PREFIX obo: <http://purl.obolibrary.org/obo/>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

obo:BFO_0000006 a rdfs:Class ;
  rdfs:label "spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:RO_0002150 a rdf:Property ;
  rdfs:label "continuous with"@en ;
  rdfs:comment "X continuous_with Y if and only if X and Y share a fiat boundary." ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:BFO_0000050 a rdf:Property ;
  rdfs:label "part of"@en ;
  rdfs:comment "a core relation that holds between a part and its whole"@en ;
  rdfs:seeAlso <http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections> , <http://ontologydesignpatterns.org/wiki/Submissions:PartOf> , <http://www.obofoundry.org/ro/#OBO_REL:part_of> , <https://wiki.geneontology.org/Part_of> ;
  rdfs:range obo:BFO_0000004 , obo:BFO_0000003 , obo:BFO_0000019 , obo:BFO_0000020 , obo:BFO_0000031 , obo:BFO_0000017 , obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002176 a rdf:Property ;
  rdfs:label "connects"@en ;
  rdfs:comment "c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern> , <https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern> ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002220 a rdf:Property ;
  rdfs:label "adjacent to"@en ;
  rdfs:comment "x adjacent to y if and only if x and y share a boundary." ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002163 .

obo:RO_0002506 a rdf:Property ;
  rdfs:label "causal relation between entities" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0010002 a rdf:Property ;
  rdfs:label "is carrier of"@en ;
  rdfs:comment "*b* is carrier of *c* at time *t* if and only if *c* *g-depends on* *b* at *t*" ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000031 .

obo:RO_0002205 a rdf:Property ;
  rdfs:label "has gene product"@en ;
  rdfs:comment "x has gene product y if and only if x is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from y" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002202 a rdf:Property ;
  rdfs:label "develops from"@en ;
  rdfs:comment "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:RO_0000087 a rdf:Property ;
  rdfs:label "has role"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000023 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0002215 a rdf:Property ;
  rdfs:label "capable of"@en ;
  rdfs:comment "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002216 .

obo:RO_0002330 a rdf:Property ;
  rdfs:label "genomically related to"@en ;
  rdfs:comment "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 .

obo:RO_0000085 a rdf:Property ;
  rdfs:label "has function"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000034 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0002258 a rdf:Property ;
  rdfs:label "developmentally preceded by"@en ;
  rdfs:comment "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002324 .

obo:RO_0000091 a rdf:Property ;
  rdfs:label "has disposition"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000016 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0002206 a rdf:Property ;
  rdfs:label "expressed in"@en ;
  rdfs:comment "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0000056 a rdf:Property ;
  rdfs:label "participates in"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000003 .

obo:RO_0002487 a rdf:Property ;
  rdfs:label "relation between physical entity and a process or stage" ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000003 .

obo:RO_0002214 a rdf:Property ;
  rdfs:label "has prototype"@en ;
  rdfs:comment "x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a \"canonical\" heart, which participates in blood circulation." ;
  rdfs:range obo:BFO_0000002 , obo:BFO_0000015 .

obo:RO_0001025 a rdf:Property ;
  rdfs:label "located in"@en ;
  rdfs:comment "a relation between two independent continuants, the target and the location, in which the target is entirely within the location"@en ;
  rdfs:seeAlso <https://wiki.geneontology.org/Located_in> ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002566 a rdf:Property ;
  rdfs:label "causally influences" ;
  rdfs:comment "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002506 .

obo:RO_0002204 a rdf:Property ;
  rdfs:label "gene product of"@en ;
  rdfs:comment "definition \"x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from x\"" ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_HOM0000000 a rdf:Property ;
  rdfs:label "in similarity relationship with" ;
  rdfs:comment "Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison." ;
  rdfs:seeAlso obo:HOM_0000000 ;
  rdfs:range obo:BFO_0000002 , obo:BFO_0000003 .

obo:RO_0002572 a rdf:Property ;
  rdfs:label "luminal space of" ;
  rdfs:comment "s is luminal space of x iff s is lumen_of x and s is an immaterial entity" ;
  rdfs:domain obo:BFO_0000141 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002571 .

obo:RO_0002310 a rdfs:Class ;
  rdfs:label "exposure event or process" ;
  rdfs:comment "A process occurring within or in the vicinity of an organism that exerts some causal influence on the organism via the interaction between an exposure stimulus and an exposure receptor. The exposure stimulus may be a process, material entity or condition (for example, lack of nutrients). The exposure receptor can be an organism, organism population or a part of an organism." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/pull/173> ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:BFO_0000062 a rdf:Property ;
  rdfs:label "preceded by"@en ;
  rdfs:comment "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002086 .

obo:BFO_0000063 a rdf:Property ;
  rdfs:label "precedes"@en ;
  rdfs:comment "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002091 a rdf:Property ;
  rdfs:label "starts during"@en ;
  rdfs:comment "X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002010 a rdf:Property ;
  rdfs:label "regulates in other organism" ;
  rdfs:comment "x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0002501 a rdf:Property ;
  rdfs:label "causal relation between processes" ;
  rdfs:comment "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002337 a rdf:Property ;
  rdfs:label "related via localization to"@en ;
  rdfs:comment "A relationship that holds via some process of localization" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000002 .

obo:RO_0002231 a rdf:Property ;
  rdfs:label "has start location"@en ;
  rdfs:comment "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002479 .

obo:RO_0002232 a rdf:Property ;
  rdfs:label "has end location"@en ;
  rdfs:comment "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002479 .

obo:RO_0002233 a rdf:Property ;
  rdfs:label "has input"@en ;
  rdfs:comment "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Has_input> ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0002211 a rdf:Property ;
  rdfs:label "regulates"@en ;
  rdfs:comment "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002411 .

obo:RO_0002018 a rdf:Property ;
  rdfs:label "has component process" ;
  rdfs:comment "w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002180 .

obo:RO_0002479 a rdf:Property ;
  rdfs:label "has part that occurs in" ;
  rdfs:comment "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000004 .

obo:BFO_0000066 a rdf:Property ;
  rdfs:label "occurs in"@en ;
  rdfs:comment "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ;
  rdfs:seeAlso <https://wiki.geneontology.org/Occurs_in> ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000004 .

obo:RO_0002332 a rdf:Property ;
  rdfs:label "regulates levels of"@en ;
  rdfs:comment "p regulates levels of c if p regulates some amount (PATO:0000070) of c" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002328 .

obo:BFO_0000055 a rdf:Property ;
  rdfs:label "realizes"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000017 .

obo:RO_0000057 a rdf:Property ;
  rdfs:label "has participant"@en ;
  rdfs:comment "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000002 .

obo:RO_0019000 a rdf:Property ;
  rdfs:label "regulates characteristic" ;
  rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:PATO_0000001 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002244 a rdf:Property ;
  rdfs:label "related via exposure to" ;
  rdfs:comment "Any relationship between an exposure event or process and any other entity." ;
  rdfs:domain obo:RO_0002310 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002222 a rdf:Property ;
  rdfs:label "temporally related to"@en ;
  rdfs:comment "A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 .

obo:RO_0002334 a rdf:Property ;
  rdfs:label "regulated by"@en ;
  rdfs:comment "inverse of regulates" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002427 .

obo:RO_0002414 a rdf:Property ;
  rdfs:label "transitively provides input for"@en ;
  rdfs:comment "transitive form of directly_provides_input_for" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0004047 .

obo:RO_0002012 a rdf:Property ;
  rdfs:label "occurrent part of" ;
  rdfs:comment "A part of relation that applies only between occurrents." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002418 , obo:BFO_0000050 .

obo:BFO_0000019 a rdfs:Class ;
  rdfs:label "quality"@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:RO_0000059 a rdf:Property ;
  rdfs:label "concretizes"@en ;
  rdfs:comment "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ;
  rdfs:domain obo:BFO_0000020 ;
  rdfs:range obo:BFO_0000031 .

obo:RO_0002573 a rdf:Property ;
  rdfs:label "has modifier" ;
  rdfs:comment "A relation that holds between an attribute or a qualifier and another attribute." ;
  rdfs:domain obo:BFO_0000020 ;
  rdfs:range obo:BFO_0000020 .

obo:GO_0019107 a rdfs:Class ;
  rdfs:label "myristoyltransferase activity" ;
  rdfs:comment "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." ;
  rdfs:subClassOf obo:GO_0003674 .

obo:PATO_0001199 a rdfs:Class ;
  rdfs:label "linear" ;
  rdfs:comment "A shape quality inhering in a bearer by virtue of the bearer's being narrow, with the two opposite margins parallel." ;
  rdfs:subClassOf obo:PATO_0000001 .

obo:RO_0015006 a rdf:Property ;
  rdfs:label "different in magnitude relative to" ;
  rdfs:comment "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." ;
  rdfs:domain obo:PATO_0000001 ;
  rdfs:range obo:PATO_0000001 .

obo:RO_0015007 a rdf:Property ;
  rdfs:label "increased in magnitude relative to" ;
  rdfs:comment "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." ;
  rdfs:domain obo:PATO_0000001 ;
  rdfs:range obo:PATO_0000001 ;
  rdfs:subPropertyOf obo:RO_0015006 .

obo:RO_0015008 a rdf:Property ;
  rdfs:label "decreased in magnitude relative to" ;
  rdfs:comment "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." ;
  rdfs:domain obo:PATO_0000001 ;
  rdfs:range obo:PATO_0000001 ;
  rdfs:subPropertyOf obo:RO_0015006 .

obo:RO_0002577 a rdfs:Class ;
  rdfs:label "system" ;
  rdfs:comment "A material entity consisting of multiple components that are causally integrated." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:RO_0002375 a rdf:Property ;
  rdfs:label "in branching relationship with"@en ;
  rdfs:comment "A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/branching_part_of.png> , <https://github.com/obophenotype/uberon/issues/170> ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0011008 a rdf:Property ;
  rdfs:label "increases by expression quantity of" ;
  rdfs:comment """The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B.

For example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011024 .

obo:RO_0009004 a rdf:Property ;
  rdfs:label "has consumer"@en ;
  rdfs:comment "'has consumer' is a relation between a material entity and an organism in which the former can normally be digested or otherwise absorbed by the latter without immediate or persistent ill effect."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:OBI_0100026 .

obo:RO_0011010 a rdf:Property ;
  rdfs:label "directly negatively regulates quantity of" ;
  rdfs:comment "The entity A has an activity that directly negatively regulates the quantity of B." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011021 .

obo:RO_0009003 a rdf:Property ;
  rdfs:label "immersed in"@en ;
  rdfs:comment "\"immersed in\" is a relation between a (physical) entity and a fluid substance in which the entity is wholely or substantially surrounded by the substance."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0002450 a rdf:Property ;
  rdfs:label "directly positively regulates activity of" ;
  rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002448 .

obo:RO_0011015 a rdf:Property ;
  rdfs:label "stabilizes quantity of" ;
  rdfs:comment "An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011009 .

obo:RO_0011004 a rdf:Property ;
  rdfs:label "indirectly regulates activity of"@en ;
  rdfs:comment "The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011002 .

obo:RO_0002510 a rdf:Property ;
  rdfs:label "transcribed from" ;
  rdfs:comment "x is transcribed from y if and only if x is synthesized from template y" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0003000 a rdf:Property ;
  rdfs:label "produces"@en ;
  rdfs:comment "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0002449 a rdf:Property ;
  rdfs:label "directly negatively regulates activity of" ;
  rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002448 .

obo:RO_0002595 a rdf:Property ;
  rdfs:label "causal relation between material entity and a process" ;
  rdfs:comment "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002509 a rdf:Property ;
  rdfs:label "determined by part of" ;
  rdfs:comment "s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w." ;
  rdfs:domain obo:RO_0002577 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002506 , obo:RO_0002131 .

obo:RO_0002325 a rdf:Property ;
  rdfs:label "colocalizes with"@en ;
  rdfs:comment "a colocalizes_with b if and only if  a is transiently or peripherally associated with b[GO]." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002473 a rdf:Property ;
  rdfs:label "composed primarily of" ;
  rdfs:comment "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002448 a rdf:Property ;
  rdfs:label "directly regulates activity of" ;
  rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.

A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011002 , obo:RO_0002436 .

obo:RO_0011009 a rdf:Property ;
  rdfs:label "directly positively regulates quantity of" ;
  rdfs:comment "The entity A has an activity that directly positively regulates the quantity of B." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011021 .

obo:RO_0002512 a rdf:Property ;
  rdfs:label "ribosomal translation of" ;
  rdfs:comment "x is the ribosomal translation of y if and only if a ribosome reads x through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces y" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002434 a rdf:Property ;
  rdfs:label "interacts with" ;
  rdfs:comment "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/interaction-relations/> ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0001021 a rdf:Property ;
  rdfs:label "is autoimmune trigger for"@en ;
  rdfs:comment "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0002002 a rdf:Property ;
  rdfs:label "has 2D boundary"@en ;
  rdfs:comment "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity"@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000141 ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002437 a rdf:Property ;
  rdfs:label "biotically interacts with" ;
  rdfs:comment "An interaction relationship in which at least one of the partners is an organism and the other is either an organism or an abiotic entity with which the organism interacts." ;
  rdfs:seeAlso <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> , <http://eol.org/schema/terms/interactsWith> ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002434 , obo:RO_0002321 .

obo:RO_0002570 a rdf:Property ;
  rdfs:label "conduit for" ;
  rdfs:comment "x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0003003 a rdf:Property ;
  rdfs:label "increases expression of" ;
  rdfs:comment "Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002450 .

obo:RO_0011014 a rdf:Property ;
  rdfs:label "destabilizes quantity of" ;
  rdfs:comment "An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011010 .

obo:RO_0011003 a rdf:Property ;
  rdfs:label "regulates quantity of" ;
  rdfs:comment "The entity A has an activity that regulates the quantity or abundance or concentration of the entity B." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002566 .

obo:RO_0009001 a rdf:Property ;
  rdfs:label "has substance added"@en ;
  rdfs:comment "\"has substance added\" is a relation existing between a (physical) entity and a substance in which the entity has had the substance added to it at some point in time."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0001020 a rdf:Property ;
  rdfs:label "is allergic trigger for"@en ;
  rdfs:comment "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0003002 a rdf:Property ;
  rdfs:label "represses expression of" ;
  rdfs:comment "Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002449 .

obo:RO_0009002 a rdf:Property ;
  rdfs:label "has substance removed"@en ;
  rdfs:comment "\"has substance removed\" is a relation existing between two physical entities in which the first entity has had the second entity (a substance) removed from it at some point in time."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0002513 a rdf:Property ;
  rdfs:label "ribosomally translates to" ;
  rdfs:comment "inverse of ribosomal translation of" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002248 a rdf:Property ;
  rdfs:label "has active ingredient" ;
  rdfs:comment "A relationship that holds between a substance and a chemical entity, if the chemical entity is part of the substance, and the chemical entity forms the biologically active component of the substance." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0011013 a rdf:Property ;
  rdfs:label "indirectly positively regulates activity of" ;
  rdfs:comment "The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011004 .

obo:RO_0011002 a rdf:Property ;
  rdfs:label "regulates activity of" ;
  rdfs:comment "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002566 .

obo:RO_0002507 a rdf:Property ;
  rdfs:label "determined by" ;
  rdfs:comment "s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s." ;
  rdfs:domain obo:RO_0002577 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002509 , obo:RO_0002559 , obo:BFO_0000050 .

obo:RO_0011007 a rdf:Property ;
  rdfs:label "decreases by repression quantity of" ;
  rdfs:comment """The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B.

For example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B.""" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0011023 .

obo:RO_0003001 a rdf:Property ;
  rdfs:label "produced by"@en ;
  rdfs:comment "a produced_by b iff some process that occurs_in b has_output a." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0002532 a rdfs:Class ;
  rdfs:label "sequentially ordered entity" ;
  rdfs:comment "Any entity that is ordered in discrete units along a linear axis." .

obo:RO_0002514 a rdf:Property ;
  rdfs:label "sequentially related to" ;
  rdfs:comment "A relation that holds between two entities that have the property of being sequences or having sequences. " ;
  rdfs:domain obo:RO_0002532 ;
  rdfs:range obo:RO_0002532 .

obo:RO_0002524 a rdf:Property ;
  rdfs:label "has subsequence" ;
  rdfs:comment "x has subsequence y iff all of the sequence parts of y are sequence parts of x" ;
  rdfs:domain obo:RO_0002532 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002522 , obo:RO_0002526 , obo:BFO_0000051 .

obo:BFO_0000031 a rdfs:Class ;
  rdfs:label "generically dependent continuant"@en ;
  rdfs:comment "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])"@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:RO_0002200 a rdf:Property ;
  rdfs:label "has phenotype"@en ;
  rdfs:comment "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." ;
  rdfs:range obo:UPHENO_0001001 ;
  rdfs:subPropertyOf obo:RO_0016001 .

obo:RO_0000058 a rdf:Property ;
  rdfs:label "is concretized as"@en ;
  rdfs:comment "A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants."@en ;
  rdfs:domain obo:BFO_0000031 ;
  rdfs:range obo:BFO_0000020 .

obo:RO_0010001 a rdf:Property ;
  rdfs:label "generically depends on" ;
  rdfs:comment "A generically dependent continuant *b* generically depends on an independent continuant *c* at time *t* means: there inheres in *c* a specifically deendent continuant which concretizes *b* at *t*." ;
  rdfs:domain obo:BFO_0000031 ;
  rdfs:range obo:BFO_0000004 .

obo:BFO_0000034 a rdfs:Class ;
  rdfs:label "function"@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:RO_0004000 a rdf:Property ;
  rdfs:label "condition has genetic basis in" ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004028 a rdf:Property ;
  rdfs:label "realized in response to stimulus" ;
  rdfs:comment "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0000079 a rdf:Property ;
  rdfs:label "function of"@en ;
  rdfs:comment "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000034 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:BFO_0000054 a rdf:Property ;
  rdfs:label "realized in"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000015 .

obo:RO_0009501 a rdf:Property ;
  rdfs:label "realized in response to"@en ;
  rdfs:comment "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." ;
  rdfs:seeAlso <https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit> ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:BFO_0000017 a rdfs:Class ;
  rdfs:label "realizable entity"@en ;
  rdfs:comment "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:UBERON_0000465 a rdfs:Class ;
  rdfs:label "material anatomical entity" ;
  rdfs:comment "Anatomical entity that has mass." ;
  rdfs:subClassOf obo:BFO_0000040 , obo:UBERON_0001062 .

obo:RO_0002256 a rdf:Property ;
  rdfs:label "developmentally induced by"@en ;
  rdfs:comment "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T" ;
  rdfs:domain obo:UBERON_0000465 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:RO_0002254 a rdf:Property ;
  rdfs:label "has developmental contribution from"@en ;
  rdfs:comment "x has developmental contribution from y iff x has some part z such that z develops from y"@en ;
  rdfs:domain obo:UBERON_0001062 ;
  rdfs:range obo:UBERON_0001062 ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:RO_0002104 a rdf:Property ;
  rdfs:label "has plasma membrane part"@en ;
  rdfs:comment "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." ;
  rdfs:domain obo:UBERON_0000465 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002384 a rdf:Property ;
  rdfs:label "has developmental potential involving"@en ;
  rdfs:comment "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)."@en ;
  rdfs:domain obo:UBERON_0001062 ;
  rdfs:range obo:UBERON_0001062 ;
  rdfs:subPropertyOf obo:RO_0002324 .

obo:RO_0002226 a rdf:Property ;
  rdfs:label "develops in"@en ;
  rdfs:comment "x develops_in y if x is located in y whilst x is developing" ;
  rdfs:domain obo:UBERON_0001062 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:GO_0004842 a rdfs:Class ;
  rdfs:label "ubiquitin-protein transferase activity" ;
  rdfs:comment "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." ;
  rdfs:subClassOf obo:GO_0003674 .

obo:UBERON_0001062 a rdfs:Class ;
  rdfs:label "anatomical entity" ;
  rdfs:comment "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." ;
  rdfs:subClassOf obo:BFO_0000004 .

