that is deeply discrediting and is considered to be a violation of social norms." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:SCDO_0000465 a rdfs:Class ;
rdfs:label "Growth Delay" ;
rdfs:comment "A deficiency or slowing down of growth pre- and postnatally greater than two standard deviations from the age- and sex-related normal." ;
rdfs:subClassOf obo:HP_0001507 , obo:SCDO_0000954 .
obo:SCDO_0000164 a rdfs:Class ;
rdfs:label "Brief RCOPE" ;
rdfs:comment "Brief RCOPE is a 14-item instrument that measures religious coping with major life stressors. Responses on the Brief RCOPE indicate the frequency with which participants have used R/S coping behaviors on a Likert scale of 1 (not at all) to 4 (a great deal.) The scale has been used to examine positive and negative religious coping, including in teens with SCD." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:NCIT_C95536 a rdfs:Class ;
rdfs:label "Alpha Thalassemia Silent Carrier" ;
rdfs:comment "A condition in which a person has reduced protein production from one of the four alpha-globin alleles." ;
rdfs:subClassOf obo:SCDO_0000551 .
obo:SCDO_1000218 a rdf:Property ;
rdfs:label "has manifestation" ;
rdfs:comment "A relationship that holds between a condition such as a disease (hemoglobinopathy) and a phenotype (i.e. manifestation), where the phenotype is evidence of the condition." ;
rdfs:range ;
rdfs:subPropertyOf obo:RO_0002200 .
obo:SCDO_1000276 a rdfs:Class ;
rdfs:label "Abnormal Hemoglobin Level in SCD" ;
rdfs:comment "An abnormal level of hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD)." ;
rdfs:subClassOf obo:SCDO_1000060 .
obo:SCDO_0000315 a rdfs:Class ;
rdfs:label "D57.1 Sickle-cell disease without crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000311 .
obo:SCDO_0001232 a rdfs:Class ;
rdfs:label "Vineland Adaptive Behavior Scales, Second Edition (Vineland-II)" ;
rdfs:comment "A parent or caregiver questionnaire administered as part of a structured interview that measures day-to-day performance on communication, daily living, socialization, and motor skills. Standard scores can be derived for communication, daily living, socialization, and motor skills subtests or combined to create an Adaptive Behavior Composite (ABC)." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_0000325 a rdfs:Class ;
rdfs:label "D57.41 Sickle-cell thalassemia, unspecified, with crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000323 .
obo:SCDO_0000938 a rdfs:Class ;
rdfs:label "Psychosocial Deprivation" ;
rdfs:comment "The absence of appropriate stimuli in the physical or social environment which are necessary for the emotional, social, and intellectual development of the individual." ;
rdfs:subClassOf obo:SCDO_0000299 , obo:SCDO_0000746 .
obo:NCIT_C16453 a rdfs:Class ;
rdfs:label "Community" ;
rdfs:comment "A set of people with some shared element. The substance of shared element varies widely, from geography to a situation to interest to lives and values. The term is widely used to evoke sense of collectivity." ;
rdfs:subClassOf obo:SCDO_0001082 .
obo:SCDO_0000326 a rdfs:Class ;
rdfs:label "D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000325 .
obo:SCDO_1000164 a rdfs:Class ;
rdfs:label "Sickle Cell Disease A/Jamaica Plain" ;
rdfs:comment "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta68 Leu > Phe mutation.The other beta globin allele produces normal beta globin chains." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000211 .
obo:SCDO_0000775 a rdfs:Class ;
rdfs:label "Multicenter Studies as Topic" ;
rdfs:comment "Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:HP_0010885 a rdfs:Class ;
rdfs:label "Osteonecrosis" ;
rdfs:comment "A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply." ;
rdfs:subClassOf obo:HP_0000924 , obo:SCDO_0000954 .
obo:ExO_0000034 a rdfs:Class ;
rdfs:label "Occupation" ;
rdfs:comment "An individual attribute that is the usual or principal work or business of an individual." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_0001090 , obo:SCDO_1000157 .
obo:SCDO_0000111 a rdfs:Class ;
rdfs:label "Beta Thalassemia" ;
rdfs:comment "A hemoglobinopathy characterized by the reduced (beta plus) or absent (beta zero) synthesis of the beta globin chains of hemoglobin, resulting in variable outcomes ranging from severe anemia to clinically asymptomatic individuals." ;
rdfs:subClassOf obo:NCIT_C35069 , obo:OGMS_0000051 .
obo:HP_0000007 a rdfs:Class ;
rdfs:label "Autosomal Recessive" ;
rdfs:comment "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygous (two copies of the same mutant allele) or compound heterozygous (whereby each copy of a gene has a distinct mutant allele)." ;
rdfs:subClassOf obo:HP_0000005 .
obo:DRON_00017565 a rdfs:Class ;
rdfs:label "Xylometazoline" ;
rdfs:comment "A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion." ;
rdfs:subClassOf obo:SCDO_0000791 .
obo:SCDO_1000558 a rdfs:Class ;
rdfs:label "Date of SCD Diagnosis" ;
rdfs:comment "The date on which a diagnosis of sickle cell disease was made." ;
rdfs:subClassOf obo:NCIT_C164339 .
obo:SCDO_0000804 a rdfs:Class ;
rdfs:label "NIH Stroke Scale (NIHSS)" ;
rdfs:comment "A physical assessment of the various symptoms associated with a stroke, consisting of 11 categories. For each category, the test administrator asks the respondent to perform an activity or respond to stimuli. Respondents receive a score for each category based upon their ability to complete the activity or respond to the action. Each score typically ranges from 0 to 3. Each category of the NIHSS is designed to determine the respondent's level of consciousness (LOC), visual, motor, or language ability." ;
rdfs:subClassOf obo:SCDO_0001112 .
obo:CMO_0000364 a rdfs:Class ;
rdfs:label "Complete Blood Count" ;
rdfs:comment "The calculation of the cellular elements of the blood, usually including cell counts for white and red blood cells and platelets." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_0000443 a rdfs:Class ;
rdfs:label "Genetic Counseling" ;
rdfs:comment "An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered." ;
rdfs:subClassOf obo:SCDO_0000447 .
obo:SCDO_0001132 a rdfs:Class ;
rdfs:label "Sustained and Selective Attention Diagnostic Instrument" ;
rdfs:comment "A computerized test for the assessment of visual attention problems in individuals ages 8 years old and older." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_0008625 a rdfs:Class ;
rdfs:label "Right Upper Quadrant Syndrome" ;
rdfs:comment "Characterized by pain and discomfort in the right upper quadrant (RUQ) of the abdomen caused by a number of possible aetiologies in sickle cell disease. Causes of RUQ pain may be divided into pain originating from the liver or gall bladder versus other origins of abdominal pain in that region." ;
rdfs:subClassOf obo:SCDO_0000895 .
obo:SCDO_0000495 a rdfs:Class ;
rdfs:label "Health Utility" ;
rdfs:comment "Utility measures of health related quality of life are preference values that patients attach to their overall health status. In clinical trials, utility measures summarize both positive and negative effects of an intervention into one value between 0 (equal to death) and 1 (equal to perfect health). These measures allow for comparison of patient outcomes of different diseases, and for comparison between various health care interventions. There are 2 different approaches to utility measurement." ;
rdfs:subClassOf obo:SCDO_0000948 .
obo:DUO_0000024 a rdfs:Class ;
rdfs:label "Publication Moratorium" ;
rdfs:comment "This should be coupled with a date specified as ISO8601" ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_0000611 a rdfs:Class ;
rdfs:label "Illness Perception Questionnaire Revised (IPQ-R)" ;
rdfs:comment "The IPQ-R is an 84-item self-completed instrument developed to provide a quantitative measurement of the components of illness representations, as described by Leventhal's Common-Sense Model (CSM) of selfregulation it is divided into 3 sections: identity subscale (14 symptoms), causal subscale (18 causes), and a third section which contains 7 subscales, including consequences, timeline acute/chronic and cyclical, personal and treatment control/cure, illness coherence, and emotional representations. The questionnaire wording can be adapted to the specific illness by replacing the word illness with the name of the condition. For the identity subscale, respondents are asked if they have experienced a number of symptoms since their illness, and if they feel the symptoms are related to their current illness. Response is by circling 'yes' or 'no' to each question. Responses are then summed to give an overall score. For the causal subscale, respondents are asked what they perceive to be the cause of their illness and are asked to respond to each of the listed causes using a 5-point Likert style scale, ranging from strongly disagree to strongly agree. Respondents are also asked to rank the 3 most important factors believed to be the cause of their illness. The third section (7 subscales) is scored by summing responses to each item is on a 5-point Likert style scale, ranging from strongly disagree to strongly agree. All items for each of the subscales are summed to give an overall score. High scores on the identity, consequences, timeline acute/chronic and cyclical subscales represent strongly held beliefs about the number of symptoms attributed, the negative consequences, and the chronicity and cyclical nature of the illness. High scores on the personal and treatment control and coherence subscales represent positive beliefs about controllability and a personal understanding of the illness." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:SCDO_0007212 a rdfs:Class ;
rdfs:label "obsolete Other Molecules" ;
rdfs:comment "'Other molecules are complexes which do not contain protein or RNA, including lipids, carbohydrates, etc.'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0020060 a rdfs:Class ;
rdfs:label "Decreased Red Blood Cell Count" ;
rdfs:comment "An abnormal reduction below the normal number of red blood cells per volume in the circulation." ;
rdfs:subClassOf obo:HP_0020058 .
obo:SCDO_0001017 a rdfs:Class ;
rdfs:label "Rural Location" ;
rdfs:comment "An open swath of land that has few homes or other buildings, and not very many people." ;
rdfs:subClassOf obo:GAZ_00000448 , obo:SCDO_0000496 .
obo:NCIT_C152089 a rdfs:Class ;
rdfs:label "Voxelotor" ;
rdfs:comment "An orally bioavailable modulator and stabilizer of sickle cell hemoglobin (HbS), with potential use in the treatment of sickle cell disease (SCD). Upon administration, voxelotor targets and covalently binds to the N-terminal valine of the alpha chain of HbS. This stabilizes HbS, thereby improving oxygen binding affinity. The binding of voxelotor to HbS prevents HbS polymerization, reduces sickling, decreases red blood cell (RBC) damage and increases the half-life of RBCs. This improves blood flow and decreases hemolytic anemia." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0000922 .
obo:SCDO_1000490 a rdfs:Class ;
rdfs:label "Consent Status" ;
rdfs:comment "The situation, with regard to obtaining consent from a respondent, at a particular stage during a process." ;
rdfs:subClassOf obo:SCDO_0007597 .
obo:SCDO_0000941 a rdfs:Class ;
rdfs:label "obsolete Publication Type" ;
rdfs:comment "'Describes the type of material the article represents (e.g., Review, Clinical Trial, Retracted Publication, Letter); see the PubMed Publication Types, e.g., review[pt]. Publication Types are arranged hierarchically with more specific terms arranged beneath broader terms. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:HP_0500015 a rdfs:Class ;
rdfs:label "Abnormal Cardiac Test" ;
rdfs:comment "Abnormal test result of cardiovascular physiology." ;
rdfs:subClassOf obo:HP_0001626 .
obo:NCIT_C3671 a rdfs:Class ;
rdfs:label "Injury" ;
rdfs:comment "Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_1000783 a rdfs:Class ;
rdfs:label "Normal Hemoglobin Concentration" ;
rdfs:comment "When there is no deviation from the normal concentration of hemoglobin in the blood." ;
rdfs:subClassOf obo:SCDO_0009613 , obo:SCDO_1000821 .
obo:SCDO_0001327 a rdfs:Class ;
rdfs:label "Fluorescein Angiography" ;
rdfs:comment "Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature." ;
rdfs:subClassOf obo:OBI_0000185 .
obo:SCDO_1000124 a rdfs:Class ;
rdfs:label "Kamba" ;
rdfs:comment "The Kamba ethnic group, also known as Akamba is one of the five largest ethnic groups in Kenya. They are Bantu-speaking people and primarily agriculturists." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000245 a rdfs:Class ;
rdfs:label "Clinical Coding" ;
rdfs:comment "Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)" ;
rdfs:subClassOf obo:SCDO_0000738 .
obo:HP_0000271 a rdfs:Class ;
rdfs:label "Abnormality of the Face" ;
rdfs:comment "An abnormality of the face." ;
rdfs:subClassOf obo:HP_0000118 .
obo:NCIT_C62200 a rdfs:Class ;
rdfs:label "Point Mutation" ;
rdfs:comment "A small scale mutation caused by the substitution of a single nucleotide for another nucleotide." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_0001208 a rdfs:Class ;
rdfs:label "deprecated Urinary System" ;
rdfs:comment "The organs and passageways concerned with the production and excretion of urine, including the kidneys, ureters, urinary bladder, and urethra." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:NCIT_C16576 a rdfs:Class ;
rdfs:label "Female" ;
rdfs:comment "A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:MP_0010163 a rdfs:Class ;
rdfs:label "Hemolysis" ;
rdfs:comment "Destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity." ;
rdfs:subClassOf obo:HP_0020054 .
obo:SCDO_1000170 a rdfs:Class ;
rdfs:label "Diagnosis Guideline" ;
rdfs:comment "A directive information entity that specifies how to establish a diagnosis based on clinical findings." ;
rdfs:subClassOf obo:SCDO_1000160 .
obo:SCDO_0005191 a rdfs:Class ;
rdfs:label "Hyperhemolysis" ;
rdfs:comment "An increase in the rate of hemolysis, in conjunction with specific clinical complications of sickle cell disease." ;
rdfs:subClassOf obo:HP_0001392 , obo:MP_0010163 , obo:NCIT_C115224 , obo:SCDO_0000895 .
obo:SCDO_0000384 a rdfs:Class ;
rdfs:label "Diffusion Capacity of Lung" ;
rdfs:comment "The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the blood-air barrier." ;
rdfs:subClassOf obo:CMO_0000094 .
obo:SCDO_1000045 a rdfs:Class ;
rdfs:label "HBB, VAL23ILE" ;
rdfs:comment "A mutation where the valine in position 23 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. When compounded with the HbS mutation in the same gene, the sickling Hemoglobin S-Antilles is produced." ;
rdfs:subClassOf obo:SCDO_0009786 .
obo:SCDO_1000217 a rdf:Property ;
rdfs:label "causes or contributes to molecular phenotype" ;
rdfs:comment "A relation between an entity (genotype) and a molecular phenotype, where the entity has some causal or contributing role that influences the molecular phenotype." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_1000183 .
obo:RO_0003302 a rdf:Property ;
rdfs:label "causes or contributes to condition" ;
rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." ;
rdfs:range ;
rdfs:subPropertyOf obo:SCDO_1000183 .
obo:SCDO_1000423 a rdfs:Class ;
rdfs:label "Participant Withdrawal Policy" ;
rdfs:comment "The policy regarding participants' right to withdraw their participation in a study." ;
rdfs:subClassOf obo:SCDO_1000422 , obo:SCDO_1000424 .
obo:SCDO_0000294 a rdfs:Class ;
rdfs:label "Cost of Illness" ;
rdfs:comment "The personal cost of disease which may be economic, social, or psychological. The cost of illness may be reflected in absenteeism, productivity, response to treatment, peace of mind, or quality of life. It differs from health care costs, the societal cost of providing services related to the delivery of health care." ;
rdfs:subClassOf obo:SCDO_0000496 , obo:SCDO_0000746 .
obo:SCDO_0006847 a rdfs:Class ;
rdfs:label "Aplastic Crisis" ;
rdfs:comment "An acute form of acquired red cell aplasia. A significant change in blood picture is observed, characterised by a precipitous fall in the haemoglobin level (>20 g/l beyond steady state level) and reduced (<1%) or absent reticulocytes in the peripheral blood. The total white blood cell or platelet counts may or may not be affected. In addition, there is no significant increase in the unconjugated fraction of serum bilirubin.The most common cause is infection by parvovirus B19, a DNA virus that replicates inside immature red blood cells in the bone marrow, resulting in severe anaemia (hemoglobin levels well below steady state) and low reticulocyte count. It is rarely recurrent." ;
rdfs:subClassOf obo:SCDO_1000000 .
obo:SCDO_1000016 a rdfs:Class ;
rdfs:label "Hemoglobin O-Arab" ;
rdfs:comment "An abnormal hemoglobin that results from the substitution of glutamic acid with lysine at position 121 of the beta chain." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_0003807 .
obo:SCDO_1000085 a rdfs:Class ;
rdfs:label "Hemoglobin Quebec Chori" ;
rdfs:comment "An abnormal hemoglobin in which a threonine is replaced by an isoleucine residue at the eighty-seventh position of beta chains. It migrates like HbA but promotes sickling." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_0003807 .
obo:SCDO_0000876 a rdfs:Class ;
rdfs:label "Pediatric School Performance Measure" ;
rdfs:comment "A questionnaire to assess educational performance and learning accommodations." ;
rdfs:subClassOf obo:SCDO_0000951 , obo:SCDO_1000297 .
obo:SCDO_0000981 a rdfs:Class ;
rdfs:label "Religion" ;
rdfs:comment "A set of beliefs concerning the nature, cause, and purpose of the universe, especially when considered as the creation of a superhuman agency. It usually involves devotional and ritual observances and often a moral code for the conduct of human affairs." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_0000299 .
obo:SCDO_0000454 a rdfs:Class ;
rdfs:label "Glaucoma (Secondary to Presence of Blood in the Anterior Chamber of the Eye)" ;
rdfs:comment "Elevated ocular pressure caused by clogging of the trabecular meshwork and by impaired aqueous humor outflow from blood in the anterior chamber (due to ocular trauma or surgery)." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:HP_0011904 a rdfs:Class ;
rdfs:label "Increased Hemoglobin F" ;
rdfs:comment "Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobiin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent." ;
rdfs:subClassOf obo:HP_0020063 , obo:SCDO_1000061 .
obo:HP_0000823 a rdfs:Class ;
rdfs:label "Delayed Puberty" ;
rdfs:comment "Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty." ;
rdfs:subClassOf obo:HP_0000818 , obo:HP_0001507 , obo:SCDO_0000954 .
obo:NCIT_C168823 a rdfs:Class ;
rdfs:label "Year of Diagnosis" ;
rdfs:comment "The year when a diagnosis was assigned to an individual's condition." ;
rdfs:subClassOf obo:SCDO_1000538 .
obo:SCDO_0000437 a rdfs:Class ;
rdfs:label "Epidemiologic Studies" ;
rdfs:comment "Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are case-control studies; cohort studies; and cross-sectional studies." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:HP_0012330 a rdfs:Class ;
rdfs:label "Pyelonephritis" ;
rdfs:comment "An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices." ;
rdfs:subClassOf obo:HP_0000123 .
obo:UO_0000316 a rdfs:Class ;
rdfs:label "cells per microliter" ;
rdfs:comment "A unit of cell concentration which is equal to one cell in a volume of 1 microliter." ;
rdfs:subClassOf obo:UO_0000200 .
obo:SCDO_0001129 a rdfs:Class ;
rdfs:label "Supportive Therapeutics" ;
rdfs:comment "Measures aimed at providing appropriate supportive and rehabilitative services to minimize morbidity and maximize quality of life after a long-term disease or injury is present." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:SCDO_1000532 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Date of Signing Consent Question" ;
rdfs:comment "The Sickle in Africa core data element that records the date on which the respondent signed the consent form for the relevant study." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000799 a rdfs:Class ;
rdfs:label "Neurocognitive Impairment" ;
rdfs:comment "An invisible complication of sickle cell anemia (SSA) that defies detection by imaging and other routine diagnostic methods. Impaired neurocognitive function in seemingly neurologically intact patients is not related to vasoocclusion or hemolysis. It is detected by neuropsychiatric and neurobehavioral testing and is associated with anemia and age." ;
rdfs:subClassOf obo:HP_0012638 , obo:SCDO_0000895 .
obo:HP_0010628 a rdfs:Class ;
rdfs:label "Facial Nerve Palsy" ;
rdfs:comment "Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form." ;
rdfs:subClassOf obo:HP_0000271 .
obo:SCDO_1000219 a rdf:Property ;
rdfs:label "diagnosed by" ;
rdfs:comment "A relation between a condition that is a diagnosis and a phenotype used in making the diagnosis." ;
rdfs:range .
obo:SCDO_0000066 a rdfs:Class ;
rdfs:label "Antihistamine" ;
rdfs:comment "Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001133 .
obo:SCDO_0004444 a rdfs:Class ;
rdfs:label "Delta Beta Globin Fusion Chain" ;
rdfs:comment "The protein product of the fusion of the gene products of the HBD and HBB genes that causes the mutation which causes the Hemoglobin Lepore Trait." ;
rdfs:subClassOf obo:SCDO_1000012 .
obo:SCDO_0001113 a rdfs:Class ;
rdfs:label "Stroke Impact Scale (SIS)" ;
rdfs:comment "This questionnaire includes 59 proxy- or self-report items in 8 domains that assess multidimensional stroke outcomes in adults." ;
rdfs:subClassOf obo:SCDO_0001339 .
obo:SCDO_1000755 a rdfs:Class ;
rdfs:label "Oral Temperature" ;
rdfs:comment "The temperature of the oral cavity." ;
rdfs:subClassOf obo:CMO_0000015 .
obo:SCDO_0006339 a rdfs:Class ;
rdfs:label "Research" ;
rdfs:comment "Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:NCIT_C62198 a rdfs:Class ;
rdfs:label "Nonsense Mutation" ;
rdfs:comment "A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein." ;
rdfs:subClassOf obo:NCIT_C62200 .
obo:SCDO_0000019 a rdfs:Class ;
rdfs:label "Acute Sickle Cell Pain Management" ;
rdfs:comment "Sickle cell pain management that aims to heal the acute process." ;
rdfs:subClassOf obo:SCDO_0001052 .
obo:NCIT_C84983 a rdfs:Class ;
rdfs:label "Hemoglobin Subunit Beta" ;
rdfs:comment "Hemoglobin subunit beta (147 aa, ~16 kDa) is encoded by the human HBB gene. This protein plays a role in the transport of oxygen to tissues of the adult body." ;
rdfs:subClassOf obo:SCDO_1000012 .
obo:SCDO_1000568 a rdfs:Class ;
rdfs:label "Year of SCD Diagnosis" ;
rdfs:comment "The year in which a sickle cell disease diagnosis was made." ;
rdfs:subClassOf obo:NCIT_C168823 .
obo:UO_0000280 a rdfs:Class ;
rdfs:label "Rate Unit" ;
rdfs:comment "A unit which represents a standard measurement occurrence of a process per unit time." ;
rdfs:subClassOf obo:UO_0000000 .
obo:VO_0000675 a rdfs:Class ;
rdfs:label "Streptococcus Pneumoniae Vaccine" ;
rdfs:comment "A Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases." ;
rdfs:subClassOf obo:VO_0000001 .
obo:NCIT_C67244 a rdfs:Class ;
rdfs:label "thousand cells per microliter" ;
rdfs:comment "A unit of cell concentration expressed as a number of cells in thousands per unit volume equal to one microliter." ;
rdfs:subClassOf obo:UO_0000316 .
obo:SCDO_0000448 a rdfs:Class ;
rdfs:label "Genetic Technique" ;
rdfs:comment "Chromosomal, biochemical, intracellular, and other methods used in the study of genetics." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:SCDO_0000331 a rdfs:Class ;
rdfs:label "D57.81 Other sickle-cell disorders with crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000329 .
obo:SCDO_0001035 a rdfs:Class ;
rdfs:label "Self Efficacy" ;
rdfs:comment "Cognitive mechanism based on expectations or beliefs about one's ability to perform actions necessary to produce a given effect." ;
rdfs:subClassOf obo:SCDO_0000286 .
obo:SCDO_0000898 a rdfs:Class ;
rdfs:label "Physical Examination" ;
rdfs:comment "Systematic and thorough inspection of the patient for physical signs of disease or abnormality." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:SCDO_1000292 a rdfs:Class ;
rdfs:label "Normal Hemoglobin F Level" ;
rdfs:comment "When the level of hemoglobin F detected in a sample of blood falls in the normal range for HbF." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_1000547 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Self-Reported Age Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's age, as reported by the respondent in years." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0002138 a rdfs:Class ;
rdfs:label "Subarachnoid Hemorrhage" ;
rdfs:comment "Hemorrhage occurring between the arachnoid mater and the pia mater." ;
rdfs:subClassOf obo:HP_0002170 .
obo:SCDO_1000220 a rdf:Property ;
rdfs:label "diagnosed using measurement" ;
rdfs:comment "A relation between an Abnormal Phenotype that is a diagnosis and a Diagnostic Measurement or Diagnostic Device Visual Output used in making the diagnosis." ;
rdfs:range .
obo:NBO_0000131 a rdfs:Class ;
rdfs:label "Alcohol Intake" ;
rdfs:comment "A drinking behavior associated with the intake of alcohol." ;
rdfs:subClassOf obo:SCDO_0000487 .
obo:HP_0000118 a rdfs:Class ;
rdfs:label "Abnormal Phenotype" ;
rdfs:comment "A phenotype that shows detectable differences from normal." ;
rdfs:subClassOf obo:OGMS_0000023 .
obo:OBI_0002146 a rdfs:Class ;
rdfs:label "HIV Antibody Test" ;
rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) antigens." ;
rdfs:subClassOf obo:SCDO_0000571 .
obo:SCDO_0000487 a rdfs:Class ;
rdfs:label "Health Behaviour" ;
rdfs:comment "Individual lifestyle and behavior which may or may not enhance or maintain good health." ;
rdfs:subClassOf obo:SCDO_0000435 .
obo:SCDO_1000439 a rdfs:Class ;
rdfs:label "Elevated Serum iFABP Level" ;
rdfs:comment "An increased circulating blood concentration of the intestinal fatty-acid binding protein." ;
rdfs:subClassOf obo:HP_0010876 .
obo:SCDO_0001385 a rdfs:Class ;
rdfs:label "Absence of Alpha Globin Synthesis with Gamma Globin Synthesis" ;
rdfs:comment "The state, in utero or shortly after birth, in which all four alpha globin genes are deleted or inactivated resulting in absent alpha globin synthesis. If gamma globin synthesis persists, then the resulting phenotype is hemoglobin Barts (four gamma chains) and hemoglobin Bart hydrops fetalis." ;
rdfs:subClassOf obo:SCDO_0001384 .
obo:HP_0001909 a rdfs:Class ;
rdfs:label "Leukaemia" ;
rdfs:comment "A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes." ;
rdfs:subClassOf obo:OBI_1110053 .
obo:NCIT_C123667 a rdfs:Class ;
rdfs:label "Global Mental Status Screener - Adult" ;
rdfs:comment "A standardized rating scale developed by Ziad Nasreddine in 1996 to screen for mild cognitive dysfunction and impairment. This instrument assesses the following cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation" ;
rdfs:subClassOf obo:SCDO_0000455 .
obo:SCDO_0000320 a rdfs:Class ;
rdfs:label "D57.212 Sickle-cell/Hb-C disease with splenic sequestration" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000318 .
obo:HP_0001265 a rdfs:Class ;
rdfs:label "Hyporeflexia" ;
rdfs:comment "Reduction of neurologic reflexes such as the knee-jerk reaction." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0000272 a rdfs:Class ;
rdfs:label "obsolete Compound Heterozygous Hemoglobinopathy" ;
rdfs:comment "'Compound heterozygosity in medical genetics is the condition of having two heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000535 a rdfs:Class ;
rdfs:label "Consent Form Uploaded" ;
rdfs:comment "An indication of whether the consent form used for obtaining informed consent from the respondent has been uploaded to the relevant electronic system." ;
rdfs:subClassOf obo:SCDO_1000490 .
obo:SCDO_0000966 a rdfs:Class ;
rdfs:label "Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen)" ;
rdfs:comment "The Rapid Estimate of Adolescent Literacy or REALM-Teen is a valid, reliable, easy-to-administer tool that will allow health professionals to screen youth in grades 6-12 for below-grade reading. The REALM-Teen is a reading recognition instrument, modeled after the Rapid Estimate of Adult Literacy in Medicine (REALM), the most commonly used tool to screen adults for low literacy in health care settings. The REALM-Teen is a reading recognition instrument which measures an individual's ability to pronounce words in ascending order of difficulty. All test words are commonly used adolescent health terms." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:SCDO_1000812 a rdfs:Class ;
rdfs:label "Normal Metabolism/Homeostasis Phenotype" ;
rdfs:comment "A phenotype of the body's metabolism or homeostasis that is not clinically abnormal." ;
rdfs:subClassOf obo:MP_0005376 .
obo:SCDO_1000331 a rdfs:Class ;
rdfs:label "Epilepsy Screener - Child/Proxy" ;
rdfs:comment "A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in family members, including children and those who are deceased." ;
rdfs:subClassOf obo:SCDO_0000440 .
obo:SCDO_0000078 a rdfs:Class ;
rdfs:label "deprecated ASCQ-Me Score" ;
rdfs:comment "The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:NCIT_C50474 a rdfs:Class ;
rdfs:label "Bradypnea" ;
rdfs:comment "Abnormal decrease of rate of breathing." ;
rdfs:subClassOf obo:HP_0002086 .
obo:HP_0100601 a rdfs:Class ;
rdfs:label "Eclampsia" ;
rdfs:comment "An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders." ;
rdfs:subClassOf obo:NCIT_C34941 , obo:SCDO_1000371 .
obo:DOID_1584 a rdfs:Class ;
rdfs:label "Acute Chest Syndrome" ;
rdfs:comment "A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion." ;
rdfs:subClassOf obo:HP_0002086 , obo:SCDO_1000000 .
obo:HP_0000097 a rdfs:Class ;
rdfs:label "Focal Segmental Glomerulosclerosis" ;
rdfs:comment "Segmental accumulation of scar tissue in individual (but not all) glomeruli." ;
rdfs:subClassOf obo:HP_0000096 .
obo:HP_0012819 a rdfs:Class ;
rdfs:label "Myocarditis" ;
rdfs:comment "Inflammation of the myocardium." ;
rdfs:subClassOf obo:HP_0030680 .
obo:SCDO_0001374 a rdfs:Class ;
rdfs:label "obsolete heterozygous beta c mutation" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000001 a rdfs:Class ;
rdfs:label "deprecated Research Subject ID" ;
rdfs:comment "A unique identifier generated either manually or electronically when adding a subject to a study." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0003573 a rdfs:Class ;
rdfs:label "Increased Total Bilirubin" ;
rdfs:comment "Increased concentration of total (conjugated and unconjugated) bilirubin in the blood." ;
rdfs:subClassOf obo:NCIT_C27088 .
obo:NCIT_C84481 a rdfs:Class ;
rdfs:label "Hereditary Hemochromatosis" ;
rdfs:comment "An inherited metabolic disorder characterized by iron accumulation in the tissues." ;
rdfs:subClassOf obo:NCIT_C78393 .
obo:HP_0025031 a rdfs:Class ;
rdfs:label "Abnormality of the Digestive System" ;
rdfs:comment "Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0001088 a rdfs:Class ;
rdfs:label "Social Support" ;
rdfs:comment "Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc." ;
rdfs:subClassOf obo:SCDO_0001083 .
obo:SCDO_1000258 a rdfs:Class ;
rdfs:label "Practice Guidelines: Management of Pain in Sickle Cell Disease" ;
rdfs:comment "A comprehensive guideline to aid physicians and other health care professionals in the management of patients with acute and chronic pain associated with sickle cell disease (SCD). The guideline covers the following information: an overview of the disease, the types and characteristics of pain associated with the disease, recommendations for pain assessment, methods for treatment of pain and a discussion of pain in the various developmental stages. It also includes discussions of pain assessment instruments." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:HP_0001250 a rdfs:Class ;
rdfs:label "Seizure" ;
rdfs:comment "Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0000582 a rdfs:Class ;
rdfs:label "Hydroxyurea-Induced Cutaneous Adverse Event" ;
rdfs:comment "A hydroxyurea-induced adverse event that has an outcome relating to or affecting the skin." ;
rdfs:subClassOf obo:SCDO_0000581 .
obo:SCDO_1000199 a rdf:Property ;
rdfs:label "induced by" ;
rdfs:comment "A condition (phenotype or disease) or event (adverse event) induced by an entity (e.g. a drug) or activity (e.g. exercise)." ;
rdfs:range .
obo:NCIT_C17004 a rdfs:Class ;
rdfs:label "Genetic Polymorphism" ;
rdfs:comment "The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site to large nucleotide sequences visible at a chromosomal level." ;
rdfs:subClassOf obo:SCDO_0001369 .
obo:HP_0011675 a rdfs:Class ;
rdfs:label "Arrhythmia" ;
rdfs:comment "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_0000133 a rdfs:Class ;
rdfs:label "Blood Test" ;
rdfs:comment "Test used in the analysis of the hemic system." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_0000593 a rdfs:Class ;
rdfs:label "Hyperpigmentation" ;
rdfs:comment "Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance." ;
rdfs:subClassOf obo:HP_0011121 .
obo:SCDO_1000699 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin A2 Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A2." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000008 a rdfs:Class ;
rdfs:label "deprecated Abnormality of Erythrocytes" ;
rdfs:comment "Abnormality in structure and function of the Red Blood Cell." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000993 a rdfs:Class ;
rdfs:label "Respiratory Rate" ;
rdfs:comment "The number of times an organism breathes with the lungs (respiration) per unit time, usually per minute." ;
rdfs:subClassOf obo:CMO_0000094 .
obo:SCDO_1000685 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Reticulocyte Count Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the reticulocyte count in the respondent's blood, as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001247 a rdfs:Class ;
rdfs:label "World Health Organisation Quality of Life Instrument (WHOQOL)" ;
rdfs:comment "The WHOQOL is a quality of life assessment developed by the WHOQOL Group with fifteen international field centres, simultaneously, in an attempt to develop a quality of life assessment that would be applicable cross-culturally." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:NCIT_C67251 a rdfs:Class ;
rdfs:label "million cells per microliter" ;
rdfs:comment "A unit of cell concentration expressed as a number of cells in millions per unit volume equal to one microliter." ;
rdfs:subClassOf obo:UO_0000316 .
obo:NCIT_C154865 a rdfs:Class ;
rdfs:label "Cerebral Blood Flow Assay" ;
rdfs:comment "An evaluation of the perfusion of blood through the brain." ;
rdfs:subClassOf obo:SCDO_0000208 , obo:SCDO_1000316 .
obo:SCDO_1000476 a rdfs:Class .
obo:SCDO_1000740 a rdf:Property ;
rdfs:label "has sections" ;
rdfs:comment "Used to provide a list of sections present in a questionnaire/instrument." ;
rdfs:domain obo:SCDO_1000476 ;
rdfs:range xsd:string .
obo:NCIT_C16612 a rdfs:Class ;
rdfs:label "Gene" ;
rdfs:comment "A functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function." ;
rdfs:subClassOf obo:SCDO_0005722 .
obo:HP_0002086 a rdfs:Class ;
rdfs:label "Abnormality of the Respiratory System" ;
rdfs:comment "An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles." ;
rdfs:subClassOf obo:HP_0000118 .
obo:HP_0001343 a rdfs:Class ;
rdfs:label "Kernicterus" ;
rdfs:comment "Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_0004078 a rdfs:Class ;
rdfs:label "Girdle Syndrome" ;
rdfs:comment "Characterized by an established ileus, with vomiting, a silent distended abdomen and distended bowel loops and fluid levels on abdominal x-ray. Some hepatic enlargement is common, and it is often associated with bilateral basal lung consolidation (chest syndrome)." ;
rdfs:subClassOf obo:HP_0000118 .
obo:NCIT_C25298 a rdfs:Class ;
rdfs:label "Systolic Blood Pressure" ;
rdfs:comment "The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart." ;
rdfs:subClassOf obo:CMO_0000003 .
obo:CMO_0000036 a rdfs:Class ;
rdfs:label "Blood Cell Measurement" ;
rdfs:comment "A value resulting from the quantification of a morphological or physiological parameter of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning." ;
rdfs:subClassOf obo:CMO_0000035 .
obo:CMO_0000025 a rdfs:Class ;
rdfs:label "Red Blood Cell Count" ;
rdfs:comment "The number of red blood cells in a specified volume of blood most commonly 1 cubic millimeter (i.e. 1 microliter) of peripheral venous blood." ;
rdfs:subClassOf obo:CMO_0001356 .
obo:SCDO_0000762 a rdfs:Class ;
rdfs:label "Mobile Radiographic Unit" ;
rdfs:comment "Transportable radiographic equipment allowing imaging services to be brought to the patient." ;
rdfs:subClassOf obo:OBI_0001138 .
obo:SCDO_1000191 a rdf:Property ;
rdfs:label "used by diagnostic tool" ;
rdfs:comment "A relationship between a diagnostic device and the diagnostic tool by which the device is used." ;
rdfs:range .
obo:NCIT_C3245 a rdfs:Class ;
rdfs:label "Fungal Infection" ;
rdfs:comment "An infection caused by a fungus." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:SCDO_1000472 a rdfs:Class ;
rdfs:label "Data Standards" ;
rdfs:comment "The rules by which data are described and recorded." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_1000383 a rdfs:Class ;
rdfs:label "Renal Complication" ;
rdfs:comment "Any kidney disorder occurring as a consequence of injury to the kidney." ;
rdfs:subClassOf obo:NCIT_C2959 .
obo:SCDO_0000923 a rdfs:Class ;
rdfs:label "Priapism" ;
rdfs:comment "A prolonged painful erection that may last hours and is not associated with sexual activity. It is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma, and certain drug treatments." ;
rdfs:subClassOf obo:HP_0000080 , obo:SCDO_0000016 , obo:SCDO_0000954 .
obo:SCDO_0000571 a rdfs:Class ;
rdfs:label "HIV Test" ;
rdfs:comment "A bioassay to measure human immunodeficiency virus (HIV) antibodies and/or HIV antigens in order to determine whether an individual has an HIV infection." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:NCIT_C118385 a rdfs:Class ;
rdfs:label "deprecated-Avascular Necrosis" ;
rdfs:comment "Tissue death resulting from an interruption to the blood supply." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000947 a rdfs:Class ;
rdfs:label "Quality of Care Measure" ;
rdfs:comment "The systemic measurement of the quality of health care that includes a broad set of perfomance measures such as the quality of services and the outcomes analysis for particular diseases and conditions, mortality and morbidity, patient safety, data on maternal and child health, as well as evaluation of quality of diagnosis, care accessibility, implementation of proven evidence-based practices, quality of reporting systems for errors and adverse events, reliability and accessibility of health and health care-related information, and health care organizations infrastructure." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:HP_0001903 a rdfs:Class ;
rdfs:label "Anemia" ;
rdfs:comment "A reduction in erythrocytes volume or hemoglobin concentration." ;
rdfs:subClassOf obo:HP_0001877 .
obo:SCDO_0000283 a rdfs:Class ;
rdfs:label "obsolete Controlled Clinical Trial" ;
rdfs:comment "'A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterized as a randomized controlled trial. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000254 .
obo:HP_0001977 a rdfs:Class ;
rdfs:label "Abnormal Thrombosis" ;
rdfs:comment "Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis)." ;
rdfs:subClassOf obo:HP_0001871 .
obo:SCDO_0004187 a rdfs:Class ;
rdfs:label "Hemolytic Crisis" ;
rdfs:comment "May be caused by an acute VOC, malarial infection or oxidant drug exposure in individuals with concomitant glucose-6-phosphate dehydrogenase (G6PD) deficiency. Haemolytic crisis may be distinguished from aplastic crisis by the finding of a reticulocytosis as opposed to a reticulocytopenia." ;
rdfs:subClassOf obo:HP_0001871 .
obo:SCDO_1000554 a rdfs:Class ;
rdfs:label "Date of Diagnosis Known" ;
rdfs:comment "An indication of whether the date of the respondent's diagnosis of a disease is known by the respondent or the respondent's guardian." ;
rdfs:subClassOf obo:SCDO_1000538 .
obo:SCDO_1000305 a rdfs:Class ;
rdfs:label "Pulse Oximetry (Exercise)" ;
rdfs:comment "Exercise testing for evaluation of hypoxemia and/or desaturation that occurs on exertion." ;
rdfs:subClassOf obo:NCIT_C38085 .
obo:SCDO_0000698 a rdfs:Class ;
rdfs:label "Locus of Control" ;
rdfs:comment "Personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behaviour versus fate, luck, or external forces." ;
rdfs:subClassOf obo:SCDO_0000488 .
obo:HP_0000834 a rdfs:Class ;
rdfs:label "Abnormality of the Adrenal Glands" ;
rdfs:comment "Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kidneys." ;
rdfs:subClassOf obo:HP_0000818 .
obo:SCDO_0000407 a rdfs:Class ;
rdfs:label "Ecchymosis" ;
rdfs:comment "A small hemorrhagic spot, larger than a petechia, in the skin or mucous membrane forming a nonelevated, rounded or irregular, blue or purplish patch." ;
rdfs:subClassOf obo:HP_0002597 .
obo:SCDO_0000034 a rdfs:Class ;
rdfs:label "Alanine Aminotransferase Blood Test" ;
rdfs:comment "A quantitative measurement of alanine aminotransferase present in a blood sample." ;
rdfs:subClassOf obo:NCIT_C74954 , obo:SCDO_0000133 .
obo:SCDO_1000489 a rdfs:Class ;
rdfs:label "deprecated Slider - Visual Analog Scale" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:SCDO_0002107 a rdfs:Class ;
rdfs:label "deprecated-Nature of Mutations" ;
rdfs:comment "This represents the phenotypic feature of mutational effects on a given property of an organism biological system [Gaston K. Mazandu, []]." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000934 a rdfs:Class ;
rdfs:label "Provider Attitudes Toward Patients with Sickle Cell Disease" ;
rdfs:comment "This is a 17-item scale, separated into 4 subscales with good psychometric properties. Negative Attitudes Scale comprises six items grouped together (Mean=36.5, SD=21.9, Potential range = 0 to 100). Higher scores on this scale indicate an endorsement of more negative views about SCD patients. Positive Attitudes Scale comprises four items grouped together (Mean=45.7, SD=24.3, Potential range = 0 to 100). Higher scores indicate an endorsement of more positive views about SCD patients. Concern Raising Behaviors Scale comprises four items grouped together (Mean = 53.7, SD = 22.0, Potential range = 0 to 100). Higher scores indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern that the patient is inappropriately drug-seeking. Red-Flag Behaviors Scale comprises three items grouped together (Mean = 58.7, SD = 22.7, Potential range = 0 to 100). Higher scores on this scale indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern about patient drug-seeking." ;
rdfs:subClassOf obo:SCDO_0000947 .
obo:HP_0003110 a rdfs:Class ;
rdfs:label "Abnormal Urine Homeostasis" ;
rdfs:comment "An abnormality of the composition of urine or the levels of its components." ;
rdfs:subClassOf obo:HP_0000079 , obo:SCDO_0002674 .
obo:SCDO_0000955 a rdfs:Class ;
rdfs:label "Quality-Adjusted Life Year (QALY)" ;
rdfs:comment "QALYs are used primarily to correct a person's life expectancy based on the levels of health-related quality of life they are predicted to experience throughout the course of their life, or part of it." ;
rdfs:subClassOf obo:SCDO_0000495 , obo:SCDO_0000951 .
obo:SCDO_0000082 a rdfs:Class ;
rdfs:label "Diagnostic Technique, Method, Test or Assay" ;
rdfs:comment "A planned process with the objective of producing diagnostic information about the material entity that is the evaluant, by physically examining it or its proxies." ;
rdfs:subClassOf obo:SCDO_1000032 .
obo:SCDO_1000041 a rdfs:Class ;
rdfs:label "HBB, GLU6LYS" ;
rdfs:comment "A mutation where the glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation results in the production of Hemoglobin C and confers resistance to malaria." ;
rdfs:subClassOf obo:SCDO_0009786 .
obo:SCDO_0000067 a rdfs:Class ;
rdfs:label "Antihypertensive Agents" ;
rdfs:comment "Used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. Among the antihypertensive agents are diuretics; (especially diuretics, thiazide); adrenergic aeta-antagonists; adrenergic alpha-antagonistics; angiotensin-converting enzyme inhibitors; calcium channel blockers; ganglionic blockers; and vasodilator agents." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001129 .
obo:SCDO_0300005 a rdfs:Class ;
rdfs:label "Research Characteristics" ;
rdfs:comment "Elements, types, descriptions and formulations of a research study." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:SCDO_0001064 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S/O-Arab" ;
rdfs:comment "One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin O-Arab. It can cause anemia, repeated infections, and periodic episodes of pain and organ damage." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000163 .
obo:NCIT_C133543 a rdfs:Class ;
rdfs:label "Crizanlizumab" ;
rdfs:comment "A humanized monoclonal immunoglobulin G1 anti-P-selectin antibody with vaso-protective and anti-vaso-occlusive properties. Upon administration, crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand-1 (PSGL-1; SELPLG) on neutrophils and monocytes. P-selectin, a glycoprotein that functions as a cell adhesion molecule (CAM), translocates to the surface of activated endothelial cells and platelets, upon stimulation, where it binds to its ligand and mediates the rolling of platelets and neutrophils on activated endothelial cells. Therefore, blockade of p-selectin may inhibit platelet aggregation, maintain blood flow and minimize sickle cell-related pain crises (SCPC)." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0000922 .
obo:SCDO_1000806 a rdfs:Class ;
rdfs:label "Absent Hemoglobin C" ;
rdfs:comment "A lack of production of hemoglobin C." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_0000234 a rdfs:Class ;
rdfs:label "Chronic Sickle Cell Pain Management" ;
rdfs:comment "Sickle cell pain management that aims to restore function and improve the quality of life." ;
rdfs:subClassOf obo:SCDO_0001052 .
obo:SCDO_0000541 a rdfs:Class ;
rdfs:label "Hemoglobin M Disease" ;
rdfs:comment "A type of dominant hereditary methemoglobinemia resulting from the production of hemoglobin M, which is readily oxidised to yield excess methemoglobin which leads to cyanosis." ;
rdfs:subClassOf obo:SCDO_0000559 , obo:SCDO_0008262 .
obo:SCDO_0009620 a rdfs:Class ;
rdfs:label "deprecated Low Reticulocyte Count" ;
rdfs:comment "An abnormally low number of reticulocytes per unit volume of blood." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:CMO_0000001 a rdfs:Class ;
rdfs:label "Cardiovascular Measurement" ;
rdfs:comment "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_0000418 a rdfs:Class ;
rdfs:label "Electroencephalogram" ;
rdfs:comment "A graphic record of the electrical activity of the brain as recorded by an electroencephalograph." ;
rdfs:subClassOf obo:SCDO_1000313 .
obo:HP_0011950 a rdfs:Class ;
rdfs:label "Bronchiolitis" ;
rdfs:comment "Inflammation of the bronchioles." ;
rdfs:subClassOf obo:HP_0002086 .
obo:HP_0000079 a rdfs:Class ;
rdfs:label "Abnormality of the Urinary System" ;
rdfs:comment "An abnormality of the urinary system." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0001053 a rdfs:Class ;
rdfs:label "Sickle Cell Painful Event" ;
rdfs:comment "Pain lasting at least two hours that requires an unscheduled emergency room visit or hospitalization or that disrupts daily activities." ;
rdfs:subClassOf obo:SCDO_0001023 .
obo:NCIT_C120256 a rdfs:Class ;
rdfs:label "Intelligence Scale - 2 years, 6 months to 7 years, 7 months" ;
rdfs:comment "A standardized tool designed to assess the cognitive development in preschool and young children (up to age 7 years and 7 months). It consists of a battery of tests that allow an investigator to conduct a comprehensive evaluation of IQ." ;
rdfs:subClassOf obo:NCIT_C122920 .
obo:SCDO_1000891 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Diastolic Blood Pressure Question" ;
rdfs:comment "The Sickle in Africa core data element that records a participant's diastolic blood pressure." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:OPMI_0000027 a rdfs:Class ;
rdfs:label "Refused" ;
rdfs:comment "An answer to question where one declines to answer the specified question." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_0000498 a rdfs:Class ;
rdfs:label "Healthy Lifestyle" ;
rdfs:comment "A pattern of behavior involving lifestyle choices which ensure optimum health. Examples are eating right; maintaining physical, emotional, and spiritual wellness, and taking preemptive steps against communicable diseases." ;
rdfs:subClassOf obo:SCDO_0000689 .
obo:SCDO_0000088 a rdfs:Class ;
rdfs:label "Atopic Dermatitis" ;
rdfs:comment "A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema." ;
rdfs:subClassOf obo:HP_0011123 .
obo:APOLLO_SV_00000241 a rdfs:Class ;
rdfs:label "Age Range Category" ;
rdfs:comment "An information content entity specifying the upper and lower limit of a range of ages of continuants." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0005593 a rdfs:Class ;
rdfs:label "Genetic Code" ;
rdfs:comment "The meaning ascribed to the base sequence with respect to how it is translated into amino acid sequence. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons." ;
rdfs:subClassOf obo:SCDO_0005722 .
obo:SCDO_0000122 a rdfs:Class ;
rdfs:label "Biological Disease Modifier" ;
rdfs:comment "A biological factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease." ;
rdfs:subClassOf obo:SCDO_0000391 .
obo:HP_0000824 a rdfs:Class ;
rdfs:label "Growth Hormone Deficiency" ;
rdfs:comment "Insufficient production of growth hormone, which is produced by the anterior pituitary gland. Growth hormone is a major participant in control of growth and metabolism." ;
rdfs:subClassOf obo:HP_0000818 .
obo:HP_0012594 a rdfs:Class ;
rdfs:label "Low Level Albuminuria" ;
rdfs:comment "The presence of mildly increased concentrations of albumin in the urine (in adults, 30-150 mg per day)." ;
rdfs:subClassOf obo:SCDO_0000037 .
obo:SCDO_1000233 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype M" ;
rdfs:comment "The presence of an amino acid substitution in either an alpha-, beta-, or gamma-globin chain such that its proximity to the heme iron in the hemoglobin molecule results in facilitated oxidation of the hemoglobin to yield excess methemoglobin. This can occur in either one or both alleles of the effected gene." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:NCIT_C164339 a rdfs:Class ;
rdfs:label "Date of Diagnosis" ;
rdfs:comment "The date on which a diagnosis of disease was made." ;
rdfs:subClassOf obo:SCDO_1000538 .
obo:SCDO_1000342 a rdfs:Class ;
rdfs:label "History of Transfusion Diagnostic Instrument" ;
rdfs:comment "A questionnaire to assess history of transfusion." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_0001204 a rdfs:Class ;
rdfs:label "Urban Location" ;
rdfs:comment "The region surrounding a city. Most inhabitants of urban areas have nonagricultural jobs. Urban areas are very developed, meaning there is a density of human structures such as houses, commercial buildings, roads, bridges, and railways." ;
rdfs:subClassOf obo:GAZ_00000448 , obo:SCDO_0000496 .
obo:SCDO_0010000 a rdfs:Class ;
rdfs:label "obsolete Other Genotypes" ;
rdfs:comment "'Genotypes which are not specific to sickle cell trait.'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000128 a rdfs:Class ;
rdfs:label "Luo" ;
rdfs:comment "Luo, also called Joluo or Kavirondo constitute the fourth largest ethnic group in Kenya. The Luo speak a Nilotic language of the Nilo-Saharan language family." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000402 a rdfs:Class ;
rdfs:label "Drug-Induced Neuropathy AE" ;
rdfs:comment "A neuropathy AE that is induced by a drug administration." ;
rdfs:subClassOf obo:SCDO_0000191 .
obo:SCDO_0000650 a rdfs:Class ;
rdfs:label "Intentional Drug Misuse AE" ;
rdfs:comment "An adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc)." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:SCDO_0000881 a rdfs:Class ;
rdfs:label "Penicillin Prophylaxis" ;
rdfs:comment "Use of penicillin for the prevention of infections with penicillin-susceptible organisms, e.g. Streptococcus pneumoniae." ;
rdfs:subClassOf obo:NCIT_C51993 .
obo:SCDO_1000880 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Relationship to Participant Question" ;
rdfs:comment "The Sickle in Africa core data element that records the participant's next of kin's relationship to the participant." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000156 a rdfs:Class ;
rdfs:label "Brachial Artery Ultrasound Imaging" ;
rdfs:comment "A noninvasive method to assess the endothelial dysfunction in the brachial artery." ;
rdfs:subClassOf obo:NCIT_C17230 , obo:SCDO_0001228 .
obo:SCDO_0001292 a rdfs:Class ;
rdfs:label "D57.00 Hb-SS disease with crisis, unspecified" ;
rdfs:comment "Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis." ;
rdfs:subClassOf obo:SCDO_0000312 .
obo:SCDO_0000988 a rdfs:Class ;
rdfs:label "deprecated Reproductive System" ;
rdfs:comment "'Anatomical system that has as its parts the organs concerned with reproduction. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0003894 a rdfs:Class ;
rdfs:label "Gap PCR" ;
rdfs:comment "The polymerase chain reaction (PCR) is the most common method to detect the deletional thalassaemias. Gap-PCR amplifies the deleted DNA sequence using the primers flanking the deleted region 10. Three primers are designed for each deletion to amplify the normal (undeleted) and deleted gene sequences." ;
rdfs:subClassOf obo:SCDO_0000913 .
obo:SCDO_0000116 a rdfs:Class ;
rdfs:label "Beta-Globin Locus" ;
rdfs:comment "A globin locus composed of five genes located on a short 45 kb region of chromosome 11. The order of genes in this cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. It is responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin." ;
rdfs:subClassOf obo:SCDO_0000456 .
obo:SCDO_0001284 a rdfs:Class ;
rdfs:label "Behaviour Therapy" ;
rdfs:comment "The application of modern theories of learning and conditioning in the treatment of behavior disorders." ;
rdfs:subClassOf obo:SCDO_0000940 .
obo:HP_0002907 a rdfs:Class ;
rdfs:label "Microscopic Hematuria" ;
rdfs:comment "Microscopic hematuria detected by dipstick or microscopic examination of the urine." ;
rdfs:subClassOf obo:SCDO_0000508 .
obo:SCDO_0000183 a rdfs:Class ;
rdfs:label "Cardioscope" ;
rdfs:comment "An instrument which, by means of a cathode-ray oscillograph, projects an electrocardiographic record on a luminous screen." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_1000153 a rdfs:Class ;
rdfs:label "Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives" ;
rdfs:comment "A review of service delivery across Europe to children with sickle cell disease (SCD), reporting on the available minimum standards of care and future perspectives." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_1000179 a rdfs:Class ;
rdfs:label "Absent Hemoglobin E" ;
rdfs:comment "A lack of production of hemoglobin E." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_0005671 a rdfs:Class ;
rdfs:label "HBB and HBD Deletion" ;
rdfs:comment "Deletion of the HBB and HBD genes that results in delta-beta thalassemia." ;
rdfs:subClassOf obo:SCDO_0004905 , obo:SCDO_1000366 .
obo:HP_0004364 a rdfs:Class ;
rdfs:label "Abnormal Circulating Nitrogen Compound Concentration" ;
rdfs:comment "Any deviation from the normal concentration of a nitrogen compound in the blood circulation." ;
rdfs:subClassOf obo:HP_0032180 .
obo:HP_0025066 a rdfs:Class ;
rdfs:label "Decreased Mean Corpuscular Volume" ;
rdfs:comment "A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters)." ;
rdfs:subClassOf obo:HP_0025065 .
obo:SCDO_0001295 a rdfs:Class ;
rdfs:label "Electrocardiograph" ;
rdfs:comment "An instrument used in the detection and diagnosis of heart abnormalities that measures electrical potentials on the body surface and generates a record of the electrical currents associated with heart muscle activity." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_0000265 a rdfs:Class ;
rdfs:label "Coma" ;
rdfs:comment "A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem reticular formation." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_1000119 a rdfs:Class ;
rdfs:label "Fon" ;
rdfs:comment "The largest ethnic group in Benin is Fon/Dahomey which constitutes 39% of the total population. Established in 1600 by the Fon, a group that came about through the intermarriage between the Adja and local Gedevi." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000694 a rdfs:Class ;
rdfs:label "Liver Examination" ;
rdfs:comment "Any process carried out to determine the condition of a patient's liver." ;
rdfs:subClassOf obo:SCDO_0000898 .
obo:NCIT_C103270 a rdfs:Class ;
rdfs:label "Waiver of Consent" ;
rdfs:comment "The release from the requirement to obtain informed consent during a study that is granted by Human Subject Protection committee for a research institution for a protocol that is being reviewed by the Institutional Review Board." ;
rdfs:subClassOf obo:SCDO_1000462 .
obo:NCIT_C98835 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S Beta Zero Thalassemia" ;
rdfs:comment "A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease." ;
rdfs:subClassOf obo:NCIT_C95539 .
obo:SCDO_0000149 a rdfs:Class ;
rdfs:label "Body Height" ;
rdfs:comment "The distance from the sole to the crown of the head with body standing on a flat surface and fully extended." ;
rdfs:subClassOf obo:CMO_0000011 .
obo:HP_0011106 a rdfs:Class ;
rdfs:label "Hypovolemia" ;
rdfs:comment "A decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_1000838 a rdfs:Class ;
rdfs:label "Normal Partial Pressure of Oxygen" ;
rdfs:comment "When the pressure exerted by oxygen dissolved in the blood falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:HP_0002071 a rdfs:Class ;
rdfs:label "Extrapyramidal Symptoms" ;
rdfs:comment "A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless)." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_1000495 a rdfs:Class ;
rdfs:label "Multiple Choice Multiple Selection Question" ;
rdfs:comment "A close-ended question that provides multiple answers for respondents to select from and allows for the selection of multiple options." ;
rdfs:subClassOf obo:SCDO_1000492 .
obo:SCDO_0000514 a rdfs:Class ;
rdfs:label "Hemoglobin S" ;
rdfs:comment "An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_0003807 .
obo:SCDO_1000208 a rdfs:Class ;
rdfs:label "Genetic Crossing Over" ;
rdfs:comment "The reciprocal exchange of segments at corresponding positions along pairs of homologous chromosomes by symmetrical breakage and crosswise rejoining forming cross-over sites (Holliday junctions) that are resolved during chromosome segregation. Crossing-over typically occurs during meiosis but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes." ;
rdfs:subClassOf obo:SCDO_1000207 .
obo:SCDO_1000579 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Blood Group Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's ABO Blood Group." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0003641 a rdfs:Class ;
rdfs:label "Hemoglobinuria" ;
rdfs:comment "The presence of free hemoglobin in the urine." ;
rdfs:subClassOf obo:HP_0000077 , obo:SCDO_1000383 .
obo:SCDO_0000740 a rdfs:Class ;
rdfs:label "Medication Inventory" ;
rdfs:comment "A record of the type and dosage of all prescription and over-the-counter medications as well as dietary supplements currently being taken by the individual." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_1000157 .
obo:NCIT_C86008 a rdfs:Class ;
rdfs:label "Methemoglobin" ;
rdfs:comment "A product of hemoglobin produced by oxidation of the iron atom from the ferrous to the ferric state." ;
rdfs:subClassOf obo:NCIT_C16676 .
obo:HP_0002427 a rdfs:Class ;
rdfs:label "Motor Aphasia" ;
rdfs:comment "Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0002125 a rdfs:Class ;
rdfs:label "Confidentiality" ;
rdfs:comment "The privacy of information and its protection against unauthorized disclosure." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0001851 a rdfs:Class ;
rdfs:label "Tachycardia" ;
rdfs:comment "A rapid heartrate that exceeds the range of the normal resting heartrate for age, gender or patient population." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_0000276 a rdfs:Class ;
rdfs:label "Conjunctival Comma Sign" ;
rdfs:comment "Dark red, comma- or corkscrew-shaped vascular fragment that appears to be isolated from neighboring blood vessels in the conjunctiva. Normally benign, this lesion can serve as the first diagnostic sign of sickle cell retinopathy. The conjunctival comma sign results from transient vaso-occlusive processes in the microvasculature of bulbar conjunctiva. It is not seen in sickle trait, but is common in SCD." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:SCDO_1000796 a rdfs:Class ;
rdfs:label "D57.439 Sickle-cell thalassemia beta zero with crisis, unspecified" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000791 .
obo:SCDO_1000052 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype SE" ;
rdfs:comment "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin E (HBB Glu26Lys) variants." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:SCDO_1000714 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Respiratory Rate Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's respiratory rate." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000742 a rdfs:Class ;
rdfs:label "Mefloquine" ;
rdfs:comment "A phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects." ;
rdfs:subClassOf obo:IDOMAL_0000122 .
obo:SCDO_0001237 a rdfs:Class ;
rdfs:label "Vitrectomy" ;
rdfs:comment "Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma." ;
rdfs:subClassOf obo:SCDO_0000833 .
obo:HP_0000478 a rdfs:Class ;
rdfs:label "Abnormality of the Eye" ;
rdfs:comment "Any abnormality of the eye, including location, spacing, and intraocular abnormalities." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0001304 a rdfs:Class ;
rdfs:label "Executive Function Measure" ;
rdfs:comment "An interviewer-administered test to measure a respondent's system of high-level cognitive functions such as abstract thinking, rule acquisition, cognitive flexibility, and goal-oriented behavior." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_1000516 a rdfs:Class ;
rdfs:label "Genetic Material Storage Consent" ;
rdfs:comment "Voluntary authorization given by a study paticipant to have their genetic material stored." ;
rdfs:subClassOf obo:SCDO_0007087 .
obo:SCDO_0000738 a rdfs:Class ;
rdfs:label "Medical Records" ;
rdfs:comment "Recording of pertinent information concerning patient's illness or illnesses." ;
rdfs:subClassOf obo:SCDO_0000948 .
obo:SCDO_1000421 a rdfs:Class ;
rdfs:label "Participant Feedback Policy" ;
rdfs:comment "The standard method of providing feedback to study participants regarding their information (data, biological samples, genetic material) that has been shared." ;
rdfs:subClassOf obo:SCDO_1000422 , obo:SCDO_1000424 .
obo:HP_0020054 a rdfs:Class ;
rdfs:label "Abnormal Erythrocyte Physiology" ;
rdfs:comment "Any functional abnormality of erythrocytes (red-blood cells)." ;
rdfs:subClassOf obo:HP_0001871 .
obo:HP_0001999 a rdfs:Class ;
rdfs:label "Facial Dysmorphisms" ;
rdfs:comment "An abnormal morphology (form) of the face or its components." ;
rdfs:subClassOf obo:HP_0000271 .
obo:SCDO_0001151 a rdfs:Class ;
rdfs:label "Therapeutic Irrigation" ;
rdfs:comment "The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis." ;
rdfs:subClassOf obo:SCDO_0001129 .
obo:HP_0030049 a rdfs:Class ;
rdfs:label "Brain Abscess" ;
rdfs:comment "A collection of pus, immune cells, and other material in the brain." ;
rdfs:subClassOf obo:HP_0002715 , obo:HP_0012639 .
obo:SCDO_0000193 a rdfs:Class ;
rdfs:label "Causal Adverse Drug Event Due to Food-Drug Interaction" ;
rdfs:comment "A causal adverse drug event that is induced by a food-drug interaction." ;
rdfs:subClassOf obo:SCDO_0000191 .
obo:SCDO_1000584 a rdfs:Class ;
rdfs:label "Blood Type B Positive" ;
rdfs:comment "A blood type containing type B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." ;
rdfs:subClassOf obo:HP_0032224 .
obo:SCDO_0003807 a rdfs:Class ;
rdfs:label "Abnormal Hemoglobin" ;
rdfs:comment "Hemoglobin characterized by structural alterations within the molecule that confer an inherited health condition phenotype. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains." ;
rdfs:subClassOf obo:HP_0001877 , obo:SCDO_0006921 .
obo:SCDO_0000347 a rdfs:Class ;
rdfs:label "deprecated Dental System" ;
rdfs:comment "'The system pertaining to teeth, oral cavity, and associated structures. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000856 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - First Name Question" ;
rdfs:comment "The Sickle in Africa core data element that records a respondent's first name." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:NCIT_C115199 a rdfs:Class ;
rdfs:label "Cardiovascular Complication" ;
rdfs:comment "Any heart or vascular disorder occurring as a consequence of injury to the cardiovascular system." ;
rdfs:subClassOf obo:NCIT_C2959 .
