PREFIX obo:
PREFIX rdf:
PREFIX rdfs:
PREFIX xsd:
a rdfs:Class ;
rdfs:label "quantitative systems description parameter" ;
rdfs:comment "A numerical value that defines certain characteristics of systems or system functions. It may be part of a calculation, but its value is not determined by the form of the equation itself, and may be arbitrarily assigned." ;
rdfs:subClassOf obo:IAO_0000030 .
obo:OBI_0001938 a rdf:Property ;
rdfs:label "has value specification" ;
rdfs:comment "A relation between an information content entity and a value specification that specifies its value." ;
rdfs:domain obo:IAO_0000030 ;
rdfs:range ;
rdfs:subPropertyOf obo:BFO_0000051 .
obo:RO_0000056 a rdf:Property ;
rdfs:label "participates in"@en ;
rdfs:comment "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
rdfs:domain obo:BFO_0000002 ;
rdfs:range obo:BFO_0000003 .
obo:IAO_0000219 a rdf:Property ;
rdfs:label "denotes"@en ;
rdfs:comment "A primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically"@en ;
rdfs:domain obo:IAO_0000030 ;
rdfs:range obo:BFO_0000001 ;
rdfs:subPropertyOf obo:IAO_0000136 .
obo:IAO_0000136 a rdf:Property ;
rdfs:label "is about"@en ;
rdfs:comment "A (currently) primitive relation that relates an information artifact to an entity."@en ;
rdfs:domain obo:IAO_0000030 ;
rdfs:range .
a rdf:Property ;
rdfs:label "has facet" ;
rdfs:comment "Relation between an information content entity and some part of it called a facet that is covers some general aspect of information context. [Allotrope]" ;
rdfs:domain obo:IAO_0000030 ;
rdfs:range ;
rdfs:subPropertyOf .
obo:IAO_0000235 a rdf:Property ;
rdfs:label "denoted by"@en ;
rdfs:comment "inverse of the relation 'denotes'"@en ;
rdfs:domain obo:BFO_0000001 ;
rdfs:range obo:IAO_0000030 .
obo:CHMO_0002465 a rdfs:Class ;
rdfs:label "solvent precipitation" ;
rdfs:comment "The sedimentation of a solid material (a 'precipitate') from a liquid solution caused by the addition of an additional different solvent." ;
rdfs:subClassOf obo:CHMO_0001688 .
obo:OBI_0000299 a rdf:Property ;
rdfs:label "has_specified_output"@en ;
rdfs:comment "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
rdfs:domain obo:OBI_0000011 ;
rdfs:range obo:BFO_0000002 ;
rdfs:subPropertyOf obo:RO_0000057 .
obo:OBI_0000417 a rdf:Property ;
rdfs:label "achieves_planned_objective" ;
rdfs:comment "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process." ;
rdfs:domain obo:OBI_0000011 ;
rdfs:range obo:IAO_0000005 .
obo:OBI_0000293 a rdf:Property ;
rdfs:label "has_specified_input"@en ;
rdfs:comment "A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
rdfs:domain obo:OBI_0000011 ;
rdfs:range obo:BFO_0000040 , obo:BFO_0000002 , obo:IAO_0000027 ;
rdfs:subPropertyOf obo:RO_0000057 .
obo:BFO_0000055 a rdf:Property ;
rdfs:label "realizes"@en ;
rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
rdfs:domain obo:BFO_0000015 ;
rdfs:range obo:BFO_0000017 .
obo:RO_0000057 a rdf:Property ;
rdfs:label "has participant"@en ;
rdfs:comment "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
rdfs:domain obo:BFO_0000003 ;
rdfs:range obo:BFO_0000002 .
obo:PROCO_0000243 a rdfs:Class ;
rdfs:label "rhombic-dipyramidal" ;
rdfs:comment "8-faced form orthorhombic crystal class with centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:RO_0000059 a rdf:Property ;
rdfs:label "concretizes"@en ;
rdfs:comment "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ;
rdfs:domain obo:BFO_0000020 ;
rdfs:range obo:BFO_0000031 .
a rdf:Property ;
rdfs:label "quality influenced by" ;
rdfs:comment "Inverse of quality influences. [Allotrope]" ;
rdfs:range ;
rdfs:subPropertyOf obo:RO_0002502 .
obo:RO_0000052 a rdf:Property ;
rdfs:label "inheres in"@en ;
rdfs:comment "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence"@en ;
rdfs:range .
obo:CHEBI_35225 a rdfs:Class ;
rdfs:label "buffer" ;
rdfs:comment "Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:BFO_0000054 a rdf:Property ;
rdfs:label "realized in"@en ;
rdfs:comment "Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
rdfs:domain obo:BFO_0000017 ;
rdfs:range obo:BFO_0000015 , obo:OBI_0000070 , obo:OBI_0000415 .
obo:BFO_0000017 a rdfs:Class ;
rdfs:label "realizable entity"@en ;
rdfs:comment "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ;
rdfs:subClassOf obo:BFO_0000020 .
obo:CHMO_0002634 a rdfs:Class ;
rdfs:label "azeotropic distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. An azeotrope (a mixture of two or more liquids which produces vapor with the same ratio of constituents as the original mixture) cannot be separated by normal distillation, therefore an additional third component (known as an 'entrainer') is added to the mixture. This has the effect of changing the volatility of one of liquids in the azeotrope to a greater extent than the other, allowing separation to occur." ;
rdfs:subClassOf obo:CHMO_0001532 .
a rdfs:Class ;
rdfs:label "container" ;
rdfs:comment "A device that has the function to contain material. [Allotrope]" ;
rdfs:subClassOf .
a rdf:Property ;
rdfs:label "contained in" ;
rdfs:comment "Inverse of contains. [Allotrope]" ;
rdfs:domain obo:BFO_0000040 ;
rdfs:range ;
rdfs:subPropertyOf obo:RO_0001025 .
a rdf:Property ;
rdfs:label "contains" ;
rdfs:comment "The relation between a container and its physical content. A material entity a contains a material entity b if b is located in some cavity of a. [Allotrope]" ;
rdfs:domain ;
rdfs:range obo:BFO_0000040 ;
rdfs:subPropertyOf obo:RO_0001015 .
obo:RO_0000087 a rdf:Property ;
rdfs:label "has role" ;
rdfs:comment "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
rdfs:domain obo:BFO_0000004 ;
rdfs:range obo:BFO_0000023 ;
rdfs:subPropertyOf obo:RO_0000053 .
obo:RO_0000085 a rdf:Property ;
rdfs:label "has function"@en ;
rdfs:comment "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
rdfs:domain obo:BFO_0000004 ;
rdfs:range obo:BFO_0000034 ;
rdfs:subPropertyOf obo:RO_0000053 .
obo:PROCO_0000114 a rdfs:Class ;
rdfs:label "non-centrosymmetric point symmetry"@en ;
rdfs:comment "a point symmetry of a structure that is not identical to any inversion of that structure created by reflecting all of its points through a single point."@en ;
rdfs:subClassOf obo:PROCO_0000111 .
obo:PROCO_0000125 a rdfs:Class ;
rdfs:label "hexagonal unit cell"@en ;
rdfs:comment "A unit cell of three equal lateral axes intersecting at angles of 60 degrees and a vertical axis of variable length at right angles" ;
rdfs:subClassOf obo:PROCO_0000120 .
obo:IAO_0000009 a rdfs:Class ;
rdfs:label "datum label"@en ;
rdfs:comment "A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label"@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PROCO_0000181 a rdfs:Class ;
rdfs:label "Graham condensor"@en ;
rdfs:comment "A condensor with a coolant-jacketed spiral coil running the length of the condenser serving as the vapor–condensate path, providing more surface area for cooling." ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:CHEBI_72695 a rdfs:Class ;
rdfs:label "organic molecule" ;
rdfs:comment "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." ;
rdfs:subClassOf obo:CHEBI_25367 , obo:CHEBI_50860 .
obo:BFO_0000051 a rdf:Property ;
rdfs:label "has part" ;
rdfs:comment "a core relation that holds between a whole and its part"@en ;
rdfs:range .
obo:CHEBI_18407 a rdfs:Class ;
rdfs:label "hydrogen cyanide" ;
rdfs:comment "A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom" ;
rdfs:subClassOf obo:CHEBI_33405 , obo:CHEBI_64708 .
a rdf:Property ;
rdfs:label "is conjugate acid of" ;
rdfs:range .
a rdf:Property ;
rdfs:label "is tautomer of" ;
rdfs:range .
obo:OBI_0000094 a rdfs:Class ;
rdfs:label "material processing" ;
rdfs:comment "A planned process which results in physical changes in a specified input material." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHMO_0002772 a rdfs:Class ;
rdfs:label "degassing" ;
rdfs:comment "A preparative step involving the removal of dissolved gases from a sample." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:CHEBI_63046 a rdfs:Class ;
rdfs:label "emulsifier" ;
rdfs:comment "The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:BFO_0000034 a rdfs:Class ;
rdfs:label "function"@en ;
rdfs:subClassOf obo:BFO_0000016 .
obo:CHEBI_33318 a rdfs:Class ;
rdfs:label "main group element atom" ;
rdfs:comment "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." ;
rdfs:subClassOf obo:CHEBI_33250 .
obo:CHEBI_33405 a rdfs:Class ;
rdfs:label "hydracid" ;
rdfs:comment "A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." ;
rdfs:subClassOf obo:CHEBI_33608 .
obo:PROCO_0000248 a rdfs:Class ;
rdfs:label "tetragonal-dipyramidal" ;
rdfs:comment "8-faced form with centrosymmetric point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_25693 a rdfs:Class ;
rdfs:label "organic heteromonocyclic compound" ;
rdfs:subClassOf obo:CHEBI_24532 , obo:CHEBI_33670 .
a rdfs:Class ;
rdfs:label "specified degradation product role" ;
rdfs:comment "A degradation product role that is individually listed and limited with a specific acceptance criterion in the new drug product specification. A specified degradation product can be either identified or unidentified. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:PROCO_0000010 a rdfs:Class ;
rdfs:label "route selection milestone"@en ;
rdfs:comment "A process boundary that represents a milestone decision on route selection." ;
rdfs:subClassOf obo:BFO_0000035 .
obo:PROCO_0000200 a rdfs:Class ;
rdfs:label "flocculant"@en ;
rdfs:comment "A synthesis role used to remove suspended solids from liquids by inducing flocculation (the solids begin to aggregate forming flakes, which either precipitate to the bottom or float to the surface of the liquid, and then they can be removed or collected). Flocculants, or flocculating agents (also known as flocking agents), are chemicals that promote flocculation by causing colloids and other suspended particles in liquids to aggregate, forming a floc." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:PROCO_0000091 a rdfs:Class ;
rdfs:label "screening design"@en ;
rdfs:comment "A process chemistry workflow plan that specifies how a multi-parallel screening study should be conducted." ;
rdfs:subClassOf obo:PROCO_0000093 .
a rdf:Property ;
rdfs:range .
obo:CHMO_0002653 a rdfs:Class ;
rdfs:label "surface-assisted chemical vapour transport" ;
rdfs:comment "A crystal growth method for metal dichalcogenides in which the starting materials (high-purity metal and chalcogen powders) are placed in one half of a quartz ampoule together with a transport agent (e.g. iodine) and heated in a furnace under a temperature gradient. The product crystals are grown on the surface of a sheet of high-purity metal in the other half of the ampoule." ;
rdfs:subClassOf obo:CHMO_0002652 .
obo:CHEBI_63060 a rdfs:Class ;
rdfs:label "phase-transfer catalyst" ;
rdfs:comment "A catalyst that facilitates the migration of a reactant from one phase into another phase where reaction occurs." ;
rdfs:subClassOf obo:CHEBI_35223 .
obo:PROCO_0000226 a rdfs:Class ;
rdfs:label "Reaction Progress Kinetic Analysis" ;
rdfs:comment "Mechanistic and kinetic determinations utilized to determine the rate laws of chemical reactions and to aid in elucidation of reaction mechanisms. While the concepts guiding reaction progress kinetic analysis are not new, the process was formalized by Professor Donna Blackmond (currently at Scripps Research Institute) in the late 1990s and has since seen increasingly widespread use. Unlike more common pseudo-first-order analysis, in which an overwhelming excess of one or more reagents is used relative to a species of interest, RPKA probes reactions at synthetically relevant conditions (i.e. with concentrations and reagent ratios resembling those used in the reaction when not exploring the rate law.) Generally, this analysis involves a system in which the concentrations of multiple reactants are changing measurably over the course of the reaction. As the mechanism can vary depending on the relative and absolute concentrations of the species involved, this approach obtains results that are much more representative of reaction behavior under commonly utilized conditions than do traditional tactics. Furthermore, information obtained by observation of the reaction over time may provide insight regarding unexpected behavior such as induction periods, catalyst deactivation, or changes in mechanism." ;
rdfs:subClassOf obo:PROCO_0000085 .
obo:CHMO_0001597 a rdfs:Class ;
rdfs:label "sequentional extraction" ;
rdfs:comment "An analytical process that sequentially chemically leaches metals from soils, sludges or sediments." ;
rdfs:subClassOf obo:CHMO_0001577 .
obo:CHEBI_26672 a rdfs:Class ;
rdfs:label "siderophore" ;
rdfs:comment "Any of low-molecular-mass iron(III)-chelating compounds produced by microorganisms for the purpose of the transport and sequestration of iron." ;
rdfs:subClassOf obo:CHEBI_23357 , obo:CHEBI_24028 , obo:CHEBI_24874 .
obo:PROCO_0000232 a rdfs:Class ;
rdfs:label "reaction rate" ;
rdfs:comment "A measurement datum about the speed at which a chemical reaction takes place, defined as proportional to the increase in the concentration of a product per unit time and to the decrease in the concentration of a reactant per unit time." ;
rdfs:subClassOf obo:IAO_0000109 .
obo:CHEBI_33662 a rdfs:Class ;
rdfs:label "annulene" ;
rdfs:comment "A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms." ;
rdfs:subClassOf obo:CHEBI_33664 .
a rdfs:Class ;
rdfs:label "detergent role" ;
rdfs:comment "A detergent role is a cleaning role of a surface active agent (or a mixture containing one of more surface active agents) having cleaning properties in dilute solution. [IUPAC]" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "state" ;
rdfs:comment "A state is a homomeric, cumulative process in which all the temporal parts are described by the same expression used for the whole. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000015 .
obo:CHMO_0001612 a rdfs:Class ;
rdfs:label "substoichiometric extraction" ;
rdfs:comment "The process of transferring a substance from any matrix to another where the amount of reagent used is lower than that dictated by stoichiometry." ;
rdfs:subClassOf obo:CHMO_0001577 .
obo:CHEBI_36388 a rdfs:Class ;
rdfs:label "saturated organic heterocyclic parent" ;
rdfs:subClassOf obo:CHEBI_35552 .
obo:CHMO_0001594 a rdfs:Class ;
rdfs:label "membrane extraction with a sorbent interface" ;
rdfs:comment "The transfer of a solute from one phase (the 'donor' or 'feed' phase) to another (the 'acceptor' or 'strip' phase) across a non-porous non-polar polymer membrane. The membrane first extracts the analytes from their matrix, and these are subsequently trapped on a polymeric trap with a porous sorbent using a carrier gas stream." ;
rdfs:subClassOf obo:CHMO_0001593 .
obo:PROCO_0000078 a rdfs:Class ;
rdfs:label "quality service level"@en ;
rdfs:comment "The quality service level (QSL) is a measure of the reproducibility of the quality of the isolated intermediate or final API, and its calculation involves the ratio of satisfactory quality batches to the total number of batches. A reasonable QSL target is 98 to 100 percent." ;
rdfs:subClassOf obo:PROCO_0000295 .
obo:CHEBI_36340 a rdfs:Class ;
rdfs:label "fermion" ;
rdfs:comment "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." ;
rdfs:subClassOf obo:CHEBI_36342 .
obo:PROCO_0000215 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.2.2 Description of Manufacturing Process and Process Controls"@en ;
rdfs:comment "The description of the drug substance manufacturing process represents the applicant’s commitment for the manufacture of the drug substance. Reference ICH guidances Q5A, Q5B, and Q6B." ;
rdfs:subClassOf obo:IAO_0000314 .
obo:BFO_0000050 a rdf:Property ;
rdfs:label "part of"@en ;
rdfs:comment "a core relation that holds between a part and its whole"@en ;
rdfs:seeAlso ;
rdfs:range .
obo:PROCO_0000170 a rdfs:Class ;
rdfs:label "X-Ray diffractivity"@en ;
rdfs:comment "A chemical substance quality of a crystalline phase that manifests itself as a set of allowed and unallowed peaks corresponding to the diffraction of incident x-ray radiation as a function of the substance's unit cell and its space group." ;
rdfs:subClassOf .
obo:CHEBI_46926 a rdfs:Class ;
rdfs:label "dioxanes" ;
rdfs:subClassOf obo:CHEBI_25693 , obo:CHEBI_38104 .
obo:CHMO_0001685 a rdfs:Class ;
rdfs:label "mixing" ;
rdfs:comment "The combining of components, particles or layers into a more homogeneous state. The mixing may be achieved manually or mechanically by shifting the material with stirrers or pumps or by revolving or shaking the container. The process μst not permit segregation of particles of different size or properties. Homogeneity may be considered to have been achieved in a practical sense when the sampling error of the processed portion is negligible compared to the total error of the measurement system." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:CHEBI_51867 a rdfs:Class ;
rdfs:label "methyl ketone" ;
rdfs:comment "A ketone of formula RC(=O)CH3 (R =/= H)." ;
rdfs:subClassOf obo:CHEBI_17087 .
obo:CHEBI_48819 a rdfs:Class ;
rdfs:label "cyano group" ;
rdfs:subClassOf obo:CHEBI_36823 .
a rdf:Property ;
rdfs:label "is substituent group from" ;
rdfs:range .
obo:PROCO_0000004 a rdfs:Class ;
rdfs:label "design space"@en ;
rdfs:comment "A direct information entity that describes the multidimensional combination and interaction of input variables (e.g., material attributes) and process parameters that have been demonstrated to provide assurance of quality. Working within the design space is not considered as a change. Movement out of the design space is considered to be a change and would normally initiate a regulatory post-approval change process. Design space is proposed by the applicant and is subject to regulatory assessment and approval." ;
rdfs:subClassOf obo:IAO_0000033 .
obo:CHMO_0001557 a rdfs:Class ;
rdfs:label "vacuum drying" ;
rdfs:comment "The removal of water from a sample by placing it under reduced pressure. This allows water to evaporate from (heat-sensitive) samples at a lower temperature." ;
rdfs:subClassOf obo:CHMO_0001549 .
obo:CHMO_0002157 a rdfs:Class ;
rdfs:label "deionisation method" ;
rdfs:comment "The removal of ions from a solution using an ion-exchange method." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:OBI_0001933 a rdfs:Class ;
rdfs:label "value specification" ;
rdfs:comment "An information content entity that specifies a value within a classification scheme or on a quantitative scale." ;
rdfs:subClassOf obo:IAO_0000030 .
obo:OBI_0002135 a rdf:Property ;
rdfs:label "has specified value"@en ;
rdfs:comment "A relation between a value specification and a literal." ;
rdfs:domain obo:OBI_0001933 ;
rdfs:range .
obo:OBI_0001937 a rdf:Property ;
rdfs:label "has specified numeric value" ;
rdfs:comment "A relation between a value specification and a number that quantifies it." ;
rdfs:domain obo:OBI_0001933 ;
rdfs:range ;
rdfs:subPropertyOf obo:OBI_0002135 .
obo:CHEBI_50047 a rdfs:Class ;
rdfs:label "organic amino compound" ;
rdfs:comment "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." ;
rdfs:subClassOf obo:CHEBI_35352 , obo:CHEBI_50860 .
a rdf:Property ;
rdfs:label "has parent hydride" ;
rdfs:range .
a rdfs:Class .
obo:CHMO_0002917 a rdfs:Class ;
rdfs:label "sample quenching" ;
rdfs:comment "Material processing in which a sample is cooled by immersion in a fluid." ;
rdfs:subClassOf obo:OBI_0000094 .
obo:CHMO_0001601 a rdfs:Class ;
rdfs:label "cloud-point extraction" ;
rdfs:comment "The process of transferring a non-ionic surfactant from one liquid phase to another by heating. As the temperature of the solution rises, the surfactant molecules form micelles, if the temperature increases above the cloud point (CPT) the micelles become dehydrated and aggregate. This leads to macroscopic phase separation of the solution into a surfactant-rich phase and a solvent phase." ;
rdfs:subClassOf obo:CHMO_0001600 .
obo:CHEBI_23240 a rdfs:Class ;
rdfs:label "chromophore" ;
rdfs:comment "The part (atom or group of atoms) of a molecular entity in which the electronic transition responsible for a given spectral band is approximately localized." ;
rdfs:subClassOf obo:CHEBI_52215 .
a rdfs:Class ;
rdfs:label "ingredient role" ;
rdfs:comment "Ingredient is a role of material that is used in a material combining process to produce a new material. [Allotrope]" ;
rdfs:subClassOf .
obo:CHEBI_22951 a rdfs:Class ;
rdfs:label "butanone" ;
rdfs:comment "Any ketone that is butane substituted by an oxo group at unspecified position." ;
rdfs:subClassOf obo:CHEBI_17087 .
obo:CHMO_0001655 a rdfs:Class ;
rdfs:label "high-speed ball milling" ;
rdfs:comment "The mechanical reduction of the particle size of a solid sample by grinding with one or more inert balls (ceramic, flint or stainless steel, 2–8 mm diameter) rotating at high speed around a horizontal axis. A high-speed agitator is used to increase the speed of the balls." ;
rdfs:subClassOf obo:CHMO_0001654 .
obo:OBI_0500000 a rdfs:Class ;
rdfs:label "study design"@en ;
rdfs:comment "A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution." ;
rdfs:subClassOf obo:IAO_0000104 .
obo:PROCO_0000179 a rdfs:Class ;
rdfs:label "Liebig condenser"@en ;
rdfs:comment "A condensor consisting of a simple tube surrounded by a jacket of cooling water" ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:CHEBI_48378 a rdfs:Class ;
rdfs:label "carboximidic acid" ;
rdfs:subClassOf obo:CHEBI_35352 , obo:CHEBI_48377 .
a rdf:Property ;
rdfs:label "has functional parent" ;
rdfs:range .
obo:PROCO_0000139 a rdfs:Class ;
rdfs:label "crystalline solid thermodynamic phase"@en ;
rdfs:comment "A crystalline phase is a single solid crystalline thermodynamic phase" ;
rdfs:subClassOf obo:PROCO_0000138 .
obo:CHEBI_24833 a rdfs:Class ;
rdfs:label "oxoacid" ;
rdfs:comment "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." ;
rdfs:subClassOf obo:CHEBI_24651 .
obo:CHEBI_52215 a rdfs:Class ;
rdfs:label "photochemical role" ;
rdfs:comment "A chemical role played by the molecular entity or part thereof in a photochemical process." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:OBI_0001554 a rdfs:Class ;
rdfs:label "rate measurement datum" ;
rdfs:comment "A scalar measurement datum that represents the number of events occuring over a time interval" ;
rdfs:subClassOf obo:IAO_0000032 .
obo:IAO_0000004 a rdf:Property ;
rdfs:label "has measurement value"@en ;
rdfs:domain obo:IAO_0000032 ;
rdfs:range xsd:double .
obo:IAO_0000039 a rdf:Property ;
rdfs:label "has measurement unit label"@en ;
rdfs:range obo:IAO_0000003 ;
rdfs:subPropertyOf obo:BFO_0000051 .
obo:CHMO_0001696 a rdfs:Class ;
rdfs:label "postprecipitation" ;
rdfs:comment "The subsequent precipitation of a chemically different species upon the surface of an initial precipitate usually, but not necessarily, including a common ion." ;
rdfs:subClassOf obo:CHMO_0001688 .
obo:CHEBI_25384 a rdfs:Class ;
rdfs:label "monocarboxylic acid" ;
rdfs:comment "An oxoacid containing a single carboxy group." ;
rdfs:subClassOf obo:CHEBI_33575 .
obo:PROCO_0000219 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.2.4 Controls of Critical Steps and Intermediates" ;
rdfs:comment """The document part of the common technical document that specifies tests and acceptance criteria (with justification including experimental data) performed at critical steps identified in 3.2.S.2.2 of the manufacturing process to ensure that the process is controlled. Information on the quality and control of intermediates isolated during the process is also provided.