<http://xmlns.com/foaf/0.1/image> a rdfs:Class .

obo:RO_0002026 a rdf:Property ;
  rdfs:label "in register with"@en ;
  rdfs:comment """A relationship that holds between two images, A and B, where:
A depicts X;
B depicts Y;
X and Y are both of type T'
C is a 2 layer image consiting of layers A and B;
A and B are aligned in C according to a shared co-ordinate framework so that common features of X and Y are co-incident with each other.
Note: A and B may be 2D or 3D.
Examples include: the relationship between two channels collected simultaneously from a confocal microscope; the relationship between an image dpeicting X and a painted annotation layer that delineates regions of X; the relationship between the tracing of a neuron on an EM stack and the co-ordinate space of the stack; the relationship between two separately collected images that have been brought into register via some image registration software.""" ;
  rdfs:domain <http://xmlns.com/foaf/0.1/image> ;
  rdfs:range <http://xmlns.com/foaf/0.1/image> ;
  rdfs:subPropertyOf obo:RO_0002323 .

<http://www.w3.org/2003/11/swrl#Variable> a rdfs:Class .

obo:BFO_0000141 a rdfs:Class ;
  rdfs:label "immaterial entity"@en ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:UBERON_0000122 a rdfs:Class ;
  rdfs:label "neuron projection bundle" ;
  rdfs:comment "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:RO_0002551 a rdf:Property ;
  rdfs:label "has skeleton" ;
  rdfs:comment "A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision." ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002111 a rdf:Property ;
  rdfs:label "releases neurotransmitter"@en ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:BFO_0000040 .

obo:RO_0002177 a rdf:Property ;
  rdfs:label "attached to part of"@en ;
  rdfs:comment "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:RO_0002567 , obo:RO_0002323 .

obo:RO_0002132 a rdf:Property ;
  rdfs:label "has fasciculating neuron projection"@en ;
  rdfs:comment "The relation between a neuron projection bundle and a neuron projection that is fasciculated with it."@en ;
  rdfs:domain obo:UBERON_0000122 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002004 a rdf:Property ;
  rdfs:label "tracheates"@en ;
  rdfs:comment "The relationship that holds between a trachea or tracheole and an antomical structure that is contained in (and so provides an oxygen supply to)." ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:RO_0001025 .

obo:RO_0002373 a rdf:Property ;
  rdfs:label "has muscle insertion"@en ;
  rdfs:comment "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone."@en ;
  rdfs:seeAlso <http://dbpedia.org/property/insertion> ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:RO_0002567 , obo:RO_0002371 .

obo:RO_0002567 a rdf:Property ;
  rdfs:label "biomechanically related to" ;
  rdfs:comment "A relation that holds between elements of a musculoskeletal system or its analogs." ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:RO_0002328 .

obo:RO_0002005 a rdf:Property ;
  rdfs:label "innervated_by"@en ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000122 .

obo:RO_0002576 a rdf:Property ;
  rdfs:label "skeleton of" ;
  rdfs:comment "inverse of has skeleton" ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0002134 a rdf:Property ;
  rdfs:label "innervates"@en ;
  rdfs:comment """Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R."""@en ;
  rdfs:domain obo:UBERON_0000122 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002372 a rdf:Property ;
  rdfs:label "has muscle origin"@en ;
  rdfs:comment "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to."@en ;
  rdfs:seeAlso <http://dbpedia.org/property/origin> ;
  rdfs:domain obo:UBERON_0000061 ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:RO_0002567 , obo:RO_0002371 .

obo:BFO_0000040 a rdfs:Class ;
  rdfs:label "material entity"@en ;
  rdfs:comment "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:UBERON_0010000 a rdfs:Class ;
  rdfs:label "multicellular anatomical structure" ;
  rdfs:comment "An anatomical structure that has more than one cell as a part." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:RO_0002207 a rdf:Property ;
  rdfs:label "directly develops from"@en ;
  rdfs:comment "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0002202 .

obo:CL_0000101 a rdfs:Class ;
  rdfs:label "sensory neuron" ;
  rdfs:comment "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." ;
  rdfs:subClassOf obo:CL_0000540 .

obo:RO_0002130 a rdf:Property ;
  rdfs:label "has synaptic terminal in"@en ;
  rdfs:comment "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." ;
  rdfs:domain obo:CL_0000540 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0015004 a rdf:Property ;
  rdfs:label "has characterizing marker set" ;
  rdfs:comment "A relation that applies between a cell type and a set of markers that can be used to uniquely identify that cell type." ;
  rdfs:domain obo:CL_0000000 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002100 a rdf:Property ;
  rdfs:label "has soma location"@en ;
  rdfs:comment "Relation between a neuron and a material anatomical entity that its soma is part of."@en ;
  rdfs:domain obo:CL_0000540 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0015016 a rdf:Property ;
  rdfs:label "has low plasma membrane amount" ;
  rdfs:comment "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." ;
  rdfs:domain obo:CL_0000000 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:RO_0002104 .

obo:RO_0002101 a rdf:Property ;
  rdfs:label "fasciculates with"@en ;
  rdfs:comment """relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
"""@en ;
  rdfs:domain obo:CL_0000540 ;
  rdfs:range obo:UBERON_0000122 ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0013007 a rdf:Property ;
  rdfs:label "has sensory dendrite in"@en ;
  rdfs:comment "Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite." ;
  rdfs:domain obo:CL_0000101 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002360 .

obo:RO_0002113 a rdf:Property ;
  rdfs:label "has presynaptic terminal in"@en ;
  rdfs:comment "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."@en ;
  rdfs:domain obo:CL_0000540 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002130 .

obo:RO_0002102 a rdf:Property ;
  rdfs:label "axon synapses in"@en ;
  rdfs:comment "Relation between a neuron and some structure its axon forms (chemical) synapses in."@en ;
  rdfs:domain obo:CL_0000540 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002113 .

obo:RO_0002121 a rdf:Property ;
  rdfs:label "dendrite synapsed in"@en ;
  rdfs:comment """Relation between a neuron and some structure  (e.g.- a brain region) in which its dendrite receives synaptic input.

\t"""@en ;
  rdfs:domain obo:CL_0000540 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002110 .

obo:RO_0002009 a rdf:Property ;
  rdfs:label "cell expresses" ;
  rdfs:comment "A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g." ;
  rdfs:domain obo:CL_0000000 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002292 .

obo:RO_0015015 a rdf:Property ;
  rdfs:label "has high plasma membrane amount" ;
  rdfs:comment "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." ;
  rdfs:domain obo:CL_0000000 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:RO_0002104 .

obo:RO_0002110 a rdf:Property ;
  rdfs:label "has postsynaptic terminal in"@en ;
  rdfs:comment "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "@en ;
  rdfs:domain obo:CL_0000540 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002130 .

obo:CL_0000000 a rdfs:Class ;
  rdfs:label "cell" ;
  rdfs:comment "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:BFO_0000023 a rdfs:Class ;
  rdfs:label "role"@en ;
  rdfs:comment "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts."@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:GO_0008150 a rdfs:Class ;
  rdfs:label "biological_process" ;
  rdfs:comment "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." .

obo:RO_0002295 a rdf:Property ;
  rdfs:label "results in developmental progression of"@en ;
  rdfs:comment "p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Ontology_extensions> ;
  rdfs:domain obo:GO_0008150 ;
  rdfs:range obo:UBERON_0001062 ;
  rdfs:subPropertyOf obo:RO_0002324 .

obo:GO_0003674 a rdfs:Class ;
  rdfs:label "molecular_function" ;
  rdfs:comment "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." .

obo:BFO_0000016 a rdfs:Class ;
  rdfs:label "disposition"@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:IAO_0000030 a rdfs:Class ;
  rdfs:label "information content entity"@en ;
  rdfs:subClassOf obo:BFO_0000031 .

obo:UBERON_0000466 a rdfs:Class ;
  rdfs:label "immaterial anatomical entity" ;
  rdfs:comment "Anatomical entity that has no mass." ;
  rdfs:subClassOf obo:BFO_0000141 , obo:UBERON_0001062 .

obo:GO_0005634 a rdfs:Class ;
  rdfs:label "nucleus" ;
  rdfs:comment "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." .

obo:RO_0002476 a rdf:Property ;
  rdfs:label "child nucleus of" ;
  rdfs:comment "c is a child nucleus of d if and only if c and d are both nuclei and parts of cells c' and d', where c' is derived from d' by mitosis and the genetic material in c is a copy of the generic material in d" ;
  rdfs:domain obo:GO_0005634 ;
  rdfs:range obo:GO_0005634 ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:ENVO_01000739 a rdfs:Class ;
  rdfs:label "habitat"@en ;
  rdfs:comment "An environmental system which can sustain and allow the growth of an ecological population." ;
  rdfs:subClassOf obo:ENVO_01000254 .

obo:BFO_0000004 a rdfs:Class ;
  rdfs:label "independent continuant"@en ;
  rdfs:comment "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:BFO_0000015 a rdfs:Class ;
  rdfs:label "process"@en ;
  rdfs:comment "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:BFO_0000002 a rdfs:Class ;
  rdfs:label "continuant"@en ;
  rdfs:comment "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en .

obo:CL_0000540 a rdfs:Class ;
  rdfs:label "neuron" ;
  rdfs:comment "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:RO_0002534 a rdfs:Class ;
  rdfs:label "sequence bearer" ;
  rdfs:comment "Any entity that can be divided into parts such that each part is an atomical unit of a sequence" ;
  rdfs:subClassOf obo:RO_0002532 .

obo:UBERON_0000061 a rdfs:Class ;
  rdfs:label "anatomical structure" ;
  rdfs:comment "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:GO_0016301 a rdfs:Class ;
  rdfs:label "kinase activity" ;
  rdfs:comment "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." ;
  rdfs:subClassOf obo:GO_0003674 .

obo:OBI_0100026 a rdfs:Class ;
  rdfs:label "organism"@en ;
  rdfs:comment "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:RO_0002574 a rdf:Property ;
  rdfs:label "participates in a biotic-biotic interaction with" ;
  rdfs:seeAlso <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> ;
  rdfs:domain obo:OBI_0100026 ;
  rdfs:range obo:OBI_0100026 ;
  rdfs:subPropertyOf obo:RO_0002437 .

obo:RO_0008506 a rdf:Property ;
  rdfs:label "ecologically co-occurs with" ;
  rdfs:comment "An interaction relationship describing organisms that often occur together at the same time and space or in the same environment." ;
  rdfs:domain obo:OBI_0100026 ;
  rdfs:range obo:OBI_0100026 ;
  rdfs:subPropertyOf obo:RO_0002321 .

obo:RO_0002303 a rdf:Property ;
  rdfs:label "has habitat"@en ;
  rdfs:comment "x 'has habitat' y if and only if: x is an organism, y is a habitat, and y can sustain and allow the growth of a population of xs." ;
  rdfs:domain obo:OBI_0100026 ;
  rdfs:range obo:ENVO_01000254 ;
  rdfs:subPropertyOf obo:RO_0002321 .

obo:RO_0008509 a rdf:Property ;
  rdfs:label "has roost"@en ;
  rdfs:comment "x 'has roost' y if and only if: x is an organism, y is a habitat, and y can support rest behaviors x." ;
  rdfs:domain obo:OBI_0100026 ;
  rdfs:range obo:ENVO_01000739 ;
  rdfs:subPropertyOf obo:RO_0002303 .

obo:RO_0008505 a rdf:Property ;
  rdfs:label "creates habitat for" ;
  rdfs:comment "An interaction relationship wherein one organism creates a structure or environment that is lived in by another organism." ;
  rdfs:domain obo:OBI_0100026 ;
  rdfs:range obo:OBI_0100026 ;
  rdfs:subPropertyOf obo:RO_0002321 .

obo:OGMS_0000031 a rdfs:Class ;
  rdfs:label "disease" ;
  rdfs:comment "A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:RO_0004023 a rdf:Property ;
  rdfs:label "causal relationship with disease as subject" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0040035 , obo:RO_0002410 .

obo:RO_0004022 a rdf:Property ;
  rdfs:label "disease has basis in feature" ;
  rdfs:comment "A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range obo:UPHENO_0001001 ;
  rdfs:subPropertyOf obo:RO_0004019 , obo:RO_0002200 .

obo:RO_0004025 a rdf:Property ;
  rdfs:label "disease causes dysfunction of" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004024 a rdf:Property ;
  rdfs:label "disease causes disruption of" ;
  rdfs:comment "A relationship between a disease and a process where the disease process disrupts the execution of the process." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004027 a rdf:Property ;
  rdfs:label "disease has inflammation site" ;
  rdfs:comment "A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0004026 .

obo:RO_0004026 a rdf:Property ;
  rdfs:label "disease has location" ;
  rdfs:comment "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0040035 .

obo:RO_0004029 a rdf:Property ;
  rdfs:label "disease has feature" ;
  rdfs:comment "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0040035 .

obo:RO_0004019 a rdf:Property ;
  rdfs:label "disease has basis in" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0004023 , obo:RO_0004017 .

obo:RO_0002452 a rdf:Property ;
  rdfs:label "has symptom" ;
  rdfs:comment "A relation that holds between a disease or an organism and a phenotype" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range obo:UPHENO_0001001 ;
  rdfs:subPropertyOf obo:RO_0002200 .

obo:BFO_0000020 a rdfs:Class ;
  rdfs:label "specifically dependent continuant"@en ;
  rdfs:comment "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:UPHENO_0001001 a rdfs:Class ;
  rdfs:label "phenotype"@en ;
  rdfs:subClassOf obo:PATO_0000001 .

obo:ENVO_01000254 a rdfs:Class ;
  rdfs:label "environmental system" ;
  rdfs:comment "A system which has the disposition to environ one or more material entities." ;
  rdfs:subClassOf obo:RO_0002577 .

obo:PATO_0000001 a rdfs:Class ;
  rdfs:label "quality" ;
  rdfs:comment "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:RO_0002533 a rdfs:Class ;
  rdfs:label "sequence atomic unit" ;
  rdfs:comment "Any individual unit of a collection of like units arranged in a linear order" ;
  rdfs:subClassOf obo:RO_0002532 .

obo:CHEBI_50906 a rdfs:Class ;
  rdfs:subClassOf obo:PATO_0000001 .

obo:BFO_0000003 a rdfs:Class ;
  rdfs:label "occurrent"@en ;
  rdfs:comment "An entity that has temporal parts and that happens, unfolds or develops through time."@en .

obo:PATO_0002124 a rdfs:Class ;
  rdfs:label "laminar" ;
  rdfs:comment "A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer." ;
  rdfs:subClassOf obo:PATO_0000001 .