obo:SCDO_1000793 a rdfs:Class ;
rdfs:label "D57.432 Sickle-cell thalassemia beta zero with splenic sequestration" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000791 .
obo:SCDO_1000669 a rdfs:Class ;
rdfs:label "Sickle SCAN Rapid Test" ;
rdfs:comment "A multiplexed qualitative point-of-care immunoassay used for the rapid diagnosis of sickle cell disorders. The test is made up of three indicators which detect the presence of hemoglobins A, S, and C, allowing the user to rapidly distinguish between normal, carrier, and sickle cell samples." ;
rdfs:subClassOf obo:SCDO_0000522 , obo:SCDO_1000577 .
obo:HP_0007902 a rdfs:Class ;
rdfs:label "Vitreous Hemorrhage" ;
rdfs:comment "Bleeding within the vitreous compartment of the eye." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:NCIT_C142541 a rdfs:Class ;
rdfs:label "Research Ethics Committee" ;
rdfs:comment "An independent group that comprises medical, scientific, and non-scientific members, and is tasked with the continuing review and approval of research, including clinical trials, with respect to the protocols, methods, and informed consent process to ensure the protection of the rights, safety, and wellbeing of participants." ;
rdfs:subClassOf obo:SCDO_1000430 .
obo:SCDO_1000063 a rdfs:Class ;
rdfs:label "HBB, 106-KB DEL" ;
rdfs:comment "A 106-kb deletion of the beta globin gene cluster." ;
rdfs:subClassOf obo:SCDO_0004905 , obo:SCDO_0009786 .
obo:SCDO_0001624 a rdfs:Class ;
rdfs:label "Non-Anemic" ;
rdfs:comment "Not anemic, i.e. no reduction in erythrocytes volume and/or hemoglobin concentration." ;
rdfs:subClassOf obo:NCIT_C3833 .
obo:SCDO_0001322 a rdfs:Class ;
rdfs:label "Serum Ferritin Test" ;
rdfs:comment "A bioassay to measure the serum concentration of ferritin (i.e., iron)." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_0000809 a rdfs:Class ;
rdfs:label "Non Opioid" ;
rdfs:comment "A subclass of analgesic agents that typically do not bind to opioid receptors and are not addictive. Many non-narcotic analgesics are offered as nonprescription drugs." ;
rdfs:subClassOf obo:SCDO_0000050 .
obo:NCIT_C64783 a rdfs:Class ;
rdfs:label "g/dL" ;
rdfs:comment "A unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one deciliter (100 milliliters). The concept also refers to the metric unit of mass density (volumic mass) defined as the density of substance which mass equal to one gram occupies the volume one deciliter." ;
rdfs:subClassOf obo:UO_0000180 .
obo:SCDO_0000189 a rdfs:Class ;
rdfs:label "Case-Control Studies" ;
rdfs:comment "Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_1000551 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Sex Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's sex." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000098 a rdfs:Class ;
rdfs:label "Case Report Form (CRF)" ;
rdfs:comment "A paper or electronic questionnaire specifically used in research by the sponsor of the research to collect data from each research participant. All data on each participant in the study are held and/or documented in the CRF, including adverse events." ;
rdfs:subClassOf obo:SCDO_0300003 .
obo:SCDO_0001213 a rdfs:Class ;
rdfs:label "Urine Creatinine Concentration" ;
rdfs:comment "The concentration of creatinine in a urine specimen." ;
rdfs:subClassOf obo:CMO_0000256 .
obo:HP_0001640 a rdfs:Class ;
rdfs:label "Cardiomegaly" ;
rdfs:comment "Increased size of the heart." ;
rdfs:subClassOf obo:HP_0030680 .
obo:SCDO_1000432 a rdfs:Class ;
rdfs:label "Serum iFABP Level" ;
rdfs:comment "The level of intestinal fatty-acid binding protein in the systemic circulation (serum)." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_0000314 a rdfs:Class ;
rdfs:label "D57.02 Hb-SS disease with splenic sequestration" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000312 .
obo:HP_0025435 a rdfs:Class ;
rdfs:label "Increased Lactate Dehydrogenase Level" ;
rdfs:comment "An elevated level of the enzyme lactate dehydrogenase in serum." ;
rdfs:subClassOf obo:HP_0045040 .
obo:SCDO_1000878 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Next of Kin Name Question" ;
rdfs:comment "The Sickle in Africa core data element that records the name of the participant's next of kin." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0003155 a rdfs:Class ;
rdfs:label "Elevated Serum Alkaline Phosphatase" ;
rdfs:comment "Abnormally increased serum levels of alkaline phosphatase activity." ;
rdfs:subClassOf obo:HP_0004379 .
obo:SCDO_0000440 a rdfs:Class ;
rdfs:label "Epilepsy Screener" ;
rdfs:comment "A questionnaire to assess epilepsy, a condition characterized by recurrent seizures and which is a component of over 40 neurological disorders (Aminoff, et al., 2005)." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:ARO_0000006 a rdfs:Class ;
rdfs:label "Erythromycin" ;
rdfs:comment "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited." ;
rdfs:subClassOf obo:NCIT_C258 , obo:SCDO_0000922 .
obo:SCDO_1000722 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Partial Pressure O2 Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's partial pressure of oxygen their arterial blood, as measured by an arterial blood gas test." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000088 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/S-South End" ;
rdfs:comment "A compound heterozygous genotype, involving the mutations for hemoglobin S and hemoglobin S-South End." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:NCIT_C71746 a rdfs:Class ;
rdfs:label "Vascular Access Device Complications" ;
rdfs:comment "Difficulties related to an apparatus used to gain access to arteries and veins." ;
rdfs:subClassOf obo:NCIT_C78254 .
obo:SCDO_1000774 a rdfs:Class ;
rdfs:label "D57.03 Hb-SS disease with cerebral vascular involvement" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000312 .
obo:SCDO_1000281 a rdfs:Class ;
rdfs:label "Secondary Hemochromatosis" ;
rdfs:comment "An acquired metabolic disorder characterized by iron accumulation in the tissues." ;
rdfs:subClassOf obo:NCIT_C78393 .
obo:SCDO_1000236 a rdfs:Class ;
rdfs:label "Hemoglobin Lepore Boston Genotype" ;
rdfs:comment "The homozygous genotype for Hemoglobin Lepore Boston that involves a crossover between both sets of delta (HBD) and beta globin (HBB) gene loci during meiosis." ;
rdfs:subClassOf obo:SCDO_0007624 .
obo:HP_0001392 a rdfs:Class ;
rdfs:label "Abnormality of the Liver" ;
rdfs:comment "An abnormality of the liver." ;
rdfs:subClassOf obo:HP_0025031 .
obo:SCDO_0000942 a rdfs:Class ;
rdfs:label "Pulmonary Function Test" ;
rdfs:comment "Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:OBI_0001098 a rdfs:Class ;
rdfs:label "Ultrasound Machine" ;
rdfs:comment "A device that is used to visualize subcutaneous body structures including tendons, muscles, joints, vessels and internal organs." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:HP_0012532 a rdfs:Class ;
rdfs:label "Chronic Pain" ;
rdfs:comment "Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months." ;
rdfs:subClassOf obo:SCDO_0000851 , obo:SCDO_0001334 .
obo:SCDO_1000158 a rdfs:Class ;
rdfs:label "Crystallised Hemoglobin" ;
rdfs:comment "Hemoglobin that has undergone conformational changes resulting in increased hydrophobicity that results in the formation of solid crystals consisting of hemoglobin particles." ;
rdfs:subClassOf obo:SCDO_0003807 .
obo:OBI_0200198 a rdfs:Class ;
rdfs:label "Tandem Mass Spectrometry" ;
rdfs:comment "A data transformation that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules)." ;
rdfs:subClassOf obo:SCDO_0000216 .
obo:SCDO_0001224 a rdfs:Class ;
rdfs:label "Vaping" ;
rdfs:comment "Smoking vapors produced from electronic nicotene delivery systems." ;
rdfs:subClassOf obo:SCDO_0001079 .
obo:SCDO_0000182 a rdfs:Class ;
rdfs:label "Capillary Electrophoresis" ;
rdfs:comment "A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of proteins; nucleic acids; and carbohydrates. (Segen, Dictionary of Modern Medicine, 1992)" ;
rdfs:subClassOf obo:SCDO_0000424 .
a rdfs:Class .
obo:SCDO_0000811 a rdfs:Class ;
rdfs:label "Non-Proliferative Sickle Retinopathy" ;
rdfs:comment "Sickle retinopathy caused by direct damage or remodeling of the small blood vessels supplying the retina secondary to vaso-occlusion and local ischemia." ;
rdfs:subClassOf obo:SCDO_0001067 .
obo:SCDO_1000309 a rdfs:Class ;
rdfs:label "Hepatitis C Surface Antibody Test" ;
rdfs:comment "The determination of the surface antibody reaction of a sample to the Hepatitis C virus." ;
rdfs:subClassOf obo:SCDO_1000307 .
obo:SCDO_1000129 a rdfs:Class ;
rdfs:label "Maasai" ;
rdfs:comment "A smaller ethnic group, accounting for only about 0.7 percent of Kenya's population, with a similar number living in Tanzania. Maasais speak Maa, a Nilotic ethnic language from their origin in the Nile region of North Africa." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000230 a rdfs:Class ;
rdfs:label "Chronic Pain often Unclear Etiology" ;
rdfs:comment "The only complaint is the patient's self-report of pain that does not go away." ;
rdfs:subClassOf obo:SCDO_0000233 .
obo:HP_0001712 a rdfs:Class ;
rdfs:label "Left Ventricular Hypertrophy" ;
rdfs:comment "Enlargement or increased size of the heart left ventricle." ;
rdfs:subClassOf obo:HP_0001714 .
obo:SCDO_1000598 a rdfs:Class ;
rdfs:label "Folic Acid Use Status" ;
rdfs:comment "An indication of whether the respondent is using folic acid." ;
rdfs:subClassOf obo:SCDO_1000318 , obo:SCDO_1000590 .
obo:HP_0000820 a rdfs:Class ;
rdfs:label "Abnormality of the Thyroid Gland" ;
rdfs:comment "An abnormality of the thyroid gland." ;
rdfs:subClassOf obo:HP_0000818 .
obo:SCDO_0001326 a rdfs:Class ;
rdfs:label "Flow Cytometry" ;
rdfs:comment "Flow cytometry uses the principles of light scattering and fluorescence from fluorochrome molecules to generate specific multi-parameter data from particles and cells in the size range of 0.5um to 40um diameter." ;
rdfs:subClassOf obo:SCDO_0000896 .
obo:NCIT_C173396 a rdfs:Class ;
rdfs:label "Cerebral Blood Flow Velocity" ;
rdfs:comment "The rate of blood flow through the cerebral arteries." ;
rdfs:subClassOf obo:SCDO_0000213 .
obo:CMO_0000506 a rdfs:Class ;
rdfs:label "Hemoglobin Concentration" ;
rdfs:comment "The amount of hemoglobin, the red oxygen-carrying pigment of erythrocytes, in a specified volume of blood, as calculated from the optical density of a solution of lysed red cells in which hemoglobin has been converted to cyanomethemoglobin and measured with a spectrophotometer." ;
rdfs:subClassOf obo:CMO_0000508 .
obo:NCIT_C19332 a rdfs:Class ;
rdfs:label "Personal Attribute" ;
rdfs:comment "The distinguishing qualities or prominent aspects of an individual person." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:CMO_0000210 a rdfs:Class ;
rdfs:label "Activated Partial Thromboplastin Time" ;
rdfs:comment "The time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent. It is used to evaluate the intrinsic clotting system." ;
rdfs:subClassOf obo:CMO_0000204 .
obo:SCDO_0001068 a rdfs:Class ;
rdfs:label "Sickling Test" ;
rdfs:comment "A qualitative screening test for sickling haemoglobins, especially HbS. In the SCT, sodium metabisulfite or sodium dithionate is used to desolubilise haemoglobin S to the crystallised deoxygenated form, which causes the abnormal RBCs to sickle, as detected by light microscopy." ;
rdfs:subClassOf obo:SCDO_0000548 , obo:SCDO_1000577 .
obo:SCDO_1000663 a rdfs:Class ;
rdfs:label "Alkaline Phosphatase Blood Test" ;
rdfs:comment "A quantitative measurement of alkaline phosphatase present in a blood sample." ;
rdfs:subClassOf obo:NCIT_C74954 , obo:SCDO_0000133 .
obo:SCDO_1000078 a rdfs:Class ;
rdfs:label "Severe Sickle Cell Disease-S Beta Minus Thalassemia" ;
rdfs:comment "A form of sickle cell thalassemia, with a severe clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." ;
rdfs:subClassOf obo:SCDO_0001056 .
obo:HP_0100774 a rdfs:Class ;
rdfs:label "Hyperostosis" ;
rdfs:comment "Excessive growth or abnormal thickening of bone tissue." ;
rdfs:subClassOf obo:HP_0000924 .
obo:HP_0011856 a rdfs:Class ;
rdfs:label "Pica" ;
rdfs:comment "An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month." ;
rdfs:subClassOf obo:HP_0000708 , obo:SCDO_0000954 .
obo:SCDO_1000696 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin E Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin E." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:CMO_0000256 a rdfs:Class ;
rdfs:label "Urine Measurement" ;
rdfs:comment "Any measurement of urine, the fluid waste product excreted by the kidneys, or its components." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_0001020 a rdfs:Class ;
rdfs:label "Sampling Studies" ;
rdfs:comment "Studies in which a number of subjects are selected from all subjects in a defined population. Conclusions based on sample results may be attributed only to the population sampled." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_1000197 a rdfs:Class ;
rdfs:label "HIV Combination Test" ;
rdfs:comment "A test to detect both HIV antibodies and HIV antigens (a part of the virus) in blood." ;
rdfs:subClassOf obo:SCDO_0000571 .
obo:NCIT_C18772 a rdfs:Class ;
rdfs:label "Personal Medical History" ;
rdfs:comment "A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_1000157 .
obo:MP_0002329 a rdfs:Class ;
rdfs:label "Abnormal Blood Gas Level" ;
rdfs:comment "Anomaly in the amount of oxygen and carbon dioxide in the blood." ;
rdfs:subClassOf obo:HP_0002086 , obo:MP_0009642 .
obo:HP_0002098 a rdfs:Class ;
rdfs:label "Respiratory Distress" ;
rdfs:comment "Difficulty in breathing. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea." ;
rdfs:subClassOf obo:HP_0002086 .
obo:HP_0001872 a rdfs:Class ;
rdfs:label "Abnormal Thrombocyte Morphology" ;
rdfs:comment "An abnormality of platelets. Platelets, also known as thrombocytes, are non-nucleated disk-shaped cells mainly involved in blood coagulation." ;
rdfs:subClassOf obo:HP_0001871 .
obo:NCIT_C142494 a rdfs:Class ;
rdfs:label "Data Storage" ;
rdfs:comment "To maintain data by placing the data, or a copy of the data, onto an electronically accessible device for preservation (either in plain-text or encrypted format)." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:CHEBI_50858 a rdfs:Class ;
rdfs:label "Corticosteroid" ;
rdfs:comment "A natural or synthetic analogue of the hormones secreted by the adrenal gland." ;
rdfs:subClassOf obo:SCDO_0000057 .
obo:SCDO_0001070 a rdfs:Class ;
rdfs:label "deprecated Skin" ;
rdfs:comment "'The bodily system consisting of the skin and its associated structures, such as the hair, nails, sweat glands, and sebaceous glands. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000688 a rdfs:Class ;
rdfs:label "Hemoglobin Assay Results Recorded" ;
rdfs:comment "The hemoglobins for which assay results were recorded." ;
rdfs:subClassOf obo:SCDO_1000576 .
obo:HP_0003774 a rdfs:Class ;
rdfs:label "End Stage Kidney Disease" ;
rdfs:comment "A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine, greater than 3 months." ;
rdfs:subClassOf obo:SCDO_0000226 .
obo:SCDO_0001382 a rdfs:Class ;
rdfs:label "Hemoglobin Subunit Gamma" ;
rdfs:comment "Gamma Globin is a type of polypeptide chain that when in combination with alpha globin chains forms fetal hemoglobin. Beta-Hemoglobin subunits gamma-1 (147 aa, ~16 kDa) and gamma-2 (147 aa, ~16 kDa) are encoded by the human HBG1 and HBG2 gene respectively, in the beta-globin gene cluster. These proteins play a role in the transport of oxygen to tissues of the fetal body." ;
rdfs:subClassOf obo:SCDO_1000012 .
obo:NCIT_C97121 a rdfs:Class ;
rdfs:label "Pneumococcal 13-Valent Conjugate Vaccine" ;
rdfs:comment "A pneumococcal conjugate vaccine containing 13 different strains of the bacterium Streptococcus pneumoniae, used in children and studied in immunocompromised patients for the prevention of pneumococcal disease. The pneumococcal 13-valent conjugate vaccine contains capsular antigen polysaccharides derived from the S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F that are individually conjugated to a nontoxic diphtheria cross-reactive material (CRM) carrier protein (CRM197). Upon vaccination, pneumococcal 13-valent conjugate vaccine induces active immunization against 13 different serotypes of S. pneumoniae and protects against pneumococcal disease." ;
rdfs:subClassOf obo:NCIT_C97123 .
obo:SCDO_0001511 a rdfs:Class ;
rdfs:label "Renal Medullary Carcinoma" ;
rdfs:comment "Renal medullary carcinoma is a rare, aggressive subtype of renal cell carcinoma characterized by a large, white or tan, firm, infiltrative tumor with microabscess-like foci centered in the renal medulla, typically presenting with hematuria, abdominal/flank pain, weight loss and fever. It is associated with sickle cell trait and disease and metastasis to the bones and lungs is common at time of diagnosis." ;
rdfs:subClassOf obo:HP_0000077 , obo:SCDO_0001054 .
obo:HP_0001508 a rdfs:Class ;
rdfs:label "Failure to Thrive" ;
rdfs:comment "Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm." ;
rdfs:subClassOf obo:HP_0001507 .
obo:HP_0025547 a rdfs:Class ;
rdfs:label "Decreased Mean Corpuscular Hemoglobin Concentration" ;
rdfs:comment "Less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." ;
rdfs:subClassOf obo:HP_0025546 .
obo:SCDO_0000727 a rdfs:Class ;
rdfs:label "Measured Weight" ;
rdfs:comment "The weight of the participant in kilograms." ;
rdfs:subClassOf obo:SCDO_0000152 .
obo:MP_0005376 a rdfs:Class ;
rdfs:label "Metabolism/Homeostasis Phenotype" ;
rdfs:comment "The observable morphological and physiological characteristics related to a state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues or the processes that cause many of the chemical changes in living mammalian organisms that are manifested through development and lifespan." ;
rdfs:subClassOf obo:OGMS_0000023 .
obo:SCDO_1000320 a rdfs:Class ;
rdfs:label "Cigarette Smoking Status Diagnostic Instrument - Adult" ;
rdfs:comment "Questions asking an adult respondent about smoking status in his or her entire life." ;
rdfs:subClassOf obo:SCDO_1000319 .
obo:CMO_0000035 a rdfs:Class ;
rdfs:label "Blood Measurement" ;
rdfs:comment "A measurement of the blood, it's contents, cells or other factors contained within the blood." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_0000984 a rdfs:Class ;
rdfs:label "Renal Ischemia" ;
rdfs:comment "Inadequate blood flow to one or both kidneys, or nephrons, usually due to functional constriction or actual obstruction of blood vessels." ;
rdfs:subClassOf obo:HP_0000077 , obo:SCDO_0000665 , obo:SCDO_1000383 .
obo:SCDO_1000363 a rdfs:Class ;
rdfs:label "Hemoglobin Subunit Zeta" ;
rdfs:comment "A member of the alpha-globin family. In humans, it is encoded in the alpha-globin gene cluster or locus, located on chromosome 16. Two hemoglobin subunit zeta chains combine with two hemoglobin subunit epsilon chains to form the embryonic Hemoglobin Gower 1." ;
rdfs:subClassOf obo:SCDO_1000105 .
obo:SCDO_0001120 a rdfs:Class ;
rdfs:label "Substance Use History" ;
rdfs:comment "Assessment with the goal to obtain a relevant drug and alcohol history and perform a physical examination in order to establish whether there is a diagnosis of a substance use disorder." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:CMO_0000283 a rdfs:Class ;
rdfs:label "Partial Pressure of Carbon Dioxide" ;
rdfs:comment "The force per unit area attributable to the carbon dioxide, a colorless, odorless, incombustible gas formed during respiration and composed of one atom of carbon and two atoms of oxygen, dissolved in a specified volume of blood, defined as the force per unit area exerted by carbon dioxide in a mixture of gases in equilibrium with such a sample of blood at the same temperature." ;
rdfs:subClassOf obo:CMO_0000225 .
obo:SCDO_0006613 a rdfs:Class ;
rdfs:label "Material Transfer Agreement" ;
rdfs:comment "A material transfer agreement (MTA) is a type of legally enforceable contract employed by research institutions and companies to set the terms under which their materials and associated data may be obtained and used by others." ;
rdfs:subClassOf obo:SCDO_0300006 .
obo:NCIT_C17655 a rdfs:Class ;
rdfs:label "Reproductive History" ;
rdfs:comment "An account of all reproductive events and problems a person has experienced. An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:IDO_0000586 a rdfs:Class ;
rdfs:label "Infection" ;
rdfs:comment "A part of an extended organism that itself has as part a population of one or more infectious agents and that (1) exists as a result of processes initiated by members of the infectious agent population and is (2) clinically abnormal in virtue of the presence of this infectious agent population, or (3) has a disposition to bring clinical abnormality to immunocompetent organisms of the same Species as the host (the organism corresponding to the extended organism) through transmission of a member or offspring of a member of the infectious agent population." ;
rdfs:subClassOf obo:DOID_4 .
obo:DOID_1826 a rdfs:Class ;
rdfs:label "Epilepsy" ;
rdfs:comment "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." ;
rdfs:subClassOf obo:HP_0000708 .
obo:SCDO_0000462 a rdfs:Class ;
rdfs:label "G6PD" ;
rdfs:comment "This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene." ;
rdfs:subClassOf obo:SCDO_0000810 .
obo:SCDO_1000395 a rdfs:Class ;
rdfs:label "Gene Regulatory Component" ;
rdfs:comment "A gene regulatory component is a gene component that exerts a regulatory function." ;
rdfs:subClassOf obo:SCDO_1000394 .
obo:SCDO_1000108 a rdfs:Class ;
rdfs:label "HBB, SER9TYR" ;
rdfs:comment "A mutation where the serine in position 9 in the primary sequence of a beta-chain produced by the HBB gene is replaced by tyrosine. This mutation is one of 2 amino acid substitutions in the same beta chain that produces the asymptomatic Hemoglobin D-Agri, the other mutation being HBB, GLU121GLN, which on its own produces Hemoglobin D-Punjab." ;
rdfs:subClassOf obo:SCDO_0002305 .
obo:SCDO_0007192 a rdfs:Class ;
rdfs:label "Quantitative Hemoglobinopathy" ;
rdfs:comment "A hemoglobinopathy caused by a reduced or imbalanced synthesis of a normal globin chain or by a defect in the switch between synthesis of different types of normal hemoglobin." ;
rdfs:subClassOf obo:SCDO_0000552 .
obo:SCDO_0002475 a rdfs:Class ;
rdfs:label "Beta-Zero Thalassemia Mutation" ;
rdfs:comment "A mutation in the beta-globin gene, HBB, that results in absent beta globin synthesis." ;
rdfs:subClassOf obo:SCDO_0009731 .
obo:HP_0000842 a rdfs:Class ;
rdfs:label "Hyperinsulinemia" ;
rdfs:comment "An increased concentration of insulin in the blood." ;
rdfs:subClassOf obo:HP_0000818 , obo:HP_0011014 .
obo:SCDO_0000895 a rdfs:Class ;
rdfs:label "Phenotype of Sickle Cell Disease" ;
rdfs:comment "A (combination of) quality(ies) of some or all sickle cell disease individuals, determined by the interaction of the genetic make-up of these individuals (with regard to sickle cell disease) and their environment." ;
rdfs:subClassOf obo:HP_0000118 , obo:OGMS_0000028 .
obo:SCDO_1000056 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/C-Harlem" ;
rdfs:comment "Compound heterozygous inheritance of Hb S and Hb C-Harlem mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb C-Harlem involves two substitutions in each beta-chain: the first being identical to that found in Hb S, and the second being a substitution of aspartic acid at position 73 by asparagine (beta73Asp>Asn)." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:NCIT_C124065 a rdfs:Class ;
rdfs:label "Hepatic Iron Concentration" ;
rdfs:comment "A measurement of the concentration of iron in the liver as an estimate of body iron load." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:HP_0000819 a rdfs:Class ;
rdfs:label "Diabetes Mellitus" ;
rdfs:comment "A group of abnormalities characterized by hyperglycemia and glucose intolerance." ;
rdfs:subClassOf obo:HP_0000818 , obo:HP_0011014 , obo:SCDO_0000267 .
obo:SCDO_1000211 a rdfs:Class ;
rdfs:label "Dominant Sickle Cell Disease" ;
rdfs:comment "Clinical sickle cell disease in the heterozygous state due to an additional mutation on the same allele as the beta S mutation." ;
rdfs:subClassOf obo:NCIT_C95534 , obo:SCDO_0001051 .
obo:SCDO_1000449 a rdfs:Class ;
rdfs:label "Low-Dose Ketamine Infusion" ;
rdfs:comment "An infusion of ketamine at a low dose (up to 5 µg/kg/min)." ;
rdfs:subClassOf obo:SCDO_1000448 .
obo:SCDO_1000587 a rdfs:Class ;
rdfs:label "Blood Type O Negative" ;
rdfs:comment "A blood type containing no surface markers on red blood cells, with the absence of a protein called rhesus (Rh) factor." ;
rdfs:subClassOf obo:HP_0032224 .
obo:SCDO_1000889 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Difficulty in Breathing Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether a participant has difficulty in breathing." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:NCIT_C102988 a rdfs:Class ;
rdfs:label "Patient Reported Outcomes Measurement Information System (PROMIS)" ;
rdfs:comment "A project to develop standards for the collection and analysis of patient-reported health status data using a system of highly reliable, precise measures for physical, mental, and social well-being. Patients are asked a series of rigorously reviewed questions covering common domains and metrics across differing conditions and treatments. The questions can be administered in short forms or adaptively through computerized adaptive testing and reports can be generated to allow clinicians to better understand how treatments might affect the quality of life of their patients." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_1000849 a rdfs:Class ;
rdfs:label "Acute Clinical Visit" ;
rdfs:comment "A clinical visit occuring because of an acute (severe with sudden onset) health condition." ;
rdfs:subClassOf obo:NCIT_C103165 .
obo:SCDO_1000067 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/Beta Zero Thalassaemia" ;
rdfs:comment "When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a null mutation, called beta-zero, because of the resulting inability to synthesize any beta-globin chain." ;
rdfs:subClassOf obo:SCDO_1000107 .
obo:HP_0011991 a rdfs:Class ;
rdfs:label "Abnormal Neutrophil Count" ;
rdfs:comment "A deviation from the normal range of neutrophil cell counts in the circulation." ;
rdfs:subClassOf obo:HP_0001874 , obo:HP_0002715 .
obo:NCIT_C30142 a rdfs:Class ;
rdfs:label "History of Transfusion" ;
rdfs:comment "An account of all experiences related to the receipt of blood, WBC, platelets, and/or other blood components." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:CMO_0000094 a rdfs:Class ;
rdfs:label "Respiratory System Measurement" ;
rdfs:comment "A measurement to assess the morphological or physiological state of the respiratory system or portion of the respiratory system." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_0000247 a rdfs:Class ;
rdfs:label "obsolete Clinical Conference" ;
rdfs:comment "'Work that consists of a conference of physicians on their observations of a patient at the bedside, regarding the physical state, laboratory and other diagnostic findings, clinical manifestations, results of current therapy, etc. A clinical conference usually ends with a confirmation or correction of clinical findings by a pathological diagnosis performed by a pathologist. Clinical conference is often referred to as a clinico-pathological conference. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000941 .
obo:SCDO_0000292 a rdfs:Class ;
rdfs:label "Corticosteroid-Induced Vaso-Occlusive Adverse Event" ;
rdfs:comment "A corticosteroid-induced adverse event that has the outcome of vaso-occlusion." ;
rdfs:subClassOf obo:SCDO_0000291 .
obo:SCDO_1000091 a rdfs:Class ;
rdfs:label "deprecated Sickle beta plus thalassemia" ;
rdfs:comment "'Sb+ thalassemia is an inherited condition. Hemoglobin S comes from one parent and Beta plus thalassemia comes from the other parent. Instead of appearing round (like donuts), red blood cells are somewhat small, pale and misshapen. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0002039 a rdfs:Class ;
rdfs:label "Zinc Deficiency" ;
rdfs:comment "A deficiency of the essential metal Zinc; an essential cofactor for many enzymes. Zinc deficiency is caused by a lack of zinc in the diet, loss of zinc after absorption, for example through loss through burns, inability to absorb Zinc, or increased loss through exercise." ;
rdfs:subClassOf obo:SCDO_1000261 .
obo:HP_0012379 a rdfs:Class ;
rdfs:label "Abnormal Enzyme/Coenzyme Activity" ;
rdfs:comment "An altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_1000465 a rdfs:Class ;
rdfs:label "Mode of Providing Consent" ;
rdfs:comment "A method in which a patient or their legal representative provides consent." ;
rdfs:subClassOf obo:SCDO_0007597 .
obo:HP_0045040 a rdfs:Class ;
rdfs:label "Abnormal Lactate Dehydrogenase Level" ;
rdfs:comment "A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate." ;
rdfs:subClassOf obo:HP_0012379 .
obo:HP_0030248 a rdfs:Class ;
rdfs:label "Mesenteric Venous Thrombosis" ;
rdfs:comment "A clot that obstructs blood flow in a mesenteric vein (the superior and the inferior mesenteric vein drain blood from the small and large intestine)." ;
rdfs:subClassOf obo:HP_0001977 .
obo:SCDO_0006461 a rdfs:Class ;
rdfs:label "Acutely Severe Anemia" ;
rdfs:comment "Aplasia or hemolysis may be precipitated by another illness/infection in sickle cell disease patients. Acutely severe anemia is defined as Hb < 5g/dl or a recent acute drop in HB > 2g/dl below the individual's steady state value. If no steady state value is available, it can be detected by the presence of acutely symptomatic anemia (i.e. tachycardia, cardiac failure, shock)." ;
rdfs:subClassOf obo:HP_0001903 , obo:SCDO_1000000 .
obo:SCDO_0000683 a rdfs:Class ;
rdfs:label "Lactate Dehydrogenase Test" ;
rdfs:comment "A bioassay to measure levels of lactate dehydrogenase, an enzyme released during tissue damage and injury." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_0000705 a rdfs:Class ;
rdfs:label "Lung Volume Test" ;
rdfs:comment "Clinical assessment to determine the volume of gas within an individual's lung." ;
rdfs:subClassOf obo:SCDO_0000942 .
obo:SCDO_0001085 a rdfs:Class ;
rdfs:label "Social Role" ;
rdfs:comment "A role that is ascribed to individuals in a community." ;
rdfs:subClassOf obo:SCDO_0001083 .
obo:SCDO_0001210 a rdfs:Class ;
rdfs:label "Urine Albumin Excretion Rate" ;
rdfs:comment "The amount of albumin excreted into the urine within a specified period of time." ;
rdfs:subClassOf obo:SCDO_0001207 .
obo:SCDO_0000161 a rdfs:Class ;
rdfs:label "Brain Electrical Activity" ;
rdfs:comment "Voltages between parts of the brain that are detectable with an electroencephalograph." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_1000348 a rdfs:Class ;
rdfs:label "Sleep Disorders Screener" ;
rdfs:comment "A questionnaire to assess sleep disorders, a broad group of disorders that can be caused by endogenous disturbances in the sleep-wake or timing cycles (American Psychiatric Association, 2000)." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_0000410 a rdfs:Class ;
rdfs:label "Echocardiography Machine" ;
rdfs:comment "A machine used for ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:NCIT_C26548 a rdfs:Class ;
rdfs:label "Gene Product" ;
rdfs:comment "A protein, RNA or a complex that contains proteins and/or RNA." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:NCIT_C49131 a rdfs:Class ;
rdfs:label "Diagnostic Histology Test" ;
rdfs:comment "A diagnostic test used to examine and define microscopic tissue structure, composition, or etiology. The test results are often used by a clinician to diagnose disease or disordered function." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_0000525 a rdfs:Class ;
rdfs:label "Hemoglobin D Trait" ;
rdfs:comment "The inheritance of the gene for hemoglobin D from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ;
rdfs:subClassOf obo:NCIT_C95534 .
obo:DOID_0111033 a rdfs:Class ;
rdfs:label "African Iron Overload" ;
rdfs:comment "A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums." ;
rdfs:subClassOf obo:SCDO_1000281 .
obo:NCIT_C64387 a rdfs:Class ;
rdfs:label "Millimole per Liter" ;
rdfs:comment "A unit of concentration (molarity unit) equal to one millimole of solute per liter of solution." ;
rdfs:subClassOf obo:UO_0000051 .
obo:HP_0011123 a rdfs:Class ;
rdfs:label "Skin Inflammation" ;
rdfs:comment "The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes." ;
rdfs:subClassOf obo:HP_0011122 .
obo:SCDO_1000225 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype AC" ;
rdfs:comment "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin C. Individuals with this genotype are known to be carriers of the hemoglobin C trait." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_0001299 a rdfs:Class ;
rdfs:label "Evaluation Studies" ;
rdfs:comment "Works consisting of studies determining the effectiveness or utility of processes, personnel, and equipment." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:UO_0000272 a rdfs:Class ;
rdfs:label "mmHg" ;
rdfs:comment "A unit of pressure equal to the amount of fluid pressure one millimeter deep in mercury at zero degrees centigrade on Earth." ;
rdfs:subClassOf obo:UO_0000109 .
obo:HP_0001511 a rdfs:Class ;
rdfs:label "Intrauterine Growth Restriction" ;
rdfs:comment "An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age." ;
rdfs:subClassOf obo:HP_0001197 , obo:HP_0001507 .
obo:SCDO_1000214 a rdfs:Class ;
rdfs:label "deprecated Disease Caused by C/S Antilles Genotype" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000252 a rdfs:Class ;
rdfs:label "obsolete Clinical Study" ;
rdfs:comment "'A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000941 .
obo:SCDO_0000070 a rdfs:Class ;
rdfs:label "Aquatic Rehabilitation" ;
rdfs:comment "Exercises performed in or underwater for conditioning or rehabilitation (e.g., in injured athletes or patients with joint diseases)." ;
rdfs:subClassOf obo:SCDO_0000978 .
obo:NCIT_C155312 a rdfs:Class ;
rdfs:label "Sickle Cell Chronic Lung Disease" ;
rdfs:comment "A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present." ;
rdfs:subClassOf obo:SCDO_0000232 , obo:SCDO_0000895 .
obo:SCDO_1000298 a rdfs:Class ;
rdfs:label "Hepatitis B Virus Surface Antigen Test" ;
rdfs:comment "A deteremination of the presence of hepatitis B virus surface antigen." ;
rdfs:subClassOf obo:SCDO_0000616 .
obo:HP_0012759 a rdfs:Class ;
rdfs:label "Neurodevelopmental Abnormality" ;
rdfs:comment "A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities. This term should be used to describe abnormalities with onset in the developmental period." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_1000110 a rdfs:Class ;
rdfs:label "HBB, GLY16ARG" ;
rdfs:comment "A mutation where the glycine in position 16 in the primary sequence of a beta-chain produced by the HBB gene is replaced by arginine." ;
rdfs:subClassOf obo:SCDO_0002305 .
obo:NCIT_C18133 a rdfs:Class ;
rdfs:label "Missense Mutation" ;
rdfs:comment "A single base pair substitution that alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position. Some missense mutations will alter the function of the protein." ;
rdfs:subClassOf obo:NCIT_C62200 .
obo:SCDO_0001165 a rdfs:Class ;
rdfs:label "Trail Making Test" ;
rdfs:comment "An interviewer-administered, two-part test that requires the respondent to organize numerical and alphabetical sequences that are randomly distributed on a piece of paper. The protocol includes instructions for correcting mistakes and instructions for scoring based on speed and accuracy." ;
rdfs:subClassOf obo:SCDO_0001304 .
obo:DOID_0060181 a rdfs:Class ;
rdfs:label "Ischemic Cholitis" ;
rdfs:comment "A colitis caused by inadequate blood supply to the colon." ;
rdfs:subClassOf obo:HP_0025031 .
obo:SCDO_0000490 a rdfs:Class ;
rdfs:label "Health Insurance Coverage" ;
rdfs:comment "Whether the respondent is covered by health insurance or some other form of health care coverage at the time of the interview." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0000496 .
obo:NCIT_C92755 a rdfs:Class ;
rdfs:label "Chorionic Villus Sampling" ;
rdfs:comment "The biopsy of placental tissue containing the chorionic villi from the maternal uterus in early pregnancy to diagnose fetal genetic defects." ;
rdfs:subClassOf obo:SCDO_0000919 .
obo:NCIT_C116942 a rdfs:Class ;
rdfs:label "Developmental Delay" ;
rdfs:comment "Failure to meet, or late achievement of developmental milestones." ;
rdfs:subClassOf obo:HP_0012759 .
obo:SCDO_0006832 a rdfs:Class ;
rdfs:label "Ascorbic Acid Deficiency" ;
rdfs:comment "A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)" ;
rdfs:subClassOf obo:SCDO_1000261 .
obo:SCDO_0001007 a rdfs:Class ;
rdfs:label "Retinal Cryopexy" ;
rdfs:comment "A procedure that uses intense cold to induce a chorioretinal scar and to destroy retinal or choroidal tissue." ;
rdfs:subClassOf obo:SCDO_0000833 .
obo:SCDO_1000595 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Penicillin V Use Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether the respondent is using penicillin V as a prophylaxis against bacterial infections." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000145 a rdfs:Class ;
rdfs:label "National Guideline for the Control and Management of Sickle Cell Disease" ;
rdfs:comment "Guidelines for the management of specific clinical problems and protocols for various therapeutic procedures for patients with sickle cell disease and thalassaemia; to facilitate uniformity and standardization of care across different disciplines." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_1000250 a rdfs:Class ;
rdfs:label "deprecated Abnormal Molecular Function" ;
rdfs:comment "A phenotype in which a specific molecular function is abnormal." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0011025 a rdfs:Class ;
rdfs:label "Abnormal Cardiovascular System Physiology" ;
rdfs:comment "Abnormal functionality of the cardiovascular system." ;
rdfs:subClassOf obo:HP_0001626 .
obo:SCDO_0001136 a rdfs:Class ;
rdfs:label "deprecated Systemic" ;
rdfs:comment "'Affecting a number of tissues relating to the entire organism as distinguished from and of its individual parts. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000029 a rdfs:Class ;
rdfs:label "obsolete NAS (non-traceable author statement)" ;
rdfs:comment "'used in all cases where the author makes a statement that a curator wants to capture but for which there are neither results presented nor a specific reference cited in the source used to make the annotation. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:SCDO_0000615 a rdfs:Class ;
rdfs:label "deprecated Immune System" ;
rdfs:comment "The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components." ;
rdfs:subClassOf obo:SCDO_0000511 .
obo:SCDO_0009279 a rdfs:Class ;
rdfs:label "Unstable Hemoglobin" ;
rdfs:comment "Hemoglobin with decreased solubility in the red cell due to substitutions in the primary sequence of globin which alters the tertiary or quaternary structure of the molecule and results in a globin polypeptide/hemoglobin tetramer that is unstable and precipitates intracellularly, reducing the red blood cell lifespan." ;
rdfs:subClassOf obo:SCDO_0003807 .
obo:NCIT_C51774 a rdfs:Class ;
rdfs:label "Never Been Married" ;
rdfs:comment "Indicates a person who has never been married or whose marriages have been annulled." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_0000359 a rdfs:Class ;
rdfs:label "deprecated terms" ;
rdfs:comment "Terms that are no longer being used in the ontology." .
obo:DUO_0000025 a rdfs:Class ;
rdfs:label "Time Limit on Use" ;
rdfs:comment "This should be coupled with an integer value indicating the number of months." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_1000353 a rdfs:Class ;
rdfs:label "Spirometry - Child" ;
rdfs:comment "Measurement of the breathing capacity of a child's lung by means of a spirometer." ;
rdfs:subClassOf obo:NCIT_C85397 .
obo:SCDO_0006860 a rdfs:Class ;
rdfs:label "HBG1 and/or HBG2 Mutations" ;
rdfs:comment "Mutations in the HBG1 and/or HBG2 genes. Such mutations can lead to variably increased levels of fetal hemoglobin (Hb) (Hb F, alpha2gamma2) in the syndrome of hereditary persistence of fetal Hb (HPFH)." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_1000766 a rdfs:Class ;
rdfs:label "Year 1900 - Current" ;
rdfs:comment "An answer to a question where the answer is a year between 1900 and the current year, selected from a provided list of years." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_1000602 a rdfs:Class ;
rdfs:label "Pneumococcal Vaccination Status" ;
rdfs:comment "An indication of whether the respondent is up to date with their pneumococcal vaccinations." ;
rdfs:subClassOf obo:SCDO_1000590 .
obo:SCDO_0000931 a rdfs:Class ;
rdfs:label "Prospective Studies" ;
rdfs:comment "Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group." ;
rdfs:subClassOf obo:SCDO_0000263 .
obo:SCDO_0000438 a rdfs:Class ;
rdfs:label "deprecated Epidemiologic Study Characteristics as Topic" ;
rdfs:comment "Types and formulations of studies used in epidemiological and clinical research." ;
rdfs:subClassOf obo:SCDO_0000990 .
obo:SCDO_0300008 a rdfs:Class ;
rdfs:label "Mandatory Reporting" ;
rdfs:comment "A legal requirement that designated types of information acquired by professionals or institutions in the course of their work be reported to appropriate authorities." ;
rdfs:subClassOf obo:SCDO_0300006 .
obo:SCDO_1000033 a rdfs:Class ;
rdfs:label "Diagnostic Instrument" ;
rdfs:comment "A research instrument consisting of a series of questions and other prompts for the purpose of gathering information from respondents to assist with differential diagnosis." ;
rdfs:subClassOf obo:SCDO_1000032 .
obo:SCDO_0000835 a rdfs:Class ;
rdfs:label "Ophthalmoscopy" ;
rdfs:comment "Examination of the interior of the eye with an ophthalmoscope." ;
rdfs:subClassOf obo:NCIT_C38060 .
obo:NCIT_C38141 a rdfs:Class ;
rdfs:label "Pneumococcal 7-Valent Conjugate Vaccine" ;
rdfs:comment "An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein." ;
rdfs:subClassOf obo:NCIT_C97123 .
obo:SCDO_0000319 a rdfs:Class ;
rdfs:label "D57.211 Sickle-cell/Hb-C disease with acute chest syndrome" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000318 .
obo:SCDO_1000827 a rdfs:Class ;
rdfs:label "Normal Mean Corpuscular Hemoglobin Concentration" ;
rdfs:comment "When the amount of hemoglobin in a given volume of packed red blood cells falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:SCDO_1000337 a rdfs:Class ;
rdfs:label "Substances - Lifetime Use Diagnostic Instrument" ;
rdfs:comment "Questions from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) related to their lifetime use of illicit and prescribed substances." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:HP_0000952 a rdfs:Class ;
rdfs:label "Jaundice" ;
rdfs:comment "Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." ;
rdfs:subClassOf obo:HP_0011121 , obo:SCDO_0000954 .
obo:SCDO_1000708 a rdfs:Class ;
rdfs:label "Sex of Spouse" ;
rdfs:comment "The sex of the respondent's spouse, as provided by the respondent." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:HP_0031368 a rdfs:Class ;
rdfs:label "Intestinal Perforation" ;
rdfs:comment "A hole (perforation) in the wall of the intestine." ;
rdfs:subClassOf obo:SCDO_1000433 .
obo:SCDO_1000084 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/Quebec-Chori" ;
rdfs:comment "A compound heterozygous genotype, involving the mutations for Hemoglobin S and Hemoglobin Quebec Chori, which shows an electrophoretic pattern similar to that of the Hb A/S Genotype, but shows sickling." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:SCDO_1000833 a rdfs:Class ;
rdfs:label "Normal Lactate Dehydrogenase Level" ;
rdfs:comment "When the level of the enzyme lactate dehydrogenase in the serum is in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:SCDO_1000261 a rdfs:Class ;
rdfs:label "Avitaminosis" ;
rdfs:comment "A condition due to a deficiency of one or more essential vitamins. (Dorland, 27th ed)" ;
rdfs:subClassOf obo:HP_0000118 .
obo:HP_0005318 a rdfs:Class ;
rdfs:label "Cerebral Vasculitis" ;
rdfs:comment "Inflammation of the blood vessels within the brain." ;
rdfs:subClassOf obo:HP_0002060 .
obo:SCDO_0000399 a rdfs:Class ;
rdfs:label "Drug Intake" ;
rdfs:comment "The amount of drug substances taken into the body." ;
rdfs:subClassOf obo:SCDO_0000487 .
obo:HP_0002341 a rdfs:Class ;
rdfs:label "Cervical Cord Compression" ;
rdfs:comment "Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_1000467 a rdfs:Class ;
rdfs:label "Verbal Consent" ;
rdfs:comment "When the participant communicates consent orally rather than by filling out and signing a written form. Normally a witness is present when verbal consent is given." ;
rdfs:subClassOf obo:SCDO_1000465 .
obo:SCDO_0000545 a rdfs:Class ;
rdfs:label "Hemoglobin O-Arab Trait" ;
rdfs:comment "The inheritance of hemoglobin O-Arab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ;
rdfs:subClassOf obo:NCIT_C95534 .
obo:SCDO_0000791 a rdfs:Class ;
rdfs:label "Nasal Decongestants" ;
rdfs:comment "Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)" ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001129 .
obo:HP_0005560 a rdfs:Class ;
rdfs:label "Imbalanced Hemoglobin Synthesis" ;
rdfs:comment "Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia." ;
rdfs:subClassOf obo:HP_0001877 , obo:SCDO_1000060 .
obo:SCDO_0000258 a rdfs:Class ;
rdfs:label "obsolete Clinical Trial, Phase III" ;
rdfs:comment "'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques after phase II trials. A large enough group of patients is studied and closely monitored by physicians for adverse response to long-term exposure, over a period of about three years in either the United States or a foreign country. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000254 .
obo:SCDO_1000573 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - SCD Test Result Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's SCD test result." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000816 a rdfs:Class ;
rdfs:label "Absent Hemoglobin D-Punjab" ;
rdfs:comment "A lack of production of hemoglobin D-Punjab." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_0000218 a rdfs:Class ;
rdfs:label "Child Health Questionnaire (CHQ)" ;
rdfs:comment "The Child Health Questionnaire (CHQ) is a family of general quality of life surveys that measures 14 unique physical and psychosocial concepts. The parent form is available in 2 lengths - the CHQ-PF50 and the CHQ-PF28. The child self-reported version of the CHQ consists of 87 items (CHQ-CF87)." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:SCDO_0000388 a rdfs:Class ;
rdfs:label "Disaster" ;
rdfs:comment "Sudden calamitous events producing great material damage, loss, and distress. They are the result of natural phenomena such as earthquakes, floods, etc. Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community." ;
rdfs:subClassOf obo:SCDO_0000897 .
obo:SCDO_1000134 a rdfs:Class ;
rdfs:label "Somali" ;
rdfs:comment "A Cushitic speaking people comprising a small minority of Kenya's population. The Somali tend large herds of cattle, goats, sheep, and camels in the dry, arid lands of Northern Kenya. They are politically well organized and are united by both family allegiances and political treaties. The Somali also produce exquisitely carved headrests and woven artifacts." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:NCIT_C81229 a rdfs:Class ;
rdfs:label "Alcohol Use History" ;
rdfs:comment "A description of an individual's current and past experience with alcoholic beverage consumption." ;
rdfs:subClassOf obo:SCDO_0001120 .
obo:SCDO_0000556 a rdfs:Class ;
rdfs:label "Hepatic Span" ;
rdfs:comment "The distance between the lower border of the liver in the mid-clavicular line, and the upper border of the liver in the mid-clavicular line." ;
rdfs:subClassOf obo:CMO_0000021 .
obo:SCDO_0000010 a rdfs:Class ;
rdfs:label "Acetaminophen" ;
rdfs:comment "Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage." ;
rdfs:subClassOf obo:CHEBI_35493 , obo:SCDO_0000809 .
obo:SCDO_0000536 a rdfs:Class ;
rdfs:label "Hemoglobin Lepore Boston Disease" ;
rdfs:comment "A variant of Hemoglobin Lepore Syndrome. Crossover occurs between glutamine at position 87 of delta chain and histidine at position 116 of beta chain. It is associated with unusual high levels of Hb F. This is the only one of the three variants of described in association with HbS." ;
rdfs:subClassOf obo:NCIT_C141366 .
obo:NCIT_C2905 a rdfs:Class ;
rdfs:label "Bone Marrow Hyperplasia" ;
rdfs:comment "Increase in the number of hematopoietic cells in the bone marrow. It may involve all or individual hematopoietic cell lines." ;
rdfs:subClassOf obo:HP_0001871 .
obo:SCDO_1000338 a rdfs:Class ;
rdfs:label "Sleep Disorders Screener - Children" ;
rdfs:comment "A 26-item, self-administered scale completed by the parent that assesses the child's sleep behaviors in the past 6 months. The scale includes six subscales: disorders of initiating and maintaining sleep (items 1, 2, 3, 4, 5, 10, 11); sleep breathing disorders (items 13, 14, 15); disorders of arousal (items 17, 20, 21); sleep-wake transition disorders (items 6, 7, 8, 12, 18, 19); disorders of excessive somnolence (items 22, 23, 24, 25, 26); and sleep hyperhidrosis (score of the items 9, 16). Each item is rated on a 5-point, Likert-type scale (1 = Never; 5 = Always [daily]). Scores from individual items of each subscale are added together to give a subscale score, with higher scores indicating greater symptoms. Scores from the individual subscales can be added together to give a total score." ;
rdfs:subClassOf obo:SCDO_1000348 .
obo:SCDO_1000486 a rdfs:Class ;
rdfs:label "deprecated Radio Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:OBI_1110053 a rdfs:Class ;
rdfs:label "Cancer" ;
rdfs:comment "A disease characterized by abnormal and uncontrolled cell division." ;
rdfs:subClassOf obo:SCDO_0000267 .
obo:SCDO_1000822 a rdfs:Class ;
rdfs:label "Normal Red Blood Cell Count" ;
rdfs:comment "When the number of red blood cells in a specified volume of blood falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:OPMI_0000028 a rdfs:Class ;
rdfs:label "Other" ;
rdfs:comment "An answer to question that is not enumerated in the list and then may be entered with free text in a separate text box" ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:CMO_0000921 a rdfs:Class ;
rdfs:label "Platelet Measurement" ;
rdfs:comment "Any measurement of platelets, the disk-shaped structures found in the blood of mammals which play a vital role in blood coagulation. Platelets lack nuclei and DNA but contain active enzymes and mitochondria." ;
rdfs:subClassOf obo:CMO_0000036 .
obo:SCDO_1000897 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Jaundice Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether a participant has jaundice." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:GSSO_003239 a rdfs:Class ;
rdfs:label "Ethical Principle" ;
rdfs:comment "Principles which provide a framework within which ethical dilemmas and other problems may be analyzed." ;
rdfs:subClassOf obo:SCDO_1000430 .
obo:SCDO_1000074 a rdfs:Class ;
rdfs:label "Hemoglobin S-Oman" ;
rdfs:comment "A form of hemoglobin caused by two mutations in a beta-globin chain, the classic beta S mutation (beta6 Glu> Val) and a beta121 Glu > Lys mutation identical to that of Hb-O Arab. The hemoglobin variant has reduced solubility and there is an apparent increase in red cell sickling tendency. It is reported to cause a rare dominant form of sickle cell disease, Sickle Cell Disease A/S-Oman." ;
rdfs:subClassOf obo:SCDO_1000082 .
obo:SCDO_1000607 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Red Blood Cell Count Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the red blood cell count in the respondent's blood, as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001091 a rdfs:Class ;
rdfs:label "Socioeconomic Status" ;
rdfs:comment "The combination of one's social class and income level. Includes socioeconomic differences between individuals or groups." ;
rdfs:subClassOf obo:SCDO_0001090 .
obo:SCDO_0001005 a rdfs:Class ;
rdfs:label "Reticulocyte Count by Hematology Analyzer" ;
rdfs:comment "A reticulocyte count that was performed with an electronic haematology analyzer." ;
rdfs:subClassOf obo:SCDO_0001004 .
obo:SCDO_0000298 a rdfs:Class ;
rdfs:label "Cross-Sectional Studies" ;
rdfs:comment "Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with longitudinal studies which are followed over a period of time." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:ICO_0000255 a rdfs:Class ;
rdfs:label "Participant Withdrawal Process" ;
rdfs:comment "A directive information entity that prescribes some process for withdraw from another planned process." ;
rdfs:subClassOf obo:SCDO_1000422 .
obo:SCDO_1000044 a rdfs:Class ;
rdfs:label "HBB, ASP73ASN" ;
rdfs:comment "A mutation where the aspartic acid in position 73 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation is found as a single alteration in Hemoglobin Korle Bu and is one of the two contributing mutations to the production of Hemoglobin C-Harlem." ;
rdfs:subClassOf obo:SCDO_0009786 .
obo:SCDO_0006921 a rdfs:Class ;
rdfs:label "Hemoglobin Variant" ;
rdfs:comment "Hemoglobin with altered structural and biochemical properties." ;
rdfs:subClassOf obo:NCIT_C16676 , obo:SCDO_0009613 .
obo:SCDO_0001089 a rdfs:Class ;
rdfs:label "Social Values" ;
rdfs:comment "Abstract standards or empirical variables in social life which are believed to be important and/or desirable." ;
rdfs:subClassOf obo:SCDO_0000299 .
obo:HP_0000815 a rdfs:Class ;
rdfs:label "Hypergonadotropic Hypogonadism" ;
rdfs:comment "Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay." ;
rdfs:subClassOf obo:HP_0000080 .
obo:SCDO_1000032 a rdfs:Class ;
rdfs:label "Diagnostic Tool" ;
rdfs:comment "A diagnostic instrument, technique, laboratory assay or test, or method of patient examination used for differential diagnosis." ;
rdfs:subClassOf obo:SCDO_0000379 .
obo:SCDO_0001084 a rdfs:Class ;
rdfs:label "Social Isolation" ;
rdfs:comment "The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication." ;
rdfs:subClassOf obo:SCDO_0001083 .
obo:SCDO_1000819 a rdfs:Class ;
rdfs:label "Decreased Partial Pressure of Oxygen" ;
rdfs:comment "An abnormal reduction in the pressure exerted by oxygen dissolved in the blood." ;
rdfs:subClassOf obo:MP_0002329 .
obo:SCDO_1000111 a rdfs:Class ;
rdfs:label "HBB, ASN19LYS" ;
rdfs:comment "A mutation where the asparargine acid in position 19 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine." ;
rdfs:subClassOf obo:SCDO_0002305 .
obo:SCDO_0000828 a rdfs:Class ;
rdfs:label "Oliguria" ;
rdfs:comment "Low output of urine, defined as an output below 5mL/kg/hr over 6 hours." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_1000830 a rdfs:Class ;
rdfs:label "Normal Serum Alanine Aminotransferase" ;
rdfs:comment "When the level of serum alanine aminotransferase is in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:NCIT_C34887 a rdfs:Class ;
rdfs:label "Peri-Operative Pain" ;
rdfs:comment "A sensation of discomfort secondary to surgery." ;
rdfs:subClassOf obo:SCDO_0000851 .
obo:SCDO_0001997 a rdfs:Class ;
rdfs:label "Crystallisation of Hemoglobin" ;
rdfs:comment "The process whereby a mutation in a hemoglobin molecule causes conformational changes in the hemoglobin molecule, which cause increased hydrophobicity of the molecule, which result in the formation of crystals consisting of the mutated hemoglobin molecules. This type of crystallisation is observed in hemoglobins with the HbC mutation." ;
rdfs:subClassOf obo:SCDO_1000253 .
obo:HP_0012639 a rdfs:Class ;
rdfs:label "Abnormal Nervous System Morphology" ;
rdfs:comment "A structural anomaly of the nervous system." ;
rdfs:subClassOf obo:HP_0000707 .
obo:SCDO_0001328 a rdfs:Class ;
rdfs:label "Focal Dystonia" ;
rdfs:comment "A rare neurologic movement disorder characterized by sustained muscle contractions of a single body region, usually producing twisting and repetitive movements or abnormal postures or positions." ;
rdfs:subClassOf obo:HP_0012638 .
obo:DOID_1188 a rdfs:Class ;
rdfs:label "Mononeuropathy" ;
rdfs:comment "A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_0001379 a rdfs:Class ;
rdfs:label "HBA2" ;
rdfs:comment "This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA1." ;
rdfs:subClassOf obo:SCDO_1000361 .
obo:CMO_0001321 a rdfs:Class ;
rdfs:label "Blood Gas Measurement" ;
rdfs:comment "Any measurement of a gas or gases dissolved in the blood, including oxygen, nitrogen carbon dioxide and/or hydrogen." ;
rdfs:subClassOf obo:CMO_0000035 .
obo:SCDO_0000524 a rdfs:Class ;
rdfs:label "Hemoglobin D Disease" ;
rdfs:comment "An autosomal recessive hemoglobinopathy characterized by production of abnormal variant hemoglobin known as hemoglobin D, with no or mild clinical manifestations (splenomegaly, very mild anemia)." ;
rdfs:subClassOf obo:SCDO_0008262 .
obo:SCDO_0000255 a rdfs:Class ;
rdfs:label "obsolete Clinical Trial, Phase I" ;
rdfs:comment "'Work that is the report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on a small number of healthy persons and conducted over the period of about a year in either the United States or a foreign country. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000254 .
obo:NCIT_C29107 a rdfs:Class ;
rdfs:label "IV fluids" ;
rdfs:comment "A sterile liquid preparation infused into a vein. IV fluid is prescribed as a replacement of fluid, electrolytes, calories, vitamins, and other nutritional substances. In addition, IV fluids are used to administer blood products and medications such as chemotherapy. Examples of IV fluids include Normal Saline, Ringers Solution, and Lactated Ringers Solution." ;
rdfs:subClassOf obo:SCDO_0000922 .
obo:NCIT_C78598 a rdfs:Class ;
rdfs:label "Posterior Reversible Leukoencephalopathy" ;
rdfs:comment "An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment." ;
rdfs:subClassOf obo:HP_0012638 .
obo:HP_0020061 a rdfs:Class ;
rdfs:label "Abnormal Hemoglobin Concentration" ;
rdfs:comment "Any deviation from the normal concentration of hemoglobin in the blood." ;
rdfs:subClassOf obo:HP_0001877 , obo:SCDO_0009613 .
obo:SCDO_1000004 a rdfs:Class ;
rdfs:label "Renal Replacement Therapy" ;
rdfs:comment "Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys." ;
rdfs:subClassOf obo:SCDO_0001129 .
obo:SCDO_0000385 a rdfs:Class ;
rdfs:label "Diffusion Capacity Test" ;
rdfs:comment "Clinical assessment to determine the capacity of an individual's lung to exchange gases (e.g., oxygen and carbon dioxide) across the alveolar-capillary interface." ;
rdfs:subClassOf obo:SCDO_0000942 .
obo:SCDO_0004139 a rdfs:Class ;
rdfs:label "Adult Hemoglobin" ;
rdfs:comment "The most common and normal adult human hemoglobin tetramer, comprising over 97% of the total red blood cell hemoglobin and consisting of two alpha chains and two beta chains." ;
rdfs:subClassOf obo:SCDO_0006835 .
obo:NCIT_C16779 a rdfs:Class ;
rdfs:label "Language" ;
rdfs:comment "A systematic means of communicating by the use of sounds, symbols, or gestures." ;
rdfs:subClassOf obo:SCDO_0001551 .
obo:SCDO_0000401 a rdfs:Class ;
rdfs:label "Drug Withdrawal Syndrome AE" ;
rdfs:comment "An adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:HP_0001269 a rdfs:Class ;
rdfs:label "Hemiparesis" ;
rdfs:comment "Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0000295 a rdfs:Class ;
rdfs:label "Cost-Effectiveness of Healthcare" ;
rdfs:comment "The extent to which a health intervention can be regarded as providing value for money, based on a cost-effectiveness analysis that compares the costs and health effects of the intervention. This informs decision-makers who have to determine where to allocate limited healthcare resources." ;
rdfs:subClassOf obo:SCDO_0000495 .
obo:SCDO_1000804 a rdfs:Class ;
rdfs:label "D57.818 Other sickle-cell disorders with crisis with other specified complication" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000331 .
obo:HP_0002076 a rdfs:Class ;
rdfs:label "Migraine" ;
rdfs:comment "Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms." ;
rdfs:subClassOf obo:HP_0012638 .
obo:HP_0001714 a rdfs:Class ;
rdfs:label "Ventricular Hypertrophy" ;
rdfs:comment "Enlargement of the cardiovascular ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy." ;
rdfs:subClassOf obo:HP_0030680 .
obo:SCDO_1000259 a rdfs:Class ;
rdfs:label "Unusual Hemoglobin" ;
rdfs:comment "A hemoglobin that shows characteristics of an abnormal hemoglobin, but its inheritance does not accompany any disability." ;
rdfs:subClassOf obo:SCDO_0006921 .
obo:NCIT_C20629 a rdfs:Class ;
rdfs:label "Silent Mutation" ;
rdfs:comment "A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected." ;
rdfs:subClassOf obo:NCIT_C62200 .
obo:SCDO_1000539 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Visit Date Question" ;
rdfs:comment "The Sickle in Africa core data element that records the visit date, in the format dd/mm/yyyy." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0000822 a rdfs:Class ;
rdfs:label "Hypertension" ;
rdfs:comment "The presence of chronic increased pressure in the systemic arterial system." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_0000535 a rdfs:Class ;
rdfs:label "obsolete Hemoglobin Lepore Baltimore" ;
rdfs:comment "A variant of Hemoglobin Lepore Syndrome." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0001159 a rdfs:Class ;
rdfs:label "Tobacco Use Cessation" ;
rdfs:comment "Ending the tobacco habits of smoking, chewing, or snuff use." ;
rdfs:subClassOf obo:SCDO_0000487 .
obo:NCIT_C51775 a rdfs:Class ;
rdfs:label "Widowed" ;
rdfs:comment "Indicates a person who is no longer married because of the death of his/her spouse and has not remarried." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_0001108 a rdfs:Class ;
rdfs:label "Stigmatization" ;
rdfs:comment "An oversimplified perception or conception, especially or persons, social groups, etc." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:SCDO_0000801 a rdfs:Class ;
rdfs:label "Neurological Rehabilitation" ;
rdfs:comment "Physician-supervised programs designed to rehabilitate people with diseases, trauma, or disorders of the nervous system." ;
rdfs:subClassOf obo:SCDO_0000978 .
obo:NCIT_C43646 a rdfs:Class ;
rdfs:label "Association" ;
rdfs:comment "An association is a non-hierarchical, named relationship between a source and target concept that does not affect classification and is not inherited by child concepts during classification. Associations are bidirectional and have a stated inverse. Unlike roles, associations do not have a domain or range." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_1000767 a rdfs:Class ;
rdfs:label "Month 1 - 12" ;
rdfs:comment "An answer to a question where the answer is a month between 1 - 12, selected form a list of months." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_0000046 a rdfs:Class ;
rdfs:label "Alpha-Globin Locus" ;
rdfs:comment "A region of chromosome 16 that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. It is responsible for the creation of the alpha parts (roughly half) of the oxygen transport protein Hemoglobin." ;
rdfs:subClassOf obo:SCDO_0000456 .