Reference ICH guidances Q6A and Q6B.""" ;
rdfs:subClassOf obo:IAO_0000314 .
obo:CHEBI_33658 a rdfs:Class ;
rdfs:label "arene" ;
rdfs:comment "Any monocyclic or polycyclic aromatic hydrocarbon." ;
rdfs:subClassOf obo:CHEBI_33659 , obo:CHEBI_33663 .
obo:PROCO_0000276 a rdfs:Class ;
rdfs:label "experimental design" ;
rdfs:comment "The design of an experiment intended to test a hypothesis, and describe or explain empirical data obtained under various experimental conditions." ;
rdfs:subClassOf obo:IAO_0000104 .
obo:CHMO_0002771 a rdfs:Class ;
rdfs:label "concentrating" ;
rdfs:comment "A preparative step where the concentration of one component is increased." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:PROCO_0000133 a rdfs:Class ;
rdfs:label "unit cell Z value"@en ;
rdfs:comment "A unit cell quality indicating the number of formula units (molecules) in the unit cell" ;
rdfs:subClassOf obo:PROCO_0000109 .
a rdfs:Class ;
rdfs:label "classification" ;
rdfs:comment "A classification is a proposition that categorizes things into classes or collections of things differentiated by some criteria. [Allotrope]" ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHEBI_51422 a rdfs:Class ;
rdfs:label "organodiyl group" ;
rdfs:comment "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." ;
rdfs:subClassOf obo:CHEBI_51446 .
obo:PROCO_0000197 a rdfs:Class ;
rdfs:label "evaporation device"@en ;
rdfs:comment "A device that evaporates" ;
rdfs:subClassOf .
obo:PROCO_0000208 a rdfs:Class ;
rdfs:label "molecular formula"@en ;
rdfs:comment "A molecular entity quality which identifies each constituent element by its chemical symbol and indicates the number of atoms of each element found in each discrete molecular entity of that compound." ;
rdfs:subClassOf obo:PATO_0002182 .
obo:CHEBI_36587 a rdfs:Class ;
rdfs:label "organic oxo compound" ;
rdfs:comment "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." ;
rdfs:subClassOf obo:CHEBI_72695 .
obo:CHEBI_52208 a rdfs:Class ;
rdfs:label "biophysical role" ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:PROCO_0000034 a rdfs:Class ;
rdfs:label "temperature measurement"@en ;
rdfs:comment "A process measurement of the temperature in a process" ;
rdfs:subClassOf obo:PROCO_0000100 .
obo:PROCO_0000118 a rdfs:Class ;
rdfs:label "unit cell b-axis length"@en ;
rdfs:comment "the length of the b-axis of a unit cell"@en ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:CHMO_0001542 a rdfs:Class ;
rdfs:label "molecular distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a high-boiling-point sample mixture are vaporised by the application of heat at low pressure (< 0.01 Torr) and then cooled by the action of cold water in a condenser." ;
rdfs:subClassOf obo:CHMO_0001540 .
obo:PROCO_0000089 a rdfs:Class ;
rdfs:label "polymorph and solvate screening design"@en ;
rdfs:comment "A screening design to discover polymorphs and solvates of a compound" ;
rdfs:subClassOf obo:PROCO_0000091 .
obo:PROCO_0000294 a rdfs:Class ;
rdfs:label "calculated datum" ;
rdfs:comment "A data item that is a recording of the output of a calculation." ;
rdfs:subClassOf obo:IAO_0000027 .
obo:CHEBI_33595 a rdfs:Class ;
rdfs:label "cyclic compound" ;
rdfs:comment "Any molecule that consists of a series of atoms joined together to form a ring." ;
rdfs:subClassOf obo:CHEBI_25367 .
obo:PROCO_0000251 a rdfs:Class ;
rdfs:label "tetragonal-scalenohedral" ;
rdfs:comment "8-faced (tetragonal) or 12-faced (hexagonal) closed tetragonal form with non-centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHMO_0001464 a rdfs:Class ;
rdfs:label "ageing" ;
rdfs:comment "Any time-dependent change of the properties of a precipitate e.g. loss of water or growth of crystals as a result of prolonged heat treatment." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:CHEBI_59941 a rdfs:Class ;
rdfs:label "amphiphile" ;
rdfs:comment "A surfactant molecule possessing both hydrophilic and lipophilic properties." ;
rdfs:subClassOf obo:CHEBI_35195 .
a rdfs:Class ;
rdfs:label "additive role" ;
rdfs:comment "Additive is a role of material that is added to a mixture in order to achieve a supportive purpose. [Allotrope]" ;
rdfs:subClassOf , .
obo:PROCO_0000153 a rdfs:Class ;
rdfs:label "pedial"@en ;
rdfs:comment "An open,one faced triclinic form with enantiomorphic and polar point symmetries" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_63064 a rdfs:Class ;
rdfs:label "crystallisation adjutant" ;
rdfs:comment "Chemical role played by a material when used to promote crystallisation." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:PROCO_0000262 a rdfs:Class ;
rdfs:label "dihexagonal-pyramidal" ;
rdfs:comment "12-faced hexagonal crystal where all faces are related by a 6-fold axis. It has polar point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHMO_0001553 a rdfs:Class ;
rdfs:label "freeze drying" ;
rdfs:comment "The removal of solvent from a sample without passing through the liquid–gas boundary. The sample is frozen at liquid nitrogen temperature (-80 °C) then the surrounding pressure is reduced to allow the water in the sample to sublime." ;
rdfs:subClassOf obo:CHMO_0001549 .
obo:PROCO_0000287 a rdfs:Class ;
rdfs:label "material costs" ;
rdfs:comment "A process chemistry datum quantifying the sum of the costs of all raw materials, intermediates, reagents, solvents and catalysts procured from external vendor." ;
rdfs:subClassOf obo:PROCO_0000295 .
obo:CHMO_0002223 a rdfs:Class ;
rdfs:label "sandwich sublimation" ;
rdfs:comment "A technique for growing thick (micrometre) epitaxial layers of SiC by heating a source (polycrystalline SiC or powder) at high temperature (1800-2600 °C) and low pressure in an Ar atmosphere causing it to sublime. The vapours then condense on a single crystal of SiC (the 'seed') placed a few mm away." ;
rdfs:subClassOf obo:CHMO_0002222 .
obo:CHMO_0001644 a rdfs:Class ;
rdfs:label "suction filtration" ;
rdfs:comment "The separation of a solid phase from a liquid phase by passing the sample through a porous medium under pressure." ;
rdfs:subClassOf obo:CHMO_0001640 .
obo:OBI_0000047 a rdfs:Class ;
rdfs:label "processed material"@en ;
rdfs:comment "Is a material entity that is created or changed during material processing."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:OBI_0000312 a rdf:Property ;
rdfs:label "is_specified_output_of"@en ;
rdfs:comment "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
rdfs:domain obo:BFO_0000002 ;
rdfs:range obo:OBI_0000011 ;
rdfs:subPropertyOf obo:RO_0000056 .
obo:PROCO_0000144 a rdfs:Class ;
rdfs:label "solvate"@en ;
rdfs:comment "A solvate is a crystalline material that has solvent molecules incorporated into the crystal lattice in a stoichiometric amount. [Allotrope]" ;
rdfs:subClassOf obo:PROCO_0000142 .
obo:CHEBI_33842 a rdfs:Class ;
rdfs:label "aromatic annulene" ;
rdfs:subClassOf obo:CHEBI_33662 , obo:CHEBI_33847 .
obo:CHEBI_17790 a rdfs:Class ;
rdfs:label "methanol" ;
rdfs:comment "The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_15734 , obo:CHEBI_50584 , obo:CHEBI_64708 .
a rdfs:Class ;
rdfs:label "representation form" ;
rdfs:comment "A representation form is a type of information content entity that represents an entity in a certain way. [Allotrope]" ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHMO_0002217 a rdfs:Class ;
rdfs:label "sample sublimation" ;
rdfs:comment "Any technique used to purify a sample by forcing it to pass from the solid to gas phase without passing through an intermediate liquid phase." ;
rdfs:subClassOf obo:CHMO_0002231 .
obo:CHEBI_37176 a rdfs:Class ;
rdfs:label "mononuclear parent hydride" ;
rdfs:subClassOf obo:CHEBI_33692 .
obo:CHEBI_33306 a rdfs:Class ;
rdfs:label "carbon group element atom" ;
rdfs:subClassOf obo:CHEBI_33560 .
obo:CHMO_0000993 a rdfs:Class ;
rdfs:label "portion of material" ;
rdfs:comment "An independent material continuant that is self-connected and retains its identity over time." ;
rdfs:subClassOf obo:BFO_0000040 .
a rdfs:Class ;
rdfs:label "changing" ;
rdfs:comment "Changing is a processing by which an entity gains or looses parts, qualities, roles, dispositions, functions etc in a predetermined and fixed manner but maintains its identity. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000127 a rdfs:Class ;
rdfs:label "monoclinic unit cell"@en ;
rdfs:comment "A unit cell that has three axes of unequal length, two of which are perpendicular" ;
rdfs:subClassOf obo:PROCO_0000120 .
obo:CHEBI_28398 a rdfs:Class ;
rdfs:label "butan-2-one" ;
rdfs:comment "A dialkyl ketone that is a four-carbon ketone carrying a single keto- group at position C-2." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_18044 , obo:CHEBI_22951 , obo:CHEBI_51867 .
obo:PROCO_0000056 a rdfs:Class ;
rdfs:label "route specification"@en ;
rdfs:comment "A sequenced plan of synthetic steps and defined intermediates to make a specific product from commercially available starting materials" ;
rdfs:subClassOf obo:IAO_0000104 .
obo:PROCO_0000128 a rdfs:Class ;
rdfs:label "triclinic unit cell"@en ;
rdfs:comment "A unit cell in which all axes are of different length and no angle is perpendicular nor equal to any other angles." ;
rdfs:subClassOf obo:PROCO_0000120 .
obo:PROCO_0000137 a rdfs:Class ;
rdfs:label "habit"@en ;
rdfs:comment "A description of one of the characteristic external shapes (crystal class / point group) of an individual crystal family / system. Factors that impact growth rates on the various crystal faces produce different shapes but possess the same set of symmetry elements as parent crystal class." ;
rdfs:subClassOf obo:PATO_0000051 .
obo:CHMO_0002775 a rdfs:Class ;
rdfs:label "magnetic stirring" ;
rdfs:comment "Stirring achieved by rotating a magnetic stir bar in a solution." ;
rdfs:subClassOf obo:CHMO_0002774 .
obo:CHMO_0002466 a rdfs:Class ;
rdfs:label "protein precipitation" ;
rdfs:comment "The sedimentation of a solid protein (a 'precipitate') from an aqueous solution caused by the addition of an organic solvent (e.g. methanol), a polyelectrolyte (e.g. alginate) or a salt (e.g. ammonium sulfate) in a process known as 'salting out'." ;
rdfs:subClassOf obo:CHMO_0001688 .
obo:PROCO_0000272 a rdfs:Class ;
rdfs:label "ICH Q6A Class 2 Solvent" ;
rdfs:comment "Solvents to be limited non-genotoxic animal carcinogens or possible causative agents of other irreversible toxicity such as neurotoxicity or teratogenicity. Solvents suspected of other significant but reversible toxicities" ;
rdfs:subClassOf obo:PROCO_0000270 .
obo:PROCO_0000263 a rdfs:Class ;
rdfs:label "ditrigonal-dipyramidal" ;
rdfs:comment "12-faced form tetragonal crystal class with non-centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_36586 a rdfs:Class ;
rdfs:label "carbonyl compound" ;
rdfs:comment "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." ;
rdfs:subClassOf obo:CHEBI_36587 , obo:CHEBI_36963 .
obo:CHMO_0001006 a rdfs:Class ;
rdfs:label "affinity chromatography" ;
rdfs:comment "Chromatography where the separation is caused by differing biological specificity of the analyte-ligand interactions." ;
rdfs:subClassOf obo:CHMO_0001001 .
obo:BFO_0000057 a rdf:Property ;
rdfs:label "has participant" ;
rdfs:range .
obo:CHEBI_35757 a rdfs:Class ;
rdfs:label "monocarboxylic acid anion" ;
rdfs:comment "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." ;
rdfs:subClassOf obo:CHEBI_29067 .
a rdf:Property ;
rdfs:label "is conjugate base of" ;
rdfs:range .
a rdfs:Class ;
rdfs:label "unspecified degradation product role" ;
rdfs:comment "A degradation product role that is limited by a general acceptance criterion, but not individually listed with its own specific acceptance criterion, in the new drug product specification. [ICH-Q3A]" ;
rdfs:subClassOf , .
obo:CHEBI_38161 a rdfs:Class ;
rdfs:label "chelator" ;
rdfs:comment "A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate." ;
rdfs:subClassOf obo:CHEBI_52214 .
obo:PROCO_0000168 a rdfs:Class ;
rdfs:label "overall assessed purge factor" ;
rdfs:comment "The assessed ratio of maximum possible concentration before purging to its concentration after purging (the final product). It is simply the product of all the assessed purge factors of each reaction step to which the impurity is subjected." ;
rdfs:subClassOf obo:PROCO_0000070 .
a rdfs:Class ;
rdfs:label "cleaning role" ;
rdfs:comment "The role of a participant of a cleaning process. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:CHMO_0002011 a rdfs:Class ;
rdfs:label "sequential centrifugation" ;
rdfs:comment "A separation method where the components of a sample are separated on the basis of their density in a centrifuge according to the centrifugal force they experience. The sample is centrifuged in a number of separate, sequential steps." ;
rdfs:subClassOf obo:OBI_0302886 .
obo:CHMO_0001479 a rdfs:Class ;
rdfs:label "fractional crystallisation" ;
rdfs:comment "The stepwise crystallisation of two or more different substances induced by changes in concentration or temperature. The sample is mixed with a solvent, heated, and then gradually cooled so that, as each of its constituent components crystallises, it can be removed in its pure form from the solution." ;
rdfs:subClassOf obo:CHMO_0001477 .
a rdfs:Class ;
rdfs:label "chemical substance quality" ;
rdfs:comment "A chemical substance quality is a quality that inheres in some portion of chemical substance. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000019 .
obo:OBI_0000968 a rdfs:Class ;
rdfs:label "device" ;
rdfs:comment "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent." ;
rdfs:subClassOf obo:CHMO_0000993 , obo:OBI_0000047 .
obo:PROCO_0000009 a rdfs:Class ;
rdfs:label "route scouting"@en ;
rdfs:comment "A process of systematically selecting possible synthetic routes to make a particular product or intermediate." ;
rdfs:subClassOf obo:PROCO_0000099 .
obo:PROCO_0000175 a rdfs:Class ;
rdfs:label "Vigreux column"@en ;
rdfs:comment "A fractionating column made of a wide glass tube with multiple internal glass \"fingers\" that point downwards so that the vapor that enters from the lower opening condenses on the fingers and drips down from them." ;
rdfs:subClassOf obo:PROCO_0000174 .
obo:PROCO_0000283 a rdfs:Class ;
rdfs:label "master formula record" ;
rdfs:comment """A plan specification of manufacturing instructions for a specific (unique) batch and includes: specific instructions for each step, the equipment used in each step, sampling and testing procedures for each step, the amount of each component needed to manufacture the batch (Bill of Materials) and the theoretical yield and expected yield of each intermediate as well as the product.
.""" ;
rdfs:subClassOf obo:PROCO_0000093 .
a rdfs:Class ;
rdfs:label "extraneous contaminant role" ;
rdfs:comment "An extraneous contaminant role is an impurity role arising from any source extraneous to the manufacturing process. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:PROCO_0000026 a rdfs:Class ;
rdfs:label "commercial chemical product"@en ;
rdfs:comment "A chemical product that is used for commercial purpose." ;
rdfs:subClassOf obo:PROCO_0000025 .
obo:PROCO_0000185 a rdfs:Class ;
rdfs:label "cold finger"@en ;
rdfs:comment "A condensor consisting of a vertical rod that is flow-cooled from the inside that is to be immersed in the vapor to provide a condensing surface. This condensor is also used for sublimation." ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:CHEBI_77963 a rdfs:Class ;
rdfs:label "sequestrant" ;
rdfs:comment "A food preservative that acts by chelating with metal cations (particularly those of copper, iron and nickel) that catalyse the oxidation of fats in food." ;
rdfs:subClassOf obo:CHEBI_38161 , obo:CHEBI_65255 .
obo:CHMO_0001465 a rdfs:Class ;
rdfs:label "annealing" ;
rdfs:comment "A heat treatment that alters the microstructure of a material causing changes in its properties such as strength and hardness" ;
rdfs:subClassOf obo:CHMO_0002770 .
obo:CHEBI_22712 a rdfs:Class ;
rdfs:label "benzenes" ;
rdfs:comment "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." ;
rdfs:subClassOf obo:CHEBI_33836 .
obo:CHEBI_16716 a rdfs:Class ;
rdfs:label "benzene" ;
rdfs:comment "A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_22712 , obo:CHEBI_33842 .
obo:IAO_0000314 a rdfs:Class ;
rdfs:label "document part"@en ;
rdfs:comment "An information content entity that is part of a document."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHMO_0001301 a rdfs:Class ;
rdfs:label "synthesis method" ;
rdfs:comment "A method used to synthesise a sample." ;
rdfs:subClassOf obo:OBI_0000094 .
obo:PROCO_0000186 a rdfs:Class ;
rdfs:label "Frederichs condensor"@en ;
rdfs:comment "A condensor consisting of a large water-cooled finger tightly fitted inside a wide cylindrical housing. The finger has a helical ridge along its length, so as to leave a narrow helical path for the vapor." ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:CHMO_0002224 a rdfs:Class ;
rdfs:label "crystal growth method" ;
rdfs:comment "Any synthesis method used to grow crystals." ;
rdfs:subClassOf obo:CHMO_0001310 .
obo:PROCO_0000148 a rdfs:Class ;
rdfs:label "isomorphic desolvate"@en ;
rdfs:comment "An anhydrous crystalline phase formed experimentally by removing the solvent from a solvate" ;
rdfs:subClassOf obo:PROCO_0000147 .
obo:PROCO_0000252 a rdfs:Class ;
rdfs:label "ditetragonal-dipyramidal" ;
rdfs:comment "16-faced form tetragonal crystal form with centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000157 a rdfs:Class ;
rdfs:label "hextetrahedral"@en ;
rdfs:comment "A cubic system crystal class with 24-faces and four fold rotoinversion axes and non-centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000266 a rdfs:Class ;
rdfs:label "ICH Q3C Residual Solvents" ;
rdfs:comment """An ICH guideline for the use residual solvents (organic volatile impurities)
in the manufacture of drug substances and dosage forms, and sets pharmaceutical limits for in drug products.""" ;
rdfs:subClassOf obo:PROCO_0000136 .
obo:CHEBI_33575 a rdfs:Class ;
rdfs:label "carboxylic acid" ;
rdfs:comment "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." ;
rdfs:subClassOf obo:CHEBI_35605 , obo:CHEBI_36586 , obo:CHEBI_64709 .
obo:PROCO_0000070 a rdfs:Class ;
rdfs:label "purge factor"@en ;
rdfs:comment "A process chemistry datum that quantifies the ratio of the amount of an impurity in the waste stream of a process to that retained in the product stream." ;
rdfs:subClassOf obo:PROCO_0000295 .
obo:CHMO_0001607 a rdfs:Class ;
rdfs:label "solid–liquid extraction" ;
rdfs:comment "The process of transferring the soluble components of a solid to the liquid phase using a solvent." ;
rdfs:subClassOf obo:CHMO_0001598 .
obo:CHMO_0001535 a rdfs:Class ;
rdfs:label "extractive distillation" ;
rdfs:comment "A method of separating two components of very similar boiling point from a mixture. A third, miscible and high-boiling-point solvent is added to the mixture which causes a change in the volatilities of the components. These components are then vaporised by the application of heat and cooled by the action of cold water in a condenser." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:PROCO_0000255 a rdfs:Class ;
rdfs:label "trigonal-trapezohedral" ;
rdfs:comment "6-, 8-, 12-, or 24-trapezohedral faced closed trigonal form with enantiomorphic point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_29347 a rdfs:Class ;
rdfs:label "monocarboxylic acid amide" ;
rdfs:comment "A carboxamide derived from a monocarboxylic acid." ;
rdfs:subClassOf obo:CHEBI_37622 .
obo:PROCO_0000067 a rdfs:Class ;
rdfs:label "precipitate role"@en ;
rdfs:comment "The role of solids in a slurry" ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_78299 a rdfs:Class ;
rdfs:label "environmental food contaminant" ;
rdfs:comment "Any unwanted chemical in food. The term includes agrochemicals and industrial chemicals that may contaminate foodstuffs during their production, transportation or storage." ;
rdfs:subClassOf obo:CHEBI_78295 , obo:CHEBI_78298 .
obo:PROCO_0000138 a rdfs:Class ;
rdfs:label "thermodynamic phase"@en ;
rdfs:comment "A portion of material within a a region of space in a system throughout which all physical properties of the material are essentially uniform." ;
rdfs:subClassOf obo:CHMO_0000993 .
obo:CHEBI_77523 a rdfs:Class ;
rdfs:label "Maillard reaction product" ;
rdfs:comment "Any thermal degradation product obtained as a result of a chemical reaction between an amino acid and a reducing sugar (Maillard reaction, a non-enzymatic browning procedure that usually imparts flavour to starch-based food products)." ;
rdfs:subClassOf obo:CHEBI_77521 .
obo:CHMO_0001550 a rdfs:Class ;
rdfs:label "dielectric drying" ;
rdfs:comment "The removal of solvent from a sample by the application of radio frequency (3 Hz to 300 GHz) or microwave (1–1000 mm) radiation." ;
rdfs:subClassOf obo:CHMO_0001549 .
obo:CHEBI_38104 a rdfs:Class ;
rdfs:label "oxacycle" ;
rdfs:comment "Any organic heterocyclic compound containing at least one ring oxygen atom." ;
rdfs:subClassOf obo:CHEBI_24532 , obo:CHEBI_36963 .
obo:PROCO_0000107 a rdfs:Class ;
rdfs:label "assessed reactivity purge factor" ;
rdfs:comment "The assessed reactivity of the mutagenic impurity in the processing conditions" ;
rdfs:subClassOf obo:BFO_0000144 , obo:PROCO_0000070 .
obo:PROCO_0000027 a rdf:Property ;
rdfs:label "profile of"@en ;
rdfs:comment "a relationship indicating that the process profile quantitates some aspect of the process (e.g. a quality of a material participant)" ;
rdfs:domain obo:BFO_0000144 ;
rdfs:range .
obo:CHEBI_17499 a rdfs:Class ;
rdfs:label "hydrogen donor" ;
rdfs:comment "A molecular entity that can undergo oxidation by the loss of hydrogen atom(s)." ;
rdfs:subClassOf obo:CHEBI_15022 .
obo:CHEBI_36828 a rdfs:Class ;
rdfs:label "pseudohalide anion" ;
rdfs:subClassOf obo:CHEBI_36829 .
obo:CHMO_0002652 a rdfs:Class ;
rdfs:label "chemical vapour transport" ;
rdfs:comment "A crystal growth method for metal dichalcogenides in which the starting materials (high purity metal and chalcogen) are placed in a quartz ampoule together with a transport agent (e.g. iodine) and heated in a furnace under a temperature gradient." ;
rdfs:subClassOf obo:CHMO_0002224 .
obo:PROCO_0000014 a rdfs:Class ;
rdfs:label "experiment"@en ;
rdfs:comment "An investigation carried out to support or refute a hypothesis. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated." ;
rdfs:subClassOf obo:OBI_0000066 .
obo:CHMO_0001575 a rdfs:Class ;
rdfs:label "centrifugal evaporation" ;
rdfs:comment "The evaporation of solvent from a sample by placing it a centrifuge and spinning it rapidly." ;
rdfs:subClassOf obo:CHMO_0002208 .
obo:CHEBI_75763 a rdfs:Class ;
rdfs:label "eukaryotic metabolite" ;
rdfs:comment "Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." ;
rdfs:subClassOf obo:CHEBI_25212 .
obo:PROCO_0000121 a rdfs:Class ;
rdfs:label "cubic unit cell"@en ;
rdfs:comment """A unit cell that has three perpendicular axes of equal lengths.
equivalent to ENM:9000035""" ;
rdfs:subClassOf obo:PROCO_0000120 .
obo:PROCO_0000051 a rdfs:Class ;
rdfs:label "unit operation in chemical processing"@en ;
rdfs:comment "A basic and unit step in a process" ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHMO_0002220 a rdfs:Class ;
rdfs:label "high-vacuum sublimation" ;
rdfs:comment "A technique for purifying solid samples by heating the sample under high vacuum (<0.1 Pa). The sample sublimes and the vapours condense as a purified compound on a cooled surface, leaving the non-volatile residue impurities behind." ;
rdfs:subClassOf obo:CHMO_0002219 .
obo:CHEBI_39143 a rdfs:Class ;
rdfs:label "Lewis acid" ;
rdfs:comment "A molecular entity that is an electron-pair acceptor and therefore able to form a covalent bond with an electron-pair donor (Lewis base), thereby producing a Lewis adduct." ;
rdfs:subClassOf obo:CHEBI_15339 , obo:CHEBI_37527 .
obo:PROCO_0000247 a rdfs:Class ;
rdfs:label "tetragonal-disphenoidal" ;
rdfs:comment "4-faced closed orthorhombic form with non-centrosymmetric point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHMO_0000999 a rdfs:Class ;
rdfs:label "separation method" ;
rdfs:comment "A method that results in the separation of two or more components according to some property." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:CHEBI_36963 a rdfs:Class ;
rdfs:label "organooxygen compound" ;
rdfs:comment "An organochalcogen compound containing at least one carbon-oxygen bond." ;
rdfs:subClassOf obo:CHEBI_25806 , obo:CHEBI_36962 .
obo:CHEBI_33273 a rdfs:Class ;
rdfs:label "polyatomic anion" ;
rdfs:comment "An anion consisting of more than one atom." ;
rdfs:subClassOf obo:CHEBI_22563 , obo:CHEBI_36358 .
obo:CHMO_0002231 a rdfs:Class ;
rdfs:label "purification" ;
rdfs:comment "Any technique used to physically separate an analyte from byproducts, reagents or contaminating substances." ;
rdfs:subClassOf obo:CHMO_0000999 .
obo:CHEBI_46883 a rdfs:Class ;
rdfs:label "carboxy group" ;
rdfs:subClassOf obo:CHEBI_33249 .
obo:CHEBI_24028 a rdfs:Class ;
rdfs:label "iron(3+) chelator" ;
rdfs:subClassOf obo:CHEBI_38157 .
obo:PROCO_0000102 a rdfs:Class ;
rdfs:label "end reaction monitoring"@en ;
rdfs:comment "A process monitoring to determine when a chemical reaction has ended." ;
rdfs:subClassOf obo:PROCO_0000100 .
obo:PROCO_0000110 a rdfs:Class ;
rdfs:label "space group"@en ;
rdfs:comment "a symmetry quality of a unit cell in three-dimensional space."@en ;
rdfs:subClassOf obo:PATO_0000965 , obo:PROCO_0000109 .
obo:CHEBI_33670 a rdfs:Class ;
rdfs:label "heteromonocyclic compound" ;
rdfs:subClassOf obo:CHEBI_33661 , obo:CHEBI_5686 .
obo:CHEBI_75771 a rdfs:Class ;
rdfs:label "mouse metabolite" ;
rdfs:comment "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." ;
rdfs:subClassOf obo:CHEBI_75768 .
a rdfs:Class ;
rdfs:label "batch role" ;
rdfs:comment "Batch role is a product role of a portion of material that is intended to have uniform character and quality, within specified limits, and is produced according to a single manufacturing order during the same cycle of manufacture. [Allotrope, CFR21]" ;
rdfs:subClassOf .
obo:PROCO_0000015 a rdfs:Class ;
rdfs:label "process profile specification"@en ;
rdfs:comment "A directive information entity that specifies allowed ranges recorded for a process profile." ;
rdfs:subClassOf obo:IAO_0000033 .
obo:CHEBI_30751 a rdfs:Class ;
rdfs:label "formic acid" ;
rdfs:comment "The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects." ;
rdfs:subClassOf obo:CHEBI_25384 .
obo:CHEBI_33284 a rdfs:Class ;
rdfs:label "nutrient" ;
rdfs:comment "A nutrient is a food component that an organism uses to survive and grow." ;
rdfs:subClassOf obo:CHEBI_78295 .
obo:PROCO_0000204 a rdfs:Class ;
rdfs:label "chemical abstracts number"@en ;
rdfs:comment "A centrally registered identifier assigned by the Chemical Abstracts Service (CAS) to every chemical substance described in the open scientific literature." ;
rdfs:subClassOf obo:IAO_0000578 .
obo:CHMO_0001532 a rdfs:Class ;
rdfs:label "distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a sample mixture are vaporised by the application of heat and then cooled by the action of cold water in a condenser." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
a rdfs:Class ;
rdfs:label "material dried role" ;
rdfs:comment "Material dried role is the drying role of the material being dried. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000095 a rdfs:Class ;
rdfs:label "product filing documentation"@en ;
rdfs:comment "A document to secure permission or continuing permission to market a product from a regulatory body." ;
rdfs:subClassOf obo:IAO_0000310 .
obo:PROCO_0000236 a rdfs:Class ;
rdfs:label "graphical rate equation" ;
rdfs:comment "A plot of the differential kinetic measurement as the y-axis vs. the integral measurement as the x-axis." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "activity" ;
rdfs:comment "An activity is a process that is cumulative but not homomeric. [Allotrope, DOLCE]" ;
rdfs:subClassOf obo:BFO_0000015 .
obo:PATO_0002182 a rdfs:Class ;
rdfs:label "molecular quality" ;
rdfs:comment "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." ;
rdfs:subClassOf obo:PATO_0000001 .
obo:CHEBI_59739 a rdfs:Class ;
rdfs:label "electrophilic reagent" ;
rdfs:comment "A reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner." ;
rdfs:subClassOf obo:CHEBI_33893 , obo:CHEBI_39143 .
obo:IAO_0000028 a rdfs:Class ;
rdfs:label "symbol"@en ;
rdfs:comment "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:BFO_0000040 a rdfs:Class ;
rdfs:label "material entity" ;
rdfs:comment "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ;
rdfs:subClassOf obo:BFO_0000004 .