<https://w3id.org/linkml/Any> a rdfs:Class ;
  rdfs:comment "An unconstrained type or object" .

obo:PATO_0000402 a rdfs:Class ;
  rdfs:label "branched" ;
  rdfs:comment "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." ;
  rdfs:subClassOf obo:PATO_0000001 .

obo:BFO_0000051 a rdf:Property ;
  rdfs:label "has part"@en ;
  rdfs:comment "a core relation that holds between a whole and its part"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:BFO_0000060 a rdf:Property ;
  rdfs:label "obsolete preceded by"@en ;
  rdfs:comment """accidentally included in BFO 1.2 proposal
        - should have been BFO_0000062"""@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000067 a rdf:Property ;
  rdfs:label "contains process"@en ;
  rdfs:comment "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:ENVO_01003004 a rdf:Property ;
  rdfs:label "derives from part of"@en ;
  rdfs:comment "A relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist through the separation or transformation of a part of the old entity, and the new entity inherits a significant portion of the matter belonging to that part of the old entity."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0000111 a rdf:Property ;
  rdfs:label "editor preferred term"@en ;
  rdfs:comment "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000112 a rdf:Property ;
  rdfs:label "example of usage" ;
  rdfs:comment "A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold."@en ;
  rdfs:range xsd:string .

obo:IAO_0000114 a rdf:Property ;
  rdfs:label "has curation status"@en ;
  rdfs:range xsd:string .

obo:IAO_0000115 a rdf:Property ;
  rdfs:label "definition" ;
  rdfs:comment "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en ;
  rdfs:range xsd:string .

obo:IAO_0000116 a rdf:Property ;
  rdfs:label "editor note"@en ;
  rdfs:comment "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
  rdfs:range xsd:string .

obo:IAO_0000117 a rdf:Property ;
  rdfs:label "term editor"@en ;
  rdfs:comment "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
  rdfs:range xsd:string .

obo:IAO_0000118 a rdf:Property ;
  rdfs:label "alternative label"@en ;
  rdfs:comment "A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like."@en ;
  rdfs:range xsd:string .

obo:IAO_0000119 a rdf:Property ;
  rdfs:label "definition source"@en ;
  rdfs:comment "Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
  rdfs:range xsd:string .

obo:IAO_0000232 a rdf:Property ;
  rdfs:label "curator note"@en ;
  rdfs:comment "An administrative note of use for a curator but of no use for a user"@en ;
  rdfs:range xsd:string .

obo:IAO_0000233 a rdf:Property ;
  rdfs:label "term tracker item"@en ;
  rdfs:comment "An IRI or similar locator for a request or discussion of an ontology term."@en ;
  rdfs:range xsd:string .

obo:IAO_0000412 a rdf:Property ;
  rdfs:label "imported from"@en ;
  rdfs:comment "For external terms/classes, the ontology from which the term was imported"@en ;
  rdfs:range xsd:string .

obo:IAO_0000424 a rdf:Property ;
  rdfs:label "expand expression to"@en ;
  rdfs:comment "A macro expansion tag applied to an object property (or possibly a data property)  which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en ;
  rdfs:range xsd:string .

obo:IAO_0000425 a rdf:Property ;
  rdfs:label "expand assertion to"@en ;
  rdfs:comment "A macro expansion tag applied to an annotation property which can be expanded into a more detailed axiom."@en ;
  rdfs:range xsd:string .

obo:IAO_0000426 a rdf:Property ;
  rdfs:label "first order logic expression"@en ;
  rdfs:comment "An assertion that holds between an OWL Object Property and a string or literal, where the value of the string or literal is a Common Logic sentence of collection of sentences that define the Object Property." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:IAO_0000589 a rdf:Property ;
  rdfs:label "OBO foundry unique label"@en ;
  rdfs:comment "An alternative name for a class or property which is unique across the OBO Foundry."@en ;
  rdfs:range xsd:string .

obo:IAO_0000600 a rdf:Property ;
  rdfs:label "elucidation"@en ;
  rdfs:range xsd:string .

obo:IAO_0000700 a rdf:Property ;
  rdfs:label "has ontology root term"@en ;
  rdfs:comment "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."@en ;
  rdfs:range xsd:string .

obo:IAO_0100001 a rdf:Property ;
  rdfs:label "term replaced by"@en ;
  rdfs:comment "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en ;
  rdfs:range xsd:string .

obo:OMO_0002000 a rdf:Property ;
  rdfs:label "defined by construct" ;
  rdfs:comment "Links an annotation property to a SPARQL CONSTRUCT query which is meant to provide semantics for a shortcut relation." ;
  rdfs:range xsd:string .

obo:RO_0000052 a rdf:Property ;
  rdfs:label "characteristic of"@en ;
  rdfs:comment "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002314 .

obo:RO_0000053 a rdf:Property ;
  rdfs:label "has characteristic"@en ;
  rdfs:comment "Inverse of characteristic_of"@en ;
  rdfs:range obo:BFO_0000020 .

obo:RO_0000080 a rdf:Property ;
  rdfs:label "quality of"@en ;
  rdfs:comment "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000081 a rdf:Property ;
  rdfs:label "role of"@en ;
  rdfs:comment "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000086 a rdf:Property ;
  rdfs:label "has quality"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range obo:BFO_0000019 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0000092 a rdf:Property ;
  rdfs:label "disposition of"@en ;
  rdfs:comment "inverse of has disposition" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000300 a rdf:Property ;
  rdfs:label "obsolete in neural circuit with"@en ;
  rdfs:comment "OBSOLETE A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000301 a rdf:Property ;
  rdfs:label "obsolete upstream in neural circuit with"@en ;
  rdfs:comment "OBSOLETE A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next, in which the direction is from the last to the first."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000302 a rdf:Property ;
  rdfs:label "obsolete downstream in neural circuit with"@en ;
  rdfs:comment "OBSOLETE A relation that holds between a neuron that is synapsed_by another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_by the next, in which the direction is from the last to the first."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001000 a rdf:Property ;
  rdfs:label "derives from"@en ;
  rdfs:comment "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001001 a rdf:Property ;
  rdfs:label "derives into"@en ;
  rdfs:comment "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001015 a rdf:Property ;
  rdfs:label "location of"@en ;
  rdfs:comment "a relation between two independent continuants, the location and the target, in which the target is entirely within the location"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001018 a rdf:Property ;
  rdfs:label "obsolete contained in" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/693> ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001019 a rdf:Property ;
  rdfs:label "obsolete contains" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/693> ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001022 a rdf:Property ;
  rdfs:label "has allergic trigger"@en ;
  rdfs:comment "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0001023 a rdf:Property ;
  rdfs:label "has autoimmune trigger"@en ;
  rdfs:comment "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0001900 a rdf:Property ;
  rdfs:label "temporal interpretation" ;
  rdfs:comment "An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002000 a rdf:Property ;
  rdfs:label "2D boundary of"@en ;
  rdfs:comment "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002001 a rdf:Property ;
  rdfs:label "aligned with"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002003 a rdf:Property ;
  rdfs:label "electrically_synapsed_to" ;
  rdfs:comment "A relation that holds between two neurons that are electrically coupled via gap junctions." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002170 .

obo:RO_0002006 a rdf:Property ;
  rdfs:label "has synaptic terminal of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002007 a rdf:Property ;
  rdfs:label "bounding layer of"@en ;
  rdfs:comment """X outer_layer_of Y iff:
. X :continuant that bearer_of some PATO:laminar
. X part_of Y
. exists Z :surface
. X has_boundary Z
. Z boundary_of Y

has_boundary: http://purl.obolibrary.org/obo/RO_0002002
boundary_of: http://purl.obolibrary.org/obo/RO_0002000""" ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0002008 a rdf:Property ;
  rdfs:label "coincident with" ;
  rdfs:comment "A relation that holds between two linear structures that are approximately parallel to each other for their entire length and where either the two structures are adjacent to each other or one is part of the other." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002011 a rdf:Property ;
  rdfs:label "regulates transport of" ;
  rdfs:comment "A relationship that holds between a  process that regulates a transport process and the entity transported by that process." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002013 a rdf:Property ;
  rdfs:label "has regulatory component activity" ;
  rdfs:comment "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 , obo:RO_0002017 .

obo:RO_0002014 a rdf:Property ;
  rdfs:label "has negative regulatory component activity" ;
  rdfs:comment "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002335 , obo:RO_0002013 .

obo:RO_0002015 a rdf:Property ;
  rdfs:label "has positive regulatory component activity" ;
  rdfs:comment "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002336 , obo:RO_0002013 .

obo:RO_0002016 a rdf:Property ;
  rdfs:label "has necessary component activity" ;
  rdfs:comment "A has necessary component activity B if A and B are GO molecular functions  (GO_0003674), A has_component B and B is necessary for A.  For example,  ATPase coupled transporter activity has necessary component ATPase activity; transcript factor activity has necessary component DNA binding activity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002336 , obo:RO_0002017 .

obo:RO_0002017 a rdf:Property ;
  rdfs:label "has component activity" ;
  rdfs:comment "A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002018 .

obo:RO_0002019 a rdf:Property ;
  rdfs:label "has ligand" ;
  rdfs:comment "A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002233 .

obo:RO_0002020 a rdf:Property ;
  rdfs:label "transports" ;
  rdfs:comment "Holds between p and c when p is a transport process or transporter activity and the outcome of this p is to move c from one location to another." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002313 .

obo:RO_0002021 a rdf:Property ;
  rdfs:label "occurs across" ;
  rdfs:comment "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002479 .

obo:RO_0002022 a rdf:Property ;
  rdfs:label "directly regulated by" ;
  rdfs:comment "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002023 a rdf:Property ;
  rdfs:label "directly negatively regulated by" ;
  rdfs:comment "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002022 .

obo:RO_0002024 a rdf:Property ;
  rdfs:label "directly positively regulated by" ;
  rdfs:comment "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002022 .

obo:RO_0002025 a rdf:Property ;
  rdfs:label "has effector activity" ;
  rdfs:comment "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002017 .

obo:RO_0002029 a rdf:Property ;
  rdfs:label "has increased age-specific mortality rate"@en ;
  rdfs:comment "Then percentage of organisms in a population that die during some specified age range (age-specific mortality rate), minus the percentage that die in during the same age range in a wild-type population." ;
  rdfs:range xsd:short .

obo:RO_0002081 a rdf:Property ;
  rdfs:label "before or simultaneous with"@en ;
  rdfs:comment "Primitive instance level timing relation between events" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002082 a rdf:Property ;
  rdfs:label "simultaneous with"@en ;
  rdfs:comment "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002081 .

obo:RO_0002083 a rdf:Property ;
  rdfs:label "before"@en ;
  rdfs:comment "t1 before t2 iff:=  t1 before_or_simulataneous_with t2  and not (t1 simultaeous_with t2)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002081 .

obo:RO_0002084 a rdf:Property ;
  rdfs:label "during which ends"@en ;
  rdfs:comment "Previously had ID  http://purl.obolibrary.org/obo/RO_0002122 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point.  No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line.  Official ID now chosen from DOS ID range." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002085 a rdf:Property ;
  rdfs:label "encompasses"@en ;
  rdfs:comment "Previously had ID  http://purl.obolibrary.org/obo/RO_0002124 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point.  No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line.  Official ID now chosen from DOS ID range." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002088 .

obo:RO_0002086 a rdf:Property ;
  rdfs:label "ends after"@en ;
  rdfs:comment "X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002087 a rdf:Property ;
  rdfs:label "immediately preceded by"@en ;
  rdfs:comment "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000062 .

obo:RO_0002088 a rdf:Property ;
  rdfs:label "during which starts"@en ;
  rdfs:comment "Previously had ID  http://purl.obolibrary.org/obo/RO_0002123 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point.  No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line.  Official ID now chosen from DOS ID range." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002089 a rdf:Property ;
  rdfs:label "starts before"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002090 a rdf:Property ;
  rdfs:label "immediately precedes"@en ;
  rdfs:comment "X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000063 .

obo:RO_0002092 a rdf:Property ;
  rdfs:label "happens during"@en ;
  rdfs:comment "X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))"@en ;
  rdfs:seeAlso <https://wiki.geneontology.org/Happens_during> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002093 , obo:RO_0002091 .

obo:RO_0002093 a rdf:Property ;
  rdfs:label "ends during"@en ;
  rdfs:comment "X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). "@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002103 a rdf:Property ;
  rdfs:label "synapsed by"@en ;
  rdfs:comment "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002485 .

obo:RO_0002105 a rdf:Property ;
  rdfs:label "synapsed_via_type_Ib_bouton_to"@en ;
  rdfs:comment "A relation between a motor neuron and a muscle that it synapses to via a type Ib bouton." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002120 .

obo:RO_0002106 a rdf:Property ;
  rdfs:label "synapsed_via_type_Is_bouton_to"@en ;
  rdfs:comment "A relation between a motor neuron and a muscle that it synapses to via a type Is bouton." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002120 .

obo:RO_0002107 a rdf:Property ;
  rdfs:label "synapsed_via_type_II_bouton_to"@en ;
  rdfs:comment "A relation between a motor neuron and a muscle that it synapses to via a type II bouton." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002120 .

obo:RO_0002108 a rdf:Property ;
  rdfs:label "synapsed_by_via_type_II_bouton"@en ;
  rdfs:comment "Relation between a muscle and a motor neuron that synapses to it via a type II bouton." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002103 .

obo:RO_0002109 a rdf:Property ;
  rdfs:label "synapsed_by_via_type_Ib_bouton"@en ;
  rdfs:comment "Relation between a muscle and a motor neuron that synapses to it via a type Ib bouton." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002103 .

obo:RO_0002112 a rdf:Property ;
  rdfs:label "synapsed_by_via_type_Is_bouton"@en ;
  rdfs:comment "Relation between a muscle and a motor neuron that synapses to it via a type Is bouton." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002103 .

obo:RO_0002114 a rdf:Property ;
  rdfs:label "synapsed_via_type_III_bouton_to"@en ;
  rdfs:comment "A relation between a motor neuron and a muscle that it synapses to via a type III bouton." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002120 .

obo:RO_0002115 a rdf:Property ;
  rdfs:label "synapsed_by_via_type_III_bouton"@en ;
  rdfs:comment """Relation between a muscle and a motor neuron that synapses to it via a type III bouton.
""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002103 .

obo:RO_0002120 a rdf:Property ;
  rdfs:label "synapsed to"@en ;
  rdfs:comment """ Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
        """@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002486 .

obo:RO_0002131 a rdf:Property ;
  rdfs:label "overlaps"@en ;
  rdfs:comment "x overlaps y if and only if there exists some z such that x has part z and z part of y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002151 a rdf:Property ;
  rdfs:label "partially overlaps"@en ;
  rdfs:comment "x partially overlaps y iff there exists some z such that z is part of x and z is part of y, and it is also the case that neither x is part of y or y is part of x" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002156 a rdf:Property ;
  rdfs:label "derived by descent from" ;
  rdfs:comment "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002320 .

obo:RO_0002157 a rdf:Property ;
  rdfs:label "has derived by descendant" ;
  rdfs:comment "inverse of derived by descent from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002320 .

obo:RO_0002158 a rdf:Property ;
  rdfs:label "shares ancestor with" ;
  rdfs:comment "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002320 .

obo:RO_0002159 a rdf:Property ;
  rdfs:label "serially homologous to" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002320 .

obo:RO_0002160 a rdf:Property ;
  rdfs:label "only in taxon" ;
  rdfs:comment "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002162 .

obo:RO_0002161 a rdf:Property ;
  rdfs:label "never in taxon" ;
  rdfs:comment "x never in taxon T if and only if T is a class, and x does not instantiate the class expression \"in taxon some T\". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002172 .

obo:RO_0002162 a rdf:Property ;
  rdfs:label "in taxon" ;
  rdfs:comment "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range obo:OBI_0100026 ;
  rdfs:subPropertyOf obo:RO_0002320 .

obo:RO_0002163 a rdf:Property ;
  rdfs:label "spatially disjoint from" ;
  rdfs:comment "A is spatially_disjoint_from B if and only if they have no parts in common" ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002170 a rdf:Property ;
  rdfs:label "connected to"@en ;
  rdfs:comment "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern> , <https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002171 a rdf:Property ;
  rdfs:label "mutually spatially disjoint with"@en ;
  rdfs:comment "A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B." ;
  rdfs:seeAlso obo:RO_0002163 , <https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002420 .

obo:RO_0002172 a rdf:Property ;
  rdfs:label "taxonomic class assertion"@en ;
  rdfs:comment "An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002420 .

obo:RO_0002173 a rdf:Property ;
  rdfs:label "ambiguous for taxon"@en ;
  rdfs:comment "S ambiguous_for_taxon T if the class S does not have a clear referent in taxon T. An example would be the class 'manual digit 1', which encompasses a homology hypotheses that is accepted for some species (e.g. human and mouse), but does not have a clear referent in Aves - the referent is dependent on the hypothesis embraced, and also on the ontogenetic stage.  [PHENOSCPAE:asilomar_mtg]" ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002172 .

obo:RO_0002174 a rdf:Property ;
  rdfs:label "dubious for taxon"@en ;
  rdfs:comment "S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002172 .

obo:RO_0002175 a rdf:Property ;
  rdfs:label "present in taxon"@en ;
  rdfs:comment "S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S" ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002172 .

obo:RO_0002178 a rdf:Property ;
  rdfs:label "supplies"@en ;
  rdfs:comment "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002170 .

obo:RO_0002179 a rdf:Property ;
  rdfs:label "drains"@en ;
  rdfs:comment "Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002170 .

obo:RO_0002180 a rdf:Property ;
  rdfs:label "has component"@en ;
  rdfs:comment "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
  rdfs:seeAlso <http://ontologydesignpatterns.org/wiki/Submissions:Componency> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002201 a rdf:Property ;
  rdfs:label "phenotype of"@en ;
  rdfs:comment "inverse of has phenotype" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002203 a rdf:Property ;
  rdfs:label "develops into"@en ;
  rdfs:comment "inverse of develops from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002387 , obo:RO_0002388 , obo:RO_0002286 .

obo:RO_0002208 a rdf:Property ;
  rdfs:label "parasitoid of" ;
  rdfs:comment "A parasite that kills or sterilizes its host" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002209 a rdf:Property ;
  rdfs:label "has parasitoid" ;
  rdfs:comment "inverse of parasitoid of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002445 .

obo:RO_0002210 a rdf:Property ;
  rdfs:label "directly develops into"@en ;
  rdfs:comment "inverse of directly develops from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002203 .

obo:RO_0002212 a rdf:Property ;
  rdfs:label "negatively regulates"@en ;
  rdfs:comment "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002305 , obo:RO_0002211 .

obo:RO_0002213 a rdf:Property ;
  rdfs:label "positively regulates"@en ;
  rdfs:comment "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002304 , obo:RO_0002211 .

obo:RO_0002216 a rdf:Property ;
  rdfs:label "capable of part of"@en ;
  rdfs:comment "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/reflexivity/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002500 , obo:RO_0002328 .

obo:RO_0002217 a rdf:Property ;
  rdfs:label "obsolete actively participates in" ;
  rdfs:comment "OBSOLETE x actively participates in y if and only if x participates in y and x realizes some active role" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002218 a rdf:Property ;
  rdfs:label "obsolete has active participant" ;
  rdfs:comment "OBSOLETE x has participant y if and only if x realizes some active role that inheres in y" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002219 a rdf:Property ;
  rdfs:label "surrounded by"@en ;
  rdfs:comment "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002220 .