obo:SCDO_0001059 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-SC" ;
rdfs:comment "One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000163 .
obo:SCDO_0000029 a rdfs:Class ;
rdfs:label "Agarose Gel Electrophoresis" ;
rdfs:comment "Electrophoresis in which agar or agarose gel is used as the diffusion medium." ;
rdfs:subClassOf obo:SCDO_0000424 .
obo:SCDO_1000043 a rdfs:Class ;
rdfs:label "Gender Identity" ;
rdfs:comment "A person's concept of self as being male and masculine or female and feminine, or ambivalent, based in part on physical characteristics, parental responses, and psychological and social pressures. It is the internal experience of gender role." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:NCIT_C20711 a rdfs:Class ;
rdfs:label "SP1 Gene" ;
rdfs:comment "This gene plays a role in transcriptional regulation and is involved in several signal transduction pathways." ;
rdfs:subClassOf obo:NCIT_C16612 .
obo:SCDO_1000095 a rdfs:Class ;
rdfs:label "Conflict of Interest" ;
rdfs:comment "A situation in which an individual or their close associates might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust.The concept refers both to actual conflict of interest and the appearance or perception of conflict." ;
rdfs:subClassOf obo:SCDO_0300005 , obo:SCDO_1000430 .
obo:UO_0000095 a rdfs:Class ;
rdfs:label "Volume Unit" ;
rdfs:comment "A unit which is a standard measure of the amount of space occupied by any substance, whether solid, liquid, or gas." ;
rdfs:subClassOf obo:UO_0000000 .
obo:NCIT_C51677 a rdfs:Class ;
rdfs:label "Liver Biopsy" ;
rdfs:comment "Removal of tissue from the liver for microscopic examination." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:SCDO_1000136 a rdfs:Class ;
rdfs:label "Borana" ;
rdfs:comment "The Borana are a branch of the populous Oromo people found in southern Ethiopia and northern Kenya." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000165 a rdfs:Class ;
rdfs:label "Bronchodilator Responsiveness" ;
rdfs:comment "The improvement of forced expiratory volume in 1 second (FEV1) after inhalation of beta2-agonists and is typically measured as the change in airflow after the administration of short-acting beta2-adrenergic agonists (SABAs)." ;
rdfs:subClassOf obo:CMO_0000094 .
obo:SCDO_0000334 a rdfs:Class ;
rdfs:label "D57.819 Other sickle-cell disorders with crisis, unspecified" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000331 .
obo:SCDO_0000016 a rdfs:Class ;
rdfs:label "Acute Complications of Sickle Cell Disease" ;
rdfs:comment "A condition that co-exists or follows from sickle cell disease and that has a severe and rapid onset of symptoms with short duration." ;
rdfs:subClassOf obo:NCIT_C2959 , obo:SCDO_0000895 .
obo:HP_0001369 a rdfs:Class ;
rdfs:label "Arthritis" ;
rdfs:comment "Inflammation of a joint." ;
rdfs:subClassOf obo:HP_0000924 .
obo:OBI_0002556 a rdfs:Class ;
rdfs:label "Minimum Age Value Specification" ;
rdfs:comment "A value specifcation that specifies the youngest age when specifying an age range." ;
rdfs:subClassOf obo:SCDO_1000401 .
obo:SCDO_0000327 a rdfs:Class ;
rdfs:label "D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000325 .
obo:SCDO_1000201 a rdfs:Class ;
rdfs:label "High Level Albuminuria" ;
rdfs:comment "An abnormal albumin excretion rate of more than 300 mg/g urine creatinine." ;
rdfs:subClassOf obo:SCDO_0000037 .
obo:SCDO_1000090 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S/S-South End" ;
rdfs:comment "A rare, reported severe, type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin S-South End." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000163 .
obo:SCDO_0000935 a rdfs:Class ;
rdfs:label "Pruritus" ;
rdfs:comment "Pruritus, or itch, is defined as an unpleasant sensation that provokes the desire to scratch." ;
rdfs:subClassOf obo:HP_0000961 .
obo:SCDO_0001230 a rdfs:Class ;
rdfs:label "Venipuncture" ;
rdfs:comment "Extraction of blood from a vein using a needle. In human, the basilic, cephalic and median cubital veins are most commonly used as well as the femoral vein." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:SCDO_1000343 a rdfs:Class ;
rdfs:label "History of Type 1 and Type 2 Diabetes" ;
rdfs:comment "A record of an individual's history of type 1 and type 2 diabetes." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:HP_0003282 a rdfs:Class ;
rdfs:label "Decreased Serum Alkaline Phosphatase" ;
rdfs:comment "Abnormally reduced serum levels of alkaline phosphatase." ;
rdfs:subClassOf obo:HP_0004379 .
obo:SCDO_0000529 a rdfs:Class ;
rdfs:label "deprecated Hemoglobin Disease Other than C,D,E,F,H,O-Arab,S" ;
rdfs:comment "A disease caused by atypical hemoglobins molecules other than hemoglobin C,D,E, F, H, O-Arab and S." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0001133 a rdfs:Class ;
rdfs:label "Symptomatic Therapeutics" ;
rdfs:comment "Therapeutics that ease the symptoms without addressing the basic cause of the disease." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:HP_0000855 a rdfs:Class ;
rdfs:label "Insulin Resistance" ;
rdfs:comment "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." ;
rdfs:subClassOf obo:HP_0011014 .
obo:SCDO_1000229 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype EE" ;
rdfs:comment "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 26 of beta-globin chains (hemoglobin E mutation) produced by both beta-globin gene (HBB) alleles." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_0300006 a rdfs:Class ;
rdfs:label "Information Disclosure" ;
rdfs:comment "Revealing of information, by oral or written communication." ;
rdfs:subClassOf obo:SCDO_0002125 .
obo:NCIT_C20197 a rdfs:Class ;
rdfs:label "Male" ;
rdfs:comment "A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:NCIT_C114717 a rdfs:Class ;
rdfs:label "Dialysis Catheter Fracture" ;
rdfs:comment "A crack or break in a dialysis catheter caused by material weakness or mechanical compression." ;
rdfs:subClassOf obo:NCIT_C78254 .
obo:SCDO_1000141 a rdfs:Class ;
rdfs:label "Bassa" ;
rdfs:comment "Bassa is a Niger-Congo Kru language. Historians have traced the Bassa's origins back to Egypt nearly six thousand years ago. Due to their migration from Egypt to other parts of Africa, the Bassa in Liberia share a similar history with Bassa groups in other parts of the continent such as Nigeria (Bassa Nge), The Democratic Republic of the Congo (Bassaa la Mpasu), Togo (Basa'r), Senegal (Bassa-Ri), and Cameroon (Basaa Mpoo)." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000121 a rdfs:Class ;
rdfs:label "Betamaribe" ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000459 a rdfs:Class ;
rdfs:label "Deferred Consent" ;
rdfs:comment "Consent that is taken later after enrollment into study especially in emergency situations." ;
rdfs:subClassOf obo:SCDO_1000457 .
obo:HP_0002715 a rdfs:Class ;
rdfs:label "Abnormality of the Immune System" ;
rdfs:comment "An abnormality of the immune system." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0000456 a rdfs:Class ;
rdfs:label "Globin Locus" ;
rdfs:comment "A genetic locus responsible for the encoding of globins." ;
rdfs:subClassOf obo:SCDO_1000103 .
obo:SCDO_0001197 a rdfs:Class ;
rdfs:label "obsolete Twin Study" ;
rdfs:comment "'Work consisting of reporting using a method of detecting genetic causes in human traits and genetic factors in behavior using sets of twins. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000941 .
obo:SCDO_1000872 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Street Question" ;
rdfs:comment "The Sickle in Africa core data element that records the name of the street in which the respondent lives." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000332 a rdfs:Class ;
rdfs:label "Executive Dysfunction" ;
rdfs:comment "A disruption to the efficacy of the executive functions, which is a group of cognitive processes that regulate, control, and manage other cognitive processes." ;
rdfs:subClassOf obo:HP_0000708 .
obo:SCDO_0000494 a rdfs:Class ;
rdfs:label "Health System" ;
rdfs:comment "A system responsible for delivering services that improve, maintain or restore the health of individuals and their communities. This includes the care provided by hospitals and family doctors, but also less visible tasks such as the prevention and control of communicable disease, health promotion, health workforce planning and improving the social, economic or environmental conditions in which people live." ;
rdfs:subClassOf obo:SCDO_0000948 .
obo:SCDO_1000886 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Blood Transfusion Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether the participant was given a blood transfusion." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000711 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Body Temperature Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's body temperature." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000417 a rdfs:Class ;
rdfs:label "Electrocardiography" ;
rdfs:comment "Recording of the moment-to-moment electromotive forces of the heart as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a cathode ray tube display." ;
rdfs:subClassOf obo:SCDO_0000500 .
obo:SCDO_0000147 a rdfs:Class ;
rdfs:label "Blood Transfusion" ;
rdfs:comment "The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)" ;
rdfs:subClassOf obo:SCDO_0000922 , obo:SCDO_0001133 .
obo:IDO_0000560 a rdfs:Class ;
rdfs:label "Antifungal" ;
rdfs:comment "A material entity bearing an antifungal disposition." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001133 .
obo:SCDO_0000882 a rdfs:Class ;
rdfs:label "Percussion of Liver" ;
rdfs:comment "A method of determining the size of the liver by tapping on the surface of the abdomen." ;
rdfs:subClassOf obo:SCDO_0000694 .
obo:SCDO_0000305 a rdfs:Class ;
rdfs:label "Current Educational Attainment" ;
rdfs:comment "The respondent's highest level of education at the current time." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0000414 , obo:SCDO_0001090 , obo:SCDO_1000157 .
obo:SCDO_0000284 a rdfs:Class ;
rdfs:label "Controlled Clinical Trials as Topic" ;
rdfs:comment "Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as randomized controlled trials as topic." ;
rdfs:subClassOf obo:SCDO_0000259 .
obo:SCDO_0000316 a rdfs:Class ;
rdfs:label "D57.2 Sickle-cell/Hb-C disease" ;
rdfs:comment "One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c. It is similar to, but less severe than sickle cell anemia." ;
rdfs:subClassOf obo:SCDO_0000311 .
obo:HP_0003394 a rdfs:Class ;
rdfs:label "Muscle Cramps" ;
rdfs:comment "Sudden and involuntary contractions of one or more muscles." ;
rdfs:subClassOf obo:SCDO_1000268 .
obo:HP_0001882 a rdfs:Class ;
rdfs:label "Leukopenia" ;
rdfs:comment "An abnormal decreased number of leukocytes in the blood." ;
rdfs:subClassOf obo:HP_0011893 .
obo:HP_0000078 a rdfs:Class ;
rdfs:label "Abnormality of the Genital System" ;
rdfs:comment "An abnormality of the genital system." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_1000813 a rdfs:Class ;
rdfs:label "Normal Arterial Oxygen Saturation" ;
rdfs:comment "When the degree to which oxygen is bound to hemoglobin in arterial blood is in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:SCDO_1000289 a rdfs:Class ;
rdfs:label "Hemoglobin D-Punjab Present" ;
rdfs:comment "When the abnormal hemoglobin, hemoglobin D-Punjab (Hb D-Punjab), has been detected in a blood sample." ;
rdfs:subClassOf obo:HP_0020061 .
obo:SCDO_1000228 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype AO-Arab" ;
rdfs:comment "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin O-Arab. Individuals with this genotype are known to be carriers of the hemoglobin O-Arab trait." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_0009089 a rdfs:Class ;
rdfs:label "Non-Maleficience" ;
rdfs:comment "Principle dictating that harm should not come to individuals as a result of their participation in a research project." ;
rdfs:subClassOf obo:GSSO_003239 .
obo:SCDO_0000287 a rdfs:Class ;
rdfs:label "Coping Strategies Questionnaire revised for Sickle Cell Disease (CSQ-SCD)" ;
rdfs:comment "The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:NCIT_C78652 a rdfs:Class ;
rdfs:label "Pediatric Quality of Life Inventory (PedsQL)" ;
rdfs:comment "A parent report or patient self report for measuring health-related quality of life (HRQOL) in healthy children and adolescents and those with acute and chronic health conditions. The PedsQL Measurement Model uses a modular approach that integrates both generic core scales and disease-specific modules into one measurement system. (Copyright 1998-2008 James W. Varni, Ph.D.)" ;
rdfs:subClassOf obo:SCDO_0000952 .
obo:NCIT_C25150 a rdfs:Class ;
rdfs:label "Age" ;
rdfs:comment "How long something has existed; elapsed time since birth." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_1000157 .
obo:SCDO_0000497 a rdfs:Class ;
rdfs:label "Healthy Diet" ;
rdfs:comment "Dietary patterns which have been found to be important in reducing disease risk." ;
rdfs:subClassOf obo:NCIT_C15900 , obo:SCDO_0000487 .
obo:HP_0000961 a rdfs:Class ;
rdfs:label "Cyanosis" ;
rdfs:comment "Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood." ;
rdfs:subClassOf obo:HP_0011121 .
obo:HP_0001896 a rdfs:Class ;
rdfs:label "Reticulocytopenia" ;
rdfs:comment "A reduced number of reticulocytes in the peripheral blood." ;
rdfs:subClassOf obo:HP_0004312 .
obo:NCIT_C120255 a rdfs:Class ;
rdfs:label "Intelligence Scale - 6 to 16 years 11 months" ;
rdfs:comment "A battery of tests that allow an investigator to conduct a comprehensive evaluation of a child or adolescent's cognitive ability." ;
rdfs:subClassOf obo:NCIT_C122920 .
obo:CMO_0002341 a rdfs:Class ;
rdfs:label "White Blood Cell Measurement" ;
rdfs:comment "Any value resulting from the quantification of a morphological or physiological parameter of leukocytes, largely colorless blood corpuscles capable of ameboid movement, whose chief function is to protect the body against microorganisms and other disease-causing entities." ;
rdfs:subClassOf obo:CMO_0000036 .
obo:NCIT_C38085 a rdfs:Class ;
rdfs:label "Pulse Oximetry" ;
rdfs:comment "A non-invasive method that provides estimates of arterial oxyhemoglobin saturation by utilizing selected wavelengths of light to determine the saturation of oxyhemoglobin." ;
rdfs:subClassOf obo:SCDO_0000942 .
obo:SCDO_0000819 a rdfs:Class ;
rdfs:label "Observational Studies as Topic" ;
rdfs:comment "Works about clinical studies in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study)." ;
rdfs:subClassOf obo:SCDO_0000253 .
obo:SCDO_0001209 a rdfs:Class ;
rdfs:label "Urine Albumin Concentration" ;
rdfs:comment "The amount of albumin in a specified volume of urine." ;
rdfs:subClassOf obo:SCDO_0001207 .
obo:SCDO_0000794 a rdfs:Class ;
rdfs:label "obsolete Nephrology" ;
rdfs:comment "'A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001208 .
obo:SCDO_0000643 a rdfs:Class ;
rdfs:label "Insect Repellents" ;
rdfs:comment "Substances causing insects to turn away from them or reject them as food." ;
rdfs:subClassOf obo:SCDO_0000709 .
obo:SCDO_1000010 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S/HPFH" ;
rdfs:comment "A group of disorders caused by large deletions of the beta-globin gene complex; typically 30% fetal haemoglobin." ;
rdfs:subClassOf obo:SCDO_1000163 , obo:SCDO_1000215 .
obo:SCDO_0000839 a rdfs:Class ;
rdfs:label "Osteomalacia" ;
rdfs:comment "A general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_0000951 a rdfs:Class ;
rdfs:label "Quality of Life and Care Measure" ;
rdfs:comment "A measurement tool that is useful in aiding routine clinical practice with regard to quality of life and/or quality of care." ;
rdfs:subClassOf obo:SCDO_0000950 .
obo:SCDO_1000704 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin O-Arab Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin O-Arab." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000766 a rdfs:Class ;
rdfs:label "obsolete Modifying the Home Environment and Making it Safer For the Patient" ;
rdfs:subClassOf obo:SCDO_1000035 .
obo:SCDO_1000802 a rdfs:Class ;
rdfs:label "D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000798 .
obo:SCDO_1000241 a rdfs:Class ;
rdfs:label "Absent Hemoglobin A" ;
rdfs:comment "A lack of production of normal adult hemoglobin." ;
rdfs:subClassOf obo:HP_0020061 , obo:SCDO_1000061 .
obo:SCDO_1000790 a rdfs:Class ;
rdfs:label "D57.42 Sickle-cell thalassemia beta zero without crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000323 .
obo:SCDO_0000057 a rdfs:Class ;
rdfs:label "Anti-Inflammatory Agent" ;
rdfs:comment "Substance that reduces or suppresses inflammation." ;
rdfs:subClassOf obo:SCDO_0000809 .
obo:SCDO_0005722 a rdfs:Class ;
rdfs:label "Genetic Structure" ;
rdfs:comment "A biological object that contains genetic information and that is involved in transmitting genetically encoded traits from one organism to another." ;
rdfs:subClassOf obo:SCDO_0000765 .
obo:SCDO_0000797 a rdfs:Class ;
rdfs:label "Nephrotic Range Proteinuria" ;
rdfs:comment "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children." ;
rdfs:subClassOf obo:SCDO_0000932 .
obo:CMO_0000366 a rdfs:Class ;
rdfs:label "Blood Differential White Blood Cell Count" ;
rdfs:comment "The number of each type of leukocyte present in a specific volume of blood, usually 1 cubic millimeter." ;
rdfs:subClassOf obo:CMO_0000027 .
obo:MP_0003224 a rdfs:Class ;
rdfs:label "Neuron Degeneration" ;
rdfs:comment "A retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_1000360 a rdfs:Class ;
rdfs:label "Globin Gene" ;
rdfs:comment "A gene that encodes one of the globin family proteins, which are globular heme-containing proteins and include androglobin, cryoglobin, hemoglobin subunits, myoglobin and neuroglobin." ;
rdfs:subClassOf obo:NCIT_C16612 .
obo:SCDO_1000080 a rdfs:Class ;
rdfs:label "deprecated Mild S/Beta-Plus-Thal" ;
rdfs:comment "'Not described [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000091 .
obo:SCDO_1000177 a rdfs:Class ;
rdfs:label "N48.32 Priapism due to disease classified elsewhere" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000607 .
obo:NCIT_C131682 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-SS" ;
rdfs:comment "A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000106 .
obo:SCDO_1000698 a rdfs:Class ;
rdfs:label "Hemoglobin A2 Level" ;
rdfs:comment "The amount of hemoglobin A2 present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:HP_0001622 a rdfs:Class ;
rdfs:label "Preterm Delivery" ;
rdfs:comment "The birth of a baby of less than 37 weeks of gestational age." ;
rdfs:subClassOf obo:HP_0001197 .
obo:SCDO_0001611 a rdfs:Class ;
rdfs:label "deprecated-Renal Insufficiency" ;
rdfs:comment "A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:CMO_0000111 a rdfs:Class ;
rdfs:label "Blood Granulocyte Count" ;
rdfs:comment "The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter." ;
rdfs:subClassOf obo:CMO_0000366 .
obo:SCDO_0000666 a rdfs:Class ;
rdfs:label "Isoelectric Focusing" ;
rdfs:comment "Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point." ;
rdfs:subClassOf obo:SCDO_0000424 , obo:SCDO_1000577 .
obo:SCDO_1000861 a rdfs:Class ;
rdfs:label "Last Name" ;
rdfs:comment "A last name (surname) is a name added to a given name and is part of a personal name and is often the family name." ;
rdfs:subClassOf obo:NCIT_C25191 .
obo:HP_0003116 a rdfs:Class ;
rdfs:label "Abnormal Echocardiogram" ;
rdfs:comment "An abnormality detectable by sonography of the heart (echocardiography)." ;
rdfs:subClassOf obo:HP_0500015 .
obo:SCDO_0000780 a rdfs:Class ;
rdfs:label "deprecated Musculoskeletal System" ;
rdfs:comment "Anatomical system that consists of the muscular and skeletal systems." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:HP_0025142 a rdfs:Class ;
rdfs:label "Constitutional Symptom" ;
rdfs:comment "A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_1000070 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/Lepore Boston" ;
rdfs:comment "A compound heterozygous genotype, involving the mutations for Hemoglobin S (beta6Glu>Val) and Hemoglobin Lepore Boston." ;
rdfs:subClassOf obo:SCDO_1000107 .
obo:SCDO_0000834 a rdfs:Class ;
rdfs:label "Ophthalmoscope" ;
rdfs:comment "Device for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_1000325 a rdfs:Class ;
rdfs:label "Former Smoker" ;
rdfs:comment "A person who was not smoking at the time of the interview but has smoked a cigarette in the past, even if just one or two puffs" ;
rdfs:subClassOf obo:SCDO_0000235 .
obo:NCIT_C48660 a rdfs:Class ;
rdfs:label "NA" ;
rdfs:comment "Determination of a value is not relevant in the current context." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:CMO_0000021 a rdfs:Class ;
rdfs:label "Body Morphological Measurement" ;
rdfs:comment "Measurement of the structure or forms of the entire body or parts of the body of an organism." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_0000360 a rdfs:Class ;
rdfs:label "Depression" ;
rdfs:comment "A common mental disorder, characterized by sadness, hopelessness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration. Depression can be long-lasting or recurrent, substantially impairing an individual's ability to function at work or school or cope with daily life." ;
rdfs:subClassOf obo:HP_0000708 , obo:SCDO_0000746 , obo:SCDO_0000954 .
obo:SCDO_1000570 a rdfs:Class ;
rdfs:label "Month of SCD Diagnosis" ;
rdfs:comment "The month when a sickle cell disease diagnosis was made." ;
rdfs:subClassOf obo:SCDO_1000569 .
obo:HP_0002955 a rdfs:Class ;
rdfs:label "Granulomatosis" ;
rdfs:comment "Any disease characterized by the formation of numerous granulomas." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:SCDO_1000253 a rdfs:Class ;
rdfs:label "Abnormal Biological Process" ;
rdfs:comment "A situation in which a specific biological process within an organism is abnormal." ;
rdfs:subClassOf obo:HP_0000118 .
obo:CMO_0000225 a rdfs:Class ;
rdfs:label "Arterial Blood Gas Measurement" ;
rdfs:comment "Any measurement of a gas or gases dissolved in arterial blood, that is, blood which has absorbed oxygen in the lungs, including oxygen, nitrogen carbon dioxide and/or hydrogen." ;
rdfs:subClassOf obo:CMO_0001321 .
obo:SCDO_0000897 a rdfs:Class ;
rdfs:label "Physical Environment" ;
rdfs:comment "The part of the human environment that consists of purely physical factors, including the natural environment (such as soil, climate, water supply) and the built environment." ;
rdfs:subClassOf obo:SCDO_0000435 .
obo:SCDO_0000396 a rdfs:Class ;
rdfs:label "Doppler Ultrasound Machine - 2 Megahertz" ;
rdfs:comment "A diagnostic ultrasound-based imaging technique operating at the frequency range of 2 megahertz. This machine makes use of the doppler effect to measure and visualise blood flow for possible pathology or lesions within blood vessels." ;
rdfs:subClassOf obo:OBI_0001098 .
obo:SCDO_0000812 a rdfs:Class ;
rdfs:label "Non-specific Acute Lower Respiratory Tract Episode" ;
rdfs:comment "Includes acute respiratory episodes with lower respiratory tract signs that do not meet the criteria for other diagnoses. May include episodes which would have been diagnosed as ACS were radiographic facilities available." ;
rdfs:subClassOf obo:HP_0002086 .
obo:SCDO_0000957 a rdfs:Class ;
rdfs:label "obsolete Questionnaire" ;
rdfs:comment "'Collection of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000034 .
obo:SCDO_1000147 a rdfs:Class ;
rdfs:label "A Parental Guide to Managing Sickle Cell Disease" ;
rdfs:comment "A booklet with information and standard guidelines to help parents learn about sickle cell disease and how to take care of their children with sickle cell disease." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_1000130 a rdfs:Class ;
rdfs:label "Peulh" ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000826 a rdfs:Class ;
rdfs:label "Normal Mean Corpuscular Hemoglobin" ;
rdfs:comment "When the average amount of hemoglobin per red blood cell (calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood) falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:SCDO_1000807 a rdfs:Class ;
rdfs:label "Increased Carboxyhemoglobin" ;
rdfs:comment "An elevated concentration in the blood of carboxyhemoglobin, which is the form of hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO)." ;
rdfs:subClassOf obo:HP_0020063 .
obo:SCDO_0000924 a rdfs:Class ;
rdfs:label "Primary Healthcare" ;
rdfs:comment "Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community." ;
rdfs:subClassOf obo:SCDO_0000494 .
obo:SCDO_0000233 a rdfs:Class ;
rdfs:label "Chronic Sickle Cell Pain" ;
rdfs:comment "Persistent pain in sickle cell disease. In sickle cell disease, persistent pain (pain that has lasted longer than 3 to 6 months) no longer serves as a warning sign. However, the time distinction is arbitrary and the condition may be difficult to distinguish from frequently recurring acute pain. Chronic pain may occur with objective signs of avascular necrosis, arthropathy, arthritis, leg ulcers or vertebral body collapse, or without objective signs, due to neuroplasticity of the peripheral nervous system." ;
rdfs:subClassOf obo:HP_0012532 , obo:SCDO_0001023 .
obo:SCDO_0000442 a rdfs:Class ;
rdfs:label "Generalised Anxiety Disorder Questionnaire (GAD-7)" ;
rdfs:comment "The GAD-7 is a self-administered patient questionnaire used as a screening tool and severity measure for generalised anxiety disorder. The GAD-7 score is calculated by assigning scores of 0, 1, 2, and 3, to the response categories of 'not at all', 'several days', 'more than half the days', and 'nearly every day', respectively, and adding together the scores for the seven questions. Scores of 5, 10, and 15 are taken as the cut-off points for mild, moderate and severe anxiety, respectively. When used as a screening tool, further evaluation is recommended when the score is 10 or greater." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_0001241 a rdfs:Class ;
rdfs:label "Wheezing Episode with Co-Morbid Asthma" ;
rdfs:comment "An acute onset of wheezing in a person with SCD and co-morbid asthma." ;
rdfs:subClassOf obo:SCDO_0000895 .
obo:SCDO_0000262 a rdfs:Class ;
rdfs:label "Cognitive Therapy" ;
rdfs:comment "A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior." ;
rdfs:subClassOf obo:SCDO_0001284 .
obo:SCDO_0000518 a rdfs:Class ;
rdfs:label "Hemoglobin Barts Hydrops Fetalis" ;
rdfs:comment "The most severe form of alpha-thalassemia and is almost always lethal, and characterized by fetal onset of generalized edema, pleural and pericardial effusions, and severe hypochromic anemia. It is caused by the presence of Hemoglobin Barts, a hemoglobin with four gamma chains, which has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues" ;
rdfs:subClassOf obo:SCDO_0000042 .
obo:SCDO_0001375 a rdfs:Class ;
rdfs:label "obsolete homozygous beta c mutation" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000127 a rdfs:Class ;
rdfs:label "Luhya" ;
rdfs:comment "The Luhya ethnic group, also known as the Abaluhya, Baluhya, or Abaluyia, is a Bantu tribe living in Kenya's agriculturally fertile western region. They are the second largest tribe in Kenya and neighbors to some of the Nilotic tribes, including the Luo, Kalenjin, Maasai and Teso (Iteso)." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:UO_0000104 a rdfs:Class ;
rdfs:label "fL" ;
rdfs:comment "A volume unit which is equal to 10^[-15] L." ;
rdfs:subClassOf obo:UO_0000095 .
obo:SCDO_0001250 a rdfs:Class ;
rdfs:label "X-Ray Image of Chest" ;
rdfs:comment "The visual output that an X-ray machine produces when imaging the chest." ;
rdfs:subClassOf obo:SCDO_0001249 .
obo:SCDO_1000763 a rdfs:Class ;
rdfs:label "Type of Body Temperature" ;
rdfs:subClassOf obo:SCDO_1000576 .
obo:SCDO_0001054 a rdfs:Class ;
rdfs:label "Sickle Cell Related Cancer" ;
rdfs:comment "A cancer that is almost exclusively associated with sickle cell trait and/or sickle cell disease." ;
rdfs:subClassOf obo:OBI_1110053 .
obo:SCDO_0000338 a rdfs:Class ;
rdfs:label "obsolete Protein Molecule" ;
rdfs:comment "'Protein molecule are large, complex molecules that play many critical roles in the body. They do most of the work in cells and are required for the structure, function, and regulation of the body's tissues and organs. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000117 a rdfs:Class ;
rdfs:label "Beta-Globin Haplotype" ;
rdfs:comment "Defined arrays of polymorphic gene sites that are inherited together across the genetic vicinity of the beta-globin gene or gene cluster on chromosome 11." ;
rdfs:subClassOf obo:NCIT_C63547 .
obo:NCIT_C3890 a rdfs:Class ;
rdfs:label "Hypoxia" ;
rdfs:comment "A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). In SCD patients, this is considered as saturated oxygen < 95% on air." ;
rdfs:subClassOf obo:HP_0002086 .
obo:SCDO_1000841 a rdfs:Class ;
rdfs:label "Increased Partial Pressure of Carbon Dioxide" ;
rdfs:comment "An abnormal increase in the pressure exerted by carbon dioxide dissolved in the blood." ;
rdfs:subClassOf obo:MP_0002329 .
obo:HP_0000388 a rdfs:Class ;
rdfs:label "Otitis Media" ;
rdfs:comment "Inflammation or infection of the middle ear." ;
rdfs:subClassOf obo:HP_0002715 , obo:IDO_0000586 .
obo:SCDO_0001073 a rdfs:Class ;
rdfs:label "Skin Rash" ;
rdfs:comment "An abnormal change in skin color, appearance, or texture." ;
rdfs:subClassOf obo:HP_0011122 .
obo:SCDO_1000234 a rdfs:Class ;
rdfs:label "obsolete - Hemoglobin M trait Genotype" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000087 a rdfs:Class ;
rdfs:label "HBB, LYS132ASN" ;
rdfs:comment "A mutation where the lysine residue in position 132 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation on its own produces Hb Yamagata which has reduced oxygen affinity, but no distinctive clinical abnormalities. However, when present in the same gene as the Hb S mutation (HBB, GLU6VAL), the sickling HbS-South End is produced." ;
rdfs:subClassOf obo:SCDO_0009786 .
obo:SCDO_0000383 a rdfs:Class ;
rdfs:label "obsolete Diffusion Capacity by Biochemical Methods" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0011886 a rdfs:Class ;
rdfs:label "Hyphema" ;
rdfs:comment "Bleeding in the anterior chamber of the eye." ;
rdfs:subClassOf obo:HP_0000478 , obo:HP_0011025 , obo:NCIT_C115319 .
obo:SCDO_0001342 a rdfs:Class ;
rdfs:label "Gene-Environment Interaction" ;
rdfs:comment "Combined effects of genotypes and environmental factors together to affect phenotypic characteristics." ;
rdfs:subClassOf obo:SCDO_0000391 .
obo:SCDO_0000251 a rdfs:Class ;
rdfs:label "Clinical Phenotype of Beta Thalassemia" ;
rdfs:comment "Abnormal clinical manifestations of beta thalassemia that are as a result of the underlying genotype." ;
rdfs:subClassOf obo:SCDO_0000111 .
obo:SCDO_0000699 a rdfs:Class ;
rdfs:label "Longitudinal Studies" ;
rdfs:comment "Studies in which variables relating to an individual or group of individuals are assessed over a period of time." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:HP_0000707 a rdfs:Class ;
rdfs:label "Abnormality of the Nervous System" ;
rdfs:comment "Any abnormality of the nervous system." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0000818 a rdfs:Class ;
rdfs:label "obsolete Observational Study" ;
rdfs:comment "'A work that reports on the results of a clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study). [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000252 .
obo:SCDO_0000128 a rdfs:Class ;
rdfs:label "Birthplace of Maternal Grandmother" ;
rdfs:comment "The country in which the respondent's biological maternal (on the mother's side of the family) grandmother was born." ;
rdfs:subClassOf obo:SCDO_0000126 .
obo:SCDO_0000979 a rdfs:Class ;
rdfs:label "Reincarnation" ;
rdfs:comment "Reincarnation is the philosophical or religious concept that an aspect of a living being starts a new life in a different physical body or form after each biological death." ;
rdfs:subClassOf obo:SCDO_0000107 .
obo:HP_0001061 a rdfs:Class ;
rdfs:label "Acne" ;
rdfs:comment "A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts)." ;
rdfs:subClassOf obo:HP_0011123 .
obo:NCIT_C16723 a rdfs:Class ;
rdfs:label "Immunological Assay" ;
rdfs:comment "Laboratory test involving interaction of antigens with specific antibodies." ;
rdfs:subClassOf obo:SCDO_0000120 .
obo:SCDO_0001092 a rdfs:Class ;
rdfs:label "Solubility Test" ;
rdfs:comment "A basic first line test that looks for the presence of abnormal Hemoglobin S in a blood sample. Sodium metabisulfite is added to the blood sample which causes Hb S polymerisation and sickling of red blood cells if Hb S is present. A positive result means that a person has either Sickle Cell Disease or Sickle Cell Trait. Confirmatory tests are needed to distinguish which form of SCD the patient has." ;
rdfs:subClassOf obo:SCDO_0000548 , obo:SCDO_1000577 .
obo:SCDO_0000236 a rdfs:Class ;
rdfs:label "Climate" ;
rdfs:comment "Meteorological conditions, including temperature, precipitation, and wind, that characteristically prevail in a particular region; includes regions of the earth having particular meteorological conditions." ;
rdfs:subClassOf obo:SCDO_0000897 .
obo:SCDO_0000789 a rdfs:Class ;
rdfs:label "Naloxone" ;
rdfs:comment "A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors." ;
rdfs:subClassOf obo:CHEBI_35482 .
obo:SCDO_1000152 a rdfs:Class ;
rdfs:label "Evidence-Based Management of Sickle Cell Disease" ;
rdfs:comment "Guidelines providing the best science-based recommendations to guide practice decisions for primary care providers and other clinicians, nurses, and staff who provide emergency or continuity care to individuals with sickle cell disease (SCD). They assist health care professionals in the management of common issues, including routine health maintenance, the recognition and treatment of common acute and chronic complications and comorbidities of SCD, as well as the indications for and monitoring of hydroxyurea and blood transfusion therapy. The guidelines address the care of infants, children, adolescents, and adults with SCD, with the goal of facilitating high-quality and appropriate care for all individuals with this disease." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_0000902 a rdfs:Class ;
rdfs:label "Physiological Assay" ;
rdfs:comment "An organismal assay designed to capture information pertaining to the organic processes and phenomena of an organism or any of its parts or of a particular bodily process." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:NCIT_C107564 a rdfs:Class ;
rdfs:label "S-Nitroso-Hemoglobin" ;
rdfs:comment "Hemoglobin that has a nitric oxide bound to the cysteine at position 93 in the beta-globin chain." ;
rdfs:subClassOf obo:NCIT_C16676 .
obo:SCDO_0000301 a rdfs:Class ;
rdfs:label "Curative Therapeutics" ;
rdfs:comment "Therapeutics relating to or used in the cure of diseases." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:HP_0002170 a rdfs:Class ;
rdfs:label "Intracranial Hemorrhage" ;
rdfs:comment "Hemorrhage occurring within the skull." ;
rdfs:subClassOf obo:SCDO_1000037 .
obo:SCDO_1000099 a rdfs:Class ;
rdfs:label "Modifier Gene" ;
rdfs:comment "Genes with alleles that affect the phenotype associated with a nonallelic gene." ;
rdfs:subClassOf obo:SCDO_0000444 .
obo:SCDO_1000239 a rdfs:Class ;
rdfs:label "Heterozygous Deletion of HBA1 or HBA2" ;
rdfs:comment "Deletion of one alpha-globin gene, either an HBA1 or HBA2 gene, which results in Alpha Thalassemia Silent (the person with the mutation is a silent carrier)." ;
rdfs:subClassOf obo:SCDO_0001386 .
obo:SCDO_0001047 a rdfs:Class ;
rdfs:label "Sickle Cell Disease Health-Related Stigma Scale (SCD-HRSS)" ;
rdfs:comment "A measure of stigma among adults living with Sickle Cell disease. Focus on; depressive symptoms, pain, assertive communication, satisfaction with pain management experience, and health-related stigma." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:SCDO_0000420 a rdfs:Class ;
rdfs:label "Electroencephalography" ;
rdfs:comment "Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain." ;
rdfs:subClassOf obo:SCDO_0000208 .
obo:MP_0011469 a rdfs:Class ;
rdfs:label "Abnormal Urine Creatinine Level" ;
rdfs:comment "Any change in the amount of creatinine in the urine" ;
rdfs:subClassOf obo:MP_0011468 .
obo:NCIT_C142664 a rdfs:Class ;
rdfs:label "Recruitment Period" ;
rdfs:comment "The interval of time during which subjects are to be enrolled in a clinical study." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_1000350 a rdfs:Class ;
rdfs:label "Heart Valve Function Test" ;
rdfs:comment "A test to assess the structure and function of the heart valves." ;
rdfs:subClassOf obo:SCDO_0000500 .
obo:OGMS_0000028 a rdfs:Class ;
rdfs:label "Disease Phenotype" ;
rdfs:comment "A clinically abnormal phenotype that is characteristic of a single disease." ;
rdfs:subClassOf obo:OGMS_0000023 .
obo:NCIT_C115319 a rdfs:Class ;
rdfs:label "Ophthalmologic Complication" ;
rdfs:comment "Any eye disorder occurring as a consequence of injury to the eye." ;
rdfs:subClassOf obo:NCIT_C2959 .
obo:NCIT_C99063 a rdfs:Class ;
rdfs:label "Spinal Cord Infarction" ;
rdfs:comment "Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_0000042 a rdfs:Class ;
rdfs:label "Alpha Thalassemia" ;
rdfs:comment "A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted. A hemoglobinopathy with two clinically significant forms: hemoglobin Bart hydrops fetalis (deletion of all 4 alpha-globin genes; --/--) which is severe and often results in neonatal death; and hemoglobin H disease (most commonly caused by deletion of 3 alpha-globin genes; --/-alpha) which results in hemolytic anemia, splenomegaly and bone changes." ;
rdfs:subClassOf obo:NCIT_C35069 , obo:OGMS_0000051 .
obo:SCDO_1000398 a rdfs:Class ;
rdfs:label "BCL11A Erythroid Enhancer" ;
rdfs:subClassOf obo:SCDO_1000396 .
obo:HP_0001874 a rdfs:Class ;
rdfs:label "Abnormality of Neutrophils" ;
rdfs:comment "A neutrophil abnormality." ;
rdfs:subClassOf obo:HP_0001871 .
obo:SCDO_1000700 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin D-Punjab Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin D-Punjab." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000040 a rdfs:Class ;
rdfs:label "HBB, GLU121LYS" ;
rdfs:comment "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation is found as a single alteration in Hemoglobin O-Arab and is one of the two contributing mutations to the production of Hemoglobin S-Oman." ;
rdfs:subClassOf obo:SCDO_0009786 .
obo:SCDO_1000488 a rdfs:Class ;
rdfs:label "deprecated Notes Box Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:SCDO_1000494 a rdfs:Class ;
rdfs:label "Dichotomous Question" ;
rdfs:comment "A close-ended question that provides two possible answers." ;
rdfs:subClassOf obo:SCDO_1000492 .
obo:SCDO_1000376 a rdfs:Class ;
rdfs:label "Osteonecrosis of the Humeral Head" ;
rdfs:comment "In situ death of bone within the humeral head due to disruption of blood supply." ;
rdfs:subClassOf obo:HP_0010885 .
obo:UO_0000051 a rdfs:Class ;
rdfs:label "Concentration Unit" ;
rdfs:comment "A unit which represents a standard measurement of how much of a given substance there is mixed with another substance." ;
rdfs:subClassOf obo:UO_0000000 .
obo:HP_0006689 a rdfs:Class ;
rdfs:label "Bacterial Endocarditis" ;
rdfs:comment "A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves." ;
rdfs:subClassOf obo:NCIT_C2890 .
obo:SCDO_1000723 a rdfs:Class ;
rdfs:label "Partial Pressure of Oxygen" ;
rdfs:comment "The pressure exerted by oxygen dissolved in the blood, indicating how well oxygen is able to move from the airspace of the lungs into the blood." ;
rdfs:subClassOf obo:CMO_0000225 .
obo:SCDO_1000901 a rdfs:Class ;
rdfs:label "Follow-Up Visit" ;
rdfs:comment "A clinical visit that is a follow-up for a previous visit." ;
rdfs:subClassOf obo:NCIT_C103165 .
obo:SCDO_1000244 a rdfs:Class ;
rdfs:label "Sickle Cell Trait with a Severe Pyruvate Kinase Deficiency" ;
rdfs:comment "A sickle cell disease phenotype in which an individual heterozygous for hemoglobin S also has a severe pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling." ;
rdfs:subClassOf obo:SCDO_1000211 .
obo:SCDO_1000402 a rdfs:Class ;
rdfs:label "Journal Article" ;
rdfs:comment "The predominant publication type for articles and other items indexed for NLM databases." ;
rdfs:subClassOf obo:SCDO_0300003 .
obo:SCDO_0002106 a rdfs:Class ;
rdfs:label "Splenic Infarction" ;
rdfs:comment "Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis." ;
rdfs:subClassOf obo:HP_0001743 .
obo:SCDO_0000081 a rdfs:Class ;
rdfs:label "ASCQ-Me - Quality of Care in SCD" ;
rdfs:comment "A set of 27 questions administered to adults with sickle cell disease (SCD) to determine the quality of care that they have received from health care providers." ;
rdfs:subClassOf obo:SCDO_0000947 .
obo:SCDO_0000035 a rdfs:Class ;
rdfs:label "Alanine Aminotransferase Level" ;
rdfs:comment "The amount of alanine aminotransferase present in a specified volume of blood." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_0001205 a rdfs:Class ;
rdfs:label "Urinary Albumin Test" ;
rdfs:comment "A bioassay to measure urine concentration of albumin, which is produced by the liver and is the most abundant protein in the blood." ;
rdfs:subClassOf obo:NCIT_C17241 , obo:SCDO_0000676 .
obo:SCDO_0000053 a rdfs:Class ;
rdfs:label "Anesthetic Complication AE" ;
rdfs:comment "An adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:NCIT_C35152 a rdfs:Class ;
rdfs:label "Acute Cholecystitis" ;
rdfs:comment "Acute inflammation of the gallbladder." ;
rdfs:subClassOf obo:NCIT_C34465 , obo:SCDO_1000000 .
obo:SCDO_0000222 a rdfs:Class ;
rdfs:label "Cholecystectomy" ;
rdfs:comment "Surgical removal of the gallbladder." ;
rdfs:subClassOf obo:SCDO_0001129 .
obo:NCIT_C70817 a rdfs:Class ;
rdfs:label "Study Protocol" ;
rdfs:comment "The formal plan of an experiment or research activity, including the objective, rationale, design, materials and methods for the conduct of the study; intervention description, and method of data analysis." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:NCIT_C17049 a rdfs:Class ;
rdfs:label "Race" ;
rdfs:comment "An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_1000157 .
obo:NCIT_C67015 a rdfs:Class ;
rdfs:label "mg/dL" ;
rdfs:comment "A unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters." ;
rdfs:subClassOf obo:UO_0000180 .
obo:SCDO_1000513 a rdfs:Class ;
rdfs:label "Informed Consent Obtained" ;
rdfs:comment "An indication of whether informed consent was obtained from the respondent and/or their proxy." ;
rdfs:subClassOf obo:SCDO_1000490 .
obo:NCIT_C71754 a rdfs:Class ;
rdfs:label "Anonymous" ;
rdfs:comment "Having no known name or identity or known source." ;
rdfs:subClassOf obo:SCDO_0002125 .
obo:SCDO_0005927 a rdfs:Class ;
rdfs:label "Justice" ;
rdfs:comment "An ethical principle that obligates one to treat people fairly. Distributive justice refers to allocating benefits and harms fairly; procedural justice refers to using fair processes to make decisions that affect people; formal justice refers to treating similar cases in the same way. In human subjects research, the principle of justice implies that subjects should be selected equitably." ;
rdfs:subClassOf obo:GSSO_003239 .
obo:SCDO_0000808 a rdfs:Class ;
rdfs:label "Nocturia" ;
rdfs:comment "Frequent urination at night that interrupts sleep. It is often associated with outflow obstruction, diabetes mellitus, or bladder inflammation (cystitis)." ;
rdfs:subClassOf obo:HP_0000079 .
obo:SCDO_1000730 a rdfs:Class ;
rdfs:label "Site Participant Number" ;
rdfs:comment "A site-specific unique identifier assigned to a study participant by the data collectors at the data collection site." ;
rdfs:subClassOf obo:NCIT_C69256 .
obo:HP_0000967 a rdfs:Class ;
rdfs:label "Petechiae" ;
rdfs:comment "Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae." ;
rdfs:subClassOf obo:HP_0002597 .
obo:SCDO_0000312 a rdfs:Class ;
rdfs:label "D57.0 Hb-SS disease with crisis" ;
rdfs:comment "Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis." ;
rdfs:subClassOf obo:SCDO_0000311 .
obo:SCDO_0002798 a rdfs:Class ;
rdfs:label "Pharmacogenomic Variants" ;
rdfs:comment "Naturally occurring genetic variations associated with drug response. While these variants are not markers for genetic predisposition to disease, they influence pharmacokinetics and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., angiotensin converting enzyme; cytochrome P-450 CYP2D6)." ;
rdfs:subClassOf obo:NCIT_C17004 .
obo:HP_0025546 a rdfs:Class ;
rdfs:label "Abnormal Mean Corpuscular Hemoglobin Concentration" ;
rdfs:comment "Deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." ;
rdfs:subClassOf obo:HP_0001877 .
obo:SCDO_0000913 a rdfs:Class ;
rdfs:label "Polymerase Chain Reaction" ;
rdfs:comment "The process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As the process progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified." ;
rdfs:subClassOf obo:SCDO_0000448 .
obo:SCDO_0000431 a rdfs:Class ;
rdfs:label "deprecated Endocrine and Metabolic" ;
rdfs:comment "The system pertaining to the stomach, intestines, and associated organs including liver, gallbladder, and pancreas." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0000024 a rdfs:Class ;
rdfs:label "deprecated-Adherence" ;
rdfs:comment "The extent to which a person's behaviour - taking medications, following a diet and/or executing life style changes, corresponds to agreed recommendations by a health care provider." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000291 a rdfs:Class ;
rdfs:label "Corticosteroid-Induced Adverse Event" ;
rdfs:comment "A causal adverse drug event that is induced by a corticosteroid." ;
rdfs:subClassOf obo:SCDO_0000191 .
obo:MP_0002412 a rdfs:Class ;
rdfs:label "Increased Susceptibility to Bacterial Infection" ;
rdfs:comment "Greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria." ;
rdfs:subClassOf obo:HP_0002715 .
obo:SCDO_0001123 a rdfs:Class ;
rdfs:label "Support Group" ;
rdfs:comment "Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs." ;
rdfs:subClassOf obo:SCDO_0001083 .
obo:SCDO_0000507 a rdfs:Class ;
rdfs:label "deprecated Hematopoietic System" ;
rdfs:comment "The blood-making organs and tissues, principally the bone marrow and lymph nodes." ;
rdfs:subClassOf obo:SCDO_0000511 .
obo:DOID_2326 a rdfs:Class ;
rdfs:label "Gastroenteritis" ;
rdfs:comment "A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:SCDO_1000100 a rdfs:Class ;
rdfs:label "ICD-10-CM Code Type" ;
rdfs:comment "The type of ICD-10-CM code, in terms of a code's usability for reimbursement purposes." ;
rdfs:subClassOf obo:SCDO_0000245 .
obo:SCDO_0001246 a rdfs:Class ;
rdfs:label "Witchcraft" ;
rdfs:comment "An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3rd Ed)." ;
rdfs:subClassOf obo:SCDO_0000107 .
obo:SCDO_0000777 a rdfs:Class ;
rdfs:label "Muscle Atrophy" ;
rdfs:comment "The presence of skeletal muscular atrophy, reduction in the muscle bulk." ;
rdfs:subClassOf obo:SCDO_1000268 .
obo:ICO_0000036 a rdfs:Class ;
rdfs:label "Date of Signing Consent" ;
rdfs:comment "A date specification that designates when an informed consent form was signed." ;
rdfs:subClassOf obo:SCDO_1000522 .
obo:SCDO_0000139 a rdfs:Class ;
rdfs:label "Blood Culture" ;
rdfs:comment "Test to determine the presence of blood infection (e.g. sepsis; bacteremia)." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:NCIT_C25464 a rdfs:Class ;
rdfs:label "deprecated Country" ;
rdfs:comment "A collective generic term that refers here to a wide variety of dependencies, areas of special sovereignty, uninhabited islands, and other entities in addition to the traditional countries or independent states." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:NCIT_C3833 a rdfs:Class ;
rdfs:label "Asymptomatic" ;
rdfs:comment "Without clinical signs or indications that raise the possibility of a particular disorder or dysfunction." ;
rdfs:subClassOf obo:OGMS_0000023 .
obo:SCDO_0001112 a rdfs:Class ;
rdfs:label "Stroke Impact Measure" ;
rdfs:comment "This measure is a physical assessment to determine neurological deficits due to a stroke." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_0006835 a rdfs:Class ;
rdfs:label "Normal Hemoglobin" ;
rdfs:comment "Hemoglobin that presents no inherited health condition phenotype." ;
rdfs:subClassOf obo:NCIT_C16676 , obo:SCDO_0009613 .
obo:NCIT_C25299 a rdfs:Class ;
rdfs:label "Diastolic Blood Pressure" ;
rdfs:comment "The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling." ;
rdfs:subClassOf obo:CMO_0000003 .
obo:SCDO_0003742 a rdfs:Class ;
rdfs:label "Splenectomy" ;
rdfs:comment "Surgical procedure involving either partial or entire removal of the spleen." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:HP_0032224 a rdfs:Class ;
rdfs:label "ABO Blood Group" ;
rdfs:comment "The ABO histo-blood group consists of two antigens (A and B antigens) and four blood types (types A, B, AB, and O). The A and B antigens are the product of the ABO gene and are autosomal codominant. The group O phenotype is an autosomal-recessive phenotype due to the homozygous inheritance of two null ABO alleles. Group O individuals express the H antigen, the biosynthetic precursor to A and B antigens. ABO, therefore, is the blood type, whereas A, B, and H refer to the antigens. The ABO system consists of A and B antigens and antibodies against these antigens." ;
rdfs:subClassOf obo:SCDO_0009884 .
obo:SCDO_1000502 a rdfs:Class ;
rdfs:label "Open-Ended Question - Free Text" ;
rdfs:comment "A open ended question that allows the respondent to respond in free text, without any restrictions on the nature of the text answer provided." ;
rdfs:subClassOf obo:SCDO_1000493 .
obo:NCIT_C561 a rdfs:Class ;
rdfs:label "Ibuprofen" ;
rdfs:comment "A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation." ;
rdfs:subClassOf obo:CHEBI_35475 , obo:CHEBI_35493 .
obo:SCDO_0000225 a rdfs:Class ;
rdfs:label "Chronic Complications of Sickle Cell Disease" ;
rdfs:comment "A condition that co-exists or follows from sickle cell disease and that has a slow, creeping onset, slow progress and long continuance of disease manifestations." ;
rdfs:subClassOf obo:NCIT_C2959 , obo:SCDO_0000895 .
obo:NCIT_C80411 a rdfs:Class ;
rdfs:label "Right Heart Catheterization" ;
rdfs:comment "A diagnostic procedure in which a catheter is guided into the right heart, where pressures may be measured and radiocontrast material may be injected to visualize blood flow in and around the right heart." ;
rdfs:subClassOf obo:SCDO_0000500 .
obo:SCDO_0000106 a rdfs:Class ;
rdfs:label "Behaviour" ;
rdfs:comment "The actions or reactions of a person in response to a situation or stimuli." ;
rdfs:subClassOf obo:SCDO_0000746 .
obo:SCDO_1000729 a rdfs:Class ;
rdfs:label "Increased Methemoglobin" ;
rdfs:comment "An elevated concentration in the blood of methemoglobin, which is the ferric (Fe(3+)) form of hemoglobin." ;
rdfs:subClassOf obo:HP_0020063 .
obo:SCDO_1000163 a rdfs:Class ;
rdfs:label "Compound Heterozygous Sickle Cell Disease" ;
rdfs:comment "A hemoglobinopathy in which the sickle mutation (HBB, Glu6Val) is inherited in combination with another beta-globin gene mutation, other thanHBB, Glu6Val." ;
rdfs:subClassOf obo:SCDO_0001051 .
obo:SCDO_1000256 a rdfs:Class ;
rdfs:label "Sickle Cell Acute Painful Episode - Management of an Acute Painful Sickle Cell Episode in Hospital" ;
rdfs:comment "This guideline addresses the management of an acute painful sickle cell episode in patients presenting to hospital until discharge. This includes the use of pharmacological and non-pharmacological interventions, identifying the signs and symptoms of acute complications, skills and settings for managing an acute painful episode, and the information and support needs of patients." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_0001215 a rdfs:Class ;
rdfs:label "Urine Protein Sulfosalicylic Acid Precipitation Test" ;
rdfs:comment "A method in which sulfosalicylic acid (that is, the SSA reagent) is added to a small and equal volume of clear urine. The acidification causes precipitation of protein in the sample (seen as increasing turbidity), which can be subjectively quantitated visually or more precisely quantitated using photometry." ;
rdfs:subClassOf obo:SCDO_0000120 .
obo:SCDO_0001065 a rdfs:Class ;
rdfs:label "obsolete Sickle Cell-Hemoglobin Other than A,C,D,E,O-Arab" ;
rdfs:comment "'A variant of sickle cell disease in which individuals have atypical hemoglobin molecules called hemoglobin S together with another form of abnormal hemoglobin, other than hemoglobin C,D,E and O-Arab. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0000513 a rdfs:Class ;
rdfs:label "Hemoglobin C" ;
rdfs:comment "A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_0003807 .
obo:NCIT_C34465 a rdfs:Class ;
rdfs:label "Cholecystitis" ;
rdfs:comment "An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones." ;
rdfs:subClassOf obo:HP_0025031 .
obo:HP_0001022 a rdfs:Class ;
rdfs:label "Albinism" ;
rdfs:comment "An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina)." ;
rdfs:subClassOf obo:HP_0001010 .
obo:HP_0000798 a rdfs:Class ;
rdfs:label "Oligospermia" ;
rdfs:comment "Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen." ;
rdfs:subClassOf obo:HP_0000080 .
obo:SCDO_0001386 a rdfs:Class ;
rdfs:label "Alpha-Globin Locus Deletion" ;
rdfs:comment "A deletion in or of the HBA1 or HBA2 gene that can result in some form of alpha thalassemia." ;
rdfs:subClassOf obo:NCIT_C19296 .
obo:IDOMAL_0000592 a rdfs:Class ;
rdfs:label "Spleen Examination" ;
rdfs:comment "Any process carried out to determine the condition of a patient's spleen." ;
rdfs:subClassOf obo:SCDO_0000898 .
obo:NCIT_C29091 a rdfs:Class ;
rdfs:label "Hepatitis B Vaccine" ;
rdfs:comment "A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection." ;
rdfs:subClassOf obo:VO_0000001 .
obo:SCDO_0000807 a rdfs:Class ;
rdfs:label "No-Show Patient" ;
rdfs:comment "Patients who do not turn up for scheduled healthcare appointments." ;
rdfs:subClassOf obo:SCDO_0000869 .
obo:HP_0001953 a rdfs:Class ;
rdfs:label "Diabetic Ketoacidosis" ;
rdfs:comment "A type of diabetic metabolic abnormality with an accumulation of ketone bodies." ;
rdfs:subClassOf obo:HP_0000819 .
obo:SCDO_0004888 a rdfs:Class ;
rdfs:label "Functional Hyposplenism" ;
rdfs:comment "An acquired disorder caused by several hematological and immunological diseases and characterized by impairment of splenic function." ;
rdfs:subClassOf obo:HP_0001743 .
obo:SCDO_0001320 a rdfs:Class ;
rdfs:label "Feasibility Studies" ;
rdfs:comment "Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project." ;
rdfs:subClassOf obo:SCDO_0300004 .
obo:HP_0030058 a rdfs:Class ;
rdfs:label "Sickled Erythrocyte" ;
rdfs:comment "An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains)." ;
rdfs:subClassOf obo:HP_0004447 .
obo:MP_0005533 a rdfs:Class ;
rdfs:label "Increased Body Temperature" ;
rdfs:comment "Greater than the level of heat natural to a living being." ;
rdfs:subClassOf obo:MP_0005535 .
obo:SCDO_0001019 a rdfs:Class ;
rdfs:label "Salmon Patch Hemorrhage" ;
rdfs:comment "Round or oval-shaped intraretinal accumulation of erythrocytes that may be up to 2 mm in diameter. This small intraretinal hematoma is initially red and becomes salmon colored with time." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:SCDO_1000406 a rdfs:Class ;
rdfs:label "Data Sharing Descriptor" ;
rdfs:comment "A characteristic or directive that further describes the nature of data sharing." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:SCDO_1000159 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/Beta Minus Thalassaemia" ;
rdfs:comment "When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a mutation that reduces the amount of beta-globin chain synthesised." ;
rdfs:subClassOf obo:SCDO_1000107 .
obo:NCIT_C25474 a rdfs:Class ;
rdfs:label "Data" ;
rdfs:comment "A collection or single item of factual or reported information, derived from measurement or research, from which conclusions may be drawn." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_1000799 a rdfs:Class ;
rdfs:label "D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000798 .
obo:SCDO_0001150 a rdfs:Class ;
rdfs:label "Therapeutic Device" ;
rdfs:comment "A medical device used to prevent and treat medical conditions, or to alleviate pain or injury." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:HP_0001260 a rdfs:Class ;
rdfs:label "Dysarthria" ;
rdfs:comment "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0000709 a rdfs:Class ;
rdfs:label "Malaria Prophylaxis" ;
rdfs:comment "The use of drugs or other agents to prevent malarial infection. Examples: Proguanil, mefloquine, artesunate, insect repellant, insecticide-treated-bednet." ;
rdfs:subClassOf obo:SCDO_0000930 .
obo:SCDO_0008925 a rdfs:Class ;
rdfs:label "Autonomy" ;
rdfs:comment "The capacity for self-governance, i.e. the ability to make reasonable decisions." ;
rdfs:subClassOf obo:GSSO_003239 .
obo:SCDO_1000574 a rdfs:Class ;
rdfs:label "SCD Test Result" ;
rdfs:comment "The result of a medical investigation to identify the type of sickle cell disease that a person has." ;
rdfs:subClassOf obo:CMO_0000508 , obo:SCDO_1000572 .
obo:SCDO_0000079 a rdfs:Class ;
rdfs:label "Aspartate Aminotransferase Blood Test" ;
rdfs:comment "A bioassay to measure levels of aspartate aminotransferase (AST), which is released into the blood following tissue damage." ;
rdfs:subClassOf obo:NCIT_C74954 , obo:SCDO_0000133 , obo:SCDO_0000500 .
obo:SCDO_0001010 a rdfs:Class ;
rdfs:label "Retrospective Studies" ;
rdfs:comment "Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons." ;
rdfs:subClassOf obo:SCDO_0000263 .
obo:UO_0000109 a rdfs:Class ;
rdfs:label "Pressure Unit" ;
rdfs:comment "A unit which is a standard measure of the force applied to a given area." ;
rdfs:subClassOf obo:UO_0000000 .
obo:NCIT_C75583 a rdfs:Class ;
rdfs:label "Slit-Lamp Examination" ;
rdfs:comment "Examination of the anterior segment of the eye using a medical instrument called a slit lamp." ;
rdfs:subClassOf obo:NCIT_C38060 .
obo:SCDO_0000552 a rdfs:Class ;
rdfs:label "Hemoglobinopathy" ;
rdfs:comment "An inherited disorder of the structure and/or synthesis of hemoglobin, with a variable phenotype expression ranging from benign to severe." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_0000987 a rdfs:Class ;
rdfs:label "Reproductive History Diagnostic Instrument" ;
rdfs:comment "A questionnaire to assess either male or females' pregnancy history. Females are asked about the number of pregnancies, description of pregnancies and smoking during pregnancy. Males are asked whether they have ever fathered a pregnancy and, if so, the description of the pregnancy." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_0000423 a rdfs:Class ;
rdfs:label "Electronic Health Records" ;
rdfs:comment "Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient." ;
rdfs:subClassOf obo:SCDO_0000492 .
obo:SCDO_1000235 a rdfs:Class ;
rdfs:label "Hereditary Persistence of Fetal Hemoglobin Genotype" ;
rdfs:comment "Either homozygosity or heterozygosity for the HPFH1 mutation, a 106-KB deletion in the beta globin gene cluster." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_1000896 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Anaemia Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether a participant has anaemia." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:OBI_0400169 a rdfs:Class ;
rdfs:label "Microscope" ;
rdfs:comment "A microscope is an instrument which magnifies the view on objects (too small to be viewed by the naked eye) under increased resolution. A microscope can be an optical instrument but also and electronic instrument. There are various kind of optical microscopes, e.g confocal microscope, epifluoresence microscope)." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_0001043 a rdfs:Class ;
rdfs:label "Serum HDL Cholesterol Level" ;
rdfs:comment "The amount of the HDL cholesterol, the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion, in a specified volume of serum." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_1000116 a rdfs:Class ;
rdfs:label "Adja" ;
rdfs:comment "The Adja ethnic group are mostly farmers and live in the southern part of Benin Republic. They make up 15% of the general country population. This group of people migrated into Benin between the 12th and 13th centuries from River Mono. The primary language is Aja-Gbe with a majority of the people being trilingual." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0001000 a rdfs:Class ;
rdfs:label "SCDO" ;
rdfs:comment "Root of all terms in the Sickle Cell Disease Ontology, an effort of unambiguously describing all concepts and unifying up-to-date knowledge in sickle cell disease." .
obo:MP_0001589 a rdfs:Class ;
rdfs:label "Abnormal Mean Corpuscular Hemoglobin" ;
rdfs:comment "Anomalies in the average levels of hemoglobin contained in an erythrocyte." ;
rdfs:subClassOf obo:HP_0001877 .
obo:HP_0001271 a rdfs:Class ;
rdfs:label "Polyneuropathy" ;
rdfs:comment "A generalized disorder of peripheral nerves." ;
rdfs:subClassOf obo:HP_0009830 .
obo:SCDO_1000596 a rdfs:Class ;
rdfs:label "Penicillin V Prophylaxis Use Status" ;
rdfs:comment "An indication of whether the respondent is using penicillin V prophylaxis." ;
rdfs:subClassOf obo:SCDO_1000318 , obo:SCDO_1000590 .
obo:NCIT_C26702 a rdfs:Class ;
rdfs:label "Ataxia" ;
rdfs:comment "Lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Causes include peripheral nerve disorders, posterior column injuries, cerebral and cerebellar disorders, basal ganglia disorders, and thalamic disorders." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_1000354 a rdfs:Class ;
rdfs:label "Health Risk Behavior" ;
rdfs:comment "Pattern of behavior which predisposes certain individuals to increased risk for contracting disease or sustaining personal injury. These behaviors may cluster into a risky lifestyle." ;
rdfs:subClassOf obo:SCDO_0000487 .
obo:SCDO_1000756 a rdfs:Class ;
rdfs:label "Tympanic Temperature" ;
rdfs:comment "The temperature of the external acoustic tube." ;
rdfs:subClassOf obo:CMO_0000015 .