a rdfs:Class ;
rdfs:label "exponential time constant" ;
rdfs:comment "Synonym: mean lifetime " ;
rdfs:subClassOf , .
obo:GO_0034061 a rdfs:Class ;
rdfs:label "DNA polymerase activity" ;
rdfs:comment "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group." ;
rdfs:subClassOf obo:GO_0003824 .
obo:CHMO_0001583 a rdfs:Class ;
rdfs:label "liquid-solid extraction" ;
rdfs:comment "The process of transferring a substance from a liquid to a solid phase by passing the liquid sample through a stationary phase (e.g. silica particles)." ;
rdfs:subClassOf obo:CHMO_0001577 .
obo:CHEBI_33692 a rdfs:Class ;
rdfs:label "hydrides" ;
rdfs:comment "Hydrides are chemical compounds of hydrogen with other chemical elements." ;
rdfs:subClassOf obo:CHEBI_33608 , obo:CHEBI_37577 .
obo:PROCO_0000143 a rdfs:Class ;
rdfs:label "co-crystal"@en ;
rdfs:comment "A co-crystal is a solid solution and a molecular complex with two or more non-solvent molecules incorporated into the unit cell in a stoichiometric amount." ;
rdfs:subClassOf obo:PROCO_0000142 .
obo:PROCO_0000211 a rdfs:Class ;
rdfs:label "certificate of analysis"@en ;
rdfs:comment "A document certified by a vendor summarizing test results and specifications for a particular batch of its product." ;
rdfs:subClassOf obo:IAO_0000310 .
obo:CHMO_0001129 a rdfs:Class ;
rdfs:label "displacement chromatography" ;
rdfs:comment "Chromatography where the mobile phase contains a compound (the displacer) more strongly retained than the components of the sample under examination. The sample is fed into the system as a finite slug." ;
rdfs:subClassOf obo:CHMO_0001000 .
obo:CHEBI_35942 a rdfs:Class ;
rdfs:label "neurotransmitter agent" ;
rdfs:comment "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." ;
rdfs:subClassOf obo:CHEBI_23888 , obo:CHEBI_52210 .
obo:CHEBI_35552 a rdfs:Class ;
rdfs:label "heterocyclic organic fundamental parent" ;
rdfs:subClassOf obo:CHEBI_33245 .
obo:PROCO_0000222 a rdfs:Class ;
rdfs:label "ICH M7 Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals To Limit Potential Carcinogenic Risk" ;
rdfs:comment """An ICH guideline and objective specification for the
identification, categorization, qualification, and control of these mutagenic impurities in pahrmaceutical products to limit potential carcinogenic risk.""" ;
rdfs:subClassOf obo:PROCO_0000136 .
obo:CHMO_0001947 a rdfs:Class ;
rdfs:label "precipitation with compressed antisolvent" ;
rdfs:comment "A technique where a solid sample is dissolved in a common (organic or inorganic) solvent then sprayed into a vessel pressurised with a dense gas (e.g. supercritical CO2) This results in a large decrease in solution density and precipitation." ;
rdfs:subClassOf obo:CHMO_0001905 .
obo:CHEBI_50860 a rdfs:Class ;
rdfs:label "organic molecular entity" ;
rdfs:comment "Any molecular entity that contains carbon." ;
rdfs:subClassOf obo:CHEBI_33582 .
a rdfs:Class ;
rdfs:label "formulation role" ;
rdfs:comment "A formulation role is a role of a material that is participating in a formulation process. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000149 a rdfs:Class ;
rdfs:label "eutectic"@en ;
rdfs:comment "A heterogeneous ensemble of individual components whose crystal structures are like discontinuous solid solutions (phase separated)." ;
rdfs:subClassOf obo:PROCO_0000074 , .
obo:CHEBI_28616 a rdfs:Class ;
rdfs:label "carbamic acid" ;
rdfs:comment "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." ;
rdfs:subClassOf obo:CHEBI_35352 , obo:CHEBI_35605 , obo:CHEBI_64708 .
obo:CHEBI_2571 a rdfs:Class ;
rdfs:label "aliphatic alcohol" ;
rdfs:comment "An alcohol derived from an aliphatic compound." ;
rdfs:subClassOf obo:CHEBI_30879 .
a rdfs:Class ;
rdfs:label "liquid" ;
rdfs:comment "A state of matter that is a nearly incompressible fluid that conforms to the shape of its container but retains a (nearly) constant volume independent of pressure. [Wikipedia]" ;
rdfs:subClassOf .
obo:PROCO_0000002 a rdfs:Class ;
rdfs:label "Plackett–Burman design"@en ;
rdfs:comment "An experimental design to limit the number of experiments covering the space by assuming the Interactions between the factors are negligible" ;
rdfs:subClassOf obo:PROCO_0000276 .
obo:CHEBI_75767 a rdfs:Class ;
rdfs:label "animal metabolite" ;
rdfs:comment "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." ;
rdfs:subClassOf obo:CHEBI_75763 .
obo:CHMO_0002742 a rdfs:Class ;
rdfs:label "elution" ;
rdfs:comment "A process wherein one material is extracted from another by interaction with a solvent." ;
rdfs:subClassOf obo:CHMO_0001577 .
a rdfs:Class ;
rdfs:label "reactant role" ;
rdfs:comment "Reactant role is a role of a chemical entity that is present at the start of a reaction. [Allotrope]" ;
rdfs:subClassOf obo:OBI_0000086 .
obo:CHEBI_50267 a rdfs:Class ;
rdfs:label "protective agent" ;
rdfs:comment "Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent." ;
rdfs:subClassOf obo:CHEBI_23888 .
obo:CHEBI_24532 a rdfs:Class ;
rdfs:label "organic heterocyclic compound" ;
rdfs:comment "A cyclic compound having as ring members atoms of carbon and at least of one other element." ;
rdfs:subClassOf obo:CHEBI_33285 , obo:CHEBI_33832 , obo:CHEBI_5686 .
obo:PROCO_0000025 a rdfs:Class ;
rdfs:label "chemical product"@en ;
rdfs:comment "A chemical entity that is the end point product generated from a synthetic chemical process." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:PROCO_0000081 a rdfs:Class ;
rdfs:label "route development optimization"@en ;
rdfs:comment "A planned process that is about optimizing a synthetic route." ;
rdfs:subClassOf obo:PROCO_0000099 .
obo:OBI_0000070 a rdfs:Class ;
rdfs:label "assay"@en ;
rdfs:comment "A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies."@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:PROCO_0000229 a rdfs:Class ;
rdfs:label "partial rate order" ;
rdfs:comment "The exponent terms within the rate equation. For elementary (single step) reactions, the reactant order is equal to the stoichiometric coefficient of the reactant." ;
rdfs:subClassOf obo:PROCO_0000062 .
obo:CHMO_0001458 a rdfs:Class ;
rdfs:label "solvothermal synthesis" ;
rdfs:comment "A synthesis method for growing single crystals from a non-aqueous solution in an autoclave (a thick-walled steel vessel) at high temperature (400 °C) and pressure." ;
rdfs:subClassOf obo:CHMO_0001301 .
obo:CHEBI_78295 a rdfs:Class ;
rdfs:label "food component" ;
rdfs:comment "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." ;
rdfs:subClassOf obo:CHEBI_52211 .
obo:PROCO_0000003 a rdfs:Class ;
rdfs:label "prior art" ;
rdfs:comment "All information that has been made available to the public in any form before a given date that might be relevant to a patent's claims of originality." ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHMO_0002106 a rdfs:Class ;
rdfs:label "physical blending" ;
rdfs:comment "The process of making a polymer blend by mechanically mixing different polymers together in the melt." ;
rdfs:subClassOf obo:CHMO_0001685 .
obo:CHEBI_35406 a rdfs:Class ;
rdfs:label "oxoanion" ;
rdfs:comment "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." ;
rdfs:subClassOf obo:CHEBI_25741 , obo:CHEBI_33273 .
obo:PROCO_0000160 a rdfs:Class ;
rdfs:label "Powder Indexing"@en ;
rdfs:comment "An in-silico modeling to predict the unit cell of the crystal lattice based on the powder x-ray diffractogram" ;
rdfs:subClassOf obo:PROCO_0000159 .
obo:CHEBI_46787 a rdfs:Class ;
rdfs:label "solvent" ;
rdfs:comment "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." ;
rdfs:subClassOf obo:CHEBI_33232 , obo:CHEBI_51086 .
obo:CHEBI_38155 a rdfs:Class ;
rdfs:label "phytosiderophore" ;
rdfs:comment "Any of low-molecular-mass iron(III)-chelating compounds produced by plants for the purpose of the transport and sequestration of iron." ;
rdfs:subClassOf obo:CHEBI_24028 , obo:CHEBI_24874 .
obo:CHEBI_24432 a rdfs:Class ;
rdfs:label "biological role" ;
rdfs:comment "A role played by the molecular entity or part thereof within a biological context." ;
rdfs:subClassOf obo:BFO_0000023 .
obo:CHMO_0001987 a rdfs:Class ;
rdfs:label "supercritical carbon dioxide drying" ;
rdfs:comment "The removal of solvent from a sample without passing through the liquid–gas boundary, by immersion in supercritical CO2 and de-pressurisation." ;
rdfs:subClassOf obo:CHMO_0001556 .
a rdfs:Class ;
rdfs:label "transferring" ;
rdfs:comment "Transferring is channeling a flow (material, energy, signal) from one place to another. [NIST]" ;
rdfs:subClassOf .
obo:RO_0002337 a rdf:Property ;
rdfs:range .
obo:RO_0002344 a rdf:Property ;
rdfs:range .
obo:CHEBI_29067 a rdfs:Class ;
rdfs:label "carboxylic acid anion" ;
rdfs:comment "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." ;
rdfs:subClassOf obo:CHEBI_25696 , obo:CHEBI_35406 .
obo:PATO_0000033 a rdfs:Class ;
rdfs:label "concentration of" ;
rdfs:comment "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." ;
rdfs:subClassOf obo:PATO_0002182 .
obo:CHEBI_25698 a rdfs:Class ;
rdfs:label "ether" ;
rdfs:comment "An organooxygen compound with formula ROR, where R is not hydrogen." ;
rdfs:subClassOf obo:CHEBI_36963 .
obo:CHEBI_48355 a rdfs:Class ;
rdfs:label "non-polar solvent" ;
rdfs:subClassOf obo:CHEBI_46787 .
obo:IAO_0000577 a rdfs:Class ;
rdfs:label "centrally registered identifier symbol"@en ;
rdfs:comment "A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry."@en ;
rdfs:subClassOf obo:IAO_0000028 .
obo:CHEBI_36823 a rdfs:Class ;
rdfs:label "pseudohalo group" ;
rdfs:subClassOf obo:CHEBI_24433 .
obo:CHEBI_33674 a rdfs:Class ;
rdfs:label "s-block molecular entity" ;
rdfs:comment "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." ;
rdfs:subClassOf obo:CHEBI_33579 .
obo:CHEBI_79388 a rdfs:Class ;
rdfs:label "divalent inorganic anion" ;
rdfs:comment "Any inorganic anion with a valency of two." ;
rdfs:subClassOf obo:CHEBI_24834 .
obo:PROCO_0000223 a rdfs:Class ;
rdfs:label "DEREK Mutagen Prediction" ;
rdfs:comment "An is-silico modeling based on DEREK that determines the risk of a chemical being a mutagenic impurity" ;
rdfs:subClassOf obo:PROCO_0000159 .
a rdf:Property ;
rdfs:range .
obo:PROCO_0000233 a rdfs:Class ;
rdfs:label "integral kinetic measurement" ;
rdfs:comment "A kinetic determination method that measures the concentration of reaction species which is proportional to the integral of the reaction rate." ;
rdfs:subClassOf obo:PROCO_0000085 .
obo:OBI_0000796 a rdfs:Class ;
rdfs:label "purification objective" ;
rdfs:comment "The objective to separate a material entity into different compositions of which one or more have are purified fractions that contain higher concentration of a desired component, while others contain impurities and are not of interest." ;
rdfs:subClassOf obo:IAO_0000005 .
obo:OBI_0000833 a rdf:Property ;
rdfs:label "objective_achieved_by" ;
rdfs:comment "This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process." ;
rdfs:domain obo:IAO_0000005 ;
rdfs:range obo:OBI_0000011 .
obo:CHEBI_25696 a rdfs:Class ;
rdfs:label "organic anion" ;
rdfs:comment "Any organic ion with a net negative charge." ;
rdfs:subClassOf obo:CHEBI_22563 , obo:CHEBI_25699 .
obo:PROCO_0000295 a rdfs:Class ;
rdfs:label "process chemistry datum" ;
rdfs:comment "A data item about process chemistry" ;
rdfs:subClassOf obo:IAO_0000027 .
obo:BFO_0000027 a rdfs:Class ;
rdfs:label "object aggregate"@en ;
rdfs:subClassOf obo:BFO_0000040 .
a rdfs:Class ;
rdfs:label "molar concentration (quality)" ;
rdfs:comment "Molar concentration is the ratio of molar amount of a substance divided by volume of mixture containing the amount of substance. [Allotrope]" ;
rdfs:subClassOf obo:PATO_0000033 .
obo:IAO_0000100 a rdfs:Class ;
rdfs:label "data set"@en ;
rdfs:comment "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets."@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:CHEBI_15347 a rdfs:Class ;
rdfs:label "acetone" ;
rdfs:comment "A methyl ketone that consists of propane bearing an oxo group at C2." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_26292 , obo:CHEBI_51867 , obo:CHEBI_73693 .
obo:PROCO_0000132 a rdfs:Class ;
rdfs:label "unit cell volume"@en ;
rdfs:comment "The volume of the unit cell" ;
rdfs:subClassOf obo:PROCO_0000109 .
a rdfs:Class ;
rdfs:label "specified impurity role" ;
rdfs:comment "An impurity that is individually listed and limited with aspecific acceptance criterion in the new drug substance specification. A specified impurity can be either identified or unidentified. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:CHMO_0001595 a rdfs:Class ;
rdfs:label "polymeric membrane extraction" ;
rdfs:comment "The transfer of a solute from one phase (the 'donor' or 'feed' phase) to another (the 'acceptor' or 'strip' phase) across a nonporous sillicon rubber membrane." ;
rdfs:subClassOf obo:CHMO_0001593 .
obo:PROCO_0000238 a rdfs:Class ;
rdfs:label "mutagenic impurity" ;
rdfs:comment "An impurity role of DNA reactive material that have significant carcinogenic risk" ;
rdfs:subClassOf .
obo:CHEBI_50584 a rdfs:Class ;
rdfs:label "alkyl alcohol" ;
rdfs:comment "An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position." ;
rdfs:subClassOf obo:CHEBI_2571 .
obo:PROCO_0000033 a rdfs:Class ;
rdfs:label "GMP synthetic process"@en ;
rdfs:comment "A synthetic process governed by the cGMP regulations." ;
rdfs:subClassOf obo:PROCO_0000001 .
obo:PROCO_0000194 a rdfs:Class ;
rdfs:label "syringe pump"@en ;
rdfs:comment "A syringe which has the function of pumping material into an experiment." ;
rdfs:subClassOf .
obo:CHMO_0002066 a rdfs:Class ;
rdfs:label "trituration" ;
rdfs:comment "Purification of crude chemical compounds containing solid impurities where a solvent is chosen in which the desired product is insoluble and the undesired by-products are very soluble (or vice versa). The crude material is washed with the solvent and filtered away, leaving the purified product in solid form and any impurities in solution." ;
rdfs:subClassOf obo:CHMO_0002231 .
obo:PROCO_0000105 a rdfs:Class ;
rdfs:label "method of flooding" ;
rdfs:comment "A kinetic determination method to determine the partial order of a reactant by measuring the concentration of that reactant with all other reactants in large excess" ;
rdfs:subClassOf obo:PROCO_0000233 .
obo:CHEBI_48431 a rdfs:Class ;
rdfs:label "formimidic acid" ;
rdfs:comment "A carboximidic acid that is formic acid in which the carbonyl oxygen is replaced by an imino group." ;
rdfs:subClassOf obo:CHEBI_48378 , obo:CHEBI_64708 .
obo:PROCO_0000290 a rdfs:Class ;
rdfs:label "Control Strategy" ;
rdfs:comment "A planned set of controls, derived from current product and process understanding that ensures process performance and product quality. The controls can include parameters and attributes related to drug substance and drug product materials and components, facility and equipment operating conditions, in-process controls, finished product specifications, and the associated methods and frequency of monitoring and control." ;
rdfs:subClassOf obo:IAO_0000033 .
obo:PROCO_0000212 a rdfs:Class ;
rdfs:label "appearance datum"@en ;
rdfs:comment "A data item that is about a material entity based on a visual inspection." ;
rdfs:subClassOf obo:IAO_0000027 .
obo:PROCO_0000044 a rdfs:Class ;
rdfs:label "material flow profile in synthesis process"@en ;
rdfs:comment "A process profile in synthesis process that is about material flow" ;
rdfs:subClassOf obo:PROCO_0000047 .
obo:CHMO_0002218 a rdfs:Class ;
rdfs:label "fractional sublimation" ;
rdfs:comment "A method for purifying samples by heating the sample under reduced pressure and allowing the fractions to sublime order of increasing sublimation temperature (a function of vapor pressure)." ;
rdfs:subClassOf obo:CHMO_0002217 .
obo:CHEBI_48873 a rdfs:Class ;
rdfs:label "cholinergic antagonist" ;
rdfs:comment "Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists." ;
rdfs:subClassOf obo:CHEBI_38323 .
obo:IAO_0000572 a rdfs:Class ;
rdfs:label "documenting"@en ;
rdfs:comment "A planned process in which a document is created or added to by including the specified input in it."@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHEBI_49637 a rdfs:Class ;
rdfs:label "hydrogen atom" ;
rdfs:subClassOf obo:CHEBI_24835 , obo:CHEBI_25585 , obo:CHEBI_33559 .
obo:BFO_0000023 a rdfs:Class ;
rdfs:label "role"@en ;
rdfs:comment "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts."@en ;
rdfs:subClassOf obo:BFO_0000017 .
obo:FIX_0000285 a rdfs:Class ;
rdfs:label "redox potential change" ;
rdfs:subClassOf obo:FIX_0000281 , obo:FIX_0000369 .
obo:CHEBI_52214 a rdfs:Class ;
rdfs:label "ligand" ;
rdfs:comment "Any molecule or ion capable of binding to a central metal atom to form coordination complexes." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_64708 a rdfs:Class ;
rdfs:label "one-carbon compound" ;
rdfs:comment "An organic molecular entity containing a single carbon atom (C1)." ;
rdfs:subClassOf obo:CHEBI_50860 .
obo:PATO_0001536 a rdfs:Class ;
rdfs:label "solubility" ;
rdfs:comment "A molecular quality that inheres in a molecular entity by virtue of the bearer's disposition to dissolve in a liquid." ;
rdfs:subClassOf obo:PATO_0002182 .
obo:PROCO_0000013 a rdfs:Class ;
rdfs:label "critical quality attribute"@en ;
rdfs:comment "A physical, chemical, biological, or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality." ;
rdfs:subClassOf obo:BFO_0000019 .
obo:OBI_0302888 a rdfs:Class ;
rdfs:label "washing" ;
rdfs:comment "Washing is a process by which a material entity acting as contaminant (e.g. excess staining reagent) is removed by application of one or more cycles of solution in flow." ;
rdfs:subClassOf obo:CHMO_0002742 .
obo:CHEBI_22221 a rdfs:Class ;
rdfs:label "acyl group" ;
rdfs:comment "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." ;
rdfs:subClassOf obo:CHEBI_33247 .
obo:CHEBI_25212 a rdfs:Class ;
rdfs:label "metabolite" ;
rdfs:comment "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." ;
rdfs:subClassOf obo:CHEBI_52206 .
a rdfs:Class ;
rdfs:label "cleaning agent role" ;
rdfs:comment "Cleaning agent role is a role of material used for cleaning something. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000059 a rdfs:Class ;
rdfs:label "fate of impurity"@en ;
rdfs:comment "A process chemistry datum describing the ultimate final state and location of an impurity in a synthetic process." ;
rdfs:subClassOf obo:BFO_0000016 , obo:PROCO_0000295 .
obo:CHEBI_63047 a rdfs:Class ;
rdfs:label "food emulsifier" ;
rdfs:comment "A food additive used to form or maintain a uniform emulsion of two (or more) phases in a food." ;
rdfs:subClassOf obo:CHEBI_63046 , obo:CHEBI_64047 .
obo:BFO_0000016 a rdfs:Class ;
rdfs:label "disposition"@en ;
rdfs:subClassOf obo:BFO_0000017 .
obo:OBI_0002488 a rdfs:Class ;
rdfs:label "pipette" ;
rdfs:comment "A device that is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser." ;
rdfs:subClassOf obo:OBI_0000968 .
obo:PROCO_0000167 a rdfs:Class ;
rdfs:label "assessed ionisability purge factor" ;
rdfs:comment "An assessed purge factor based on the ionisability of the impurity relative to desired compound and therefore its propensity to be purged in the waste layer of a biphasic system in steps that involve such an extraction." ;
rdfs:subClassOf obo:PROCO_0000070 .
obo:GO_0042575 a rdfs:Class ;
rdfs:label "DNA polymerase complex" ;
rdfs:comment "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." ;
rdfs:subClassOf obo:GO_0032991 , obo:OBI_0000427 .
obo:PROCO_0000230 a rdfs:Class ;
rdfs:label "overall reaction order" ;
rdfs:comment "The sum of stoichiometric coefficients of reactants, is always equal to the molecularity of the elementary reaction. However, complex (multi-step) reactions may or may not have reaction orders equal to their stoichiometric coefficients." ;
rdfs:subClassOf obo:PROCO_0000062 .
obo:CHMO_0001640 a rdfs:Class ;
rdfs:label "filtration" ;
rdfs:comment "The process of segregation of phases; the separation of suspended solids from a liquid or gas, usually by forcing a carrier gas or liquid through a porous medium." ;
rdfs:subClassOf obo:CHMO_0002231 .
obo:PROCO_0000077 a rdfs:Class ;
rdfs:label "process excellence index"@en ;
rdfs:comment "The process excellence index (PEI) is a measure of process reproducibility where the robustness of the procedure is evaluated in terms of yield and cycle time of various operations." ;
rdfs:subClassOf obo:PROCO_0000295 .
obo:GO_0003674 a rdfs:Class ;
rdfs:label "molecular_function" ;
rdfs:comment "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:PROCO_0000126 a rdfs:Class ;
rdfs:label "trigonal unit cell"@en ;
rdfs:comment "A unit cell of three equal lateral axes intersecting at the same angle but not perpendicularly" ;
rdfs:subClassOf obo:PROCO_0000120 .
obo:CHEBI_33249 a rdfs:Class ;
rdfs:label "organyl group" ;
rdfs:comment "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." ;
rdfs:subClassOf obo:CHEBI_51447 .
obo:PROCO_0000156 a rdfs:Class ;
rdfs:label "hexoctahedral"@en ;
rdfs:comment """A cubic system crystal class with 48 equal triangular faces
and three identical crystallographic axes with four fold rotational axes and centrosymmetric point symmetry""" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:FIX_0000368 a rdfs:Class ;
rdfs:label "kinetic reaction property" ;
rdfs:subClassOf obo:FIX_0000277 .
obo:PROCO_0000052 a rdfs:Class ;
rdfs:label "crystallization"@en ;
rdfs:comment "A process that has as a material output a crystalline solid or a mixture that has as an ingredient a crystalline solid." ;
rdfs:subClassOf obo:PROCO_0000051 .
obo:RO_0002234 a rdf:Property ;
rdfs:range .
obo:OBI_0000427 a rdfs:Class ;
rdfs:label "enzyme"@en ;
rdfs:comment """(protein or rna) or has_part (protein or rna) and
has_function some GO:0003824 (catalytic activity)"""@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:OBI_0600014 a rdfs:Class ;
rdfs:label "material component separation" ;
rdfs:comment "A material processing in which components of an input material become segregated in space." ;
rdfs:subClassOf obo:OBI_0000094 .
obo:CHEBI_17824 a rdfs:Class ;
rdfs:label "propan-2-ol" ;
rdfs:comment "A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group." ;
rdfs:subClassOf obo:CHEBI_167095 , obo:CHEBI_35681 .
obo:CHMO_0002015 a rdfs:Class ;
rdfs:label "differential centrifugation" ;
rdfs:comment "A separation method where the components of a cell are separated on the basis of their density in a centrifuge according to the centrifugal force they experience. The sample is centrifuged in a number of separate, sequential steps; each time the pellet is removed and the speed increased." ;
rdfs:subClassOf obo:CHMO_0002011 .
obo:CHEBI_33253 a rdfs:Class ;
rdfs:label "nucleon" ;
rdfs:comment "Heavy nuclear particle: proton or neutron." ;
rdfs:subClassOf obo:CHEBI_36339 , obo:CHEBI_36347 .
obo:CHEBI_51446 a rdfs:Class ;
rdfs:label "organic divalent group" ;
rdfs:subClassOf obo:CHEBI_33247 .
obo:CHEBI_28868 a rdfs:Class ;
rdfs:label "fatty acid anion" ;
rdfs:comment "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." ;
rdfs:subClassOf obo:CHEBI_18059 , obo:CHEBI_35757 .
obo:CHEBI_76413 a rdfs:Class ;
rdfs:label "greenhouse gas" ;
rdfs:comment "A gas in an atmosphere that absorbs and emits radiation within the thermal infrared range, so contributing to the 'greenhouse effect'." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_77941 a rdfs:Class ;
rdfs:label "EC 3.5.1.4 (amidase) inhibitor" ;
rdfs:comment "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." ;
rdfs:subClassOf obo:CHEBI_76807 .
obo:CHEBI_13193 a rdfs:Class ;
rdfs:label "hydrogen acceptor" ;
rdfs:comment "A molecular entity that can undergo reduction by the gain of hydrogen atom(s)." ;
rdfs:subClassOf obo:CHEBI_17654 .
obo:OBI_0000471 a rdfs:Class ;
rdfs:label "study design execution" ;
rdfs:comment "a planned process that carries out a study design" ;
rdfs:subClassOf obo:OBI_0000011 .
obo:PROCO_0000244 a rdfs:Class ;
rdfs:label "diploidal" ;
rdfs:comment "Isometric form with no 4 fold axes and centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHMO_0001310 a rdfs:Class ;
rdfs:label "sample deposition" ;
rdfs:comment "The process of the settling of particles (atoms or molecules) from a solution, suspension or vapour onto a pre-existing surface, resulting in the growth of a new phase." ;
rdfs:subClassOf obo:CHMO_0001301 .
obo:CHEBI_23424 a rdfs:Class ;
rdfs:label "cyanides" ;
rdfs:comment "Salts and C-organyl derivatives of hydrogen cyanide, HC#N." ;
rdfs:subClassOf obo:CHEBI_35352 .
obo:CHEBI_48356 a rdfs:Class ;
rdfs:label "protic solvent" ;
rdfs:comment "A polar solvent that is capable of acting as a hydron (proton) donor." ;
rdfs:subClassOf obo:CHEBI_39141 , obo:CHEBI_48354 .
obo:CHEBI_36347 a rdfs:Class ;
rdfs:label "nuclear particle" ;
rdfs:comment "A nucleus or any of its constituents in any of their energy states." ;
rdfs:subClassOf obo:CHEBI_36342 .