obo:RO_0002221 a rdf:Property ;
  rdfs:label "surrounds"@en ;
  rdfs:comment "inverse of surrounded by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002220 .

obo:RO_0002223 a rdf:Property ;
  rdfs:label "starts"@en ;
  rdfs:comment "inverse of starts with" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 , obo:BFO_0000050 .

obo:RO_0002224 a rdf:Property ;
  rdfs:label "starts with"@en ;
  rdfs:comment "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 , obo:BFO_0000051 .

obo:RO_0002225 a rdf:Property ;
  rdfs:label "develops from part of"@en ;
  rdfs:comment "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002202 .

obo:RO_0002227 a rdf:Property ;
  rdfs:label "obligate parasite of" ;
  rdfs:comment "A sub-relation of parasite-of in which the parasite that cannot complete its life cycle without a host." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002228 a rdf:Property ;
  rdfs:label "facultative parasite of" ;
  rdfs:comment "A sub-relations of parasite-of in which the parasite that can complete its life cycle independent of a host." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002229 a rdf:Property ;
  rdfs:label "ends"@en ;
  rdfs:comment "inverse of ends with" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 , obo:BFO_0000050 .

obo:RO_0002230 a rdf:Property ;
  rdfs:label "ends with"@en ;
  rdfs:comment "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 , obo:BFO_0000051 .

obo:RO_0002234 a rdf:Property ;
  rdfs:label "has output"@en ;
  rdfs:comment "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Has_output> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0002235 a rdf:Property ;
  rdfs:label "stem parasite of" ;
  rdfs:comment "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host stem (PO:0009047)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002236 a rdf:Property ;
  rdfs:label "root parasite of" ;
  rdfs:comment "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host root (PO:0009005)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002237 a rdf:Property ;
  rdfs:label "hemiparasite of" ;
  rdfs:comment "A sub-relation of parasite-of in which the parasite is a plant, and the parasite is parasitic under natural conditions and is also photosynthetic to some degree. Hemiparasites may just obtain water and mineral nutrients from the host plant. Many obtain at least part of their organic nutrients from the host as well." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002238 a rdf:Property ;
  rdfs:label "has component participant"@en ;
  rdfs:comment "X 'has component participant' Y means X 'has participant' Y and there is a cardinality constraint that specifies the numbers of Ys." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0002240 a rdf:Property ;
  rdfs:label "has exposure receptor" ;
  rdfs:comment "A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002241 a rdf:Property ;
  rdfs:label "has exposure stressor" ;
  rdfs:comment "A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002309 .

obo:RO_0002242 a rdf:Property ;
  rdfs:label "has exposure route" ;
  rdfs:comment "A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002243 a rdf:Property ;
  rdfs:label "has exposure transport path" ;
  rdfs:comment "A broad relationship between an exposure event or process and the course takes from the source to the target." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002245 a rdf:Property ;
  rdfs:label "over-expressed in" ;
  rdfs:comment "g is over-expressed in t iff g is expressed in t, and the expression level of g is increased relative to some background." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002246 a rdf:Property ;
  rdfs:label "under-expressed in" ;
  rdfs:comment "g is under-expressed in t iff g is expressed in t, and the expression level of g is decreased relative to some background." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002249 a rdf:Property ;
  rdfs:label "active ingredient in" ;
  rdfs:comment "inverse of has active ingredient" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0002252 a rdf:Property ;
  rdfs:label "connecting branch of" ;
  rdfs:comment "b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/2212> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002375 , obo:RO_0002170 .

obo:RO_0002253 a rdf:Property ;
  rdfs:label "has connecting branch" ;
  rdfs:comment "inverse of connecting branch of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002375 .

obo:RO_0002255 a rdf:Property ;
  rdfs:label "developmentally contributes to"@en ;
  rdfs:comment "inverse of has developmental contribution from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002385 , obo:RO_0002286 .

obo:RO_0002257 a rdf:Property ;
  rdfs:label "developmentally induces"@en ;
  rdfs:comment "Inverse of developmentally induced by"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002386 , obo:RO_0002286 .

obo:RO_0002259 a rdf:Property ;
  rdfs:label "defined by inverse" ;
  rdfs:range xsd:string .

obo:RO_0002260 a rdf:Property ;
  rdfs:label "has biological role" ;
  rdfs:comment "c has-biological-role r iff c has-role r and r is a biological role (CHEBI:24432)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000087 .

obo:RO_0002261 a rdf:Property ;
  rdfs:label "has application role" ;
  rdfs:comment "c has-application-role r iff c has-role r and r is an application role (CHEBI:33232)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000087 .

obo:RO_0002262 a rdf:Property ;
  rdfs:label "has chemical role" ;
  rdfs:comment "c has-chemical-role r iff c has-role r and r is a chemical role (CHEBI:51086)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000087 .

obo:RO_0002263 a rdf:Property ;
  rdfs:label "acts upstream of" ;
  rdfs:comment "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." ;
  rdfs:seeAlso <http://wiki.geneontology.org/index.php/Acts_upstream_of> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0002264 a rdf:Property ;
  rdfs:label "acts upstream of or within" ;
  rdfs:comment "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Acts_upstream_of_or_within> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002500 .

obo:RO_0002285 a rdf:Property ;
  rdfs:label "developmentally replaces"@en ;
  rdfs:comment "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002258 .

obo:RO_0002286 a rdf:Property ;
  rdfs:label "developmentally succeeded by"@en ;
  rdfs:comment "Inverse of developmentally preceded by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002384 .

obo:RO_0002287 a rdf:Property ;
  rdfs:label "part of developmental precursor of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002286 .

obo:RO_0002291 a rdf:Property ;
  rdfs:label "ubiquitously expressed in"@en ;
  rdfs:comment "x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002292 a rdf:Property ;
  rdfs:label "expresses"@en ;
  rdfs:comment "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002293 a rdf:Property ;
  rdfs:label "ubiquitously expresses"@en ;
  rdfs:comment "inverse of ubiquiotously expressed in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002292 .

obo:RO_0002296 a rdf:Property ;
  rdfs:label "results in development of"@en ;
  rdfs:comment "p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002297 a rdf:Property ;
  rdfs:label "results in formation of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002295 , obo:RO_0002234 .

obo:RO_0002298 a rdf:Property ;
  rdfs:label "results in morphogenesis of"@en ;
  rdfs:comment "The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002299 a rdf:Property ;
  rdfs:label "results in maturation of"@en ;
  rdfs:comment "The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002300 a rdf:Property ;
  rdfs:label "results in disappearance of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002552 .

obo:RO_0002301 a rdf:Property ;
  rdfs:label "results in developmental regression of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002552 .

obo:RO_0002302 a rdf:Property ;
  rdfs:label "is treated by substance" ;
  rdfs:comment "Inverse of 'is substance that treats'" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002304 a rdf:Property ;
  rdfs:label "causally upstream of, positive effect" ;
  rdfs:comment "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Causally_upstream_of,_positive_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004047 , obo:RO_0002411 .

obo:RO_0002305 a rdf:Property ;
  rdfs:label "causally upstream of, negative effect" ;
  rdfs:comment "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Causally_upstream_of,_negative_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004046 , obo:RO_0002411 .

obo:RO_0002309 a rdf:Property ;
  rdfs:label "has exposure stimulus" ;
  rdfs:comment "A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002312 a rdf:Property ;
  rdfs:label "evolutionary variant of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002320 .

obo:RO_0002313 a rdf:Property ;
  rdfs:label "transports or maintains localization of"@en ;
  rdfs:comment "Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment)  and the outcome of this process is to regulate the localization of c." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002337 .

obo:RO_0002314 a rdf:Property ;
  rdfs:label "characteristic of part of"@en ;
  rdfs:comment "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/reflexivity/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002502 .

obo:RO_0002315 a rdf:Property ;
  rdfs:label "results in acquisition of features of"@en ;
  rdfs:comment "The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity" ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002320 a rdf:Property ;
  rdfs:label "evolutionarily related to"@en ;
  rdfs:comment "A relationship that holds via some environmental process" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002321 a rdf:Property ;
  rdfs:label "ecologically related to"@en ;
  rdfs:comment "A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002322 a rdf:Property ;
  rdfs:label "confers advantage in"@en ;
  rdfs:range obo:ENVO_01000254 ;
  rdfs:subPropertyOf obo:RO_0002321 .

obo:RO_0002323 a rdf:Property ;
  rdfs:label "mereotopologically related to"@en ;
  rdfs:comment "A mereological relationship or a topological relationship" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002324 a rdf:Property ;
  rdfs:label "developmentally related to"@en ;
  rdfs:comment "A relationship that holds between entities participating in some developmental process (GO:0032502)" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002326 a rdf:Property ;
  rdfs:label "contributes to"@en ;
  rdfs:seeAlso <https://wiki.geneontology.org/Contributes_to> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002329 , obo:RO_0002216 .

obo:RO_0002327 a rdf:Property ;
  rdfs:label "enables"@en ;
  rdfs:comment "c enables p iff c is capable of p and c acts to execute p." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Enables> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002215 .

obo:RO_0002328 a rdf:Property ;
  rdfs:label "functionally related to"@en ;
  rdfs:comment "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002329 a rdf:Property ;
  rdfs:label "part of structure that is capable of"@en ;
  rdfs:comment "this relation holds between c and p when c is part of some c', and c' is capable of p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 .

obo:RO_0002331 a rdf:Property ;
  rdfs:label "involved in"@en ;
  rdfs:comment "c involved_in p if and only if c enables some process p', and p' is part of p" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Involved_in> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002431 , obo:RO_0000056 .

obo:RO_0002333 a rdf:Property ;
  rdfs:label "enabled by"@en ;
  rdfs:comment "inverse of enables" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Enabled_by> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000057 .

obo:RO_0002335 a rdf:Property ;
  rdfs:label "negatively regulated by"@en ;
  rdfs:comment "inverse of negatively regulates" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002336 a rdf:Property ;
  rdfs:label "positively regulated by"@en ;
  rdfs:comment "inverse of positively regulates" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002338 a rdf:Property ;
  rdfs:label "has target start location"@en ;
  rdfs:comment "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002344 .

obo:RO_0002339 a rdf:Property ;
  rdfs:label "has target end location"@en ;
  rdfs:comment "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002344 .

obo:RO_0002340 a rdf:Property ;
  rdfs:label "imports"@en ;
  rdfs:comment "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002020 .

obo:RO_0002341 a rdf:Property ;
  rdfs:label "results in transport along"@en ;
  rdfs:comment "Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l " ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002337 .

obo:RO_0002342 a rdf:Property ;
  rdfs:label "results in transport across"@en ;
  rdfs:comment "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002344 , obo:RO_0002021 .

obo:RO_0002343 a rdf:Property ;
  rdfs:label "results in growth of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002344 a rdf:Property ;
  rdfs:label "results in transport to from or in"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002337 .

obo:RO_0002345 a rdf:Property ;
  rdfs:label "exports"@en ;
  rdfs:comment "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the end location of c is part of the region that surrounds s." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002020 .

obo:RO_0002348 a rdf:Property ;
  rdfs:label "results in commitment to"@en ;
  rdfs:comment "p 'results in commitment to' c if and only if p is a developmental process and c is a cell and p results in the state of c changing such that is can only develop into a single cell type." ;
  rdfs:range obo:CL_0000000 ;
  rdfs:subPropertyOf obo:RO_0002295 .

obo:RO_0002349 a rdf:Property ;
  rdfs:label "results in determination of"@en ;
  rdfs:comment "p 'results in determination of' c if and only if p is a developmental process and c is a cell and p results in the state of c changing to be determined. Once a cell becomes determined, it becomes committed to differentiate down a particular pathway regardless of its environment." ;
  rdfs:range obo:CL_0000000 ;
  rdfs:subPropertyOf obo:RO_0002295 .

obo:RO_0002350 a rdf:Property ;
  rdfs:label "member of"@en ;
  rdfs:comment "is member of is a mereological relation between a item and a collection." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0002351 a rdf:Property ;
  rdfs:label "has member"@en ;
  rdfs:comment "has member is a mereological relation between a collection and an item." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002352 a rdf:Property ;
  rdfs:label "input of"@en ;
  rdfs:comment "inverse of has input" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000056 .

obo:RO_0002353 a rdf:Property ;
  rdfs:label "output of"@en ;
  rdfs:comment "inverse of has output" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000056 .

obo:RO_0002354 a rdf:Property ;
  rdfs:label "formed as result of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002353 .

obo:RO_0002355 a rdf:Property ;
  rdfs:label "results in structural organization of"@en ;
  rdfs:comment "A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002356 a rdf:Property ;
  rdfs:label "results in specification of"@en ;
  rdfs:comment "The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. " ;
  rdfs:range obo:CL_0000000 ;
  rdfs:subPropertyOf obo:RO_0002295 .

obo:RO_0002357 a rdf:Property ;
  rdfs:label "results in developmental induction of"@en ;
  rdfs:comment "p results in developmental induction of c if and only if p is a collection of cell-cell signaling processes that signal to a neighbouring tissue that is the precursor of the mature c, where the signaling results in the commitment to cell types necessary for the formation of c." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002295 .

obo:RO_0002360 a rdf:Property ;
  rdfs:label "has dendrite location"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002371 a rdf:Property ;
  rdfs:label "attached to"@en ;
  rdfs:comment "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002177 , obo:RO_0002170 .

obo:RO_0002374 a rdf:Property ;
  rdfs:label "derived from ancestral fusion of"@en ;
  rdfs:comment "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002156 .

obo:RO_0002376 a rdf:Property ;
  rdfs:label "tributary of"@en ;
  rdfs:comment "x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein." ;
  rdfs:seeAlso <http://dbpedia.org/ontology/drainsTo> , <http://en.wikipedia.org/wiki/Tributary> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002375 , obo:RO_0002170 .

obo:RO_0002377 a rdf:Property ;
  rdfs:label "distributary of"@en ;
  rdfs:comment "x distributary_of y if and only if x is capable of channeling the flow of a substance to y, where y channels less of the substance than x" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002375 , obo:RO_0002170 .

obo:RO_0002378 a rdf:Property ;
  rdfs:label "anabranch of"@en ;
  rdfs:comment "x anabranch_of y if x is a distributary of y (i.e. it channels a from a larger flow from y) and x ultimately channels the flow back into y." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002377 .

obo:RO_0002379 a rdf:Property ;
  rdfs:label "spatially coextensive with"@en ;
  rdfs:comment "x spatially_coextensive_with y if and inly if x and y have the same location" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002380 a rdf:Property ;
  rdfs:label "branching part of"@en ;
  rdfs:comment "x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y" ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/2212> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002375 , obo:BFO_0000050 .

obo:RO_0002381 a rdf:Property ;
  rdfs:label "main stem of"@en ;
  rdfs:comment "x main_stem_of y if y is a branching structure and x is a channel that traces a linear path through y, such that x has higher capacity than any other such path." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/2212> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002375 , obo:BFO_0000050 .

obo:RO_0002382 a rdf:Property ;
  rdfs:label "proper distributary of"@en ;
  rdfs:comment "x proper_distributary_of y iff x distributary_of y and x does not flow back into y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002377 .

obo:RO_0002383 a rdf:Property ;
  rdfs:label "proper tributary of"@en ;
  rdfs:comment "x proper_tributary_of y iff x tributary_of y and x does not originate from y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002376 .

obo:RO_0002385 a rdf:Property ;
  rdfs:label "has potential to developmentally contribute to"@en ;
  rdfs:comment "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002384 .

obo:RO_0002386 a rdf:Property ;
  rdfs:label "has potential to developmentally induce"@en ;
  rdfs:comment "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002384 .

obo:RO_0002387 a rdf:Property ;
  rdfs:label "has potential to develop into"@en ;
  rdfs:comment "x has the potential to develop into y iff x develops into y or if x is capable of developing into y"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002384 .

obo:RO_0002388 a rdf:Property ;
  rdfs:label "has potential to directly develop into"@en ;
  rdfs:comment "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002387 .

obo:RO_0002400 a rdf:Property ;
  rdfs:label "has direct input"@en ;
  rdfs:comment "p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002233 .

obo:RO_0002401 a rdf:Property ;
  rdfs:label "obsolete has indirect input" ;
  rdfs:comment """Likely to be obsoleted. See:
https://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit""" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002402 a rdf:Property ;
  rdfs:label "obsolete has direct output" ;
  rdfs:comment "p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. " ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002403 a rdf:Property ;
  rdfs:label "obsolete has indirect output" ;
  rdfs:comment """Likely to be obsoleted. See:
https://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit""" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002404 a rdf:Property ;
  rdfs:label "causally downstream of"@en ;
  rdfs:comment "inverse of upstream of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002427 , obo:BFO_0000062 .

obo:RO_0002405 a rdf:Property ;
  rdfs:label "immediately causally downstream of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002404 , obo:RO_0002087 .

obo:RO_0002406 a rdf:Property ;
  rdfs:label "obsolete directly activates"@en ;
  rdfs:comment "This term was obsoleted because it has the same meaning as 'directly positively regulates'." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002407 a rdf:Property ;
  rdfs:label "indirectly positively regulates"@en ;
  rdfs:comment "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Indirectly_positively_regulates> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012012 , obo:RO_0002213 .

obo:RO_0002408 a rdf:Property ;
  rdfs:label "obsolete directly inhibits"@en ;
  rdfs:comment "This term was obsoleted because it has the same meaning as 'directly negatively regulates'." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002409 a rdf:Property ;
  rdfs:label "indirectly negatively regulates"@en ;
  rdfs:comment "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Indirectly_negatively_regulates> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012012 , obo:RO_0002212 .

obo:RO_0002410 a rdf:Property ;
  rdfs:label "causally related to"@en ;
  rdfs:comment "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002411 a rdf:Property ;
  rdfs:label "causally upstream of"@en ;
  rdfs:comment "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002418 , obo:BFO_0000063 .

obo:RO_0002412 a rdf:Property ;
  rdfs:label "immediately causally upstream of"@en ;
  rdfs:comment "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002411 , obo:RO_0002090 .