obo:NCIT_C120254 a rdfs:Class ;
rdfs:label "Intelligence Scale - 16 to 90 years" ;
rdfs:comment "A standardized tool designed to assess an individual's cognitive abilities. It consists of a battery of tests that allow an investigator to conduct a comprehensive cognitive evaluation of IQ." ;
rdfs:subClassOf obo:NCIT_C122920 .
obo:CMO_0001356 a rdfs:Class ;
rdfs:label "Red Blood Cell Measurement" ;
rdfs:comment "Any measurement of a single red blood cell, one of the hemoglobin-containing blood cells that transport oxygen and carbon dioxide to and from the tissues, or of all of the red blood cells in a sample of blood." ;
rdfs:subClassOf obo:CMO_0000036 .
obo:SCDO_0006070 a rdfs:Class ;
rdfs:label "Mixed Ethnicity" ;
rdfs:comment "An ethnic group that includes persons with significant ethnic contributions from more than one group." ;
rdfs:subClassOf obo:SCDO_0003028 .
obo:HP_0011014 a rdfs:Class ;
rdfs:label "Abnormal Glucose Homeostasis" ;
rdfs:comment "Abnormality of glucose homeostasis." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_0000508 a rdfs:Class ;
rdfs:label "Hematuria" ;
rdfs:comment "Presence of blood in the urine." ;
rdfs:subClassOf obo:HP_0000077 .
obo:NCIT_C17873 a rdfs:Class ;
rdfs:label "Psychosocial Effect" ;
rdfs:comment "Having to do with the physical, psychological, cognitive, and social consequences of disease, including stigmatization of persons affected." ;
rdfs:subClassOf obo:SCDO_0000746 .
obo:SYMP_0019161 a rdfs:Class ;
rdfs:label "Muscle Pain" ;
rdfs:comment "Muscle pain is a pain characterized by pain in one or more muscles." ;
rdfs:subClassOf obo:SCDO_0000851 .
obo:SCDO_1000304 a rdfs:Class ;
rdfs:label "Hepatitis B Core IgM Antibody Test" ;
rdfs:comment "The determination of the amount of Hepatitis B virus core IgM antibody present in a sample." ;
rdfs:subClassOf obo:SCDO_1000300 .
obo:SCDO_0000753 a rdfs:Class ;
rdfs:label "Methemoglobinemia" ;
rdfs:comment "The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)" ;
rdfs:subClassOf obo:OGMS_0000047 .
obo:SCDO_1000621 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Mean Cell Volume Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's mean cell volume (MCV), as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000519 a rdfs:Class ;
rdfs:label "Hemoglobin C Disease" ;
rdfs:comment "An autosomal recessive disorder resulting from the production of hemoglobin C, secondary to an amino acid substitution of lysine for glutamic acid in the sixth position of the beta chain (E6K), and characterized by mild hemolytic anemia and occasionally jaundice, though most patients are asymptomatic." ;
rdfs:subClassOf obo:SCDO_0008262 .
obo:SCDO_0000110 a rdfs:Class ;
rdfs:label "Beta Minus Thalassemia" ;
rdfs:comment "A beta-thalassemia caused by the reduced (beta-) synthesis of the beta globin chains of the hemoglobin (Hb) tetramer." ;
rdfs:subClassOf obo:SCDO_0000111 .
obo:SCDO_1000759 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Type of Temperature Question" ;
rdfs:comment "The Sickle in Africa core data element that records the type of body temperature that was taken for the respondent." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000919 a rdfs:Class ;
rdfs:label "Prenatal Screening for Sickle Cell" ;
rdfs:comment "Prenatal detection of a fetus affected with Sickle Cell Disease using appropriate laboratory techniques. Detection of affected fetuses allows couples to make informed decisions regarding the pregnancy." ;
rdfs:subClassOf obo:SCDO_0001049 .
obo:HP_0011897 a rdfs:Class ;
rdfs:label "Neutrophilia" ;
rdfs:comment "Increased number of neutrophils circulating in blood." ;
rdfs:subClassOf obo:HP_0011991 .
obo:HP_0000821 a rdfs:Class ;
rdfs:label "Hypothyroidism" ;
rdfs:comment "Deficiency of thyroid hormone." ;
rdfs:subClassOf obo:HP_0000820 .
obo:SCDO_0000704 a rdfs:Class ;
rdfs:label "Lung Volume Measurement" ;
rdfs:comment "Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle." ;
rdfs:subClassOf obo:CMO_0000094 .
obo:NCIT_C61797 a rdfs:Class ;
rdfs:label "Ketamine" ;
rdfs:comment "A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation." ;
rdfs:subClassOf obo:CHEBI_23888 .
obo:SCDO_0001037 a rdfs:Class ;
rdfs:label "Self-Reported Weight" ;
rdfs:comment "The weight in kilograms or pounds as reported by the participant." ;
rdfs:subClassOf obo:SCDO_0000152 .
obo:HP_0100614 a rdfs:Class ;
rdfs:label "Myositis" ;
rdfs:comment "A general term for inflammation of the muscles without respect to the underlying cause." ;
rdfs:subClassOf obo:HP_0002715 , obo:SCDO_1000268 .
obo:SCDO_1000144 a rdfs:Class ;
rdfs:label "Recommendations for the Management of Sickle Cell Disease in South Africa" ;
rdfs:comment "Management protocols for the purposes of consistency and standardisation, which could also facilitate sharing of resources between centers for maximal utility. These recommendations have been developed for the South African setting, and it is intended to update them regularly to meet new demands and challenges." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_0000226 a rdfs:Class ;
rdfs:label "Chronic Kidney Disease" ;
rdfs:comment "Chronic kidney disease (CKD) is defined as either having a glomerular filtration rate (GFR) of <60 mL/min/1.73 mL for >3 months with or without kidney damage or having evidence of kidney damage for 3 months, with or without decreased GFR." ;
rdfs:subClassOf obo:HP_0000084 , obo:SCDO_0001334 .
obo:SCDO_1000206 a rdfs:Class ;
rdfs:label "Genetic Recombination" ;
rdfs:comment "Production of new arrangements of DNA by various mechanisms such as assortment and segregation, crossing over; gene conversion; genetic transformation; genetic conjugation; genetic transduction; or mixed infection of viruses." ;
rdfs:subClassOf obo:SCDO_0001369 .
obo:MP_0010066 a rdfs:Class ;
rdfs:label "Abnormal Red Blood Cell Distribution Width" ;
rdfs:comment "An anomaly in the coefficient of variance (reference range) of the red blood cell volume for an organism." ;
rdfs:subClassOf obo:HP_0001877 .
obo:SCDO_0000954 a rdfs:Class ;
rdfs:label "Quality of Life Related SCD Symptoms and Complications" ;
rdfs:comment "Sickle cell symptoms where there is evidence of some relation with quality of life." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:NCIT_C156541 a rdfs:Class ;
rdfs:label "Separated" ;
rdfs:comment "A person who is separated from their spouse, whether or not there is a legal arrangement." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_0000502 a rdfs:Class ;
rdfs:label "Heart Valve Measurement" ;
rdfs:comment "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart valves." ;
rdfs:subClassOf obo:SCDO_1000317 .
obo:OGMS_0000046 a rdfs:Class ;
rdfs:label "Epigenetic Disorder" ;
rdfs:comment "A disorder whose etiology involves (1) a modification to the patient's genomic DNA which leads to alterations in the normal expression pattern of the genome, but is (2) not a change in the nucleotide sequence." ;
rdfs:subClassOf obo:SCDO_0000444 .
obo:SCDO_0000530 a rdfs:Class ;
rdfs:label "Hemoglobin E Disease" ;
rdfs:comment """An autosomal recessive haemoglobinopathy characterized by an abnormal form of haemoglobin called haemoglobin E, which disrupts the oxygen-carrying ability of red blood cells. The condition can lead to mild or moderate hemolytic anemia; however, this condition often has no clinical manifestations.
with a generally benign, asymptomatic presentation.""" ;
rdfs:subClassOf obo:SCDO_0008262 .
obo:SCDO_0006706 a rdfs:Class ;
rdfs:label "Bioethics" ;
rdfs:comment "A branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care." ;
rdfs:subClassOf obo:NCIT_C39796 .
obo:SCDO_1000077 a rdfs:Class ;
rdfs:label "Moderate Sickle Cell Disease-S Beta Minus Thalassemia" ;
rdfs:comment "A form of sickle cell thalassemia, with a moderate clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." ;
rdfs:subClassOf obo:SCDO_0001056 .
obo:SCDO_0000073 a rdfs:Class ;
rdfs:label "Artesunate" ;
rdfs:comment "A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities." ;
rdfs:subClassOf obo:IDOMAL_0000122 , obo:SCDO_0001129 .
obo:CMO_0000123 a rdfs:Class ;
rdfs:label "Blood Bilirubin Level" ;
rdfs:comment "The amount of bilirubin found in a specific volume of blood." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_1000850 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Medical Record Number Question" ;
rdfs:comment "The Sickle in Africa core data element that records the patient's medical record number." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0012101 a rdfs:Class ;
rdfs:label "Decreased Serum Creatinine" ;
rdfs:comment "An abnormally reduced amount of creatinine in the blood." ;
rdfs:subClassOf obo:HP_0012100 .
obo:CMO_0002876 a rdfs:Class ;
rdfs:label "N-Terminal Pro-Brain Natriuretic Peptide Level" ;
rdfs:comment "The amount of N-terminal (NT)-pro hormone BNP (Nppb) in a specified volume of blood." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_1000734 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Age In Months Calculation" ;
rdfs:comment "The Sickle in Africa core data element that calculates the respondent's age in months, using the visit date and birth date collected by other core data elements." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0002939 a rdfs:Class ;
rdfs:label "Polymerised Hemoglobin" ;
rdfs:comment "Deoxygenated malfunctioning or mutated hemoglobins which clump together and form a long polymer in a process called polymerisation." ;
rdfs:subClassOf obo:SCDO_0003807 .
obo:UO_0000180 a rdfs:Class ;
rdfs:label "Mass Per Unit Volume" ;
rdfs:comment "A concentration unit which is a standard measure of the mass of a substance in a given volume (density)." ;
rdfs:subClassOf obo:UO_0000051 .
obo:SCDO_0001551 a rdfs:Class ;
rdfs:label "Ethnolinguistics" ;
rdfs:comment "A part of anthropological linguistics concerned with the interrelation between a language and the cultural behavior of those who speak it." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:DUO_0000018 a rdfs:Class ;
rdfs:label "Not for Profit Use Only" ;
rdfs:comment "This requirement indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_0000908 a rdfs:Class ;
rdfs:label "Pneumatic Retinopexy" ;
rdfs:comment "A nonincisional procedure that has become a well-accepted alternative to scleral buckling and vitrectomy for the repair of selected cases of rhegmatogenous retinal detachment." ;
rdfs:subClassOf obo:SCDO_0000833 .
obo:NCIT_C27088 a rdfs:Class ;
rdfs:label "Hyperbilirubinemia" ;
rdfs:comment "Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice." ;
rdfs:subClassOf obo:HP_0032180 .
obo:SCDO_1000890 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Systolic Blood Pressure Question" ;
rdfs:comment "The Sickle in Africa core data element that records a participant's systolic blood pressure." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001296 a rdfs:Class ;
rdfs:label "Erythrocyte Transfusion" ;
rdfs:comment "The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor." ;
rdfs:subClassOf obo:SCDO_0000138 .
obo:HP_0011007 a rdfs:Class ;
rdfs:label "Age of Onset" ;
rdfs:comment "The age group in which disease manifestations appear." ;
rdfs:subClassOf obo:NCIT_C43646 .
obo:SCDO_1000823 a rdfs:Class ;
rdfs:label "Normal White Blood Cell Count" ;
rdfs:comment "When the number of white blood cells in a specified volume of blood falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:SCDO_1000062 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S/C-Harlem" ;
rdfs:comment "A rare type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin C-Harlem. This condition is described to have a clinical course similar to sickle cell anemia." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000163 .
obo:SCDO_0000726 a rdfs:Class ;
rdfs:label "Measure of Sickle Cell Stigma (MoSCS)" ;
rdfs:comment "Measure of disease specific stigma based on patient reported outcome measurements that assesses 4 MoSCS factors: Social exclusion, Internalized Stigma, Expected Discrimination and Disclosure concerns. Measure includes stigma scores; perceived disease severity, acute care service utilization, hospital admission levels. N=262." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:SCDO_1000868 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Ethnic Group Question" ;
rdfs:comment "The Sickle in Africa core data element that records the ethnic group to which a respondent belongs." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000310 a rdfs:Class ;
rdfs:label "Cystatin C Blood Test" ;
rdfs:comment "The determination of the amount of cystatin C present in a sample." ;
rdfs:subClassOf obo:SCDO_0000133 , obo:SCDO_0000676 .
obo:SCDO_1000290 a rdfs:Class ;
rdfs:label "Hemoglobin G-Philadelphia Present" ;
rdfs:comment "When the abnormal hemoglobin, hemoglobin G-Philadelphia (Hb G-Philadelphia), has been detected in a blood sample." ;
rdfs:subClassOf obo:HP_0020061 .
obo:SCDO_1000606 a rdfs:Class ;
rdfs:label "Management Details Add Date" ;
rdfs:comment "The date on which the respondent's management details were added/recorded." ;
rdfs:subClassOf obo:SCDO_1000537 , obo:SCDO_1000590 .
obo:SCDO_0000864 a rdfs:Class ;
rdfs:label "Palpation of Liver" ;
rdfs:comment "A method of determining the shape and consistency of the liver by feeling with the fingers or hands." ;
rdfs:subClassOf obo:SCDO_0000694 .
obo:SCDO_0009635 a rdfs:Class ;
rdfs:label "deprecated Aplastic Crises" ;
rdfs:comment "'The aplastic crisis is temporary cessation of red cell production. This usually affect sickle cell patients, because of the markedly shortened red cell survival time in patients with sickle cell disease, a precipitous drop in hemoglobin occurs in the absence of adequate reticulocytosis. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0000965 a rdfs:Class ;
rdfs:label "obsolete Randomized Controlled Trial" ;
rdfs:comment "'A work that reports on a clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000283 .
obo:DOID_0050731 a rdfs:Class ;
rdfs:label "Vitamin B12 Deficiency" ;
rdfs:comment "A vitamin metabolic disorder that results from low blood levels of vitamin B12." ;
rdfs:subClassOf obo:SCDO_1000261 .
obo:HP_0001789 a rdfs:Class ;
rdfs:label "Hydrops Fetalis" ;
rdfs:comment "The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema." ;
rdfs:subClassOf obo:HP_0000969 , obo:HP_0001197 .
obo:SCDO_1000521 a rdfs:Class ;
rdfs:label "Type of Informed Consent Obtained" ;
rdfs:comment "An indication of the type of informed consent that was obtained from the respondent and/or their proxies." ;
rdfs:subClassOf obo:SCDO_1000490 .
obo:CMO_0002520 a rdfs:Class ;
rdfs:label "Serum Haptoglobin Level" ;
rdfs:comment "Measurement of the amount of haptoglobin in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Haptoglobin is a serum alpha2 globulin glycoprotein, produced by the liver, that functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_1000118 a rdfs:Class ;
rdfs:label "Dendi" ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000619 a rdfs:Class ;
rdfs:label "Immunoturbidimetry Assay" ;
rdfs:comment "An assay that employs immunoturbidimetry, a method that measures the absorbance of light from a sample which is used for quantifying an amount of analyte based on the level of turbidity produced by the formation and precipitation of an immune complex containing the analyte." ;
rdfs:subClassOf obo:NCIT_C16723 .
obo:SCDO_0000574 a rdfs:Class ;
rdfs:label "Household Roster-Relationships" ;
rdfs:comment "A record of those living in the respondent's household and about his or her relationship with them." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0001090 , obo:SCDO_1000157 .
obo:NCIT_C96239 a rdfs:Class ;
rdfs:label "Glomerular Hypertrophy" ;
rdfs:comment "A morphologic finding indicating enlargement of the glomeruli in a kidney specimen." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_0000229 a rdfs:Class ;
rdfs:label "Chronic Pain in a Specific Tissue or Organ" ;
rdfs:comment "This pain occurs in a specific tissue or organ and is usually described as constant and deep, nagging, and achy in nature." ;
rdfs:subClassOf obo:SCDO_0000233 .
obo:SCDO_0000380 a rdfs:Class ;
rdfs:label "Diclofenac" ;
rdfs:comment "A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt." ;
rdfs:subClassOf obo:CHEBI_35475 , obo:CHEBI_35493 .
obo:HP_0002181 a rdfs:Class ;
rdfs:label "Cerebral Edema" ;
rdfs:comment "Abnormal accumulation of fluid in the brain." ;
rdfs:subClassOf obo:HP_0000969 .
obo:HP_0031956 a rdfs:Class ;
rdfs:label "Elevated Serum Aspartate Aminotransferase" ;
rdfs:comment "An abnormally high concentration in the circulation of aspartate aminotransferase (AST)." ;
rdfs:subClassOf obo:HP_0012379 .
obo:SCDO_0001249 a rdfs:Class ;
rdfs:label "X-Ray Image" ;
rdfs:comment "The visual output that an X-ray machine produces." ;
rdfs:subClassOf obo:SCDO_1000313 .
obo:NCIT_C78393 a rdfs:Class ;
rdfs:label "Iron Overload" ;
rdfs:comment "Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_1000546 a rdfs:Class ;
rdfs:label "Self-Reported Current Age (Years)" ;
rdfs:comment "The length of time that a person has lived since their birth up until the current day, as reported in years by the respondent." ;
rdfs:subClassOf obo:SCDO_0000304 .
obo:SCDO_1000863 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Height Question" ;
rdfs:comment "The Sickle in Africa core data element that records a respondent's height." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001048 a rdfs:Class ;
rdfs:label "Sickle Cell Disease Pain Burden Interview - Youth" ;
rdfs:comment "The SCPBI-Y is a brief clinical interview designed to assess pain burden for children and adolescents with SCD." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:SCDO_0000277 a rdfs:Class ;
rdfs:label "obsolete Consensus Development Conference" ;
rdfs:comment "'A work that consists of summary statements representing the majority and current agreement of physicians, scientists, and other professionals meeting to reach a consensus on a selected subject. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000941 .
obo:SCDO_1000509 a rdfs:Class ;
rdfs:label "SickleInAfrica Core Data Element" ;
rdfs:comment "A data element in the SickleInAfrica core data capture instrument." ;
rdfs:subClassOf obo:SCDO_1000508 .
obo:NCIT_C81262 a rdfs:Class ;
rdfs:label "Medical Record Number" ;
rdfs:comment "An identifying number within an institution that is used to reference a subject's medical information." ;
rdfs:subClassOf obo:NCIT_C69256 .
obo:SCDO_1000482 a rdfs:Class ;
rdfs:label "deprecated Dropdown Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:NCIT_C95504 a rdfs:Class ;
rdfs:label "Hemoglobin H Disease" ;
rdfs:comment "A form of alpha thalassemia that results from reduced protein production from three of the four alpha-globin genes. Clinically it is characterized by chronic hemolytic anemia." ;
rdfs:subClassOf obo:SCDO_0000042 .
obo:SCDO_1000117 a rdfs:Class ;
rdfs:label "Bariba" ;
rdfs:comment "Bariba is the ethnic group dominating the northern side of Benin, who constitute 9% of the population. They are the first inhabitants of Benin and are concentrated in the capital city, Nikki. One of their leading practices is horse riding, which is a practice that has been enjoyed from generation to generation. With agriculture being their dominant occupation, Bariba people have a diverse range of produce such as corn, rice and palm oil." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:HP_0000980 a rdfs:Class ;
rdfs:label "Pallor" ;
rdfs:comment "Abnormally pale skin." ;
rdfs:subClassOf obo:HP_0011121 .
obo:SCDO_1000178 a rdfs:Class ;
rdfs:label "SickleInAfrica Extended Demographics Data Element" ;
rdfs:comment "A data element in the SickleInAfrica Extended Demographics data capture instrument." ;
rdfs:subClassOf obo:SCDO_1000508 .
obo:SCDO_0001069 a rdfs:Class ;
rdfs:label "Sickness Impact Profile (SIP)" ;
rdfs:comment "A generic measure used to evaluate the impact of SCD on both physical and emotional functioning of an affected person. SIP is designed to measure perceived health status and to be used as an outcome measure for evaluation, program planning, and policy formation related to health care. It is designed in such a way as to reflect sensitivity to changes and/or differences in health status and to be applicable across a broad range of types and severities of the SCD illness, as well as different demographic and cultural groups." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:HP_0001744 a rdfs:Class ;
rdfs:label "Splenomegaly" ;
rdfs:comment "Abnormal increased size of the spleen." ;
rdfs:subClassOf obo:HP_0001743 .
obo:NCIT_C40438 a rdfs:Class ;
rdfs:label "Beck Depression Inventory-II (BDI-II)" ;
rdfs:comment "The BDI-II is the most widely used instrument for measuring depression. It consists of 21 items to assess the intensity of depression in clinical and normal patients. Each item is a list of four statements arranged in increasing severity about a particular symptom of depression, and rated on a scale of 0 to 3." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_1000682 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Lactate Dehydrogenase Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the level of lactate dehydrogenase in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000653 a rdfs:Class ;
rdfs:label "deprecated-Intracerebral Haemorrhage" ;
rdfs:comment "Intracerebral hemorrhage (ICH) is when blood suddenly bursts into brain tissue, causing damage to the brain." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0000330 a rdfs:Class ;
rdfs:label "D57.80 Other sickle-cell disorders without crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000329 .
obo:SCDO_1000401 a rdfs:Class ;
rdfs:label "Data Descriptor" ;
rdfs:comment "A characteristic that further describes the nature of data." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:HP_0004825 a rdfs:Class ;
rdfs:label "Increased Hemoglobin Oxygen Affinity" ;
rdfs:comment "An abnormal increase in the binding affinity of hemoglobin for oxygen." ;
rdfs:subClassOf obo:HP_0020054 .
obo:SCDO_0000568 a rdfs:Class ;
rdfs:label "History of Stroke - Ischemic Infarction and Hemorrhage - Diagnostic Instrument" ;
rdfs:comment "A questionnaire to determine if the respondent has had an ischemic infarction (i.e. stroke) and/or any symptoms related to this event." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:HP_0012418 a rdfs:Class ;
rdfs:label "Hypoxemia" ;
rdfs:comment "An abnormally low level of blood oxygen." ;
rdfs:subClassOf obo:MP_0002329 .
obo:MP_0011468 a rdfs:Class ;
rdfs:label "Abnormal Urine Amino Acid Level" ;
rdfs:comment "Any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group." ;
rdfs:subClassOf obo:HP_0003110 .
obo:SCDO_0004716 a rdfs:Class ;
rdfs:label "Initiator Codon" ;
rdfs:comment "A codon that directs initiation of protein translation (Translation, Genetic) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon." ;
rdfs:subClassOf obo:SCDO_0004623 .
obo:HP_0011893 a rdfs:Class ;
rdfs:label "Abnormal Leukocyte Count" ;
rdfs:comment "Number of leukocytes per volume of blood beyond normal limits." ;
rdfs:subClassOf obo:SCDO_1000612 .
obo:HP_0011122 a rdfs:Class ;
rdfs:label "Abnormality of Skin Physiology" ;
rdfs:comment "Any abnormality of the physiological function of the skin." ;
rdfs:subClassOf obo:HP_0000951 .
obo:HP_0001871 a rdfs:Class ;
rdfs:label "Abnormality of Blood and Blood-Forming Tissues" ;
rdfs:comment "An abnormality of the hematopoietic system." ;
rdfs:subClassOf obo:HP_0000118 , obo:SCDO_1000820 .
obo:SCDO_0000259 a rdfs:Class ;
rdfs:label "Clinical Trials as Topic" ;
rdfs:comment "Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries." ;
rdfs:subClassOf obo:SCDO_0000253 .
obo:SCDO_0000323 a rdfs:Class ;
rdfs:label "D57.4 Sickle-cell thalassemia" ;
rdfs:comment "Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene." ;
rdfs:subClassOf obo:SCDO_0000311 .
obo:SCDO_0000219 a rdfs:Class ;
rdfs:label "Child-Reported Parental Education Attainment" ;
rdfs:comment "A parent's highest level of education obtained, as reported by the child." ;
rdfs:subClassOf obo:SCDO_0000305 .
obo:CHEBI_5790 a rdfs:Class ;
rdfs:label "Hydromorphone" ;
rdfs:comment "An opioid analgesic derived from morphine and used mainly as an analgesic. It has a shorter duration of action and is more potent than morphine." ;
rdfs:subClassOf obo:CHEBI_35482 .
obo:SCDO_0000190 a rdfs:Class ;
rdfs:label "Catheter" ;
rdfs:comment "A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity." ;
rdfs:subClassOf obo:SCDO_0000376 , obo:SCDO_0001150 .
obo:SCDO_0005464 a rdfs:Class ;
rdfs:label "Myocardial Ischemia" ;
rdfs:comment "A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction)." ;
rdfs:subClassOf obo:SCDO_0000665 .
obo:SCDO_0000976 a rdfs:Class ;
rdfs:label "Reduced Hemoglobin A" ;
rdfs:comment "Hemoglobin A (HbA) contains two alpha-globin chains and two beta-globin chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decrease in the proportion of HbA below this limit, and can be seen in various forms of thalassemia." ;
rdfs:subClassOf obo:HP_0020062 , obo:SCDO_1000061 .
obo:SCDO_0001321 a rdfs:Class ;
rdfs:label "Fentanyl" ;
rdfs:comment "A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance." ;
rdfs:subClassOf obo:CHEBI_35482 .
obo:SCDO_0000950 a rdfs:Class ;
rdfs:label "Quality of Life and Care" ;
rdfs:comment "The subjective measurement of an individual's sense of well-being and ability to enjoy life, and the levels of excellence which characterize the health service or health care provided to individuals based on accepted standards of quality." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:HP_0001935 a rdfs:Class ;
rdfs:label "Microcytic Anemia" ;
rdfs:comment "A kind of anemia in which the volume of the red blood cells is reduced." ;
rdfs:subClassOf obo:HP_0001903 .
obo:SCDO_0000557 a rdfs:Class ;
rdfs:label "obsolete Hepatitis B Test" ;
rdfs:comment "A test for Hepatitis B Virus." ;
rdfs:subClassOf obo:SCDO_1000034 .
obo:SCDO_1000107 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/Beta Thalassemia" ;
rdfs:comment "The combination of the hemoglobin S mutation (beta6Glu>Val) and a beta-thalassemia mutation." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:SCDO_0000676 a rdfs:Class ;
rdfs:label "Kidney Function Test" ;
rdfs:comment "Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_1000487 a rdfs:Class ;
rdfs:label "deprecated Text Box Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:MP_0001212 a rdfs:Class ;
rdfs:label "Skin Lesions" ;
rdfs:comment "Focal pathological and/or inflammatory changes characterized by alteration in the size, shape and organization of the cellular components of the skin." ;
rdfs:subClassOf obo:HP_0011123 .
obo:SCDO_0000299 a rdfs:Class ;
rdfs:label "Culture" ;
rdfs:comment "A collective expression for all behaviour patterns acquired and socially transmitted through symbols. Culture includes customs, traditions, and language." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:SCDO_0001004 a rdfs:Class ;
rdfs:label "Reticulocyte Count" ;
rdfs:comment "The number of reticulocytes per unit volume of blood. The values are expressed as a percentage of the erythrocyte count or in the form of an index (\"corrected reticulocyte index\"), which attempts to account for the number of circulating erythrocytes." ;
rdfs:subClassOf obo:CMO_0000025 .
obo:SCDO_0000084 a rdfs:Class ;
rdfs:label "Assessment of Short-Axis Cardiac Function by MRI" ;
rdfs:comment "This measure is a magnetic resonance imaging (MRI) method of capturing an individual's heart performance, and is considered the gold standard for capturing ventricular volumes and mass. It is used to detect cardiac abnormalities, such as cardiomyopathies, myocardial fibrosis, and infarction." ;
rdfs:subClassOf obo:NCIT_C16809 , obo:SCDO_0000500 .
obo:SCDO_1000552 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Date of Diagnosis Known Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether the respondent knows the date of their SCD diagnosis." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000842 a rdfs:Class ;
rdfs:label "Hypocapnia" ;
rdfs:comment "Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood." ;
rdfs:subClassOf obo:MP_0002329 .
obo:NCIT_C70731 a rdfs:Class ;
rdfs:label "Clinical Trial Subject Unique Identifier" ;
rdfs:comment "A unique identifier assigned to each clinical trial subject to protect the subject's identity and used in lieu of the subject's name when the investigator reports adverse events and/or other trial-related data." ;
rdfs:subClassOf obo:NCIT_C69256 .
obo:SCDO_1000231 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype O-Arab" ;
rdfs:comment "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 121 of beta-globin chains (hemoglobin O-Arab mutation) produced by both beta-globin gene (HBB) alleles." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:HP_0002913 a rdfs:Class ;
rdfs:label "Myoglobinuria" ;
rdfs:comment "Presence of myoglobin in the urine." ;
rdfs:subClassOf obo:HP_0000079 .
obo:SCDO_1000126 a rdfs:Class ;
rdfs:label "Kisii" ;
rdfs:comment "The Kisii tribe (also known as the Gusii tribe) is a Bantu ethnic group who occupy the Kisii highlands in Nyanza, Western Kenya. The Kisiis constitute the sixth largest ethnic group, comprising about seven percent of the national population. Kisii, which is their ethnic language, is also traditionally known as Ekegusii." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000879 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Next of Kin Number Question" ;
rdfs:comment "The Sickle in Africa core data element that records the telephone number of the participant's next of kin." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:NCIT_C129072 a rdfs:Class ;
rdfs:label "Hereditary Persistence of Fetal Hemoglobin" ;
rdfs:comment "The persistence of substantial fetal hemoglobin production into adulthood, usually associated with hemoglobinopathies due to mutations in the alpha and/or beta chain of hemoglobin." ;
rdfs:subClassOf obo:SCDO_0007192 .
obo:SCDO_1000155 a rdfs:Class ;
rdfs:label "Family Study" ;
rdfs:comment "Research conducted on members of families, examining the affects of genetics, the environment, or twin offspring." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_0000711 a rdfs:Class ;
rdfs:label "Marital Status of Primary Caregiver" ;
rdfs:comment "The current marital status of the respondent's caregiver (i.e. family member or another individual who takes primary responsibility for the respondent)." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_0001090 , obo:SCDO_1000157 .
obo:NCIT_C114300 a rdfs:Class ;
rdfs:label "Carboxyhemoglobin" ;
rdfs:comment "Hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO). This complex is produced after CO has been inhaled or as a byproduct of hemoglobin, protoporphyrin or dichloromethane catabolism. The heme-CO complex is approximately 200 times more stable than heme-oxygen complexes. Thus, high levels of carboxyhemoglobin in the circulation can lead to tissue hypoxia and death." ;
rdfs:subClassOf obo:NCIT_C16676 .
obo:SCDO_1000788 a rdfs:Class ;
rdfs:label "D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000325 .
obo:SCDO_1000166 a rdfs:Class ;
rdfs:label "Sickle Cell Disease C/S Antilles" ;
rdfs:comment "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta 23 Val>Ile mutation. The other beta globin allele produces normal beta globin chains." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000211 .
obo:HP_0000876 a rdfs:Class ;
rdfs:label "Oligomenorrhea" ;
rdfs:comment "Infrequent menses (less than 6 per year or more than 35 days between cycles)." ;
rdfs:subClassOf obo:HP_0012243 .
obo:SCDO_1000336 a rdfs:Class ;
rdfs:label "Frequency of Sickle Cell Pain Episodes" ;
rdfs:comment "The frequency of acute pain episodes due to sickle cell disease (SCD)." ;
rdfs:subClassOf obo:SCDO_1000318 .
obo:SCDO_0300002 a rdfs:Class ;
rdfs:label "Research Ethics" ;
rdfs:comment "The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic." ;
rdfs:subClassOf obo:NCIT_C39796 , obo:SCDO_0300005 .
obo:SCDO_0000682 a rdfs:Class ;
rdfs:label "Lactate Dehydrogenase Level" ;
rdfs:comment "The level of lactate dehydrogenase, an enzyme released during tissue damage and injury, found in a specified biological specimen." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_0008037 a rdfs:Class ;
rdfs:label "Acute Symptomatic Seizure" ;
rdfs:comment "A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed. It is often associated with infections, infarctions, and severe metabolic or sickle cell complications." ;
rdfs:subClassOf obo:SCDO_1000000 .
obo:SCDO_1000094 a rdfs:Class ;
rdfs:label "Research Benefit" ;
rdfs:comment "A desirable research outcome or state of affairs, such as medical treatment, clinically useful information, or self-esteem. In the oversight of human subjects research, money is usually not treated as a benefit." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0009613 a rdfs:Class ;
rdfs:label "Protein Phenotype" ;
rdfs:comment "The physical characteristics and levels of proteins that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." ;
rdfs:subClassOf obo:SCDO_0009884 .
obo:SCDO_1000051 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/O-Arab" ;
rdfs:comment "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin O-Arab (HBB GluU121Lys) variants." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:HP_0010876 a rdfs:Class ;
rdfs:label "Abnormal Circulating Protein Level" ;
rdfs:comment "An abnormal level of a circulating protein in the blood." ;
rdfs:subClassOf obo:HP_0032180 .
obo:SCDO_1000224 a rdfs:Class ;
rdfs:label "Easy Bruisability" ;
rdfs:comment "Increased susceptibility to bruising." ;
rdfs:subClassOf obo:HP_0002597 .
obo:GSSO_000109 a rdfs:Class ;
rdfs:label "Intersex" ;
rdfs:comment "Intersex is an umbrella term with a complex history. It is usually used to refer to persons with congenital conditions which involve differences in the many intertwined processes of sexual development." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_1000315 a rdfs:Class ;
rdfs:label "Serum HDL Cholesterol Test" ;
rdfs:comment "A quantitative measurement of the amount of HDL cholesterol present in a sample of serum." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_1000834 a rdfs:Class ;
rdfs:label "Normal Reticulocyte Count" ;
rdfs:comment "When the number of reticulocytes in a specified volume of blood falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:SCDO_0000748 a rdfs:Class ;
rdfs:label "Metabolic State" ;
rdfs:comment "The state of the chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (anabolism) and the breakdown (catabolism) of organic materials utilized by the living organism." ;
rdfs:subClassOf obo:SCDO_0000122 .
obo:SCDO_1000260 a rdfs:Class ;
rdfs:label "Symptom Induced by Strenuous Exercise" ;
rdfs:comment "Any feeling of illness or physical or mental change that results from strenuous exercise." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0001080 a rdfs:Class ;
rdfs:label "Smoking Cessation" ;
rdfs:comment "Discontinuing the habit of smoking." ;
rdfs:subClassOf obo:SCDO_0001159 .
obo:HP_0007340 a rdfs:Class ;
rdfs:label "Leg Weakness" ;
rdfs:comment "Weakness of the muscles of the legs." ;
rdfs:subClassOf obo:HP_0025142 , obo:SCDO_1000268 .
obo:SCDO_1000009 a rdfs:Class ;
rdfs:label "Hemoglobin E" ;
rdfs:comment "An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_0003807 .
obo:HP_0002516 a rdfs:Class ;
rdfs:label "Intracranial Hypertension" ;
rdfs:comment "An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid." ;
rdfs:subClassOf obo:HP_0000822 , obo:HP_0012638 .
obo:SCDO_1000707 a rdfs:Class ;
rdfs:label "Hemoglobin F Level" ;
rdfs:comment "The amount of hemoglobin F present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:SCDO_0000208 a rdfs:Class ;
rdfs:label "Cerebral Function Assay" ;
rdfs:comment "A test of how well the cerebrum is functioning." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_1000687 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hb Assay Results Recorded Question" ;
rdfs:comment "The Sickle in Africa core data element that records the hemoglobins for which assay results were recorded." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000400 a rdfs:Class ;
rdfs:label "Drug Intolerance AE" ;
rdfs:comment "A drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:SCDO_0001166 a rdfs:Class ;
rdfs:label "Transcranial Doppler Ultrasonography" ;
rdfs:comment "A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum." ;
rdfs:subClassOf obo:NCIT_C154865 , obo:NCIT_C17230 , obo:SCDO_0001129 .
obo:HP_0001513 a rdfs:Class ;
rdfs:label "Obesity" ;
rdfs:comment "Body weight that is grossly above the acceptable or desirable weight, usually due to accumulation of excess fats in the body. The standards may vary with age, sex, genetic or cultural background. In the body mass index (BMI), a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese." ;
rdfs:subClassOf obo:HP_0001507 .
obo:HP_0003457 a rdfs:Class ;
rdfs:label "EMG Abnormality" ;
rdfs:comment "Abnormal results of investigations using electromyography (EMG)." ;
rdfs:subClassOf obo:SCDO_1000268 .
obo:SCDO_0000006 a rdfs:Class ;
rdfs:label "Ability to Carry Out Activities of Daily Living" ;
rdfs:comment "The performance of the basic activities of self care, such as dressing, ambulation, or eating." ;
rdfs:subClassOf obo:SCDO_0000900 .
obo:SCDO_0000665 a rdfs:Class ;
rdfs:label "Ischemia" ;
rdfs:comment "A hypoperfusion of the blood through an organ or tissue caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation." ;
rdfs:subClassOf obo:HP_0001626 .
obo:SCDO_1000726 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Methemoglobin Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's methemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000874 a rdfs:Class ;
rdfs:label "Nearest Geographical Landmark" ;
rdfs:comment "A recognizable natural or artificial geographic feature, used for navigation (often visible from long distances), that is nearest to where the participant lives." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_0000546 a rdfs:Class ;
rdfs:label "Hemoglobin Profile" ;
rdfs:comment "The type and relative amounts of various normal and abnormal hemoglobin types." ;
rdfs:subClassOf obo:CMO_0000508 .
obo:NCIT_65495 a rdfs:Class ;
rdfs:label "Duloxetine" ;
rdfs:comment "A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001133 .
obo:SCDO_0001267 a rdfs:Class ;
rdfs:label "EuroQol Five Dimensions Questionnaire (EQ-5D)" ;
rdfs:comment "The EQ-5D is a widely-used generic instrument for describing health-related quality of life states in five dimensions scored from 1 to 3 or 1 to 5, and a visual analogue scale to record self-rated health state from 0 to100. These provide a simple descriptive profile and a single index value for health status. The EQ-5D can also be used to calculate health utilities and determine the quality-adjusted life years associated with a health state. There is also a youth version (EQ-5D-Y)." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:SCDO_1000054 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype SD" ;
rdfs:comment "Compound heterozygous inheritance of Hb S and Hb D mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb D generally results from substitution of glutamic acid for glutamine at beta-121 (beta121Glu>Gln); such as the Hb D-Punjab/Hb D-Los Angeles variants. There are several other Hb D variants, including Hb D-Iband where threonine is substituted by lysine at beta-87 (beta87Thr>Lys) and Hb D-Iran where glutamic acid is substituted by glutamine at beta-22 (beta22Glu>Gln)." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:SCDO_1000585 a rdfs:Class ;
rdfs:label "Blood Type B Negative" ;
rdfs:comment "A blood type containing type B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor." ;
rdfs:subClassOf obo:HP_0032224 .
obo:SCDO_1000857 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Middle Name Question" ;
rdfs:comment "The Sickle in Africa core data element that records a respondent's middle name." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000213 a rdfs:Class ;
rdfs:label "deprecated Disease Caused by A/S-Oman Genotype" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000297 a rdfs:Class ;
rdfs:label "Quality of Life and Care Diagnostic Instrument" ;
rdfs:comment "A diagnostic instrument that involves an assessment of quality of life- and/or quality of care-related elements." ;
rdfs:subClassOf obo:SCDO_1000033 .
obo:SCDO_1000014 a rdfs:Class ;
rdfs:label "HBD" ;
rdfs:comment "This gene encodes the hemoglobin subunit delta, which is a component of hemoglobin A2, which plays a role in the transport of oxygen to tissues of the adult body, but exists only in small amounts in all adult humans (1.5-3.1% of all hemoglobin molecules)." ;
rdfs:subClassOf obo:SCDO_1000362 .
obo:SCDO_1000326 a rdfs:Class ;
rdfs:label "Ever-Smoker" ;
rdfs:comment "A person who has smoked a cigarette in the past, even if just one or two puffs, but was unable to or refused to answer when asked when the last time was that they smoked a cigarette, even one or two puffs." ;
rdfs:subClassOf obo:SCDO_0000235 .
obo:SCDO_0000972 a rdfs:Class ;
rdfs:label "Recurrent Wheeze in Sickle Cell Disease" ;
rdfs:comment "Recurrent episodes of wheezing in persons with SCD who have no co-morbid asthma." ;
rdfs:subClassOf obo:SCDO_0000895 .
obo:SCDO_0000737 a rdfs:Class ;
rdfs:label "Medical Outcomes Study (MOS) Social Support Survey" ;
rdfs:comment "The MOS Social Support Survey is a self-administered questionnaire that includes 19 items across four functional support subscales: emotional/informational support (8 items), tangible/instrumental support (4 items), affectionate support (3 items), and positive social interaction (3 items). Each item is scored on a 5-point Likert style scale (1 = None of the Time; 5 = All of the Time) to indicate how often that type of support is available to them. A score for each social support subscale can be computed by averaging across the individual items or by adding scores individual items together. Higher scores indicate more support." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:SCDO_0000132 a rdfs:Class ;
rdfs:label "Black Sunburst Lesion" ;
rdfs:comment "Black lesions in the retina that form at the border of perfused and nonperfused retina that are caused by the migration of hyperplastic retinal pigment epithelial cells into sensory retina. The sensory retina surrounding the lesion is atrophic." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:SCDO_1000133 a rdfs:Class ;
rdfs:label "Mijikenda/Swahili" ;
rdfs:comment "The Mijikenda tribe is a Kenyan coastal Bantu tribe that consists of nine closely related sub-tribes. \"Mijikenda\" literally means nine homes or nine homesteads (in Swahili), referring to the common ancestry of the Mijikenda people. The nine Mijikenda sub-tribes are believed to be nine different homes of the same tribe. Each sub-tribe speaks its own dialect of the Mijikenda language." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000394 a rdfs:Class ;
rdfs:label "Gene Component" ;
rdfs:comment "A gene component is a component of a gene." ;
rdfs:subClassOf obo:SCDO_0005722 .
obo:SCDO_0007519 a rdfs:Class ;
rdfs:label "Community Engagement" ;
rdfs:comment "A process of inclusive participation that supports mutual respect of values, strategies, and actions for authentic partnership of people affiliated by geographic location, shared interest, or similar circumstances to address issues affecting community wellbeing." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_1000160 a rdfs:Class ;
rdfs:label "Guideline" ;
rdfs:comment "Work consisting of a set of statements, directions, or principles presenting current or future rules or policy. Guidelines may be developed by government agencies at any level, institutions, organizations such as professional societies or governing boards, or by the convening of expert panels. The text may be cursive or in outline form, but it is generally a comprehensive guide to problems and approaches in any discipline or activity. This concept relates to the general conduct and administration of health care activities rather than to specific decisions for a particular clinical condition." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_1000794 a rdfs:Class ;
rdfs:label "D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000791 .
obo:SCDO_1000364 a rdfs:Class ;
rdfs:label "Hemoglobin A2" ;
rdfs:comment "An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia." ;
rdfs:subClassOf obo:SCDO_0006835 .
obo:NCIT_C103526 a rdfs:Class ;
rdfs:label "Patient Health Questionnaire-9 (PHQ-9)" ;
rdfs:comment "A 9-item scale using each of the 9 DSM-IV criteria with self-reported frequency of \"0\" (not at all) to \"3\" (nearly every day). One of the most widely used instruments to assess depression, PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression, respectively." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_0000491 a rdfs:Class ;
rdfs:label "Health Literacy" ;
rdfs:comment "Degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions." ;
rdfs:subClassOf obo:SCDO_0000286 .
obo:SCDO_0000581 a rdfs:Class ;
rdfs:label "Hydroxyurea-Induced Adverse Event" ;
rdfs:comment "A causal adverse drug event that is induced by hydroxyurea." ;
rdfs:subClassOf obo:SCDO_0000191 .
obo:SCDO_1000073 a rdfs:Class ;
rdfs:label "Hemoglobin S-Antilles" ;
rdfs:comment "A form of hemoglobin caused by two mutations in its beta-chains, the classic beta S mutation (beta 6 Glu>Val) and beta 23 Val>Ile. Hemoglobin S-Antilles has the same electrophoretic mobility as Hemoglobin S but a distinct isoelectric focus and produces sickling in the carriers of the Hb A/S Antilles trait." ;
rdfs:subClassOf obo:SCDO_1000082 .
obo:SCDO_1000148 a rdfs:Class ;
rdfs:label "Standards for Clinical Care of Adults with Sickle Cell Disease in the UK" ;
rdfs:comment "A document that includes standards and guidelines for clinical care and recommendations for how care for adults with sickle cell disease should be delivered." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_0001339 a rdfs:Class ;
rdfs:label "Functionality After Stroke Measure" ;
rdfs:comment "A questionnaire to measure the health status of individuals who had a stroke." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:HP_0000843 a rdfs:Class ;
rdfs:label "Hyperparathyroidism" ;
rdfs:comment "Excessive production of parathyroid hormone (PTH) by the parathyroid glands." ;
rdfs:subClassOf obo:HP_0000828 .
obo:SCDO_1000212 a rdfs:Class ;
rdfs:label "deprecated Disease Caused by A/Jamaica Plain Genotype" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000280 a rdfs:Class ;
rdfs:label "Consumer Assessment of Healthcare Providers and Systems (CAHPS) Health Plan Survey 4.0 Child Medicaid Questionnaire" ;
rdfs:comment "A tool for collecting standardized information on enrollees' experiences with health plans and their services." ;
rdfs:subClassOf obo:SCDO_0000947 .
obo:SCDO_0000570 a rdfs:Class ;
rdfs:label "History of Type I and Type 2 Diabetes Diagnostic Instrument" ;
rdfs:comment "A questionnaire to determine a respondent's history of type 1 or type 2 diabetes." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_1000296 a rdfs:Class ;
rdfs:label "ASCQ-Me Score" ;
rdfs:comment "The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me) diagnostic instrument." ;
rdfs:subClassOf obo:SCDO_1000295 .
obo:SCDO_0000878 a rdfs:Class ;
rdfs:label "PedsQL Sickle Cell Disease Module" ;
rdfs:comment "The PedsQL Sickle Cell Disease Module includes 43 items from 9 subscales: Pain and Hurt (9 items); Pain Impact (10 items); Pain Management and Control (2 items); Worry (5 items); Worry II (2 items); Emotions (2 items); Treatment (7 items); Communication I (3 items); and Communication II (3 items). For all ages, each item asks how much of a problem there has been in the past month. There are self- or parent-reported forms for ages 8 to 18, and responses are scored on a 5-point Likert-style scale (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). Forms for children ages 5 to 7 are interviewer-administered, and responses include a 3-point Likert-style scale (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reversed-scored and converted to a 100-point scale (0 = 100, 1 = 75, 2 = 50, 3 = 25, 4 = 0) with higher scores indicating better quality of life. Scores for individual subscales are the sum of items divided by the total number or items answered. The total score for the PedsQL Sickle Cell Disease Module is the sum of the items divided by the number of items answered." ;
rdfs:subClassOf obo:NCIT_C78652 .
obo:HP_0003077 a rdfs:Class ;
rdfs:label "Hyperlipidemia" ;
rdfs:comment "An elevated lipid concentration in the blood." ;
rdfs:subClassOf obo:HP_0003611 .
obo:SCDO_1000448 a rdfs:Class ;
rdfs:label "Adjunct Analgesic Agent" ;
rdfs:comment "A medication that is typically used for indications other than pain control but provides control of pain in some painful diseases." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:SCDO_1000066 a rdfs:Class ;
rdfs:label "Hemoglobin F Test" ;
rdfs:comment "The determination of the amount of hemoglobin F present in a sample." ;
rdfs:subClassOf obo:SCDO_0000522 .
obo:NCIT_C50767 a rdfs:Class ;
rdfs:label "Tachypnea" ;
rdfs:comment "Abnormal increase of rate of breathing." ;
rdfs:subClassOf obo:HP_0002086 .
obo:SCDO_0007161 a rdfs:Class ;
rdfs:label "Acute Splenic Sequestration Crisis" ;
rdfs:comment "Significant change in blood picture characterised by a precipitous fall in the haemoglobin level of at least 20 g/l and accompanied by a rapidly enlarging spleen or liver (greater than 2 cm from the steady state level) and reticulocytosis above the steady state level for each individual patient. Signs of acute circulatory insufficiency such tachypnoea, tachycardia, and hypotension may or may not be present. It is the earliest life-threatening complication seen in patients with SCD besides pneumococcal infections." ;
rdfs:subClassOf obo:SCDO_0000895 , obo:SCDO_1000000 .
obo:SCDO_1000321 a rdfs:Class ;
rdfs:label "Cigarette Smoking Status Diagnostic Instrument - Adolescent" ;
rdfs:comment "Questions asking an adolescentt respondent about smoking status in his or her entire life." ;
rdfs:subClassOf obo:SCDO_1000319 .
obo:SBO_0000316 a rdfs:Class ;
rdfs:label "MicroRNA" ;
rdfs:comment "Single-stranded RNA molecules thought to regulate the expression of other genes. miRNAs are encoded by genes that are transcribed from DNA but not translated into protein (non-coding RNA)." ;
rdfs:subClassOf obo:NCIT_C26548 .
obo:CMO_0000665 a rdfs:Class ;
rdfs:label "Heart Contraction Pressure" ;
rdfs:comment "Pressure exerted by the heart muscle in its maximally contracted state." ;
rdfs:subClassOf obo:SCDO_1000317 .
obo:SCDO_0000288 a rdfs:Class ;
rdfs:label "Coping Strategies Questionnaire revised for Sickle Cell Disease Children (CSQ-SCD Children)" ;
rdfs:comment "The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:SCDO_0000932 a rdfs:Class ;
rdfs:label "Proteinuria" ;
rdfs:comment "Increased amounts of any protein (including albumin) in the urine - typically more than 300mg in a 24hr period." ;
rdfs:subClassOf obo:HP_0003110 .
obo:SCDO_0000489 a rdfs:Class ;
rdfs:label "Health Financing" ;
rdfs:comment "Health financing is concerned with how financial resources are generated, allocated and used in health systems. Health financing policy focuses on how to move closer to universal coverage with issues related to: (i) how and from where to raise sufficient funds for health; (ii) how to overcome financial barriers that exclude many poor from accessing health services; or (iii) how to provide an equitable and efficient mix of health services." ;
rdfs:subClassOf obo:SCDO_0000494 .
obo:HP_0003302 a rdfs:Class ;
rdfs:label "Spondylolisthesis" ;
rdfs:comment "Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_0003736 a rdfs:Class ;
rdfs:label "Dynamic Consent" ;
rdfs:comment "Dynamic consent is a personalised, communication interface to enable greater participant engagement in clinical and research activities.The interface facilitates two-way communication to stimulate a more engaged, informed and scientifically literate participant population where individuals can tailor and manage their own consent preferences. It has the potential to be applied more broadly to situations where there are multiple and varied uses of data requiring different kinds of consent over a period of time." ;
rdfs:subClassOf obo:SCDO_0007087 .
obo:DUO_0000022 a rdfs:Class ;
rdfs:label "Geographical Restriction" ;
rdfs:comment "This should be coupled with an ontology term describing the geographical location the restriction applies to." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_1000462 a rdfs:Class ;
rdfs:label "Research Ethics Committee Decision" ;
rdfs:comment "A decision made by a research ethics committee." ;
rdfs:subClassOf obo:SCDO_1000430 .
obo:SCDO_1000207 a rdfs:Class ;
rdfs:label "Homologous Recombination" ;
rdfs:comment "An exchange of DNA between matching or similar sequences." ;
rdfs:subClassOf obo:SCDO_1000206 .
obo:HP_0000951 a rdfs:Class ;
rdfs:label "Abnormality of the Skin" ;
rdfs:comment "An abnormality of the skin." ;
rdfs:subClassOf obo:HP_0001574 .
obo:SCDO_0001025 a rdfs:Class ;
rdfs:label "Scleral Buckling" ;
rdfs:comment "An operation for retinal detachment which reduces the size of the globe by indenting the sclera so that it approximates the retina." ;
rdfs:subClassOf obo:SCDO_0000833 .
obo:SCDO_1000803 a rdfs:Class ;
rdfs:label "D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000798 .
obo:NCIT_C69256 a rdfs:Class ;
rdfs:label "Subject Unique Identifier" ;
rdfs:comment "A unique identifier for a subject in a study." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_0300004 , obo:SCDO_0300005 .
obo:SCDO_1000174 a rdfs:Class ;
rdfs:label "Non-Billable ICD-10-CM Code" ;
rdfs:comment "An ICD-10-CM diagnosis code that is not billable as there are more specific codes below it that contain a greater level of detail." ;
rdfs:subClassOf obo:SCDO_1000100 .
obo:SCDO_1000105 a rdfs:Class ;
rdfs:label "Alpha-Globin Family Members" ;
rdfs:comment "Members of the alpha-globin family. In humans, they are encoded in a gene cluster on chromosome 16. They include hemoglobin subunit zeta and hemoglobin subunit alpha. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult hemoglobin is comprised of 2 alpha-globin chains and 2 beta-globin chains." ;
rdfs:subClassOf obo:SCDO_0005339 , obo:SCDO_1000104 .
obo:SCDO_0008990 a rdfs:Class ;
rdfs:label "Vertebral Collapse" ;
rdfs:comment "Occurs where there is infarction of vertebral bone marrow, leading to collapse of the vertebrae with a typical 'fish mouth' appearance. It is often asymptomatic, but may cause acute and/or long term pain requiring analgesia and mechanical support such as a brace. Can be an acute or chronic bone problem in SCD." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_1000122 a rdfs:Class ;
rdfs:label "Embu" ;
rdfs:comment "The Embu are a Bantu-speaking people who are closely related to the Gikuyu of Ndia and Gicugu to the west, the Mbeere and the Kamba to the southeast, and the Chuka and the Meru to the north in Kenya." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:OBI_0000925 a rdfs:Class ;
rdfs:label "Infectious Agent" ;
rdfs:comment "A material entity bearing the disposition to infect an organism" ;
rdfs:subClassOf obo:SCDO_0000435 .
obo:SCDO_1000498 a rdfs:Class ;
rdfs:label "Yes-No Question" ;
rdfs:comment "A dichotomous question that has answer options \"yes\" and \"no\"." ;
rdfs:subClassOf obo:SCDO_1000494 .
obo:SCDO_1000751 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Total Hemoglobin Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the total concentration of hemoglobin in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000978 a rdfs:Class ;
rdfs:label "Rehabilitation" ;
rdfs:comment "Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury." ;
rdfs:subClassOf obo:SCDO_0001129 .
obo:HP_0025636 a rdfs:Class ;
rdfs:label "Endometritis" ;
rdfs:comment "Inflammation of the inner lining of the uterus" ;
rdfs:subClassOf obo:HP_0000078 .
obo:NCIT_C82909 a rdfs:Class ;
rdfs:label "Mild Anemia" ;
rdfs:comment "Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%." ;
rdfs:subClassOf obo:HP_0001903 .
obo:NCIT_C519 a rdfs:Class ;
rdfs:label "Gentamicin" ;
rdfs:comment "A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses." ;
rdfs:subClassOf obo:NCIT_C258 .
obo:SCDO_1000768 a rdfs:Class ;
rdfs:label "Acide" ;
rdfs:subClassOf obo:SCDO_1000577 .
obo:SCDO_1000470 a rdfs:Class ;
rdfs:label "SickleInAfrica Participant Number" ;
rdfs:comment "A unique identifier assigned to a study participant's data when it is registered in the SickleInAfrica data registry." ;
rdfs:subClassOf obo:NCIT_C69256 .
obo:SCDO_0000344 a rdfs:Class ;
rdfs:label "Delta Thalassemia" ;
rdfs:comment "A hereditary disorder characterized by reduced or absent delta-globin thus effecting the level of hemoglobin A2, a minor component of adult hemoglobin monitored in the diagnosis of beta-thalassemia." ;
rdfs:subClassOf obo:NCIT_C35069 .
obo:SCDO_1000884 a rdfs:Class ;
rdfs:label "Next of Kin Telephone Number" ;
rdfs:comment "The telephone number of a respondent's next of kin." ;
rdfs:subClassOf obo:NCIT_C40978 .
obo:SCDO_1000422 a rdfs:Class ;
rdfs:label "Basic Element of a Consent Form" ;
rdfs:comment "An element or information entity that is required to be provided in consent forms." ;
rdfs:subClassOf obo:SCDO_0007597 .
obo:HP_0008404 a rdfs:Class ;
rdfs:label "Nail Dystrophy" ;
rdfs:comment "Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate." ;
rdfs:subClassOf obo:HP_0001574 .
obo:NCIT_C93407 a rdfs:Class ;
rdfs:label "Study Outcome Measurement" ;
rdfs:comment "Specific key measurement(s) or observation(s) used to measure the effect of experimental variables on the subjects in a study, or for observational studies, to describe patterns of diseases or traits or associations with exposures, risk factors or treatment. The specific measure that receives the most emphasis in assessment." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0009117 a rdfs:Class ;
rdfs:label "Folate Deficiency" ;
rdfs:comment "A nutritional condition produced by a deficiency of folic acid in the diet." ;
rdfs:subClassOf obo:SCDO_1000261 .
obo:SCDO_1000319 a rdfs:Class ;
rdfs:label "Cigarette Smoking Status Diagnostic Instrument" ;
rdfs:comment "Questions asking the respondent about smoking status in his or her entire life." ;
rdfs:subClassOf obo:SCDO_1000033 .
obo:NCIT_C38060 a rdfs:Class ;
rdfs:label "Eye Examination" ;
rdfs:comment "A test performed by an ophthalmologist or optometrist assessing vision and ability to focus on and discern objects, as well as other tests and examinations pertaining to the eyes." ;
rdfs:subClassOf obo:SCDO_0000898 .
obo:SCDO_0001105 a rdfs:Class ;
rdfs:label "Steroid-Resistant Nephrotic Syndrome" ;
rdfs:comment "A form of nephrotic syndrome that does not respond to treatment with steroid medication after 8 weeks, specifically in children." ;
rdfs:subClassOf obo:SCDO_0000796 .
obo:SCDO_0000162 a rdfs:Class ;
rdfs:label "Breakthrough Pain" ;
rdfs:comment "An episode of severe pain that occurs with rapid onset even when pain-control medication is being used. Breakthrough pain can occur spontaneously or in relation to a specific activity, and can last from a few seconds to a few hours." ;
rdfs:subClassOf obo:SCDO_0000233 .
obo:SCDO_1000728 a rdfs:Class ;
rdfs:label "Carboxyhemoglobin to Total Hemoglobin Ratio" ;
rdfs:comment "The ratio of carboxyhemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage." ;
rdfs:subClassOf obo:CMO_0000508 .
obo:SCDO_1000600 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Malaria Prophylaxis Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether the respondent is using malaria chemoprophylaxis (drugs that prevent malaria)." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000556 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Date of Diagnosis Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's date of diagnosis in the format dd/mm/yyyy." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000162 a rdfs:Class ;
rdfs:label "deprecated-Symptomatic Sickle Cell Trait" ;
rdfs:comment "The condition in which an individual with sickle cell trait shows symptoms of sickle cell disease such as anemia or acute chest syndrome." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000069 a rdfs:Class ;
rdfs:label "APOL1" ;
rdfs:comment "This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Variants in the APOL1 gene can influence susceptibility to end-stage renal disease and Trypanosomiasis (African Sleeping Sickness)." ;
rdfs:subClassOf obo:SCDO_0000810 .
obo:SCDO_0002674 a rdfs:Class ;
rdfs:label "Abnormality of Metabolism/Homeostasis" ;
rdfs:comment "An abnormality of the body's metabolism or homeostasis." ;
rdfs:subClassOf obo:HP_0000118 , obo:MP_0005376 .
obo:SCDO_1000582 a rdfs:Class ;
rdfs:label "Blood Type A Positive" ;
rdfs:comment "A blood type containing type A red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." ;
rdfs:subClassOf obo:HP_0032224 .
obo:SCDO_0001008 a rdfs:Class ;
rdfs:label "Retinal Detachment" ;
rdfs:comment "Separation of the retina from the choroid and eye wall due to holes in the retina and traction on the retina by vitreous bands and condensed preretinal membranes (usually as sequelae of proliferative sickle retinopathy). Retinal detachment is the most severe complication (Stage V) of proliferative sickle retinopathy." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:CMO_0000195 a rdfs:Class ;
rdfs:label "Blood Flow Measurement" ;
rdfs:comment "Any measurement of the movement of blood through the heart and blood vessels." ;
rdfs:subClassOf obo:CMO_0000001 .
obo:SCDO_0000877 a rdfs:Class ;
rdfs:label "PedsQL Multidimensional Fatigue Scale" ;
rdfs:comment "A generic symptom-specific instrument to measure fatigue across pediatric populations." ;
rdfs:subClassOf obo:NCIT_C78652 .
obo:HP_0000005 a rdfs:Class ;
rdfs:label "Mode of Inheritance" ;
rdfs:comment "The pattern in which a particular genetic trait or disorder is passed from one generation to the next." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_0000416 a rdfs:Class ;
rdfs:label "Electrocardiographic Monitor" ;
rdfs:comment "Device which makes prolonged electrocardiographic recordings on a portable tape recorder (Holter-type system) or solid-state device (real-time system), while the patient undergoes normal daily activities; useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_0001253 a rdfs:Class ;
rdfs:label "X-Rays" ;
rdfs:comment "Penetrating, high-energy electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the gamma rays wavelength range. The distinction between gamma rays and X-rays is based on their radiation source." ;
rdfs:subClassOf obo:OBI_0001138 .
obo:SCDO_0300007 a rdfs:Class ;
rdfs:label "Parental Notification" ;
rdfs:comment "Reporting to parents or guardians about care to be provided to a minor (minors)." ;
rdfs:subClassOf obo:SCDO_0300006 .
obo:SCDO_0000945 a rdfs:Class ;
rdfs:label "Pulse Oximetry (Rest)" ;
rdfs:comment "The application of pulse oximetry to measure a patient's saturation of oxyhemoglobin when the patient is at rest." ;
rdfs:subClassOf obo:NCIT_C38085 .
obo:SCDO_0000232 a rdfs:Class ;
rdfs:label "Chronic Restrictive Lung Disease" ;
rdfs:comment "Restrictive lung disease is a category of extrapulmonary, pleural, or parenchymal respiratory diseases that restrict lung expansion, resulting in a decreased lung volume, an increased work of breathing, and inadequate ventilation and/or oxygenation. Pulmonary function test demonstrates a decrease in the forced vital capacity." ;
rdfs:subClassOf obo:HP_0002086 , obo:SCDO_0000954 , obo:SCDO_0001334 .
obo:SCDO_0000598 a rdfs:Class ;
rdfs:label "Hypnotics and Sedatives" ;
rdfs:comment "Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001129 .
obo:SCDO_1000814 a rdfs:Class ;
rdfs:label "Normal Carboxyhemoglobin Level" ;
rdfs:comment "When the level of carboxyhemoglobin detected in a sample of blood falls in the normal range for carboxyhemoglobin." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_0001212 a rdfs:Class ;
rdfs:label "Urine Albumin-Creatinine Ratio" ;
rdfs:comment "A comparison of urine microalbumin, that is, a level of albumin in the urine which is above normal but not detectable with routine protein testing, to the amount of creatinine in a specified volume of urine. Often expressed as albumin concentration divided by creatinine concentration times 1000 mg per gram." ;
rdfs:subClassOf obo:SCDO_0001207 .
obo:SCDO_0001240 a rdfs:Class ;
rdfs:label "Western Blot" ;
rdfs:comment "Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes." ;
rdfs:subClassOf obo:SCDO_0000424 .