obo:PATO_0000122 a rdfs:Class ;
rdfs:label "length" ;
rdfs:comment "A 1-D extent quality which is equal to the distance between two points." ;
rdfs:subClassOf obo:PATO_0000051 .
obo:CHEBI_5686 a rdfs:Class ;
rdfs:label "heterocyclic compound" ;
rdfs:comment "A cyclic compound having as ring members atoms of at least two different elements." ;
rdfs:subClassOf obo:CHEBI_33595 .
obo:PROCO_0000279 a rdfs:Class ;
rdfs:label "Box–Behnken design" ;
rdfs:comment "An experimental design to produce a response curve sufficient to fit quadratic models of the individual factors" ;
rdfs:subClassOf obo:PROCO_0000276 .
obo:CHEBI_15022 a rdfs:Class ;
rdfs:label "electron donor" ;
rdfs:comment "A molecular entity that can transfer an electron to another molecular entity." ;
rdfs:subClassOf obo:CHEBI_17891 .
obo:CHEBI_15740 a rdfs:Class ;
rdfs:label "formate" ;
rdfs:comment "A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects." ;
rdfs:subClassOf obo:CHEBI_35757 .
obo:PROCO_0000104 a rdfs:Class ;
rdfs:label "drug product approval milestone"@en ;
rdfs:comment "A process boundary that represents a milestone of obtaining regulatory approval to sell a new drug product." ;
rdfs:subClassOf obo:PROCO_0000103 .
obo:CHEBI_73693 a rdfs:Class ;
rdfs:label "ketone body" ;
rdfs:comment "A carbonyl compound produced as a water-soluble byproduct when fatty acids are broken down for energy in the liver. There are three endogenous ketone bodies: acetone, acetoacetic acid, and (R)-3-hydroxybutyric acid; others may be produced as a result of the metabolism of synthetic triglycerides." ;
rdfs:subClassOf obo:CHEBI_36586 , obo:CHEBI_61697 .
obo:OBI_0000272 a rdfs:Class ;
rdfs:label "protocol"@en ;
rdfs:comment "A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process."@en ;
rdfs:subClassOf obo:IAO_0000104 .
obo:PROCO_0000117 a rdfs:Class ;
rdfs:label "unit cell a-axis length"@en ;
rdfs:comment "the length of the a-axis of a unit cell"@en ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:CHEBI_28938 a rdfs:Class ;
rdfs:label "ammonium" ;
rdfs:comment "An onium cation obtained by protonation of ammonia." ;
rdfs:subClassOf obo:CHEBI_35106 , obo:CHEBI_50313 , obo:CHEBI_60242 .
obo:PROCO_0000074 a rdfs:Class ;
rdfs:label "crystalline solid"@en ;
rdfs:comment "A solid with at least one crystalline phase" ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:CHEBI_36915 a rdfs:Class ;
rdfs:label "inorganic cation" ;
rdfs:subClassOf obo:CHEBI_36914 , obo:CHEBI_36916 .
obo:PROCO_0000115 a rdfs:Class ;
rdfs:label "enantiomorphic point symmetry"@en ;
rdfs:comment "a non-centrosymmetric point symmetry that cannot be rotated to align with the original structure (chiral)."@en ;
rdfs:subClassOf obo:PROCO_0000114 .
obo:IAO_0000030 a rdfs:Class ;
rdfs:label "information content entity" ;
rdfs:comment "A generically dependent continuant that is about some thing."@en ;
rdfs:subClassOf obo:BFO_0000031 .
obo:CHEBI_63248 a rdfs:Class ;
rdfs:label "oxidising agent" ;
rdfs:comment "A substance that removes electrons from another reactant in a redox reaction." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:PROCO_0000218 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.2.3 Control of Materials" ;
rdfs:comment "Materials used in the manufacture of the drug substance (e.g., raw materials, starting materials, solvents, reagents, catalysts) should be listed, identifying where each material is used in the process. Information on the quality and control of these materials should be provided. Reference ICH guidances Q6A and Q6B." ;
rdfs:subClassOf obo:IAO_0000314 .
a rdfs:Class ;
rdfs:label "enantiomeric impurity role" ;
rdfs:comment "An enantiomeric impurity is the impurity role of a compound with the same molecular formula as the drug substance that differs in the spatial arrangement of atoms within the molecule and is a non-superimposable mirror image. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:PROCO_0000241 a rdfs:Class ;
rdfs:label "rhombic-disphenoidal" ;
rdfs:comment "Four-faced closed orthorhombic form with enantiomorphic point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_38323 a rdfs:Class ;
rdfs:label "cholinergic drug" ;
rdfs:comment "Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons." ;
rdfs:subClassOf obo:CHEBI_35942 .
obo:CHEBI_33242 a rdfs:Class ;
rdfs:label "inorganic hydride" ;
rdfs:subClassOf obo:CHEBI_24835 , obo:CHEBI_33692 .
obo:CHMO_0001656 a rdfs:Class ;
rdfs:label "high-energy ball milling" ;
rdfs:comment "The mechanical reduction of the particle size of a solid sample by grinding with one or more inert balls (ceramic, flint or stainless steel, 2–8 mm diameter) rotating at high speed (up to 650 rpm) around a horizontal axis. A high-speed agitator is used to increase the speed of the balls which are held in vacuum or in an inert gas (e.g. Ar)." ;
rdfs:subClassOf obo:CHMO_0001654 .
obo:CHMO_0001645 a rdfs:Class ;
rdfs:label "ultra-filtration" ;
rdfs:comment "A separation process whereby a solution containing a solute of molecular size significantly greater than that of the solvent molecule is removed from the solvent by the application of hydraulic pressure which forces only the solvent to flow through a suitable membrane, usually having a pore size in the range 0.001–0.1 \\μm." ;
rdfs:subClassOf obo:CHMO_0001640 .
a rdfs:Class ;
rdfs:label "plasma" ;
rdfs:comment "A physical quality that inheres in a bearer by virtue of its plasma is a state of matter, that is, it does not have definite shape or volume. Unlike gases, plasmas are electrically conductive, produce magnetic fields and electric currents, and respond strongly to electromagnetic forces. Positively charged nuclei swim in a \"sea\" of freely-moving disassociated electrons, similar to the way such charges exist in conductive metal. [Wikipedia]" ;
rdfs:subClassOf .
obo:CHEBI_33245 a rdfs:Class ;
rdfs:label "organic fundamental parent" ;
rdfs:comment "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." ;
rdfs:subClassOf obo:CHEBI_37175 , obo:CHEBI_50860 .
obo:PROCO_0000055 a rdfs:Class ;
rdfs:label "impurity fate and purge determination"@en ;
rdfs:comment "A process that determines the fate of impurities (organic, inorganic, elemental, or residual solvents) of pharmaceutical substances produced by chemical syntheses to ensure the desired product quality, and the ability of the synthetic route to purge them." ;
rdfs:subClassOf obo:PROCO_0000086 .
obo:PROCO_0000116 a rdfs:Class ;
rdfs:label "non-centrosymmetric achiral symmetry"@en ;
rdfs:comment "a non-centrosymmetric point symmetry that can be rotated to align with the original structure (achiral)."@en ;
rdfs:subClassOf obo:PROCO_0000114 .
obo:BFO_0000001 a rdfs:Class ;
rdfs:label "entity"@en .
obo:GO_0003824 a rdfs:Class ;
rdfs:label "catalytic activity" ;
rdfs:comment "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." ;
rdfs:subClassOf obo:GO_0003674 .
obo:CHEBI_52210 a rdfs:Class ;
rdfs:label "pharmacological role" ;
rdfs:comment "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:CHEBI_18059 a rdfs:Class ;
rdfs:label "lipid" ;
rdfs:comment "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." ;
rdfs:subClassOf obo:CHEBI_50860 .
a rdfs:Class ;
rdfs:label "to store" ;
rdfs:comment "To accumulate a flow. [NIST]" ;
rdfs:subClassOf .
obo:PROCO_0000240 a rdfs:Class ;
rdfs:label "prismatic" ;
rdfs:comment "3, 4, 6, 8, or 12 faced monoclinic crystal with centrosymmetric point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_77962 a rdfs:Class ;
rdfs:label "food antioxidant" ;
rdfs:comment "An antioxidant that used as a food additives to help guard against food deterioration." ;
rdfs:subClassOf obo:CHEBI_22586 , obo:CHEBI_65255 .
obo:CHMO_0001989 a rdfs:Class ;
rdfs:label "ethanol extraction" ;
rdfs:comment "The process of transferring a substance from any matrix into ethanol." ;
rdfs:subClassOf obo:CHMO_0001598 .
obo:CHEBI_78433 a rdfs:Class ;
rdfs:label "refrigerant" ;
rdfs:comment "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." ;
rdfs:subClassOf obo:CHEBI_33232 .
obo:CHMO_0002012 a rdfs:Class ;
rdfs:label "low-speed centrifugation" ;
rdfs:comment "A separation method where the components of a sample are separated on the basis of their density in a centrifuge according to the centrifugal force they experience. Samples are spun at <5000 rpm." ;
rdfs:subClassOf obo:OBI_0302886 .
obo:CHEBI_17514 a rdfs:Class ;
rdfs:label "cyanide" ;
rdfs:comment "A pseudohalide anion that is the conjugate base of hydrogen cyanide." ;
rdfs:subClassOf obo:CHEBI_36828 .
obo:CHEBI_26292 a rdfs:Class ;
rdfs:label "propanones" ;
rdfs:comment "A ketone that is propane carrying at least one oxo substituent." ;
rdfs:subClassOf obo:CHEBI_17087 .
obo:OBI_0000338 a rdfs:Class ;
rdfs:label "drawing a conclusion based on data"@en ;
rdfs:comment "A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion"@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHMO_0001540 a rdfs:Class ;
rdfs:label "vacuum distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a high-boiling-point sample mixture are vaporised by the application of heat at low pressure and then cooled by the action of cold water in a condenser." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:CHEBI_36358 a rdfs:Class ;
rdfs:label "polyatomic ion" ;
rdfs:comment "An ion consisting of more than one atom." ;
rdfs:subClassOf obo:CHEBI_24870 , obo:CHEBI_36357 .
obo:PROCO_0000273 a rdfs:Class ;
rdfs:label "ICH Q6A Class 3 Solvent" ;
rdfs:comment "Class 3 solvents: Solvents with low toxic potential Solvents with low toxic potential to man; no health-based exposure limit is needed. Class 3 solvents have PDEs of 50 mg or more per day." ;
rdfs:subClassOf obo:PROCO_0000270 .
obo:CHMO_0001578 a rdfs:Class ;
rdfs:label "coextraction" ;
rdfs:comment "The transfer of two solutes from a liquid phase to a (low-polarity) organic liquid phase in contact with it. The solutes form mixed-species aggregates in the organic phase." ;
rdfs:subClassOf obo:CHMO_0001577 .
obo:CHEBI_33285 a rdfs:Class ;
rdfs:label "heteroorganic entity" ;
rdfs:comment "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." ;
rdfs:subClassOf obo:CHEBI_50860 .
obo:CHMO_0001606 a rdfs:Class ;
rdfs:label "shake-flask extraction" ;
rdfs:comment "The process of transferring a substance from any matrix to an appropriate liquid phase, during which the sample and solvent are kept in contact in a mechanical shaker." ;
rdfs:subClassOf obo:CHMO_0001598 .
obo:CHEBI_76736 a rdfs:Class ;
rdfs:label "EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor" ;
rdfs:comment "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on a heme group of donors (EC 1.9.*.*)." ;
rdfs:subClassOf obo:CHEBI_76725 .
obo:CHEBI_33256 a rdfs:Class ;
rdfs:label "primary amide" ;
rdfs:comment "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." ;
rdfs:subClassOf obo:CHEBI_32988 .
obo:PROCO_0000254 a rdfs:Class ;
rdfs:label "rhombohedral" ;
rdfs:comment "6 faced closed rhombohedral form of six identical faces in which none of the intersection edges is perpendicular and having centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000147 a rdfs:Class ;
rdfs:label "anhydrous phase"@en ;
rdfs:comment "A crystalline phase without solvent in the unit cell" ;
rdfs:subClassOf obo:PROCO_0000139 .
a rdfs:Class ;
rdfs:label "unidentified impurity role" ;
rdfs:comment "An impurity for which a structural characterization has not been achieved and that is defined solely by qualitative analytical properties (e.g., chromatographic retention time). [ICH-Q3A]" ;
rdfs:subClassOf .
obo:CHEBI_27780 a rdfs:Class ;
rdfs:label "detergent" ;
rdfs:comment "A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions." ;
rdfs:subClassOf obo:CHEBI_33232 , obo:CHEBI_35195 .
obo:PROCO_0000265 a rdfs:Class ;
rdfs:label "ICH Q3A Impurities in New Drug Substances" ;
rdfs:comment "An ICH guideline about identifying, qualifying and specifying impurities in drug substance." ;
rdfs:subClassOf obo:PROCO_0000136 .
obo:BFO_0000015 a rdfs:Class ;
rdfs:label "process" ;
rdfs:comment "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
rdfs:subClassOf obo:BFO_0000003 .
a rdfs:Class ;
rdfs:label "impurity role" ;
rdfs:comment "A material role for any component of material that is not part of the defined product at the particular stage of manufacture or storage. [Allotrope]" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "hygroscopicity" ;
rdfs:comment "Hygroscopicity is a quality inhered in a compound by virtue of its ability to readily take up and retain water, especially from the atmosphere. [Wikipedia]" ;
rdfs:subClassOf .
obo:CHEBI_48357 a rdfs:Class ;
rdfs:label "aprotic solvent" ;
rdfs:subClassOf obo:CHEBI_46787 .
obo:CHEBI_76725 a rdfs:Class ;
rdfs:label "EC 1.* (oxidoreductase) inhibitor" ;
rdfs:comment "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." ;
rdfs:subClassOf obo:CHEBI_23924 .
obo:PROCO_0000030 a rdfs:Class ;
rdfs:label "intermediate material for synthesis"@en ;
rdfs:comment "A chemical entity that is the product of a chemical reaction but not the last step in a synthesis." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:RO_0002353 a rdf:Property ;
rdfs:range .
obo:PROCO_0000178 a rdfs:Class ;
rdfs:label "condensor"@en ;
rdfs:comment "A device used to condense vapors into liquid by cooling." ;
rdfs:subClassOf .
obo:CHEBI_50908 a rdfs:Class ;
rdfs:label "hepatotoxic agent" ;
rdfs:comment "A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals." ;
rdfs:subClassOf obo:CHEBI_52209 .
obo:CHEBI_76971 a rdfs:Class ;
rdfs:label "Escherichia coli metabolite" ;
rdfs:comment "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." ;
rdfs:subClassOf obo:CHEBI_76969 .
obo:PROCO_0000111 a rdfs:Class ;
rdfs:label "point symmetry"@en ;
rdfs:comment "a geometric symmetry that keeps at least one point fixed"@en ;
rdfs:subClassOf obo:PATO_0000965 .
obo:IAO_0000007 a rdfs:Class ;
rdfs:label "action specification"@en ;
rdfs:comment "A directive information entity that describes an action the bearer will take."@en ;
rdfs:subClassOf obo:IAO_0000033 .
obo:PROCO_0000129 a rdfs:Class ;
rdfs:label "unit cell alpha internal angle"@en ;
rdfs:comment "A unit cell quality describing the angle between the b and c axes." ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:PATO_0000051 a rdfs:Class ;
rdfs:label "morphology" ;
rdfs:comment "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." ;
rdfs:subClassOf obo:BFO_0000019 , obo:PATO_0000001 .
obo:CHEBI_75768 a rdfs:Class ;
rdfs:label "mammalian metabolite" ;
rdfs:comment "Any animal metabolite produced during a metabolic reaction in mammals." ;
rdfs:subClassOf obo:CHEBI_75767 .
obo:PROCO_0000284 a rdfs:Class ;
rdfs:label "bill of materials" ;
rdfs:comment "A document that lists the raw materials, sub-assemblies, intermediate assemblies, sub-components, parts, and the quantities of each needed to manufacture an end product." ;
rdfs:subClassOf obo:IAO_0000310 .
obo:FIX_0000277 a rdfs:Class ;
rdfs:label "reaction property" ;
rdfs:subClassOf obo:BFO_0000144 .
obo:CHEBI_38472 a rdfs:Class ;
rdfs:label "acetonitrile" ;
rdfs:comment "A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_80291 .
obo:CHEBI_22586 a rdfs:Class ;
rdfs:label "antioxidant" ;
rdfs:comment "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_38975 a rdfs:Class ;
rdfs:label "methylbenzene" ;
rdfs:comment "Any alkylbenzene that is benzene substituted with one or more methyl groups." ;
rdfs:subClassOf obo:CHEBI_38976 .
obo:CHEBI_36914 a rdfs:Class ;
rdfs:label "inorganic ion" ;
rdfs:subClassOf obo:CHEBI_24835 , obo:CHEBI_24870 .
obo:PROCO_0000085 a rdfs:Class ;
rdfs:label "mechanistic and kinetic determination"@en ;
rdfs:comment "Chemical kinetics includes investigations of how experimental conditions influence the speed of a chemical reaction and yield information about the reaction's mechanism and transition states, as well as the construction of mathematical models that also can describe the characteristics of a chemical reaction." ;
rdfs:subClassOf obo:PROCO_0000093 .
obo:BFO_0000004 a rdfs:Class ;
rdfs:label "independent continuant"@en ;
rdfs:comment "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
rdfs:subClassOf obo:BFO_0000002 .
obo:CHEBI_39144 a rdfs:Class ;
rdfs:label "Lewis base" ;
rdfs:comment "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." ;
rdfs:subClassOf obo:CHEBI_17891 , obo:CHEBI_22695 .
obo:OBI_0001909 a rdfs:Class ;
rdfs:label "conclusion based on data" ;
rdfs:comment "An information content entity that is inferred from data." ;
rdfs:subClassOf obo:IAO_0000030 .
obo:OBI_0000124 a rdf:Property ;
rdfs:label "is_supported_by_data" ;
rdfs:comment "The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process" ;
rdfs:domain obo:OBI_0001909 ;
rdfs:range obo:IAO_0000027 .
obo:PROCO_0000094 a rdfs:Class ;
rdfs:label "review of prior art"@en ;
rdfs:comment "An investigation of published material to find prior art related to a synthetic route" ;
rdfs:subClassOf obo:OBI_0000066 .
obo:CHEBI_17087 a rdfs:Class ;
rdfs:label "ketone" ;
rdfs:comment "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." ;
rdfs:subClassOf obo:CHEBI_36586 .
obo:CHEBI_24651 a rdfs:Class ;
rdfs:label "hydroxides" ;
rdfs:comment "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." ;
rdfs:subClassOf obo:CHEBI_25806 , obo:CHEBI_33608 , obo:CHEBI_37577 .
obo:CHEBI_25747 a rdfs:Class ;
rdfs:label "oxidized luciferins" ;
rdfs:subClassOf obo:CHEBI_25078 .
a rdfs:Class ;
rdfs:label "drying medium role" ;
rdfs:comment "A drying medium role is a drying role of a material that takes or transports the solvent from the material being dried. [Allotrope]" ;
rdfs:subClassOf .
obo:CHEBI_48377 a rdfs:Class ;
rdfs:label "imidic acid" ;
rdfs:comment "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH)." ;
rdfs:subClassOf obo:CHEBI_33241 , obo:CHEBI_51143 .
obo:CHEBI_138675 a rdfs:Class ;
rdfs:label "gas molecular entity" ;
rdfs:comment "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." ;
rdfs:subClassOf obo:CHEBI_33579 .
obo:CHEBI_33281 a rdfs:Class ;
rdfs:label "antimicrobial agent" ;
rdfs:comment "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:CHMO_0000997 a rdfs:Class ;
rdfs:label "chromatography column" ;
rdfs:comment "A piece of apparatus that has the form of a tube with a diameter between 5 to 50 mm and hosts the stationary bed in chromatography." ;
rdfs:subClassOf obo:OBI_0000968 .
a rdfs:Class ;
rdfs:label "diffusion coefficient" ;
rdfs:comment "A proportionality constant between the molar flux due to molecular diffusion and the gradient in the concentration of the species (or the driving force for diffusion). Diffusivity is encountered in Fick's law and numerous other equations of physical chemistry." ;
rdfs:subClassOf .
obo:PROCO_0000301 a rdfs:Class ;
rdfs:label "multi-parallel experimentation" ;
rdfs:comment "A form of experimentation in which many related experiments (different conditions on the same compound or the same conditions on multiple compounds) are done simultaneously, typically in a well-plate platform." ;
rdfs:subClassOf obo:OBI_0000066 .
obo:CHEBI_25367 a rdfs:Class ;
rdfs:label "molecule" ;
rdfs:comment "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." ;
rdfs:subClassOf obo:CHEBI_36357 .
obo:CHEBI_33252 a rdfs:Class ;
rdfs:label "atomic nucleus" ;
rdfs:comment "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." ;
rdfs:subClassOf obo:CHEBI_36347 .
a rdfs:Class ;
rdfs:label "half-life" ;
rdfs:comment "Time interval over which a quantified entity is reduced to half its original value." ;
rdfs:subClassOf , .
obo:PROCO_0000161 a rdfs:Class ;
rdfs:label "crystal structure predictions"@en ;
rdfs:comment "An in-silico modeling to calculate calculation of the crystal structures by simulated annealing, evolutionary algorithms, distributed multipole analysis, random sampling, basin-hopping, data mining, density functional theory and molecular mechanics." ;
rdfs:subClassOf obo:PROCO_0000159 .
obo:PROCO_0000142 a rdfs:Class ;
rdfs:label "molecular complex"@en ;
rdfs:comment "An object aggregate of two or more molecular entities that does not include covalent or ionic interactions" ;
rdfs:subClassOf obo:BFO_0000027 .
obo:CHEBI_33292 a rdfs:Class ;
rdfs:label "fuel" ;
rdfs:comment "An energy-rich substance that can be transformed with release of usable energy." ;
rdfs:subClassOf obo:CHEBI_33232 .
a rdfs:Class ;
rdfs:label "chemical substance" ;
rdfs:comment "A chemical substance is a portion of material that is matter of constant composition best characterized by the entities (molecules, formula units, atoms) it is composed of. [IUPAC]" ;
rdfs:subClassOf obo:CHMO_0000993 .
obo:PROCO_0000106 a rdfs:Class ;
rdfs:label "induction period" ;
rdfs:comment "A temporal region of initial kinetics of a chemical reaction after which the reaction accelerates." ;
rdfs:subClassOf obo:BFO_0000008 .
obo:CHMO_0002124 a rdfs:Class ;
rdfs:label "blow drying" ;
rdfs:comment "The removal of solvent from a sample by the application of an inert gas or air." ;
rdfs:subClassOf obo:CHMO_0001549 .
a rdfs:Class ;
rdfs:label "to heat" ;
rdfs:comment "A function that gives thermal energy to a recipient. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000066 a rdfs:Class ;
rdfs:label "seed role"@en ;
rdfs:comment "The role of a crystalline solid material input in a crystallization to promote nucleation or crystal growth." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:OBI_0200166 a rdfs:Class ;
rdfs:label "data transformation objective"@en ;
rdfs:comment "An objective specification to transformation input data into output data"@en ;
rdfs:subClassOf obo:IAO_0000005 .
obo:CHEBI_33241 a rdfs:Class ;
rdfs:label "oxoacid derivative" ;
rdfs:subClassOf obo:CHEBI_37577 .
obo:CHMO_0002225 a rdfs:Class ;
rdfs:label "Acheson method" ;
rdfs:comment "A method for growing low-purity polycrystalline SiC. A mixture of silica, carbon, sawdust and NaCl is heated to 2700 °C in a furnace, and the temperature gradually decreased." ;
rdfs:subClassOf obo:CHMO_0002224 .
obo:PROCO_0000082 a rdfs:Class ;
rdfs:label "route validation"@en ;
rdfs:comment "A planned process producing data to demonstrate that a commercial route meets regulatory requirements." ;
rdfs:subClassOf obo:PROCO_0000086 , obo:PROCO_0000099 .
obo:PROCO_0000171 a rdfs:Class ;
rdfs:label "beaker"@en ;
rdfs:comment "A beaker is a simple container for stirring, mixing and heating liquids commonly used in many laboratories. Beakers are generally cylindrical in shape, with a flat bottom. Most also have a small spout (or \"beak\") to aid pouring." ;
rdfs:subClassOf .
obo:CHEBI_61697 a rdfs:Class ;
rdfs:label "fatty acid derivative" ;
rdfs:comment "Any organic molecular entity derived from a fatty acid." ;
rdfs:subClassOf obo:CHEBI_50860 .
obo:CHEBI_23367 a rdfs:Class ;
rdfs:label "molecular entity" ;
rdfs:comment "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." ;
rdfs:subClassOf obo:BFO_0000040 , obo:CHEBI_24431 .
obo:CHEBI_46923 a rdfs:Class ;
rdfs:label "dioxane" ;
rdfs:comment "Any member of the class of dioxanes that is a cyclohexane in which two carbon atoms are replaced by oxygen atoms." ;
rdfs:subClassOf obo:CHEBI_36389 , obo:CHEBI_46926 .
obo:CHEBI_33893 a rdfs:Class ;
rdfs:label "reagent" ;
rdfs:comment "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." ;
rdfs:subClassOf obo:CHEBI_33232 .
obo:PROCO_0000237 a rdfs:Class ;
rdfs:label "Variable Time Normalisation Analysis" ;
rdfs:comment "A mechanistic and kinetic determination that compares concentration vs. time profiles in a series of experiments to identify product inhibition, catalyst deactivation and the order of components including catalysts." ;
rdfs:subClassOf obo:PROCO_0000085 .
a rdfs:Class ;
rdfs:label "to provision" ;
rdfs:comment "To accumulate or provide a material or energy flow. [NIST]" ;
rdfs:subClassOf obo:BFO_0000034 .
obo:CHEBI_33302 a rdfs:Class ;
rdfs:label "pnictogen molecular entity" ;
rdfs:comment "A p-block molecular entity containing any pnictogen." ;
rdfs:subClassOf obo:CHEBI_33675 .
obo:CHEBI_25585 a rdfs:Class ;
rdfs:label "nonmetal atom" ;
rdfs:subClassOf obo:CHEBI_33250 .
obo:CHEBI_36830 a rdfs:Class ;
rdfs:label "monoanion" ;
rdfs:subClassOf obo:CHEBI_22563 .
obo:PROCO_0000103 a rdfs:Class ;
rdfs:label "product approval milestone"@en ;
rdfs:comment "A process boundary that represents a milestone of obtaining regulatory approval to sell a new product." ;
rdfs:subClassOf obo:BFO_0000035 .
obo:CHEBI_26671 a rdfs:Class ;
rdfs:label "sideramine" ;
rdfs:subClassOf obo:CHEBI_26672 .
obo:PROCO_0000189 a rdfs:Class ;
rdfs:label "heating mantle"@en ;
rdfs:comment "An environmental control device used to apply heat directly to containers." ;
rdfs:subClassOf obo:PROCO_0000188 .
obo:CHMO_0001477 a rdfs:Class ;
rdfs:label "crystallisation" ;
rdfs:comment "The formation of a crystalline solid from a solution, melt vapour, or a different solid phase, generally by lowering the temperature or by evaporation of a solvent." ;
rdfs:subClassOf obo:CHMO_0002916 .
obo:CHEBI_35195 a rdfs:Class ;
rdfs:label "surfactant" ;
rdfs:comment "A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces." ;
rdfs:subClassOf obo:CHEBI_63046 .