obo:RO_0002413 a rdf:Property ;
  rdfs:label "provides input for"@en ;
  rdfs:comment "p provides input for q iff p is immediately causally upstream of q, and there exists some c such that p has_output c and q has_input c." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Provides_input_for> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002414 , obo:RO_0002412 .

obo:RO_0002416 a rdf:Property ;
  rdfs:label "logical macro assertion"@en ;
  rdfs:comment "An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/shortcut-relations/> ;
  rdfs:range xsd:string .

obo:RO_0002418 a rdf:Property ;
  rdfs:label "causally upstream of or within" ;
  rdfs:comment "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002501 .

obo:RO_0002419 a rdf:Property ;
  rdfs:label "annotation property cardinality"@en ;
  rdfs:comment "An assertion that holds between an OWL Annotation Property P and a non-negative integer N, with the interpretation: for any P(i j) it must be the case that | { k : P(i k) } | = N." ;
  rdfs:range xsd:nonNegativeInteger ;
  rdfs:subPropertyOf obo:RO_0002423 .

obo:RO_0002420 a rdf:Property ;
  rdfs:label "logical macro assertion on a class"@en ;
  rdfs:comment "A logical macro assertion whose domain is an IRI for a class" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002416 .

obo:RO_0002421 a rdf:Property ;
  rdfs:label "logical macro assertion on a property"@en ;
  rdfs:comment "A logical macro assertion whose domain is an IRI for a property" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002416 .

obo:RO_0002422 a rdf:Property ;
  rdfs:label "logical macro assertion on an object property"@en ;
  rdfs:comment "Used to annotate object properties to describe a logical meta-property or characteristic of the object property." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002421 .

obo:RO_0002423 a rdf:Property ;
  rdfs:label "logical macro assertion on an annotation property"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002421 .

obo:RO_0002424 a rdf:Property ;
  rdfs:label "differs in"@en ;
  rdfs:comment "This is an exploratory relation" ;
  rdfs:seeAlso <https://code.google.com/p/phenotype-ontologies/w/edit/PhenotypeModelCompetencyQuestions> ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002425 a rdf:Property ;
  rdfs:label "differs in attribute of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002424 .

obo:RO_0002426 a rdf:Property ;
  rdfs:label "differs in attribute"@en ;
  rdfs:range obo:BFO_0000020 ;
  rdfs:subPropertyOf obo:RO_0002424 .

obo:RO_0002427 a rdf:Property ;
  rdfs:label "causally downstream of or within" ;
  rdfs:comment "inverse of causally upstream of or within" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002501 .

obo:RO_0002428 a rdf:Property ;
  rdfs:label "involved in regulation of" ;
  rdfs:comment "c involved in regulation of p if c is involved in some p' and p' regulates some p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002431 , obo:RO_0002263 .

obo:RO_0002429 a rdf:Property ;
  rdfs:label "involved in positive regulation of" ;
  rdfs:comment "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002428 .

obo:RO_0002430 a rdf:Property ;
  rdfs:label "involved in negative regulation of" ;
  rdfs:comment "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002428 .

obo:RO_0002431 a rdf:Property ;
  rdfs:label "involved in or involved in regulation of" ;
  rdfs:comment "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0002500 , obo:RO_0002264 .

obo:RO_0002432 a rdf:Property ;
  rdfs:label "is active in" ;
  rdfs:comment "c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Is_active_in> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0002131 .

obo:RO_0002433 a rdf:Property ;
  rdfs:label "contributes to morphology of" ;
  rdfs:comment "p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002435 a rdf:Property ;
  rdfs:label "genetically interacts with" ;
  rdfs:seeAlso obo:ECO_0000316 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002434 .

obo:RO_0002436 a rdf:Property ;
  rdfs:label "molecularly interacts with" ;
  rdfs:comment "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." ;
  rdfs:seeAlso obo:ECO_0000353 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002434 .

obo:RO_0002438 a rdf:Property ;
  rdfs:label "trophically interacts with" ;
  rdfs:comment "An interaction relationship in which the partners are related via a feeding relationship." ;
  rdfs:seeAlso <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002439 a rdf:Property ;
  rdfs:label "preys on" ;
  rdfs:comment "An interaction relationship involving a predation process, where the subject kills the target in order to eat it or to feed to siblings, offspring or group members" ;
  rdfs:seeAlso <http://eol.org/schema/terms/preysUpon> , <http://www.inaturalist.org/observations/2942824> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002438 .

obo:RO_0002440 a rdf:Property ;
  rdfs:label "symbiotically interacts with" ;
  rdfs:comment "A biotic interaction in which the two organisms live together in more or less intimate association." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002441 a rdf:Property ;
  rdfs:label "commensually interacts with" ;
  rdfs:comment "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected (GO)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002440 .

obo:RO_0002442 a rdf:Property ;
  rdfs:label "mutualistically interacts with" ;
  rdfs:comment "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other (GO)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002440 .

obo:RO_0002443 a rdf:Property ;
  rdfs:label "interacts with via parasite-host interaction" ;
  rdfs:comment "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms (GO)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002440 .

obo:RO_0002444 a rdf:Property ;
  rdfs:label "parasite of" ;
  rdfs:seeAlso <http://eol.org/schema/terms/parasitizes> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002454 , obo:RO_0002443 .

obo:RO_0002445 a rdf:Property ;
  rdfs:label "parasitized by" ;
  rdfs:seeAlso <http://eol.org/schema/terms/hasParasite> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002453 , obo:RO_0002443 .

obo:RO_0002446 a rdf:Property ;
  rdfs:label "participates in a abiotic-biotic interaction with" ;
  rdfs:comment "A biotic interaction relationship in which one partner is an organism and the other partner is inorganic. For example, the relationship between a sponge and the substrate to which is it anchored." ;
  rdfs:seeAlso <http://dx.doi.org/10.1016/j.ecoinf.2014.08.005> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002437 .

obo:RO_0002447 a rdf:Property ;
  rdfs:label "phosphorylates" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002436 .

obo:RO_0002451 a rdf:Property ;
  rdfs:label "transmitted by" ;
  rdfs:comment "A relationship that holds between a disease and organism" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002321 .

obo:RO_0002453 a rdf:Property ;
  rdfs:label "host of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002440 .

obo:RO_0002454 a rdf:Property ;
  rdfs:label "has host" ;
  rdfs:comment "X 'has host' y if and only if: x is an organism, y is an organism, and x can live on the surface of or within the body of y" ;
  rdfs:seeAlso <http://eol.org/schema/terms/hasHost> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002440 .

obo:RO_0002455 a rdf:Property ;
  rdfs:label "pollinates" ;
  rdfs:seeAlso <http://eol.org/schema/terms/pollinates> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002442 .

obo:RO_0002456 a rdf:Property ;
  rdfs:label "pollinated by" ;
  rdfs:seeAlso <http://eol.org/schema/terms/hasPollinator> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002442 .

obo:RO_0002457 a rdf:Property ;
  rdfs:label "acquires nutrients from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002438 .

obo:RO_0002458 a rdf:Property ;
  rdfs:label "preyed upon by" ;
  rdfs:comment "inverse of preys on" ;
  rdfs:seeAlso <http://eol.org/schema/terms/HasPredator> , <http://polytraits.lifewatchgreece.eu/terms/PRED> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002438 .

obo:RO_0002459 a rdf:Property ;
  rdfs:label "is vector for" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002460 a rdf:Property ;
  rdfs:label "has vector" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002461 a rdf:Property ;
  rdfs:label "partner in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:RO_0002462 a rdf:Property ;
  rdfs:label "subject participant in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002461 .

obo:RO_0002463 a rdf:Property ;
  rdfs:label "target participant in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002461 .

obo:RO_0002464 a rdf:Property ;
  rdfs:label "helper property (not for use in curation)" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002465 a rdf:Property ;
  rdfs:label "is symbiosis" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002563 .

obo:RO_0002466 a rdf:Property ;
  rdfs:label "is commensalism" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002465 .

obo:RO_0002467 a rdf:Property ;
  rdfs:label "is mutualism" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002465 .

obo:RO_0002468 a rdf:Property ;
  rdfs:label "is parasitism" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002465 .

obo:RO_0002469 a rdf:Property ;
  rdfs:label "provides nutrients for" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002438 .

obo:RO_0002470 a rdf:Property ;
  rdfs:label "eats" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002438 .

obo:RO_0002471 a rdf:Property ;
  rdfs:label "is eaten by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002438 .

obo:RO_0002472 a rdf:Property ;
  rdfs:label "is evidence for" ;
  rdfs:comment """A relationship between a piece of evidence a and some entity b, where b is  an information content entity, material entity or process, and 
the a supports either the existence of b, or the truth value of b.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002616 .

obo:RO_0002474 a rdf:Property ;
  rdfs:label "dispositional interpretation" ;
  rdfs:comment "An assertion that holds between an OWL Object Property and a dispositional interpretation that elucidates how OWL Class Axioms or OWL Individuals that use this property are to be interpreted in a dispositional context. For example,  A binds B may be interpreted as A have a mutual disposition that is realized by binding to the other one." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002475 a rdf:Property ;
  rdfs:label "has no connections with" ;
  rdfs:comment "A is has_no_connections_with B if there are no parts of A or B that have a connection with the other." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002420 .

obo:RO_0002477 a rdf:Property ;
  rdfs:label "child nucleus of in hermaphrodite" ;
  rdfs:comment "A child nucleus relationship in which the cells are part of a hermaphroditic organism" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002476 .

obo:RO_0002478 a rdf:Property ;
  rdfs:label "child nucleus of in male" ;
  rdfs:comment "A child nucleus relationship in which the cells are part of a male organism" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002476 .

obo:RO_0002480 a rdf:Property ;
  rdfs:label "ubiquitinates" ;
  rdfs:comment "An interaction relation between x and y in which x catalyzes a reaction in which one or more ubiquitin groups are added to y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002436 .

obo:RO_0002481 a rdf:Property ;
  rdfs:label "is kinase activity" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002564 .

obo:RO_0002482 a rdf:Property ;
  rdfs:label "is ubiquitination" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002564 .

obo:RO_0002483 a rdf:Property ;
  rdfs:label "inherited annotation property" ;
  rdfs:range xsd:string .

obo:RO_0002484 a rdf:Property ;
  rdfs:label "curator guidance link" ;
  rdfs:comment "Connects an ontology entity (class, property, etc) to a URL from which curator guidance can be obtained. This assertion is inherited in the same manner as functional annotations (e.g. for GO, over SubClassOf and part_of)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002483 .

obo:RO_0002485 a rdf:Property ;
  rdfs:label "receives input from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002170 .

obo:RO_0002486 a rdf:Property ;
  rdfs:label "sends output to" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002170 .

obo:RO_0002488 a rdf:Property ;
  rdfs:label "existence starts during" ;
  rdfs:comment "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002496 , obo:RO_0002490 .

obo:RO_0002489 a rdf:Property ;
  rdfs:label "existence starts with" ;
  rdfs:comment "x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002488 .

obo:RO_0002490 a rdf:Property ;
  rdfs:label "existence overlaps" ;
  rdfs:comment "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002487 .

obo:RO_0002491 a rdf:Property ;
  rdfs:label "existence starts and ends during" ;
  rdfs:comment "x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002492 , obo:RO_0002488 .

obo:RO_0002492 a rdf:Property ;
  rdfs:label "existence ends during" ;
  rdfs:comment "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002497 , obo:RO_0002490 .

obo:RO_0002493 a rdf:Property ;
  rdfs:label "existence ends with" ;
  rdfs:comment "x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002492 .

obo:RO_0002494 a rdf:Property ;
  rdfs:label "transformation of" ;
  rdfs:comment "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002202 .

obo:RO_0002495 a rdf:Property ;
  rdfs:label "immediate transformation of" ;
  rdfs:comment "x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002494 , obo:RO_0002207 .

obo:RO_0002496 a rdf:Property ;
  rdfs:label "existence starts during or after" ;
  rdfs:comment "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002487 .

obo:RO_0002497 a rdf:Property ;
  rdfs:label "existence ends during or before" ;
  rdfs:comment "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002487 .

obo:RO_0002500 a rdf:Property ;
  rdfs:label "causal agent in process" ;
  rdfs:comment "A relationship between a material entity and a process where the material entity has some causal role that influences the process" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002595 .

obo:RO_0002502 a rdf:Property ;
  rdfs:label "depends on" ;
  rdfs:seeAlso obo:BFO_0000169 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002503 a rdf:Property ;
  rdfs:label "towards" ;
  rdfs:comment "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002502 .

obo:RO_0002504 a rdf:Property ;
  rdfs:label "always present in taxon" ;
  rdfs:comment "S always_present_in_taxon T if every fully formed member of taxon T has part some S, or is an instance of S" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002175 .

obo:RO_0002505 a rdf:Property ;
  rdfs:label "has intermediate" ;
  rdfs:comment "p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0002508 a rdf:Property ;
  rdfs:label "determines" ;
  rdfs:comment "inverse of determined by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002566 .

obo:RO_0002511 a rdf:Property ;
  rdfs:label "transcribed to" ;
  rdfs:comment "inverse of transcribed from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002515 a rdf:Property ;
  rdfs:label "sequentially adjacent to" ;
  rdfs:comment "x is sequentially adjacent to y iff x and y do not overlap and if there are no base units intervening between x and y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002527 .

obo:RO_0002516 a rdf:Property ;
  rdfs:label "has start sequence" ;
  rdfs:comment "x has start sequence y if the start of x is identical to the start of y, and x has y as a subsequence" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002524 .

obo:RO_0002517 a rdf:Property ;
  rdfs:label "is start sequence of" ;
  rdfs:comment "inverse of has start sequence" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002525 .

obo:RO_0002518 a rdf:Property ;
  rdfs:label "has end sequence" ;
  rdfs:comment "x has end sequence y if the end of x is identical to the end of y, and x has y as a subsequence" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002524 .

obo:RO_0002519 a rdf:Property ;
  rdfs:label "is end sequence of" ;
  rdfs:comment "inverse of has end sequence" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002525 .

obo:RO_0002520 a rdf:Property ;
  rdfs:label "is consecutive sequence of" ;
  rdfs:comment "x is a consecutive sequence of y iff x has subsequence y, and all the parts of x are made of zero or more repetitions of y or sequences as the same type as y." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002524 .

obo:RO_0002521 a rdf:Property ;
  rdfs:label "is sequentially aligned with" ;
  rdfs:comment "x is sequentially aligned with if a significant portion bases of x and y correspond in terms of their base type and their relative ordering" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002514 .

obo:RO_0002522 a rdf:Property ;
  rdfs:label "bounds sequence of" ;
  rdfs:comment "x bounds the sequence of y iff the upstream-most part of x is upstream of or coincident with the upstream-most part of y, and the downstream-most part of x is downstream of or coincident with the downstream-most part of y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002514 .

obo:RO_0002523 a rdf:Property ;
  rdfs:label "is bound by sequence of" ;
  rdfs:comment "inverse of bounds sequence of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002514 .

obo:RO_0002525 a rdf:Property ;
  rdfs:label "is subsequence of" ;
  rdfs:comment "inverse of has subsequence" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002523 , obo:RO_0002526 , obo:BFO_0000050 .

obo:RO_0002526 a rdf:Property ;
  rdfs:label "overlaps sequence of" ;
  rdfs:comment "x overlaps the sequence of y if and only if x has a subsequence z and z is a subsequence of y." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002514 , obo:RO_0002131 .

obo:RO_0002527 a rdf:Property ;
  rdfs:label "does not overlap sequence of" ;
  rdfs:comment "x does not overlap the sequence of y if and only if there is no z such that x has a subsequence z and z is a subsequence of y." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002514 .

obo:RO_0002528 a rdf:Property ;
  rdfs:label "is upstream of sequence of" ;
  rdfs:comment "inverse of downstream of sequence of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002527 .

obo:RO_0002529 a rdf:Property ;
  rdfs:label "is downstream of sequence of" ;
  rdfs:comment "x is downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, or (2) x and y are sequence units, and x is either immediately downstream of y, or transitively downstream of y." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002527 .

obo:RO_0002530 a rdf:Property ;
  rdfs:label "is immediately downstream of sequence of" ;
  rdfs:comment "x is immediately downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, and x is sequentially adjacent to y, or (2) x and y are sequence units, in which case the immediately downstream relation is primitive and defined by context: for DNA bases, y would be adjacent and 5' to y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002529 , obo:RO_0002515 .

obo:RO_0002531 a rdf:Property ;
  rdfs:label "is immediately upstream of sequence of" ;
  rdfs:comment "inverse of immediately downstream of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002528 , obo:RO_0002515 .

obo:RO_0002535 a rdf:Property ;
  rdfs:label "temporal logical macro assertion on a class" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002420 .

obo:RO_0002536 a rdf:Property ;
  rdfs:label "measurement property has unit" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002423 .

obo:RO_0002537 a rdf:Property ;
  rdfs:label "has start time value" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002535 .

obo:RO_0002538 a rdf:Property ;
  rdfs:label "has end time value" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002535 .

obo:RO_0002539 a rdf:Property ;
  rdfs:label "start, days post fertilization" ;
  rdfs:comment "Count of number of days intervening between the start of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 0 for this property." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002537 .

obo:RO_0002540 a rdf:Property ;
  rdfs:label "end, days post fertilization" ;
  rdfs:comment "Count of number of days intervening between the end of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 1 for this property." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002538 .

obo:RO_0002541 a rdf:Property ;
  rdfs:label "start, years post birth" ;
  rdfs:comment "Count of number of years intervening between the start of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 0 for this property, and the period during which the child is one year old has the value 1." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002537 .

obo:RO_0002542 a rdf:Property ;
  rdfs:label "end, years post birth" ;
  rdfs:comment "Count of number of years intervening between the end of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 1 for this property, and the period during which the child is one year old has the value 2" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002538 .

obo:RO_0002543 a rdf:Property ;
  rdfs:label "start, months post birth" ;
  rdfs:comment "Count of number of months intervening between the start of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 0 for this property, and the period during which the child is one month old has the value 1." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002537 .

obo:RO_0002544 a rdf:Property ;
  rdfs:label "end, months post birth" ;
  rdfs:comment "Count of number of months intervening between the end of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 1 for this property, and the period during which the child is one month old has the value 2" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002538 .