obo:SCDO_0000441 a rdfs:Class ;
rdfs:label "General Health Questionnaire (GHQ)" ;
rdfs:comment "The GHQ is a screening device for identifying minor psychiatric disorders in the general population and within community or non-psychiatric clinical settings such as primary care or general medical outpatients. Suitable for all ages from adolescent upwards (not children), it assesses the respondent's current state and asks if that differs from his or her usual state. It is therefore sensitive to short-term psychiatric disorders but not to long-standing attributes of the respondent. The self-administered questionnaire focuses on two major areas: inability to carry out normal functions; appearance of new and distressing phenomena. It is available in the following versions: GHQ-60 -- the fully detailed 60-item questionnaire; GHQ-30 -- a short form without items relating to physical illness; GHQ-28 -- a 28 item scaled version -- assesses somatic symptoms, anxiety and insomnia, social dysfunction and severe depression; GHQ-12 -- quick, reliable and sensitive short form, ideal for research studies." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:HP_0012638 a rdfs:Class ;
rdfs:label "Abnormal Nervous System Physiology" ;
rdfs:comment "A functional anomaly of the nervous system." ;
rdfs:subClassOf obo:HP_0000707 .
obo:NCIT_C122931 a rdfs:Class ;
rdfs:label "Imaging Transcranial Doppler Ultrasonography" ;
rdfs:comment "A diagnostic technique that uses pulsed Doppler ultrasound to both identify blood vessels in the brain and measure the velocity of blood flow through those vessels. It allows a more accurate estimation of stroke risk because it allows outlining of parenchymal structures and visualization of the examined vessels." ;
rdfs:subClassOf obo:NCIT_C154865 , obo:NCIT_C17230 .
obo:SCDO_1000571 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Month of Diagnosis Question" ;
rdfs:comment "The Sickle in Africa core data element that records the month of the year in which the respondent was diagnosed with SCD." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:UO_0000015 a rdfs:Class ;
rdfs:label "Centimeter" ;
rdfs:comment "A length unit which is equal to one hundredth of a meter or 10^[-2] m." ;
rdfs:subClassOf obo:UO_0000001 .
obo:SCDO_0000086 a rdfs:Class ;
rdfs:label "Asthma" ;
rdfs:comment "A form of bronchial disorder with three distinct components: airway hyper-responsiveness, airway inflammation, and intermittent airway obstruction. It is characterized by spasmodic contraction of airway smooth muscle, wheezing and dyspnea." ;
rdfs:subClassOf obo:HP_0002086 , obo:SCDO_0000954 .
obo:SCDO_0000216 a rdfs:Class ;
rdfs:label "Chemical Assay" ;
rdfs:comment "The analysis of a sample material, called an analyte, using a set of chemical procedures." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:SCDO_0001041 a rdfs:Class ;
rdfs:label "Seroepidemiologic Studies" ;
rdfs:comment "Epidemiologic studies based on the detection through serological testing of characteristic change in the serum level of specific antibodies. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_0000496 a rdfs:Class ;
rdfs:label "Healthcare Access" ;
rdfs:comment "The ease with which an individual can obtain needed medical services." ;
rdfs:subClassOf obo:SCDO_0000948 .
obo:HP_0011873 a rdfs:Class ;
rdfs:label "Abnormal Platelet Count" ;
rdfs:comment "Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood." ;
rdfs:subClassOf obo:HP_0001872 .
obo:OPMI_0000025 a rdfs:Class ;
rdfs:label "Do Not Know" ;
rdfs:comment "An answer to question that indicates the response to the specified question is unknown." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_0000296 a rdfs:Class ;
rdfs:label "Creatinine Blood Test" ;
rdfs:comment "A bioassay to measure the serum concentration of creatinine, a metabolite of muscle creatine that is filtered out of blood by the kidneys." ;
rdfs:subClassOf obo:SCDO_0000133 , obo:SCDO_0000676 .
obo:SCDO_1000820 a rdfs:Class ;
rdfs:label "Hematopoietic System Phenotype" ;
rdfs:comment "The observable morphological and physiological characteristics of the human blood cells or the organs associated with the development and formation of blood cells that are manifested through development and lifespan." ;
rdfs:subClassOf obo:OGMS_0000023 .
obo:SCDO_1000882 a rdfs:Class ;
rdfs:label "Telephone Number 1" ;
rdfs:comment "A respondent's primary telephone number." ;
rdfs:subClassOf obo:NCIT_C40978 .
obo:SCDO_0001122 a rdfs:Class ;
rdfs:label "Suicidal Thoughts" ;
rdfs:comment "Frequent thinking about or preoccupation with killing oneself." ;
rdfs:subClassOf obo:SCDO_0000360 .
obo:NCIT_C63547 a rdfs:Class ;
rdfs:label "Haplotype" ;
rdfs:comment "A way of denoting the collective genotype of a number of closely linked loci on a chromosome." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_0002337 a rdfs:Class ;
rdfs:label "Ethical Conduct" ;
rdfs:comment "The abiding by applicable principles such as 1. compliance by research institutions; 2. obtaining and documenting informed consent; 3. Research Ethics Committee membership function, operations, review of research, and record keeping; 4. additional protection for certain vulnerable research subjects - pregnant women, prisoners, and children" ;
rdfs:subClassOf obo:SCDO_1000430 .
obo:HP_0000829 a rdfs:Class ;
rdfs:label "Hypoparathyroidism" ;
rdfs:comment "A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia." ;
rdfs:subClassOf obo:HP_0000828 .
obo:SCDO_0000760 a rdfs:Class ;
rdfs:label "Migraine Questionnaire" ;
rdfs:comment "A questionnaire to assess migraines and headaches." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:HP_0001394 a rdfs:Class ;
rdfs:label "Cirrhosis" ;
rdfs:comment "A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function." ;
rdfs:subClassOf obo:HP_0001392 .
obo:SCDO_1000151 a rdfs:Class ;
rdfs:label "Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care" ;
rdfs:comment "A document that include standards and guidelines for clinical care and recommendations for how care for children with sickle cell disease should be delivered." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_0000657 a rdfs:Class ;
rdfs:label "Intraosseous Pressure" ;
rdfs:comment "The hydrostatic pressure of venous blood in the marrow of bones." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_0000866 a rdfs:Class ;
rdfs:label "Parasite" ;
rdfs:comment "Invertebrate organisms that live on or in another organism (the host), and benefit at the expense of the other. Traditionally excluded from definition of parasites are pathogenic bacteria; fungi; viruses; and plants; though they may live parasitically." ;
rdfs:subClassOf obo:OBI_0000925 .
obo:SCDO_0001111 a rdfs:Class ;
rdfs:label "Stroke" ;
rdfs:comment "A group of pathological conditions characterized by sudden loss of neurological function due to brain ischemia or intracranial hemorrhages. Stroke is classified by the type of tissue necrosis, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature." ;
rdfs:subClassOf obo:SCDO_0000954 , obo:SCDO_1000037 .
obo:SCDO_1000895 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Chest Pain Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether a participant has chest pain." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000318 a rdfs:Class ;
rdfs:label "Diagnostic Instrument Measurement" ;
rdfs:comment "An information entity, used in the diagnosis of medical conditions, that is a recording of the output of a diagnostic instrument." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:SCDO_0001075 a rdfs:Class ;
rdfs:label "Sleep Breathing Disorder" ;
rdfs:comment "An intrinsic sleep disorder characterized by breathing abnormalities." ;
rdfs:subClassOf obo:HP_0000708 .
obo:DOID_9220 a rdfs:Class ;
rdfs:label "Central Sleep Apnea" ;
rdfs:comment "A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing." ;
rdfs:subClassOf obo:HP_0000708 .
obo:SCDO_1000854 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hospital Name Question" ;
rdfs:comment "The Sickle in Africa core data element that records the name of the hospital that a patient visited." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0008688 a rdfs:Class ;
rdfs:label "Biobank" ;
rdfs:comment "A biobank is a collections of samples of biological substances (e.g. tissue, blood, DNA) which are linked to data about the samples and their donors. They have a dual nature as collections of samples and data and usually require investigators or institutions to agree to certain conditions as a condition for sharing samples or data with them." ;
rdfs:subClassOf obo:SCDO_0300003 .
obo:SCDO_0001086 a rdfs:Class ;
rdfs:label "Social Role Fulfillment" ;
rdfs:comment "An extent/ degree to which an individual fulfills the expectations of his/her social role." ;
rdfs:subClassOf obo:SCDO_0001083 .
obo:SCDO_0000542 a rdfs:Class ;
rdfs:label "obsolete - Hemoglobin M Trait" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:NCIT_C15320 a rdfs:Class ;
rdfs:label "Study Design" ;
rdfs:comment "A plan detailing how a study will be performed in order to represent the phenomenon under examination, to answer the research questions that have been asked, and defining the methods of data analysis. Study design is driven by research hypothesis being posed, study subject/population/sample available, logistics/resources: technology, support, networking, collaborative support, etc." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:HP_0012574 a rdfs:Class ;
rdfs:label "Mesangial Hypercellularity" ;
rdfs:comment "Increased numbers of mesangial cells per glomerulus, defined as four or more nuclei in a peripheral mesangial segment." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_1000538 a rdfs:Class ;
rdfs:label "Diagnosis Temporal Observable" ;
rdfs:comment "Time-related information that can be observed and is related to a diagnosis." ;
rdfs:subClassOf obo:SCDO_1000537 , obo:SCDO_1000553 .
obo:SCDO_0000054 a rdfs:Class ;
rdfs:label "Angioid Streaks" ;
rdfs:comment "Grayish, brown, or dark red streaks caused by cracks in Bruch's membrane that are histologically characterized by calcium deposition. Angioid streaks are most characteristic of sickle cell anemia and can occur to a lesser extent in other sickle cell syndromes, but not in sickle cell trait." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:CHEBI_7852 a rdfs:Class ;
rdfs:label "Oxycodone" ;
rdfs:comment "A semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine." ;
rdfs:subClassOf obo:CHEBI_35482 .
obo:NCIT_C41129 a rdfs:Class ;
rdfs:label "deprecated Region" ;
rdfs:comment "An area or portion of something with more or less definite boundaries designed or specified according to some established biological, administrative, economic, demographic, etc. criteria." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000887 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Units Transfused Question" ;
rdfs:comment "The Sickle in Africa core data element that records the number of units of blood that a participant was given during a blood transfusion." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:NCIT_C75434 a rdfs:Class ;
rdfs:label "Hemoglobin Subunit Alpha" ;
rdfs:comment "Hemoglobin subunit alpha (142 aa, ~15 kDa) is encoded by both the human HBA1 and human HBA2 genes. This protein plays a role in the distribution of oxygen from the lungs to other organs and tissues." ;
rdfs:subClassOf obo:SCDO_1000105 .
obo:SCDO_1000860 a rdfs:Class ;
rdfs:label "Middle Name" ;
rdfs:comment "A middle name is a name assigned to an individual that is not the first or last name." ;
rdfs:subClassOf obo:NCIT_C25191 .
obo:SCDO_0000781 a rdfs:Class ;
rdfs:label "Mutation Carrier Screening" ;
rdfs:comment "The process of identifying carriers/heterozygotes of a genetic mutation that can result in a severe recessive condition. Carrier screening is done using various laboratory techniques." ;
rdfs:subClassOf obo:NCIT_C92803 .
obo:SCDO_0000187 a rdfs:Class ;
rdfs:label "deprecated Cardiovascular System" ;
rdfs:comment "'Anatomical system that has as its parts the heart and blood vessels. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:HP_0001658 a rdfs:Class ;
rdfs:label "Myocardial Infarction" ;
rdfs:comment "Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_0000221 a rdfs:Class ;
rdfs:label "Children's Health Locus of Control Scale (CHLC)" ;
rdfs:comment "A measure that seeks to determine the extent to which children and adolescents believe their own health-related behaviors will influence their health. It is a 20 item scale that contains 3 additional practice items and is a yes or no format. It contains 3 factors: belief in internality, belief in powerful others and belief in chance. There is a shorter 9-item version of the scale which is comparable to the full version and adapted for use in Egyptian children." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:SCDO_1000397 a rdfs:Class ;
rdfs:label "Gene Promoter" ;
rdfs:comment "A gene promoter is a region of DNA that initiates transcription of a particular gene." ;
rdfs:subClassOf obo:SCDO_1000395 .
obo:NCIT_C3439 a rdfs:Class ;
rdfs:label "Viral Infection" ;
rdfs:comment "Any disease caused by a virus." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:SCDO_1000137 a rdfs:Class ;
rdfs:label "Maragoli" ;
rdfs:comment "It is the second largest sub-tribe of the Luhya ethnic group in Kenya." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000896 a rdfs:Class ;
rdfs:label "Physical Detection Method" ;
rdfs:comment "The physical method (technology) used to measure / readout the effect caused by a perturbagen in the assay environment." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:SCDO_1000042 a rdfs:Class ;
rdfs:label "HBB, GLU26LYS" ;
rdfs:comment "A mutation in the HBB gene causing substitution of glutamic acid for lysine at the 26th position of the beta-globin chain." ;
rdfs:subClassOf obo:SCDO_0001765 , obo:SCDO_0009786 .
obo:SCDO_1000549 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Date of Transfusion Question" ;
rdfs:comment "The Sickle in Africa core data element that records the date on which the respondent last received a blood transfusion." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000333 a rdfs:Class ;
rdfs:label "D57.812 Other sickle-cell disorders with splenic sequestration" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000331 .
obo:SCDO_1000065 a rdfs:Class ;
rdfs:label "Specific Consent" ;
rdfs:comment "Requires that consent to the use of human samples be specific to the 'purpose' for which the sample is to be used and that where previously collected samples are to be used for a different 'research purpose' further consent should generally be obtained." ;
rdfs:subClassOf obo:SCDO_0007087 .
obo:SCDO_1000650 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Urinary Creatinine Concentration Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the concentration of creatinine in the respondent's urine." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0000505 a rdfs:Class ;
rdfs:label "Visual Impairment" ;
rdfs:comment "Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:SCDO_0008251 a rdfs:Class ;
rdfs:label "Homozygous Deletion of HBA1" ;
rdfs:comment "Deletion of both HBA1 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia." ;
rdfs:subClassOf obo:SCDO_0001386 .
obo:SCDO_1000025 a rdfs:Class ;
rdfs:label "obsolete PCS (published clinical study)" ;
rdfs:comment "'This should be used for information extracted from articles in the medical literature. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:MP_0009642 a rdfs:Class ;
rdfs:label "Abnormal Blood Homeostasis" ;
rdfs:comment "Anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood." ;
rdfs:subClassOf obo:HP_0001871 , obo:SCDO_0002674 .
obo:HP_0009045 a rdfs:Class ;
rdfs:label "Exercise-Induced Rhabdomyolysis" ;
rdfs:comment "Rhabdomyolysis induced by exercise." ;
rdfs:subClassOf obo:SCDO_1000260 .
obo:SCDO_1000847 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Type of Visit Question" ;
rdfs:comment "The Sickle in Africa core data element that records the type of visit undertaken by a patient." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000871 a rdfs:Class ;
rdfs:label "Street Name" ;
rdfs:comment "A street name is the token given to identify a particular street." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_0000457 a rdfs:Class ;
rdfs:label "Glomerular Filtration Rate" ;
rdfs:comment "Measurement of the flow rate of filtered fluid through the kidney, calculated either by comparative measurements of substances in the blood and urine, or estimated from a blood test." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:HP_0003611 a rdfs:Class ;
rdfs:label "Dyslipidemia" ;
rdfs:comment "Anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood." ;
rdfs:subClassOf obo:MP_0002118 .
obo:CMO_0000011 a rdfs:Class ;
rdfs:label "Whole Body Morphological Measurement" ;
rdfs:comment "Morphological measurement involving the entire body of an organism." ;
rdfs:subClassOf obo:CMO_0000021 .
obo:SCDO_1000784 a rdfs:Class ;
rdfs:label "Absent Hemoglobin S" ;
rdfs:comment "A lack of production of hemoglobin S." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_0000517 a rdfs:Class ;
rdfs:label "Hemoglobin Barts" ;
rdfs:comment "An abnormal hemoglobin, composed of four gamma globin chains, causing it to have an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues." ;
rdfs:subClassOf obo:SCDO_0003807 .
obo:SCDO_1000444 a rdfs:Class ;
rdfs:label "Serum L-Selectin Level" ;
rdfs:comment "The level of L-selectin in the systemic circulation (serum)." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:HP_0001923 a rdfs:Class ;
rdfs:label "Reticulocytosis" ;
rdfs:comment "An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation." ;
rdfs:subClassOf obo:HP_0004312 .
obo:SCDO_1000586 a rdfs:Class ;
rdfs:label "Blood Type O Positive" ;
rdfs:comment "A blood type containing no surface markers on red blood cells, with the presence of a protein called rhesus (Rh) factor." ;
rdfs:subClassOf obo:HP_0032224 .
obo:SCDO_0000254 a rdfs:Class ;
rdfs:label "obsolete Clinical Trial" ;
rdfs:comment "'A work that reports on the results of a clinical study in which participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Participants may receive diagnostic, therapeutic, or other types of interventions. While most clinical trials concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000252 .
obo:SCDO_1000187 a rdfs:Class ;
rdfs:label "Normal Hemoglobin A2 Level" ;
rdfs:comment "When the level of hemoglobin A2 detected in a sample of blood falls in the normal range for HbA2." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_0001376 a rdfs:Class ;
rdfs:label "deprecated beta E mutation" ;
rdfs:comment "'To be defined by an expert [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0005305 a rdfs:Class ;
rdfs:label "Cerebral Venous Thrombosis" ;
rdfs:comment "Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow." ;
rdfs:subClassOf obo:HP_0001977 , obo:HP_0002060 .
obo:SCDO_0000125 a rdfs:Class ;
rdfs:label "Birthplace of Biological Mother" ;
rdfs:comment "The country in which the respondent's biological mother was born." ;
rdfs:subClassOf obo:SCDO_0000129 .
obo:SCDO_1000106 a rdfs:Class ;
rdfs:label "Sickle Cell Disease" ;
rdfs:comment """Sickle cell disease (SCD) is a pleiotropic inherited disorder of the blood, characterised by the appearance of sickle-shaped red blood cells and anemia. It results from homozygosity for the sickle beta-globin gene mutation at position 6 (glu > val), or compound heterozygosity for the sickle gene and either another mutation for a different hemoglobin variant or one of numerous beta-thalassemia
mutations.""" ;
rdfs:subClassOf obo:SCDO_0000552 .
obo:SCDO_0006909 a rdfs:Class ;
rdfs:label "Hyper-Hemolytic Crisis" ;
rdfs:comment "Significant change in blood picture characterised by a precipitous fall in the haemoglobin level associated with jaundice, marked reticulocytosis, and polychromasia on the blood smear, increased unconju- gated hyperbilirubinaemia, and increased urobilinogen content in urine above the steady state level for each individual patient." ;
rdfs:subClassOf obo:SCDO_0004187 .
obo:SCDO_0000706 a rdfs:Class ;
rdfs:label "obsolete Lymphoid System" ;
rdfs:comment "'The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000697 a rdfs:Class ;
rdfs:label "Hemoglobin E Level" ;
rdfs:comment "The amount of hemoglobin E present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:SCDO_1000876 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Telephone 1 Question" ;
rdfs:comment "The Sickle in Africa core data element that records the participant's primary telephone number." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000205 a rdfs:Class ;
rdfs:label "Hemoglobin C-Harlem Disease" ;
rdfs:comment "A clinically severe form of sickle cell disease resulting when a person is homozygous for Hemoglobin C-Harlem." ;
rdfs:subClassOf obo:SCDO_0008262 .
obo:SCDO_0000528 a rdfs:Class ;
rdfs:label "Hemoglobin D-Punjab" ;
rdfs:comment "An abnormal hemoglobin (one of the types of hemoglobin D) in which glutamine replaces glutamic acid at codon 121 of beta globin." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_1000007 .
obo:SCDO_0000114 a rdfs:Class ;
rdfs:label "Beta Thalassemia Trait" ;
rdfs:comment "The inheritance of only one mutated beta-globin allele (beta+ or beta0)." ;
rdfs:subClassOf obo:SCDO_0000251 , obo:SCDO_0000551 .
obo:HP_0002164 a rdfs:Class ;
rdfs:label "Nail Dysplasia" ;
rdfs:comment "The presence of developmental dysplasia of the nail." ;
rdfs:subClassOf obo:HP_0001574 .
obo:SCDO_1000086 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S/Quebec Chori" ;
rdfs:comment "A severe compound heterozygous sickling disorder characterized by the presence of both hemoglobin S and hemoglobin Quebec Chori." ;
rdfs:subClassOf obo:SCDO_1000163 .
obo:NCIT_C16809 a rdfs:Class ;
rdfs:label "Magnetic Resonance Imaging" ;
rdfs:comment "Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders." ;
rdfs:subClassOf obo:OBI_0000185 .
obo:NCIT_C95534 a rdfs:Class ;
rdfs:label "Hemoglobin Trait" ;
rdfs:comment "A condition in which a person is heterozygous for a globin gene, with one normal allele and one defective allele." ;
rdfs:subClassOf obo:SCDO_0000552 .
obo:SCDO_1000031 a rdfs:Class ;
rdfs:label "from personal attribute" ;
rdfs:comment "Terms deprecated in the \"Personal Attribute\" class." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000426 a rdfs:Class ;
rdfs:label "Communicable Disease - Report by Law Statement" ;
rdfs:comment "A statement about how the researcher is obligated by law to report if the participant is found to have a communicable disease." ;
rdfs:subClassOf obo:SCDO_1000422 .
obo:SCDO_1000071 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype A/Jamaica Plain" ;
rdfs:comment "A genotype that involves a double mutation in one beta-globin gene that results in hemoglobin with low oxygen affinity, which results in the polymerisation of the hemoglobin variant (hemoglobin Jamaica Plain) and thus sickling of erythorcytes." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:MP_0013305 a rdfs:Class ;
rdfs:label "Isosthenuria" ;
rdfs:comment "Inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake." ;
rdfs:subClassOf obo:HP_0004727 .
obo:SCDO_0000391 a rdfs:Class ;
rdfs:label "Disease Modifier" ;
rdfs:comment "A factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_1000795 a rdfs:Class ;
rdfs:label "D57.438 Sickle-cell thalassemia beta zero with crisis with other specified complication" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000791 .
obo:SCDO_0000739 a rdfs:Class ;
rdfs:label "Medication Adherence" ;
rdfs:comment "Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency." ;
rdfs:subClassOf obo:SCDO_0000869 .
obo:SCDO_1000324 a rdfs:Class ;
rdfs:label "Current Some-Day Smoker" ;
rdfs:comment "A person who had smoked a cigarette in the past, and was smoking on some days, but not daily, at the time of the interview." ;
rdfs:subClassOf obo:SCDO_0000235 .
obo:SCDO_1000392 a rdfs:Class ;
rdfs:label "Sp1 Transcription Factor" ;
rdfs:comment "Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES." ;
rdfs:subClassOf obo:NCIT_C26548 .
obo:SCDO_0000983 a rdfs:Class ;
rdfs:label "Renal Dialysis" ;
rdfs:comment "Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, peritoneal dialysis, and hemodiafiltration." ;
rdfs:subClassOf obo:SCDO_1000004 .
obo:SCDO_1000307 a rdfs:Class ;
rdfs:label "Hepatitis C Antibody Test" ;
rdfs:comment "A determination of the presence of the hepatitis C virus antibody in a biological specimen." ;
rdfs:subClassOf obo:SCDO_0000616 .
obo:CMO_0002079 a rdfs:Class ;
rdfs:label "Birth Weight" ;
rdfs:comment "The heaviness or degree to which the entire body of an organism at the point of or shortly after birth is drawn to the earth by gravity." ;
rdfs:subClassOf obo:SCDO_0000152 .
obo:SCDO_0000107 a rdfs:Class ;
rdfs:label "Beliefs About Causes of Illness" ;
rdfs:comment "Personal or collective understanding of what the causes (could be predisposing factors, enabling factors, precipitating factors, reinforcing factors, and/or risk factors) are of a certain illness." ;
rdfs:subClassOf obo:SCDO_0000488 .
obo:SCDO_1000604 a rdfs:Class ;
rdfs:label "Management Details Added By" ;
rdfs:comment "The person who recorded the information about how a patient's condition is being managed." ;
rdfs:subClassOf obo:SCDO_1000590 .
obo:CMO_0000291 a rdfs:Class ;
rdfs:label "Mean Corpuscular Hemoglobin Concentration" ;
rdfs:comment "The amount of hemoglobin in a given volume of packed red blood cells and is often calculated by dividing the hemoglobin concentration by the hematocrit." ;
rdfs:subClassOf obo:CMO_0001356 .
obo:SCDO_0001604 a rdfs:Class ;
rdfs:label "Steady State" ;
rdfs:comment "That period when the patient with sickle cell anaemia is free of infection, pain, or other disease processes." ;
rdfs:subClassOf obo:SCDO_0000895 .
obo:SCDO_0000493 a rdfs:Class ;
rdfs:label "Health Service Utilization" ;
rdfs:comment "The measure of the population's use of the health care services available to them. This includes the utilization of hospital resources, Personal Care Home (PCH) resources, and physician resources. Health care utilization and health status are used to examine how efficiently a health care system produces health in a population." ;
rdfs:subClassOf obo:SCDO_0000948 .
obo:HP_0002659 a rdfs:Class ;
rdfs:label "Bone Fragility" ;
rdfs:comment "An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture." ;
rdfs:subClassOf obo:HP_0000924 .
obo:NCIT_C28407 a rdfs:Class ;
rdfs:label "National Origin" ;
rdfs:comment "System of classification based on nation from which a person originates, regardless of the nation in which he/she currently resides." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0001090 .
obo:SCDO_1000255 a rdfs:Class ;
rdfs:label "Guidelines on Red Cell Transfusion in Sickle Cell Disease - Part II: Indications for Transfusion" ;
rdfs:comment "Guidelines that examine current available evidence on indications for transfusion in sickle cell disease." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:NCIT_C64572 a rdfs:Class ;
rdfs:label "microgram per millilitre" ;
rdfs:comment "A metric unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one cubic meter. The concept also refers to the metric unit of mass density (volumic mass) defined as the density of a substance which mass equal to one gram occupies the volume of one cubic meter." ;
rdfs:subClassOf obo:UO_0000180 .
obo:SCDO_1000060 a rdfs:Class ;
rdfs:label "SCD Molecular Phenotype" ;
rdfs:comment "The underlying molecular makeup resulting in sickle cell disease." ;
rdfs:subClassOf obo:SCDO_0007623 .
obo:SCDO_0000728 a rdfs:Class ;
rdfs:label "Diagnostic Measurement" ;
rdfs:comment "An information entity used in the diagnosis of medical conditions. It could be the recording of the output of a diagnostic device or the outcome of a diagnostic tool." ;
rdfs:subClassOf obo:SCDO_0000379 .
obo:SCDO_1000724 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Oxyhemoglobin Saturation Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's arterial oxygen saturation (oxyhemoglobin saturation), as measured by an arterial blood gas test." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:CHEBI_35482 a rdfs:Class ;
rdfs:label "Opioid" ;
rdfs:comment "A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood." ;
rdfs:subClassOf obo:SCDO_0000050 .
obo:SCDO_0000754 a rdfs:Class ;
rdfs:label "deprecated Diagnostic Method" ;
rdfs:comment "'Any procedure or test to diagnose a disease or disorder. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000034 .
obo:SCDO_0008778 a rdfs:Class ;
rdfs:label "Dental Radiograph" ;
rdfs:comment "A radiograph of dental structures made on x-ray film or stored as a digital image. The radiographs may be extraoral or intraoral. Three common types of intraoral dental images are periapical, interproximal, and occlusal radiographs." ;
rdfs:subClassOf obo:SCDO_0000963 .
obo:HP_0045048 a rdfs:Class ;
rdfs:label "Increased Hemoglobin A2" ;
rdfs:comment "An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia." ;
rdfs:subClassOf obo:HP_0020063 , obo:SCDO_1000061 .
obo:SCDO_1000831 a rdfs:Class ;
rdfs:label "Normal Serum Aspartate Aminotransferase" ;
rdfs:comment "When the level of serum aspartate aminotransferase is in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:SCDO_1000900 a rdfs:Class ;
rdfs:label "First Visit" ;
rdfs:comment "A clinical visit that is the patient's first clinical visit." ;
rdfs:subClassOf obo:NCIT_C103165 .
obo:SCDO_0000539 a rdfs:Class ;
rdfs:label "Hemoglobin Lepore Trait" ;
rdfs:comment "The inheritance of the gene for hemoglobin Lepore from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ;
rdfs:subClassOf obo:SCDO_0000551 .
obo:SCDO_1000452 a rdfs:Class ;
rdfs:label "Cancer Pain" ;
rdfs:comment "Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during neoplasm growth, tissue invasion, and metastasis." ;
rdfs:subClassOf obo:SCDO_0000851 .
obo:HP_0005162 a rdfs:Class ;
rdfs:label "Left Ventricular Dysfunction" ;
rdfs:comment "Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole." ;
rdfs:subClassOf obo:HP_0011025 .
obo:HP_0020062 a rdfs:Class ;
rdfs:label "Decreased Hemoglobin Concentration" ;
rdfs:comment "An abnormal reduction below normal hemoglobin concentration in the circulation." ;
rdfs:subClassOf obo:HP_0020061 .
obo:SCDO_1000308 a rdfs:Class ;
rdfs:label "Hepatitis C Virus Core Antigen Test" ;
rdfs:comment "The determination of the amount of hepatitis C virus core antigen in a biological sample." ;
rdfs:subClassOf obo:SCDO_1000306 .
obo:SCDO_0001055 a rdfs:Class ;
rdfs:label "Sickle Cell Trait" ;
rdfs:comment "The condition of being heterozygous for hemoglobin S." ;
rdfs:subClassOf obo:NCIT_C95534 .
obo:SCDO_1000731 a rdfs:Class ;
rdfs:label "SCD Passport Number" ;
rdfs:comment "A unique identifier provided on SCD passports." ;
rdfs:subClassOf obo:NCIT_C69256 .
obo:SCDO_0007656 a rdfs:Class ;
rdfs:label "Sickle Cell Thalassemia" ;
rdfs:comment "Hemolytic anemia, in which patients are compound or double heterozygous for both the sickle cell gene and a thalassemia gene." ;
rdfs:subClassOf obo:SCDO_1000163 , obo:SCDO_1000215 .
obo:SCDO_0001223 a rdfs:Class ;
rdfs:label "Validation Studies" ;
rdfs:comment "Works consisting of research using processes by which the reliability and relevance of a procedure for a specific purpose are established." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0001329 a rdfs:Class ;
rdfs:label "Folic Acid" ;
rdfs:comment "A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0000922 , obo:SCDO_0001133 .
obo:SCDO_1000036 a rdfs:Class ;
rdfs:label "Hemoglobin C Present" ;
rdfs:comment "When the abnormal hemoglobin, hemoglobin C (HbC), has been detected in a blood sample." ;
rdfs:subClassOf obo:HP_0020061 .
obo:SCDO_0000765 a rdfs:Class ;
rdfs:label "Genetic Phenomena" ;
rdfs:comment "The biological processes, properties, and objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_0004576 a rdfs:Class ;
rdfs:label "Chronic Hypersplenism" ;
rdfs:comment "Chronic splenic sequestration associated with enlarged spleen and cytopaenia with anaemia and reduction in white blood cells and platelets. The anaemia is usually chronic in nature and patients rarely present with signs of heart failure." ;
rdfs:subClassOf obo:SCDO_0001334 , obo:SCDO_0006905 .
obo:HP_0000077 a rdfs:Class ;
rdfs:label "Abnormality of the Kidney" ;
rdfs:comment "An abnormality of the kidney." ;
rdfs:subClassOf obo:HP_0000079 .
obo:SCDO_0000311 a rdfs:Class ;
rdfs:label "D57 Sickle-Cell Disorders" ;
rdfs:comment "A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia." ;
rdfs:subClassOf obo:SCDO_0000607 .
obo:SCDO_0000943 a rdfs:Class ;
rdfs:label "Pulmonary Hypertension" ;
rdfs:comment "An elevation of mean pulmonary arterial systolic pressure (mPASP) (>20 mmHg at rest or >30 mmHg with exercise). The 6th World Symposium on PH reduced it from >25mmHg to >20mmHg for at rest, but did not adjust the definition for PH with exercise." ;
rdfs:subClassOf obo:HP_0000822 .
obo:HP_0012229 a rdfs:Class ;
rdfs:label "Cerebrospinal Fluid Pleocytosis" ;
rdfs:comment "An increased white blood cell count in the cerebrospinal fluid." ;
rdfs:subClassOf obo:HP_0002060 .
obo:DUO_0000026 a rdfs:Class ;
rdfs:label "User Specific Restriction" ;
rdfs:comment "This requirement indicates that use is limited to use by approved users." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_1000425 a rdfs:Class ;
rdfs:label "Study Focus Statement" ;
rdfs:comment "A statement of what the key investigational purpose of the study is." ;
rdfs:subClassOf obo:SCDO_1000422 .
obo:SCDO_1000059 a rdfs:Class ;
rdfs:label "Hemoglobin D-Punjab Trait" ;
rdfs:comment "The inheritance of the gene for hemoglobin D-Punjab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ;
rdfs:subClassOf obo:SCDO_0000525 .
obo:SCDO_1000020 a rdfs:Class ;
rdfs:label "Treatment of Precipitating Factors" ;
rdfs:comment "Treatment of factors associated with the definitive onset of a disease, illness, accident, behavioral response, or course of action. Usually one factor is more important or more obviously recognizable than others, if several are involved, and one may often be regarded as necessary. Examples include exposure to specific disease; amount or level of an infectious organism, drug, or noxious agent, etc." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:SCDO_1000361 a rdfs:Class ;
rdfs:label "Alpha-Globin Gene" ;
rdfs:comment "A gene that provides instructions for making a protein called alpha-globin." ;
rdfs:subClassOf obo:SCDO_1000360 .
obo:SCDO_1000047 a rdfs:Class ;
rdfs:label "HBB, LEU68PHE" ;
rdfs:comment "A mutation where the leusine residue in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by phenylalanine. This mutation on its own produces a stable hemoglobin that does not result in hemolysis (Hb Rockford), but when in combination with the Hb S mutation (HBB, GLU6VAL), the symptomatic Hb Jamaica Plain is produced." ;
rdfs:subClassOf obo:SCDO_0009786 .
obo:MP_0001792 a rdfs:Class ;
rdfs:label "Impaired Wound Healing" ;
rdfs:comment "Reduced ability or inability to self-repair and close wounds." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_1000801 a rdfs:Class ;
rdfs:label "D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000798 .
obo:SCDO_1000379 a rdfs:Class ;
rdfs:label "Culturally Competent Care" ;
rdfs:comment "Health care services that are respectful of and responsive to the health beliefs, practices and cultural and linguistic needs of diverse patients. The provider and the patient each bring their individual learned patterns of language and culture to the health care experience which must be transcended to achieve equal access and quality health care." ;
rdfs:subClassOf obo:SCDO_0000246 .
obo:SCDO_0006036 a rdfs:Class ;
rdfs:label "Minor" ;
rdfs:comment "A person who has not attained the age at which full civil rights are accorded." ;
rdfs:subClassOf obo:SCDO_0002125 .
obo:SCDO_0004829 a rdfs:Class ;
rdfs:label "Transient Ischemic Attack" ;
rdfs:comment "Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic)." ;
rdfs:subClassOf obo:HP_0030680 .
obo:OBI_0000185 a rdfs:Class ;
rdfs:label "Imaging Assay" ;
rdfs:comment "An assay that produces a picture of an entity." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:HP_0011906 a rdfs:Class ;
rdfs:label "Reduced Beta/Alpha Synthesis Ratio" ;
rdfs:comment "A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia." ;
rdfs:subClassOf obo:HP_0005560 .
obo:MP_0011471 a rdfs:Class ;
rdfs:label "Decreased Urine Creatinine Level" ;
rdfs:comment "a reduced amount of creatinine in the urine compared to the normal state" ;
rdfs:subClassOf obo:MP_0011469 .
obo:SCDO_1000076 a rdfs:Class ;
rdfs:label "Mild Sickle Cell Disease-S Beta Minus Thalassemia" ;
rdfs:comment "A form of sickle cell thalassemia, with a mild clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." ;
rdfs:subClassOf obo:SCDO_0001056 .
obo:SCDO_0001330 a rdfs:Class ;
rdfs:label "Follow-Up Studies" ;
rdfs:comment "Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease." ;
rdfs:subClassOf obo:SCDO_0000263 .
obo:HP_0012444 a rdfs:Class ;
rdfs:label "Atrophic Brain" ;
rdfs:comment "Partial or complete wasting (loss) of brain tissue that was once present." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_0000198 a rdfs:Class ;
rdfs:label "Cell Free Hemoglobin Blood Test" ;
rdfs:comment "The determination of the amount of free hemoglobin present in a sample." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_0001228 a rdfs:Class ;
rdfs:label "Endothelial Function Test" ;
rdfs:comment "A measure of vascular endothelial cell response to stimulation, for example, by vasoactive substances released by or those that interact with the vascular endothelium." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:HP_0001877 a rdfs:Class ;
rdfs:label "Abnormal Erythrocyte Morphology" ;
rdfs:comment "Any structural abnormality of erythrocytes (red-blood cells)." ;
rdfs:subClassOf obo:HP_0001871 .
obo:HP_0004586 a rdfs:Class ;
rdfs:label "Biconcave Vertebral Bodies" ;
rdfs:comment "Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_0001198 a rdfs:Class ;
rdfs:label "Twin Studies as Topic" ;
rdfs:comment "Works about methods of detecting genetic etiology in human traits. The basic premise of twin studies is that monozygotic twins carry identical genes, while zygotic twins are genetically no more similar than two siblings born after separate pregnancies. (Last, J.M., A Dictionary of Epidemiology, 2d ed)" ;
rdfs:subClassOf obo:SCDO_0300004 .
obo:UO_0000001 a rdfs:Class ;
rdfs:label "Length Unit" ;
rdfs:comment "A unit which is a standard measure of the distance between two points." ;
rdfs:subClassOf obo:UO_0000000 .
obo:HP_0000962 a rdfs:Class ;
rdfs:label "Hyperkeratosis" ;
rdfs:comment "Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum." ;
rdfs:subClassOf obo:HP_0011121 .
obo:CHEBI_35493 a rdfs:Class ;
rdfs:label "Antipyretic" ;
rdfs:comment "A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0000922 .
obo:SCDO_0001141 a rdfs:Class ;
rdfs:label "Test of Functional Health Literacy in Adults (TOFHLA)" ;
rdfs:comment "The Test of Functional Health Literacy Assessment (TOFHLA) assesses a patient's level of comprehension of health-related material. It is available in a full-format (a 22-minute test, with 50 reading comprehension items in three passages and 17 numeracy items), an abbreviated format (a 12-minute test, with 36 reading comprehension items in two passages and four numeracy items) and a shortened version (the S-TOFHLA, a 7-minute test, with 36 reading comprehension items in 2 passages.). The passages on the S-TOFHLA use a modified Cloze procedure where every fifth to seventh word is omitted and subjects select the correct word from among a set of four options. The passages contain information about an upper gastrointestinal tract x-ray procedure, and the \"Rights and Responsibilities\" section from a Medicaid application, and have Gunning-Fox readability indices of fourth and tenth grade, respectively. In early developmental studies, the reading comprehension passages in the S-TOFHLA had a reliability coefficient (Cronbach's alpha) of 0.97 and correlation with the Rapid Estimate of Adult Literacy in Medicine (REALM) of 0.81. Each selection is scored a \"1\" for correct or a \"0\" for incorrect and scores are summed over items to create a total score. The 36-point scale of the S-TOFHLA is divided into three categories of functional literacy: inadequate (0-16), adequate (17-22) and functional (23-36)." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:HP_0005268 a rdfs:Class ;
rdfs:label "Spontaneous Abortion" ;
rdfs:comment "A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 20th week of pregnancy." ;
rdfs:subClassOf obo:HP_0001787 , obo:NCIT_C34941 .
obo:SCDO_0000129 a rdfs:Class ;
rdfs:label "Birthplace of Parents" ;
rdfs:comment "The country or countires in which the respondent's biological parents were born." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:SCDO_0006905 a rdfs:Class ;
rdfs:label "Hypersplenism" ;
rdfs:comment "Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy." ;
rdfs:subClassOf obo:HP_0001743 .
obo:SCDO_0000776 a rdfs:Class ;
rdfs:label "Multidimensional Health Locus of Control Scales (MHLC)" ;
rdfs:comment "The multidimensional health locus of control (MHLC) scale is a widely used measure of the factors that people believe exert some measures of control over their health. The MHLC originally developed by Wallston and colleagues contained 3 subscales describing various types of control-related cognitions an individual may have about the current state of his or her health. These were: Internal Health Locus of Control (IHLC), Powerful Others Health Locus of Control (PHLC) and Chance Health Locus of Control (CHLC). Subsequently, a fourth subscale, the God Locus of Health Control (G LHC) scale was developed to assess the extent of an individual's belief that God controls his or her health status was added to the measure. Thus, the expanded MHLC Consists of 4 sub-scales: one Internal and 3 external subscales namely, powerful others, chance and God. Each of the 4 sub-scales has 6 items making a total of 24 items. The two original versions of the MHLC (forms A & B) deal with the general health status whereas the third version (Form C) assesses control-related cognitions about a specific disease state." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:SCDO_1000408 a rdfs:Class ;
rdfs:label "Data Use Requirements" ;
rdfs:comment "Requirements indicate additional conditions set for use of data." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:OBI_0001138 a rdfs:Class ;
rdfs:label "X-Ray Machine" ;
rdfs:comment "A device that is used to generate X-rays." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_1000081 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype C/S Antilles" ;
rdfs:comment "Compound heterozygosity for the hemoglobin C (HBB Glu6Lys) mutation and the double HBB Glu6Val, Val23Ile mutation of hemoglobin S-Antilles." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:NCIT_C95437 a rdfs:Class ;
rdfs:label "Acute Pancreatitis" ;
rdfs:comment "An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs." ;
rdfs:subClassOf obo:HP_0025031 , obo:SCDO_1000000 .
obo:SCDO_0000743 a rdfs:Class ;
rdfs:label "Membranous Nephropathy" ;
rdfs:comment "A type of glomerulonephropathy characterized by histology with thickening of the basement membrane and deposition of immune complexes in the subepithelial space." ;
rdfs:subClassOf obo:HP_0000112 , obo:HP_0002715 .
obo:SCDO_0000798 a rdfs:Class ;
rdfs:label "deprecated Nervous System" ;
rdfs:comment "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000593 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hydroxyurea Initiation Date Question" ;
rdfs:comment "The Sickle in Africa core data element that records the date on which the respondent started hydroxyurea therapy, in the format dd/mm/yyyy." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:OBI_0002557 a rdfs:Class ;
rdfs:label "Maximum Age Value Specification" ;
rdfs:comment "A value specifcation that specifies the oldest age when specifying an age range." ;
rdfs:subClassOf obo:SCDO_1000401 .
obo:SCDO_1000433 a rdfs:Class ;
rdfs:label "Intestinal Injury" ;
rdfs:comment "Damage inflicted on the intestine." ;
rdfs:subClassOf obo:HP_0025031 , obo:NCIT_C3671 .
obo:NCIT_C114714 a rdfs:Class ;
rdfs:label "Dialysis Membrane Reaction" ;
rdfs:comment "A severe hypersensitivity-like reaction occurring during dialysis due to exposure to the dialysis membrane." ;
rdfs:subClassOf obo:NCIT_C78254 .
obo:SCDO_1000340 a rdfs:Class ;
rdfs:label "History of Stroke" ;
rdfs:comment "A record of an individual's history of stroke(s) and associated symptoms such as slurred speech, double vision, loss of vision, and paralysis." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:SCDO_1000690 a rdfs:Class ;
rdfs:label "Hemoglobin A Level" ;
rdfs:comment "The amount of hemoglobin A present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:NCIT_C98805 a rdfs:Class ;
rdfs:label "Acquired Methemoglobinemia" ;
rdfs:comment "Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods." ;
rdfs:subClassOf obo:SCDO_0000753 .
obo:SCDO_1000493 a rdfs:Class ;
rdfs:label "Open-Ended Question" ;
rdfs:comment "A question that allows the respondent to give their own answer instead of selecting an answer from answer options." ;
rdfs:subClassOf obo:SCDO_1000475 .
obo:SCDO_0001083 a rdfs:Class ;
rdfs:label "Social Functioning" ;
rdfs:comment "Social functioning defines an individual's interactions with their environment and the ability to fulfill their role within such environments as work, social activities, and relationships with partners and family." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:SCDO_0001387 a rdfs:Class ;
rdfs:label "Homozygous Deletion of HBA1 and HBA2" ;
rdfs:comment "Deletion of all four alpha-globin genes resulting in the most severe form of alpha thalassemia, Hemoglobin Barts Hydrops Fetalis." ;
rdfs:subClassOf obo:SCDO_0001386 .
obo:SCDO_1000545 a rdfs:Class ;
rdfs:label "Calculated Current Age (Months)" ;
rdfs:comment "The current age of a patient, calculated using the current date and the patient's date of birth and provided in months." ;
rdfs:subClassOf obo:SCDO_1000527 .
obo:NCIT_C17357 a rdfs:Class ;
rdfs:label "Gender" ;
rdfs:comment "The assemblage of properties that distinguish people on the basis of the societal roles expected for the two sexes." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:SCDO_1000112 a rdfs:Class ;
rdfs:label "HBB, GLU22GLN" ;
rdfs:comment "A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine." ;
rdfs:subClassOf obo:SCDO_0002305 .
obo:SCDO_0000771 a rdfs:Class ;
rdfs:label "Morphine" ;
rdfs:comment "The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle." ;
rdfs:subClassOf obo:CHEBI_35482 .
obo:SCDO_0000263 a rdfs:Class ;
rdfs:label "Cohort Studies" ;
rdfs:comment "Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_0000922 a rdfs:Class ;
rdfs:label "Preventative Therapeutics" ;
rdfs:comment "Activities to prevent Sickle Cell Disease or its complications." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:SCDO_0000741 a rdfs:Class ;
rdfs:label "Meditation" ;
rdfs:comment "A state of consciousness in which the individual eliminates environmental stimuli from awareness so that the mind can focus on a single thing, producing a state of relaxation and relief from stress. A wide variety of techniques are used to clear the mind of stressful outside interferences. It includes meditation therapy. (Mosby's Medical, Nursing, and Allied Health Dictionary, 4th ed)" ;
rdfs:subClassOf obo:SCDO_0001284 .
obo:NCIT_C99042 a rdfs:Class ;
rdfs:label "Renal Vein Thrombosis" ;
rdfs:comment "The formation of a thrombus in the renal vein." ;
rdfs:subClassOf obo:HP_0000077 , obo:HP_0001977 .
obo:SCDO_1000329 a rdfs:Class ;
rdfs:label "Alcohol - Lifetime Use Diagnostic Instrument" ;
rdfs:comment "Question asking the respondent if s/he has ever consumed any alcoholic beverage during his or her entire life." ;
rdfs:subClassOf obo:SCDO_1000474 .
obo:SCDO_0000250 a rdfs:Class ;
rdfs:label "Clinical Neuropathy Assessment" ;
rdfs:comment "A physician administered examination to assess peripheral neuropathy." ;
rdfs:subClassOf obo:SCDO_0000898 .
obo:HP_0000999 a rdfs:Class ;
rdfs:label "Pyoderma" ;
rdfs:comment "Any manifestation of a skin disease associated with the production of pus." ;
rdfs:subClassOf obo:HP_0002715 , obo:HP_0011122 .
obo:SCDO_0001044 a rdfs:Class ;
rdfs:label "SF-36v2 Health Survey" ;
rdfs:comment "A 36-item instrument for measuring health status and outcomes via patient self-report. It is designed for use in surveys of general and specific populations, health policy evaluations, and clinical practice and research. The SF-36v2 measures the following eight health concepts, which are relevant across age, disease, and treatment groups: physical functioning, role limitations due to physical health problems, bodily pain, general health, vitality (energy/fatigue), social functioning, role limitations due to emotional problems, and mental health (psychological distress and psychological well-being). Both standard (4-week) and acute (1-week) recall versions are available. The survey's standardized scoring system yields a profile of eight health scores and two summary measures (physical and mental health) and a self-evaluated change in health status." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:SCDO_0009350 a rdfs:Class ;
rdfs:label "Splenic Sequestration" ;
rdfs:comment "An acute condition of intrasplenic pooling of large amounts of blood." ;
rdfs:subClassOf obo:HP_0001743 .
obo:HP_0000818 a rdfs:Class ;
rdfs:label "Abnormality of the Endocrine System" ;
rdfs:comment "An abnormality of the endocrine system." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0000506 a rdfs:Class ;
rdfs:label "Hematopoietic Stem Cell Transplantation" ;
rdfs:comment "Transfer of hematopoietic stem cells from bone marrow or blood between individuals within the same species (transplantation, homologous) or transfer within the same individual (transplantation, autologous). Hematopoietic stem cell transplantation has been used as an alternative to bone marrow transplantation in the treatment of a variety of neoplasms." ;
rdfs:subClassOf obo:SCDO_0000301 .
obo:SCDO_1000534 a rdfs:Class ;
rdfs:label "Blood Transfusion Since Last Visit" ;
rdfs:comment "An indication of whether the respondent has had a blood transfusion since their last hospital visit. This is any transfusion before enrolment if it is the patient's first hospital visit." ;
rdfs:subClassOf obo:SCDO_1000318 .
obo:HP_0000132 a rdfs:Class ;
rdfs:label "Menorrhagia" ;
rdfs:comment "Prolonged and/or excessive menses at regular intervals in excess of 80 ml or lasting longer than 7 days." ;
rdfs:subClassOf obo:HP_0012243 .
obo:SCDO_1000791 a rdfs:Class ;
rdfs:label "D57.43 Sickle-cell thalassemia beta zero with crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000323 .
obo:SCDO_0001099 a rdfs:Class ;
rdfs:label "Spirometer" ;
rdfs:comment "A spirometer is an apparatus for measuring the volume of air inspired and expired by the lungs. It is a precision differential pressure transducer for the measurements of respiration flow rates. The spirometer records the amount of air and the rate of air that is breathed in and out over a specified period of time." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_1000313 a rdfs:Class ;
rdfs:label "Diagnostic Device Visual Output" ;
rdfs:comment "The visual output that a specific diagnostic device produces." ;
rdfs:subClassOf obo:SCDO_0000379 .
obo:SCDO_0001167 a rdfs:Class ;
rdfs:label "Transcutaneous Electrical Nerve Stimulation" ;
rdfs:comment "The use of specifically placed small electrodes to deliver electrical impulses across the skin to relieve pain. It is used less frequently to produce anesthesia." ;
rdfs:subClassOf obo:SCDO_0000049 .
obo:NCIT_C78254 a rdfs:Class ;
rdfs:label "Device Complication" ;
rdfs:comment "Any problem arising from the use of a medical device." ;
rdfs:subClassOf obo:NCIT_C2959 .
obo:SCDO_0009169 a rdfs:Class ;
rdfs:label "obsolete Sickle Plus Structural Variant" ;
rdfs:comment "A hemoglobinopathy caused by compound heterozygous inheritance of one hemoglobin S allele and one hemoglobin allele that produces structurally abnormal hemoglobin." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0005339 a rdfs:Class ;
rdfs:label "Globin Phenotype" ;
rdfs:comment "The physical characteristics of the globin polypeptides that form hemoglobins." ;
rdfs:subClassOf obo:SCDO_0009613 .
obo:SCDO_0000651 a rdfs:Class ;
rdfs:label "Interrupted Time Series Analysis" ;
rdfs:comment "A study that uses observations at multiple time points before and after an intervention (the interruption), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_1000303 a rdfs:Class ;
rdfs:label "Hepatitis B Core IgG Antibody Test" ;
rdfs:comment "The determination of the amount of hepatitis B virus core IgG antibody in a biological specimen." ;
rdfs:subClassOf obo:SCDO_1000300 .
obo:HP_0002157 a rdfs:Class ;
rdfs:label "Azotaemia" ;
rdfs:comment "An increased concentration of nitrogen compounds in the blood." ;
rdfs:subClassOf obo:HP_0004364 .
obo:SCDO_0000317 a rdfs:Class ;
rdfs:label "D57.20 Sickle-cell/Hb-C disease without crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000316 .
obo:SCDO_0000763 a rdfs:Class ;
rdfs:label "Mobility Limitation" ;
rdfs:comment "Difficulty moving from place to place or from one position to another without assistance." ;
rdfs:subClassOf obo:SCDO_0000900 .
obo:SCDO_0000397 a rdfs:Class ;
rdfs:label "Drug Clearance Decreased AE" ;
rdfs:comment "An adverse event that has an outcome of a decreased amount of the drug excreted by the body." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:SCDO_0000424 a rdfs:Class ;
rdfs:label "Electrophoresis" ;
rdfs:comment "An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current." ;
rdfs:subClassOf obo:SCDO_0000216 .
obo:SCDO_0000948 a rdfs:Class ;
rdfs:label "Quality of Health Care" ;
rdfs:comment "The levels of excellence which characterize the health service or health care provided based on accepted standards of quality." ;
rdfs:subClassOf obo:SCDO_0000950 .
obo:SCDO_0000382 a rdfs:Class ;
rdfs:label "Diet, Food, and Nutrition" ;
rdfs:comment "Concepts involved with nutritional physiology, including categories of substances eaten for sustenance, nutritional phenomena and processes, eating patterns and habits, and measurable nutritional parameters." ;
rdfs:subClassOf obo:SCDO_0000487 .
obo:ARO_0000064 a rdfs:Class ;
rdfs:label "Amoxycillin" ;
rdfs:comment "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan." ;
rdfs:subClassOf obo:ARO_0000054 .
obo:UO_0000025 a rdfs:Class ;
rdfs:label "pg" ;
rdfs:comment "A mass unit which is equal to 10^[-12] g." ;
rdfs:subClassOf obo:UO_0000002 .
obo:SCDO_1000615 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Platelet Count Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the platelet count in the respondent's blood, as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000435 a rdfs:Class ;
rdfs:label "Environmental Disease Modifier" ;
rdfs:comment "An environmental factor that modifies one or more aspects of sickle cell disease (SCD) (such as temporal pattern, age of onset and mortality) for specific phenotype(s) in the Phenotype class." ;
rdfs:subClassOf obo:SCDO_0000391 .
obo:SCDO_0000710 a rdfs:Class ;
rdfs:label "Manometer" ;
rdfs:comment "An instrument that is used for measuring the pressure of liquids and gases." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_0000113 a rdfs:Class ;
rdfs:label "Beta Thalassemia Major" ;
rdfs:comment "A severe early-onset form of beta thalassemia characterized by severe anemia requiring regular red blood cell transfusions." ;
rdfs:subClassOf obo:SCDO_0000251 .
obo:SCDO_0002240 a rdfs:Class ;
rdfs:label "Disease Severity" ;
rdfs:comment "The presence and extensiveness of a disease in the body. It is objectively evaluated through diagnostic testing and physiological examination of the impaired biological organs or tissues, in cases in which disease severity can be distinguished from other realms of health, as in heart disease." ;
rdfs:subClassOf obo:NCIT_C43646 .
obo:SCDO_1000035 a rdfs:Class ;
rdfs:label "from therapeutics" ;
rdfs:comment "Terms deprecated in the \"Therapeutics\" class." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000573 a rdfs:Class ;
rdfs:label "Hospitalization" ;
rdfs:comment "The confinement of a patient in a hospital." ;
rdfs:subClassOf obo:SCDO_0000493 .
obo:SCDO_0008937 a rdfs:Class ;
rdfs:label "Central Retinal Artery Occlusion" ;
rdfs:comment "Blockage of blood flow in the central retinal artery. Results in sudden painless loss of vision and occurs in children and young adults. Thrombus formation in the retinal artery occurs spontaneously or in association with hyphema, Moyamoya and acute chest sydrome. There is no associated pain and it may be unilateral or bilateral." ;
rdfs:subClassOf obo:HP_0030680 .
obo:MP_0005534 a rdfs:Class ;
rdfs:label "Decreased Body Temperature" ;
rdfs:comment "Less than the level of heat natural to a living being." ;
rdfs:subClassOf obo:MP_0005535 .
obo:SCDO_1000299 a rdfs:Class ;
rdfs:label "Hepatitis B Surface Antibody Test" ;
rdfs:comment "The determination of the surface antibody reaction of a sample to the Hepatitis B virus." ;
rdfs:subClassOf obo:SCDO_1000302 .
obo:HP_0011907 a rdfs:Class ;
rdfs:label "Reduced Alpha/Beta Synthesis Ratio" ;
rdfs:comment "A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia." ;
rdfs:subClassOf obo:HP_0005560 .
obo:CHEBI_6807 a rdfs:Class ;
rdfs:label "Methadone" ;
rdfs:comment "A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence." ;
rdfs:subClassOf obo:CHEBI_35482 .
obo:SCDO_0007565 a rdfs:Class ;
rdfs:label "deprecated Major Area" ;
rdfs:comment "Distinct geographical area." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000483 a rdfs:Class ;
rdfs:label "deprecated Dropdown Multiple Choice Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:HP_0011695 a rdfs:Class ;
rdfs:label "Cerebellar Hemorrhage" ;
rdfs:comment "Hemorrhage into the parenchyma of the cerebellum." ;
rdfs:subClassOf obo:HP_0002170 .
obo:HP_0004727 a rdfs:Class ;
rdfs:label "Impaired Renal Concentrating Ability" ;
rdfs:comment "A defect in the ability to concentrate the urine." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_1000835 a rdfs:Class ;
rdfs:label "Normal Total Serum Bilirubin" ;
rdfs:comment "When the total bilirubin level in the serum is in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:NCIT_C16632 a rdfs:Class ;
rdfs:label "Geographic Area" ;
rdfs:comment "Any demarcated area of the Earth; may be determined by both natural and human boundaries." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_1000829 a rdfs:Class ;
rdfs:label "Normal Serum Creatinine" ;
rdfs:comment "When the level of serum creatinine is in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:SCDO_1000075 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype A/S-Oman" ;
rdfs:comment "Dominant heterozygosity for the double HBB Glu6Val and Glu121Lys mutation." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:SCDO_1000104 a rdfs:Class ;
rdfs:label "Hemoglobin Subunits" ;
rdfs:comment "The protein subunits that comprise multimeric hemoglobins." ;
rdfs:subClassOf obo:NCIT_C26548 .
obo:SCDO_1000875 a rdfs:Class ;
rdfs:label "Next of Kin Name" ;
rdfs:comment "The name of a respondent's next of kin." ;
rdfs:subClassOf obo:NCIT_C25191 .
obo:CMO_0000027 a rdfs:Class ;
rdfs:label "White Blood Cell Count" ;
rdfs:comment "The number of white blood cells in a specified volume of blood." ;
rdfs:subClassOf obo:CMO_0002341 .
obo:HP_0012100 a rdfs:Class ;
rdfs:label "Abnormal Circulating Creatinine Level" ;
rdfs:comment "An abnormal concentration of creatinine in the blood." ;
rdfs:subClassOf obo:HP_0004364 .
obo:SCDO_0001206 a rdfs:Class ;
rdfs:label "Urinary Creatinine Test" ;
rdfs:comment "A bioassay to measure urine concentration of creatinine, a muscle metabolite that is filtered out of blood by the kidneys." ;
rdfs:subClassOf obo:NCIT_C17241 , obo:SCDO_0000676 .
obo:SCDO_0001436 a rdfs:Class ;
rdfs:label "Oxygen Therapy" ;
rdfs:comment "The administration of oxygen to an individual. It is of paramount importance in the peri-operative care of SCD patients as hypoxaemia predisposes to sickling." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:NCIT_C128326 a rdfs:Class ;
rdfs:label "Intra-Abdominal Abscess" ;
rdfs:comment "An abscess within the abdomen." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:NCIT_C42559 a rdfs:Class ;
rdfs:label "Degree Celsius" ;
rdfs:comment "A unit of temperature of the temperature scale designed so that the freezing point of water is 0 degrees and the boiling point is 100 degrees at standard atmospheric pressure. The current official definition of the Celsius sets 0.01 C to be at the triple point of water and a degree to be 1/273.16 of the difference in temperature between the triple point of water and absolute zero. One degree Celsius represents the same temperature difference as one Kelvin." ;
rdfs:subClassOf obo:UO_0000005 .
obo:SCDO_0000986 a rdfs:Class ;
rdfs:label "Renal Tubular Acidosis" ;
rdfs:comment "Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_0001765 a rdfs:Class ;
rdfs:label "Beta-Minus Thalassemia Mutation" ;
rdfs:comment "A mutation in the beta-globin gene, HBB, that results in reduced beta globin synthesis." ;
rdfs:subClassOf obo:SCDO_0009731 .
obo:SCDO_1000484 a rdfs:Class ;
rdfs:label "deprecated Dropdown Single Choice Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:SCDO_0000565 a rdfs:Class ;
rdfs:label "Historically Controlled Study" ;
rdfs:comment "A study that compares a group of participants receiving an intervention with a similar group from the past who did not." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_1000869 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Religion Question" ;
rdfs:comment "The Sickle in Africa core data element that records the religion of a respondent." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0001920 a rdfs:Class ;
rdfs:label "Renal Artery Stenosis" ;
rdfs:comment "The presence of stenosis of the renal artery." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_0000558 a rdfs:Class ;
rdfs:label "obsolete Hepatitis C Test" ;
rdfs:comment "A test for Hepatitis C Virus." ;
rdfs:subClassOf obo:SCDO_1000034 .
obo:SCDO_1000149 a rdfs:Class ;
rdfs:label "Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit" ;
rdfs:comment "The second edition of the Clinical Care Guidelines of the Sickle Cell Unit, containing revised and expanded guidelines for the management of sickle cell disease. It outlines a standard of care that is informed by best practice, taking into account resource limitations locally and regionally. It also contains patient information leaflets." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_0000588 a rdfs:Class ;
rdfs:label "Hyperkalemia" ;
rdfs:comment "Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_1000757 a rdfs:Class ;
rdfs:label "Rectal Temperature" ;
rdfs:comment "The temperature of the lumen of the rectum." ;
rdfs:subClassOf obo:CMO_0000015 .
obo:HP_0007018 a rdfs:Class ;
rdfs:label "Attention Deficit Hyperactivity Disorder" ;
rdfs:comment "Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient." ;
rdfs:subClassOf obo:HP_0000708 .
obo:SCDO_0000306 a rdfs:Class ;
rdfs:label "Current Employment Status" ;
rdfs:comment "The respondent's current employment status." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0001090 , obo:SCDO_1000157 .
obo:SCDO_1000589 a rdfs:Class ;
rdfs:label "Blood Type AB Negative" ;
rdfs:comment "A blood type containing both type A and B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor" ;
rdfs:subClassOf obo:HP_0032224 .
obo:SCDO_0000028 a rdfs:Class ;
rdfs:label "Adverse Drug Event" ;
rdfs:comment "An adverse event that occurs after a drug administration." ;
rdfs:subClassOf obo:SCDO_1000093 .
obo:SCDO_1000037 a rdfs:Class ;
rdfs:label "Abnormality of the Cerebral Vasculature" ;
rdfs:comment "An abnormality of the cerebral vasculature." ;
rdfs:subClassOf obo:HP_0002597 .
obo:SCDO_1000798 a rdfs:Class ;
rdfs:label "D57.45 Sickle-cell thalassemia beta plus with crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000323 .
obo:DUO_0000021 a rdfs:Class ;
rdfs:label "Ethics Approval Required" ;
rdfs:comment "This requirement indicates that the requestor must provide documentation of local IRB/ERB approval." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:NCIT_C79903 a rdfs:Class ;
rdfs:label "Blood Smear" ;
rdfs:comment "A sample of blood applied in a thin film to a microscope slide for study under a microscope." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_0000576 a rdfs:Class ;
rdfs:label "Hydration Therapy" ;
rdfs:comment "A unique treatment that administers electrolyte-packed IV fluids directly into a patient's bloodstream. Depending on the patient's needs, the fluid may be enhanced with additives such as calcium, magnesium sulfate or a Vitamin B complex. It is a far more efficient method of absorption when compared to the traditional method of drinking liquids/electrolytes." ;
rdfs:subClassOf obo:NCIT_C15900 , obo:SCDO_0000922 .