obo:CHEBI_18044 a rdfs:Class ;
rdfs:label "dialkyl ketone" ;
rdfs:subClassOf obo:CHEBI_17087 .
obo:CHEBI_10545 a rdfs:Class ;
rdfs:label "electron" ;
rdfs:comment "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." ;
rdfs:subClassOf obo:CHEBI_36338 .
obo:CHMO_0001538 a rdfs:Class ;
rdfs:label "simple distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a sample mixture are vaporised by the application of heat and then immediately cooled by the action of cold water in a condenser. This method can only be used to separate mixtures where the components differ widely in boiling point (by approx. 25°)." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:CHEBI_25806 a rdfs:Class ;
rdfs:label "oxygen molecular entity" ;
rdfs:subClassOf obo:CHEBI_33304 .
obo:CHEBI_33655 a rdfs:Class ;
rdfs:label "aromatic compound" ;
rdfs:comment "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." ;
rdfs:subClassOf obo:CHEBI_33595 .
obo:PROCO_0000136 a rdfs:Class ;
rdfs:label "ICH Guideline"@en ;
rdfs:comment "A directive information entity issued by the International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use with the objective of achieving greater harmonisation worldwide to ensure that safe, effective and high quality medicines are developed, and registered and maintained across the world in the most resource efficient manner whilst meeting high standards. [ICH]" ;
rdfs:subClassOf obo:IAO_0000033 .
a rdfs:Class ;
rdfs:label "homogeneous mixture" ;
rdfs:comment "A homogeneous mixture is a portion of mixed material that has the same proportions of its components throughout a given sample. Homogeneous mixture can have a variable composition. [Wikipedia]" ;
rdfs:subClassOf .
obo:PROCO_0000291 a rdfs:Class ;
rdfs:label "risk assessment" ;
rdfs:comment "A document identifying and analyzing potential (future) events that may negatively impact individuals, assets, and/or the environment (i.e. hazard analysis); and making judgments \"on the tolerability of the risk on the basis of a risk analysis\" while considering influencing factors (i.e. risk evaluation)." ;
rdfs:subClassOf obo:IAO_0000310 .
obo:CHEBI_76870 a rdfs:Class ;
rdfs:label "EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor" ;
rdfs:comment "An EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.9.3.*)." ;
rdfs:subClassOf obo:CHEBI_76736 .
obo:CHEBI_33598 a rdfs:Class ;
rdfs:label "carbocyclic compound" ;
rdfs:comment "A homocyclic compound in which all of the ring members are carbon atoms." ;
rdfs:subClassOf obo:CHEBI_33597 , obo:CHEBI_33832 .
obo:PROCO_0000259 a rdfs:Class ;
rdfs:label "trigonal-dipyramidal" ;
rdfs:comment "6-faced hexagonal form with faces related by a 3-fold axis with a perpendicular mirror plane having non-centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000150 a rdfs:Class ;
rdfs:label "concomitant polymorphs"@en ;
rdfs:comment "A heterogeneous solid solution consisting of two or more polymorphs of the same chemical entity" ;
rdfs:subClassOf obo:PROCO_0000074 , .
obo:PROCO_0000201 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.1.1 Nomenclature"@en ;
rdfs:comment "The drug substance nomenclature section of the CTA" ;
rdfs:subClassOf obo:IAO_0000314 .
obo:CHEBI_24431 a rdfs:Class ;
rdfs:label "chemical entity" ;
rdfs:comment "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:IAO_0000104 a rdfs:Class ;
rdfs:label "plan specification"@en ;
rdfs:comment "A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified."@en ;
rdfs:subClassOf obo:IAO_0000033 .
obo:CHEBI_64297 a rdfs:Class ;
rdfs:label "reaction intermediate" ;
rdfs:comment "Any chemical substance produced during the conversion of a reactant to a product." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_51268 a rdfs:Class ;
rdfs:label "drying control chemical additive" ;
rdfs:comment "A role played by a compound that facilitates the rapid drying of gels without their cracking." ;
rdfs:subClassOf obo:CHEBI_46787 .
obo:CHEBI_39141 a rdfs:Class ;
rdfs:label "Bronsted acid" ;
rdfs:comment "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." ;
rdfs:subClassOf obo:CHEBI_17891 , obo:CHEBI_37527 .
obo:CHEBI_27024 a rdfs:Class ;
rdfs:label "toluenes" ;
rdfs:comment "Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group." ;
rdfs:subClassOf obo:CHEBI_22712 .
obo:CHEBI_76946 a rdfs:Class ;
rdfs:label "fungal metabolite" ;
rdfs:comment "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." ;
rdfs:subClassOf obo:CHEBI_75763 .
obo:CHEBI_138103 a rdfs:Class ;
rdfs:label "inorganic acid" ;
rdfs:comment "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." ;
rdfs:subClassOf obo:CHEBI_39141 .
obo:PROCO_0000071 a rdfs:Class ;
rdfs:label "crystallization yield"@en ;
rdfs:comment "A process chemistry datum quantifying the ratio of the mass of desired compound recovered as crystalline material from a crystallization to mass of compound input into the crystallization." ;
rdfs:subClassOf obo:PROCO_0000295 .
obo:CHEBI_16397 a rdfs:Class ;
rdfs:label "formamide" ;
rdfs:comment "The simplest monocarboxylic acid amide, obtained by formal condensation of formic acid with ammonia. The parent of the class of formaldehydes." ;
rdfs:subClassOf obo:CHEBI_24079 , obo:CHEBI_29347 , obo:CHEBI_64708 .
obo:PROCO_0000041 a rdfs:Class ;
rdfs:label "GLP synthetic process"@en ;
rdfs:comment "A synthetic process governed by the GLP regulations." ;
rdfs:subClassOf obo:PROCO_0000001 .
obo:PROCO_0000190 a rdfs:Class ;
rdfs:label "round bottom flask"@en ;
rdfs:comment "A round-bottom flask is a flask with a spherical body and one or more necks with ground glass joints." ;
rdfs:subClassOf obo:PROCO_0000191 .
obo:PROCO_0000182 a rdfs:Class ;
rdfs:label "Davies condenser"@en ;
rdfs:comment "A condensor with three concentric glass tubes where coolant circulates in both the outer jacket and the central tube to increase the cooling surface," ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:CHMO_0001551 a rdfs:Class ;
rdfs:label "direct drying" ;
rdfs:comment "The removal of solvent from a sample by the application of heated air." ;
rdfs:subClassOf obo:CHMO_0002124 .
a rdfs:Class ;
rdfs:label "product role" ;
rdfs:comment "A role of a material that is intended and desired to be produced in a synthesis. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000049 a rdfs:Class ;
rdfs:label "reaction rate profile"@en ;
rdfs:comment "Reaction rate is the rate of the changing concentration of a product during a reaction process." ;
rdfs:subClassOf obo:PROCO_0000011 .
obo:CHMO_0001556 a rdfs:Class ;
rdfs:label "supercritical drying" ;
rdfs:comment "The removal of solvent from a sample without passing through the liquid–gas boundary, by immersion in a supercritical fluid and de-pressurisation." ;
rdfs:subClassOf obo:CHMO_0001549 .
obo:PROCO_0000131 a rdfs:Class ;
rdfs:label "unit cell gamma internal angle"@en ;
rdfs:comment "A unit cell quality describing the angle between the a and b axes." ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:CHEBI_17741 a rdfs:Class ;
rdfs:label "N,N-dimethylformamide" ;
rdfs:comment "A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_24079 .
a rdfs:Class ;
rdfs:label "to control" ;
rdfs:comment "To alter or govern the size or amplitude of a flow (material, energy, signal). [NIST]" ;
rdfs:subClassOf obo:BFO_0000034 .
obo:CHEBI_36344 a rdfs:Class ;
rdfs:label "hadron" ;
rdfs:comment "Hadron is a subatomic particle which experiences the strong force." ;
rdfs:subClassOf obo:CHEBI_36343 .
obo:PROCO_0000032 a rdfs:Class ;
rdfs:label "GMP starting material"@en ;
rdfs:comment "A raw material, intermediate, or an AP chemical entity that is used in the production of an API and that is incorporated as a significant structural fragment into the structure of the API." ;
rdfs:subClassOf obo:PROCO_0000029 .
obo:PROCO_0000260 a rdfs:Class ;
rdfs:label "hexagonal-dipyrimidal" ;
rdfs:comment "12-faced hexagonal form with faces related by a 6-fold axis with a perpendicular mirror with a centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000159 a rdfs:Class ;
rdfs:label "in-silico modeling"@en ;
rdfs:comment "An experiment performed on computer or via computer simulation" ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHEBI_33664 a rdfs:Class ;
rdfs:label "monocyclic hydrocarbon" ;
rdfs:subClassOf obo:CHEBI_33663 .
obo:IAO_0000033 a rdfs:Class ;
rdfs:label "directive information entity" ;
rdfs:comment "An information content entity whose concretizations indicate to their bearer how to realize them in a process."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHEBI_24632 a rdfs:Class ;
rdfs:label "hydrocarbon" ;
rdfs:comment "A compound consisting of carbon and hydrogen only." ;
rdfs:subClassOf obo:CHEBI_33245 .
obo:CHEBI_53431 a rdfs:Class ;
rdfs:label "chain carrier" ;
rdfs:comment "The role played by a molecular entity, such as an atom or free radical, which is involved in chain-propagating reactions." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_48354 a rdfs:Class ;
rdfs:label "polar solvent" ;
rdfs:comment "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." ;
rdfs:subClassOf obo:CHEBI_46787 .
obo:CHMO_0001624 a rdfs:Class ;
rdfs:label "fermentation" ;
rdfs:comment "The process in which cells (microorganisms, plant or animal cells) are cultured in a bioreactor in a liquid or solid medium to convert organic substances into biomass (growth) or into products." ;
rdfs:subClassOf obo:OBI_0000011 , obo:OBI_0000094 .
obo:PROCO_0000083 a rdfs:Class ;
rdfs:label "reaction screening design"@en ;
rdfs:comment "A screening design to evaluate possible chemical reactions" ;
rdfs:subClassOf obo:PROCO_0000091 .
obo:OBI_0000011 a rdfs:Class ;
rdfs:label "planned process" ;
rdfs:comment "A process that realizes a plan which is the concretization of a plan specification."@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:OBI_0001931 a rdfs:Class ;
rdfs:label "scalar value specification" ;
rdfs:comment "A value specification that consists of two parts: a numeral and a unit label" ;
rdfs:subClassOf obo:OBI_0001933 .
obo:PROCO_0000072 a rdfs:Class ;
rdfs:label "mother liquor role"@en ;
rdfs:comment "A debris role of the solution in a slurry resulting from a crystallization" ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHMO_0002014 a rdfs:Class ;
rdfs:label "preparative centrifugation" ;
rdfs:comment "A method where a sample is purified by removing impurities on the basis of their density in a centrifuge." ;
rdfs:subClassOf obo:OBI_0302886 .
obo:CHEBI_63726 a rdfs:Class ;
rdfs:label "neuroprotective agent" ;
rdfs:comment "Any compound that can be used for the treatment of neurodegenerative disorders." ;
rdfs:subClassOf obo:CHEBI_50267 .
obo:BFO_0000008 a rdfs:Class ;
rdfs:label "temporal region"@en ;
rdfs:subClassOf obo:BFO_0000003 .
obo:PROCO_0000213 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.2.1 Manufacturers"@en ;
rdfs:comment "The document part of the common technical document regarding manufacturers" ;
rdfs:subClassOf obo:IAO_0000314 .
obo:CHMO_0001534 a rdfs:Class ;
rdfs:label "continuous distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a sample mixture are vaporised by the application of heat and then cooled by the action of cold water in a condenser. The distillation is ongoing with sample mixture being continuously added." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:CHMO_0001555 a rdfs:Class ;
rdfs:label "spray drying" ;
rdfs:comment "The removal of water from a liquid sample by pumping it through an atomiser (to produce a spray of fine droplets) then passing a hot gas (e.g. air or N2) through it." ;
rdfs:subClassOf obo:CHMO_0001549 .
obo:CHEBI_77746 a rdfs:Class ;
rdfs:label "human metabolite" ;
rdfs:comment "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." ;
rdfs:subClassOf obo:CHEBI_75768 .
obo:CHEBI_70982 a rdfs:Class ;
rdfs:label "reactive oxygen species generator" ;
rdfs:comment "Any entity used to generate reactive oxygen species." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHMO_0001652 a rdfs:Class ;
rdfs:label "grinding" ;
rdfs:comment "The mechanical reduction of the particle size of a solid sample by attribution (friction), impact or cutting." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:BFO_0000002 a rdfs:Class ;
rdfs:label "continuant" ;
rdfs:comment "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ;
rdfs:subClassOf obo:BFO_0000001 .
obo:CHEBI_33559 a rdfs:Class ;
rdfs:label "s-block element atom" ;
rdfs:subClassOf obo:CHEBI_33250 .
obo:CHEBI_36357 a rdfs:Class ;
rdfs:label "polyatomic entity" ;
rdfs:comment "Any molecular entity consisting of more than one atom." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:PROCO_0000286 a rdfs:Class ;
rdfs:label "competency question" ;
rdfs:comment "An objective specification for an ontology in the form of a user-focused question / query that identifies key concepts and their relationships that are normally formalized in first order logic of the ontology. They are also used to test the ontology by querying known instance data or by entailment on its axioms." ;
rdfs:subClassOf obo:IAO_0000005 , obo:IAO_0000102 .
a rdfs:Class ;
rdfs:label "sample role (preparation)" ;
rdfs:comment "A sample role (preparation) is a role of a material that is prepared for a bearing the sample role in an experiment. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:CHEBI_91015 a rdfs:Class ;
rdfs:label "corrosion inhibitor" ;
rdfs:comment "A chemical compound that, when added to a liquid or gas, decreases the corrosion rate of a material, typically a metal or an alloy." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHMO_0001657 a rdfs:Class ;
rdfs:label "wet grinding" ;
rdfs:comment "The mechanical reduction of the particle size of a solid sample by attribution (friction), impact or cutting in the presence of a small amount of liquid (which is not a solvent for the solid)." ;
rdfs:subClassOf obo:CHMO_0001652 .
obo:CHEBI_33675 a rdfs:Class ;
rdfs:label "p-block molecular entity" ;
rdfs:comment "A main group molecular entity that contains one or more atoms of a p-block element." ;
rdfs:subClassOf obo:CHEBI_33579 .
obo:PROCO_0000043 a rdfs:Class ;
rdfs:label "stir rate profile" ;
rdfs:comment "A process profile that represents the number of revolution of stirs given a specific time period" ;
rdfs:subClassOf obo:PROCO_0000047 .
obo:IAO_0000064 a rdfs:Class ;
rdfs:label "algorithm"@en ;
rdfs:comment "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata."@en ;
rdfs:subClassOf obo:IAO_0000104 .
obo:CHEBI_23357 a rdfs:Class ;
rdfs:label "cofactor" ;
rdfs:comment "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." ;
rdfs:subClassOf obo:CHEBI_52206 .
obo:CHEBI_23924 a rdfs:Class ;
rdfs:label "enzyme inhibitor" ;
rdfs:comment "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." ;
rdfs:subClassOf obo:CHEBI_35222 , obo:CHEBI_52206 .
obo:CHEBI_35223 a rdfs:Class ;
rdfs:label "catalyst" ;
rdfs:comment "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." ;
rdfs:subClassOf obo:CHEBI_51086 .
a rdfs:Class ;
rdfs:label "to change" ;
rdfs:comment "To adjust the flow of energy, signal, or material in a predetermined and fixed manner. [NIST]" ;
rdfs:subClassOf , .
obo:CHEBI_24835 a rdfs:Class ;
rdfs:label "inorganic molecular entity" ;
rdfs:comment "A molecular entity that contains no carbon." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:PROCO_0000205 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.1.2 Structure"@en ;
rdfs:comment "The drug substance structure section of the CTA" ;
rdfs:subClassOf obo:IAO_0000314 .
obo:CHEBI_51143 a rdfs:Class ;
rdfs:label "nitrogen molecular entity" ;
rdfs:subClassOf obo:CHEBI_33302 .
obo:CHEBI_52217 a rdfs:Class ;
rdfs:label "pharmaceutical" ;
rdfs:comment "Any substance introduced into a living organism with therapeutic or diagnostic purpose." ;
rdfs:subClassOf obo:CHEBI_33232 .
obo:OBI_0200174 a rdfs:Class ;
rdfs:label "curve fitting objective"@en ;
rdfs:comment "A curve fitting objective is a data transformation objective in which the aim is to find a curve which matches a series of data points and possibly other constraints."@en ;
rdfs:subClassOf obo:OBI_0200166 .
obo:CHEBI_24874 a rdfs:Class ;
rdfs:label "iron ionophore" ;
rdfs:comment "Any ionophore capable of transportation of iron ions across membranes." ;
rdfs:subClassOf obo:CHEBI_24869 .
obo:CHEBI_50910 a rdfs:Class ;
rdfs:label "neurotoxin" ;
rdfs:comment "A poison that interferes with the functions of the nervous system." ;
rdfs:subClassOf obo:CHEBI_52209 , obo:CHEBI_64909 .
a rdfs:Class ;
rdfs:label "portion of mixed material" ;
rdfs:comment "An portion of mixed material is a material entity that consists of different kinds of grains if you inspect it at a higher level of granularity. [Allotrope]" ;
rdfs:subClassOf obo:CHMO_0000993 .
obo:CHEBI_37407 a rdfs:Class ;
rdfs:label "cyclic ether" ;
rdfs:comment "Any ether in which the oxygen atom forms part of a ring." ;
rdfs:subClassOf obo:CHEBI_25698 , obo:CHEBI_38104 .
obo:CHEBI_78298 a rdfs:Class ;
rdfs:label "environmental contaminant" ;
rdfs:comment "Any minor or unwanted substance introduced into the environment that can have undesired effects." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:PROCO_0000028 a rdfs:Class ;
rdfs:label "temperature profile in synthesis process"@en ;
rdfs:comment "A process profile that is about temperature." ;
rdfs:subClassOf obo:PROCO_0000047 .
obo:PROCO_0000060 a rdfs:Class ;
rdfs:label "rate constant" ;
rdfs:comment "Numerical parameter that quantifies the velocity of a chemical reaction. This parameter encompasses all the contributions to the velocity except the quantity of the reactants." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "potential impurity role" ;
rdfs:comment "An impurity role for a material that theoretically can arise during manufacture or storage. It may or may not actually appear in the new drug substance. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:CHEBI_50566 a rdfs:Class ;
rdfs:label "nitric oxide donor" ;
rdfs:comment "An agent, with unique chemical structure and biochemical requirements, which generates nitric oxide." ;
rdfs:subClassOf obo:CHEBI_17891 .
obo:PROCO_0000199 a rdfs:Class ;
rdfs:label "chemical structure"@en ;
rdfs:comment "The structure of a chemical entity in terms of its molecular geometry and electronic structure." ;
rdfs:subClassOf obo:PATO_0002182 .
obo:PROCO_0000100 a rdfs:Class ;
rdfs:label "process monitoring"@en ;
rdfs:comment "A planned process of measuring a quality of a material associated with a process." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:OBI_0000376 a rdfs:Class ;
rdfs:label "synthesizing function"@en ;
rdfs:comment "A synthesizing function is a function to assemble new output materials from distinct input materials. The output materials typically consist of chemically distinct monomeric objects or object aggregate polymers." ;
rdfs:subClassOf obo:BFO_0000034 .
obo:PROCO_0000224 a rdfs:Class ;
rdfs:label "MCASE Mutagen Prediction" ;
rdfs:comment "An is-silico modeling based on MCASE that determines the risk of a chemical being a mutagenic impurity" ;
rdfs:subClassOf obo:PROCO_0000159 .
obo:CHEBI_52206 a rdfs:Class ;
rdfs:label "biochemical role" ;
rdfs:comment "A biological role played by the molecular entity or part thereof within a biochemical context." ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:PROCO_0000275 a rdfs:Class ;
rdfs:label "one-factor-at-a-time experimental design" ;
rdfs:comment "An experimental design involving the testing of factors, or causes, one at a time instead of multiple factors simultaneously." ;
rdfs:subClassOf obo:PROCO_0000276 .
obo:PROCO_0000069 a rdfs:Class ;
rdfs:label "crystalline state"@en ;
rdfs:comment "A physical quality indicating the structural order of a solid in which its atoms or molecules are arranged in a regular, periodic manner.[wikipedia]" ;
rdfs:subClassOf .
obo:OBI_0000571 a rdfs:Class ;
rdfs:label "manufacturer role" ;
rdfs:comment "Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process. [OBI]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PROCO_0000076 a rdfs:Class ;
rdfs:label "process environmental factor"@en ;
rdfs:comment "A process chemistry datum quantifying the environmental impact of a synthetic reaction, and is computed by the ratio of the total mass of waste generated in the synthetic scheme to the mass of product isolated." ;
rdfs:subClassOf obo:PROCO_0000295 .
obo:CHMO_0001641 a rdfs:Class ;
rdfs:label "micro-filtration" ;
rdfs:comment "A pressure-driven membrane-based separation process in which particles and dissolved macromolecules larger than 0.1 micrometre are rejected." ;
rdfs:subClassOf obo:CHMO_0001640 .
obo:CHEBI_18379 a rdfs:Class ;
rdfs:label "nitrile" ;
rdfs:comment "A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it." ;
rdfs:subClassOf obo:CHEBI_23424 .
obo:CHEBI_16670 a rdfs:Class ;
rdfs:label "peptide" ;
rdfs:comment "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." ;
rdfs:subClassOf obo:CHEBI_33839 .
obo:PROCO_0000155 a rdfs:Class ;
rdfs:label "sphenoidal"@en ;
rdfs:comment "A monoclinic crystal class with two nonparallel faces symmetrical to a 2- or 4-fold axis of symmetry that has enantiomorphic and polar point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_75787 a rdfs:Class ;
rdfs:label "prokaryotic metabolite" ;
rdfs:comment "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." ;
rdfs:subClassOf obo:CHEBI_25212 .
a rdfs:Class ;
rdfs:label "reaction mixture role" ;
rdfs:comment "A reaction mixture role is a role of a chemical mixture undergoing some chemical reaction. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000093 a rdfs:Class ;
rdfs:label "process chemistry workflow plan"@en ;
rdfs:comment "A plan specification that specifies a process chemistry workflow consisting of a series of unit operations." ;
rdfs:subClassOf obo:IAO_0000104 .
obo:PROCO_0000036 a rdfs:Class ;
rdfs:label "charging material"@en ;
rdfs:comment "A unit operation of adding a reagent or starting material to a chemical reaction" ;
rdfs:subClassOf obo:PROCO_0000051 .
obo:OBI_0000809 a rdfs:Class ;
rdfs:label "amplified DNA" ;
rdfs:comment "DNA that has been produced in an enzymatic amplification process" ;
rdfs:subClassOf obo:CHEBI_16991 , obo:OBI_0000047 .
obo:OBI_0000441 a rdfs:Class ;
rdfs:label "assay objective"@en ;
rdfs:comment "an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role)"@en ;
rdfs:subClassOf obo:IAO_0000005 .
obo:OBI_0200072 a rdfs:Class ;
rdfs:label "curve fitting data transformation"@en ;
rdfs:comment "A curve fitting is a data transformation that has objective curve fitting and that consists of finding a curve which matches a series of data points and possibly other constraints."@en ;
rdfs:subClassOf obo:OBI_0200000 .
obo:CHEBI_15339 a rdfs:Class ;
rdfs:label "acceptor" ;
rdfs:comment "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHMO_0002159 a rdfs:Class ;
rdfs:label "Verneuil process" ;
rdfs:comment "A method for preparing synthetic gemstones. A finely powdered sample is melted in an hydrogen-oxygen flame (2000 °C) and crystallising the melted droplets on a boule (a single crystal)." ;
rdfs:subClassOf obo:CHMO_0002224 .
obo:CHMO_0002219 a rdfs:Class ;
rdfs:label "vacuum sublimation" ;
rdfs:comment "A technique for purifying solid samples by heating the sample under vacuum. The sample sublimes and the vapours condense as a purified compound on a cooled surface, leaving the non-volatile residue impurities behind." ;
rdfs:subClassOf obo:CHMO_0002217 .
obo:CHEBI_79389 a rdfs:Class ;
rdfs:label "monovalent inorganic anion" ;
rdfs:comment "Any inorganic anion with a valency of one." ;
rdfs:subClassOf obo:CHEBI_24834 .
obo:CHEBI_17891 a rdfs:Class ;
rdfs:label "donor" ;
rdfs:comment "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:PROCO_0000257 a rdfs:Class ;
rdfs:label "ditrigonal-scalenohedral" ;
rdfs:comment "8-faced (tetragonal) or 12-faced (hexagonal) closed form in which the faces are grouped in symmetrical pairs with centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_32988 a rdfs:Class ;
rdfs:label "amide" ;
rdfs:comment "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." ;
rdfs:subClassOf obo:CHEBI_51143 .
a rdfs:Class ;
rdfs:label "gas" ;
rdfs:comment "A state of matter that is a compressible fluid. Not only will a gas conform to the shape of its container but it will also expand to fill the container. In a gas, the molecules have enough kinetic energy so that the effect of intermolecular forces is small (or zero for an ideal gas), and the typical distance between neighboring molecules is much greater than the molecular size. A gas has no definite shape or volume, but occupies the entire container in which it is confined. [Wikipedia]" ;
rdfs:subClassOf .
obo:CHMO_0001599 a rdfs:Class ;
rdfs:label "gas–liquid extraction" ;
rdfs:comment "A flotation process in which the material of interest, adsorbed on the surface of gas bubbles in a liquid, is collected on an upper layer of immiscible liquid." ;
rdfs:subClassOf obo:CHMO_0001598 .
obo:FIX_0000369 a rdfs:Class ;
rdfs:label "thermodynamic reaction property" ;
rdfs:subClassOf obo:FIX_0000277 .
obo:PROCO_0000006 a rdfs:Class ;
rdfs:label "equation"@en ;
rdfs:comment "An information content entity that asserts the equality of two expressions." ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHEBI_25078 a rdfs:Class ;
rdfs:label "luciferin" ;
rdfs:comment "A low-molecular-mass compound present in bioluminescent organisms that emits light when oxidized in presence of enzyme luciferase." ;
rdfs:subClassOf obo:CHEBI_52216 .
obo:PR_000000001 a rdfs:Class ;
rdfs:label "protein" ;
rdfs:comment "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." ;
rdfs:subClassOf obo:CHEBI_16670 .
a rdfs:Class ;
rdfs:label "debris role" ;
rdfs:comment "Debris is a role of material to be waste. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:CHMO_0001539 a rdfs:Class ;
rdfs:label "steam distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a sample mixture are vaporised by bubbling steam through it and then cooled by the action of cold water in a condenser." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:PROCO_0000195 a rdfs:Class ;
rdfs:label "Erlenmeyer flask"@en ;
rdfs:comment "An Erlenmeyer flask or conical flask is a type of laboratory flask which features a flat bottom, a conical body, and a cylindrical neck." ;
rdfs:subClassOf obo:PROCO_0000191 .
obo:BFO_0000019 a rdfs:Class ;
rdfs:label "quality"@en ;
rdfs:subClassOf obo:BFO_0000020 .
obo:CHEBI_50903 a rdfs:Class ;
rdfs:label "carcinogenic agent" ;
rdfs:comment "A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities." ;
rdfs:subClassOf obo:CHEBI_52209 .