obo:RO_0002545 a rdf:Property ;
  rdfs:label "month of gestation" ;
  rdfs:comment "Defines the start and end of a stage with a duration of 1 month, relative to either the time of fertilization or last menstrual period of the mother (to be clarified), counting from one, in terms of a reference model. Thus if month_of_gestation=3, then the stage is 2 month in." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002535 .

obo:RO_0002546 a rdf:Property ;
  rdfs:label "has developmental stage marker" ;
  rdfs:comment "A relationship between a stage class and an anatomical structure or developmental process class, in which the stage is characterized by the appearance of the structure or the occurrence of the biological process" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002535 .

obo:RO_0002547 a rdf:Property ;
  rdfs:label "start, days post coitum" ;
  rdfs:comment "Count of number of days intervening between the start of the stage and the time of coitum." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002537 .

obo:RO_0002548 a rdf:Property ;
  rdfs:label "end, days post coitum" ;
  rdfs:comment "Count of number of days intervening between the end of the stage and the time of coitum." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002538 .

obo:RO_0002549 a rdf:Property ;
  rdfs:label "start, weeks post birth" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002537 .

obo:RO_0002550 a rdf:Property ;
  rdfs:label "end, weeks post birth" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/temporal-durations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002538 .

obo:RO_0002552 a rdf:Property ;
  rdfs:label "results in ending of" ;
  rdfs:comment "p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002553 a rdf:Property ;
  rdfs:label "hyperparasite of" ;
  rdfs:comment "x is a hyperparasite of y iff x is a parasite of a parasite of the target organism y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002454 .

obo:RO_0002554 a rdf:Property ;
  rdfs:label "hyperparasitized by" ;
  rdfs:comment "inverse of hyperparasite of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002453 .

obo:RO_0002555 a rdf:Property ;
  rdfs:label "allelopath of" ;
  rdfs:seeAlso <http://eol.org/schema/terms/allelopathyYes> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002556 a rdf:Property ;
  rdfs:label "pathogen of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002454 .

obo:RO_0002557 a rdf:Property ;
  rdfs:label "has pathogen" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002453 .

obo:RO_0002558 a rdf:Property ;
  rdfs:label "has evidence" ;
  rdfs:comment "inverse of is evidence for" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002616 .

obo:RO_0002559 a rdf:Property ;
  rdfs:label "causally influenced by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002506 .

obo:RO_0002560 a rdf:Property ;
  rdfs:label "is asymmetric relational form of process class" ;
  rdfs:comment "If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) <-> exists p : Pr(p), x subject-partner-in p, y object-partner-in p" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/interaction-relations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002562 .

obo:RO_0002561 a rdf:Property ;
  rdfs:label "is symmetric relational form of process class" ;
  rdfs:comment "If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) <-> exists p : Pr(p), x partner-in p, y partner-in p" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/interaction-relations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002562 .

obo:RO_0002562 a rdf:Property ;
  rdfs:label "is relational form of process class" ;
  rdfs:comment "R is the relational form of a process if and only if either (1) R is the symmetric relational form of a process or (2) R is the asymmetric relational form of a process" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/interaction-relations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002594 .

obo:RO_0002563 a rdf:Property ;
  rdfs:label "interaction relation helper property" ;
  rdfs:seeAlso <http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29> , <http://purl.obolibrary.org/obo/ro/docs/interaction-relations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002464 .

obo:RO_0002564 a rdf:Property ;
  rdfs:label "molecular interaction relation helper property" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002563 .

obo:RO_0002565 a rdf:Property ;
  rdfs:label "results in movement of" ;
  rdfs:comment "Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 .

obo:RO_0002568 a rdf:Property ;
  rdfs:label "has muscle antagonist" ;
  rdfs:comment "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002567 .

obo:RO_0002569 a rdf:Property ;
  rdfs:label "has branching part" ;
  rdfs:comment "inverse of branching part of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002375 , obo:BFO_0000051 .

obo:RO_0002571 a rdf:Property ;
  rdfs:label "lumen of" ;
  rdfs:comment "x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull." ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0002575 a rdf:Property ;
  rdfs:label "is direct form of" ;
  rdfs:comment "relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/direct-and-indirect-relations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002578 a rdf:Property ;
  rdfs:label "directly regulates" ;
  rdfs:comment "p directly regulates q iff p is immediately causally upstream of q and p regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002412 , obo:RO_0002211 .

obo:RO_0002579 a rdf:Property ;
  rdfs:label "is indirect form of" ;
  rdfs:comment "relation p is the indirect form of relation q iff p is a subPropertyOf q, and there exists some p' such that p' is the direct form of q, p' o p' -> p, and forall x,y : x q y -> either (1) x p y or (2) x p' y" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/direct-and-indirect-relations/> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002580 a rdf:Property ;
  rdfs:label "logical macro assertion on an axiom" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002416 .

obo:RO_0002581 a rdf:Property ;
  rdfs:label "is a defining property chain axiom" ;
  rdfs:comment "If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002580 .

obo:RO_0002582 a rdf:Property ;
  rdfs:label "is a defining property chain axiom where second argument is reflexive" ;
  rdfs:comment "If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002581 .

obo:RO_0002583 a rdf:Property ;
  rdfs:label "existence starts at end of" ;
  rdfs:comment "holds between x and y if and only if the time point at which x starts is equivalent to the time point at which y ends. Formally: iff α(x) = ω(y)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002496 .

obo:RO_0002584 a rdf:Property ;
  rdfs:label "has part structure that is capable of" ;
  rdfs:comment "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002595 , obo:RO_0002328 .

obo:RO_0002585 a rdf:Property ;
  rdfs:label "results in closure of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 , obo:RO_0002295 .

obo:RO_0002586 a rdf:Property ;
  rdfs:label "results in breakdown of" ;
  rdfs:comment "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002233 .

obo:RO_0002587 a rdf:Property ;
  rdfs:label "results in synthesis of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002297 .

obo:RO_0002588 a rdf:Property ;
  rdfs:label "results in assembly of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002592 , obo:RO_0002297 .

obo:RO_0002589 a rdf:Property ;
  rdfs:label "results in catabolism of" ;
  rdfs:comment "p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002586 .

obo:RO_0002590 a rdf:Property ;
  rdfs:label "results in disassembly of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002592 , obo:RO_0002586 .

obo:RO_0002591 a rdf:Property ;
  rdfs:label "results in remodeling of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002592 , obo:RO_0002233 .

obo:RO_0002592 a rdf:Property ;
  rdfs:label "results in organization of" ;
  rdfs:comment "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 .

obo:RO_0002593 a rdf:Property ;
  rdfs:label "existence ends at start of" ;
  rdfs:comment "holds between x and y if and only if the time point at which x ends is equivalent to the time point at which y starts. Formally: iff ω(x) = α(y)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002497 .

obo:RO_0002594 a rdf:Property ;
  rdfs:label "is relational form of a class" ;
  rdfs:comment "An annotation property that connects an object property to a class, where the object property is derived from or a shortcut property for the class. The exact semantics of this annotation may vary on a case by case basis." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002596 a rdf:Property ;
  rdfs:label "capable of regulating" ;
  rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a regulates p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002500 .

obo:RO_0002597 a rdf:Property ;
  rdfs:label "capable of negatively regulating" ;
  rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002596 .

obo:RO_0002598 a rdf:Property ;
  rdfs:label "capable of positively regulating" ;
  rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002596 .

obo:RO_0002599 a rdf:Property ;
  rdfs:label "capable of inhibiting or preventing pathological process" ;
  rdfs:comment "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002597 .

obo:RO_0002600 a rdf:Property ;
  rdfs:label "capable of upregulating or causing pathological process" ;
  rdfs:comment "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002598 .

obo:RO_0002601 a rdf:Property ;
  rdfs:label "logical macro assertion involving identity" ;
  rdfs:comment "A shortcut relationship that holds between two entities based on their identity criteria" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002416 .

obo:RO_0002602 a rdf:Property ;
  rdfs:label "in approximate one to one relationship with" ;
  rdfs:comment "A shortcut relationship between two entities x and y1, such that the intent is that the relationship is functional and inverse function, but there is no guarantee that this property holds." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002601 .

obo:RO_0002603 a rdf:Property ;
  rdfs:label "is approximately equivalent to" ;
  rdfs:comment "x is approximately equivalent to y if it is the case that x is equivalent, identical or near-equivalent to y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002602 .

obo:RO_0002604 a rdf:Property ;
  rdfs:label "is opposite of" ;
  rdfs:comment "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002602 .

obo:RO_0002605 a rdf:Property ;
  rdfs:label "is indistinguishable from" ;
  rdfs:comment "x is indistinguishable from y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002603 .

obo:RO_0002606 a rdf:Property ;
  rdfs:label "is substance that treats" ;
  rdfs:comment "c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d." ;
  rdfs:seeAlso <https://code.google.com/p/obo-relations/issues/detail?id=46> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002599 .

obo:RO_0002607 a rdf:Property ;
  rdfs:label "is marker for" ;
  rdfs:comment "c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002610 .

obo:RO_0002608 a rdf:Property ;
  rdfs:label "process has causal agent" ;
  rdfs:comment "Inverse of 'causal agent in process'" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002609 a rdf:Property ;
  rdfs:label "obsolete related via dependence to" ;
  rdfs:comment "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002610 a rdf:Property ;
  rdfs:label "correlated with" ;
  rdfs:comment "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002611 a rdf:Property ;
  rdfs:label "evidential logical macro assertion on an axiom" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002580 .

obo:RO_0002612 a rdf:Property ;
  rdfs:label "axiom has evidence" ;
  rdfs:comment "A relationship between a sentence and an instance of a piece of evidence in which the evidence supports the axiom" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002611 .

obo:RO_0002613 a rdf:Property ;
  rdfs:label "axiom contradicted by evidence" ;
  rdfs:comment "A relationship between a sentence and an instance of a piece of evidence in which the evidence contradicts the axiom" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002611 .

obo:RO_0002614 a rdf:Property ;
  rdfs:label "is evidence with support from" ;
  rdfs:comment "A relationship between a piece of evidence and an entity that plays a role in supporting that evidence." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002616 .

obo:RO_0002615 a rdf:Property ;
  rdfs:label "has model" ;
  rdfs:comment "Inverse of is-model-of" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002616 a rdf:Property ;
  rdfs:label "related via evidence or inference to" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002617 a rdf:Property ;
  rdfs:label "is representative IRI for equivalence set" ;
  rdfs:comment "this property relates an IRI to the xsd boolean value \"True\" if the IRI is intended to be the representative IRI for a collection of classes that are mutually equivalent." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002601 .

obo:RO_0002618 a rdf:Property ;
  rdfs:label "visits" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/74> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002619 a rdf:Property ;
  rdfs:label "visited by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002622 a rdf:Property ;
  rdfs:label "visits flowers of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002618 .

obo:RO_0002623 a rdf:Property ;
  rdfs:label "has flowers visited by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002619 .

obo:RO_0002624 a rdf:Property ;
  rdfs:label "lays eggs in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002618 , obo:RO_0002444 .

obo:RO_0002625 a rdf:Property ;
  rdfs:label "has eggs laid in by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002619 , obo:RO_0002445 .

obo:RO_0002626 a rdf:Property ;
  rdfs:label "kills" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002627 a rdf:Property ;
  rdfs:label "is killed by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002574 .

obo:RO_0002629 a rdf:Property ;
  rdfs:label "directly positively regulates" ;
  rdfs:comment "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Directly_positively_regulates> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002578 , obo:RO_0002213 .

obo:RO_0002630 a rdf:Property ;
  rdfs:label "directly negatively regulates" ;
  rdfs:comment "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Directly_negatively_regulates> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002578 , obo:RO_0002212 .

obo:RO_0002632 a rdf:Property ;
  rdfs:label "ectoparasite of" ;
  rdfs:comment "A sub-relation of parasite-of in which the parasite lives on or in the integumental system of the host" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002633 a rdf:Property ;
  rdfs:label "has ectoparasite" ;
  rdfs:comment "inverse of ectoparasite of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002445 .

obo:RO_0002634 a rdf:Property ;
  rdfs:label "endoparasite of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002635 a rdf:Property ;
  rdfs:label "has endoparasite" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002445 .

obo:RO_0002636 a rdf:Property ;
  rdfs:label "mesoparasite of" ;
  rdfs:comment "A sub-relation of parasite-of in which the parasite is partially an endoparasite and partially an ectoparasite" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0002637 a rdf:Property ;
  rdfs:label "has mesoparasite" ;
  rdfs:comment "inverse of mesoparasite of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002445 .

obo:RO_0002638 a rdf:Property ;
  rdfs:label "intercellular endoparasite of" ;
  rdfs:comment "A sub-relation of endoparasite-of in which the parasite inhabits the spaces between host cells." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002634 .

obo:RO_0002639 a rdf:Property ;
  rdfs:label "has intercellular endoparasite" ;
  rdfs:comment "inverse of intercellular endoparasite of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002635 .

obo:RO_0002640 a rdf:Property ;
  rdfs:label "intracellular endoparasite of" ;
  rdfs:comment "A sub-relation of endoparasite-of in which the parasite inhabits host cells." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002634 .

obo:RO_0002641 a rdf:Property ;
  rdfs:label "has intracellular endoparasite" ;
  rdfs:comment "inverse of intracellular endoparasite of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002635 .

obo:RO_0002801 a rdf:Property ;
  rdfs:label "co-roosts with"@en ;
  rdfs:comment "Two or more individuals sharing the same roost site (cave, mine, tree or tree hollow, animal burrow, leaf tent, rock crack, space in man-made structure, etc.). Individuals that are sharing a communal roost may be said to be co-roosting. The roost may be either a day roost where the individuals rest during daytime hours, or a night roost where individuals roost to feed, groom, or rest in between flights and/or foraging bouts.  Communal roosting as thus defined is an umbrella term within which different specialized types -- which are not mutually exclusive -- may be recognized based on taxonomy and the temporal and spatial relationships of the individuals that are co-roosting."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0008506 .

obo:RO_0003301 a rdf:Property ;
  rdfs:label "has role in modeling"@en ;
  rdfs:comment "A relation between a biological, experimental, or computational artifact and an entity it is used to study, in virtue of its replicating or approximating features of the studied entity." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0003302 a rdf:Property ;
  rdfs:label "causes or contributes to condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0003303 a rdf:Property ;
  rdfs:label "causes condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0003304 a rdf:Property ;
  rdfs:label "contributes to condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0003305 a rdf:Property ;
  rdfs:label "contributes to severity of condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0003304 .

obo:RO_0003306 a rdf:Property ;
  rdfs:label "contributes to frequency of condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0003304 .

obo:RO_0003307 a rdf:Property ;
  rdfs:label "ameliorates condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0003305 .

obo:RO_0003308 a rdf:Property ;
  rdfs:label "correlated with condition"@en ;
  rdfs:comment "A relationship between an entity and a condition (phenotype or disease) with which it exhibits a statistical dependence relationship." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002610 .

obo:RO_0003309 a rdf:Property ;
  rdfs:label "exacerbates condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0003305 .

obo:RO_0003310 a rdf:Property ;
  rdfs:label "condition ameliorated by"@en ;
  rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0003311 a rdf:Property ;
  rdfs:label "condition exacerbated by"@en ;
  rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004001 a rdf:Property ;
  rdfs:label "has material basis in gain of function germline mutation in" ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_410295> , <http://www.orpha.net/ORDO/Orphanet_410296> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004002 a rdf:Property ;
  rdfs:label "has material basis in loss of function germline mutation in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004003 a rdf:Property ;
  rdfs:label "has material basis in germline mutation in" ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_317343> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004004 a rdf:Property ;
  rdfs:label "has material basis in somatic mutation in" ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_317344> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004005 a rdf:Property ;
  rdfs:label "has major susceptibility factor" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004006 a rdf:Property ;
  rdfs:label "has partial material basis in germline mutation in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004007 a rdf:Property ;
  rdfs:label "has primary input or output" ;
  rdfs:comment "p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0004008 a rdf:Property ;
  rdfs:label "has primary output" ;
  rdfs:comment "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004007 , obo:RO_0002234 .

obo:RO_0004009 a rdf:Property ;
  rdfs:label "has primary input" ;
  rdfs:comment "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004007 , obo:RO_0002233 .

obo:RO_0004010 a rdf:Property ;
  rdfs:label "is genetic basis for condition" ;
  rdfs:range obo:BFO_0000017 ;
  rdfs:subPropertyOf obo:RO_0004018 .

obo:RO_0004011 a rdf:Property ;
  rdfs:label "is causal gain of function germline mutation of in" ;
  rdfs:comment "Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_410296> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004012 a rdf:Property ;
  rdfs:label "is causal loss of function germline mutation of in" ;
  rdfs:comment "Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_410295> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004013 a rdf:Property ;
  rdfs:label "is causal germline mutation in" ;
  rdfs:comment "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_317343> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004010 , obo:RO_0003303 .

obo:RO_0004014 a rdf:Property ;
  rdfs:label "is causal somatic mutation in" ;
  rdfs:comment "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]." ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_317344> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004010 , obo:RO_0003303 .

obo:RO_0004015 a rdf:Property ;
  rdfs:label "is causal susceptibility factor for" ;
  rdfs:comment "Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition  and that is necessary but not sufficient to develop the condition[modified from orphanet]." ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_317345> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004016 a rdf:Property ;
  rdfs:label "is causal germline mutation partially giving rise to" ;
  rdfs:comment "Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]." ;
  rdfs:seeAlso <http://www.orpha.net/ORDO/Orphanet_317346> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004010 , obo:RO_0003304 .