obo:SCDO_0000551 a rdfs:Class ;
rdfs:label "Thalassemia Trait" ;
rdfs:comment "The inheritance of one of the faulty genes that causes thalassemia." ;
rdfs:subClassOf obo:NCIT_C95534 .
obo:CHMO_0001009 a rdfs:Class ;
rdfs:label "High-Performance Liquid Chromatography" ;
rdfs:comment "Column chromatography where the mobile phase is a liquid, the stationary phase consists of very small particles and the inlet pressure is relatively high." ;
rdfs:subClassOf obo:SCDO_0000216 , obo:SCDO_1000577 .
obo:NCIT_C35069 a rdfs:Class ;
rdfs:label "Thalassemia" ;
rdfs:comment "An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation." ;
rdfs:subClassOf obo:SCDO_0007192 .
obo:CMO_0000204 a rdfs:Class ;
rdfs:label "Blood Coagulation Measurement" ;
rdfs:comment "Measurement to assess the sequential process through which multiple factors of the blood interact to form an insoluble fibrin clot." ;
rdfs:subClassOf obo:CMO_0000035 .
obo:MP_0010067 a rdfs:Class ;
rdfs:label "Increased Red Blood Cell Distribution Width" ;
rdfs:comment "Higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism." ;
rdfs:subClassOf obo:MP_0010066 .
obo:HP_0100749 a rdfs:Class ;
rdfs:label "Chest Pain" ;
rdfs:comment "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest." ;
rdfs:subClassOf obo:SCDO_0000851 .
obo:ExO_0000048 a rdfs:Class ;
rdfs:label "Built Environment" ;
rdfs:comment "Human-made surroundings that provide the setting for human activity, ranging in scale from personal shelter and buildings to neighborhoods and cite, and can often include their supporting infrastructure, such as water supply or energy networks." ;
rdfs:subClassOf obo:SCDO_0000897 .
obo:SCDO_1000717 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Partial Pressure CO2 Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's partial pressure of carbon dioxide in their arterial blood, as measured by an arterial blood gas test." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001052 a rdfs:Class ;
rdfs:label "Sickle Cell Pain Management" ;
rdfs:comment "A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing sickle cell related pain." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:HP_0001889 a rdfs:Class ;
rdfs:label "Megaloblastic Anemia" ;
rdfs:comment "Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts)." ;
rdfs:subClassOf obo:HP_0001903 .
obo:SCDO_1000463 a rdfs:Class ;
rdfs:label "Approval of Ethics" ;
rdfs:comment "When a research ethics committee approves a study's application for approval of their proposed research." ;
rdfs:subClassOf obo:SCDO_1000462 .
obo:UO_0000005 a rdfs:Class ;
rdfs:label "Temperature Unit" ;
rdfs:comment "A unit which is a standard measure of the average kinetic energy of the particles in a sample of matter." ;
rdfs:subClassOf obo:UO_0000000 .
obo:SCDO_1000537 a rdfs:Class ;
rdfs:label "Temporal Observable" ;
rdfs:comment "Time-related information that can be observed." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_0000685 a rdfs:Class ;
rdfs:label "Leg Ulcer" ;
rdfs:comment "Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (varicose ulcer), 5% to arterial disease, and the remaining 5% to other causes." ;
rdfs:subClassOf obo:HP_0200042 .
obo:SCDO_0004847 a rdfs:Class ;
rdfs:label "Acute Hepatic Sequestration" ;
rdfs:comment "A rarely recognized complication of vaso-occlusive crisis. It is characterized by a presentation of right upper quadrant pain in the liver. A smooth, tender, enlarged liver is noted on physical exam. The lab values show a decrease in the hemoglobin/hematocrit. An increase in reticulocyte count is also seen." ;
rdfs:subClassOf obo:HP_0001392 , obo:NCIT_C115224 .
obo:SCDO_1000637 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Red Cell Distribution Width Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's red cell distribution width, as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001049 a rdfs:Class ;
rdfs:label "Sickle Cell Disease Screening Test" ;
rdfs:comment "Sickle cell tests are used to help diagnose sickle cell anemia (also called sickle cell disease) and to identify those who may have sickle cell trait. Sickle cell anemia is an inherited disorder that leads to the production of an abnormal hemoglobin called hemoglobin S (Hb S or Hgb S). Sickle cell tests determine the presence and relative amount of hemoglobin S in a blood sample." ;
rdfs:subClassOf obo:SCDO_0000781 .
obo:SCDO_0000747 a rdfs:Class ;
rdfs:label "Meta-Analysis" ;
rdfs:comment "Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_1000477 a rdfs:Class ;
rdfs:label "deprecated Field Type" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0000726 a rdfs:Class ;
rdfs:label "Dementia" ;
rdfs:comment "A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_1000837 a rdfs:Class ;
rdfs:label "Normal Urine Creatinine Level" ;
rdfs:comment "When the concentration of urine creatinine falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:HP_0009830 a rdfs:Class ;
rdfs:label "Peripheral Neuropathy" ;
rdfs:comment "Peripheral neuropathy is a general term for any disorder of the peripheral nervous system." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_1000058 a rdfs:Class ;
rdfs:label "Hemoglobin C-Harlem" ;
rdfs:comment "An abnormal hemoglobin in which two mutations occur in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the aspartic acid in position 73 is replaced by asparagine." ;
rdfs:subClassOf obo:SCDO_1000082 .
obo:SCDO_0000994 a rdfs:Class ;
rdfs:label "deprecated Respiratory System" ;
rdfs:comment "Lungs and respiratory system of the body." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0008623 a rdfs:Class ;
rdfs:label "Vaso-Occlusion" ;
rdfs:comment "The obstruction of blood vessels by altered erythrocytes that can result in pain, anemia and tissue ischemia." ;
rdfs:subClassOf obo:HP_0030680 .
obo:SCDO_0000072 a rdfs:Class ;
rdfs:label "Arteriovenous Malformation" ;
rdfs:comment "Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas." ;
rdfs:subClassOf obo:HP_0030680 .
obo:NCIT_C67376 a rdfs:Class ;
rdfs:label "IU/L" ;
rdfs:comment "Unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of one international unit per one liter of the system volume." ;
rdfs:subClassOf obo:UO_0000051 .
obo:MP_0005562 a rdfs:Class ;
rdfs:label "Decreased Mean Corpuscular Hemoglobin" ;
rdfs:comment "Less than the average levels of hemoglobin contained in an erythrocyte." ;
rdfs:subClassOf obo:MP_0001589 .
obo:SCDO_0005279 a rdfs:Class ;
rdfs:label "deprecated High Reticulocyte Count" ;
rdfs:comment "An abnormally high number of reticulocytes per unit volume of blood. The normal fraction of reticulocytes in the blood depends on the clinical situation but is usually 0.5% to 2.5% in adults and 2% to 6% in infants." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0001433 a rdfs:Class ;
rdfs:label "Hepatosplenomegaly" ;
rdfs:comment "Simultaneous enlargement of the liver and spleen." ;
rdfs:subClassOf obo:HP_0001392 , obo:HP_0001743 , obo:NCIT_C115224 .
obo:UO_0000000 a rdfs:Class ;
rdfs:label "Unit of Measurement" ;
rdfs:comment "A standardized quantity of a physical quality." ;
rdfs:subClassOf obo:SCDO_1000472 .
obo:HP_0003265 a rdfs:Class ;
rdfs:label "Neonatal Hyperbilirubinemia" ;
rdfs:comment "A type of hyperbilirubinemia with neonatal onset." ;
rdfs:subClassOf obo:NCIT_C27088 .
obo:NCIT_C155310 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-SD" ;
rdfs:comment "A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin D mutations. Patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin SS disease." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000163 .
obo:SCDO_0001751 a rdfs:Class ;
rdfs:label "Homozygous Deletion of HBA2" ;
rdfs:comment "Deletion of both HBA2 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia." ;
rdfs:subClassOf obo:SCDO_0001386 .
obo:SCDO_1000701 a rdfs:Class ;
rdfs:label "Hemoglobin D-Punjab Level" ;
rdfs:comment "The amount of hemoglobin D-Punjab present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:NCIT_C68615 a rdfs:Class ;
rdfs:label "Birth Date" ;
rdfs:comment "The calendar date on which a person was born." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_1000537 .
obo:SCDO_0000102 a rdfs:Class ;
rdfs:label "Beck Anxiety Inventory (BAI)" ;
rdfs:comment "The BAI is the most widely used instument for measuring anxiety. It consists of 21 items to assess how bothersome a symptom of anxiety has been for the subject over the past month. Scoring the BAI is based on a 0-3 point scale with higher scores indicating severity." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:SCDO_1000657 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Alanine Aminotransferase Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the level of alanine aminotransferase in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:DOID_813 a rdfs:Class ;
rdfs:label "Septic Arthritis" ;
rdfs:comment "An arthritis that involves infection by a pathogen located in a joint." ;
rdfs:subClassOf obo:HP_0000924 , obo:IDO_0000586 .
obo:SCDO_0001626 a rdfs:Class ;
rdfs:label "Nonsense Codon" ;
rdfs:comment "An amino acid-specifying codon that has been converted to a stop codon by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon." ;
rdfs:subClassOf obo:SCDO_0004623 .
obo:HP_0001878 a rdfs:Class ;
rdfs:label "Hemolytic Anemia" ;
rdfs:comment "A type of anemia caused by premature destruction of red blood cells (hemolysis)." ;
rdfs:subClassOf obo:HP_0001903 .
obo:SCDO_1000357 a rdfs:Class ;
rdfs:label "Self Reported Educational Attainment" ;
rdfs:comment "A measure of educational progress reported using a questionnaire based approach, often used as a proxy for cognitive performance as the two are correlated." ;
rdfs:subClassOf obo:SCDO_0000305 .
obo:SCDO_1000430 a rdfs:Class ;
rdfs:label "Ethics Related Concept" ;
rdfs:comment "Concepts related to ethics, excluding types of ethics." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:CHEBI_60809 a rdfs:Class ;
rdfs:label "Adjuvant" ;
rdfs:comment "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:SCDO_1000238 a rdfs:Class ;
rdfs:label "CYB5R3 Mutation" ;
rdfs:comment "A mutation in the NADH-Cytochrome b5 Reductase 3 gene, CYB5R3, that contributes to the presence of methemoglobinemia (type I or II)." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_1000578 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - SCD Test Other Result Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's SCD test result, in the case where the specific result was not listed as an answer option in a previous data element." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000597 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Folic Acid Use Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's folic acid use status (i.e. an indication of whether the respondent is using folic acid)." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0002808 a rdfs:Class ;
rdfs:label "Kyphosis" ;
rdfs:comment "Exaggerated anterior convexity of the thoracic vertebral column." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_0000386 a rdfs:Class ;
rdfs:label "Disability-Adjusted Life Year (DALY)" ;
rdfs:comment "One DALY can be thought of as one lost year of \"healthy\" life. The sum of these DALYs across the population, or the burden of disease, can be thought of as a measurement of the gap between current health status and an ideal health situation where the entire population lives to an advanced age, free of disease and disability." ;
rdfs:subClassOf obo:SCDO_0000495 , obo:SCDO_0000951 .
obo:NCIT_C102531 a rdfs:Class ;
rdfs:label "Pulmonary Infiltrate" ;
rdfs:comment "A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma." ;
rdfs:subClassOf obo:HP_0002086 .
obo:SCDO_1000686 a rdfs:Class ;
rdfs:label "Reticulocyte Count Assay" ;
rdfs:comment "A test used to measure the reticulocyte count (number of reticulocytes in a given volume of blood)." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:HP_0001382 a rdfs:Class ;
rdfs:label "Joint Hypermobility" ;
rdfs:comment "The ability of a joint to move beyond its normal range of motion." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_1000645 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Serum Creatinine Concentration Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the level of serum creatinine in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:HP_0031964 a rdfs:Class ;
rdfs:label "Elevated Serum Alanine Aminotransferase" ;
rdfs:comment "An abnormally high concentration in the circulation of alanine aminotransferase (ALT), which is an enzyme that catalyzes the transfer of amino groups to form the hepatic metabolite oxaloacetate. ALT is found abundantly in the cytosol of the hepatocyte. ALT activity in the liver is about 3000 times that of serum activity. Thus, in the case of hepatocellular injury or death, release of ALT from damaged liver cells increases measured ALT activity in the serum. Although it is generally thought to be specific to the liver, it is also found in the kidney, and, in much smaller quantities, in heart and skeletal muscle cells." ;
rdfs:subClassOf obo:HP_0012379 .
obo:SCDO_1000787 a rdfs:Class ;
rdfs:label "D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000318 .
obo:SCDO_0000094 a rdfs:Class ;
rdfs:label "BCL11A" ;
rdfs:comment "This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene." ;
rdfs:subClassOf obo:SCDO_0000810 .
obo:NCIT_C16567 a rdfs:Class ;
rdfs:label "Exercise" ;
rdfs:comment "Activity that requires physical or mental exertion, especially when performed to develop or maintain fitness." ;
rdfs:subClassOf obo:NCIT_C15900 , obo:SCDO_0000487 .
obo:SCDO_0000833 a rdfs:Class ;
rdfs:label "Ophthalmologic Surgical Procedure" ;
rdfs:comment "Surgery performed on the eye or any of its parts." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:SCDO_1000474 a rdfs:Class ;
rdfs:label "Clinical or Research Assessment Data Element" ;
rdfs:comment "A data element used to capture or facilitate the capture of data in a clinical or research assessment." ;
rdfs:subClassOf obo:SCDO_1000472 .
obo:SCDO_1000295 a rdfs:Class ;
rdfs:label "Quality of Life Assessment Score" ;
rdfs:comment "The score obtained from a quality of life-related diagnostic instrument." ;
rdfs:subClassOf obo:SCDO_1000318 .
obo:NCIT_C35372 a rdfs:Class ;
rdfs:label "Ascending Cholangitis" ;
rdfs:comment "Acute infection of the bile ducts caused by bacteria ascending from the small intestine." ;
rdfs:subClassOf obo:HP_0025031 .
obo:SCDO_1000115 a rdfs:Class ;
rdfs:label "HBB, GLU121ALA" ;
rdfs:comment "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by alanine." ;
rdfs:subClassOf obo:SCDO_0002305 .
obo:SCDO_0000774 a rdfs:Class ;
rdfs:label "obsolete Multicenter Study" ;
rdfs:comment "'A work that reports on a study executed by several cooperating institutions. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000941 .
obo:SCDO_1000808 a rdfs:Class ;
rdfs:label "Decreased Arterial Oxygen Saturation" ;
rdfs:comment "An abnormal reduction in the amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity." ;
rdfs:subClassOf obo:MP_0002329 .
obo:SCDO_0000940 a rdfs:Class ;
rdfs:label "Psychotherapy" ;
rdfs:comment "A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication." ;
rdfs:subClassOf obo:SCDO_0001129 .
obo:SCDO_0005167 a rdfs:Class ;
rdfs:label "Chronic Anemia" ;
rdfs:comment "Long lasting form of anemia." ;
rdfs:subClassOf obo:HP_0001903 , obo:SCDO_0001334 .
obo:SCDO_0008713 a rdfs:Class ;
rdfs:label "Sickle Cell Anemia Associated with Alpha Thalassemia" ;
rdfs:comment "The concurrence of sickle cell anemia and alpha-thalassemia. This condition is thought to result in less severe hemolytic anemia due to reduced concentration of hemoglobin S and its polymerization within red blood cells." ;
rdfs:subClassOf obo:SCDO_1000106 .
obo:SCDO_1000371 a rdfs:Class ;
rdfs:label "Prenatal Maternal Abnormality" ;
rdfs:comment "A health abnormality in a woman during pregnancy." ;
rdfs:subClassOf obo:HP_0001197 .
obo:SCDO_0000405 a rdfs:Class ;
rdfs:label "deprecated Ear, Nose and Throat" ;
rdfs:comment "'The combined specialties of diseases of the ear, pharynx, and larynx, including the upper respiratory tract and diseases of the head and neck, tracheobronchial tree, and esophagus. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000679 a rdfs:Class ;
rdfs:label "Past Partner Status" ;
rdfs:comment "An indication of whether a person has previously lived with someone as though married (in a romantic relationship and lived together but were not married)." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:HP_0000969 a rdfs:Class ;
rdfs:label "Edema" ;
rdfs:comment "An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_1000466 a rdfs:Class ;
rdfs:label "Written Consent" ;
rdfs:comment "When the participant or a legal representative or family member provides consent by filling out and/or signing a written form." ;
rdfs:subClassOf obo:SCDO_1000465 .
obo:NCIT_C126120 a rdfs:Class ;
rdfs:label "Oxygenated Hemoglobin" ;
rdfs:comment "Hemoglobin where the heme group has formed a reversible complex with oxygen (O2) in the lungs. This molecule is found in the systemic arteries and transports O2 from the lungs to the tissues where it is readily released." ;
rdfs:subClassOf obo:NCIT_C16676 .
obo:SCDO_0001234 a rdfs:Class ;
rdfs:label "Virus" ;
rdfs:comment "Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells." ;
rdfs:subClassOf obo:OBI_0000925 .
obo:SCDO_0000166 a rdfs:Class ;
rdfs:label "Bronchodilator Responsiveness Test" ;
rdfs:comment "A test to assess an individual's change in pulmonary function in response to inhaled bronchodilator medications." ;
rdfs:subClassOf obo:SCDO_0000942 .
obo:SCDO_1000252 a rdfs:Class ;
rdfs:label "Increased Red Cell Osmotic Resistance" ;
rdfs:subClassOf obo:HP_0020054 .
obo:SCDO_1000883 a rdfs:Class ;
rdfs:label "Telephone Number 2" ;
rdfs:comment "A respondent's secondary telephone number." ;
rdfs:subClassOf obo:NCIT_C40978 .
obo:HP_0001743 a rdfs:Class ;
rdfs:label "Abnormality of the Spleen" ;
rdfs:comment "An abnormality of the spleen." ;
rdfs:subClassOf obo:HP_0002715 , obo:HP_0025031 .
obo:SCDO_0300003 a rdfs:Class ;
rdfs:label "Publication Formats" ;
rdfs:comment "Specific genre of publication." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:SCDO_1000706 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin F Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin F." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000165 a rdfs:Class ;
rdfs:label "Sickle Cell Disease A/S-Oman" ;
rdfs:comment "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation (beta6 Glu > Val) and the hemoglobin O-Arab mutation (beta121 Glu > Lys). The other beta globin allele produces normal beta globin chains." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000211 .
obo:SCDO_0001369 a rdfs:Class ;
rdfs:label "Genetic Variation" ;
rdfs:comment "Deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents." ;
rdfs:subClassOf obo:SCDO_0000765 .
obo:SCDO_0000328 a rdfs:Class ;
rdfs:label "D57.419 Sickle-cell thalassemia, unspecified, with crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000325 .
obo:SCDO_0005446 a rdfs:Class ;
rdfs:label "Fetal Hemoglobin" ;
rdfs:comment "The major component of hemoglobin in the fetus. This hemoglobin has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by leukemia and several types of anemia." ;
rdfs:subClassOf obo:SCDO_0006835 .
obo:SCDO_0000900 a rdfs:Class ;
rdfs:label "Physical Functioning" ;
rdfs:comment "One's ability to carry out activities that require physical actions, ranging from self-care (activities of daily living) to more complex activities that require a combination of skills, often within a social context. Physical function is inclusive of the term disability and includes the full spectrum of physical functioning from severe impairment to exceptional physical abilities." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:NCIT_C19296 a rdfs:Class ;
rdfs:label "Deletion Mutation" ;
rdfs:comment "Any rearrangement to the genomic content that results in the loss of one or more nucleotides of DNA. Deletions are generally irreversible rearrangements. They may alter the reading frame of a gene, or may result in loss of large chromosomal regions." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_0000501 a rdfs:Class ;
rdfs:label "Heart Rate" ;
rdfs:comment "The number of times the heart ventricles contract per unit of time, usually per minute." ;
rdfs:subClassOf obo:SCDO_1000317 .
obo:HP_0004756 a rdfs:Class ;
rdfs:label "Ventricular Tachycardia" ;
rdfs:comment "A tachycardia originating in the ventricles characterized by rapid heart rate (over 100 beats per minute) and broad QRS complexes (over 120 ms)." ;
rdfs:subClassOf obo:SCDO_0001851 .
obo:HP_0001931 a rdfs:Class ;
rdfs:label "Hypochromic Anemia" ;
rdfs:comment "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes." ;
rdfs:subClassOf obo:HP_0001903 .
obo:SCDO_1000048 a rdfs:Class ;
rdfs:label "SCD Genotype" ;
rdfs:comment "The alleles, or variant forms of the HBB gene, that are carried by an SCD sufferer." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_1000510 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Urinary Albumin Concentration Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the concentration of albumin in the respondent's urine." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000008 a rdfs:Class ;
rdfs:label "Hemoglobin M" ;
rdfs:comment "A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha, beta or gamma chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis." ;
rdfs:subClassOf obo:SCDO_0003807 .
obo:HP_0003418 a rdfs:Class ;
rdfs:label "Back Pain" ;
rdfs:comment "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back." ;
rdfs:subClassOf obo:SCDO_0000851 .
obo:CMO_0000508 a rdfs:Class ;
rdfs:label "Hemoglobin Measurement" ;
rdfs:comment "A measure of the oxygen carrying pigment of erythrocytes." ;
rdfs:subClassOf obo:CMO_0000036 .
obo:SCDO_0000990 a rdfs:Class ;
rdfs:label "obsolete Research Activity" ;
rdfs:comment "'Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000031 .
obo:CMO_0000038 a rdfs:Class ;
rdfs:label "Mean Corpuscular Volume" ;
rdfs:comment "A measure of the average volume or size of a single red blood cell. It is derived by dividing the total volume of packed red blood cells by the total red blood cell count." ;
rdfs:subClassOf obo:CMO_0001356 .
obo:SCDO_1000818 a rdfs:Class ;
rdfs:label "Absent Hemoglobin O-Arab" ;
rdfs:comment "A lack of production of hemoglobin O-Arab." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:HP_0200042 a rdfs:Class ;
rdfs:label "Skin Ulcer" ;
rdfs:comment "A discontinuity of the skin exhibiting loss of the epidermis and often portions of the dermis and subcutaneous fat." ;
rdfs:subClassOf obo:HP_0011121 , obo:SCDO_0000954 .
obo:SCDO_0005580 a rdfs:Class ;
rdfs:label "deprecated-Avascular Necrosis of the Femoral Head" ;
rdfs:comment "Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterised by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty." ;
rdfs:subClassOf obo:NCIT_C118385 .
obo:SCDO_0004836 a rdfs:Class ;
rdfs:label "Angina" ;
rdfs:comment "A chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_0000531 a rdfs:Class ;
rdfs:label "Hemoglobin E Trait" ;
rdfs:comment "The inheritance of the gene for hemoglobin E from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ;
rdfs:subClassOf obo:NCIT_C95534 .
obo:HP_0011413 a rdfs:Class ;
rdfs:label "Shoulder Dystocia" ;
rdfs:comment "Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex." ;
rdfs:subClassOf obo:HP_0001787 .
obo:SCDO_0000120 a rdfs:Class ;
rdfs:label "Biochemical Assay" ;
rdfs:comment "An analytical in vitro procedure used to detect, quantify and/or study the binding or activity of a biological molecule, such as an enzyme." ;
rdfs:subClassOf obo:SCDO_0000216 .
obo:SCDO_0002243 a rdfs:Class ;
rdfs:label "Research Participant Compensation" ;
rdfs:comment "Reimbursement of research participants for costs directly incurred during the research, such as travel costs and reasonable compensation for their inconvenience and time spent. Compensation can be monetary or non-monetary." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_0000547 a rdfs:Class ;
rdfs:label "Hemoglobin Profile Assay" ;
rdfs:comment "A bioassay that measures and identifies the different types of hemoglobin in the bloodstream. It can be used to identify and characterize the different variants in structure and synthesis of hemoglobin that cause sickle cell disease." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:OPMI_0000024 a rdfs:Class ;
rdfs:label "No" ;
rdfs:comment "An answer to question where the answer is No." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_1000575 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Type of SCD Test Question" ;
rdfs:comment "The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:NCIT_C97123 a rdfs:Class ;
rdfs:label "Conjugate Pneumococcal Vaccine" ;
rdfs:comment "An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes individually conjugated to proteins." ;
rdfs:subClassOf obo:VO_0000675 .
obo:SCDO_1000132 a rdfs:Class ;
rdfs:label "Meru" ;
rdfs:comment "The Meru tribe or Merus is a Bantu ethnic group. They reside on Mount Kenya's agriculturally rich northeastern slopes, in Kenya's Eastern Province. The name Meru refers to both the people and the location. Merus are primarily agrarian, raising a few domestic animals." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000824 a rdfs:Class ;
rdfs:label "Normal Platelet Count" ;
rdfs:comment "When the number of platelets in a specified volume of blood falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:SCDO_1000455 a rdfs:Class ;
rdfs:label "Calculated Current Age (Years)" ;
rdfs:comment "The current age of a patient, calculated using the current date and the patient's date of birth and provided in years." ;
rdfs:subClassOf obo:SCDO_1000527 .
obo:SCDO_0003572 a rdfs:Class ;
rdfs:label "Consent Form" ;
rdfs:comment "Documents describing a medical treatment or research project, including proposed procedures, risks, and alternatives, that are to be signed by an individual, or the individual's proxy, to indicate his/her understanding of the document and a willingness to undergo the treatment or to participate in the research." ;
rdfs:subClassOf obo:SCDO_0007597 .
obo:SCDO_0000725 a rdfs:Class ;
rdfs:label "Measure of Frequency of Sickle Cell Pain Episodes" ;
rdfs:comment "A questionnaire to capture the frequency of acute pain episodes within a defined time frame due to sickle cell disease (SCD). It includes three self-administered questions from the Cooperative Study of Sickle Cell Disease (CSSCD) that capture number of painful episodes that required visits to the emergency room or hospital or interfered with daily activities." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_0000953 , obo:SCDO_1000033 .
obo:SCDO_0000926 a rdfs:Class ;
rdfs:label "Proliferative Sickle Retinopathy" ;
rdfs:comment "Sickle retinopathy that involves the upregulation of vascular growth factors due to chronic changes of local hypoxia and ischemia." ;
rdfs:subClassOf obo:SCDO_0001067 .
obo:NCIT_C91106 a rdfs:Class ;
rdfs:label "Clinical or Research Assessment Answer" ;
rdfs:comment "A statement (either spoken or written) that is made in reply to a clinical research assessment question." ;
rdfs:subClassOf obo:SCDO_1000472 .
obo:HP_0012282 a rdfs:Class ;
rdfs:label "Morbilliform Rash" ;
rdfs:comment "An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days." ;
rdfs:subClassOf obo:HP_0011122 .
obo:SCDO_1000611 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - White Blood Cell Count Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the white blood cell count in the respondent's blood, as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0002814 a rdfs:Class ;
rdfs:label "deprecated Globin Gene" ;
rdfs:comment "'The hemoglobin molecule that transports oxygen in the blood is made up of a number of components. Human hemoglobin is a tetramer: in adults it is made up of two alpha globins and two beta globins; in the fetus, of two alpha and two g globins; and in the embryo, two e and two z globins. The sequences of these five globin types are similar and the genes that code for them occur in clusters on the chromosomes. In humans, there are two main clusters of globin genes: the alpha globin cluster on chromosome 16 and the beta globin cluster on chromosome 11. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0001027 a rdfs:Class ;
rdfs:label "Secondary Healthcare" ;
rdfs:comment "Specialized healthcare delivered as a follow-up or referral from a primary care provider." ;
rdfs:subClassOf obo:SCDO_0000494 .
obo:HP_0001010 a rdfs:Class ;
rdfs:label "Hypopigmentation" ;
rdfs:comment "A reduction of skin color related to a decrease in melanin production and deposition." ;
rdfs:subClassOf obo:HP_0011121 .
obo:SCDO_1000815 a rdfs:Class ;
rdfs:label "Normal Methemoglobin Level" ;
rdfs:comment "When the level of methemoglobin detected in a sample of blood falls in the normal range for methemoglobin." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_1000314 a rdfs:Class ;
rdfs:label "Red Blood Cell Microparticles Assay" ;
rdfs:comment "A bioassay to measure levels of red blood cell microparticles." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_0001152 a rdfs:Class ;
rdfs:label "Therapeutics" ;
rdfs:comment "Procedures, agents or devices concerned with the remedial treatment or prevention of diseases." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_1000480 a rdfs:Class ;
rdfs:label "deprecated Checkbox Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:HP_0000084 a rdfs:Class ;
rdfs:label "Kidney Failure" ;
rdfs:comment "Failure of the kidneys to adequately filter toxins and waste products from the blood; classified as acute (as in acute kidney injury) or chronic (as in chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur." ;
rdfs:subClassOf obo:HP_0000077 , obo:SCDO_1000383 .
obo:SCDO_0008262 a rdfs:Class ;
rdfs:label "Structural Hemoglobinopathy" ;
rdfs:comment "A hemoglobinopathy caused by the presence of structurally abnormal hemoglobins." ;
rdfs:subClassOf obo:SCDO_0000552 .
obo:SCDO_0000677 a rdfs:Class ;
rdfs:label "Kinesiotherapy" ;
rdfs:comment "A specialized area of medicine in which exercise and movement are used as the primary form of rehabilitation." ;
rdfs:subClassOf obo:SCDO_0000978 .
obo:HP_0002204 a rdfs:Class ;
rdfs:label "Pulmonary Embolism" ;
rdfs:comment "An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery." ;
rdfs:subClassOf obo:HP_0030680 .
obo:SCDO_0001252 a rdfs:Class ;
rdfs:label "X-Ray Therapy" ;
rdfs:comment "Medical treatment involving the use of controlled amounts of X-Rays." ;
rdfs:subClassOf obo:SCDO_0001129 .
obo:HP_0004870 a rdfs:Class ;
rdfs:label "Chronic Hemolytic Anemia" ;
rdfs:comment "A chronic form of hemolytic anemia." ;
rdfs:subClassOf obo:HP_0001878 , obo:SCDO_0005167 .
obo:SCDO_1000522 a rdfs:Class ;
rdfs:label "Temporal Observable of Consent" ;
rdfs:comment "Time-related information that can be observed and is related to consent." ;
rdfs:subClassOf obo:SCDO_0007597 , obo:SCDO_1000537 .
obo:NCIT_C40978 a rdfs:Class ;
rdfs:label "Telephone Number" ;
rdfs:comment "A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_0001063 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S/Lepore Boston" ;
rdfs:comment "Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three Hb Lepore variants described in association with HbS." ;
rdfs:subClassOf obo:NCIT_C95539 .
obo:SCDO_0000852 a rdfs:Class ;
rdfs:label "Pain Status" ;
rdfs:comment "The impact of sickle cell pain on the daily activities of patients. The degree to which pain interferes with their quality of life. This pain is related to the unique features of Sickle Cell Disease." ;
rdfs:subClassOf obo:SCDO_0000900 .
obo:CHEBI_35475 a rdfs:Class ;
rdfs:label "Non-Steroidal Anti-Inflammatory Drug" ;
rdfs:comment "An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." ;
rdfs:subClassOf obo:SCDO_0000057 .
obo:SCDO_1000843 a rdfs:Class ;
rdfs:label "Hypercapnia" ;
rdfs:comment "A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood." ;
rdfs:subClassOf obo:MP_0002329 .
obo:SCDO_1000154 a rdfs:Class ;
rdfs:label "ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children" ;
rdfs:comment "A document that describes various ways in which sickle cell disease can be managed and its complications can be prevented in children." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_1000894 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Priapism Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether a participant has priapism." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001079 a rdfs:Class ;
rdfs:label "Smoking" ;
rdfs:comment "Inhaling and exhaling the smoke of burning tobacco (Cigar, Cigarette, Hookah, Pipe, Smoking, Waterpipe)." ;
rdfs:subClassOf obo:SCDO_0000487 .
obo:SCDO_1000125 a rdfs:Class ;
rdfs:label "Kikuyu" ;
rdfs:comment "The Kikuyu are the largest single ethnic tribe in Kenya, making up 22% of the country's population. It is believed that the Kikuyu people migrated from Lake Chad to East Africa in 1000 AD, settling in the fertile central highlands of Kenya and engaging in farming." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000069 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/HPFH" ;
rdfs:comment "Genotype whereby a person is heterozygous for a hemoglobin S mutation and heterozygous for a mutation that causes persistant fetal hemoglobin production into adulthood. HPFH causative mutations are largely due to deletions in the beta-globin locus, but also by point mutations in the gamma-globin gene promoters." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:SCDO_0000810 a rdfs:Class ;
rdfs:label "Non-Globin Gene" ;
rdfs:comment "A gene that does not encode a globin family protein." ;
rdfs:subClassOf obo:NCIT_C16612 .
obo:SCDO_0006517 a rdfs:Class ;
rdfs:label "Human Subject Research" ;
rdfs:comment "Research involving the collection, storage, or use of private data or biological samples from living individuals by means of interactions, interventions, surveys, or other research methods or procedures." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:NCIT_C52009 a rdfs:Class ;
rdfs:label "Amniocentesis" ;
rdfs:comment "A prenatal diagnostic procedure in which a small sample of amniotic fluid is removed from the uterus by a needle inserted into the abdomen. This procedure is used to detect various genetic abnormalities in the fetus and/or the sex of the fetus." ;
rdfs:subClassOf obo:SCDO_0000919 .
obo:SCDO_1000458 a rdfs:Class ;
rdfs:label "Prospective Consent" ;
rdfs:comment "Consent given prior to enrollment." ;
rdfs:subClassOf obo:SCDO_1000457 .
obo:HP_0012465 a rdfs:Class ;
rdfs:label "Elevated Hepatic Iron Concentration" ;
rdfs:comment "An increased level of iron in liver tissues." ;
rdfs:subClassOf obo:HP_0001392 , obo:NCIT_C115224 .
obo:SCDO_0001268 a rdfs:Class ;
rdfs:label "Functional Assessment of Chronic Illness Therapy-Spirituality (FACIT-Sp) Scale" ;
rdfs:comment "The FACIT-Sp is a 12-item measure that asks participants to indicate how true various statements are about them on a Likert scale of 0 (\"not at all\") to 4 (\"very much\"). Responses on the FACIT-Sp are summed to create a total score, ranging from 0 to 48, with higher scores representing higher levels of spirituality." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:HP_0000873 a rdfs:Class ;
rdfs:label "Diabetes Insipidus" ;
rdfs:comment "A state of excessive water excretion and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus)." ;
rdfs:subClassOf obo:HP_0000818 .
obo:SCDO_1000508 a rdfs:Class ;
rdfs:label "SickleInAfrica Data Element" ;
rdfs:comment "A data element in a SickleInAfrica data capture instrument." ;
rdfs:subClassOf obo:SCDO_1000474 .
obo:SCDO_1000093 a rdfs:Class ;
rdfs:label "Adverse Event (AE)" ;
rdfs:comment "A medically undesirable event occurring in a research subject, such as an abnormal sign, symptom, worsening of a disease, injury, etc. A serious adverse event (SAE) results in death, hospitalization (or increased hospital stay), persistent disability, birth defect, or any other outcome that seriously jeopardizes the subject's health." ;
rdfs:subClassOf obo:SCDO_0000391 .
obo:SCDO_1000694 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin C Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin C." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000173 a rdfs:Class ;
rdfs:label "Billable ICD-10-CM Code" ;
rdfs:comment "An ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes as there are no codes with a greater level of specificity under each code." ;
rdfs:subClassOf obo:SCDO_1000100 .
obo:SCDO_1000227 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype AE" ;
rdfs:comment "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin E. Individuals with this genotype are known to be carriers of the hemoglobin E trait." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:SCDO_0008888 a rdfs:Class ;
rdfs:label "Iron Chelation Therapy" ;
rdfs:comment "The removal of excess iron from the body with special drugs." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:SCDO_0000822 a rdfs:Class ;
rdfs:label "Occupational Therapy" ;
rdfs:comment "Skilled treatment that helps individuals achieve independence in all facets of their lives. It assists in the development of skills needed for independent living." ;
rdfs:subClassOf obo:SCDO_0000978 .
obo:NCIT_C2959 a rdfs:Class ;
rdfs:label "Complication" ;
rdfs:comment "Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_1000514 a rdfs:Class ;
rdfs:label "Study Enrollment Consent" ;
rdfs:comment "Voluntary authorization given by a respondent and/or their proxy to be enrolled into a study as a research subject." ;
rdfs:subClassOf obo:SCDO_0007087 .
obo:SCDO_0000278 a rdfs:Class ;
rdfs:label "obsolete Consensus Development Conference, NIH" ;
rdfs:comment "'Work consisting of summary statements, from a conference sponsored by NIH, representing the majority of current opinion of physicians, scientists, and other professionals on a selected subject. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000277 .
obo:HP_0030127 a rdfs:Class ;
rdfs:label "Endometriosis" ;
rdfs:comment "The growth of endometrial tissue outside the uterus." ;
rdfs:subClassOf obo:HP_0012243 .
obo:HP_0011121 a rdfs:Class ;
rdfs:label "Abnormality of Skin Morphology" ;
rdfs:comment "Any morphological abnormality of the skin." ;
rdfs:subClassOf obo:HP_0000951 .
obo:IDOMAL_50000026 a rdfs:Class ;
rdfs:label "Mutation" ;
rdfs:comment "A permanent change in the DNA sequence of a gene that alters the genetic message carried by that gene." ;
rdfs:subClassOf obo:SCDO_0001369 .
obo:SCDO_1000542 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Site Participant Number Question" ;
rdfs:comment "The Sickle in Africa core data element that records the site-specific unique identifier that was assigned to the study participant by the data collectors at the data collection site." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:OGMS_0000047 a rdfs:Class ;
rdfs:label "Genetic Disorder" ;
rdfs:comment "A disorder whose etiology involves an abnormality in the nucleotide sequence of an organism's genome." ;
rdfs:subClassOf obo:DOID_4 , obo:SCDO_0000444 .
obo:HP_0003158 a rdfs:Class ;
rdfs:label "Hyposthenuria" ;
rdfs:comment "An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine." ;
rdfs:subClassOf obo:HP_0004727 .
obo:HP_0002650 a rdfs:Class ;
rdfs:label "Scoliosis" ;
rdfs:comment "The presence of an abnormal lateral curvature of the spine." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_0000322 a rdfs:Class ;
rdfs:label "D57.3 Sickle-cell trait" ;
rdfs:comment "The condition of being heterozygous for hemoglobin S." ;
rdfs:subClassOf obo:SCDO_0000311 .
obo:SCDO_1000053 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype SS" ;
rdfs:comment "The homozygous genotype that involves a substitution of glutamic acid for a valine at position 6 of beta-globin chains produced by both beta-globin gene (HBB) alleles." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:HP_0001371 a rdfs:Class ;
rdfs:label "Flexion Contracture" ;
rdfs:comment "A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints." ;
rdfs:subClassOf obo:HP_0000924 .
obo:HP_0003126 a rdfs:Class ;
rdfs:label "Tubular Proteinuria" ;
rdfs:comment "Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD)." ;
rdfs:subClassOf obo:SCDO_0000932 .
obo:SCDO_1000013 a rdfs:Class ;
rdfs:label "HBB" ;
rdfs:comment "This gene encodes the hemoglobin subunit beta and is located on chromosome 11 mapped at 11p15.5." ;
rdfs:subClassOf obo:SCDO_1000362 .
obo:SCDO_0000131 a rdfs:Class ;
rdfs:label "Birthplace of Paternal Grandmother" ;
rdfs:comment "The country in which the respondent's biological paternal (on the father's side of the family) grandmother was born." ;
rdfs:subClassOf obo:SCDO_0000126 .
obo:SCDO_0000937 a rdfs:Class ;
rdfs:label "Psychological Stress" ;
rdfs:comment "Stress wherein emotional factors predominate." ;
rdfs:subClassOf obo:SCDO_0000746 .
obo:DUO_0000019 a rdfs:Class ;
rdfs:label "Publication Required" ;
rdfs:comment "This requirement indicates that requestor agrees to make results of studies using the data available to the larger scientific community." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_1000858 a rdfs:Class ;
rdfs:label "First Name" ;
rdfs:comment "A first name is a name that denotes a specific individual between members of a group of individuals, whose members usually share the same surname." ;
rdfs:subClassOf obo:NCIT_C25191 .
obo:HP_0003470 a rdfs:Class ;
rdfs:label "Paralysis" ;
rdfs:comment "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Motor paralysis is often accompanied by an impairment in the facility of movement." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_1000242 a rdfs:Class ;
rdfs:label "Autosomal Recessive Homozygous" ;
rdfs:comment "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are homozygotes (having two copies of the same mutant allele)." ;
rdfs:subClassOf obo:HP_0000007 .
obo:SCDO_0000580 a rdfs:Class ;
rdfs:label "Hydroxyurea" ;
rdfs:comment "An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0000922 .
obo:SCDO_0007495 a rdfs:Class ;
rdfs:label "Risk" ;
rdfs:comment "The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:SCDO_1000143 a rdfs:Class ;
rdfs:label "Disease Management Guideline" ;
rdfs:comment "A recommendation on the appropriate treatment and care of people with a specific disease or condition, based on the best available evidence, designed to help healthcare professionals in their work." ;
rdfs:subClassOf obo:SCDO_1000160 .
obo:SCDO_0000520 a rdfs:Class ;
rdfs:label "Hemoglobin C Trait" ;
rdfs:comment "The inheritance of the gene for hemoglobin C from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ;
rdfs:subClassOf obo:NCIT_C95534 .
obo:SCDO_1000026 a rdfs:Class ;
rdfs:label "obsolete ICE (individual clinical experience)" ;
rdfs:comment "'Can be used for annotations based on individual clinical experience. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:SCDO_1000553 a rdfs:Class ;
rdfs:label "Diagnosis Descriptor" ;
rdfs:comment "Information or a description that further describes a diagnosis." ;
rdfs:subClassOf obo:SCDO_0000379 .
obo:SCDO_1000832 a rdfs:Class ;
rdfs:label "Normal Serum Alkaline Phosphatase" ;
rdfs:comment "When the level of serum alkaline aminotransferase is in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:HP_0001370 a rdfs:Class ;
rdfs:label "Rheumatoid Arthritis" ;
rdfs:comment "An autoimmune response that primarily affects connective tissue; it also results in chronic inflammation of the joints, especially of the hands and feet and may also cause inflammation of the tissue around the joints, as well as other organs in the body." ;
rdfs:subClassOf obo:HP_0001369 , obo:HP_0002715 .
obo:UO_0000009 a rdfs:Class ;
rdfs:label "Kilogram" ;
rdfs:comment "A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France." ;
rdfs:subClassOf obo:UO_0000002 .
obo:NCIT_C155932 a rdfs:Class ;
rdfs:label "Global Mental Status Screener - Older Children and Adolescents" ;
rdfs:comment "A clinician-assessed rating of psychological and social functioning in children ages six to seventeen that was developed by Shaffer et al. in 1983. The numerical scale, which is an adaptation of the adult Global Assessment Scale (GAS) developed by Endicott et al in 1976, is scored from 0 to 100 based on behaviors and life situations that are applicable to children." ;
rdfs:subClassOf obo:SCDO_0000455 .
obo:SCDO_1000649 a rdfs:Class ;
rdfs:label "Elevated Serum Creatinine" ;
rdfs:comment "An abnormally increased amount of creatinine in the blood." ;
rdfs:subClassOf obo:HP_0002157 , obo:HP_0012100 .
obo:EUPATH_0000034 a rdfs:Class ;
rdfs:label "Alpha Thalassemia Genotype" ;
rdfs:comment "A genotype information which is about the presence and degree of alpha-thalassemia, a form of thalassemia involving the number of functional HBA1 and HBA2 genes." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:NCIT_C95535 a rdfs:Class ;
rdfs:label "Alpha Thalassemia Trait" ;
rdfs:comment "A condition in which a person has reduced protein production from two of the four alpha-globin alleles." ;
rdfs:subClassOf obo:SCDO_0000551 .
obo:SCDO_0000511 a rdfs:Class ;
rdfs:label "obsolete Hemic and Immune Systems" ;
rdfs:comment "Organs involved in the production of BLOOD, including the cellular and the molecular components essential in providing defense against foreign organisms or substances." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:HP_0000006 a rdfs:Class ;
rdfs:label "Autosomal Dominant" ;
rdfs:comment "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." ;
rdfs:subClassOf obo:HP_0000005 .
obo:SCDO_1000732 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - SickleInAfrica Participant Number" ;
rdfs:comment "The Sickle in Africa core data element that records the unique identifier that was assigned to the study participant's data when it was registered in the SickleInAfrica data registry." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000548 a rdfs:Class ;
rdfs:label "Hemoglobin S Test" ;
rdfs:comment "A test to quantify the presence of hemoglobin S in the blood and therefore determine whether a person has sickle cell trait or sickle cell disease." ;
rdfs:subClassOf obo:SCDO_0000522 .
obo:SCDO_1000123 a rdfs:Class ;
rdfs:label "Kalenjin" ;
rdfs:comment "The Kalenjin ethnic group are one of the five largest ethnic groups in Kenya. They are a Nilotic ethnic group and they are mainly farmers." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:HP_0012735 a rdfs:Class ;
rdfs:label "Cough" ;
rdfs:comment "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." ;
rdfs:subClassOf obo:HP_0002086 .
obo:SCDO_0001140 a rdfs:Class ;
rdfs:label "Tertiary Healthcare" ;
rdfs:comment "Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems." ;
rdfs:subClassOf obo:SCDO_0000494 .
obo:HP_0001279 a rdfs:Class ;
rdfs:label "Syncope" ;
rdfs:comment "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_0001117 a rdfs:Class ;
rdfs:label "Stuttering Priapism" ;
rdfs:comment "The occurrence of multiple self-limited episodes of unwanted, often painful erections lasting <4 hours." ;
rdfs:subClassOf obo:SCDO_0000923 .
obo:HP_0004312 a rdfs:Class ;
rdfs:label "Abnormality of Reticulocytes" ;
rdfs:comment "A reticulocyte abnormality." ;
rdfs:subClassOf obo:HP_0001877 .
obo:SCDO_1000328 a rdfs:Class ;
rdfs:label "Past 30-Day Every-Day Smoker" ;
rdfs:comment "A person who had smoked every day of the past 30 days at the time of the interview." ;
rdfs:subClassOf obo:SCDO_0000235 .
obo:SCDO_0000505 a rdfs:Class ;
rdfs:label "Hematology Screening Test" ;
rdfs:comment "A test to detect potential blood disorders or diseases in people who do not have any symptoms of disease." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_1000601 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Pneumococcal Vaccination Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether the respondent's pneumococcal vaccination is up to date." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000436 a rdfs:Class ;
rdfs:label "Enzymatic Assay" ;
rdfs:comment "A method used to measure the relative activity of a specific enzyme or its concentration in solution. Typically an enzyme substrate is added to a buffer solution containing enzyme and the rate of conversion of substrate to product is measured under controlled conditions. Many classical enzymatic assay methods involve the use of synthetic colorimetric substrates and measuring the reaction rates using a spectrophotometer." ;
rdfs:subClassOf obo:SCDO_0000120 .
obo:SCDO_0000455 a rdfs:Class ;
rdfs:label "Global Mental Status Screener" ;
rdfs:comment "A test to assess the respondent's overall mental capability." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_1000821 a rdfs:Class ;
rdfs:label "Normal Hematopoietic System Phenotype" ;
rdfs:comment "A phenotype of the body's hematopoietic system that is not clinically abnormal." ;
rdfs:subClassOf obo:SCDO_1000820 .
obo:SCDO_0000124 a rdfs:Class ;
rdfs:label "Birthplace of Biological Father" ;
rdfs:comment "The country in which the respondent's biological father was born." ;
rdfs:subClassOf obo:SCDO_0000129 .
obo:SCDO_0000055 a rdfs:Class ;
rdfs:label "Angiotensin-Converting Enzyme Inhibitors" ;
rdfs:comment "A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility." ;
rdfs:subClassOf obo:SCDO_0000067 .
obo:SCDO_0000656 a rdfs:Class ;
rdfs:label "Intracranial Hypotension" ;
rdfs:comment "CSF pressure less than 6 cm of H2O in patients with clinical presentation compatible with intracranial hypotension, which are postural headache, nausea, vomiting, neck pain, visual and hearing disturbances, and vertigo. It most commonly results from CSF leaks somewhere along the neuraxis." ;
rdfs:subClassOf obo:HP_0012638 .
obo:ICO_0000157 a rdfs:Class ;
rdfs:label "Parental Consent" ;
rdfs:comment "An informed consent by the parent/guardian of a child or a minor to consent to give permission for the child/minor to be included in research." ;
rdfs:subClassOf obo:SCDO_0003712 , obo:SCDO_0007087 .
obo:SCDO_0000782 a rdfs:Class ;
rdfs:label "MYB" ;
rdfs:comment "This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants." ;
rdfs:subClassOf obo:SCDO_0000810 .
obo:SCDO_0000286 a rdfs:Class ;
rdfs:label "Coping Skill" ;
rdfs:comment "A state of harmony between internal needs and external demands and the processes used in achieving this condition." ;
rdfs:subClassOf obo:SCDO_0000746 .
obo:SCDO_0000324 a rdfs:Class ;
rdfs:label "D57.40 Sickle-cell thalassemia without crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000323 .
obo:OGMS_0000088 a rdfs:Class ;
rdfs:label "Patient Symptom Report" ;
rdfs:comment "A communication from a patient about something they perceive as being abnormal about their body or life." ;
rdfs:subClassOf obo:SCDO_0000738 .
obo:SCDO_0000213 a rdfs:Class ;
rdfs:label "Cerebrovascular Hemodynamics" ;
rdfs:comment "The movement and the forces involved in the movement of the blood through the blood vessels in the brain." ;
rdfs:subClassOf obo:CMO_0000195 .
obo:SCDO_0000559 a rdfs:Class ;
rdfs:label "Hereditary Methemoglobinemia" ;
rdfs:comment "A rare red cell disorder classified principally into two clinical phenotypes: autosomal recessive congenital (or hereditary) methemoglobinemia types I and II (RCM/RHM type 1; RCM/RHM type 2)." ;
rdfs:subClassOf obo:SCDO_0000753 .
obo:SCDO_1000429 a rdfs:Class ;
rdfs:label "Medical Ethics" ;
rdfs:comment "The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families." ;
rdfs:subClassOf obo:SCDO_0006706 .
obo:SCDO_1000727 a rdfs:Class ;
rdfs:label "Methemoglobin to Total Hemoglobin Ratio" ;
rdfs:comment "The ratio of methemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage." ;
rdfs:subClassOf obo:CMO_0000508 .
obo:SCDO_1000703 a rdfs:Class ;
rdfs:label "Hemoglobin G-Philadelphia Level" ;
rdfs:comment "The amount of hemoglobin G-Philadelphia present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:DOID_4 a rdfs:Class ;
rdfs:label "Disease" ;
rdfs:comment "A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_1000072 a rdfs:Class ;
rdfs:label "Hemoglobin Jamaica Plain" ;
rdfs:comment "A sickling hemoglobin with reduced oxygen affinity that causes severe hemolytic anemia and sickling of erythrocytes." ;
rdfs:subClassOf obo:SCDO_1000082 .
obo:SCDO_1000161 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype AS" ;
rdfs:comment "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains of hemoglobin S. Individuals with this genotype are known to be carriers of the sickle cell trait." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:HP_0030680 a rdfs:Class ;
rdfs:label "Abnormal Cardiovascular System Morphology" ;
rdfs:comment "Any structural anomaly of the heart and great vessels." ;
rdfs:subClassOf obo:HP_0001626 .
obo:NCIT_C141366 a rdfs:Class ;
rdfs:label "Hemoglobin Lepore Syndrome" ;
rdfs:comment "A rare autosomal recessive hemoglobinopathy, caused by the presence of two deltabeta globin fusion chains, which occurs due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis." ;
rdfs:subClassOf obo:SCDO_0000343 .
obo:SCDO_0009786 a rdfs:Class ;
rdfs:label "Other HBB Variants" ;
rdfs:comment "A genetic mutation in the HBB gene that results in absent or decreased hemoglobin subunit beta or an abnormal hemoglobin other than Hb S." ;
rdfs:subClassOf obo:SCDO_1000038 .
obo:SCDO_1000460 a rdfs:Class ;
rdfs:label "Prospective Informed Consent" ;
rdfs:comment "Informed consent given prior to enrollment." ;
rdfs:subClassOf obo:SCDO_0007087 , obo:SCDO_1000458 .
obo:SCDO_1000064 a rdfs:Class ;
rdfs:label "Tiered Consent" ;
rdfs:comment "A consent model in which participants are given a set of options allowing them to select how they want to participate in the research." ;
rdfs:subClassOf obo:NCIT_C25460 .
obo:SCDO_1000291 a rdfs:Class ;
rdfs:label "Hemoglobin O-Arab Present" ;
rdfs:comment "When the abnormal hemoglobin, hemoglobin O-Arab (Hb O-Arab), has been detected in a blood sample." ;
rdfs:subClassOf obo:HP_0020061 .
obo:SCDO_0000227 a rdfs:Class ;
rdfs:label "deprecated-Chronic Kidney Injury" ;
rdfs:comment "Is a long-term condition where the kidneys don't work as well as they should." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:UO_0000187 a rdfs:Class ;
rdfs:label "Percent" ;
rdfs:comment "A dimensionless ratio unit which denotes numbers as fractions of 100." ;
rdfs:subClassOf obo:UO_0000190 .
obo:SCDO_0001384 a rdfs:Class ;
rdfs:label "Reduced Alpha/Gamma Synthesis Ratio" ;
rdfs:comment "A reduction in the ratio of production of alpha globin to that of gamma globin." ;
rdfs:subClassOf obo:HP_0005560 .
obo:HP_0002067 a rdfs:Class ;
rdfs:label "Bradykinesia" ;
rdfs:comment "Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement)." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_1000805 a rdfs:Class ;
rdfs:label "D57.813 Other sickle-cell disorders with cerebral vascular involvement" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000331 .
obo:SCDO_0002305 a rdfs:Class ;
rdfs:label "Hemoglobin D Disease Causal Mutation" ;
rdfs:comment "A mutation wholly or partly responsible for causing Hemoglobin D Disease." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_0000500 a rdfs:Class ;
rdfs:label "Heart Function Test" ;
rdfs:comment "Examinations used to diagnose and treat heart conditions." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_1000024 a rdfs:Class ;
rdfs:label "obsolete IEA (inferred from electronic annotation)" ;
rdfs:comment "'Used for annotations that depend directly on computation or automated transfer of annotations from a database, particularly when the analysis is performed internally and not published. A key feature that distinguishes this evidence code from others is that it is not made by a curator; use IEA when no curator has checked the specific annotation to verify its accuracy. [Curator team: Exact []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:SCDO_0000444 a rdfs:Class ;
rdfs:label "Genetic Disease Modifier" ;
rdfs:comment "A biological disease modifier that is of a genetic nature." ;
rdfs:subClassOf obo:SCDO_0000122 .
obo:OGMS_0000023 a rdfs:Class ;
rdfs:label "Phenotype" ;
rdfs:comment "A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:SCDO_0001076 a rdfs:Class ;
rdfs:label "Sleep Disorders Screener - Adult" ;
rdfs:comment "An interviewer-administered questionnaire which captures routine sleep schedule, sleep deprivation, morningness-eveningness, insomnia, narcolepsy, cataplexy and associated distress." ;
rdfs:subClassOf obo:SCDO_1000348 .
obo:SCDO_0000192 a rdfs:Class ;
rdfs:label "Causal Adverse Drug Event Due to Drug-Drug Interaction" ;
rdfs:comment "A causal adverse drug event that is induced by a drug-drug interaction." ;
rdfs:subClassOf obo:SCDO_0000191 .
obo:SCDO_0004623 a rdfs:Class ;
rdfs:label "Codon" ;
rdfs:comment "Also known as sense codon, a set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (terminator codon). Most codons are universal, but some organisms do not produce the transfer RNAs complementary to all codons. These codons are referred to as unassigned codons (nonsense codons)." ;
rdfs:subClassOf obo:SCDO_0005593 .
obo:SCDO_1000691 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin A Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001002 a rdfs:Class ;
rdfs:label "Restriction Fragment Length Polymorphism PCR" ;
rdfs:comment "PCR-restriction fragment length polymorphism (RFLP)-based analysis, also known as cleaved amplified polymorphic sequence (CAPS), is a popular technique for genetic analysis. It has been applied for the detection of intraspecies as well as interspecies variation. There exist several techniques that are related with PCR-RFLP and also involve gel electrophoresis including techniques for DNA fingerprinting and expression profiling." ;
rdfs:subClassOf obo:SCDO_0000913 .
obo:SCDO_1000150 a rdfs:Class ;
rdfs:label "Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada" ;
rdfs:comment "Standard of care guidelines that promote excellence in sickle cell care, and that lead to improved patient experiences around care and treatment." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:OBI_0000626 a rdfs:Class ;
rdfs:label "DNA Sequencing" ;
rdfs:comment "A sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument." ;
rdfs:subClassOf obo:SCDO_0000448 .
obo:SCDO_0007281 a rdfs:Class ;
rdfs:label "Adrenal Insufficiency" ;
rdfs:comment "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves." ;
rdfs:subClassOf obo:HP_0000834 .
obo:SCDO_0000112 a rdfs:Class ;
rdfs:label "Beta Thalassemia Intermedia" ;
rdfs:comment "A homozygous (B+/B+) or compound heterozygous (B0/B+) form of beta-thalassemia characterized by mild to moderate anemia which does not or only occasionally requires transfusion." ;
rdfs:subClassOf obo:SCDO_0000251 .
obo:SCDO_1000050 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype S/D-Punjab" ;
rdfs:comment "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin D-Punjab (HBB Glu121Gln) variants." ;
rdfs:subClassOf obo:SCDO_1000054 .
obo:SCDO_1000680 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Total Bilirubin Concentration Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the level of billirubin in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:NCIT_C51993 a rdfs:Class ;
rdfs:label "Antibiotic Prophylaxis" ;
rdfs:comment "Administration of antibiotics with the intent of preventing bacterial infection." ;
rdfs:subClassOf obo:SCDO_0000930 .
obo:SCDO_1000566 a rdfs:Class ;
rdfs:label "Date of Blood Transfusion" ;
rdfs:comment "The date on which a patient received a blood transfusion." ;
rdfs:subClassOf obo:SCDO_1000537 , obo:SCDO_1000590 .
obo:SCDO_0001373 a rdfs:Class ;
rdfs:label "deprecated beta C mutation" ;
rdfs:comment "'To be defined by an expert [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0000096 a rdfs:Class ;
rdfs:label "Glomerulosclerosis" ;
rdfs:comment "Scarring and fibrosis within the glomerulus." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_0001098 a rdfs:Class ;
rdfs:label "Spirituality" ;
rdfs:comment "Sensitivity or attachment to religious values, or to things of the spirit as opposed to material or worldly interests." ;
rdfs:subClassOf obo:SCDO_0000299 .
obo:SCDO_0000376 a rdfs:Class ;
rdfs:label "Diagnostic Device" ;
rdfs:comment "A medical device used to diagnose medical conditions." ;
rdfs:subClassOf obo:SCDO_0000379 .
obo:SCDO_0000516 a rdfs:Class ;
rdfs:label "deprecated Hemoglobin A2 Profile" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0000217 a rdfs:Class ;
rdfs:label "Chest X-Ray" ;
rdfs:comment "A medical imaging assessment of the chest wall, airways, lungs, pulmonary vessels, heart, mediastinum, and pleura." ;
rdfs:subClassOf obo:SCDO_0000963 .
obo:HP_0031456 a rdfs:Class ;
rdfs:label "Ectopic Pregnancy" ;
rdfs:comment "A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube)." ;
rdfs:subClassOf obo:NCIT_C34941 , obo:SCDO_1000371 .
obo:SCDO_0000975 a rdfs:Class ;
rdfs:label "Red Blood Cell Microparticles Level" ;
rdfs:comment "The amount of red blood cell derived microparticles in a specific volume of blood." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:NCIT_C38698 a rdfs:Class ;
rdfs:label "Hyperviscosity" ;
rdfs:comment "An increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity." ;
rdfs:subClassOf obo:HP_0001871 .
obo:SCDO_0001087 a rdfs:Class ;
rdfs:label "Social Skill" ;
rdfs:comment "The personal set of abilities required to successfully interact and communicate with others, both verbally and non-verbally through gestures, body language and personal appearance." ;
rdfs:subClassOf obo:SCDO_0001083 .
obo:SCDO_0000414 a rdfs:Class ;
rdfs:label "Education" ;
rdfs:comment "Acquisition of knowledge as a result of instruction in a formal course of study." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:SCDO_1000301 a rdfs:Class ;
rdfs:label "Hepatitis B Blood Panel" ;
rdfs:comment "A set of three blood tests (Hepatitis B Core Antibody Test, Hepatitis B Surface Antibody Test, and Hepatitis B Virus Surface Antigen Test) needed to fully understand whether a person is infected with Hepatitis B or not." ;
rdfs:subClassOf obo:SCDO_0000616 .
obo:NCIT_C95539 a rdfs:Class ;
rdfs:label "Sickle Beta Thalassemia" ;
rdfs:comment "A compound heterozygous state in which a person has a hemoglobin S allele along with a beta-thalassemia allele. The severity of the condition is determined to a large extent by the quantity of normal hemoglobin produced by the beta-thalassemia gene." ;
rdfs:subClassOf obo:SCDO_0007656 .
obo:SCDO_1000333 a rdfs:Class ;
rdfs:label "Global Mental Status Screener - Child" ;
rdfs:comment "A series of 21 age-specific questionnaires and scoring sheets designed to screen a child's skills in five developmental areas: fine motor, gross motor, problem solving, communication, and personal-social. A child's scores for each area are compared to cut-off scores to determine a need for monitoring or further assessment." ;
rdfs:subClassOf obo:SCDO_0000455 .
obo:HP_0000828 a rdfs:Class ;
rdfs:label "Abnormality of the Parathyroid Gland" ;
rdfs:comment "An abnormality of the parathyroid gland." ;
rdfs:subClassOf obo:HP_0000818 .
obo:SCDO_1000497 a rdfs:Class ;
rdfs:label "True-False Question" ;
rdfs:comment "A dichotomous question that has answer options \"true\" and \"false\"." ;
rdfs:subClassOf obo:SCDO_1000494 .
obo:SCDO_0000297 a rdfs:Class ;
rdfs:label "Crisis Intervention" ;
rdfs:comment "Brief therapeutic approach which is ameliorative rather than curative of acute psychiatric emergencies. Used in contexts such as emergency rooms of psychiatric or general hospitals, or in the home or place of crisis occurrence, this treatment approach focuses on interpersonal and intrapsychic factors and environmental modification. (APA Thesaurus of Psychological Index Terms, 7th ed)" ;
rdfs:subClassOf obo:SCDO_0000940 .
obo:NCIT_C15900 a rdfs:Class ;
rdfs:label "Lifestyle Therapy" ;
rdfs:comment "Therapy dealing with lifestyle management and includes: behavioral and dietary modifications, exercise, stress management, and addiction control. This therapy must be used as major adjunct to 'standard care' or be applied as alternative treatment to conventional medicine practices." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:SCDO_0000126 a rdfs:Class ;
rdfs:label "Birthplace of Grandparents" ;
rdfs:comment "The country or countires in which the respondent's biological grandparents were born." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:SCDO_0000257 a rdfs:Class ;
rdfs:label "obsolete Clinical Trial, Phase IV" ;
rdfs:comment "'Work that is a report of a planned post-marketing study of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale after clinical trials, phases I, II, and III. These studies, conducted in the United States or a foreign country, often garner additional data about the safety and efficacy of a product. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000254 .