obo:PROCO_0000166 a rdfs:Class ;
rdfs:label "assessed volatility purge factor" ;
rdfs:comment "An assessed purge factor based on the relative boiling point of the impurity to the reaction solvent and therefore its propensity to be purged in the headspace of steps to which the impurity is subjected.." ;
rdfs:subClassOf obo:PROCO_0000070 .
obo:PROCO_0000228 a rdfs:Class ;
rdfs:label "steady-state approximation analysis" ;
rdfs:comment "A mechanistic and kinetic determination that involves setting the rate of change of a reaction intermediate in a reaction mechanism equal to zero so that the kinetic equations can be simplified by setting the rate of formation of the intermediate equal to the rate of its destruction." ;
rdfs:subClassOf obo:PROCO_0000085 .
obo:CHEBI_25699 a rdfs:Class ;
rdfs:label "organic ion" ;
rdfs:subClassOf obo:CHEBI_24870 , obo:CHEBI_50860 .
obo:CHEBI_47032 a rdfs:Class ;
rdfs:label "1,4-dioxane" ;
rdfs:comment "A dioxane with oxygen atoms at positions 1 and 4." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_46923 .
a rdfs:Class ;
rdfs:label "material cleaned role" ;
rdfs:comment "Material that is undergoing a cleaning process. [Allotrope]" ;
rdfs:subClassOf , .
obo:CHMO_0001577 a rdfs:Class ;
rdfs:label "extraction" ;
rdfs:comment "The transfer of a solute from a liquid phase to another immiscible or partially-miscible liquid phase in contact with it." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:CHEBI_33282 a rdfs:Class ;
rdfs:label "antibacterial agent" ;
rdfs:comment "A substance (or active part thereof) that kills or slows the growth of bacteria." ;
rdfs:subClassOf obo:CHEBI_33281 .
obo:CHMO_0002208 a rdfs:Class ;
rdfs:label "solvent evaporation" ;
rdfs:comment "The removal of solvent from a sample, usually by the application of heat." ;
rdfs:subClassOf obo:CHMO_0001574 .
obo:CHEBI_37622 a rdfs:Class ;
rdfs:label "carboxamide" ;
rdfs:comment "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." ;
rdfs:subClassOf obo:CHEBI_33256 , obo:CHEBI_35352 , obo:CHEBI_36963 .
obo:CHMO_0001549 a rdfs:Class ;
rdfs:label "sample drying" ;
rdfs:comment "The process of removing a solvent from a substance." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:PROCO_0000053 a rdfs:Class ;
rdfs:label "process mass intensity"@en ;
rdfs:comment "The process mass intensity (PMI) calculates the ratio of the total mass of materials to the mass of the isolated product" ;
rdfs:subClassOf obo:PROCO_0000295 .
obo:PROCO_0000064 a rdfs:Class ;
rdfs:label "antisolvent role"@en ;
rdfs:comment "The role of a solvent in a precipitation or crystallization in which the solute of a solution is sparingly soluble to induce its solidification." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_27207 a rdfs:Class ;
rdfs:label "univalent carboacyl group" ;
rdfs:comment "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." ;
rdfs:subClassOf obo:CHEBI_37838 .
obo:PROCO_0000058 a rdfs:Class ;
rdfs:label "product filing milestone"@en ;
rdfs:comment "A process boundary that represents a milestone of filing the documentation required to obtain regulatory approval to sell a new product." ;
rdfs:subClassOf obo:BFO_0000035 .
obo:PROCO_0000047 a rdfs:Class ;
rdfs:label "quality process profile"@en ;
rdfs:comment "A process profile that tracks the quality of some process participant." ;
rdfs:subClassOf obo:BFO_0000144 .
obo:PROCO_0000289 a rdfs:Class ;
rdfs:label "product stream" ;
rdfs:comment "A portion of material to be further processed that has an ingredient a material with the role of product." ;
rdfs:subClassOf obo:CHMO_0000993 .
obo:CHEBI_143130 a rdfs:Class ;
rdfs:label "impurity" ;
rdfs:comment "A chemical role played by any unwanted chemical substance inside a confined amount of liquid, gas, or solid, which differs from the chemical composition of the material or compound. For example, an impurity can be an undesired by-product of a chemical reaction or manufacturing process, a drug contaminant, or can be created upon degradation during storage." ;
rdfs:subClassOf obo:CHEBI_51086 .
a rdfs:Class ;
rdfs:label "limiting reagent role" ;
rdfs:comment "A reagent role of the material with the least mole quantity in a chemical process and as such limits the amount of product that can be formed. [Allotrope]" ;
rdfs:subClassOf obo:OBI_0000086 .
obo:PROCO_0000012 a rdfs:Class ;
rdfs:label "synthesis reaction time"@en ;
rdfs:comment "A temporal region that describes the length of time that a synthesis occurs." ;
rdfs:subClassOf obo:BFO_0000008 .
obo:BFO_0000035 a rdfs:Class ;
rdfs:label "process boundary"@en ;
rdfs:comment "p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])"@en ;
rdfs:subClassOf obo:BFO_0000003 .
obo:CHEBI_74783 a rdfs:Class ;
rdfs:label "astringent" ;
rdfs:comment "A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions." ;
rdfs:subClassOf obo:CHEBI_23888 .
obo:PROCO_0000086 a rdfs:Class ;
rdfs:label "process validation"@en ;
rdfs:comment "A planned process of demonstrating that a process produces product of adequate quality and yield through the definition of the design space or risk assessments." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHEBI_77521 a rdfs:Class ;
rdfs:label "thermal degradation product" ;
rdfs:comment "Any product obtained as a result of thermally induced non-enzymatic degradation." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHMO_0001689 a rdfs:Class ;
rdfs:label "affinity precipitation" ;
rdfs:comment "The selective sedimentation of a solid material (a 'precipitate') from a liquid sample containing a ligand and a target protein. The precipitate evolves after the application of a suitable stimulus (e.g. Ca2+ or Ba2+)." ;
rdfs:subClassOf obo:CHMO_0001688 .
obo:CHEBI_25805 a rdfs:Class ;
rdfs:label "oxygen atom" ;
rdfs:subClassOf obo:CHEBI_25585 , obo:CHEBI_33303 .
obo:CHEBI_27594 a rdfs:Class ;
rdfs:label "carbon atom" ;
rdfs:subClassOf obo:CHEBI_25585 , obo:CHEBI_33306 .
a rdfs:Class ;
rdfs:label "kinetic constant" ;
rdfs:comment "Numerical parameter that quantifies the velocity of a chemical reaction. This parameter encompasses all the contributions to the velocity except the quantity of the reactants." ;
rdfs:subClassOf .
obo:PROCO_0000234 a rdfs:Class ;
rdfs:label "differential kinetic measurement" ;
rdfs:comment "A kinetic determination method that measures reaction rate directly. (d[]/dt)" ;
rdfs:subClassOf obo:PROCO_0000085 .
obo:PROCO_0000220 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.3.1 Elucidation of Structure and other Characteristics" ;
rdfs:comment """The document part of the common technical document that provides confirmation of structure based on, for example, synthetic route and spectral analyses should be provided. Information such as the potential for isomerism, the identification of stereochemistry, or the potential for forming polymorphs.
Reference ICH guidance Q6A.""" ;
rdfs:subClassOf obo:IAO_0000314 .
obo:CHEBI_50907 a rdfs:Class ;
rdfs:label "deaminating agent" ;
rdfs:comment "A deaminating agent is a role played by a chemical agent which exhibits the capability of causing the loss of an amine functional group on another molecular entity (e.g. DNA or protein)." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_50313 a rdfs:Class ;
rdfs:label "onium cation" ;
rdfs:comment "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." ;
rdfs:subClassOf obo:CHEBI_50312 .
obo:CHEBI_33937 a rdfs:Class ;
rdfs:label "macronutrient" ;
rdfs:comment "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." ;
rdfs:subClassOf obo:CHEBI_33284 .
a rdfs:Class ;
rdfs:label "localizing" ;
rdfs:comment "A processing that affects the spatial location or orientation of some participants. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000253 a rdfs:Class ;
rdfs:label "trigonal-pyramidal" ;
rdfs:comment "3-faced form where all faces are related by a 3-fold rotation axis with polar point and enantiomorphic point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
a rdfs:Class ;
rdfs:label "drying role" ;
rdfs:comment "A drying role role is a role realized in some drying process. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PROCO_0000302 a rdfs:Class ;
rdfs:label "Arhennius equation" ;
rdfs:comment "An equation for the temperature dependence of reaction rates used in determining rate of chemical reactions and for calculation of energy of activation." ;
rdfs:subClassOf obo:PROCO_0000006 .
obo:CHEBI_64709 a rdfs:Class ;
rdfs:label "organic acid" ;
rdfs:comment "Any organic molecular entity that is acidic and contains carbon in covalent linkage." ;
rdfs:subClassOf obo:CHEBI_50860 .
obo:PROCO_0000146 a rdfs:Class ;
rdfs:label "ionic salt"@en ;
rdfs:comment "A chemical substance composed of ions held together by electrostatic forces termed ionic bonding." ;
rdfs:subClassOf obo:PROCO_0000141 .
obo:CHEBI_33608 a rdfs:Class ;
rdfs:label "hydrogen molecular entity" ;
rdfs:subClassOf obo:CHEBI_33674 .
obo:CHMO_0002160 a rdfs:Class ;
rdfs:label "Bridgeman technique" ;
rdfs:comment "A method of growing a single crystal 'ingot' or 'boule'. The polycrystalline sample is heated in a container above its melting point and slowly cooled from one end where a seed crystal is located. Single crystal material is then progressively formed along the length of the container." ;
rdfs:subClassOf obo:CHMO_0002224 .
obo:CHEBI_26912 a rdfs:Class ;
rdfs:label "oxolanes" ;
rdfs:comment "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." ;
rdfs:subClassOf obo:CHEBI_25693 , obo:CHEBI_38104 .
a rdfs:Class ;
rdfs:label "state of matter" ;
rdfs:comment "A state of matter is a quality of material that is one of the distinct forms in which matter can exist. Four states of matter are observable in everyday life: solid, liquid, gas, and plasma. Many other states are known to exist only in extreme situations, such as Bose-Einstein condensates, neutron-degenerate matter, and quark-gluon plasma, which only occur in situations of extreme cold, extreme density, and extremely high-energy color-charged matter respectively. [Wikipedia]" ;
rdfs:subClassOf obo:PATO_0000051 .
obo:CHEBI_33696 a rdfs:Class ;
rdfs:label "nucleic acid" ;
rdfs:comment "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." ;
rdfs:subClassOf obo:CHEBI_33839 .
obo:CHEBI_35352 a rdfs:Class ;
rdfs:label "organonitrogen compound" ;
rdfs:comment "Any heteroorganic entity containing at least one carbon-nitrogen bond." ;
rdfs:subClassOf obo:CHEBI_33285 , obo:CHEBI_51143 .
obo:CHEBI_73335 a rdfs:Class ;
rdfs:label "ultraviolet filter" ;
rdfs:comment "A photochemical role realized in the absorption of ultraviolet light, for example to protect skin cells from damage." ;
rdfs:subClassOf obo:CHEBI_52215 .
obo:PROCO_0000054 a rdfs:Class ;
rdfs:label "polymer"@en ;
rdfs:comment "A substance or material consisting of very large molecules, or macromolecules, composed of many repeating subunits." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:PROCO_0000135 a rdfs:Class ;
rdfs:label "unit cell crystal density"@en ;
rdfs:comment "A unit cell quality indicating the density of the compound in the unit cell" ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:PROCO_0000162 a rdfs:Class ;
rdfs:label "ICH Q11 Guidance for Development and Manufacture of Drug Substances"@en ;
rdfs:comment "An ICH Guidance for developing and understanding the manufacturing process of the drug substance." ;
rdfs:subClassOf obo:PROCO_0000136 .
obo:PROCO_0000151 a rdfs:Class ;
rdfs:label "solid dispersion"@en ;
rdfs:comment "A heterogenous mixture in which one or more components is dispersed in a solid matrix" ;
rdfs:subClassOf .
obo:CHEBI_38496 a rdfs:Class ;
rdfs:label "electron-transport chain inhibitor" ;
rdfs:subClassOf obo:CHEBI_76932 .
obo:CHEBI_39011 a rdfs:Class ;
rdfs:label "Good's buffer substance" ;
rdfs:comment "Any member of a collection of zwitterionic buffer substances selected or devised for suitability in experimental biological systems according to a number of predetermined criteria. Named after Dr. Norman Good." ;
rdfs:subClassOf obo:CHEBI_35225 .
obo:PROCO_0000245 a rdfs:Class ;
rdfs:label "tetartoidal" ;
rdfs:comment "General cubic forms which only has 3-fold axes and 2-fold axes with no mirror plane with enantiomorphic point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
a rdfs:Class ;
rdfs:label "degradation product role" ;
rdfs:comment "A degradation product is an impurity resulting from a chemical change in the drug substance brought about during manufacture and/or storage of the new drug product by the effect of, for example, light, temperature, pH, water, or by reaction with an excipient and/or the immediate container closure system. [ICH-Q3B]" ;
rdfs:subClassOf .
obo:PROCO_0000191 a rdfs:Class ;
rdfs:label "flask"@en ;
rdfs:comment "Flasks are narrow-necked glass containers, typically conical or spherical, used in a laboratory to hold reagents or samples." ;
rdfs:subClassOf .
obo:CHEBI_33839 a rdfs:Class ;
rdfs:label "macromolecule" ;
rdfs:comment "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:CHEBI_63490 a rdfs:Class ;
rdfs:label "explosive" ;
rdfs:comment "A substance capable of undergoing rapid and highly exothermic decomposition." ;
rdfs:subClassOf obo:CHEBI_51086 .
a rdfs:Class ;
rdfs:label "molecular mass (molecular quality)" ;
rdfs:comment "Molecular mass is a molecular quality inhered in a molecular entity that expresses its mass relative to 1/12 of the mass of an unbound neutral atom of carbon-12 in its nuclear and electronic ground state and at rest. [Allotrope]" ;
rdfs:subClassOf obo:PATO_0000125 , obo:PATO_0002182 .
obo:OBI_0000066 a rdfs:Class ;
rdfs:label "investigation"@en ;
rdfs:comment "a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s)."@en ;
rdfs:subClassOf obo:OBI_0000011 .
a rdfs:Class ;
rdfs:label "facet" ;
rdfs:comment "A facet is a partial information that contains an aspect of some information content entity or parts of it when participating in some process. The facet abstracts of the concrete representation of this aspect of information. [Allotrope]" ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PROCO_0000099 a rdfs:Class ;
rdfs:label "route related process"@en ;
rdfs:comment "A planned process about a synthetic route" ;
rdfs:subClassOf obo:OBI_0000011 .
obo:BFO_0000020 a rdfs:Class ;
rdfs:label "specifically dependent continuant"@en ;
rdfs:comment "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en ;
rdfs:subClassOf obo:BFO_0000002 .
obo:FIX_0000279 a rdfs:Class ;
rdfs:label "Gibbs free energy change" ;
rdfs:subClassOf obo:FIX_0000369 .
a rdfs:Class ;
rdfs:label "unspecified impurity role" ;
rdfs:comment "An impurity role that is limited by a general acceptance criterion, but not individually listed with its own specific acceptance criterion, in the new drug substance specification. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:CHEBI_36339 a rdfs:Class ;
rdfs:label "baryon" ;
rdfs:comment "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." ;
rdfs:subClassOf obo:CHEBI_36340 , obo:CHEBI_36344 .
obo:CHEBI_37838 a rdfs:Class ;
rdfs:label "carboacyl group" ;
rdfs:comment "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." ;
rdfs:subClassOf obo:CHEBI_22221 .
obo:CHEBI_33560 a rdfs:Class ;
rdfs:label "p-block element atom" ;
rdfs:comment "Any main group element atom belonging to the p-block of the periodic table." ;
rdfs:subClassOf obo:CHEBI_33318 .
obo:PROCO_0000018 a rdfs:Class ;
rdfs:label "quality specification"@en ;
rdfs:comment "A directive information entity that species the acceptable range of values associated with a material quality" ;
rdfs:subClassOf obo:IAO_0000033 .
obo:IAO_0000578 a rdfs:Class ;
rdfs:label "centrally registered identifier"@en ;
rdfs:comment "An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs."@en ;
rdfs:subClassOf obo:IAO_0000030 , obo:IAO_0020000 .
obo:CHEBI_36856 a rdfs:Class ;
rdfs:label "hydrogen isocyanide" ;
rdfs:subClassOf obo:CHEBI_33405 .
obo:FIX_0000280 a rdfs:Class ;
rdfs:label "Gibbs free energy of activation" ;
rdfs:comment "The activation energy (Ea) of a reaction is the magnitude of the potential barrier (sometimes called the energy barrier) separating minima of the potential energy surface pertaining to the initial and final thermodynamic state. For a chemical reaction to proceed at a reasonable rate, the temperature of the system should be high enough such that there exists an appreciable number of molecules with translational energy equal to or greater than the activation energy." ;
rdfs:subClassOf obo:FIX_0000369 .
a rdfs:Class ;
rdfs:label "heating device" ;
rdfs:comment "A device used for heating something. [Allotrope]" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "rinse solution role" ;
rdfs:comment "The rinse solution role is a cleaning agent role of a fluid used to flush something in order to remove contaminants. [Allotrope]" ;
rdfs:subClassOf .
obo:CHEBI_131604 a rdfs:Class ;
rdfs:label "Mycoplasma genitalium metabolite" ;
rdfs:comment "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium." ;
rdfs:subClassOf obo:CHEBI_76969 .
obo:CHMO_0001904 a rdfs:Class ;
rdfs:label "supercritical fluid method" ;
rdfs:comment "Any material processing method that uses a supercritical fluid." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:PROCO_0000278 a rdfs:Class ;
rdfs:label "process safety" ;
rdfs:comment "A planned process of understanding of the hazards of a chemical process and developing methods to safely manage and minimize the risks of the process." ;
rdfs:subClassOf obo:OBI_0000011 .
a rdfs:Class ;
rdfs:label "effective catalytic rate" ;
rdfs:comment "Under nutrient limited conditions, it may be assumed that enzymes are operating below their maximal capacity (Kcat). Keff represents the lumped turnover rate of a reaction, expressed in units per time." ;
rdfs:subClassOf .
obo:PROCO_0000123 a rdfs:Class ;
rdfs:label "tetragonal unit cell"@en ;
rdfs:comment "A unit cell that has three perpendicular axes, two of equal length" ;
rdfs:subClassOf obo:PROCO_0000120 .
obo:CHEBI_24026 a rdfs:Class ;
rdfs:label "fatty alcohol" ;
rdfs:comment "An aliphatic alcohol consisting of a chain of 3 to greater than 27 carbon atoms. Fatty alcohols may be saturated or unsaturated and may be branched or unbranched." ;
rdfs:subClassOf obo:CHEBI_18059 , obo:CHEBI_30879 .
obo:PROCO_0000297 a rdfs:Class ;
rdfs:label "factorial analysis" ;
rdfs:comment "Chemometric method used to describe variability among observed, correlated variables in terms of a potentially lower number of unobserved variables called factors. . The observed variables are modelled as linear combinations of the potential factors, plus \"error\" terms." ;
rdfs:subClassOf obo:PROCO_0000296 .
obo:CHEBI_35107 a rdfs:Class ;
rdfs:label "azane" ;
rdfs:comment "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." ;
rdfs:subClassOf obo:CHEBI_35106 .
obo:PROCO_0000042 a rdfs:Class ;
rdfs:label "GMP specification of synthetic process"@en ;
rdfs:comment "A plan specification that specifies the action and objective of a synthetic process, as defined in CFR - Code of Federal Regulations Title 21." ;
rdfs:subClassOf obo:PROCO_0000056 .
obo:PROCO_0000183 a rdfs:Class ;
rdfs:label "coil condenser"@en ;
rdfs:comment "A condensor consisting of a straight tube containing an internal spiral coil through which coolant flows." ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:CHMO_0001001 a rdfs:Class ;
rdfs:label "column chromatography" ;
rdfs:comment "A chromatography method where the stationary bed is within a tube (of standard length 25 cm). The particles of the solid stationary phase or support coated with a liquid stationary phase may fill the whole inside volume of the tube (packed column) or be concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube (open-tubular column)." ;
rdfs:subClassOf obo:CHMO_0001000 .
obo:CHMO_0001690 a rdfs:Class ;
rdfs:label "co-precipitation" ;
rdfs:comment "The simultaneous precipitation of a normally soluble component with a macro-component from the same solution by the formation of mixed crystals, by adsorption, occlusion or mechanical entrapment." ;
rdfs:subClassOf obo:CHMO_0001688 .
obo:GO_0032991 a rdfs:Class ;
rdfs:label "protein-containing complex" ;
rdfs:comment "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PROCO_0000239 a rdfs:Class ;
rdfs:label "domatic" ;
rdfs:comment "A 2- faced open form monoclinic crystal with polar point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
a rdfs:Class ;
rdfs:label "containing state" ;
rdfs:comment "The state of keeping a flow within spatial limits. [Allotrope]" ;
rdfs:subClassOf .
obo:CHEBI_33233 a rdfs:Class ;
rdfs:label "fundamental particle" ;
rdfs:comment "A particle not known to have substructure." ;
rdfs:subClassOf obo:CHEBI_36342 .
obo:PROCO_0000227 a rdfs:Class ;
rdfs:label "process analytical technology" ;
rdfs:comment "A process chemistry workflow plan that utilizes online and at-line measurements to understand chemical processes by defining and monitoring ..." ;
rdfs:subClassOf obo:PROCO_0000093 .
obo:CHMO_0002863 a rdfs:Class ;
rdfs:label "dispersive solid phase extraction" ;
rdfs:subClassOf obo:CHMO_0001583 .
obo:CHEBI_37022 a rdfs:Class ;
rdfs:label "amino-acid anion" ;
rdfs:subClassOf obo:CHEBI_29067 , obo:CHEBI_35352 .
obo:PROCO_0000172 a rdfs:Class ;
rdfs:label "Bunsen burner"@en ;
rdfs:comment "A heating device (environmental control device) that utilizes an open flame for heating." ;
rdfs:subClassOf .
obo:CHEBI_36342 a rdfs:Class ;
rdfs:label "subatomic particle" ;
rdfs:comment "A particle smaller than an atom." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:PROCO_0000029 a rdfs:Class ;
rdfs:label "starting material for synthesis"@en ;
rdfs:comment "A chemcial entity with the role starting material in a synthesis." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:PROCO_0000206 a rdfs:Class ;
rdfs:label "chemical drawing"@en ;
rdfs:comment "A two or three dimensional representation of a chemical structure." ;
rdfs:subClassOf .
obo:CHEBI_36389 a rdfs:Class ;
rdfs:label "saturated organic heteromonocyclic parent" ;
rdfs:subClassOf obo:CHEBI_25693 , obo:CHEBI_36388 .
obo:PROCO_0000264 a rdfs:Class ;
rdfs:label "dihexagonal-dipyramidal" ;
rdfs:comment "24-faced form with faces related by a 6-fold axis with a perpendicular mirror plane and centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHMO_0002524 a rdfs:Class ;
rdfs:label "dual-phase extraction" ;
rdfs:comment "An extraction method for soil samples that uses a high-vacuum system to remove liquid and gas from low-permeability or heterogeneous soil. By removing water from the sample (liquid-phase extraction) the water table is lowered exposing the solid sample to vapor-phase extraction." ;
rdfs:subClassOf obo:CHMO_0001577 .
obo:CHEBI_24433 a rdfs:Class ;
rdfs:label "group" ;
rdfs:comment "A defined linked collection of atoms or a single atom within a molecular entity." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:CHMO_0001945 a rdfs:Class ;
rdfs:label "gas antisolvent technique" ;
rdfs:comment "A technique where a solid sample is first partially dissolved in a organic solvent in a vessel. The solution is then pressurised with a dense gas or supercritical fluid resulting in precipitation of the solid as a fine powder." ;
rdfs:subClassOf obo:CHMO_0001904 .
obo:OBI_0000415 a rdfs:Class ;
rdfs:label "polymerase chain reaction"@en ;
rdfs:comment "PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified."@en ;
rdfs:subClassOf obo:OBI_0600058 .
obo:PROCO_0000188 a rdfs:Class ;
rdfs:label "environmental control device"@en ;
rdfs:comment "A device for controlling the environment of a particular space" ;
rdfs:subClassOf .
obo:PROCO_0000258 a rdfs:Class ;
rdfs:label "hexagonal-pyrimidal" ;
rdfs:comment "6-faced form where all faces are related by a 6 axis having polar point and enantiomorphic point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_33663 a rdfs:Class ;
rdfs:label "cyclic hydrocarbon" ;
rdfs:subClassOf obo:CHEBI_24632 , obo:CHEBI_33598 .
obo:CHEBI_33597 a rdfs:Class ;
rdfs:label "homocyclic compound" ;
rdfs:comment "A cyclic compound having as ring members atoms of the same element only." ;
rdfs:subClassOf obo:CHEBI_33595 .
a rdfs:Class ;
rdfs:label "controlling" ;
rdfs:comment "Controlling is changing or regulating a flow in its magnitude. [NIST, Allotrope]" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "temporal measure" ;
rdfs:comment "Fundamental quantity of the measuring system used to sequence events, to compare the durations of events and the intervals between them, and to quantify the motions or the transformation of entities. The SI base unit for time is the SI second. The second is the duration of 9,192,631,770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom." ;
rdfs:subClassOf .
obo:CHEBI_35222 a rdfs:Class ;
rdfs:label "inhibitor" ;
rdfs:comment "A substance that diminishes the rate of a chemical reaction." ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:CHEBI_17654 a rdfs:Class ;
rdfs:label "electron acceptor" ;
rdfs:comment "A substance to which an electron may be transferred." ;
rdfs:subClassOf obo:CHEBI_15339 .
obo:CHEBI_33822 a rdfs:Class ;
rdfs:label "organic hydroxy compound" ;
rdfs:comment "An organic compound having at least one hydroxy group attached to a carbon atom." ;
rdfs:subClassOf obo:CHEBI_24651 , obo:CHEBI_50860 .
obo:CHMO_0002222 a rdfs:Class ;
rdfs:label "seeded sublimation" ;
rdfs:comment "A technique for growing crystals of SiC by heating a source (polycrystalline SiC or powder) at high temperature (1800-2600 °C) and low pressure in an Ar atmosphere causing it to sublime. The vapours then condense on a single crystal of SiC (the 'seed')." ;
rdfs:subClassOf obo:CHMO_0002224 .
obo:CHMO_0002852 a rdfs:Class ;
rdfs:label "spiking" ;
rdfs:comment "A material processing step that involves taking a test material with an adequately low background level of the intended analyte and mixing it with a known amount of analyte." ;
rdfs:subClassOf obo:OBI_0000094 .
a rdfs:Class ;
rdfs:label "device" ;
rdfs:comment "A device is an artifact that is designed to perform a function primarily by means of its mechanical or electrical nature. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PROCO_0000109 a rdfs:Class ;
rdfs:label "unit cell quality"@en ;
rdfs:comment "A molecular quality that describes the unit cell of the crystal lattice" ;
rdfs:subClassOf obo:BFO_0000019 .