obo:RO_0004017 a rdf:Property ;
  rdfs:label "realizable has basis in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004018 a rdf:Property ;
  rdfs:label "is basis for realizable" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004020 a rdf:Property ;
  rdfs:label "disease has basis in dysfunction of" ;
  rdfs:comment "A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function." ;
  rdfs:range obo:UBERON_0000465 ;
  rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004021 a rdf:Property ;
  rdfs:label "disease has basis in disruption of" ;
  rdfs:comment "A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process." ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004030 a rdf:Property ;
  rdfs:label "disease arises from alteration in structure" ;
  rdfs:comment "A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. Anatomical structure includes cellular and sub-cellular entities, such as chromosome and organelles." ;
  rdfs:range obo:UBERON_0000061 ;
  rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004031 a rdf:Property ;
  rdfs:label "enables subfunction" ;
  rdfs:comment "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002328 .

obo:RO_0004032 a rdf:Property ;
  rdfs:label "acts upstream of or within, positive effect" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0004033 a rdf:Property ;
  rdfs:label "acts upstream of or within, negative effect" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0004034 a rdf:Property ;
  rdfs:label "acts upstream of, positive effect" ;
  rdfs:comment "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Acts_upstream_of,_positive_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004032 , obo:RO_0002263 .

obo:RO_0004035 a rdf:Property ;
  rdfs:label "acts upstream of, negative effect" ;
  rdfs:comment "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Acts_upstream_of,_negative_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004033 , obo:RO_0002263 .

obo:RO_0004036 a rdf:Property ;
  rdfs:label "nominally disjoint with"@en ;
  rdfs:comment "true if the two properties are disjoint, according to OWL semantics. This should only be used if using a logical axiom introduces a non-simple property violation." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0004046 a rdf:Property ;
  rdfs:label "causally upstream of or within, negative effect" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0004047 a rdf:Property ;
  rdfs:label "causally upstream of or within, positive effect" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0004048 a rdf:Property ;
  rdfs:label "is directional form of" ;
  rdfs:comment "Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be \"+\", \"-\" or \"0\"" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0004049 a rdf:Property ;
  rdfs:label "is positive form of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004048 .

obo:RO_0004050 a rdf:Property ;
  rdfs:label "is negative form of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004048 .

obo:RO_0004096 a rdf:Property ;
  rdfs:label "DEPRECATED inheres in"@en ;
  rdfs:comment "DEPRECATED This relation is similar to but different in important respects to the characteristic-of relation. See comments on that relation for more information." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0004097 a rdf:Property ;
  rdfs:label "DEPRECATED bearer of"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0007000 a rdf:Property ;
  rdfs:label "has driver" ;
  rdfs:comment "A relation between two entities, in which one of the entities is any natural or human-influenced factor that directly or indirectly causes a change in the other entity." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/506> ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0007001 a rdf:Property ;
  rdfs:label "has disease driver" ;
  rdfs:comment "A relation between an entity and a disease of a host, in which the entity is not part of the host itself, and the condition results in pathological processes." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/506> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0007000 .

obo:RO_0008501 a rdf:Property ;
  rdfs:label "epiphyte of" ;
  rdfs:comment "An interaction relationship wherein a plant or algae is living on the outside surface of another plant." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002440 .

obo:RO_0008502 a rdf:Property ;
  rdfs:label "has epiphyte" ;
  rdfs:comment "inverse of epiphyte of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002440 .

obo:RO_0008503 a rdf:Property ;
  rdfs:label "kleptoparasite of" ;
  rdfs:comment "A sub-relation of parasite of in which a parasite steals resources from another organism, usually food or nest material" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002444 .

obo:RO_0008504 a rdf:Property ;
  rdfs:label "kleptoparasitized by" ;
  rdfs:comment "inverse of kleptoparasite of" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002445 .

obo:RO_0008507 a rdf:Property ;
  rdfs:label "lays eggs on" ;
  rdfs:comment "An interaction relationship in which organism a lays eggs on the outside surface of organism b. Organism b is neither helped nor harmed in the process of egg laying or incubation." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002618 .

obo:RO_0008508 a rdf:Property ;
  rdfs:label "has eggs laid on by" ;
  rdfs:comment "inverse of lays eggs on" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002619 .

obo:RO_0009005 a rdf:Property ;
  rdfs:label "has primary substance added"@en ;
  rdfs:comment "'has primary substance added' indicates that an entity has had the given substance added to it in a proportion greater than any other added substance."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0009001 .

obo:RO_0011016 a rdf:Property ;
  rdfs:label "indirectly negatively regulates activity of" ;
  rdfs:comment "The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0011004 .

obo:RO_0011021 a rdf:Property ;
  rdfs:label "directly regulates quantity of" ;
  rdfs:comment "The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0011003 .

obo:RO_0011022 a rdf:Property ;
  rdfs:label "indirectly regulates quantity of" ;
  rdfs:comment "The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0011003 .

obo:RO_0011023 a rdf:Property ;
  rdfs:label "indirectly negatively regulates quantity of" ;
  rdfs:comment "The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0011022 .

obo:RO_0011024 a rdf:Property ;
  rdfs:label "indirectly positively regulates quantity of" ;
  rdfs:comment "The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0011022 .

obo:RO_0012000 a rdf:Property ;
  rdfs:label "has small molecule regulator"@en ;
  rdfs:comment "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0012001 a rdf:Property ;
  rdfs:label "has small molecule activator"@en ;
  rdfs:comment "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012000 .

obo:RO_0012002 a rdf:Property ;
  rdfs:label "has small molecule inhibitor"@en ;
  rdfs:comment "a relation between a process and a continuant, in which the process is inhibited by the small molecule continuant" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012000 .

obo:RO_0012003 a rdf:Property ;
  rdfs:label "acts on population of"@en ;
  rdfs:comment "p acts on population of c iff c' is a collection, has members of type c, and p has participant c" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0012004 a rdf:Property ;
  rdfs:label "is small molecule regulator of"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002596 .

obo:RO_0012005 a rdf:Property ;
  rdfs:label "is small molecule activator of"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Is_small_molecule_activator_of> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012004 , obo:RO_0002598 .

obo:RO_0012006 a rdf:Property ;
  rdfs:label "is small molecule inhibitor of"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is a small molecule that inhibits the process" ;
  rdfs:seeAlso <https://wiki.geneontology.org/Is_small_molecule_inhibitor_of> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012004 , obo:RO_0002597 .

obo:RO_0012007 a rdf:Property ;
  rdfs:label "results in adhesion of"@en ;
  rdfs:comment "The relationship that links anatomical entities with a process that results in the adhesion of two or more entities via the non-covalent interaction of molecules expressed in, located in, and/or adjacent to, those entities." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0040036 .

obo:RO_0012008 a rdf:Property ;
  rdfs:label "results in fusion of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002592 .

obo:RO_0012009 a rdf:Property ;
  rdfs:label "constitutively upstream of"@en ;
  rdfs:comment "p is constitutively upstream of q iff p is causally upstream of q, p is required for execution of q or a part of q, and the execution of p is approximately constant." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Constitutively_upstream_of> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002304 .

obo:RO_0012010 a rdf:Property ;
  rdfs:label "removes input for"@en ;
  rdfs:comment "p removes input for q iff p is causally upstream of q, there exists some c such that p has_input c and q has_input c, p reduces the levels of c, and c is rate limiting for execution of q." ;
  rdfs:seeAlso <https://wiki.geneontology.org/Removes_input_for> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002305 .

obo:RO_0012011 a rdf:Property ;
  rdfs:label "indirectly causally upstream of"@en ;
  rdfs:comment "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002411 .

obo:RO_0012012 a rdf:Property ;
  rdfs:label "indirectly regulates"@en ;
  rdfs:comment "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0012011 , obo:RO_0002211 .

obo:RO_0013001 a rdf:Property ;
  rdfs:label "has synaptic IO in region"@en ;
  rdfs:comment "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002130 .

obo:RO_0013002 a rdf:Property ;
  rdfs:label "receives synaptic input in region"@en ;
  rdfs:comment "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses in that region." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0013001 , obo:RO_0002110 .

obo:RO_0013003 a rdf:Property ;
  rdfs:label "sends synaptic output to region"@en ;
  rdfs:comment "A relationship between a neuron and a region, where the neuron has a functionally relevant number of output synapses in that region." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0013001 , obo:RO_0002113 .

obo:RO_0013004 a rdf:Property ;
  rdfs:label "has synaptic IO throughout"@en ;
  rdfs:comment "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses distributed throughout that region (rather than confined to a subregion)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0013001 .

obo:RO_0013005 a rdf:Property ;
  rdfs:label "receives synaptic input throughout"@en ;
  rdfs:comment "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses distributed throughout that region (rather than confined to a subregion)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0013004 , obo:RO_0013002 .

obo:RO_0013006 a rdf:Property ;
  rdfs:label "sends synaptic output throughout"@en ;
  rdfs:comment "A relationship between a neuron and a region, where the neuron has a functionally relevant number output synapses distributed throughout that region (rather than confined to a subregion)." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0013004 , obo:RO_0013003 .

obo:RO_0013008 a rdf:Property ;
  rdfs:label "receives synaptic input from neuron"@en ;
  rdfs:comment "A relationship between an anatomical structure (including cells) and a neuron that has a functionally relevant number of chemical synapses to it." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002103 .

obo:RO_0013009 a rdf:Property ;
  rdfs:label "sends synaptic output to cell"@en ;
  rdfs:comment "A relationship between a neuron and a cell that it has a functionally relevant number of chemical synapses to." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002120 .

obo:RO_0014001 a rdf:Property ;
  rdfs:label "disease has infectious agent" ;
  rdfs:comment "A relationship between a disease and an infectious agent where the material basis of the disease is an infection with some infectious agent." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0015001 a rdf:Property ;
  rdfs:label "has exemplar data" ;
  rdfs:comment "A relation between a material entity and some data in which the data is taken as exemplifying the material entity." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0015002 a rdf:Property ;
  rdfs:label "exemplar data of" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0015003 a rdf:Property ;
  rdfs:label "subcluster of" ;
  rdfs:comment "A relation between a group and another group it is part of but does not fully constitute." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0015009 a rdf:Property ;
  rdfs:label "similar in magnitude relative to" ;
  rdfs:comment "q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0015010 a rdf:Property ;
  rdfs:label "has relative magnitude" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0015011 a rdf:Property ;
  rdfs:label "has cross section" ;
  rdfs:comment "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0015012 a rdf:Property ;
  rdfs:label "reciprocal of" ;
  rdfs:comment "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0016001 a rdf:Property ;
  rdfs:label "has phenotype or disease" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/478> ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0016002 a rdf:Property ;
  rdfs:label "has disease" ;
  rdfs:comment "A relationship that holds between an organism and a disease. Here a disease is construed broadly as a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/478> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0016001 .

obo:RO_0016004 a rdf:Property ;
  rdfs:label "has exposure medium" ;
  rdfs:comment "X has exposure medium Y if X is an exposure event (process), Y is a material entity, and the stimulus for X is transmitted or carried in Y." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0017001 a rdf:Property ;
  rdfs:label "device utilizes material"@en ;
  rdfs:comment "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0017003 a rdf:Property ;
  rdfs:label "positively correlated with"@en ;
  rdfs:comment "A relation between entities in which one increases or decreases as the other does the same."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002610 .

obo:RO_0017004 a rdf:Property ;
  rdfs:label "negatively correlated with"@en ;
  rdfs:comment "A relation between entities in which one increases as the other decreases."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002610 .

obo:RO_0018001 a rdf:Property ;
  rdfs:label "is myristoyltransferase activity" ;
  rdfs:comment "Helper relation for OWL definition of RO:0018002 myristoylates" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002564 .

obo:RO_0018002 a rdf:Property ;
  rdfs:label "myristoylates" ;
  rdfs:comment "A molecularly-interacts-with relationship between two entities, where the subject catalyzes a myristoylation activity that takes the object as input" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002436 .

obo:RO_0018003 a rdf:Property ;
  rdfs:label "myristoylated by" ;
  rdfs:comment "inverse of myristoylates" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0018027 a rdf:Property ;
  rdfs:label "is agonist of" ;
  rdfs:comment "a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor activates some activity of the receptor" ;
  rdfs:seeAlso <https://www.wikidata.org/wiki/Property:P3772> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002450 .

obo:RO_0018028 a rdf:Property ;
  rdfs:label "is inverse agonist of" ;
  rdfs:comment "a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor inhibits some activity of the receptor to below basal level" ;
  rdfs:seeAlso <https://www.wikidata.org/wiki/Property:P9275> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002449 .

obo:RO_0018029 a rdf:Property ;
  rdfs:label "is antagonist of" ;
  rdfs:comment "a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor reduces some activity of the receptor to basal level" ;
  rdfs:seeAlso <https://www.wikidata.org/wiki/Property:P3773> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002449 .

obo:RO_0018030 a rdf:Property ;
  rdfs:label "chemical relationship" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0018031 a rdf:Property ;
  rdfs:label "is direct conjugate base of" ;
  rdfs:comment "A is a direct conjugate base of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by receiving a particular proton transforms it into B." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/643> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018033 .

obo:RO_0018032 a rdf:Property ;
  rdfs:label "is direct conjugate acid of" ;
  rdfs:comment "A is a direct conjugate acid of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing a particular proton transforms it into B." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/643> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018034 .

obo:RO_0018033 a rdf:Property ;
  rdfs:label "is deprotonated form of" ;
  rdfs:comment """A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.

This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.""" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/643> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0018034 a rdf:Property ;
  rdfs:label "is protonated form of" ;
  rdfs:comment """A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.

This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.""" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/643> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0018035 a rdf:Property ;
  rdfs:label "is matched small molecular pair with" ;
  rdfs:comment """A and B are a matched small molecular pair (MMP) if their chemical structures define by a single, relatively small, well-defined structural modification.

While this is normally called \"matched molecular pair\" in the cheminformatics literaturel, it is labeled as \"matched small molecular pair\" so as to reduce confusion with peptides and other macromolecules, which are also referenced as \"molecules\" in some contexts.

This relationship is symmetric, meaning if A is a MMP with B iff B is a MMP with A.

This relationship is not transitive, meaning that A is a MMP with B and B is a MMP with C, then A is not necessarily an MMP with C.""" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0018036 a rdf:Property ;
  rdfs:label "is tautomer of"@en ;
  rdfs:comment """Two chemicals are tautomers if they can be readily interconverted.

This commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms.""" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/697> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0018037 a rdf:Property ;
  rdfs:label "is substitutent group from"@en ;
  rdfs:comment "Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/697> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0018038 a rdf:Property ;
  rdfs:label "has functional parent"@en ;
  rdfs:comment """Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. 

For example, the relationship between a salt and a freebased compound is a \"has functional parent\" relationship.""" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/697> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0018039 a rdf:Property ;
  rdfs:label "is enantiomer of"@en ;
  rdfs:comment """Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.

A chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers).""" ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/697> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0018040 a rdf:Property ;
  rdfs:label "has parent hydride"@en ;
  rdfs:comment "Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/697> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0018030 .

obo:RO_0019001 a rdf:Property ;
  rdfs:label "positively regulates characteristic" ;
  rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0019000 .

obo:RO_0019002 a rdf:Property ;
  rdfs:label "negatively regulates characteristic" ;
  rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0019000 .

obo:RO_0019501 a rdf:Property ;
  rdfs:label "confers susceptibility to condition" ;
  rdfs:comment "Relates a gene to condition, such that a variation in this gene predisposes to the development of a condition." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0003304 .

obo:RO_0040035 a rdf:Property ;
  rdfs:label "disease relationship" ;
  rdfs:comment "This relation groups  relations between diseases and any other kind of entity." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0040036 a rdf:Property ;
  rdfs:label "results in changes to anatomical or cellular structure" ;
  rdfs:comment "p has anatomical participant c iff p has participant c, and c is an anatomical entity" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0040042 a rdf:Property ;
  rdfs:label "is homeomorphic for" ;
  rdfs:comment "R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C." ;
  rdfs:seeAlso <https://github.com/oborel/obo-relations/issues/164> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_HOM0000001 a rdf:Property ;
  rdfs:label "in homology relationship with" ;
  rdfs:comment "Similarity that results from common evolutionary origin." ;
  rdfs:seeAlso obo:HOM_0000001 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000000 , obo:RO_0002158 .

obo:RO_HOM0000002 a rdf:Property ;
  rdfs:label "in homoplasy relationship with" ;
  rdfs:comment "Similarity that results from independent evolution." ;
  rdfs:seeAlso obo:HOM_0000002 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000000 .

obo:RO_HOM0000003 a rdf:Property ;
  rdfs:label "in homocracy relationship with" ;
  rdfs:comment "Similarity that is characterized by the organization of anatomical structures through the expression of homologous or identical patterning genes." ;
  rdfs:seeAlso obo:HOM_0000003 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000000 , obo:RO_0002320 .

obo:RO_HOM0000004 a rdf:Property ;
  rdfs:label "in convergence relationship with" ;
  rdfs:comment "Homoplasy that involves different underlying mechanisms or structures." ;
  rdfs:seeAlso obo:HOM_0000004 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000002 .

obo:RO_HOM0000005 a rdf:Property ;
  rdfs:label "in parallelism relationship with" ;
  rdfs:comment "Homoplasy that involves homologous underlying mechanisms or structures." ;
  rdfs:seeAlso obo:HOM_0000005 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000002 .

obo:RO_HOM0000006 a rdf:Property ;
  rdfs:label "in structural homology relationship with" ;
  rdfs:comment "Homology that is defined by similarity with regard to selected structural parameters." ;
  rdfs:seeAlso obo:HOM_0000006 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000001 .

obo:RO_HOM0000007 a rdf:Property ;
  rdfs:label "in historical homology relationship with" ;
  rdfs:comment "Homology that is defined by common descent." ;
  rdfs:seeAlso obo:HOM_0000007 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000001 .

obo:RO_HOM0000008 a rdf:Property ;
  rdfs:label "in biological homology relationship with" ;
  rdfs:comment "Homology that is defined by sharing of a set of developmental constraints, caused by locally acting self-regulatory mechanisms of differentiation, between individualized parts of the phenotype." ;
  rdfs:seeAlso obo:HOM_0000008 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000001 .

obo:RO_HOM0000009 a rdf:Property ;
  rdfs:label "in reversal relationship with" ;
  rdfs:comment "Homoplasy that involves phenotypes similar to those seen in ancestors within the lineage." ;
  rdfs:seeAlso obo:HOM_0000009 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000002 .