obo:NCIT_C19771 a rdfs:Class ;
rdfs:label "Molecular Profiling Assay" ;
rdfs:comment "Analysis of the RNA expression pattern in a tissue sample using molecular techniques." ;
rdfs:subClassOf obo:SCDO_0000082 .
obo:SCDO_0000526 a rdfs:Class ;
rdfs:label "deprecated Hemoglobin D-Beta Thalassemia" ;
rdfs:comment "'Hemoglobin D/xcexb2xc2xb0 thalassemia is a form of beta-thalassemia which results in a mild to moderate clinical picture. The severity of the condition depends on the degree of thalassemia and how it affects production of Hemoglobin A, however this condition is often considered fairly benign.'" ;
rdfs:subClassOf obo:SCDO_0000272 .
obo:SCDO_1000344 a rdfs:Class ;
rdfs:label "Reproductive History Diagnostic Instrument - Male" ;
rdfs:comment "A questionnaire to assess males' pregnancy history." ;
rdfs:subClassOf obo:SCDO_0000987 .
obo:HP_0000027 a rdfs:Class ;
rdfs:label "Azoospermia" ;
rdfs:comment "Absence of any measurable level of sperm in a male's semen." ;
rdfs:subClassOf obo:HP_0000080 .
obo:SCDO_0003065 a rdfs:Class ;
rdfs:label "obsolete Non-SCD Structural Variants" ;
rdfs:comment "Genetic variation in the structure leading to the abnomality of protein structure in non-sickle cell disease hemoglobin." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000577 a rdfs:Class ;
rdfs:label "Type of SCD Test" ;
rdfs:comment "The type of test that was used to obtain a sickle cell disease diagnosis." ;
rdfs:subClassOf obo:SCDO_1000576 .
obo:SCDO_0000533 a rdfs:Class ;
rdfs:label "deprecated Hemoglobin F Profile" ;
rdfs:comment "The score of fetal hemoglobin (Hb F) in the blood of an individual." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0004379 a rdfs:Class ;
rdfs:label "Abnormality of Alkaline Phosphatase Level" ;
rdfs:comment "An abnormality of alkaline phosphatase level." ;
rdfs:subClassOf obo:HP_0012379 .
obo:NCIT_C25460 a rdfs:Class ;
rdfs:label "Consent" ;
rdfs:comment "Permission to do something." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_0007597 .
obo:CMO_0000376 a rdfs:Class ;
rdfs:label "Total Serum Bilirubin Level" ;
rdfs:comment "The complete or entire amount of bilirubin in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Bilirubin is the bile pigment produced by breakdown of heme and reduction of biliverdin." ;
rdfs:subClassOf obo:CMO_0000123 .
obo:OBI_0002140 a rdfs:Class ;
rdfs:label "Temperature Measurement Assay" ;
rdfs:comment "An assay to determine the temperature of an evaluant." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_1000082 a rdfs:Class ;
rdfs:label "Sickling Hemoglobin with Two Beta-Globin Gene Substitutions" ;
rdfs:comment "A hemoglobin that sickles due to the presence of two beta-globin gene mutations within the same HBB gene." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_0003807 .
obo:SCDO_0000803 a rdfs:Class ;
rdfs:label "Neonatal Screening for Sickle Cell" ;
rdfs:comment "Testing of neonates to identify those with major sickling diseases." ;
rdfs:subClassOf obo:SCDO_0001049 .
obo:HP_0000123 a rdfs:Class ;
rdfs:label "Nephritis" ;
rdfs:comment "The presence of inflammation affecting the kidney." ;
rdfs:subClassOf obo:HP_0000077 , obo:HP_0002715 , obo:SCDO_1000383 .
obo:SCDO_1000501 a rdfs:Class ;
rdfs:label "Open-Ended Question - Restricted" ;
rdfs:comment "A open ended question that restricts the nature of the text answer that can be provided by the respondent." ;
rdfs:subClassOf obo:SCDO_1000493 .
obo:SCDO_0000267 a rdfs:Class ;
rdfs:label "Comorbid Disease" ;
rdfs:comment "A co-existing or additional disease with reference to an initial diagnosis or with reference to the index condition that is the subject of study." ;
rdfs:subClassOf obo:DOID_4 , obo:OGMS_0000023 .
obo:SCDO_1000306 a rdfs:Class ;
rdfs:label "Hepatitis C Virus Antigen Test" ;
rdfs:comment "The determination of the amount of hepatitis C virus antigen present in a sample." ;
rdfs:subClassOf obo:SCDO_0000616 .
obo:SCDO_1000396 a rdfs:Class ;
rdfs:label "Gene Enhancer" ;
rdfs:comment "A gene enhancer is a short region of DNA that can be bound with proteins to enhance transcription levels of genes in a gene cluster." ;
rdfs:subClassOf obo:SCDO_1000395 .
obo:SCDO_0000527 a rdfs:Class ;
rdfs:label "Hemoglobin D-Ibadan" ;
rdfs:comment "An unusual hemoglobin that shows all the electrophoretic features of Hb D, but has no inherited disability. This hemoglobin has a beta 87 Thr > Lys mutation." ;
rdfs:subClassOf obo:SCDO_1000259 .
obo:SCDO_0007618 a rdfs:Class ;
rdfs:label "deprecated-Avascular necrosis of the humeral head" ;
rdfs:comment "In situ death of bone within the humeral head due to disruption of blood supply." ;
rdfs:subClassOf obo:NCIT_C118385 .
obo:SCDO_0000163 a rdfs:Class ;
rdfs:label "Brief Illness Perception Questionnaire (B-IPQ)" ;
rdfs:comment "The Brief IPQ has 9 items, 8 new items from the IPQ plus a causal question. All of the items except the causal question are rated using a 0-to-10-response scale. Five of the items assess Cognitive Illness Representations: Consequences (Item 1), Timeline (Item 2), Personal Control (Item 3), Treatment Control (Item 4), and Identity (Item 5). Two of the items assess Emotional Representations: Concern (Item 6) and Emotions (Item 8). One item assesses Illness Comprehensibility (Item 7). Assessment of the Causal Representation is by an open-ended response item adapted, which asks patients to list the three most important causal factors in their illness (Item 9). Responses to the causal item can be grouped into categories such as stress, lifestyle, hereditary, etc, determined by the particular illness studied, and categorical analysis can then be performed." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:HP_0008245 a rdfs:Class ;
rdfs:label "Secondary Hypothyroidism" ;
rdfs:comment "A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion." ;
rdfs:subClassOf obo:HP_0000821 .
obo:SCDO_0009731 a rdfs:Class ;
rdfs:label "Beta Thalassemia Mutation" ;
rdfs:comment "A mutation in the beta-globin gene, HBB, that causes decreased or absent beta-globin synthesis." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:EUPATH_0021227 a rdfs:Class ;
rdfs:label "Blood Urea Concentration" ;
rdfs:comment "A scalar measurement datum of the concentration of urea in blood that is a specified output of a blood test." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:NCIT_C35447 a rdfs:Class ;
rdfs:label "Osteonecrosis of the Femoral Head" ;
rdfs:comment "Necrotic changes in the bone tissue of the femoral head due to interruption of blood supply." ;
rdfs:subClassOf obo:HP_0010885 .
obo:NCIT_C124059 a rdfs:Class ;
rdfs:label "Pulmonary Consolidation" ;
rdfs:comment "A chest X-ray finding indicating the presence of a radio-opaque area in the lung. The opacification is caused by fluid or solid material within the airways or lung parenchyma." ;
rdfs:subClassOf obo:HP_0030680 .
obo:SCDO_0300004 a rdfs:Class ;
rdfs:label "Epidemiologic Study Characteristics" ;
rdfs:comment "Types and formulations of studies used in epidemiological and clinical research." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_0000365 a rdfs:Class ;
rdfs:label "Dexterity" ;
rdfs:comment "Skill in performing tasks, especially with the hands." ;
rdfs:subClassOf obo:SCDO_0000900 .
obo:SCDO_1000844 a rdfs:Class ;
rdfs:label "Hemoglobin S Present" ;
rdfs:comment "When the abnormal hemoglobin, hemoglobin S (HbS), has been detected in a blood sample." ;
rdfs:subClassOf obo:HP_0020061 .
obo:SCDO_0004905 a rdfs:Class ;
rdfs:label "Beta-Globin Locus Deletion" ;
rdfs:comment "Deletion of a part of the beta-globin locus." ;
rdfs:subClassOf obo:NCIT_C19296 .
obo:SCDO_0000152 a rdfs:Class ;
rdfs:label "Body Weight" ;
rdfs:comment "The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms." ;
rdfs:subClassOf obo:CMO_0000011 .
obo:SCDO_0000917 a rdfs:Class ;
rdfs:label "Pragmatic Clinical Trial" ;
rdfs:comment "'Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000965 .
obo:SCDO_0001319 a rdfs:Class ;
rdfs:label "Fatigue" ;
rdfs:comment "Inability to function due to tiredness related to sickle cell disease." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:HP_0025142 , obo:SCDO_0000954 .
obo:SCDO_1000007 a rdfs:Class ;
rdfs:label "Hemoglobin D" ;
rdfs:comment "An abnormal hemoglobin caused by various point mutations within the HBB gene. This form of hemoglobin prevents red blood cells from carrying oxygen effectively. There are at least 8 different types of hemoglobin D." ;
rdfs:subClassOf obo:SCDO_0003807 .
obo:SCDO_1000725 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Carboxyhemoglobin Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's carboxyhemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001029 a rdfs:Class ;
rdfs:label "Sedentary Lifestyle" ;
rdfs:comment "Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week." ;
rdfs:subClassOf obo:SCDO_0000689 .
obo:ICO_0000304 a rdfs:Class ;
rdfs:label "Description of Future Data Use" ;
rdfs:comment "A descriptive information content entity that describes how data will be used." ;
rdfs:subClassOf obo:ICO_0000305 .
obo:NCIT_C154481 a rdfs:Class ;
rdfs:label "Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)" ;
rdfs:comment "A patient-reported outcome measurement system designed to evaluate and monitor the physical, mental, and social well-being of adults with sickle cell disease." ;
rdfs:subClassOf obo:SCDO_0000952 .
obo:SCDO_0000419 a rdfs:Class ;
rdfs:label "Electroencephalograph" ;
rdfs:comment "An instrument that measures electrical potentials on the scalp and generates a record of the electrical activity of the brain." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:CMO_0000365 a rdfs:Class ;
rdfs:label "Total White Blood Cell Count" ;
rdfs:comment "The total number of leukocytes in 1 cubic millimeter of peripheral venous blood." ;
rdfs:subClassOf obo:CMO_0000027 .
obo:SCDO_1000709 a rdfs:Class ;
rdfs:label "Sex of Partner" ;
rdfs:comment "The sex of the respondent's partner (where the partner is not a spouse), as provided by the respondent." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:SCDO_1000317 a rdfs:Class ;
rdfs:label "Heart Measurement" ;
rdfs:comment "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart." ;
rdfs:subClassOf obo:CMO_0000001 .
obo:HP_0100602 a rdfs:Class ;
rdfs:label "Preeclampsia" ;
rdfs:comment "Pregnancy-induced hypertension in association with significant amounts of protein in the urine." ;
rdfs:subClassOf obo:NCIT_C34941 , obo:SCDO_0000267 , obo:SCDO_1000371 .
obo:NCIT_C28516 a rdfs:Class ;
rdfs:label "Sickle Cell Dactylitis" ;
rdfs:comment "A severe acute inflammatory response affecting the hands and feet of individuals with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and finally infarction of the distal portions of the extremities. Clinical signs of pain, swelling and tenderness of digits usually begin in early childhood and may be the initial manifestations of sickle cell anemia. Clinical course is self-limited with instances typically lasting a few weeks and occurring during sickling crises. An initial episode before the age of 1 strongly correlates with a more severe disease course." ;
rdfs:subClassOf obo:HP_0002715 , obo:SCDO_0001023 .
obo:PR_000001318 a rdfs:Class ;
rdfs:label "L-Selectin" ;
rdfs:comment "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." ;
rdfs:subClassOf obo:NCIT_C26548 .
obo:HP_0001507 a rdfs:Class ;
rdfs:label "Growth Abnormality" ;
rdfs:comment "Abnormality of growth." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0001034 a rdfs:Class ;
rdfs:label "Self Care" ;
rdfs:comment "Caring for self when ill or positive actions and adopting behaviors to prevent illness." ;
rdfs:subClassOf obo:SCDO_0000978 .
obo:HP_0001342 a rdfs:Class ;
rdfs:label "Cerebral Hemorrhage" ;
rdfs:comment "Hemorrhage into the parenchyma of the brain." ;
rdfs:subClassOf obo:HP_0002170 .
obo:SCDO_0000104 a rdfs:Class ;
rdfs:label "Behavior Rating Inventory of Executive Function" ;
rdfs:comment "The Behavior Rating Inventory of Executive Function (BRIEF) is a detailed questionnaire designed to assess executive function behaviors of children and adolescents in the school and home environments. The BRIEF is completed by parents and teachers." ;
rdfs:subClassOf obo:SCDO_0001304 .
obo:SCDO_0000488 a rdfs:Class ;
rdfs:label "Health Beliefs" ;
rdfs:comment "People's beliefs about health problems, perceived benefits of action and barriers to action, and self-efficacy." ;
rdfs:subClassOf obo:SCDO_0000299 .
obo:SCDO_0000235 a rdfs:Class ;
rdfs:label "Cigarette Smoking Status" ;
rdfs:comment "An indication of a person's current cigarette use as well as some indication of cigarette smoking history." ;
rdfs:subClassOf obo:NCIT_C29719 , obo:SCDO_1000318 .
obo:HP_0004447 a rdfs:Class ;
rdfs:label "Poikilocytosis" ;
rdfs:comment "The presence of abnormally shaped erythrocytes." ;
rdfs:subClassOf obo:HP_0001877 .
obo:NCIT_C28421 a rdfs:Class ;
rdfs:label "Sex" ;
rdfs:comment "The totality of characteristics of reproductive structure, functions, phenotype, and genotype, differentiating the male from the female organism." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0000122 .
obo:SCDO_1000000 a rdfs:Class ;
rdfs:label "Acute Phenotype" ;
rdfs:comment "An observable characteristic of disease that has a severe and rapid onset of symptoms with short duration." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0000123 a rdfs:Class ;
rdfs:label "Birthplace" ;
rdfs:comment "The country in which the respondent was born." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:SCDO_1000355 a rdfs:Class ;
rdfs:label "Health Facility Environment" ;
rdfs:comment "Physical surroundings or conditions of a hospital or other health facility and influence of these factors on patients and staff." ;
rdfs:subClassOf obo:ExO_0000048 .
obo:HP_0002059 a rdfs:Class ;
rdfs:label "Cerebral Atrophy" ;
rdfs:comment "Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum." ;
rdfs:subClassOf obo:HP_0002060 .
obo:SCDO_1000619 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin - CBC Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the concentration of hemoglobin in the respondent's blood, as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:NCIT_C97120 a rdfs:Class ;
rdfs:label "Pneumococcal 10-Valent Conjugate Vaccine" ;
rdfs:comment "An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It is indicated for disease caused by serotypes 1, 5, 4, 6B, 7, 9V, 14, 18C, 19F, and 23F." ;
rdfs:subClassOf obo:NCIT_C97123 .
obo:HP_0011410 a rdfs:Class ;
rdfs:label "Caesarian Section" ;
rdfs:comment "Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy)." ;
rdfs:subClassOf obo:HP_0001787 .
obo:DUO_0000027 a rdfs:Class ;
rdfs:label "Project Specific Restriction" ;
rdfs:comment "This requirement indicates that use is limited to use within an approved project." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_1000840 a rdfs:Class ;
rdfs:label "Decreased Partial Pressure of Carbon Dioxide" ;
rdfs:comment "An abnormal reduction in the pressure exerted by carbon dioxide dissolved in the blood." ;
rdfs:subClassOf obo:MP_0002329 .
obo:SCDO_0000130 a rdfs:Class ;
rdfs:label "Birthplace of Paternal Grandfather" ;
rdfs:comment "The country in which the respondent's biological paternal (on the father's side of the family) grandfather was born." ;
rdfs:subClassOf obo:SCDO_0000126 .
obo:SCDO_0007900 a rdfs:Class ;
rdfs:label "Embryonic Hemoglobin" ;
rdfs:comment "Hemoglobin produced in the blood islands in the embryonic yolk sac during the mesoblastic stage of gestation. There are four different embryonic hemoglobins, Hemoglobin Gower 1, Hemoglobin Gower 2, Hemoglobin Portland 1 and Hemoglobin Portland 2." ;
rdfs:subClassOf obo:SCDO_0006835 .
obo:SCDO_0000026 a rdfs:Class ;
rdfs:label "Adult Migraine Questionnaire" ;
rdfs:comment "A 20-item questionnaire that assesses the frequency of severe headaches, the level of pain, whether the person is taking medications, and associated complications such as nausea." ;
rdfs:subClassOf obo:SCDO_0000760 .
obo:SCDO_0000310 a rdfs:Class ;
rdfs:label "Blood Cystatin C Level" ;
rdfs:comment "The amount of the protein cystatin C (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide) found in a specified sample of blood. This extracellular cystatin subtype is abundantly expressed in bodily fluids." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:NCIT_C85397 a rdfs:Class ;
rdfs:label "Spirometry" ;
rdfs:comment "Measurement of the breathing capacity of the lung by means of a spirometer." ;
rdfs:subClassOf obo:SCDO_0000942 .
obo:SCDO_0000313 a rdfs:Class ;
rdfs:label "D57.01 Hb-SS disease with acute chest syndrome" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000312 .
obo:HP_0000938 a rdfs:Class ;
rdfs:label "Osteopenia" ;
rdfs:comment "Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_1000138 a rdfs:Class ;
rdfs:label "Pokot" ;
rdfs:comment "The Pokot are a Kalenjin-speaking people whose language incorporates words from the neighboring Karamojong and Turkana. The Pokot live in an ecologically complex region that extends from the plains of eastern Uganda across the highlands of northwestern Kenya to the plains of Lake Baringo." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_1000800 a rdfs:Class ;
rdfs:label "D57.452 Sickle-cell thalassemia beta plus with splenic sequestration" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000798 .
obo:NCIT_C74096 a rdfs:Class ;
rdfs:label "Voluntary" ;
rdfs:comment "Of your own free will or design; not forced or compelled; controlled by individual volition." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0000953 a rdfs:Class ;
rdfs:label "Quality of Life Measure" ;
rdfs:comment "A measurement tool with eight potential uses in aiding routine clinical practice. It can be used to prioritise problems, facilitate communication, screen for potential problems, identify preferences, monitor changes or response to treatment, and train new staff. It can also be used in clinical audit and in clinical governance. The first five of these can be used in the clinical encounter, while the last three contribute to training, reviewing care, and improving care in the future." ;
rdfs:subClassOf obo:SCDO_0000951 .
obo:CMO_0000030 a rdfs:Class ;
rdfs:label "Blood Neutrophil Count" ;
rdfs:comment "The number of granulocytes categorized as neutrophils in a specified volume of blood. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes." ;
rdfs:subClassOf obo:CMO_0000111 .
obo:SCDO_1000520 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Type of Informed Consent Obtained Question" ;
rdfs:comment "The Sickle in Africa core data element that records the type(s) of informed consent obtained from the participant." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000530 a rdf:Property ;
rdfs:label "max number of selections allowed" ;
rdfs:comment "Records the maximum number of selections that a respondent is allowed to make from a list of multiple answer options provided for a data element." ;
rdfs:range xsd:nonNegativeInteger .
obo:SCDO_1000529 a rdf:Property ;
rdfs:label "min number of selections allowed" ;
rdfs:comment "Records the minimum number of selections that a respondent is allowed to make from a list of multiple answer options provided for a data element." ;
rdfs:range xsd:nonNegativeInteger .
obo:SCDO_0001168 a rdfs:Class ;
rdfs:label "Transient Monocular Blindness" ;
rdfs:comment "Temporary loss of vision in one eye due to a lack of blood flow to the retina." ;
rdfs:subClassOf obo:HP_0000618 .
obo:SCDO_0000007 a rdfs:Class ;
rdfs:label "Abnormal Hemoglobin in SCD" ;
rdfs:comment "A structurally abnormal hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD)." ;
rdfs:subClassOf obo:HP_0001877 , obo:SCDO_1000060 .
obo:SCDO_1000362 a rdfs:Class ;
rdfs:label "Beta-Globin Gene" ;
rdfs:comment "A gene located in the beta-globin locus (or gene cluster) on chromosome 11." ;
rdfs:subClassOf obo:SCDO_1000360 .
obo:HP_0000836 a rdfs:Class ;
rdfs:label "Hyperthyroidism" ;
rdfs:comment "An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3)." ;
rdfs:subClassOf obo:HP_0000820 .
obo:HP_0000080 a rdfs:Class ;
rdfs:label "Abnormality of Reproductive System Physiology" ;
rdfs:comment "An abnormal functionality of the genital system." ;
rdfs:subClassOf obo:HP_0000078 .
obo:SCDO_1000684 a rdfs:Class ;
rdfs:label "Reduced Lactate Dehydrogenase Level" ;
rdfs:comment "A decreased or reduced level of the enzyme lactate dehydrogenase in serum." ;
rdfs:subClassOf obo:HP_0045040 .
obo:NCIT_C1643 a rdfs:Class ;
rdfs:label "Polyvalent Pneumococcal Vaccine" ;
rdfs:comment "An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years." ;
rdfs:subClassOf obo:VO_0000675 .
obo:NCIT_C16676 a rdfs:Class ;
rdfs:label "Hemoglobin" ;
rdfs:comment "The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb." ;
rdfs:subClassOf obo:NCIT_C26548 .
obo:HP_0002007 a rdfs:Class ;
rdfs:label "Frontal Bossing" ;
rdfs:comment "Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_1000471 a rdfs:Class ;
rdfs:label "Country of Data Collection" ;
rdfs:comment "The name of the country where the sample or data was collected." ;
rdfs:subClassOf obo:SCDO_1000401 .
obo:SCDO_0000572 a rdfs:Class ;
rdfs:label "Hospital Anxiety and Depression Scale (HADS)" ;
rdfs:comment "The HADS consists of 2 subscales each with 7 items for measuring anxiety, and 7 items for depression rated from 0 - 3. Anxiety and depression scores are obtained by adding up the ratings of the items on each subscale. A score above 8 in any of the subscales indicates that the patient has experienced clinically significant anxiety or depression over the past week." ;
rdfs:subClassOf obo:SCDO_0000951 , obo:SCDO_1000297 .
obo:SCDO_0001114 a rdfs:Class ;
rdfs:label "Stroke Risk Test in Children with Sickle Cell Disease" ;
rdfs:comment "A clinical test to measure the blood flow velocities in intracranial arteries. Elevated intracranial arterial blood flow rates are indicative of expanding vessel lesions and a subsequent increased risk of stroke." ;
rdfs:subClassOf obo:NCIT_C154865 .
obo:SCDO_1000512 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Informed Consent Obtained Question" ;
rdfs:comment "The Sickle in Africa core data element that records whether the respondent has consented as necessary." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000343 a rdfs:Class ;
rdfs:label "Delta Beta Thalassemia" ;
rdfs:comment "A form of beta-thalassemia characterized by decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis." ;
rdfs:subClassOf obo:SCDO_0000111 .
obo:SCDO_0000515 a rdfs:Class ;
rdfs:label "Hemoglobin H" ;
rdfs:comment "An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in alpha-thalassemia." ;
rdfs:subClassOf obo:SCDO_0003807 .
obo:SCDO_1000323 a rdfs:Class ;
rdfs:label "Current Every-Day Smoker" ;
rdfs:comment "A person who was smoking on a daily basis at the time of the interview." ;
rdfs:subClassOf obo:SCDO_0000235 .
obo:HP_0002060 a rdfs:Class ;
rdfs:label "Abnormality of the Cerebrum" ;
rdfs:comment "An abnormality of the telencephalon, which is also known as the cerebrum." ;
rdfs:subClassOf obo:HP_0012639 .
obo:SCDO_0000447 a rdfs:Class ;
rdfs:label "Genetic Service" ;
rdfs:comment "Organized services to provide diagnosis, treatment, and prevention of genetic disorders." ;
rdfs:subClassOf obo:SCDO_0000922 .
obo:HP_0020058 a rdfs:Class ;
rdfs:label "Abnormal Red Blood Cell Count" ;
rdfs:comment "Any deviation from the normal number of red blood cells per volume in the circulation." ;
rdfs:subClassOf obo:HP_0001877 .
obo:SCDO_1000555 a rdfs:Class ;
rdfs:label "Date of SCD Diagnosis Known" ;
rdfs:comment "An indication of whether the date of the respondent's SCD diagnosis is known by the respondent or the respondent's guardian." ;
rdfs:subClassOf obo:SCDO_1000554 .
obo:HP_0008682 a rdfs:Class ;
rdfs:label "Acute Tubular Necrosis" ;
rdfs:comment "Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis." ;
rdfs:subClassOf obo:SCDO_1000000 .
obo:SCDO_0001067 a rdfs:Class ;
rdfs:label "Sickle Retinopathy" ;
rdfs:comment "Retinal changes of sickle cell disease that can be either proliferative or non-proliferative. In both cases, the changes are caused by erythrostasis secondary to sickling." ;
rdfs:subClassOf obo:HP_0000478 , obo:NCIT_C115319 .
obo:HP_0001974 a rdfs:Class ;
rdfs:label "Leukocytosis" ;
rdfs:comment "An abnormal increase in the number of leukocytes in the blood." ;
rdfs:subClassOf obo:HP_0011893 .
obo:SCDO_1000548 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Current Marital Status Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's current marital status." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001388 a rdfs:Class ;
rdfs:label "Insertion" ;
rdfs:comment "Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt genetic translation of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_1000605 a rdfs:Class ;
rdfs:label "Blood Urea Analysis" ;
rdfs:comment "Any assay which measures the amount, level or concentration of urea in whole blood." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_0001336 a rdfs:Class ;
rdfs:label "from phenotype" ;
rdfs:comment "Terms deprecated in the \"Phenotype\" class." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:CMO_0000037 a rdfs:Class ;
rdfs:label "Hematocrit" ;
rdfs:comment "Percentage of total blood volume that is made up of red blood cells." ;
rdfs:subClassOf obo:CMO_0001356 .
obo:SCDO_0000321 a rdfs:Class ;
rdfs:label "D57.219 Sickle-cell/Hb-C disease with crisis, unspecified" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000318 .
obo:SCDO_0000504 a rdfs:Class ;
rdfs:label "Hematology Analyzer" ;
rdfs:comment "A measurement device used to perform complete blood counts, erythrocyte sedimentation rates (ESRs), or coagulation tests." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_1000580 a rdfs:Class ;
rdfs:label "Hemoglobin Electrophoresis" ;
rdfs:comment "A blood test that uses the principles of gel electrophoresis to separate out the various types of hemoglobin in order to determine the level of different types of hemoglobin in the blood." ;
rdfs:subClassOf obo:SCDO_0000424 , obo:SCDO_0000522 , obo:SCDO_1000577 .
obo:NCIT_C74954 a rdfs:Class ;
rdfs:label "Liver Function Test" ;
rdfs:comment "The quantitative measurement of liver enzymes in the blood, which is useful in assessing the functional state of a patient's liver. Liver function tests include the measurement of albumin, alanine transaminase, aspartate transaminase, alkaline phosphatase, bilirubin, and gamma glutamyl transferase." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:NCIT_C83031 a rdfs:Class ;
rdfs:label "Visit Date" ;
rdfs:comment "The date on which a visit occurred." ;
rdfs:subClassOf obo:EUPATH_0000310 , obo:SCDO_1000537 .
obo:SCDO_0000618 a rdfs:Class ;
rdfs:label "Immunosuppressant Drug Level Decreased AE" ;
rdfs:comment "A drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:SCDO_0000115 a rdfs:Class ;
rdfs:label "Beta Zero Thalassemia" ;
rdfs:comment "Beta-zero thalassemia is a form of beta-thalassemia in which beta-globin chain synthesis is absent. The clinical phenotype is often that of transfusion-dependant beta thalassemia major, however modifying factors may ameliorate the symptoms of severe anemia (Cao & Gallanelo, 2010)." ;
rdfs:subClassOf obo:SCDO_0000111 .
obo:SCDO_1000113 a rdfs:Class ;
rdfs:label "HBB, GLU22VAL" ;
rdfs:comment "A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine." ;
rdfs:subClassOf obo:SCDO_0002305 .
obo:HP_0020063 a rdfs:Class ;
rdfs:label "Increased Hemoglobin Concentration" ;
rdfs:comment "An abnormal elevation above normal hemoglobin concentration in the circulation." ;
rdfs:subClassOf obo:HP_0020061 .
obo:HP_0001943 a rdfs:Class ;
rdfs:label "Hypoglycemia" ;
rdfs:comment "A decreased concentration of glucose in the blood." ;
rdfs:subClassOf obo:HP_0011014 .
obo:SCDO_0000246 a rdfs:Class ;
rdfs:label "Clinical Competence" ;
rdfs:comment "The capability to perform acceptably those duties directly related to patient care." ;
rdfs:subClassOf obo:SCDO_0000948 .
obo:SCDO_0001056 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-S Beta Minus Thalassemia" ;
rdfs:comment "A mild form of sickle cell thalassemia characterized by the presence of hemoglobin S and a reduced amount of hemoglobin A in the red blood cells. It is characterized by the presence of small red blood cells and mild anemia." ;
rdfs:subClassOf obo:NCIT_C95539 .
obo:SCDO_0001023 a rdfs:Class ;
rdfs:label "SCD Related Pain" ;
rdfs:comment "Pain resulting from the presence of Sickle Cell Disease (SCD). Such pain can be acute, chronic or a mixture of the two." ;
rdfs:subClassOf obo:SCDO_0000851 , obo:SCDO_0000895 , obo:SCDO_0000954 .
obo:HP_0003765 a rdfs:Class ;
rdfs:label "Psoriasis" ;
rdfs:comment "A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales)." ;
rdfs:subClassOf obo:HP_0011122 .
obo:NCIT_C15709 a rdfs:Class ;
rdfs:label "Genetic Testing" ;
rdfs:comment "The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder." ;
rdfs:subClassOf obo:SCDO_0000448 .
obo:HP_0002653 a rdfs:Class ;
rdfs:label "Bone Pain" ;
rdfs:comment "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone." ;
rdfs:subClassOf obo:SCDO_0000851 .
obo:SCDO_0000607 a rdfs:Class ;
rdfs:label "ICD-10-CM Diagnosis Codes" ;
rdfs:comment "The ICD-10-CM diagnosis classification system developed by the Centers for Disease Control and Prevention for use in all U.S. health care treatment settings. Diagnosis coding under this system uses a different number of digits and some other changes, but the format is very much the same as ICD-9-CM. The National Center for Health Statistics (NCHS), the Federal agency responsible for use of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10) in the United States, has developed a clinical modification of the classification for morbidity purposes. The ICD-10 is used to code and classify mortality data from death certificates, having replaced ICD-9 for this purpose as of January 1, 1999. ICD-10-CM is the replacement for ICD-9-CM, volumes 1 and 2, effective October 1, 2015." ;
rdfs:subClassOf obo:SCDO_0000245 .
obo:VO_0000642 a rdfs:Class ;
rdfs:label "Influenza Virus Vaccine" ;
rdfs:comment "A viral vaccine that protects against infection with influenza virus." ;
rdfs:subClassOf obo:VO_0000001 .
obo:SCDO_0000522 a rdfs:Class ;
rdfs:label "Hemoglobin Variant Test" ;
rdfs:comment "A test to measure the presence and amount of a variant of hemoglobin in the blood." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_1000424 a rdfs:Class ;
rdfs:label "Study Policy" ;
rdfs:comment "A course or principle of action adopted or proposed by a study." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0001377 a rdfs:Class ;
rdfs:label "deprecated beta S mutation" ;
rdfs:comment "'To be defined by an expert [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0001081 a rdfs:Class ;
rdfs:label "Cholelithiasis" ;
rdfs:comment "Hard, pebble-like deposits that form within the gallbladder." ;
rdfs:subClassOf obo:HP_0025031 .
obo:HP_0001574 a rdfs:Class ;
rdfs:label "Abnormality of the Integument" ;
rdfs:comment "An abnormality of the integument, which consists of the skin and the superficial fascia." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_1000046 a rdfs:Class ;
rdfs:label "HBB, THR87ILE" ;
rdfs:comment "A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. This mutation is found as a single alteration in Hemoglobin Quebec-Chori. Compound heterozygosity for Hb Quebec-chori and Hb S results in sickle cell disease." ;
rdfs:subClassOf obo:SCDO_0009786 .
obo:SCDO_1000257 a rdfs:Class ;
rdfs:label "Three Tips About Sickle Cell Disease Every Emergency Provider Needs to Know" ;
rdfs:comment "A factsheet that shares steps to improve care in emergency departments (ED) of hospitals and clinics for people with sickle cell disease (SCD). It was created to help improve healthcare in the ED for patients with SCD." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_0000155 a rdfs:Class ;
rdfs:label "deprecated-Bone Sclerosis" ;
rdfs:comment "An abnormal hardening or increased density of bone tissue." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:HP_0001395 a rdfs:Class ;
rdfs:label "Hepatic Fibrosis" ;
rdfs:comment "The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process." ;
rdfs:subClassOf obo:HP_0001392 .
obo:SCDO_1000533 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Consented By Question" ;
rdfs:comment "The Sickle in Africa core data element that records the name of the person who managed the process of consenting the respondent." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000249 a rdfs:Class ;
rdfs:label "obsolete Clinical Diagnostic Questionnaire" ;
rdfs:comment "'A quick and accurate way of assessing the patient health states using well defined set of questions and analyzed for an optimal clinical decision for the patient. [Curator team: Gaston K. Mazandu]'" ;
rdfs:subClassOf obo:SCDO_0000957 .
obo:CMO_0000015 a rdfs:Class ;
rdfs:label "Body Temperature" ;
rdfs:comment "The level of heat in an organism." ;
rdfs:subClassOf obo:SCDO_0000728 .
obo:NCIT_C16564 a rdfs:Class ;
rdfs:label "Ethnic Group" ;
rdfs:comment "A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease." ;
rdfs:subClassOf obo:SCDO_0001551 .
obo:SCDO_0001218 a rdfs:Class ;
rdfs:label "obsolete Urology" ;
rdfs:comment "The medical specialty concerned with the study, diagnosis, and treatment of diseases of the genitourinary tract." ;
rdfs:subClassOf obo:SCDO_0001208 .
obo:SCDO_0000964 a rdfs:Class ;
rdfs:label "Radionuclide Imaging" ;
rdfs:comment "The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph." ;
rdfs:subClassOf obo:OBI_0000185 .
obo:HP_0000763 a rdfs:Class ;
rdfs:label "Sensory Neuropathy" ;
rdfs:comment "Peripheral neuropathy affecting the sensory nerves." ;
rdfs:subClassOf obo:HP_0009830 .
obo:SCDO_1000754 a rdfs:Class ;
rdfs:label "Body Temperature - Tympanic Measurement Assay" ;
rdfs:comment "An assay to determine the body temperature of an evaluant using a tympanic (i.e. ear) thermometer." ;
rdfs:subClassOf obo:OBI_0002140 .
obo:SCDO_0001229 a rdfs:Class ;
rdfs:label "Vaso-Occlusive Crisis" ;
rdfs:comment "Pain resulting from tissue ischemia as a result of blockage of blood vessels, occurring in a variety of vascular beds, but most commonly in the bone or bone marrow and requiring analgesic medication." ;
rdfs:subClassOf obo:SCDO_0001023 .
obo:SCDO_1000769 a rdfs:Class ;
rdfs:label "Basique" ;
rdfs:comment "Waiting for description for this." ;
rdfs:subClassOf obo:SCDO_1000577 .
obo:MP_0009568 a rdfs:Class ;
rdfs:label "Abnormal Red Blood Cell Deformability" ;
rdfs:comment "A measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress." ;
rdfs:subClassOf obo:HP_0020054 .
obo:UO_0000200 a rdfs:Class ;
rdfs:label "Cell Concentration Unit" ;
rdfs:comment "A concentration unit which denotes the average cell number in a given volume." ;
rdfs:subClassOf obo:UO_0000051 .
obo:SCDO_0000928 a rdfs:Class ;
rdfs:label "PROMIS Pediatric Profile 25" ;
rdfs:comment "This protocol includes 25 quality of life-type questions relating to physical function mobility, anxiety, depressive symptoms, fatigue, peer relationships, pain interference, and pain intensity over the past 7 days." ;
rdfs:subClassOf obo:NCIT_C102988 .
obo:SCDO_0000018 a rdfs:Class ;
rdfs:label "Acute Non-Specific Wheezing Episode" ;
rdfs:comment "An acute onset of wheezing in a person with SCD who has no co-morbid asthma." ;
rdfs:subClassOf obo:HP_0002086 , obo:SCDO_1000000 .
obo:SCDO_1000870 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Region Question" ;
rdfs:comment "The Sickle in Africa core data element that records the region in which the respondent lives." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0001715 a rdfs:Class ;
rdfs:label "deprecated-Neuropathic Pain" ;
rdfs:comment "Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0000195 a rdfs:Class ;
rdfs:label "Causal Adverse Drug Event Due to SNP" ;
rdfs:comment "A causal adverse drug event due to genetic predisposition that is specifically induced by SNP." ;
rdfs:subClassOf obo:SCDO_0000194 .
obo:DUO_0000028 a rdfs:Class ;
rdfs:label "Institution Specific Restriction" ;
rdfs:comment "This requirement indicates that use is limited to use within an approved institution." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_0000271 a rdfs:Class ;
rdfs:label "Complementary Therapy" ;
rdfs:comment "Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (physical therapy modalities; diet; acupuncture) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment. Year introduced: 2002(1986)." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:SCDO_0000873 a rdfs:Class ;
rdfs:label "Pediatric Migraine Disability Assessment" ;
rdfs:comment "A headache disability questionnaire which is completed by the patient and his/her parent and is reviewed with the clinician or study staff. It captures the impact of headaches on school performance (three questions), activities at home (one question on homework or chores), and social and/or sports functions (two questions). It is scored by summing the answers across the six questions. If a range is provided as an answer, either use the high end of the range or prompt for a single answer. The frequency and severity are not scored but can be used for clinical reference." ;
rdfs:subClassOf obo:SCDO_0000760 .
obo:SCDO_1000591 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hydroxyurea Use Question" ;
rdfs:comment "The Sickle in Africa core data element that records the respondent's hydroxyurea use status (i.e. an indication of whether the respondent is using hydroxyurea)." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:CMO_0000290 a rdfs:Class ;
rdfs:label "Mean Corpuscular Hemoglobin Level" ;
rdfs:comment "The average amount of hemoglobin per red blood cell calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood." ;
rdfs:subClassOf obo:CMO_0001356 .
obo:SCDO_0000332 a rdfs:Class ;
rdfs:label "D57.811 Other sickle-cell disorders with acute chest syndrome" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000331 .
obo:SCDO_0000037 a rdfs:Class ;
rdfs:label "Albuminuria" ;
rdfs:comment "Increased concentration of albumin in the urine; more than 30mg in 24hours or urine albumin creatinine ratio (ACR) >3 mg/mmol." ;
rdfs:subClassOf obo:SCDO_0000932 .
obo:NCIT_C101217 a rdfs:Class ;
rdfs:label "Retinal Examination" ;
rdfs:comment "An examination of the retina of the eye using an ophthalmoscope." ;
rdfs:subClassOf obo:SCDO_0000835 .
obo:SCDO_0000492 a rdfs:Class ;
rdfs:label "Health Records" ;
rdfs:comment "Health data accessible to the patient and others." ;
rdfs:subClassOf obo:SCDO_0000738 .
obo:SCDO_0001082 a rdfs:Class ;
rdfs:label "Social Environment" ;
rdfs:comment "The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community." ;
rdfs:subClassOf obo:SCDO_0000435 .
obo:SCDO_0000098 a rdfs:Class ;
rdfs:label "Bacteria" ;
rdfs:comment "One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to oxygen: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or phototrophy (via light reaction); for chemotrophs by their source of chemical energy: chemolithotrophy (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for carbon; nitrogen; etc.; heterotrophy (from organic sources) or autotrophy (from carbon dioxide). They can also be classified by whether or not they stain (based on the structure of their cell walls) with crystal violet dye: gram-negative or gram-positive." ;
rdfs:subClassOf obo:OBI_0000925 .
obo:EUPATH_0000215 a rdfs:Class ;
rdfs:label "Severe Anemia" ;
rdfs:comment "An anemia with hemoglobin levels less than 5 gm/dL." ;
rdfs:subClassOf obo:HP_0001903 .
obo:NCIT_C29719 a rdfs:Class ;
rdfs:label "Smoking History" ;
rdfs:comment "A record of an individual's background in regard to smoking tobacco. This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others." ;
rdfs:subClassOf obo:SCDO_0001120 .
obo:SCDO_0000206 a rdfs:Class ;
rdfs:label "Cerebral Collateral Flow" ;
rdfs:comment "Cerebral collateral circulation is a subsidiary vascular network which is dynamically recruited after arterial occlusion and may provide residual blood flow to ischemic areas." ;
rdfs:subClassOf obo:SCDO_0000213 .
obo:SCDO_0000540 a rdfs:Class ;
rdfs:label "deprecated Hemoglobin Lepore-Beta Thalassaemia" ;
rdfs:comment "'A form of beta-thalassemia in which the patient is compound heterozygous for hemoglobin lepore and beta-thalassemia, which results in beta-thalassemia intermedia to beta-thalassemia major. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000272 .
obo:ICO_0000179 a rdfs:Class ;
rdfs:label "Broad Consent" ;
rdfs:comment "An informed consent for an unspecified range of future research subject to a few content and/or process restrictions." ;
rdfs:subClassOf obo:SCDO_0007087 .
obo:HP_0002870 a rdfs:Class ;
rdfs:label "Obstructive Sleep Apnea" ;
rdfs:comment "A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow." ;
rdfs:subClassOf obo:HP_0000708 .
obo:SCDO_0001334 a rdfs:Class ;
rdfs:label "Chronic Phenotype" ;
rdfs:comment "An observable characteristic of disease that is persistent and long standing." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0000567 a rdfs:Class ;
rdfs:label "History of Kidney Failure Diagnostic Instrument" ;
rdfs:comment "A questionnaire to determine if the respondent has a history of kidney failure." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_1000330 a rdfs:Class ;
rdfs:label "Epilepsy Screener - Adult" ;
rdfs:comment "A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in adults." ;
rdfs:subClassOf obo:SCDO_0000440 .
obo:SCDO_0009884 a rdfs:Class ;
rdfs:label "Biochemical Phenotype" ;
rdfs:comment "The proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." ;
rdfs:subClassOf obo:SCDO_0007623 .
obo:SCDO_1000061 a rdfs:Class ;
rdfs:label "Altered Level of Normal Hemoglobin in SCD" ;
rdfs:comment "An altered level of normal hemoglobin (Hemoglobin A (Hb A), Hemoglobin A2 (Hb A2) or Hemoglobin F (Hb F, fetal hemoglobin) in the blood, which may be seen in those suffering with Sickle Cell Disease (SCD)." ;
rdfs:subClassOf obo:SCDO_1000276 .
obo:SCDO_1000103 a rdfs:Class ;
rdfs:label "Genetic Locus" ;
rdfs:comment "A specific region that is mapped within a genome. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or hereditary disease." ;
rdfs:subClassOf obo:SCDO_0005722 .
obo:UO_0000186 a rdfs:Class ;
rdfs:label "Dimensionless Unit" ;
rdfs:comment "A unit which is a standard measure of physical quantity consisting of only a numerical number without any units." ;
rdfs:subClassOf obo:UO_0000000 .
obo:HP_0000618 a rdfs:Class ;
rdfs:label "Blindness" ;
rdfs:comment "Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degress in radius around central fixation." ;
rdfs:subClassOf obo:HP_0000505 .
obo:NCIT_C25191 a rdfs:Class ;
rdfs:label "Person Name" ;
rdfs:comment "A word or group of words indicating the identity of a person usually consisting of a first (personal) name and a last (family) name with an optional middle name. In some cultural traditions the family name comes first." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_1000599 a rdfs:Class ;
rdfs:label "Malaria Prophylaxis Status" ;
rdfs:comment "An indication of whether the respondent is using malaria prophylaxis." ;
rdfs:subClassOf obo:SCDO_1000318 , obo:SCDO_1000590 .
obo:SCDO_1000689 a rdfs:Class ;
rdfs:label "Hemoglobin G-Philadelphia" ;
rdfs:comment "Hemoglobin G Philadelphia (HbG Phil) is a structural variant of the hemoglobin molecule that involves the alpha chain rather than the beta chain. It has a frequency of about 1 in 5,000 African Americans, but has been reported in other ethnic groups in the Mediterranean region as well, HbG Phil itself has no clinical consequences. The only finding of clinical interest is the mild microcytosis. While this molecule has no clinical consequences, the presence helps to distinguish HbG from HbD that shares its electrophoretic migration on HPLC and gel electrophoresis and which does have consequences when it occurs with sickle trait." ;
rdfs:subClassOf obo:SCDO_0006921 .
obo:SCDO_0001077 a rdfs:Class ;
rdfs:label "Slit Lamp" ;
rdfs:comment "A microscope with a light source that can be projected into a linear beam. It allows cross-sectional viewing of the aqueous humor; conjuncteiva; cornea; eyelids; iris; and lens of the eye." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_1000662 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Alkaline Phosphatase Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the level of alkaline phosphatase in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:MP_0001762 a rdfs:Class ;
rdfs:label "Diuresis" ;
rdfs:comment "Increased volume of urine produced and excreted." ;
rdfs:subClassOf obo:HP_0000079 .
obo:SCDO_0009488 a rdfs:Class ;
rdfs:label "obsolete Molecule" ;
rdfs:comment "'Any single chemical entity that is an electrically neutral entity consisting of more than one atom. Each atom carries a certain number of electrons that orbit around the nucleus.[Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_0003675 a rdfs:Class ;
rdfs:label "Single Nucleotide Polymorphism" ;
rdfs:comment "A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population." ;
rdfs:subClassOf obo:NCIT_C17004 .
obo:SYMP_0000412 a rdfs:Class ;
rdfs:label "Anxiety" ;
rdfs:comment "A neurological and physiological symptom characterized by a painful or apprehensive uneasiness of mind usually over an impending or anticipated ill." ;
rdfs:subClassOf obo:HP_0000708 , obo:SCDO_0000746 , obo:SCDO_0000954 .
obo:SCDO_1000695 a rdfs:Class ;
rdfs:label "Hemoglobin C Level" ;
rdfs:comment "The amount of hemoglobin C present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:SCDO_0000616 a rdfs:Class ;
rdfs:label "Immunochemical Assay" ;
rdfs:comment "An assay that identifies a substance (especially a protein) by its action as an antigen." ;
rdfs:subClassOf obo:NCIT_C16723 .
obo:SCDO_0000796 a rdfs:Class ;
rdfs:label "Nephrotic Syndrome" ;
rdfs:comment "Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria >3.5 g per 24 hours (in children, >40 mg/m2/hr or PCR >2000 mg/g [>200 mg/mmol] or >300 mg/dl or 3+ on urine dipstick) plus hypoalbuminemia (<3gm/dl) and edema." ;
rdfs:subClassOf obo:HP_0000112 .
obo:SCDO_0000944 a rdfs:Class ;
rdfs:label "Pulse Oximeter" ;
rdfs:comment "A measurement device, usually attached to the earlobe or fingertip, that measures the oxygen saturation of arterial blood." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:NCIT_C71375 a rdfs:Class ;
rdfs:label "Abdominal Ultrasound" ;
rdfs:comment "A method of ultrasound imaging in which the ultrasound probe is pressed against the skin of the abdomen in order to create an image of the abdominal organs." ;
rdfs:subClassOf obo:NCIT_C17230 .
obo:SCDO_1000012 a rdfs:Class ;
rdfs:label "Beta-Globin Family Members" ;
rdfs:comment "Members of the beta-globin family. In humans, they are encoded in a gene cluster on chromosome 11. They include hemoglobin subunit epsilon, hemoglobin subunit gamma, hemoglobin subunit delta and hemoglobin subunit beta. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult hemoglobin is comprised of two alpha globin chains and two beta-globin chains." ;
rdfs:subClassOf obo:SCDO_0005339 , obo:SCDO_1000104 .
obo:SCDO_1000215 a rdfs:Class ;
rdfs:label "Structural and Quantitative Hemoglobinopathy" ;
rdfs:comment "A hemoglobinopathy involving the presence of structurally abnormal hemoglobins and defects in the quantity of hemoglobins synthesised." ;
rdfs:subClassOf obo:SCDO_0000552 .
obo:HP_0001701 a rdfs:Class ;
rdfs:label "Pericarditis" ;
rdfs:comment "Inflammation of the sac-like covering around the heart (pericardium)." ;
rdfs:subClassOf obo:HP_0011025 .
obo:SCDO_0000970 a rdfs:Class ;
rdfs:label "Recovery and Recurrence Questionnaire (RRQ)" ;
rdfs:comment "A questionnaire that assesses recovery and recurrence of stroke in children. It is completed by a parent about their child." ;
rdfs:subClassOf obo:SCDO_0001339 .
obo:SCDO_1000583 a rdfs:Class ;
rdfs:label "Blood Type A Negative" ;
rdfs:comment "SCDO (Kambe Banda)" ;
rdfs:subClassOf obo:HP_0032224 .
obo:HP_0002014 a rdfs:Class ;
rdfs:label "Diarrhea" ;
rdfs:comment "Abnormally increased frequency of loose or watery bowel movements." ;
rdfs:subClassOf obo:HP_0025031 .
obo:SCDO_0006000 a rdfs:Class ;
rdfs:label "Fever" ;
rdfs:comment "Elevated body temperature due to failed thermoregulation, or inflammation or immune responses." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_1000702 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Hemoglobin G-Philadelphia Level Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin G-Philadelphia." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000792 a rdfs:Class ;
rdfs:label "D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_1000791 .
obo:HP_0001025 a rdfs:Class ;
rdfs:label "Urticaria" ;
rdfs:comment "Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure." ;
rdfs:subClassOf obo:HP_0002597 .
obo:HP_0005518 a rdfs:Class ;
rdfs:label "Increased Mean Corpuscular Volume" ;
rdfs:comment "Larger than normal size of erythrocytes. Macrocytosis refers to a mean cell volume (MCV) greater than 100 fL. If macrocytosis is an isolated abnormality, the amount of hemoglobin in the cell increases proportionately, so the mean cell hemoglobin concentration (MCHC) remains within normal limits." ;
rdfs:subClassOf obo:HP_0025065 .
obo:SCDO_1000023 a rdfs:Class ;
rdfs:label "obsolete Evidence Code" ;
rdfs:comment "'Every annotation must be attributed to a source, which may be a literature reference, another database or a computational analysis. The annotation must indicate what kind of evidence is found in the cited source to support the association between the gene product and the GO term. A simple controlled vocabulary is used to record evidence; and the evidence codes are simply the three-letter codes used to signify the type of evidence cited. [Curator team: Exact []]'" ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:SCDO_1000366 a rdfs:Class ;
rdfs:label "Delta Beta Thalassemia Mutation" ;
rdfs:comment "A mutation that contributes to decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis." ;
rdfs:subClassOf obo:SCDO_0009731 .
obo:SCDO_0000583 a rdfs:Class ;
rdfs:label "Hydroxyurea-Induced Splenomegaly Adverse Event" ;
rdfs:comment "A hydroxyurea-induced adverse event that has the outcome of splenomegaly." ;
rdfs:subClassOf obo:SCDO_0000581 .
obo:SCDO_0001164 a rdfs:Class ;
rdfs:label "Traditional Healer" ;
rdfs:comment "A person who practices the art of healing using traditional medicine, a system of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (spiritual therapies); phytotherapy (plant therapy) and other treatments which may not be explained by modern medicine." ;
rdfs:subClassOf obo:SCDO_0000108 .
obo:SCDO_1000356 a rdfs:Class ;
rdfs:label "Altitude" ;
rdfs:comment "Height above sea level or above the earth's surface." ;
rdfs:subClassOf obo:SCDO_0000897 .
obo:SCDO_0001200 a rdfs:Class ;
rdfs:label "UGT1A1" ;
rdfs:comment "This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome." ;
rdfs:subClassOf obo:SCDO_0000810 .
obo:HP_0030243 a rdfs:Class ;
rdfs:label "Hepatic Vein Thrombosis" ;
rdfs:comment "An obstruction in the veins of the liver caused by a blood clot (thrombosis)." ;
rdfs:subClassOf obo:HP_0001977 .
obo:SCDO_0000564 a rdfs:Class ;
rdfs:label "Hip Replacement Arthroplasty" ;
rdfs:comment "Replacement of the hip joint." ;
rdfs:subClassOf obo:SCDO_0001129 , obo:SCDO_0001133 .
obo:SCDO_0000032 a rdfs:Class ;
rdfs:label "Agenesis of Corpus Callosum" ;
rdfs:comment "A rare congenital disorder characterized by a partial or complete absence (agenesis) of an area of the brain that connects the two cerebral hemispheres. It can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline." ;
rdfs:subClassOf obo:HP_0002060 .
obo:NCIT_C19228 a rdfs:Class ;
rdfs:label "Optical Instrument" ;
rdfs:comment "An instrument used to measure an event involving emission, absorption, or refraction of light." ;
rdfs:subClassOf obo:OBI_0400169 .
obo:SCDO_0000649 a rdfs:Class ;
rdfs:label "Intelligence Scale - Birth to 3.5 years" ;
rdfs:comment "A standardized tool designed to assess a child's development as compared to same-age peers. It has components that involve both direct observation and interaction with a child as well as caregiver questionnaires. It consists of five domains (cognitive, motor, language, social-emotional, and adaptive behavior)." ;
rdfs:subClassOf obo:NCIT_C122920 .
obo:VT_0000202 a rdfs:Class ;
rdfs:label "Alkaline Phosphatase Level" ;
rdfs:comment "The amount of alkaline phosphatase present in a specified volume of blood." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_1000775 a rdfs:Class ;
rdfs:label "D57.09 Hb-SS disease with crisis with other specified complication" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000312 .
obo:OBI_0000990 a rdfs:Class ;
rdfs:label "Electron Microscope" ;
rdfs:comment "A microscope that produces an image of an object by targeting it with an electron beam." ;
rdfs:subClassOf obo:OBI_0400169 .
obo:MP_0011470 a rdfs:Class ;
rdfs:label "Increased Urine Creatinine Level" ;
rdfs:comment "An increased amount of creatinine in the urine compared to the normal state." ;
rdfs:subClassOf obo:MP_0011469 .
obo:SCDO_1000475 a rdfs:Class ;
rdfs:label "Clinical or Research Assessment Question Type" ;
rdfs:comment "A type of question pertaining to a clinical or research assessment data element." ;
rdfs:subClassOf obo:SCDO_1000472 .
obo:SCDO_0000521 a rdfs:Class ;
rdfs:label "deprecated Hemoglobin C-Beta Thalassemia" ;
rdfs:comment "'A form of beta-thalassemia with a phenotype of mild to moderate hemolytic anemia. Patients are often asymptomatic but if present symptoms include anemia and enlarged spleen.'" ;
rdfs:subClassOf obo:SCDO_0000272 .
obo:SCDO_0000188 a rdfs:Class ;
rdfs:label "obsolete Case Reports" ;
rdfs:comment "'Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0000941 .
obo:SCDO_1000280 a rdfs:Class ;
rdfs:label "Transfusion Hemochromatosis" ;
rdfs:comment "Hemochromatosis that results from repeated blood transfusions." ;
rdfs:subClassOf obo:SCDO_1000281 .
obo:SCDO_1000221 a rdfs:Class ;
rdfs:label "Alpha Thalassemia Silent Genotype" ;
rdfs:comment "A genotype whereby one of the four alpha-globin genes is faulty, either as a result of a single nucleotide variant (SNP) or of a deletion." ;
rdfs:subClassOf obo:EUPATH_0000034 .
obo:SCDO_0009664 a rdfs:Class ;
rdfs:label "Abdominal Vaso-Occlusive Crisis" ;
rdfs:comment "Pain resulting from tissue ischemia as a result of blockage of mesenteric blood vessels." ;
rdfs:subClassOf obo:SCDO_0001229 .
obo:HP_0032180 a rdfs:Class ;
rdfs:label "Abnormal Circulating Metabolite Concentration" ;
rdfs:comment "An abnormal level of an analyte measured in the blood." ;
rdfs:subClassOf obo:MP_0009642 .
obo:CMO_0000003 a rdfs:Class ;
rdfs:label "Blood Pressure Measurement" ;
rdfs:comment "Measurement of the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood." ;
rdfs:subClassOf obo:CMO_0000001 .
obo:MP_0002118 a rdfs:Class ;
rdfs:label "Abnormal Lipid Homeostasis" ;
rdfs:comment "Anomaly in the processes involved in the maintenance of an internal equilibrium of lipids in the fluids and tissues." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_0000282 a rdfs:Class ;
rdfs:label "Controlled Pre-Post Studies" ;
rdfs:comment "A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:HP_0001787 a rdfs:Class ;
rdfs:label "Abnormal Delivery" ;
rdfs:comment "An abnormality of the birth process." ;
rdfs:subClassOf obo:HP_0001197 .
obo:SCDO_0000021 a rdfs:Class ;
rdfs:label "Acute Upper Respiratory Tract Infection" ;
rdfs:comment "An acute respiratory illness with no lower respiratory tract signs or infiiltrate on chest radiograph." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:HP_0012243 a rdfs:Class ;
rdfs:label "Abnormal Reproductive System Morphology" ;
rdfs:comment "A structural or developmental anomaly of any of the tissues involved in the genital system." ;
rdfs:subClassOf obo:HP_0000078 .
obo:SCDO_0000307 a rdfs:Class ;
rdfs:label "Current Marital Status" ;
rdfs:comment "The respondent's current marital status." ;
rdfs:subClassOf obo:NCIT_C16495 , obo:SCDO_0001090 , obo:SCDO_1000157 .
obo:SCDO_0000220 a rdfs:Class ;
rdfs:label "Children's Depression Inventory 2 (CDI 2)" ;
rdfs:comment "The CDI-2 is a 27-item self-report scale that helps to assess cognitive, affective and behavioral signs of depression in children and adolescents. Each item is scored on a scale from 0 to 2." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:HP_0025065 a rdfs:Class ;
rdfs:label "Abnormal Mean Corpuscular Volume" ;
rdfs:comment "A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters." ;
rdfs:subClassOf obo:HP_0001877 .
obo:SCDO_0000869 a rdfs:Class ;
rdfs:label "Patient Compliance" ;
rdfs:comment "Voluntary cooperation of the patient in following a prescribed regimen." ;
rdfs:subClassOf obo:SCDO_0000487 , obo:SCDO_0000746 .
obo:SCDO_1000114 a rdfs:Class ;
rdfs:label "HBB, THR87LYS" ;
rdfs:comment "A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine." ;
rdfs:subClassOf obo:SCDO_0002305 .
obo:NCIT_C84980 a rdfs:Class ;
rdfs:label "Hemoglobin Subunit Delta" ;
rdfs:comment "A type of polypeptide chain that when in combination with alpha globin polypeptide chains forms adult hemoglobin 2 (HbA2). HbA2 comprises around 3% of adult hemoglobin. Hemoglobin subunit delta (147 aa, ~16 kDa) is encoded by the human HBD gene. This protein plays a role in the transport of oxygen to tissues of the adult body." ;
rdfs:subClassOf obo:SCDO_1000012 .
obo:SCDO_0000108 a rdfs:Class ;
rdfs:label "Beliefs About Remedies and Treatment" ;
rdfs:comment "Personal or collective understanding of what can remedy or treat illness." ;
rdfs:subClassOf obo:SCDO_0000488 .
obo:SCDO_0001051 a rdfs:Class ;
rdfs:label "Variant Sickle Cell Syndrome" ;
rdfs:comment "A variant form of sickle cell disease that results from inheriting the sickle mutation in combination with another beta-globin gene mutation. These hemoglobinopathies may have different clinical severity compared to the homozygous form of sickle cell disease (HbSS)." ;
rdfs:subClassOf obo:SCDO_1000106 .
obo:HP_0001970 a rdfs:Class ;
rdfs:label "Interstitial Nephritis" ;
rdfs:comment "A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." ;
rdfs:subClassOf obo:HP_0000123 .
obo:SCDO_0000930 a rdfs:Class ;
rdfs:label "Infection Prophylaxis" ;
rdfs:comment "A planned process that has the objective to reduce the risk of acquiring one or more infections." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0000922 .
obo:SCDO_1000251 a rdfs:Class ;
rdfs:label "Increased Red Cell Osmotic Fragility" ;
rdfs:comment "An increase in red blood cell sensitivity to change in osmotic pressure. More specifically, the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to osmotic stress by being placed in a hypotonic solution." ;
rdfs:subClassOf obo:HP_0020054 .
a rdfs:Class .
obo:IDO_0000515 a rdfs:Class ;
rdfs:label "Microbiome" ;
rdfs:comment "An organism population whose members are particpating in non-parasitic symbiosis with a particular host." ;
rdfs:subClassOf obo:SCDO_0000122 .
obo:SCDO_0004860 a rdfs:Class ;
rdfs:label "deprecated-Amoxicillin" ;
rdfs:comment "'A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000035 .
obo:UO_0000002 a rdfs:Class ;
rdfs:label "Mass Unit" ;
rdfs:comment "A unit which is a standard measure of the amount of matter/energy of a physical object." ;
rdfs:subClassOf obo:UO_0000000 .
obo:SCDO_1000139 a rdfs:Class ;
rdfs:label "Turkana" ;
rdfs:comment "The Turkana tribe is a nomadic pastoralist people that inhabit the Turkana district in Kenya's Rift Valley Province. Turkana tribe is part of the Nilotic tribes and constitutes the second largest pastoralist community in Kenya after the Maasais. They speak the Turkana language, which is Nilotic and similar to the Maasai language." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:DUO_0000020 a rdfs:Class ;
rdfs:label "Collaboration Required" ;
rdfs:comment "This could be coupled with a string describing the primary study investigator(s)." ;
rdfs:subClassOf obo:SCDO_1000408 .
obo:SCDO_0000874 a rdfs:Class ;
rdfs:label "Pediatric NIH Stroke Scale (PedNIHSS)" ;
rdfs:comment "A physical assessment of the various symptoms associated with a stroke, consisting of eleven categories. The PedNIHSS was developed by a panel of pediatric and adult stroke experts and is a modification of the adult NIH stroke scale (NIHSS). Modifications were made to allow individuals age 18 or younger to be assessed and are identified in the PedNIHSS by bold italic text." ;
rdfs:subClassOf obo:SCDO_0001112 .
obo:SCDO_1000209 a rdfs:Class ;
rdfs:label "Crossover between delta (HBD) and beta globin (HBB) gene loci" ;
rdfs:comment "The homologous recombination event that occurs during meiosis and results in the delta beta globin fusion chains that replace hemoglobin subunit beta chains in the abnormal hemoglobin, Hemoglobin Lepore." ;
rdfs:subClassOf obo:SCDO_1000208 .
obo:HP_0012587 a rdfs:Class ;
rdfs:label "Macroscopic Hematuria" ;
rdfs:comment "Hematuria that is visible upon inspection of the urine." ;
rdfs:subClassOf obo:SCDO_0000508 .