obo:PROCO_0000031 a rdfs:Class ;
rdfs:label "chemical impurity"@en ;
rdfs:comment "Chemical substance that is inside a confined amount of liquid, gas, or solid, and differs from the chemical composition of the material or compound. Impurities are either naturally occurring or added during synthesis of a chemical or commercial product. During production, impurities may be purposely, accidentally, inevitably, or incidentally added into the substance." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:CHEBI_33303 a rdfs:Class ;
rdfs:label "chalcogen" ;
rdfs:comment "Any p-block element belonging to the group 16 family of the periodic table." ;
rdfs:subClassOf obo:CHEBI_33560 .
obo:CHEBI_77853 a rdfs:Class ;
rdfs:label "persistent organic pollutant" ;
rdfs:comment "Any environmental contaminant that is resistant to environmental degradation through photolytic, biological or chemical processes. Such substances can have significant impact on health and the environment, as they persist in the environment, bioaccumulate in animal tissue and so biomagnify in food chains." ;
rdfs:subClassOf obo:CHEBI_78298 .
obo:CHEBI_22695 a rdfs:Class ;
rdfs:label "base" ;
rdfs:comment "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." ;
rdfs:subClassOf obo:CHEBI_51086 .
a rdfs:Class ;
rdfs:label "heterogeneous mixture" ;
rdfs:comment "A heterogeneous mixture is a portion of mixed material that is not uniform in composition, but proportions of its components vary throughout the sample. [Wikipedia]" ;
rdfs:subClassOf .
obo:PROCO_0000217 a rdfs:Class ;
rdfs:label "specific rotation datum"@en ;
rdfs:comment "A scalar measurement datum that quantifies the measured change in orientation of monochromatic plane-polarized light, per unit distance–concentration product, as the light passes through a sample of a compound in solution." ;
rdfs:subClassOf obo:IAO_0000032 .
obo:PROCO_0000216 a rdfs:Class ;
rdfs:label "solution pH datum"@en ;
rdfs:comment "A scalar measurement datum that quantifies the measured pH of a saturated solution of a material at a specified temperature." ;
rdfs:subClassOf obo:IAO_0000032 .
obo:CHEBI_65255 a rdfs:Class ;
rdfs:label "food preservative" ;
rdfs:comment "Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes." ;
rdfs:subClassOf obo:CHEBI_64047 .
obo:IAO_0000003 a rdfs:Class ;
rdfs:label "measurement unit label"@en ;
rdfs:comment "A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure."@en ;
rdfs:subClassOf obo:IAO_0000009 .
obo:PROCO_0000280 a rdfs:Class ;
rdfs:label "Central Composite Design" ;
rdfs:comment """An experimental design consisting of three distinct sets of experimental runs:
A factorial (perhaps fractional) design in the factors studied, each having two levels;
A set of center points, experimental runs whose values of each factor are the medians of the values used in the factorial portion. This point is often replicated in order to improve the precision of the experiment;
A set of axial points, experimental runs identical to the centre points except for one factor, which will take on values both below and above the median of the two factorial levels, and typically both outside their range. All factors are varied in this way.""" ;
rdfs:subClassOf obo:PROCO_0000276 .
obo:CHEBI_82632 a rdfs:Class ;
rdfs:label "phytochrome chromophore" ;
rdfs:comment "A chromophore that is a linear tetrapyrrolic prosthetic group covalently attached to a large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far-red light absorbing form." ;
rdfs:subClassOf obo:CHEBI_23240 .
obo:OBI_0302886 a rdfs:Class ;
rdfs:label "centrifugation" ;
rdfs:comment "A process separating molecules by size or density using centrifugal forces generated by a spinning rotor. G-forces of several hundred thousand times gravity are generated in ultracentrifugation." ;
rdfs:subClassOf obo:OBI_0600014 .
obo:CHMO_0001610 a rdfs:Class ;
rdfs:label "supercritical fluid extraction" ;
rdfs:comment "The process of transferring a substance from any matrix to a liquid phase using a supercritical fluid." ;
rdfs:subClassOf obo:CHMO_0001598 .
obo:CHEBI_59740 a rdfs:Class ;
rdfs:label "nucleophilic reagent" ;
rdfs:comment "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." ;
rdfs:subClassOf obo:CHEBI_33893 , obo:CHEBI_39144 .
obo:PATO_0001574 a rdfs:Class ;
rdfs:label "flow rate" ;
rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's motion characteristic." ;
rdfs:subClassOf obo:PATO_0000001 .
obo:IAO_0000109 a rdfs:Class ;
rdfs:label "measurement datum"@en ;
rdfs:comment "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device."@en ;
rdfs:subClassOf obo:IAO_0000027 .
a rdfs:Class ;
rdfs:label "storing state" ;
rdfs:comment "Storing is containing or collecting flows to accumulate. [NIST]" ;
rdfs:subClassOf .
obo:CHEBI_134179 a rdfs:Class ;
rdfs:label "volatile organic compound" ;
rdfs:comment "Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa." ;
rdfs:subClassOf obo:CHEBI_72695 .
obo:PROCO_0000269 a rdfs:Class ;
rdfs:label "Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients" ;
rdfs:comment "An ICH Guideline for the manufacture of APIs for use in human drug (medicinal) products." ;
rdfs:subClassOf obo:PROCO_0000136 .
obo:CHEBI_76759 a rdfs:Class ;
rdfs:label "EC 3.* (hydrolase) inhibitor" ;
rdfs:comment "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." ;
rdfs:subClassOf obo:CHEBI_23924 .
obo:PROCO_0000177 a rdfs:Class ;
rdfs:label "Widmer column"@en ;
rdfs:comment "A fractionating column consisting of four concentric glass tubes and a central glass rod, with a thinner glass rod coiled around it to increase the surface area." ;
rdfs:subClassOf obo:PROCO_0000174 .
obo:PROCO_0000281 a rdfs:Class ;
rdfs:label "laboratory notebook experiment identifier" ;
rdfs:comment "A centrally registered identifier assigned to a laboratory notebook experiment" ;
rdfs:subClassOf obo:IAO_0000314 , obo:IAO_0000578 .
obo:OBI_0000339 a rdfs:Class ;
rdfs:label "planning"@en ;
rdfs:comment "a process of creating or modifying a plan specification"@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:PROCO_0000112 a rdfs:Class ;
rdfs:label "polar point symmetry"@en ;
rdfs:comment "a point symmetry that contains a polar axis."@en ;
rdfs:subClassOf obo:PROCO_0000111 .
obo:PROCO_0000249 a rdfs:Class ;
rdfs:label "tetragonal-trapezohedral" ;
rdfs:comment "6-, 8-, 12-, or 24-trapezium faced closed tetragonal form with enantiomorphic point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
a rdfs:Class ;
rdfs:label "half-life of an exponential decay" ;
rdfs:comment "Time taken by a quantity decreasing according to a mono-exponential decay to be divided by two. Sometimes called t1/2." ;
rdfs:subClassOf .
obo:CHMO_0002773 a rdfs:Class ;
rdfs:label "dissolving" ;
rdfs:comment "A mixing step where a soluble component is mixed with a liquid component." ;
rdfs:subClassOf obo:CHMO_0001685 .
obo:PROCO_0000202 a rdfs:Class ;
rdfs:label "preferred IUPAC name"@en ;
rdfs:comment "A unique name, assigned to a chemical substance and preferred among the possible names generated by IUPAC nomenclature. The \"preferred IUPAC nomenclature\" provides a set of rules for choosing between multiple possibilities in situations where it is important to decide on a unique name. It is intended for use in legal and regulatory situations." ;
rdfs:subClassOf obo:IAO_0000590 .
obo:CHEBI_38976 a rdfs:Class ;
rdfs:label "alkylbenzene" ;
rdfs:comment "A monocyclic arene that is benzene substituted with one or more alkyl groups." ;
rdfs:subClassOf obo:CHEBI_22712 , obo:CHEBI_33847 .
obo:CHEBI_76969 a rdfs:Class ;
rdfs:label "bacterial metabolite" ;
rdfs:comment "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." ;
rdfs:subClassOf obo:CHEBI_75787 .
obo:CHEBI_36829 a rdfs:Class ;
rdfs:label "polyatomic monoanion" ;
rdfs:subClassOf obo:CHEBI_33273 , obo:CHEBI_36830 .
obo:PROCO_0000062 a rdfs:Class ;
rdfs:label "kinetic order" ;
rdfs:comment "A constant representing the concentration driving force" ;
rdfs:subClassOf .
obo:CHEBI_24834 a rdfs:Class ;
rdfs:label "inorganic anion" ;
rdfs:subClassOf obo:CHEBI_22563 , obo:CHEBI_36914 .
obo:IAO_0000102 a rdfs:Class ;
rdfs:label "data about an ontology part"@en ;
rdfs:comment "Data about an ontology part is a data item about a part of an ontology, for example a term"@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:CHEBI_29340 a rdfs:Class ;
rdfs:label "hydridonitrate(2-)" ;
rdfs:comment "A divalent inorganic anion resulting from the removal of two protons from ammonia." ;
rdfs:subClassOf obo:CHEBI_35106 , obo:CHEBI_79388 .
a rdfs:Class ;
rdfs:label "starting material role" ;
rdfs:comment "A role for a material used in the synthesis of a new drug substance that is incorporated as an element into the structure of an intermediate and/or of the new drug substance. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:PROCO_0000214 a rdfs:Class ;
rdfs:label "synthesis flow chart"@en ;
rdfs:comment "A 2-D representation of a step-by-step progression through a synthesis or part of a synthesis showing reagents, intermediates and reaction conditions." ;
rdfs:subClassOf .
obo:CHEBI_39142 a rdfs:Class ;
rdfs:label "Bronsted base" ;
rdfs:comment "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." ;
rdfs:subClassOf obo:CHEBI_15339 , obo:CHEBI_22695 .
obo:CHMO_0001600 a rdfs:Class ;
rdfs:label "liquid–liquid extraction" ;
rdfs:comment "The process of transferring a dissolved substance from one liquid phase to another (immiscible or partially miscible) liquid phase in contact with it." ;
rdfs:subClassOf obo:CHMO_0001598 .
a rdfs:Class ;
rdfs:label "drying additive role" ;
rdfs:comment "A drying additive role is the role of a material in a drying process that supports the drying process. [Allotrope]" ;
rdfs:subClassOf , .
obo:CHMO_0002198 a rdfs:Class ;
rdfs:label "recrystallisation" ;
rdfs:comment "A technique for purifying a crystalline sample where the impure sample is dissolved in a small volume of solvent, forming a supersaturated solution. As the temperature of the solution drops, pure crystals form, the impurities remaining dissolved in the solvent." ;
rdfs:subClassOf obo:CHMO_0001477 .
obo:PROCO_0000130 a rdfs:Class ;
rdfs:label "unit cell beta internal angle"@en ;
rdfs:comment "A unit cell quality describing the angle between the a and c axes." ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:PROCO_0000293 a rdfs:Class ;
rdfs:label "calculation" ;
rdfs:comment "A planned process that converts input data into output data based on some equation or set of equations" ;
rdfs:subClassOf obo:OBI_0000011 .
a rdf:Property ;
rdfs:range .
a rdfs:Class ;
rdfs:label "transferring device" ;
rdfs:comment "A transferring device is a device that is designed to transfer material. [Allotrope]" ;
rdfs:subClassOf .
obo:PROCO_0000113 a rdfs:Class ;
rdfs:label "centrosymmetric point symmetry"@en ;
rdfs:comment "a point symmetry in which the original structure can be obtained by reflecting all lattice points through a single point."@en ;
rdfs:subClassOf obo:PROCO_0000111 .
obo:CHMO_0001697 a rdfs:Class ;
rdfs:label "reprecipitation" ;
rdfs:comment "The planned repetition of a precipitation to remove impurities from a precipitate or improve its stoichiometry." ;
rdfs:subClassOf obo:CHMO_0001688 .
obo:PROCO_0000141 a rdfs:Class ;
rdfs:label "solid solution"@en ;
rdfs:comment "A solid in solid solution is a solution where the continuous phase is a solid and the dispersed phase is a solid. [Allotrope]" ;
rdfs:subClassOf obo:CHMO_0000993 .
obo:CHMO_0001537 a rdfs:Class ;
rdfs:label "reactive distillation" ;
rdfs:comment "A method of separating a lower-boiling-point product from its reactants in a reaction mixture. The product is vaporised by the application of heat and then cooled by the action of cold water in a condenser." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:PROCO_0000101 a rdfs:Class ;
rdfs:label "pressure measurement"@en ;
rdfs:comment "A process measurement of the pressure in a process" ;
rdfs:subClassOf obo:PROCO_0000100 .
obo:CHEBI_35197 a rdfs:Class ;
rdfs:label "lumiphore" ;
rdfs:comment "A part of a molecular entity (atom or group of atoms) in which electronic excitation associated with a given emission band is approximately localized." ;
rdfs:subClassOf obo:CHEBI_52215 .
obo:CHMO_0001552 a rdfs:Class ;
rdfs:label "drum drying" ;
rdfs:comment "The removal of solvent from a sample by applying it as a thin layer to the surface of a heated drum." ;
rdfs:subClassOf obo:CHMO_0001549 .
obo:CHEBI_25741 a rdfs:Class ;
rdfs:label "oxide" ;
rdfs:comment "An oxide is a chemical compound of oxygen with other chemical elements." ;
rdfs:subClassOf obo:CHEBI_25806 , obo:CHEBI_37577 .
obo:CHMO_0001554 a rdfs:Class ;
rdfs:label "oven drying" ;
rdfs:comment "The removal of solvent from a sample by heating in an oven." ;
rdfs:subClassOf obo:CHMO_0001549 .
obo:PROCO_0000119 a rdfs:Class ;
rdfs:label "unit cell c-axis length"@en ;
rdfs:comment "the length of the c-axis of a unit cell"@en ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:CHEBI_33247 a rdfs:Class ;
rdfs:label "organic group" ;
rdfs:comment "Any substituent group or skeleton containing carbon." ;
rdfs:subClassOf obo:CHEBI_24433 .
obo:CHEBI_25355 a rdfs:Class ;
rdfs:label "mitochondrial respiratory-chain inhibitor" ;
rdfs:subClassOf obo:CHEBI_38497 .
obo:CHEBI_38632 a rdfs:Class ;
rdfs:label "membrane transport modulator" ;
rdfs:comment "Any agent that affects the transport of molecular entities across a biological membrane." ;
rdfs:subClassOf obo:CHEBI_52208 .
a rdfs:Class ;
rdfs:label "to increment" ;
rdfs:comment "To enlarge a flow in a predetermined and fixed manner. [NIST]" ;
rdfs:subClassOf .
obo:CHMO_0001642 a rdfs:Class ;
rdfs:label "nano-filtration" ;
rdfs:comment "A pressure-driven membrane-based separation process in which particles and dissolved macromolecules larger 200 Da are rejected." ;
rdfs:subClassOf obo:CHMO_0001640 .
obo:PROCO_0000011 a rdfs:Class ;
rdfs:label "reaction process profile" ;
rdfs:comment "A process profile that tracks some aspect of a reaction." ;
rdfs:subClassOf obo:BFO_0000144 .
obo:CHEBI_166831 a rdfs:Class ;
rdfs:label "copper chelator" ;
rdfs:comment "A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points." ;
rdfs:subClassOf obo:CHEBI_38161 .
obo:PROCO_0000084 a rdfs:Class ;
rdfs:label "route selection"@en ;
rdfs:comment "A process that ends with a milestone where a selection will be made on route process." ;
rdfs:subClassOf obo:PROCO_0000099 .
obo:RO_0002230 a rdf:Property ;
rdfs:range .
a rdfs:Class ;
rdfs:label "catalyst role" ;
rdfs:comment "A catalyst role is a reagent role of a substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction; the process is called catalysis. The catalyst is both a reactant and product of the reaction. [IUPAC]" ;
rdfs:subClassOf obo:OBI_0000086 .
obo:CHEBI_22563 a rdfs:Class ;
rdfs:label "anion" ;
rdfs:comment "A monoatomic or polyatomic species having one or more elementary charges of the electron." ;
rdfs:subClassOf obo:CHEBI_24870 .
obo:CHMO_0002158 a rdfs:Class ;
rdfs:label "Czochralski process" ;
rdfs:comment "A method of producing large single crystals (of semiconductors or metals) by inserting a small seed crystal into a crucible filled with similar molten material, then slowly pulling the seed up from the melt while rotating it." ;
rdfs:subClassOf obo:CHMO_0002224 .
obo:CHEBI_167095 a rdfs:Class ;
rdfs:label "secondary fatty alcohol" ;
rdfs:comment "A fatty alcohol consisting of a chain of 3 to greater than 27 carbon atoms in which a hydroxy group is attached to a saturated carbon atom different from the terminal carbons. Secondary fatty alcohols may be saturated or unsaturated and may be branched or unbranched." ;
rdfs:subClassOf obo:CHEBI_24026 .
obo:CHEBI_33661 a rdfs:Class ;
rdfs:label "monocyclic compound" ;
rdfs:subClassOf obo:CHEBI_33595 .
obo:PROCO_0000270 a rdfs:Class ;
rdfs:label "residual solvent impurity" ;
rdfs:comment "Residual solvents in pharmaceuticals are defined here as organic volatile chemicals that are used or produced in the manufacture of drug substances or excipients, or in the preparation of drug products. The solvents are not completely removed by practical manufacturing techniques." ;
rdfs:subClassOf .
obo:CHEBI_33246 a rdfs:Class ;
rdfs:label "inorganic group" ;
rdfs:comment "Any substituent group which does not contain carbon." ;
rdfs:subClassOf obo:CHEBI_24433 .
obo:CHEBI_24869 a rdfs:Class ;
rdfs:label "ionophore" ;
rdfs:comment "A compound which can carry specific ions through membranes of cells or organelles." ;
rdfs:subClassOf obo:CHEBI_38632 .
obo:CHEBI_46629 a rdfs:Class ;
rdfs:label "oxo group" ;
rdfs:subClassOf obo:CHEBI_33246 .
obo:CHEBI_76932 a rdfs:Class ;
rdfs:label "pathway inhibitor" ;
rdfs:comment "An enzyme inhibitor that interferes with one or more steps in a metabolic pathway." ;
rdfs:subClassOf obo:CHEBI_23924 .
obo:PROCO_0000124 a rdfs:Class ;
rdfs:label "orthorhombic unit cell"@en ;
rdfs:comment "A unit cell that has three perpendicular axes, all of different lengths" ;
rdfs:subClassOf obo:PROCO_0000120 .
obo:CHMO_0001636 a rdfs:Class ;
rdfs:label "foam fractionation" ;
rdfs:comment "A method of separation in which a component of the bulk liquid is preferentially adsorbed at the liquid–vapour interface and is removed by foaming." ;
rdfs:subClassOf obo:CHMO_0001625 .
obo:CHEBI_38828 a rdfs:Class ;
rdfs:label "nonionic surfactant" ;
rdfs:comment "A surfactant with an uncharged hydrophilic headgroup." ;
rdfs:subClassOf obo:CHEBI_35195 .
obo:PATO_0000001 a rdfs:Class ;
rdfs:label "quality" ;
rdfs:comment "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" ;
rdfs:subClassOf obo:BFO_0000019 .
obo:CHEBI_36962 a rdfs:Class ;
rdfs:label "organochalcogen compound" ;
rdfs:comment "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." ;
rdfs:subClassOf obo:CHEBI_33285 , obo:CHEBI_33304 .
obo:CHEBI_33836 a rdfs:Class ;
rdfs:label "benzenoid aromatic compound" ;
rdfs:subClassOf obo:CHEBI_33598 , obo:CHEBI_33659 .
obo:CHMO_0001625 a rdfs:Class ;
rdfs:label "fractionation" ;
rdfs:comment "The process of dividing up a sample mixture into smaller quantities according to their physical (e.g. size, solubility) or chemical (e.g. bonding, reactivity) properties." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:CHMO_0002770 a rdfs:Class ;
rdfs:label "sample heating" ;
rdfs:comment "A sample preparation step involving the increase in temperature of a sample." ;
rdfs:subClassOf obo:OBI_0000094 .
obo:CHEBI_25555 a rdfs:Class ;
rdfs:label "nitrogen atom" ;
rdfs:subClassOf obo:CHEBI_25585 , obo:CHEBI_33300 .
obo:PROCO_0000154 a rdfs:Class ;
rdfs:label "pinacoidal"@en ;
rdfs:comment "2-faced triclinic form with centrosymmetric point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000225 a rdfs:Class ;
rdfs:label "rate equation" ;
rdfs:comment "An equation that links the initial or forward reaction rate with the molar concentrations or pressures of the reactants and constant parameters (normally rate coefficients and partial reaction orders)." ;
rdfs:subClassOf obo:PROCO_0000006 .
obo:CHMO_0002523 a rdfs:Class ;
rdfs:label "vapour-phase extraction" ;
rdfs:comment "The process of transferring a substance from a vapour to a solid phase by passing the vapour sample through a stationary phase (e.g. silica particles) and then desorbing it using a desorbent or carrier gas." ;
rdfs:subClassOf obo:CHMO_0001577 .
obo:IAO_0000032 a rdfs:Class ;
rdfs:label "scalar measurement datum"@en ;
rdfs:comment "A scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label."@en ;
rdfs:subClassOf obo:IAO_0000109 .
obo:CHEBI_35681 a rdfs:Class ;
rdfs:label "secondary alcohol" ;
rdfs:comment "A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it." ;
rdfs:subClassOf obo:CHEBI_30879 .
obo:PROCO_0000145 a rdfs:Class ;
rdfs:label "hydrate"@en ;
rdfs:comment "A hydrate is a solvate that has water as the solvent adduct." ;
rdfs:subClassOf obo:PROCO_0000144 .
obo:CHEBI_36916 a rdfs:Class ;
rdfs:label "cation" ;
rdfs:comment "A monoatomic or polyatomic species having one or more elementary charges of the proton." ;
rdfs:subClassOf obo:CHEBI_24870 .
obo:CHEBI_17578 a rdfs:Class ;
rdfs:label "toluene" ;
rdfs:comment "The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_27024 , obo:CHEBI_38975 .
obo:PROCO_0000134 a rdfs:Class ;
rdfs:label "unit cell Z' value"@en ;
rdfs:comment "A unit cell quality indicating the number of asymmetric units in the unit cell. It is equal to the Z value divided by the lowest Wycoff position multiplicity" ;
rdfs:subClassOf obo:PROCO_0000109 .
obo:CHEBI_33659 a rdfs:Class ;
rdfs:label "organic aromatic compound" ;
rdfs:subClassOf obo:CHEBI_33655 , obo:CHEBI_33832 .
obo:CHEBI_33847 a rdfs:Class ;
rdfs:label "monocyclic arene" ;
rdfs:comment "A monocyclic aromatic hydrocarbon." ;
rdfs:subClassOf obo:CHEBI_33658 .
obo:OBI_0000406 a rdfs:Class ;
rdfs:label "PCR product"@en ;
rdfs:comment "is double stranded DNA that is the specified output of a polymerase chain reaction"@en ;
rdfs:subClassOf obo:CHEBI_4705 , obo:OBI_0000809 .
obo:PROCO_0000267 a rdfs:Class ;
rdfs:label "ICH Q3D Guidance for Elemental Impurities" ;
rdfs:comment "An ICH guideline for the control of elemental impurities in new drug products (medicinal products), establishing Permitted Daily Exposures (PDEs) for 24 Elemental Impurities (EIs) for drug products administered by the oral, parenteral and inhalation routes of administration." ;
rdfs:subClassOf obo:PROCO_0000136 .
obo:CHEBI_33582 a rdfs:Class ;
rdfs:label "carbon group molecular entity" ;
rdfs:subClassOf obo:CHEBI_33675 .
obo:CHMO_0001478 a rdfs:Class ;
rdfs:label "cocrystallisation" ;
rdfs:comment "The simultaneous crystallisation of two different substances or two different structural elements of the same substance." ;
rdfs:subClassOf obo:CHMO_0001477 .
obo:CHMO_0001688 a rdfs:Class ;
rdfs:label "precipitation" ;
rdfs:comment "The sedimentation of a solid material (a 'precipitate') from a liquid solution in which the material is present in amounts greater than its solubility in the liquid." ;
rdfs:subClassOf obo:CHMO_0002916 .
obo:PROCO_0000196 a rdfs:Class ;
rdfs:label "laboratory notebook"@en ;
rdfs:comment "A document that is a primary record of research used to document their hypotheses, experiments and initial analysis or interpretation of these experiments serving as an organizational tool, a memory aid, and can also have a role in protecting any intellectual property that comes from the research." ;
rdfs:subClassOf obo:IAO_0000310 .
obo:CHEBI_15734 a rdfs:Class ;
rdfs:label "primary alcohol" ;
rdfs:comment "A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." ;
rdfs:subClassOf obo:CHEBI_30879 .
obo:CHEBI_29337 a rdfs:Class ;
rdfs:label "azanide" ;
rdfs:subClassOf obo:CHEBI_35106 , obo:CHEBI_79389 .
obo:CHMO_0001598 a rdfs:Class ;
rdfs:label "solvent extraction" ;
rdfs:comment "The process of transferring a substance from any matrix to an appropriate liquid phase." ;
rdfs:subClassOf obo:CHMO_0001577 .
obo:CHMO_0001653 a rdfs:Class ;
rdfs:label "liquid-assisted grinding" ;
rdfs:comment "The mechanical reduction of the particle size of a solid sample by attribution (friction), impact or cutting in the presence of a small amount of solvent." ;
rdfs:subClassOf obo:CHMO_0001652 .
a rdfs:Class ;
rdfs:label "support role" ;
rdfs:comment "A support role is a type of role whose bearer participates in a process in order to support the process so that it proceeds towards a secondary objective. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PROCO_0000285 a rdfs:Class ;
rdfs:label "solubility screening design" ;
rdfs:comment "A screening design to determine to solubility of a compound" ;
rdfs:subClassOf obo:PROCO_0000091 .
obo:CHEBI_24870 a rdfs:Class ;
rdfs:label "ion" ;
rdfs:comment "A molecular entity having a net electric charge." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:PROCO_0000250 a rdfs:Class ;
rdfs:label "ditetragonal-pyramidal" ;
rdfs:comment "8-faced tetragonal form with polar point and enantiomorphic point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000180 a rdfs:Class ;
rdfs:label "Allihn condenser"@en ;
rdfs:comment "A condensor consisting of a jacketed long glass tube with a series of bulbs on the tube to increase the surface area upon which the vapor constituents may condense." ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:CHMO_0001593 a rdfs:Class ;
rdfs:label "membrane extraction" ;
rdfs:comment "The transfer of a solute from one phase (the 'donor' or 'feed' phase) to another (the 'acceptor' or 'strip' phase) across a nonporous membrane." ;
rdfs:subClassOf obo:CHMO_0001577 .
a rdfs:Class ;
rdfs:label "identified impurity role" ;
rdfs:comment "An impurity for which a structural characterization has been achieved. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:CHEBI_48358 a rdfs:Class ;
rdfs:label "polar aprotic solvent" ;
rdfs:comment "A solvent with a comparatively high relative permittivity (or dielectric constant), greater than ca. 15, and a sizable permanent dipole moment, that cannot donate suitably labile hydrogen atoms to form strong hydrogen bonds." ;
rdfs:subClassOf obo:CHEBI_48354 , obo:CHEBI_48357 .