obo:RO_HOM0000010 a rdf:Property ;
  rdfs:label "in syntenic homology relationship with" ;
  rdfs:comment "Structural homology that is detected by similarity in content and organization between chromosomes." ;
  rdfs:seeAlso obo:HOM_0000010 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000006 .

obo:RO_HOM0000011 a rdf:Property ;
  rdfs:label "in paralogy relationship with" ;
  rdfs:comment "Historical homology that involves genes that diverged after a duplication event." ;
  rdfs:seeAlso obo:HOM_0000011 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000012 a rdf:Property ;
  rdfs:label "in syntenic paralogy relationship with" ;
  rdfs:comment "Paralogy that involves sets of syntenic blocks." ;
  rdfs:seeAlso obo:HOM_0000012 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 , obo:RO_HOM0000010 .

obo:RO_HOM0000013 a rdf:Property ;
  rdfs:label "in syntenic orthology relationship with" ;
  rdfs:comment "Syntenic homology that involves chromosomes of different species." ;
  rdfs:seeAlso obo:HOM_0000013 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000010 .

obo:RO_HOM0000014 a rdf:Property ;
  rdfs:label "in partial homology relationship with" ;
  rdfs:comment "Structural homology that involves complex structures from which only a fraction of the elements that can be isolated are separately homologous." ;
  rdfs:seeAlso obo:HOM_0000014 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000006 .

obo:RO_HOM0000015 a rdf:Property ;
  rdfs:label "in protein structural homology relationship with" ;
  rdfs:comment "Structural homology that is detected at the level of the 3D protein structure, but maybe not at the level of the amino acid sequence." ;
  rdfs:seeAlso obo:HOM_0000015 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000006 .

obo:RO_HOM0000016 a rdf:Property ;
  rdfs:label "in non functional homology relationship with" ;
  rdfs:comment "Structural homology that involves a pseudogenic feature and its functional ancestor." ;
  rdfs:seeAlso obo:HOM_0000016 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000006 .

obo:RO_HOM0000017 a rdf:Property ;
  rdfs:label "in orthology relationship with" ;
  rdfs:comment "Historical homology that involves genes that diverged after a speciation event." ;
  rdfs:seeAlso obo:HOM_0000017 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000018 a rdf:Property ;
  rdfs:label "in xenology relationship with" ;
  rdfs:comment "Historical homology that is characterized by an interspecies (horizontal) transfer since the common ancestor." ;
  rdfs:seeAlso obo:HOM_0000018 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000019 a rdf:Property ;
  rdfs:label "in 1 to 1 homology relationship with" ;
  rdfs:comment "Historical homology that involves two members sharing no other homologs in the lineages considered." ;
  rdfs:seeAlso obo:HOM_0000019 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000020 a rdf:Property ;
  rdfs:label "in 1 to 1 orthology relationship with" ;
  rdfs:comment "Orthology that involves two genes that did not experience any duplication after the speciation event that created them." ;
  rdfs:seeAlso obo:HOM_0000020 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000019 , obo:RO_HOM0000017 .

obo:RO_HOM0000022 a rdf:Property ;
  rdfs:label "in ohnology relationship with" ;
  rdfs:comment "Paralogy that results from a whole genome duplication event." ;
  rdfs:seeAlso obo:HOM_0000022 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 .

obo:RO_HOM0000023 a rdf:Property ;
  rdfs:label "in in-paralogy relationship with" ;
  rdfs:comment "Paralogy that results from a lineage-specific duplication subsequent to a given speciation event." ;
  rdfs:seeAlso obo:HOM_0000023 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 .

obo:RO_HOM0000024 a rdf:Property ;
  rdfs:label "in out-paralogy relationship with" ;
  rdfs:comment "Paralogy that results from a duplication preceding a given speciation event." ;
  rdfs:seeAlso obo:HOM_0000024 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 .

obo:RO_HOM0000025 a rdf:Property ;
  rdfs:label "in pro-orthology relationship with" ;
  rdfs:comment "1:many orthology that involves a gene in species A and one of its ortholog in species B, when duplications more recent than the species split have occurred in species B but not in species A." ;
  rdfs:seeAlso obo:HOM_0000025 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000034 .

obo:RO_HOM0000026 a rdf:Property ;
  rdfs:label "in semi-orthology relationship with" ;
  rdfs:comment "1:many orthology that involves a gene in species A and its ortholog in species B, when duplications more recent than the species split have occurred in species A but not in species B." ;
  rdfs:seeAlso obo:HOM_0000026 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000034 .

obo:RO_HOM0000027 a rdf:Property ;
  rdfs:label "in serial homology relationship with" ;
  rdfs:comment "Iterative homology that involves structures arranged along the main body axis." ;
  rdfs:seeAlso obo:HOM_0000027 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000066 .

obo:RO_HOM0000028 a rdf:Property ;
  rdfs:label "in heterochronous homology relationship with" ;
  rdfs:comment "Biological homology that is characterized by changes, over evolutionary time, in the rate or timing of developmental events of homologous structures." ;
  rdfs:seeAlso obo:HOM_0000028 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000008 .

obo:RO_HOM0000029 a rdf:Property ;
  rdfs:label "in paedomorphorsis relationship with" ;
  rdfs:comment "Heterochronous homology that is produced by a retention in adults of a species of traits previously seen only in juveniles." ;
  rdfs:seeAlso obo:HOM_0000029 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000028 .

obo:RO_HOM0000030 a rdf:Property ;
  rdfs:label "in peramorphosis relationship with" ;
  rdfs:comment "Heterochronous homology that is produced by a maturation of individuals of a species past adulthood, which take on hitherto unseen traits." ;
  rdfs:seeAlso obo:HOM_0000030 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000028 .

obo:RO_HOM0000031 a rdf:Property ;
  rdfs:label "in progenesis relationship with" ;
  rdfs:comment "Paedomorphosis that is produced by precocious sexual maturation of an organism still in a morphologically juvenile stage." ;
  rdfs:seeAlso obo:HOM_0000031 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000029 .

obo:RO_HOM0000032 a rdf:Property ;
  rdfs:label "in neoteny relationship with" ;
  rdfs:comment "Paedomorphosis that is produced by a retardation of somatic development." ;
  rdfs:seeAlso obo:HOM_0000032 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000029 .

obo:RO_HOM0000033 a rdf:Property ;
  rdfs:label "in mimicry relationship with" ;
  rdfs:comment "Convergence that results from co-evolution usually involving an evolutionary arms race." ;
  rdfs:seeAlso obo:HOM_0000033 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000004 .

obo:RO_HOM0000034 a rdf:Property ;
  rdfs:label "in 1 to many orthology relationship with" ;
  rdfs:comment "Orthology that involves two genes when duplications more recent than the species split have occurred in one species but not the other." ;
  rdfs:seeAlso obo:HOM_0000034 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000037 , obo:RO_HOM0000017 .

obo:RO_HOM0000036 a rdf:Property ;
  rdfs:label "in many to many homology relationship with" ;
  rdfs:comment "Historical homology that involves two members of a larger set of homologs." ;
  rdfs:seeAlso obo:HOM_0000036 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000037 a rdf:Property ;
  rdfs:label "in 1 to many homology relationship with" ;
  rdfs:comment "Historical homology that involves a structure that has no other homologs in the species in which it is defined, and several homologous structures in another species." ;
  rdfs:seeAlso obo:HOM_0000037 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000042 a rdf:Property ;
  rdfs:label "in apomorphy relationship with" ;
  rdfs:comment "Historical homology that is based on recent shared ancestry, characterizing a monophyletic group." ;
  rdfs:seeAlso obo:HOM_0000042 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000043 a rdf:Property ;
  rdfs:label "in plesiomorphy relationship with" ;
  rdfs:comment "Historical homology that is based on distant shared ancestry." ;
  rdfs:seeAlso obo:HOM_0000043 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000044 a rdf:Property ;
  rdfs:label "in deep homology relationship with" ;
  rdfs:comment "Homocracy that involves morphologically and phylogenetically disparate structures that are the result of parallel evolution." ;
  rdfs:seeAlso obo:HOM_0000044 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000005 , obo:RO_HOM0000003 .

obo:RO_HOM0000045 a rdf:Property ;
  rdfs:label "in hemiplasy relationship with" ;
  rdfs:comment "Historical homology that is characterized by topological discordance between a gene tree and a species tree attributable to the phylogenetic sorting of genetic polymorphisms across successive nodes in a species tree." ;
  rdfs:seeAlso obo:HOM_0000045 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000046 a rdf:Property ;
  rdfs:label "in gametology relationship with" ;
  rdfs:comment "Historical homology that involves not recombining and subsequently differentiated sex chromosomes." ;
  rdfs:seeAlso obo:HOM_0000046 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000047 .

obo:RO_HOM0000047 a rdf:Property ;
  rdfs:label "in chromosomal homology relationship with" ;
  rdfs:comment "Historical homology that involves the chromosomes able to pair (synapse) during meiosis." ;
  rdfs:seeAlso obo:HOM_0000047 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000048 a rdf:Property ;
  rdfs:label "in many to many orthology relationship with" ;
  rdfs:comment "Orthology that involves two genes that experienced duplications more recent than the species split that created them." ;
  rdfs:seeAlso obo:HOM_0000048 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000036 , obo:RO_HOM0000017 .

obo:RO_HOM0000049 a rdf:Property ;
  rdfs:label "in within-species paralogy relationship with" ;
  rdfs:comment "Paralogy that involves genes from the same species." ;
  rdfs:seeAlso obo:HOM_0000049 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 .

obo:RO_HOM0000050 a rdf:Property ;
  rdfs:label "in between-species paralogy relationship with" ;
  rdfs:comment "Paralogy that involves genes from different species." ;
  rdfs:seeAlso obo:HOM_0000050 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 .

obo:RO_HOM0000051 a rdf:Property ;
  rdfs:label "in postdisplacement relationship with" ;
  rdfs:comment "Paedomorphosis that is produced by delayed growth of immature structures into the adult form." ;
  rdfs:seeAlso obo:HOM_0000051 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000029 .

obo:RO_HOM0000052 a rdf:Property ;
  rdfs:label "in hypermorphosis relationship with" ;
  rdfs:comment "Peramorphosis that is produced by a delay in the offset of development." ;
  rdfs:seeAlso obo:HOM_0000052 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000030 .

obo:RO_HOM0000053 a rdf:Property ;
  rdfs:label "in synology relationship with" ;
  rdfs:comment "Xenology that results, not from the transfer of a gene between two species, but from a hybridization of two species." ;
  rdfs:seeAlso obo:HOM_0000053 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000018 .

obo:RO_HOM0000054 a rdf:Property ;
  rdfs:label "in isoorthology relationship with" ;
  rdfs:comment "Orthology that involves functional equivalent genes with retention of the ancestral function." ;
  rdfs:seeAlso obo:HOM_0000054 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000062 , obo:RO_HOM0000017 .

obo:RO_HOM0000055 a rdf:Property ;
  rdfs:label "in tandem paralogy relationship with" ;
  rdfs:comment "Paralogy that is characterized by duplication of adjacent sequences on a chromosome segment." ;
  rdfs:seeAlso obo:HOM_0000055 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 .

obo:RO_HOM0000057 a rdf:Property ;
  rdfs:label "in latent homology relationship with" ;
  rdfs:comment "Parallelism that involves morphologically very similar structures, occurring only within some members of a taxon and absent in the common ancestor (which possessed the developmental basis to develop this character)." ;
  rdfs:seeAlso obo:HOM_0000057 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000058 , obo:RO_HOM0000005 .

obo:RO_HOM0000058 a rdf:Property ;
  rdfs:label "in syngeny relationship with" ;
  rdfs:comment "Homocracy that involves recognizably corresponding characters that occurs in two or more taxa, or as a repeated unit within an individual." ;
  rdfs:seeAlso obo:HOM_0000058 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000003 .

obo:RO_HOM0000060 a rdf:Property ;
  rdfs:label "in apparent orthology relationship with" ;
  rdfs:comment "Between-species paralogy that involves single copy paralogs resulting from reciprocal gene loss." ;
  rdfs:seeAlso obo:HOM_0000060 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000050 , obo:RO_HOM0000019 .

obo:RO_HOM0000061 a rdf:Property ;
  rdfs:label "in pseudoparalogy relationship with" ;
  rdfs:comment "Xenology that involves genes that ended up in a given genome as a result of a combination of vertical inheritance and horizontal gene transfer." ;
  rdfs:seeAlso obo:HOM_0000061 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000018 .

obo:RO_HOM0000062 a rdf:Property ;
  rdfs:label "in equivalogy relationship with" ;
  rdfs:comment "Historical homology that involves functional equivalent genes with retention of the ancestral function." ;
  rdfs:seeAlso obo:HOM_0000062 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000065 , obo:RO_HOM0000007 .

obo:RO_HOM0000063 a rdf:Property ;
  rdfs:label "in interology relationship with" ;
  rdfs:comment "Historical homology that involves orthologous pairs of interacting molecules in different organisms." ;
  rdfs:seeAlso obo:HOM_0000063 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

obo:RO_HOM0000065 a rdf:Property ;
  rdfs:label "in functional equivalence relationship with" ;
  rdfs:comment "Similarity that is characterized by interchangeability in function." ;
  rdfs:seeAlso obo:HOM_0000065 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000000 .

obo:RO_HOM0000066 a rdf:Property ;
  rdfs:label "in iterative homology relationship with" ;
  rdfs:comment "Biological homology that involves parts of the same organism." ;
  rdfs:seeAlso obo:HOM_0000066 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000008 .

obo:RO_HOM0000068 a rdf:Property ;
  rdfs:label "in paraxenology relationship with" ;
  rdfs:comment "Xenology that is characterized by multiple horizontal transfer events, resulting in the presence of two or more copies of the foreign gene in the host genome." ;
  rdfs:seeAlso obo:HOM_0000068 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000018 .

obo:RO_HOM0000069 a rdf:Property ;
  rdfs:label "in plerology relationship with" ;
  rdfs:comment "Paralogy that is characterized by extra similarity between paralogous sequences resulting from concerted evolution." ;
  rdfs:seeAlso obo:HOM_0000069 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000011 .

obo:RO_HOM0000071 a rdf:Property ;
  rdfs:label "in homotopy relationship with" ;
  rdfs:comment "Structural homology that involves structures with the same or similar relative positions." ;
  rdfs:seeAlso obo:HOM_0000071 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000006 .

obo:RO_HOM0000072 a rdf:Property ;
  rdfs:label "in homeosis relationship with" ;
  rdfs:comment "Biological homology that involves an ectopic structure and the normally positioned structure." ;
  rdfs:seeAlso obo:HOM_0000072 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000008 .

obo:RO_HOM0000073 a rdf:Property ;
  rdfs:label "in homoeology relationship with" ;
  rdfs:comment "Synology that results from allopolyploidy." ;
  rdfs:seeAlso obo:HOM_0000073 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000053 , obo:RO_HOM0000022 .

obo:RO_HOM0000074 a rdf:Property ;
  rdfs:label "in paramorphism relationship with" ;
  rdfs:comment "Iterative homology that involves two structures, one of which originated as a duplicate of the other and co-opted the expression of patterning genes of the ancestral structure." ;
  rdfs:seeAlso obo:HOM_0000074 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000066 , obo:RO_HOM0000003 .

obo:RO_HOM0000075 a rdf:Property ;
  rdfs:label "in regulogy relationship with" ;
  rdfs:comment "Historical homology that involves orthologous pairs of transcription factors and downstream regulated genes in different organisms." ;
  rdfs:seeAlso obo:HOM_0000075 ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_HOM0000007 .

<http://purl.obolibrary.org/obo/envo#has_increased_levels_of> a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/ro/subsets#ro-eco> a rdf:Property ;
  rdfs:label "eco subset" ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/subsets/> ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#common_anatomy> a rdf:Property ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#upper_level> a rdf:Property ;
  rdfs:range xsd:string .

obo:valid_for_go_annotation_extension a rdf:Property ;
  rdfs:label "valid_for_go_annotation_extension"@en ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/subsets/> ;
  rdfs:range xsd:string .

obo:valid_for_go_gp2term a rdf:Property ;
  rdfs:label "valid_for_go_gp2term"@en ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/subsets/> ;
  rdfs:range xsd:string .

obo:valid_for_go_ontology a rdf:Property ;
  rdfs:label "valid_for_go_ontology"@en ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/subsets/> ;
  rdfs:range xsd:string .

obo:valid_for_gocam a rdf:Property ;
  rdfs:label "valid_for_gocam"@en ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/ro/docs/subsets/> ;
  rdfs:range xsd:string .

obo:IAO_0000078 a rdfs:Class ;
  rdfs:label "curation status specification"@en ;
  rdfs:comment "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en .

obo:IAO_0000002 a obo:IAO_0000078 ;
  rdfs:label "example to be eventually removed"@en .

obo:IAO_0000120 a obo:IAO_0000078 ;
  rdfs:label "metadata complete"@en ;
  rdfs:comment "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en .

obo:IAO_0000121 a obo:IAO_0000078 ;
  rdfs:label "organizational term"@en ;
  rdfs:comment "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en .

obo:IAO_0000122 a obo:IAO_0000078 ;
  rdfs:label "ready for release"@en ;
  rdfs:comment "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release.  Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""@en .

obo:IAO_0000123 a obo:IAO_0000078 ;
  rdfs:label "metadata incomplete"@en ;
  rdfs:comment "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en .

obo:IAO_0000124 a obo:IAO_0000078 ;
  rdfs:label "uncurated"@en ;
  rdfs:comment "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en .

obo:IAO_0000125 a obo:IAO_0000078 ;
  rdfs:label "pending final vetting"@en ;
  rdfs:comment "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en .

obo:IAO_0000423 a obo:IAO_0000078 ;
  rdfs:label "to be replaced with external ontology term"@en ;
  rdfs:comment "Terms with this status should eventually replaced with a term from another ontology."@en .

obo:IAO_0000428 a obo:IAO_0000078 ;
  rdfs:label "requires discussion"@en ;
  rdfs:comment "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en .