obo:SCDO_0001325 a rdfs:Class ;
rdfs:label "Flow Cytometer" ;
rdfs:comment "An instrument which is used to count and sort microscopic particles suspended in a buffer. This instrument consists of a flow cell, at least one lamp or laser, a variable number of emission detectors or photomultipliers, a system that converts analog signals to digital, and a computer to run the system and collect and analyze the data output." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:SCDO_1000828 a rdfs:Class ;
rdfs:label "Normal Red Blood Cell Distribution Width" ;
rdfs:comment "When the range of variation of red blood cell (RBC) volume falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:SCDO_1000873 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Nearest Landmark Question" ;
rdfs:comment "The Sickle in Africa core data element that records the landmark that is nearest to where the participant lives." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_0000409 a rdfs:Class ;
rdfs:label "Echocardiogram" ;
rdfs:comment "A physiological assay that uses standard ultrasound techniques to take two-dimensional pictures of the cardiovascular system and can produce accurate assessment of the velocity of blood and cardiac tissue at any arbitrary point using pulsed or continuous wave Doppler ultrasound." ;
rdfs:subClassOf obo:NCIT_C17230 .
obo:SCDO_1000536 a rdfs:Class ;
rdfs:label "Consented By" ;
rdfs:comment "The name of the person who conducted consenting of the respondent." ;
rdfs:subClassOf obo:SCDO_0007597 .
obo:SCDO_1000268 a rdfs:Class ;
rdfs:label "Abnormality of the Musculature" ;
rdfs:comment "Abnormality originating in one or more muscles of the set of muscles in the body." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0001146 a rdfs:Class ;
rdfs:label "The Duke Religion Index (DUREL)" ;
rdfs:comment "The Duke Religion Index (DUREL) is a five item scale which measures religiosity in three areas: organizational religiosity (OR), non-organizational religiosity (NOR), and intrinsic religiosity. Two of the questions were derived from large epidemiologic studies and have been shown to have a strong predictive value for many health outcomes. OR has been related to less depression, more social support, better physical health, lower resource utilization, and lower mortality. NOR has been shown to be related to poorer physical health, and greater social support. The other three items were taken from the Hoge 10- item religiosity scale (Hodge et al 1972). The DUREL has high test-retest reliability (intra-class correlation = 0.91), high internal consistency (Cronbach's alpha's = 0.78--0.91)." ;
rdfs:subClassOf obo:SCDO_0000953 .
obo:NCIT_C123446 a rdfs:Class ;
rdfs:label "Continuous Ambulatory ECG" ;
rdfs:comment "A continuous electrocardiographic (ECG) recording that utilizes one or more leads that both records and stores data directly to a device worn by the subject, such that the subject need not be restricted to a medical facility, and may be able to participate in their customary activities of daily living." ;
rdfs:subClassOf obo:SCDO_0000500 .
obo:SCDO_0008595 a rdfs:Class ;
rdfs:label "Chronic Arthritis" ;
rdfs:comment "Persistence of an inflammatory event in the articulation overtime." ;
rdfs:subClassOf obo:HP_0001369 , obo:SCDO_0001334 .
obo:SCDO_1000569 a rdfs:Class ;
rdfs:label "Month of Diagnosis" ;
rdfs:comment "The month when a diagnosis was assigned to an individual's condition." ;
rdfs:subClassOf obo:SCDO_1000538 .
obo:SCDO_1000157 a rdfs:Class ;
rdfs:label "Quality of Life Related Personal Attribute" ;
rdfs:comment "The distinguishing qualities or prominent aspects of an individual person that have some relation with quality of life." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:HP_0011868 a rdfs:Class ;
rdfs:label "Sciatica" ;
rdfs:comment "Pain in the lower back and hip radiating in the distribution of the sciatic nerve." ;
rdfs:subClassOf obo:HP_0003418 .
obo:SCDO_1000496 a rdfs:Class ;
rdfs:label "Multiple Choice Single Selection Question" ;
rdfs:comment "A close-ended question that provides multiple answers for respondents to select from but allows for the selection of only one option." ;
rdfs:subClassOf obo:SCDO_1000492 .
obo:SCDO_1000322 a rdfs:Class ;
rdfs:label "Never Smoker" ;
rdfs:comment "A person who has never smoked a cigarette, not even one or two puffs." ;
rdfs:subClassOf obo:SCDO_0000235 .
obo:SCDO_0000885 a rdfs:Class ;
rdfs:label "Peripheral Oxygen Saturation" ;
rdfs:comment "An estimation of the oxygen saturation level usually measured with a pulse oximeter device." ;
rdfs:subClassOf obo:CMO_0001324 .
obo:SCDO_0005243 a rdfs:Class ;
rdfs:label "Comparative Genomic Hybridisation" ;
rdfs:comment "A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations." ;
rdfs:subClassOf obo:SCDO_0000448 .
obo:MP_0005561 a rdfs:Class ;
rdfs:label "Increased Mean Corpuscular Hemoglobin" ;
rdfs:comment "Greater than the average levels of hemoglobin contained in an erythrocyte." ;
rdfs:subClassOf obo:MP_0001589 .
obo:SCDO_1000638 a rdfs:Class ;
rdfs:label "Red Blood Cell Distribution Width" ;
rdfs:comment "Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. Usually red blood cells are a standard size of about 6-8 μm in diameter. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.[1] If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia. It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause." ;
rdfs:subClassOf obo:CMO_0001356 .
obo:SCDO_0001303 a rdfs:Class ;
rdfs:label "Exchange Transfusion, Whole Blood" ;
rdfs:comment "Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria." ;
rdfs:subClassOf obo:SCDO_0000147 .
obo:CHEBI_23888 a rdfs:Class ;
rdfs:label "Drug" ;
rdfs:comment "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." ;
rdfs:subClassOf obo:SCDO_0001152 .
obo:SCDO_1000341 a rdfs:Class ;
rdfs:label "History of Kidney Failure" ;
rdfs:comment "A record of an individual's history of kidney failure." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:SCDO_1000017 a rdfs:Class ;
rdfs:label "Surgery" ;
rdfs:comment "A material processing technique that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury or to help improve bodily function or appearance." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:ENVO_02500036 a rdfs:Class ;
rdfs:label "Pollution" ;
rdfs:comment "An environmental system process that results in the introduction of contaminants into an environment." ;
rdfs:subClassOf obo:SCDO_0000897 .
obo:SCDO_0000194 a rdfs:Class ;
rdfs:label "Causal Adverse Drug Event Due to Genetic Predisposition" ;
rdfs:comment "A causal adverse drug event that is induced by genetic predisposition." ;
rdfs:subClassOf obo:SCDO_0000191 .
obo:SCDO_0000346 a rdfs:Class ;
rdfs:label "Dengue Fever" ;
rdfs:comment "An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with Dengue Virus. It is self-limiting and characterized by fever, myalgia, headache, and rash. Severe Dengue is a more virulent form of dengue." ;
rdfs:subClassOf obo:NCIT_C3439 .
obo:HP_0001873 a rdfs:Class ;
rdfs:label "Thrombocytopenia" ;
rdfs:comment "A reduction in the number of circulating thrombocytes." ;
rdfs:subClassOf obo:HP_0011873 .
obo:NCIT_C17241 a rdfs:Class ;
rdfs:label "Urine Test" ;
rdfs:comment "Laboratory analysis of urine, commonly used to aid in the diagnosis of disease or to detect the presence of a specific substance. It involves examination of the urine by physical or chemical means as well as microscopic examination that helps to screen for urinary tract infections, renal disease, and diseases of other organs, that result in abnormal metabolites (break-down products) appearing in the urine." ;
rdfs:subClassOf obo:SCDO_0000902 .
obo:SCDO_1000109 a rdfs:Class ;
rdfs:label "HBB, GLU121GLN" ;
rdfs:comment "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine." ;
rdfs:subClassOf obo:SCDO_0002305 , obo:SCDO_0009786 .
obo:SCDO_1000590 a rdfs:Class ;
rdfs:label "SCD Management Details" ;
rdfs:comment "Information about how a patient's SCD is being managed." ;
rdfs:subClassOf obo:NCIT_C19332 , obo:SCDO_0001152 .
obo:HP_0002665 a rdfs:Class ;
rdfs:label "Lymphoma" ;
rdfs:comment "A cancer originating in lymphocytes and presenting as a solid tumor of lymphoid cells." ;
rdfs:subClassOf obo:OBI_1110053 .
obo:SCDO_1000485 a rdfs:Class ;
rdfs:label "deprecated File Upload Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:HP_0002149 a rdfs:Class ;
rdfs:label "Hyperuricemia" ;
rdfs:comment "An abnormally high level of uric acid in the blood." ;
rdfs:subClassOf obo:HP_0002157 .
obo:SCDO_0003712 a rdfs:Class ;
rdfs:label "Proxy Consent" ;
rdfs:comment "A legal representation or family member of the participant gives consent on behalf of the patient." ;
rdfs:subClassOf obo:NCIT_C25460 .
obo:SCDO_0000678 a rdfs:Class ;
rdfs:label "Knowledge about Sickle Cell Disease" ;
rdfs:comment "Collections of facts, assumptions, beliefs and practices that health professionals hold about the aetiology, pathophysiology, quality management of SCD and related social support systems based on global standards." ;
rdfs:subClassOf obo:SCDO_0000246 .
obo:HP_0000789 a rdfs:Class ;
rdfs:label "Infertility" ;
rdfs:comment "Inability to produce live offspring." ;
rdfs:subClassOf obo:HP_0000080 .
obo:SCDO_1000237 a rdfs:Class ;
rdfs:label "Hemoglobin C-Harlem Trait" ;
rdfs:comment "The inheritance of one normal HBB gene along with an abnormal HBB gene that contains two amino acid substitutions, namely Glu6Val (HbS) and Asp73Asn." ;
rdfs:subClassOf obo:NCIT_C95534 .
obo:SCDO_0000038 a rdfs:Class ;
rdfs:label "Alcohol - Lifetime Use" ;
rdfs:comment "An indication of whether the respondent has ever consumed any alcoholic beverage during his or her entire life." ;
rdfs:subClassOf obo:NCIT_C81229 , obo:SCDO_1000318 .
obo:NCIT_C51773 a rdfs:Class ;
rdfs:label "Married" ;
rdfs:comment "Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:NCIT_C49674 a rdfs:Class ;
rdfs:label "Breaths per Minute" ;
rdfs:comment "The number of breaths (inhalation and exhalation) taken per minute time." ;
rdfs:subClassOf obo:UO_0000280 .
obo:SCDO_0001090 a rdfs:Class ;
rdfs:label "Socioeconomic Factors" ;
rdfs:comment "Social and economic factors that characterize the individual or group within the social structure." ;
rdfs:subClassOf obo:SCDO_0001082 .
obo:SCDO_1000198 a rdfs:Class ;
rdfs:label "HIV Nucleic Acid Test" ;
rdfs:comment "A test to detect HIV in a person's blood." ;
rdfs:subClassOf obo:SCDO_0000571 .
obo:SCDO_0000119 a rdfs:Class ;
rdfs:label "Bilirubin Blood Test" ;
rdfs:comment "A bioassay to measure levels of bilirubin, a yellow substance found in bile produced when the liver breaks down old red blood cells." ;
rdfs:subClassOf obo:NCIT_C74954 , obo:SCDO_0000133 .
obo:SCDO_1000550 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - SCD Other Test Question" ;
rdfs:comment "The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent, in the case where the type of test was not listed as an answer option in a previous data element." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:ARO_0000054 a rdfs:Class ;
rdfs:label "Penicillin" ;
rdfs:comment "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." ;
rdfs:subClassOf obo:NCIT_C258 , obo:SCDO_0000922 .
obo:SCDO_1000097 a rdfs:Class ;
rdfs:label "Human Subject" ;
rdfs:comment "An homo sapiens that bears an experimental subject role which is realized through his/her participation in a scientific technique as the subject of interest (ie as the subject about which data is generated in an assay or study, or the entity that is transformed or modified in a material processing technique)." ;
rdfs:subClassOf obo:SCDO_0300005 .
obo:SCDO_0000566 a rdfs:Class ;
rdfs:label "History of Head Trauma Diagnostic Instrument" ;
rdfs:comment "A questionnaire to determine whether an individual has had a traumatic brain injury (TBI)." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_0000903 a rdfs:Class ;
rdfs:label "Physiotherapy" ;
rdfs:comment "A therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention." ;
rdfs:subClassOf obo:SCDO_0000978 .
obo:NCIT_C258 a rdfs:Class ;
rdfs:label "Antibiotic" ;
rdfs:comment "Substances naturally produced by microorganisms or their derivatives that selectively target microorganisms not humans. Antibiotics kill or inhibit the growth of microorganisms by targeting components of the microbial cell absent from human cells, including bacterial cell walls, cell membrane, and 30S or 50S ribosomal subunits. These substances are used in the treatment of bacterial and other microbial infections." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001133 .
obo:HP_0001287 a rdfs:Class ;
rdfs:label "Meningitis" ;
rdfs:comment "Inflammation of the meninges." ;
rdfs:subClassOf obo:HP_0002715 , obo:IDO_0000586 .
obo:NCIT_C62005 a rdfs:Class ;
rdfs:label "Amitriptyline" ;
rdfs:comment "A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001133 .
obo:NCIT_C39547 a rdfs:Class ;
rdfs:label "Treatment Efficacy" ;
rdfs:comment "The probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials." ;
rdfs:subClassOf obo:NCIT_C43646 .
obo:SCDO_1000862 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Last Name Question" ;
rdfs:comment "The Sickle in Africa core data element that records a respondent's last name." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000877 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Telephone 2 Question" ;
rdfs:comment "The Sickle in Africa core data element that records the participant's secondary telephone number." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:MP_0005535 a rdfs:Class ;
rdfs:label "Abnormal Body Temperature" ;
rdfs:comment "Deviation in the level of heat natural to a living being." ;
rdfs:subClassOf obo:SCDO_0002674 .
obo:SCDO_1000786 a rdfs:Class ;
rdfs:label "D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000318 .
obo:NCIT_C126121 a rdfs:Class ;
rdfs:label "Deoxygenated Hemoglobin" ;
rdfs:comment "Hemoglobin containing a heme group that is not bound to oxygen (O2). This molecule is normally found in the systemic veins following transit through capillaries and release of O2 into the tissues. Excess deoxyhemoglobin can be associated with hypoxia." ;
rdfs:subClassOf obo:NCIT_C16676 .
obo:SCDO_1000038 a rdfs:Class ;
rdfs:label "SCD Causal Mutation" ;
rdfs:comment "A mutation wholly or partly responsible for causing a sickle cell disease." ;
rdfs:subClassOf obo:IDOMAL_50000026 .
obo:SCDO_1000758 a rdfs:Class ;
rdfs:label "Axillary Temperature" ;
rdfs:comment "The temperature of the axillary fossa." ;
rdfs:subClassOf obo:CMO_0000015 .
obo:SCDO_0000199 a rdfs:Class ;
rdfs:label "Cell Free Hemoglobin Level" ;
rdfs:comment "The level of hemoglobin external to erythrocytes in a biological specimen." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:CMO_0000029 a rdfs:Class ;
rdfs:label "Platelet Count" ;
rdfs:comment "The number of platelets (thrombocytes) in a specified volume of blood, usually expressed as platelets per cubic millimeter of whole blood." ;
rdfs:subClassOf obo:CMO_0000921 .
obo:SCDO_0000746 a rdfs:Class ;
rdfs:label "Mental Health" ;
rdfs:comment "Emotional, psychological, and social well-being of an individual or group." ;
rdfs:subClassOf obo:NCIT_C17047 .
obo:SCDO_0001135 a rdfs:Class ;
rdfs:label "Acute Sickle Cell Crisis" ;
rdfs:comment "Refers to a worsening, over a short period of time, of the symptoms and signs of SCD; usually associated with pain and/or shortage of blood (anaemia). Can be suspected in a person with sickle cell disease who presents with a sudden onset of pain, infection, anemia or other symptoms such as stroke or priapism. Acute pain frequently occurs spontaneously, but may be precipitated by infections, skin cooling, dehydration or stress." ;
rdfs:subClassOf obo:SCDO_0000895 , obo:SCDO_1000000 .
obo:CMO_0000507 a rdfs:Class ;
rdfs:label "Hemoglobin Absorbance" ;
rdfs:comment "The optical density as calculated from the intensity of light at a specified wavelength as it passes through a solution of lysed red blood cells." ;
rdfs:subClassOf obo:CMO_0000508 .
obo:SCDO_1000226 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype AD" ;
rdfs:comment "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin D. Individuals with this genotype are known to be carriers of the hemoglobin D trait." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:CMO_0000211 a rdfs:Class ;
rdfs:label "Prothrombin Time" ;
rdfs:comment "Measurement of the clotting ability of fibrinogen, prothrombin, proaccelerin, proconvertin and Stuart factor, usually given in seconds to formation of clot after the addition of a tissue factor or thromboplastin." ;
rdfs:subClassOf obo:CMO_0000204 .
obo:NCIT_C17230 a rdfs:Class ;
rdfs:label "Ultrasound Test" ;
rdfs:comment "A technique in which high-frequency sound waves are bounced off internal organs and the echo pattern is converted into a 2 dimensional picture of the structures beneath the transducer." ;
rdfs:subClassOf obo:OBI_0000185 .
obo:SCDO_0002829 a rdfs:Class ;
rdfs:label "Sample" ;
rdfs:comment "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a material) to be used for testing, analysis, inspection, investigation, demonstration, or trial use." ;
rdfs:subClassOf obo:NCIT_C19332 .
obo:SCDO_1000797 a rdfs:Class ;
rdfs:label "D57.44 Sickle-cell thalassemia beta plus without crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000323 .
obo:CMO_0001324 a rdfs:Class ;
rdfs:label "Oxygen Saturation" ;
rdfs:comment "The amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity." ;
rdfs:subClassOf obo:CMO_0001321 .
obo:SCDO_1000836 a rdfs:Class ;
rdfs:label "Normal Urine Albumin Concentration" ;
rdfs:comment "When the concentration of urinary albumin falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:SCDO_1000855 a rdfs:Class ;
rdfs:label "Hospital Name" ;
rdfs:comment "The name of the hospital visited by a patient." ;
rdfs:subClassOf obo:EUPATH_0000310 .
obo:HP_0001298 a rdfs:Class ;
rdfs:label "Encephalopathy" ;
rdfs:comment "A term that means brain disease, damage, or malfunction. In general, it is manifested by an altered mental state." ;
rdfs:subClassOf obo:HP_0012638 .
obo:SCDO_0000318 a rdfs:Class ;
rdfs:label "D57.21 Sickle-cell/Hb-C disease with crisis" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000316 .
obo:SCDO_0001207 a rdfs:Class ;
rdfs:label "Urinary Protein Measurement" ;
rdfs:comment "Any measurement of protein present in urine." ;
rdfs:subClassOf obo:CMO_0000256 .
obo:SCDO_0000532 a rdfs:Class ;
rdfs:label "deprecated Hemoglobin E-Beta Thalassemia" ;
rdfs:comment "'Hemoglobin E/xcexb2+ thalassemia is a form of beta-thalassemia that is often, but not always, milder than hemoglobin E/xcexb2xc2xb0 thalassemia. This condition shows a marked clinically diverse picture whereby abnormalities of xcexb2-globin chain synthesis result almost asymptomatic anemia to more severe transfusion-dependant anemia (Vichinsky, 2007).'" ;
rdfs:subClassOf obo:SCDO_0000272 .
obo:SCDO_1000515 a rdfs:Class ;
rdfs:label "Specimen Storage Consent" ;
rdfs:comment "Voluntary authorization given by a study respondent and/or their proxy to have their specimen(s) stored." ;
rdfs:subClassOf obo:SCDO_0007087 .
obo:STATO_0000091 a rdfs:Class ;
rdfs:label "Genome Wide Association Study" ;
rdfs:comment "Genome wide association study is a kind of study whose objective is to detect association between genetic markers (SNP or otherwise) accross the genome and a trait which may be a disease or another phenotype (e.g. trait of agronomic relevance in animal or plant studies). Genome wide association study compare the allele frequencies in 2 populations, one free of the trait used as control, the other one showing the trait use as 'case'. GWAS studies implement case-control design." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_0006429 a rdfs:Class ;
rdfs:label "Gallbladder Empyema" ;
rdfs:comment "An uncommon complication of cholecystitis and refers to a situation where the gallbladder lumen is filled and distended by purulent material (pus)." ;
rdfs:subClassOf obo:HP_0025031 .
obo:SCDO_0000138 a rdfs:Class ;
rdfs:label "Blood Component Transfusion" ;
rdfs:comment "The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in plasmapheresis and types of cytapheresis; (plateletpheresis and leukapheresis) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor." ;
rdfs:subClassOf obo:SCDO_0000147 .
obo:SCDO_0000544 a rdfs:Class ;
rdfs:label "Hemoglobin O-Arab Disease" ;
rdfs:comment "A very rare autosomal recessive hemoglobinopathy characterized by an abnormal form of hemoglobin called hemoglobin O-Arab. It is associated with a mild to moderate anemia." ;
rdfs:subClassOf obo:SCDO_0008262 .
a rdfs:Class ;
rdfs:comment "An unconstrained type or object" .
obo:OPMI_0000023 a rdfs:Class ;
rdfs:label "Yes" ;
rdfs:comment "An answer to question where the answer is Yes." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:HP_0011001 a rdfs:Class ;
rdfs:label "Increased Bone Mineral Density" ;
rdfs:comment "An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often refered to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones." ;
rdfs:subClassOf obo:HP_0000924 .
obo:SCDO_1000079 a rdfs:Class ;
rdfs:label "deprecated Moderate S/Beta-Plus-Thal" ;
rdfs:comment "'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a moderate beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000091 .
obo:SCDO_0007597 a rdfs:Class ;
rdfs:label "Descriptor of Consent" ;
rdfs:comment "Information or a description of consent (hypothetical or obtained) or any aspect involved in or captured in the consent process." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:SCDO_1000028 a rdfs:Class ;
rdfs:label "obsolete TAS (traceable author statement)" ;
rdfs:comment "'Usually reviews or disease entries (e.g. OMIM) that only refers to the original publication. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:NCIT_C17047 a rdfs:Class ;
rdfs:label "Quality of Life" ;
rdfs:comment "The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness." ;
rdfs:subClassOf obo:SCDO_0000950 .
obo:SCDO_1000135 a rdfs:Class ;
rdfs:label "Taita/Taveta" ;
rdfs:comment "The Taita people are a Bantu tribe living in the Taita Hills on Kenya's southwest, near the Tanzania border and surrounding plains. Taita tribe actually consists of three separate but closely-related tribes: Wadawida (or Taita), Wasaghala (Sagalla) and Wataveta (Taveta)." ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:HP_0020059 a rdfs:Class ;
rdfs:label "Increased Red Blood Cell Count" ;
rdfs:comment "An abnormal elevation above the normal number of red blood cells per volume in the circulation." ;
rdfs:subClassOf obo:HP_0020058 .
obo:HP_0001635 a rdfs:Class ;
rdfs:label "Cardiac Failure" ;
rdfs:comment "The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction." ;
rdfs:subClassOf obo:HP_0011025 .
obo:NCIT_C116081 a rdfs:Class ;
rdfs:label "Dialysis Access Complication" ;
rdfs:comment "Any issue that arises as a consequence of a problem with a patient's dialysis access." ;
rdfs:subClassOf obo:NCIT_C2959 .
obo:HP_0100820 a rdfs:Class ;
rdfs:label "Glomerulopathy" ;
rdfs:comment "Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_0001121 a rdfs:Class ;
rdfs:label "Substances - Lifetime Use" ;
rdfs:comment "An indication of whether the respondent has ever used a drug during his or her entire life." ;
rdfs:subClassOf obo:SCDO_0001120 , obo:SCDO_1000318 .
obo:SCDO_1000479 a rdfs:Class ;
rdfs:label "deprecated Calculation Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:SCDO_1000339 a rdfs:Class ;
rdfs:label "History of Head Trauma" ;
rdfs:comment "A record of an individual's background in regard to head trauma." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:SCDO_1000243 a rdfs:Class ;
rdfs:label "Autosomal Recessive Compound Heterozygous" ;
rdfs:comment "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." ;
rdfs:subClassOf obo:HP_0000007 .
obo:HP_0025548 a rdfs:Class ;
rdfs:label "Increased Mean Corpuscular Hemoglobin Concentration" ;
rdfs:comment "Greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." ;
rdfs:subClassOf obo:HP_0025546 .
obo:SCDO_1000866 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Weight Question" ;
rdfs:comment "The Sickle in Africa core data element that records a respondent's measured weight." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000825 a rdfs:Class ;
rdfs:label "Normal Mean Corpuscular Volume" ;
rdfs:comment "When the average volume or size of a single red blood cell falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000821 .
obo:HP_0002019 a rdfs:Class ;
rdfs:label "Constipation" ;
rdfs:comment "Infrequent or difficult evacuation of feces." ;
rdfs:subClassOf obo:HP_0025031 .
obo:SCDO_0004598 a rdfs:Class ;
rdfs:label "Anticodon" ;
rdfs:comment "The sequential set of three nucleotides in transfer RNA that interacts with its complement in messenger RNA, the Codon, during translation in the ribosome." ;
rdfs:subClassOf obo:SCDO_0005593 .
obo:SCDO_0000049 a rdfs:Class ;
rdfs:label "Analgesia" ;
rdfs:comment "Methods of pain relief that may be used with or in place of analgesics." ;
rdfs:subClassOf obo:SCDO_0001133 .
obo:SCDO_1000027 a rdfs:Class ;
rdfs:label "obsolete ITM (inferred by text-mining)" ;
rdfs:comment "'Not described [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000023 .
obo:HP_0001626 a rdfs:Class ;
rdfs:label "Abnormality of Cardiovascular System" ;
rdfs:comment "Any abnormality of the cardiovascular system." ;
rdfs:subClassOf obo:HP_0000118 .
obo:HP_0002090 a rdfs:Class ;
rdfs:label "Pneumonia" ;
rdfs:comment "Inflammation of any part of the lung parenchyma." ;
rdfs:subClassOf obo:HP_0002086 , obo:HP_0002715 .
obo:HP_0001197 a rdfs:Class ;
rdfs:label "Abnormality of Prenatal Development or Birth" ;
rdfs:comment "An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_0006833 a rdfs:Class ;
rdfs:label "Moyamoya Disease" ;
rdfs:comment "A rare intracranial arteriopathy involving progressive stenosis of the cerebral vasculature located at the base of the brain causing transient ischemic attacks or strokes." ;
rdfs:subClassOf obo:SCDO_0000267 .
obo:SCDO_1000039 a rdfs:Class ;
rdfs:label "HBB, GLU6VAL" ;
rdfs:comment "The glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine." ;
rdfs:subClassOf obo:SCDO_1000038 .
obo:SCDO_0001062 a rdfs:Class ;
rdfs:label "Sickle Cell Disease-SE" ;
rdfs:comment "A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin E mutations, which can cause mild hemolytic anemia." ;
rdfs:subClassOf obo:SCDO_0008262 , obo:SCDO_1000163 .
obo:CHEBI_42797 a rdfs:Class ;
rdfs:label "Gabapentin" ;
rdfs:comment "A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0000922 .
obo:HP_0012203 a rdfs:Class ;
rdfs:label "Onychomycosis" ;
rdfs:comment "A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split." ;
rdfs:subClassOf obo:NCIT_C3245 .
obo:SCDO_1000431 a rdfs:Class ;
rdfs:label "Intestinal Fatty-Acid Binding Protein" ;
rdfs:comment "A protein expressed in enterocytes of the small intestine and released into the systemic circulation when there is intestinal damage. This protein plays a role in binding to saturated long-chain fatty acids with a high affinity and to unsaturated long-chain fatty acids with less affinity." ;
rdfs:subClassOf obo:NCIT_C26548 .
obo:SCDO_0000925 a rdfs:Class ;
rdfs:label "Proguanil" ;
rdfs:comment "A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. Cycloguanil stops the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite." ;
rdfs:subClassOf obo:IDOMAL_0000122 .
obo:SCDO_1000146 a rdfs:Class ;
rdfs:label "Management of Sickle Cell Disease - The United Republic of Tanzania" ;
rdfs:comment "Guidelines for health care professionals for management of sickle cell disease in patients in the Tanzanian context." ;
rdfs:subClassOf obo:SCDO_1000143 .
obo:SCDO_1000839 a rdfs:Class ;
rdfs:label "Normal Partial Pressure of Carbon Dioxide" ;
rdfs:comment "When the pressure exerted by carbon dioxide dissolved in the blood falls in the normal range." ;
rdfs:subClassOf obo:SCDO_1000812 .
obo:MP_0010068 a rdfs:Class ;
rdfs:label "Decreased Red Blood Cell Distribution Width" ;
rdfs:comment "Lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism." ;
rdfs:subClassOf obo:MP_0010066 .
obo:SCDO_1000588 a rdfs:Class ;
rdfs:label "Blood Type AB Positive" ;
rdfs:comment "A blood type containing both type A and B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." ;
rdfs:subClassOf obo:HP_0032224 .
obo:SCDO_1000300 a rdfs:Class ;
rdfs:label "Hepatitis B Core Antibody Test" ;
rdfs:comment "The determination of the amount of Hepatitis B virus core antibody present in a sample." ;
rdfs:subClassOf obo:SCDO_1000302 .
obo:SCDO_0000691 a rdfs:Class ;
rdfs:label "Light Coagulation" ;
rdfs:comment "The coagulation of tissue by an intense beam of light, including laser (laser coagulation). In the eye it is used in the treatment of retinal detachments, retinal holes, aneurysms, hemorrhages, and malignant and benign neoplasms. (Dictionary of Visual Science, 3d ed)" ;
rdfs:subClassOf obo:SCDO_0000833 .
obo:NCIT_C91105 a rdfs:Class ;
rdfs:label "Clinical or Research Assessment Questionnaire" ;
rdfs:comment "An instrument consisting of a predetermined set of questions for a clinical or research assessment." ;
rdfs:subClassOf obo:SCDO_1000472 .
obo:SCDO_1000436 a rdfs:Class ;
rdfs:label "Hypoxia-Reperfusion Injury" ;
rdfs:comment "Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (reperfusion), including swelling; hemorrhage; necrosis; and damage from free radicals. The most common instance is myocardial reperfusion injury." ;
rdfs:subClassOf obo:NCIT_C3671 .
obo:SCDO_1000492 a rdfs:Class ;
rdfs:label "Close-Ended Question" ;
rdfs:comment "A question that provides the respondent with specific answer options to choose from." ;
rdfs:subClassOf obo:SCDO_1000475 .
obo:HsapDv_0000000 a rdfs:Class ;
rdfs:label "Human Life Cycle Stage" ;
rdfs:comment "A spatiotemporal region encompassing some part of the life cycle of an organism." ;
rdfs:subClassOf obo:NCIT_C43646 .
obo:SCDO_1000527 a rdfs:Class ;
rdfs:label "Calculated Current Age" ;
rdfs:comment "The current age of a patient, calculated using the current date and the patient's date of birth." ;
rdfs:subClassOf obo:SCDO_0000304 .
obo:CMO_0000023 a rdfs:Class ;
rdfs:label "Blood Chemistry Measurement" ;
rdfs:comment "A quantification of a parameter of the chemical composition of blood." ;
rdfs:subClassOf obo:CMO_0000035 .
obo:SCDO_1000068 a rdfs:Class ;
rdfs:label "deprecated Severe S/Beta-Plus-Thal" ;
rdfs:comment "'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a severe beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_1000091 .
obo:NCIT_C92853 a rdfs:Class ;
rdfs:label "Postpartum Hemorrhage" ;
rdfs:comment "Hemorrhage defined as a blood loss in excess of 500 mL after vaginal delivery or more than 1000 mL after a cesarean delivery." ;
rdfs:subClassOf obo:HP_0001197 , obo:HP_0001871 , obo:NCIT_C34941 .
obo:NCIT_C96391 a rdfs:Class ;
rdfs:label "Meningococcal Conjugate Vaccine MCV4" ;
rdfs:comment "A conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135." ;
rdfs:subClassOf obo:VO_0000001 .
obo:SCDO_0005379 a rdfs:Class ;
rdfs:label "Database" ;
rdfs:comment "Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means." ;
rdfs:subClassOf obo:SCDO_0300003 .
obo:SCDO_0000952 a rdfs:Class ;
rdfs:label "Quality of Life in Sickle Cell Disease Measure" ;
rdfs:comment "A questionnaire to assess the physical, emotional, and social impact of chronic conditions, such as sickle cell disease (SCD)." ;
rdfs:subClassOf obo:SCDO_0000953 , obo:SCDO_1000297 .
obo:HP_0000953 a rdfs:Class ;
rdfs:label "Cutaneous Hyperpigmentation" ;
rdfs:comment "A darkening of the skin related to an increase in melanin production and deposition." ;
rdfs:subClassOf obo:HP_0011121 .
obo:SCDO_0006589 a rdfs:Class ;
rdfs:label "Cordocentesis" ;
rdfs:comment "The collecting of fetal blood samples typically via endoscopic ultrasound guided fine needle aspiration from the umbilical vein, followed by examination of the blood to detect fetal abnormalities." ;
rdfs:subClassOf obo:SCDO_0000505 , obo:SCDO_0000919 .
obo:SCDO_0007623 a rdfs:Class ;
rdfs:label "Molecular Phenotype" ;
rdfs:comment "The molecular characteristics of a cell of tissue including expressed coding and non-coding RNAs, proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." ;
rdfs:subClassOf obo:OGMS_0000023 .
obo:SCDO_0001340 a rdfs:Class ;
rdfs:label "deprecated Gastrointestinal System" ;
rdfs:comment "'The system concerned with the function and disorders of the gastrointestinal tract, including stomach, intestines, and associated organs including liver, pancreas and gall bladder. [Curator team: []]'" ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:HP_0001919 a rdfs:Class ;
rdfs:label "Acute Kidney Injury" ;
rdfs:comment "Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia)." ;
rdfs:subClassOf obo:HP_0000084 .
obo:ICO_0000278 a rdfs:Class ;
rdfs:label "Description of Future Biospecimen Use" ;
rdfs:comment "A descriptive information content entity that describes how biospecimens will be used." ;
rdfs:subClassOf obo:ICO_0000305 .
obo:SCDO_0002130 a rdfs:Class ;
rdfs:label "Transcriptome" ;
rdfs:comment "The pattern of gene expression at the level of genetic transcription in a specific organism or under specific circumstances in specific cells." ;
rdfs:subClassOf obo:SCDO_0005722 .
obo:HP_0001406 a rdfs:Class ;
rdfs:label "Intrahepatic Cholestasis" ;
rdfs:comment "Impairment of bile flow due to obstruction in the small bile ducts within the liver." ;
rdfs:subClassOf obo:HP_0001392 .
obo:SCDO_1000481 a rdfs:Class ;
rdfs:label "deprecated Descriptive Field Type" ;
rdfs:subClassOf obo:SCDO_1000477 .
obo:SCDO_1000464 a rdfs:Class ;
rdfs:label "Disapproval of Ethics" ;
rdfs:comment "When a research ethics committee declines a study's application for approval of their proposed research." ;
rdfs:subClassOf obo:SCDO_1000462 .
obo:SCDO_0000398 a rdfs:Class ;
rdfs:label "Drug Dependence AE" ;
rdfs:comment "An adverse drug event that results in the development of a dependence on the drug." ;
rdfs:subClassOf obo:SCDO_0000028 .
obo:VO_0000001 a rdfs:Class ;
rdfs:label "Vaccine" ;
rdfs:comment "A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine." ;
rdfs:subClassOf obo:SCDO_0000930 .
obo:ICO_0000228 a rdfs:Class ;
rdfs:label "Data Sharing" ;
rdfs:comment "A planned process in which data possessed by one person or organization is shared with one or more other persons or organizations." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:HP_0000112 a rdfs:Class ;
rdfs:label "Nephropathy" ;
rdfs:comment "A nonspecific term referring to disease or damage of the kidneys." ;
rdfs:subClassOf obo:HP_0000077 .
obo:SCDO_1000089 a rdfs:Class ;
rdfs:label "Hemoglobin Lepore Boston" ;
rdfs:comment "The most common Hemoglobin Lepore type and the only type of the three known variants described in association with HbS. This abnormal hemoglobin consists of two normal alpha globin chains (HBA) and two deltabeta globin fusion chains which occur due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis." ;
rdfs:subClassOf obo:SCDO_0000007 , obo:SCDO_0003807 .
obo:NCIT_C116161 a rdfs:Class ;
rdfs:label "Multiplex Ligation-Dependent Probe Amplification" ;
rdfs:comment "A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a single pair of PCR primers. It is frequently used in the detection of genetic aberrations in tumors, and can distinguish sequences differing in only a single nucleotide." ;
rdfs:subClassOf obo:SCDO_0000913 .
obo:CHEBI_6909 a rdfs:Class ;
rdfs:label "Metronidazole" ;
rdfs:comment "A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death." ;
rdfs:subClassOf obo:NCIT_C258 , obo:SCDO_0000922 .
obo:NCIT_C115224 a rdfs:Class ;
rdfs:label "Hepatic Complication" ;
rdfs:comment "Any disorder of the liver occurring as a consequence of injury to the liver parenchyma." ;
rdfs:subClassOf obo:NCIT_C2959 .
obo:SCDO_1000612 a rdfs:Class ;
rdfs:label "Abnormal Leukocyte Morphology" ;
rdfs:comment "Any structural abnormality of leukocytes (nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue)." ;
rdfs:subClassOf obo:HP_0001871 , obo:HP_0002715 .
obo:SCDO_0000553 a rdfs:Class ;
rdfs:label "obsolete Hemoglobinopathy Toms River" ;
rdfs:comment "Hemoglobinopathy Toms River, is also known as transient neonatal cyanosis and anemia due to toms river hemoglobin. An important gene associated with Hemoglobinopathy Toms River is HBG2 (Hemoglobin Subunit Gamma 2." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:HP_0000044 a rdfs:Class ;
rdfs:label "Hypogonadotropic Hypogonadism" ;
rdfs:comment "Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH)." ;
rdfs:subClassOf obo:HP_0000080 .
obo:SCDO_1000302 a rdfs:Class ;
rdfs:label "Hepatitis B Virus Antibody Test" ;
rdfs:comment "The determination of the amount of hepatitis B virus antibody present in a sample." ;
rdfs:subClassOf obo:SCDO_0000616 .
obo:SCDO_1000092 a rdfs:Class ;
rdfs:label "deprecated-Acute Severe Headache" ;
rdfs:comment "A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0004061 a rdfs:Class ;
rdfs:label "Genotype" ;
rdfs:comment "The genetic constitution of the individual, comprising the alleles present at each genetic locus." ;
rdfs:subClassOf obo:SCDO_0000765 .
obo:OBI_0400115 a rdfs:Class ;
rdfs:label "Spectrophotometer" ;
rdfs:comment "A spectrophotometer is an instrument that measures the intensity of light as a function of the color, or more specifically, the wavelength of light, transmitted by a substance." ;
rdfs:subClassOf obo:SCDO_0000376 .
obo:IDOMAL_0000122 a rdfs:Class ;
rdfs:label "Malaria Chemoprophylaxis" ;
rdfs:comment "The use of antimalarial drugs for the prevention of infection." ;
rdfs:subClassOf obo:SCDO_0000709 .
obo:ICO_0000293 a rdfs:Class ;
rdfs:label "Data Sharing Agreement" ;
rdfs:comment "A directive information entity that prescribes the information that is permitted to be shared or the processes for sharing that information." ;
rdfs:subClassOf obo:SCDO_1000406 .
obo:SCDO_1000345 a rdfs:Class ;
rdfs:label "Reproductive History Diagnostic Instrument - Female" ;
rdfs:comment "A questionnaire to assess females' pregnancy history." ;
rdfs:subClassOf obo:SCDO_0000987 .
obo:NCIT_C39796 a rdfs:Class ;
rdfs:label "Ethics" ;
rdfs:comment "The philosophical study of moral values and rules. Ethics is a general term for what is often described as the \"science of morality\". The Western tradition of ethics is sometimes called moral philosophy. This is one of the three major branches of philosophy, alongside metaphysics and logic." ;
rdfs:subClassOf obo:SCDO_0006339 .
obo:SCDO_0003028 a rdfs:Class ;
rdfs:label "Ethnic Status" ;
rdfs:comment "A person's ethnic status, whether conserved or mixed ethnicity." ;
rdfs:subClassOf obo:SCDO_0001551 .
obo:HP_0002829 a rdfs:Class ;
rdfs:label "Arthralgia" ;
rdfs:comment "Joint pain." ;
rdfs:subClassOf obo:SCDO_0000851 .
obo:SCDO_1000572 a rdfs:Class ;
rdfs:label "Diagnosis" ;
rdfs:comment "A diagnosis is the result of a medical investigation to identify a disorder from its signs and symptoms." ;
rdfs:subClassOf obo:NCIT_C18772 .
obo:SCDO_1000817 a rdfs:Class ;
rdfs:label "Absent Hemoglobin G-Philadelphia" ;
rdfs:comment "A lack of production of hemoglobin G-Philadelphia." ;
rdfs:subClassOf obo:SCDO_1000783 .
obo:SCDO_1000753 a rdfs:Class ;
rdfs:label "Body Temperature - Oral Measurement Assay" ;
rdfs:comment "An assay to determine the body temperature of an evaluant using an oral thermometer." ;
rdfs:subClassOf obo:OBI_0002140 .
obo:SCDO_0004277 a rdfs:Class ;
rdfs:label "Assent" ;
rdfs:comment "A term used to express willingness to participate in research by persons who are by definition too young to give informed consent but who are old enough to understand the proposed research in general, its expected risks and possible benefits, and the activities expected of them as subjects." ;
rdfs:subClassOf obo:SCDO_0007597 .
obo:SCDO_0000253 a rdfs:Class ;
rdfs:label "Clinical Studies as Topic" ;
rdfs:comment "Works about research studies that evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies." ;
rdfs:subClassOf obo:SCDO_0300004 .
obo:NCIT_C35146 a rdfs:Class ;
rdfs:label "Chronic Cholecystitis" ;
rdfs:comment "Cholecystitis that is persistent and long-standing." ;
rdfs:subClassOf obo:NCIT_C34465 , obo:SCDO_0001334 .
obo:NCIT_C92803 a rdfs:Class ;
rdfs:label "Genetic Screening" ;
rdfs:comment "Testing to determine if there is a predisposition or indication of a possible genetic or a chromosomal abnormality." ;
rdfs:subClassOf obo:NCIT_C15709 .
obo:SCDO_0000268 a rdfs:Class ;
rdfs:label "Comparative Study" ;
rdfs:comment "Comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs." ;
rdfs:subClassOf obo:SCDO_0000437 .
obo:SCDO_1000232 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype CC" ;
rdfs:comment "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 6 of beta-globin chains (hemoglobin C mutation) produced by both beta-globin gene (HBB) alleles." ;
rdfs:subClassOf obo:SCDO_0004061 .
obo:NCIT_C51776 a rdfs:Class ;
rdfs:label "Divorced" ;
rdfs:comment "Indicates a person whose marriage has been legally dissolved and has not remarried." ;
rdfs:subClassOf obo:NCIT_C91106 .
obo:SCDO_0001323 a rdfs:Class ;
rdfs:label "Serum Ferritin Level" ;
rdfs:comment "The amount of ferritin found in a specified volume of serum." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:SCDO_1000673 a rdfs:Class ;
rdfs:label "Current Partner Status" ;
rdfs:comment "An indication of a person's current status in terms of living with a person as though married (in a romantic relationship and living together but not married)." ;
rdfs:subClassOf obo:NCIT_C16495 .
obo:SCDO_1000120 a rdfs:Class ;
rdfs:label "Yoa" ;
rdfs:subClassOf obo:NCIT_C16564 .
obo:SCDO_0000985 a rdfs:Class ;
rdfs:label "Renal Transplant" ;
rdfs:comment "The transference of a kidney from one human or animal to another." ;
rdfs:subClassOf obo:SCDO_1000004 .
obo:CHMO_0002580 a rdfs:Class ;
rdfs:label "Colorimetric Test" ;
rdfs:comment "A test which produces colour change in the sample." ;
rdfs:subClassOf obo:SCDO_0000120 .
obo:SCDO_0000537 a rdfs:Class ;
rdfs:label "obsolete Hemoglobin Lepore Hollandia" ;
rdfs:comment "A variant of Hemoglobin Lepore Syndrome." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_0000080 a rdfs:Class ;
rdfs:label "Aspartate Aminotransferase Level" ;
rdfs:comment "The amount of aspartate aminotransferase present in a specified volume of blood." ;
rdfs:subClassOf obo:CMO_0000023 .
obo:NCIT_C50791 a rdfs:Class ;
rdfs:label "Urinary Tract Infection" ;
rdfs:comment "A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:SCDO_0001006 a rdfs:Class ;
rdfs:label "Reticulocyte Count by Microsocopy" ;
rdfs:comment "A reticulocyte count that was performed with microscopy." ;
rdfs:subClassOf obo:SCDO_0001004 .
obo:SCDO_0006911 a rdfs:Class ;
rdfs:label "Conserved Ethnicity" ;
rdfs:comment "An ethnic group that includes persons with ethnic contributions from only one ethnic group." ;
rdfs:subClassOf obo:SCDO_0003028 .
obo:SCDO_1000898 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Urea Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the concentration of urea in the respondent's blood." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000594 a rdfs:Class ;
rdfs:label "Date of Hydroxyurea Therapy Initiation" ;
rdfs:comment "The date on which hydroxyurea therapy was initiated." ;
rdfs:subClassOf obo:SCDO_1000537 .
obo:SCDO_0000510 a rdfs:Class ;
rdfs:label "HMOX1" ;
rdfs:comment "This gene encodes the enzyme, heme oxygenase 1, an essential enzyme in heme catabolism and cellular homeostasis." ;
rdfs:subClassOf obo:SCDO_0000810 .
obo:HP_0003198 a rdfs:Class ;
rdfs:label "Myopathy" ;
rdfs:comment "A disorder of muscle unrelated to impairment of innervation or neuromuscular junction." ;
rdfs:subClassOf obo:SCDO_1000268 .
obo:NCIT_C122920 a rdfs:Class ;
rdfs:label "Intelligence Scale" ;
rdfs:comment "An assessment tool designed to measure an individual's cognitive capabilities. It may be general or it may assess abilities in more discrete cognitive domains." ;
rdfs:subClassOf obo:NCIT_C91105 , obo:SCDO_1000033 .
obo:SCDO_1000352 a rdfs:Class ;
rdfs:label "Spirometry - Adult" ;
rdfs:comment "Measurement of the breathing capacity of an adult's lung by means of a spirometer." ;
rdfs:subClassOf obo:NCIT_C85397 .
obo:SCDO_0000689 a rdfs:Class ;
rdfs:label "Lifestyle" ;
rdfs:comment "Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)." ;
rdfs:subClassOf obo:SCDO_0000487 .
obo:SCDO_0000466 a rdfs:Class ;
rdfs:label "Haptoglobin Blood Test" ;
rdfs:comment "A bioassay to measure haptoglobin, which is produced by the liver and transports hemoglobin to the liver for recycling." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_1000888 a rdfs:Class ;
rdfs:label "Number of Units Transfused" ;
rdfs:comment "The number of units of blood that a patient received during a blood transfusion." ;
rdfs:subClassOf obo:SCDO_1000590 .
obo:HP_0000924 a rdfs:Class ;
rdfs:label "Abnormality of the Skeletal System" ;
rdfs:comment "An abnormality of the skeletal system." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_1000247 a rdfs:Class ;
rdfs:label "L-Glutamine Oral Powder" ;
rdfs:comment "A powder form of the optically active form of glutamine having L-configuration; to be administered orally." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001133 .
obo:SCDO_0001312 a rdfs:Class ;
rdfs:label "deprecated Eye" ;
rdfs:comment "The organ of vision that consists of the eyeball and the optic nerve." ;
rdfs:subClassOf obo:SCDO_0001336 .
obo:SCDO_1000034 a rdfs:Class ;
rdfs:label "from diagnostics" ;
rdfs:comment "Terms deprecated in the \"Diagnostics\" class." ;
rdfs:subClassOf obo:SCDO_0000359 .
obo:HP_0000099 a rdfs:Class ;
rdfs:label "Glomerulonephritis" ;
rdfs:comment "Inflammation of the renal glomeruli." ;
rdfs:subClassOf obo:HP_0000123 .
obo:GAZ_00000448 a rdfs:Class ;
rdfs:label "Geographic Location" ;
rdfs:comment "A reference to a place on the Earth, by its name or by its geographical location." ;
rdfs:subClassOf obo:SCDO_0000897 .
obo:NCIT_C124475 a rdfs:Class ;
rdfs:label "Mid Upper Arm Circumference" ;
rdfs:comment "A circumferential measurement of the largest part of the upper arm." ;
rdfs:subClassOf obo:CMO_0000021 .
obo:NCIT_C27222 a rdfs:Class ;
rdfs:label "Cerebral Aneurysm" ;
rdfs:comment "A balloon type pouch or bulge in the wall of a cerebral blood vessel." ;
rdfs:subClassOf obo:HP_0002060 .
obo:NCIT_C2890 a rdfs:Class ;
rdfs:label "Bacterial Infection" ;
rdfs:comment "An acute infectious disorder caused by gram positive or gram negative bacteria. Representative examples include pneumococcal, streptococcal, salmonella and meningeal infections." ;
rdfs:subClassOf obo:IDO_0000586 .
obo:SCDO_0000787 a rdfs:Class ;
rdfs:label "N-terminal Pro-brain Natriuretic Peptide Test" ;
rdfs:comment "A bioassay to determine an individual's level of N-terminal pro-brain natriuretic peptide (NT-proBNP)." ;
rdfs:subClassOf obo:SCDO_0000133 .
obo:SCDO_1000627 a rdfs:Class ;
rdfs:label "SickleInAfrica CDE - Mean Cell Hemoglobin Question" ;
rdfs:comment "The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin (MCH), as measured by a complete blood count." ;
rdfs:subClassOf obo:SCDO_1000509 .
obo:SCDO_1000692 a rdfs:Class ;
rdfs:label "Hemoglobin S Level" ;
rdfs:comment "The amount of hemoglobin S present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:NCIT_C113340 a rdfs:Class ;
rdfs:label "Secondary Amenorrhea" ;
rdfs:comment "The cessation of menstruation for six months or more in a female that is not pregnant, breastfeeding or menopausal." ;
rdfs:subClassOf obo:HP_0000080 .
obo:SCDO_0000050 a rdfs:Class ;
rdfs:label "Analgesic" ;
rdfs:comment "A compound capable of relieving pain without the loss of consciousness." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:SCDO_0001133 .
obo:SCDO_1000705 a rdfs:Class ;
rdfs:label "Hemoglobin O-Arab Level" ;
rdfs:comment "The amount of hemoglobin O-Arab present in a specified volume of blood." ;
rdfs:subClassOf obo:SCDO_0000546 .
obo:SCDO_1000049 a rdfs:Class ;
rdfs:label "Hemoglobin Genotype SC" ;
rdfs:comment "The genotype when an individual has the Hb C gene from one parent and the Hb S gene from the other. Individuals with Hb SC have similar symptoms to individuals with Hb SS, however, the anemia is less severe." ;
rdfs:subClassOf obo:SCDO_1000048 .
obo:SCDO_0000329 a rdfs:Class ;
rdfs:label "D57.8 Other sickle-cell disorders" ;
rdfs:comment "-" ;
rdfs:subClassOf obo:SCDO_0000311 .
obo:HP_0003563 a rdfs:Class ;
rdfs:label "Decreased Circulating LDL Cholesterol Level" ;
rdfs:comment "Reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions." ;
rdfs:subClassOf obo:HP_0003611 .
obo:SCDO_0000415 a rdfs:Class ;
rdfs:label "Electrocardiogram" ;
rdfs:comment "The visual output that an electrocardiograph produces." ;
rdfs:subClassOf obo:SCDO_1000313 .
obo:SCDO_0000702 a rdfs:Class ;
rdfs:label "Lot Quality Assurance Sampling" ;
rdfs:comment "A sampling methodology using small sample sizes when conducting surveys in small geographical or population-based areas or lots." ;
rdfs:subClassOf obo:SCDO_0300004 .
obo:SCDO_1000738 a rdfs:Class ;
rdfs:label "SickleInAfrica Core Data Element Instrument" ;
rdfs:comment "A data capture instrument designed and applied by the Sickle In Africa Consortium." ;
rdfs:subClassOf obo:NCIT_C91105 .
obo:SCDO_1000457 a rdfs:Class ;
rdfs:label "Temporal Consent Concept" ;
rdfs:comment "A type of consent that includes an aspect of timing (i.e. an indication of when consent was acquired)." ;
rdfs:subClassOf obo:NCIT_C25460 .
obo:SCDO_0000379 a rdfs:Class ;
rdfs:label "Diagnostics" ;
rdfs:comment "Diagnostic tools (including the instruments, laboratory assays and methods of patient examination) used for differential diagnosis, the measurements obtained using these tools, and the diagnostic devices used in obtaining the measurements." ;
rdfs:subClassOf obo:SCDO_0001000 .
obo:IAO_0000115 a rdf:Property ;
rdfs:label "definition" ;
rdfs:comment "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions." ;
rdfs:range xsd:string .
obo:IAO_0000412 a rdf:Property ;
rdfs:label "imported from" ;
rdfs:comment "For external terms/classes, the ontology from which the term was imported." ;
rdfs:range xsd:string .
obo:IAO_0100001 a rdf:Property ;
rdfs:label "term replaced by" ;
rdfs:comment "Use on obsolete terms, relating the term to another term that can be used as a substitute." ;
rdfs:range xsd:string .
obo:RO_0002200 a rdf:Property ;
rdfs:label "has phenotype" ;
rdfs:comment "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." ;
rdfs:range .
obo:RO_0002201 a rdf:Property ;
rdfs:label "phenotype of" ;
rdfs:comment "Inverse of \"has phenotype\" object property." ;
rdfs:range .
obo:RO_0002452 a rdf:Property ;
rdfs:label "has symptom" ;
rdfs:comment "A relation that holds between a disease or an organism and a phenotype that is a symptom (subjective evidence of disease perceived by the patient)." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002200 .
obo:RO_0003306 a rdf:Property ;
rdfs:label "contributes to frequency of condition" ;
rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000015 .
obo:RO_0003307 a rdf:Property ;
rdfs:label "ameliorates condition" ;
rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000015 .
obo:RO_0003309 a rdf:Property ;
rdfs:label "exacerbates condition" ;
rdfs:comment "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000015 .
obo:RO_0003310 a rdf:Property ;
rdfs:label "condition ameliorated by" ;
rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000005 .
obo:RO_0003311 a rdf:Property ;
rdfs:label "condition exacerbated by" ;
rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000005 .
obo:SCDO_0000031 a rdf:Property ;
rdfs:label "age of onset modified by" ;
rdfs:comment "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the age of onset of the phenotype. Age of onset is defined as \"The age group in which disease manifestations appear.\" (HPO)" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000005 .
obo:SCDO_0000303 a rdf:Property ;
rdfs:label "curator note" ;
rdfs:comment "An administrative note of use for a curator but of no use for a user." ;
rdfs:range xsd:string .
obo:SCDO_0000340 a rdf:Property ;
rdfs:label "definition source" ;
rdfs:comment "A source from where the formal description was derived. This can be in the form of a link to a relevant webpage, the IRI of a term in an existing ontology, a reference to specific literature, etc." ;
rdfs:range xsd:string .
obo:SCDO_0000363 a rdf:Property ;
rdfs:label "description adapted from source" ;
rdfs:comment "An assertion of whether or not the term/class description is an adaptation of the description in the description source." ;
rdfs:range .
obo:SCDO_0000468 a rdf:Property ;
rdfs:label "has age of onset" ;
rdfs:comment "A relation between a disease and the age, developmental stage, or period of life at which the disease or the initial symptoms or manifestations of the disease usually appear in individuals." ;
rdfs:range xsd:string .
obo:SCDO_0000470 a rdf:Property ;
rdfs:label "has cross-cultural adaptation" ;
rdfs:comment "A relation between a measure (e.g. a survey) and how the measure has been adapted cross-culturally." ;
rdfs:range xsd:string .
obo:SCDO_0000472 a rdf:Property ;
rdfs:label "has disease stage" ;
rdfs:comment "A relationship between a condition/disease and a description of how the condition/disease is staged/graded." ;
rdfs:range xsd:string .
obo:SCDO_0000475 a rdf:Property ;
rdfs:label "uses medical device" ;
rdfs:comment "A relation between a process (e.g. a form of therapy) and a medical device, where the medical device is used in the process." ;
rdfs:range .
obo:SCDO_0000479 a rdf:Property ;
rdfs:label "has protocol" ;
rdfs:comment "A relation between a measurement and a plan specification for obtaining the measurement that has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process." ;
rdfs:range xsd:string .
obo:SCDO_0000480 a rdf:Property ;
rdfs:label "has recommended procedure" ;
rdfs:comment "A relation between a measure or measurement and the recommended procedure used by the measure or used to obtain the measurement." ;
rdfs:range xsd:string .
obo:SCDO_0000481 a rdf:Property ;
rdfs:label "has respondents" ;
rdfs:comment "A relation between a measure (e.g. a survey) and the measure's respondents (people who respond). Respondents can be types or groups of people or people with a specific relationship to the main person of interest in the measure." ;
rdfs:range xsd:string .
obo:SCDO_0000482 a rdf:Property ;
rdfs:label "has target population" ;
rdfs:comment "A relation between a measure (e.g. a survey) and the population that the measure was designed to target." ;
rdfs:range xsd:string .
obo:SCDO_0000484 a rdf:Property ;
rdfs:label "has translations" ;
rdfs:comment "An account of known translations of a measure into other languages (other than English)." ;
rdfs:range xsd:string .
obo:SCDO_0000486 a rdf:Property ;
rdfs:label "has_application_toward" ;
rdfs:comment "A relation between a planned process and an objective it can be used to achieve." ;
rdfs:range xsd:string .
obo:SCDO_0000660 a rdf:Property ;
rdfs:label "caused or contributed to by" ;
rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (a genotype or genetic variation) where the entity has a causal role for the condition." ;
rdfs:range .
obo:SCDO_0000661 a rdf:Property ;
rdfs:label "is caused by" ;
rdfs:range xsd:string .
obo:SCDO_0000662 a rdf:Property ;
rdfs:label "is characterised by" ;
rdfs:comment "A relationship between a condition (a phenotype or disease) and a description of distinctive characteristics or essential features." ;
rdfs:range xsd:string .
obo:SCDO_0000772 a rdf:Property ;
rdfs:label "mortality modified by" ;
rdfs:comment "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the mortality (due to the phenotype) of the SCD sufferer." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000005 .
obo:SCDO_0000929 a rdf:Property ;
rdfs:label "property has curation status" ;
rdfs:comment "Description inherent in name (not provided by source)" ;
rdfs:range xsd:string .
obo:SCDO_0001033 a rdf:Property ;
rdfs:label "selection criteria met" ;
rdfs:comment "A relation between a selected entity and the predefined criteria that were met by the entity and that made it eligible for selection." ;
rdfs:range xsd:string .
obo:SCDO_0001139 a rdf:Property ;
rdfs:label "temporal pattern modified by" ;
rdfs:comment "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the temporal pattern of the phenotype. Temporal pattern is defined as \"The speed at which disease manifestations appear and develop.\" (HPO)" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:SCDO_1000005 .
obo:SCDO_0001222 a rdf:Property ;
rdfs:label "validated for age ranges" ;
rdfs:comment "A relation between a measure and the age ranges for which the measure has been validated." ;
rdfs:range xsd:string .
obo:SCDO_0001335 a rdf:Property ;
rdfs:label "freely available" ;
rdfs:comment "A relation between a measure (e.g. a survey) and an indication of whether the measure is freely available." ;
rdfs:range xsd:string .
obo:SCDO_1000003 a rdf:Property ;
rdfs:label "has slider label" ;
rdfs:comment "Records the slider label used by REDCap for a data element that uses a slider to collect data." ;
rdfs:range xsd:string .
obo:SCDO_1000101 a rdf:Property ;
rdfs:label "curation status - complete" ;
rdfs:range xsd:string .
obo:SCDO_1000102 a rdf:Property ;
rdfs:label "curation status - incomplete" ;
rdfs:range xsd:string .
obo:SCDO_1000171 a rdf:Property ;
rdfs:label "has diagnostic device" ;
rdfs:comment "A relation between a Diagnostic Tool (test, method, assay, etc.) or the Diagnostic Measurement obtained from such a tool and a specific Diagnostic Device, where the Diagnostic Device is used in the application of the Diagnostic Tool or to obtain the Diagnostic Measurement." ;
rdfs:range .
obo:SCDO_1000180 a rdf:Property ;
rdfs:label "manifestation of" ;
rdfs:comment "A relationship that holds between a phenotype (i.e. manifestation) and a condition such as a disease (hemoglobinopathy), wherein the phenotype is evidence of the condition." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002201 .
obo:SCDO_1000182 a rdf:Property ;
rdfs:label "symptom of" ;
rdfs:comment "A relation between a phenotype that is a symptom (subjective evidence of disease perceived by the patient) and a disease." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002201 .
obo:SCDO_1000183 a rdf:Property ;
rdfs:label "causes or contributes to" ;
rdfs:comment "A relationship between 'a' and 'b', where 'a' has some causal role for 'b'." ;
rdfs:range .
obo:SCDO_1000188 a rdf:Property ;
rdfs:label "studied in" ;
rdfs:comment "A relation between a condition (Hemoglobinopathy) and a form of research (type of study) that the condition was studied in." ;
rdfs:range .
obo:SCDO_1000189 a rdf:Property ;
rdfs:label "associated via" ;
rdfs:comment "A relation between a condition (disease or phenotype) and a type of linking association (e.g. age of onset association)." ;
rdfs:range .
obo:SCDO_1000203 a rdf:Property ;
rdfs:label "has risk factor" ;
rdfs:comment "A relation between a condition (disease or phenotype) and an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of the condition." ;
rdfs:range .
obo:SCDO_1000204 a rdf:Property ;
rdfs:label "risk factor for" ;
rdfs:comment "A relation between an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of a condition and the condition (disease or phenotype) that it increases the likelihood of." ;
rdfs:range .
obo:SCDO_1000288 a rdf:Property ;
rdfs:label "existence in other ontologies" ;
rdfs:comment "An indication of whether a term/class already exists in other ontologies. Only used for term (descriptions) that were not taken directly from an existing ontology." ;
rdfs:range xsd:string .
obo:SCDO_1000741 a rdf:Property ;
rdfs:label "has redcap validation" ;
rdfs:comment "Records the type of validation used for a data element in REDCap." ;
rdfs:range xsd:string .
obo:SCDO_1000748 a rdf:Property ;
rdfs:label "custom alignment" ;
rdfs:comment "Records the custom alignment of a data element in REDCap." ;
rdfs:range xsd:string .
obo:SCDO_1000773 a rdf:Property ;
rdfs:label "diagnosed using finding" ;
rdfs:comment "A relationship between an Abnormal Phenotype that is a diagnosis of a condition and a Phenotype that is a finding from a Diagnostic Measurement, where the Phenotype that is a finding is used as evidence to diagnose patients with the Abnormal Phenotype that is a diagnosis." ;
rdfs:range obo:OGMS_0000023 .
obo:SCDO_1000845 a rdf:Property ;
rdfs:label "autocomplete" ;
rdfs:comment "An indication of whether or not a data element with a dropdown field should be autocompleted. Annotation is either \"yes\" or \"no\"." ;
rdfs:range xsd:string .
obo:SCDO_1000846 a rdf:Property ;
rdfs:label "show slider" ;
rdfs:comment "An indication of whether or not a data element with a slider field should display the slider's number values. Annotation is either \"yes\" or \"no\"." ;
rdfs:range xsd:string .
obo:SCDO_1000910 a rdf:Property ;
rdfs:label "previous identifier" ;
rdfs:comment "Used to record the identifier that had been used previously but is no longer in use." ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:label "abbreviation" ;
rdfs:comment "A shortened form of a word or phrase, in this case a class/term. It consists of a group of letters taken from the word or phrase." ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:label "discarded/obsoleted synonym" ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:label "plural form" ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:label "layperson term" ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:label "associated with" ;
rdfs:range .