obo:CHMO_0001686 a rdfs:Class ;
rdfs:label "Ostwald ripening" ;
rdfs:comment "The growth of larger crystals from those of smaller size, which have a higher solubility than the larger ones." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:PROCO_0000092 a rdfs:Class ;
rdfs:label "batch campaign"@en ;
rdfs:comment "A planned process of manufacturing one or more batches of a product in unbroken succession. It includes equipment turnover and cleaning can include dry-runs before committing the starting materials." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:OBI_0000656 a rdfs:Class ;
rdfs:label "data set of predicted values according to fitted curve"@en ;
rdfs:comment "A data set which is the output of a curve fitting data transformation in which the aim is to find a curve which matches a series of data points and possibly other constraints."@en ;
rdfs:subClassOf obo:IAO_0000100 .
obo:PROCO_0000005 a rdfs:Class ;
rdfs:label "factor"@en ;
rdfs:comment "A data item that is a member of a minimal set of independent variables that can be used to model the dependent reponses in a set of related experiments." ;
rdfs:subClassOf obo:IAO_0000027 .
obo:CHEBI_76648 a rdfs:Class ;
rdfs:label "fluorescence quencher" ;
rdfs:comment "A compound used to return an excited fluorophore to the ground state by transfer of energy from fluorophore to quencher without the emission of light, with the quencher being promoted to its own excited state." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_33709 a rdfs:Class ;
rdfs:label "amino acid" ;
rdfs:comment "A carboxylic acid containing one or more amino groups." ;
rdfs:subClassOf obo:CHEBI_33575 , obo:CHEBI_50047 .
obo:CHEBI_38497 a rdfs:Class ;
rdfs:label "respiratory-chain inhibitor" ;
rdfs:subClassOf obo:CHEBI_38496 .
obo:PROCO_0000198 a rdfs:Class ;
rdfs:label "international nonproprietary name"@en ;
rdfs:comment "A centrally registered identifier given to a pharmaceutical drug or an active ingredient coordinated by the World Health Organization (WHO) that is unique generic and non-proprietary." ;
rdfs:subClassOf obo:IAO_0000578 , obo:IAO_0000590 .
obo:PROCO_0000079 a rdfs:Class ;
rdfs:label "chemical process development"@en ;
rdfs:comment "A planned process with data output of commercial synthetic chemical route." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHEBI_62803 a rdfs:Class ;
rdfs:label "fuel additive" ;
rdfs:comment "Any additive that enhances the efficiency of fuel." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHEBI_16991 a rdfs:Class ;
rdfs:label "deoxyribonucleic acid" ;
rdfs:comment "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." ;
rdfs:subClassOf obo:CHEBI_33696 .
obo:PROCO_0000277 a rdfs:Class ;
rdfs:label "explosion" ;
rdfs:comment "A process during which a material entity undergoes a rapid increase in volume, releasing gasses and various forms of energy, often including thermal, light and sound energy." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:PROCO_0000256 a rdfs:Class ;
rdfs:label "ditrigonal-pyramidal" ;
rdfs:comment "6-faced trigonal form where all faces are related by a 3-fold rotational axis with polar point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000288 a rdfs:Class ;
rdfs:label "waste stream" ;
rdfs:comment "A portion of material with a debris role that is a material output of a process." ;
rdfs:subClassOf obo:CHMO_0000993 .
obo:PROCO_0000242 a rdfs:Class ;
rdfs:label "rhombic-pyramidal" ;
rdfs:comment "3, 4, 6, 8, or 12 nonparallel faced orthorhombic system with polar point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:PROCO_0000299 a rdfs:Class ;
rdfs:label "critical process parameter" ;
rdfs:comment "A process profile whose variability has an impact on a critical quality attribute and therefore should be monitored or controlled to ensure the process produces the desired quality." ;
rdfs:subClassOf obo:BFO_0000144 .
obo:OBI_0600058 a rdfs:Class ;
rdfs:label "enzymatic amplification"@en ;
rdfs:comment "the use of enzymes to increase the number of molecules of a biomaterial"@en ;
rdfs:subClassOf obo:OBI_0000094 .
obo:PROCO_0000274 a rdfs:Class ;
rdfs:label "Permitted Daily Exposure" ;
rdfs:comment "The maximum acceptable intake per day of residual solvent in pharmaceutical products" ;
rdfs:subClassOf obo:IAO_0000005 .
obo:PATO_0000125 a rdfs:Class ;
rdfs:label "mass" ;
rdfs:comment "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." ;
rdfs:subClassOf obo:PATO_0000001 .
obo:CHMO_0001574 a rdfs:Class ;
rdfs:label "evaporation" ;
rdfs:comment "The physical process by which a liquid substance is converted to a gas or vapour. This may occur at or below the normal boiling point of the liquid (the temperature at which a liquid boils at 1 atmosphere pressure) and the process is endothermic." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:CHEBI_30879 a rdfs:Class ;
rdfs:label "alcohol" ;
rdfs:comment "A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." ;
rdfs:subClassOf obo:CHEBI_33822 .
obo:CHEBI_33579 a rdfs:Class ;
rdfs:label "main group molecular entity" ;
rdfs:comment "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:IAO_0000300 a rdfs:Class ;
rdfs:label "textual entity"@en ;
rdfs:comment "A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHEBI_52216 a rdfs:Class ;
rdfs:label "photobiochemical role" ;
rdfs:comment "A role played by a molecular entity or part thereof in a photobiochemical process." ;
rdfs:subClassOf obo:CHEBI_52206 , obo:CHEBI_52215 .
obo:BFO_0000003 a rdfs:Class ;
rdfs:label "occurrent"@en ;
rdfs:comment "An entity that has temporal parts and that happens, unfolds or develops through time."@en ;
rdfs:subClassOf obo:BFO_0000001 .
obo:CHEBI_33250 a rdfs:Class ;
rdfs:label "atom" ;
rdfs:comment "A chemical entity constituting the smallest component of an element having the chemical properties of the element." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:PROCO_0000261 a rdfs:Class ;
rdfs:label "hexagonal-trapezohedral" ;
rdfs:comment "6-faced closed hexagonal form with enantiomorphic point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_52090 a rdfs:Class ;
rdfs:label "methoxide" ;
rdfs:comment "An organic anion that is the conjugate base of methanol." ;
rdfs:subClassOf obo:CHEBI_25696 .
obo:PROCO_0000231 a rdfs:Class ;
rdfs:label "concentration profile" ;
rdfs:comment "A quality process profile that tracks the concentration changes of a species" ;
rdfs:subClassOf obo:PROCO_0000047 .
obo:PROCO_0000158 a rdfs:Class ;
rdfs:label "gyroidal"@en ;
rdfs:comment "A cubic form with no mirror planes and enantiomorphic point symmetry" ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_52209 a rdfs:Class ;
rdfs:label "aetiopathogenetic role" ;
rdfs:comment "A role played by the molecular entity or part thereof which causes the development of a pathological process." ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:IAO_0000590 a rdfs:Class ;
rdfs:label "written name"@en ;
rdfs:comment "A textual entity that denotes a particular in reality."@en ;
rdfs:subClassOf obo:IAO_0000300 .
obo:CHMO_0001604 a rdfs:Class ;
rdfs:label "pressurised-fluid extraction" ;
rdfs:comment "The process of transferring a dissolved substance from one liquid phase to another (immiscible or partially miscible) liquid phase in contact with it using solvents at elevated temperature (50–200 °C) and pressure (7–20 MPa)." ;
rdfs:subClassOf obo:CHMO_0001600 .
obo:CHMO_0001541 a rdfs:Class ;
rdfs:label "air-sensitive vacuum distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a high-boiling-point sample mixture are vaporised by the application of heat at low pressure and then cooled by the action of cold water in a condenser. The vacuum is replaced by an inert gas once the distillation is complete." ;
rdfs:subClassOf obo:CHMO_0001540 .
obo:PROCO_0000174 a rdfs:Class ;
rdfs:label "fractionating column"@en ;
rdfs:comment "A device to separate vaporized mixtures of liquid compounds with close volatility." ;
rdfs:subClassOf .
obo:CHEBI_23004 a rdfs:Class ;
rdfs:label "carbamoyl group" ;
rdfs:comment "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." ;
rdfs:subClassOf obo:CHEBI_27207 .
obo:CHMO_0001000 a rdfs:Class ;
rdfs:label "chromatography" ;
rdfs:comment "A separation method where the components are distributed between two phases, one of which is stationary, while the other moves in a definite direction." ;
rdfs:subClassOf obo:CHMO_0000999 .
obo:PROCO_0000176 a rdfs:Class ;
rdfs:label "Snyder column"@en ;
rdfs:comment "A fractionating column divided into sections (usually 3 to 6) by horizontal glass partitions or constrictions each of which seats a hollow glass bead with an inverted \"teardrop\" shape acting as check valves, closing and opening with vapor flow, and enhancing vapor-condensate mixing." ;
rdfs:subClassOf obo:PROCO_0000174 .
obo:PROCO_0000016 a rdfs:Class ;
rdfs:label "critical process parameter specification"@en ;
rdfs:comment "A process profile specification that is associated with a critical process parameter (CPP). Critical process parameters (CPPs) in pharmaceutical manufacturing are key variables affecting the production process." ;
rdfs:subClassOf obo:PROCO_0000015 .
a rdfs:Class ;
rdfs:label "filtration role" ;
rdfs:comment "A filtration role is a role of a material in a filtration process. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PROCO_0000187 a rdfs:Class ;
rdfs:label "bulk substance quality"@en ;
rdfs:comment "A quality associated with a portion of material" ;
rdfs:subClassOf obo:BFO_0000019 .
obo:CHEBI_52211 a rdfs:Class ;
rdfs:label "physiological role" ;
rdfs:subClassOf obo:CHEBI_24432 .
a rdfs:Class ;
rdfs:label "by-product role" ;
rdfs:comment "A material role of an expected but not desired product of a synthesis. [Allotrope]" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "providing state" ;
rdfs:comment "Providing is the state of accumulating or supplying a material or energy flow. [NIST]" ;
rdfs:subClassOf .
obo:CHEBI_33697 a rdfs:Class ;
rdfs:label "ribonucleic acid" ;
rdfs:comment "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." ;
rdfs:subClassOf obo:CHEBI_33696 .
obo:PROCO_0000152 a rdfs:Class ;
rdfs:label "point group symmetry"@en ;
rdfs:comment "A group of geometric symmetries (isometries) that keep at least one point fixed." ;
rdfs:subClassOf obo:PATO_0000965 .
obo:PROCO_0000184 a rdfs:Class ;
rdfs:label "Dimroth condenser"@en ;
rdfs:comment "A condensor with an internal double spiral through which coolant flows such that the coolant inlet and outlet are both at the top" ;
rdfs:subClassOf obo:PROCO_0000178 .
obo:PROCO_0000192 a rdfs:Class ;
rdfs:label "volumetric flask"@en ;
rdfs:comment "A flask for preparing liquids with volumes of high precision. It is a flask with an approximately pear-shaped body and a long neck with a circumferential fill line." ;
rdfs:subClassOf obo:PROCO_0000191 .
obo:CHEBI_80291 a rdfs:Class ;
rdfs:label "aliphatic nitrile" ;
rdfs:comment "Any nitrile derived from an aliphatic compound." ;
rdfs:subClassOf obo:CHEBI_18379 .
obo:PROCO_0000268 a rdfs:Class ;
rdfs:label "ICH Q6A Specifications: Test Procedures and Acceptance Criteria for Chemical Substances" ;
rdfs:comment "An ICH guidance on the setting and justification of acceptance criteria and the selection of test procedures for new drug substances of synthetic chemical origin, and new drug products produced from them, which have not been registered previously in the ICH regions." ;
rdfs:subClassOf obo:PROCO_0000136 .
obo:CHEBI_48578 a rdfs:Class ;
rdfs:label "radical scavenger" ;
rdfs:comment "A role played by a substance that can react readily with, and thereby eliminate, radicals." ;
rdfs:subClassOf obo:CHEBI_22586 .
obo:CHEBI_35366 a rdfs:Class ;
rdfs:label "fatty acid" ;
rdfs:comment "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax." ;
rdfs:subClassOf obo:CHEBI_18059 , obo:CHEBI_25384 .
obo:PROCO_0000203 a rdfs:Class ;
rdfs:label "chemical abstracts name"@en ;
rdfs:comment "The name assigned to a chemical substance by the Chemical Abstracts Service of the American Chemical Society" ;
rdfs:subClassOf obo:IAO_0000590 .
obo:CHEBI_63908 a rdfs:Class ;
rdfs:label "film-forming compound" ;
rdfs:comment "Any compound that leaves a pliable, cohesive, and continuous covering over a surface when applied to it." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:CHMO_0002221 a rdfs:Class ;
rdfs:label "Lely method" ;
rdfs:comment "A method for crystal growth where polycrystalline SiC lumps are carefully packed between two concentric graphite tubes. The inner tube is then withdrawn leaving a porous SiC layer inside the outer tube. The outer tube is then heated (~2500 °C) in Ar, causing the SiC powder to sublime and nucleate on a cooler surface." ;
rdfs:subClassOf obo:CHMO_0002224 .
obo:PROCO_0000046 a rdfs:Class ;
rdfs:label "process chemistry filing"@en ;
rdfs:comment "A planned process." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:RO_0002180 a rdf:Property ;
rdfs:range .
obo:OBI_0000456 a rdfs:Class ;
rdfs:label "material transformation objective"@en ;
rdfs:comment "an objective specifiction that creates an specific output object from input materials."@en ;
rdfs:subClassOf obo:IAO_0000005 .
obo:CHEBI_62049 a rdfs:Class ;
rdfs:label "acyl donor" ;
rdfs:comment "Any donor that can transfer acyl groups between molecular entities." ;
rdfs:subClassOf obo:CHEBI_17891 .
obo:PROCO_0000019 a rdfs:Class ;
rdfs:label "CQA specification"@en ;
rdfs:comment "A quality specification set against a critical quality attribute of a material" ;
rdfs:subClassOf obo:PROCO_0000018 .
obo:CHMO_0001643 a rdfs:Class ;
rdfs:label "reverse osmosis" ;
rdfs:comment "A separation process which involves using pressure to force a solution through a membrane, retaining the solute on one side and allowing the pure solvent to pass to the other side. (This is the reverse of the normal osmosis process, which is the natural movement of solvent from an area of low solute concentration, through a membrane, to an area of high solute concentration.)" ;
rdfs:subClassOf obo:CHMO_0001640 .
obo:CHEBI_63247 a rdfs:Class ;
rdfs:label "reducing agent" ;
rdfs:comment "The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:PROCO_0000068 a rdfs:Class ;
rdfs:label "slurry"@en ;
rdfs:comment "A suspension (AFM_0000442) that is a mix of solids in a liquid" ;
rdfs:subClassOf obo:BFO_0000040 .
obo:CHEBI_50312 a rdfs:Class ;
rdfs:label "onium compound" ;
rdfs:subClassOf obo:CHEBI_37577 .
obo:CHEBI_37175 a rdfs:Class ;
rdfs:label "organic hydride" ;
rdfs:subClassOf obo:CHEBI_33692 .
obo:CHEBI_76807 a rdfs:Class ;
rdfs:label "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor" ;
rdfs:comment "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." ;
rdfs:subClassOf obo:CHEBI_76764 .
obo:CHEBI_26911 a rdfs:Class ;
rdfs:label "oxolane" ;
rdfs:comment "A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen." ;
rdfs:subClassOf obo:CHEBI_134179 , obo:CHEBI_26912 , obo:CHEBI_36389 , obo:CHEBI_37407 .
obo:CHEBI_59752 a rdfs:Class ;
rdfs:label "bolaamphiphile" ;
rdfs:comment "A surfactant molecule with hydrophilic groups at both ends of a hydrophobic hydrocarbon chain" ;
rdfs:subClassOf obo:CHEBI_35195 .
obo:CHEBI_38157 a rdfs:Class ;
rdfs:label "iron chelator" ;
rdfs:subClassOf obo:CHEBI_38161 .
obo:PROCO_0000246 a rdfs:Class ;
rdfs:label "tetragonal-pyramidal" ;
rdfs:comment "4-faced tetragonal form with polar point and enantiomorphic point symmetry." ;
rdfs:subClassOf obo:PROCO_0000152 .
obo:CHEBI_4705 a rdfs:Class ;
rdfs:label "double-stranded DNA" ;
rdfs:subClassOf obo:CHEBI_16991 .
obo:PROCO_0000235 a rdfs:Class ;
rdfs:label "method of initial rates" ;
rdfs:comment "A series of experiments whereby the initial concentration of each reactant is varied while the other reactant concentrations are kept constant, allowing the determination of the rate order of the reactant." ;
rdfs:subClassOf obo:PROCO_0000234 .
a rdfs:Class ;
rdfs:label "to contain" ;
rdfs:comment "To keep a flow within limits. [NIST]" ;
rdfs:subClassOf .
obo:OBI_0000025 a rdfs:Class ;
rdfs:label "reference substance role"@en ;
rdfs:comment "a role inhering in a material entity that is realized when characteristics or responses elicited by the substance are used for comparison or reference."@en ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PROCO_0000303 a rdfs:Class ;
rdfs:label "pre-exponential factor" ;
rdfs:comment "The pre-exponential factor or A factor is the pre-exponential constant in the Arrhenius equation, an empirical relationship between temperature and rate coefficient. It is usually designated by A when determined from experiment, while Z is usually left for collision frequency." ;
rdfs:subClassOf .
obo:CHEBI_76764 a rdfs:Class ;
rdfs:label "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor" ;
rdfs:comment "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." ;
rdfs:subClassOf obo:CHEBI_76759 .
obo:CHEBI_23888 a rdfs:Class ;
rdfs:label "drug" ;
rdfs:comment "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." ;
rdfs:subClassOf obo:CHEBI_52217 .
obo:CHEBI_37577 a rdfs:Class ;
rdfs:label "heteroatomic molecular entity" ;
rdfs:comment "A molecular entity consisting of two or more chemical elements." ;
rdfs:subClassOf obo:CHEBI_36357 .
obo:CHMO_0001576 a rdfs:Class ;
rdfs:label "rotary evaporation" ;
rdfs:comment "The removal of solvent from a sample by applying heat and lowering the pressure above the sample whilst rotating it at 10–300 rpm." ;
rdfs:subClassOf obo:CHMO_0002208 .
obo:CHMO_0001387 a rdfs:Class ;
rdfs:label "ionothermal synthesis" ;
rdfs:comment "A synthesis method for growing single crystals from an ionic liquid in an autoclave (a thick-walled steel vessel) at high temperature (400 °C) and pressure." ;
rdfs:subClassOf obo:CHMO_0001301 .
obo:PROCO_0000173 a rdfs:Class ;
rdfs:label "crucible"@en ;
rdfs:comment "A crucible is a ceramic or metal container in which metals or other substances may be melted or subjected to very high temperatures. [Wikipedia]" ;
rdfs:subClassOf .
obo:CHEBI_60242 a rdfs:Class ;
rdfs:label "monovalent inorganic cation" ;
rdfs:comment "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." ;
rdfs:subClassOf obo:CHEBI_36915 .
obo:CHEBI_36343 a rdfs:Class ;
rdfs:label "composite particle" ;
rdfs:comment "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." ;
rdfs:subClassOf obo:CHEBI_36342 .
obo:CHMO_0001905 a rdfs:Class ;
rdfs:label "supercritical antisolvent technique" ;
rdfs:comment "A solid sample is dissolved in a common (organic or inorganic) solvent then injected into a supercritical fluid (held under pressure) resulting in a large decrease in solution density. This effect leads to the reduction in solubility of the solid and precipitation." ;
rdfs:subClassOf obo:CHMO_0001904 .
obo:CHEBI_33300 a rdfs:Class ;
rdfs:label "pnictogen" ;
rdfs:comment "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." ;
rdfs:subClassOf obo:CHEBI_33560 .
obo:CHEBI_38162 a rdfs:Class ;
rdfs:label "iron(2+) chelator" ;
rdfs:subClassOf obo:CHEBI_38157 .
obo:CHEBI_22368 a rdfs:Class ;
rdfs:label "alpha-1-microglobulin-Ig alpha complex chromophores" ;
rdfs:subClassOf obo:CHEBI_23240 .
obo:CHEBI_16134 a rdfs:Class ;
rdfs:label "ammonia" ;
rdfs:comment "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." ;
rdfs:subClassOf obo:CHEBI_138675 , obo:CHEBI_35107 , obo:CHEBI_37176 .
obo:CHMO_0001128 a rdfs:Class ;
rdfs:label "adsorption chromatography" ;
rdfs:comment "Chromatography in which separation is based mainly on differences between the adsorption affinities of the sample components for the surface of an active solid." ;
rdfs:subClassOf obo:CHMO_0001000 .
obo:BFO_0000031 a rdfs:Class ;
rdfs:label "generically dependent continuant" ;
rdfs:comment "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en ;
rdfs:subClassOf obo:BFO_0000002 .
obo:OBI_0000067 a rdfs:Class ;
rdfs:label "evaluant role"@en ;
rdfs:comment "a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role"@en ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PROCO_0000169 a rdfs:Class ;
rdfs:label "common technical document"@en ;
rdfs:comment "A set of specifications maintained by the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). for an application dossier for the registration of Medicines and designed to be used across Europe, Japan and the United States." ;
rdfs:subClassOf obo:IAO_0000033 , obo:IAO_0000310 .
obo:PROCO_0000108 a rdfs:Class ;
rdfs:label "assessed solubility purge factor" ;
rdfs:comment "An assessed purge factor based on the solubility of the impurity in the reaction solvent and therefore its propensity to be purged in the mother liquors of steps that involve an isolation of the solid intermediate/product in that step." ;
rdfs:subClassOf obo:PROCO_0000070 .
obo:CHMO_0002020 a rdfs:Class ;
rdfs:label "homogenisation" ;
rdfs:comment "The intensive mixing of μtually insoluble phases (sometimes with addition of surfactants) to obtain a soluble suspension or emulsion." ;
rdfs:subClassOf obo:CHMO_0001685 .
obo:PROCO_0000057 a rdfs:Class ;
rdfs:label "synthetic step specification"@en ;
rdfs:comment "A sequenced set of unit operations for a single synthetic reaction or simultaneous reactions that are executed in a single equipment train." ;
rdfs:subClassOf obo:IAO_0000007 .
obo:IAO_0000579 a rdfs:Class ;
rdfs:label "centrally registered identifier registry"@en ;
rdfs:comment "A CRID registry is a dataset of CRID records, each consisting of a CRID symbol and additional information which was recorded in the dataset through a assigning a centrally registered identifier process."@en ;
rdfs:subClassOf obo:IAO_0000100 .
obo:PROCO_0000282 a rdfs:Class ;
rdfs:label "batch manufacturing record" ;
rdfs:comment "A document that contemporaneously records when, how, by whom each step to produce a specific batch is executed as well as the specific equipment and the specific materials including exact weights and lot numbers." ;
rdfs:subClassOf obo:IAO_0000310 .
obo:IAO_0000005 a rdfs:Class ;
rdfs:label "objective specification" ;
rdfs:comment "A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved."@en ;
rdfs:subClassOf obo:IAO_0000033 .
obo:CHEBI_33832 a rdfs:Class ;
rdfs:label "organic cyclic compound" ;
rdfs:comment "Any organic molecule that consists of atoms connected in the form of a ring." ;
rdfs:subClassOf obo:CHEBI_33595 , obo:CHEBI_72695 .
obo:CHEBI_43176 a rdfs:Class ;
rdfs:label "hydroxy group" ;
rdfs:subClassOf obo:CHEBI_33246 .
obo:CHEBI_35106 a rdfs:Class ;
rdfs:label "nitrogen hydride" ;
rdfs:subClassOf obo:CHEBI_35881 , obo:CHEBI_51143 .
obo:PROCO_0000296 a rdfs:Class ;
rdfs:label "chemometrics" ;
rdfs:comment "A planned process of extracting information from chemical systems by data-driven means." ;
rdfs:subClassOf obo:PROCO_0000159 .
obo:CHMO_0001654 a rdfs:Class ;
rdfs:label "ball milling" ;
rdfs:comment "The mechanical reduction of the particle size of a solid sample by grinding with one or more inert balls (ceramic, flint, or stainless steel, 2–8 mm diameter) rotating around a horizontal axis." ;
rdfs:subClassOf obo:CHMO_0001652 .
a rdfs:Class ;
rdfs:label "unidentified degradation product role" ;
rdfs:comment "A degradation product role for which a structural characterization has not been achieved and that is defined solely by qualitative analytical properties (e.g., chromatographic retention time). [ICH-Q3A]" ;
rdfs:subClassOf , .
obo:CHEBI_51086 a rdfs:Class ;
rdfs:label "chemical role" ;
rdfs:comment "A role played by the molecular entity or part thereof within a chemical context." ;
rdfs:subClassOf obo:BFO_0000023 .
a rdfs:Class ;
rdfs:comment "An unconstrained type or object" .
obo:CHEBI_13941 a rdfs:Class ;
rdfs:label "carbamate" ;
rdfs:subClassOf obo:CHEBI_37022 .
obo:CHMO_0001637 a rdfs:Class ;
rdfs:label "freeze distillation" ;
rdfs:comment "The process of enriching a solution by partially freezing it and removing frozen material that contains less of the dissolved material than the remaining solution." ;
rdfs:subClassOf obo:CHMO_0001625 .
obo:CHEBI_35881 a rdfs:Class ;
rdfs:label "pnictogen hydride" ;
rdfs:subClassOf obo:CHEBI_33242 , obo:CHEBI_33302 .
obo:CHEBI_75772 a rdfs:Class ;
rdfs:label "Saccharomyces cerevisiae metabolite" ;
rdfs:comment "Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." ;
rdfs:subClassOf obo:CHEBI_76946 .
obo:CHEBI_33232 a rdfs:Class ;
rdfs:label "application" ;
rdfs:comment "Intended use of the molecular entity or part thereof by humans." ;
rdfs:subClassOf obo:BFO_0000023 .
a rdfs:Class ;
rdfs:label "solid" ;
rdfs:comment "A state of matter, in which particles are closely packed together. The forces between particles are strong so that the particles cannot move freely but can only vibrate. As a result, a solid has a stable, definite shape, and a definite volume. Solids can only change their shape by force, as when broken or cut. [Wikipedia]" ;
rdfs:subClassOf .
obo:OBI_0200000 a rdfs:Class ;
rdfs:label "data transformation"@en ;
rdfs:comment "A planned process that produces output data from input data."@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHEBI_37527 a rdfs:Class ;
rdfs:label "acid" ;
rdfs:comment "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:PROCO_0000210 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.1.3 General Properties"@en ;
rdfs:comment "The drug substance general properties section of the CTA that includes appearance, thermal behaviour, solubility, chirality /specific rotation, crystallinity / polymorphism, hygroscopicity, solution pH and acid/base diassociation constants." ;
rdfs:subClassOf obo:IAO_0000314 .
obo:PROCO_0000061 a rdfs:Class ;
rdfs:label "mathematical constant" ;
rdfs:comment "A fixed and well-defined number or other non-varying mathematical object." ;
rdfs:subClassOf obo:IAO_0000027 .
obo:BFO_0000144 a rdfs:Class ;
rdfs:label "process profile"@en ;
rdfs:comment "b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])"@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:CHMO_0001533 a rdfs:Class ;
rdfs:label "batch distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. The components in a sample mixture are vaporised by the application of heat and then cooled by the action of cold water in a condenser. Distillation is completed before more sample mixture is added." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:CHEBI_48359 a rdfs:Class ;
rdfs:label "protophilic solvent" ;
rdfs:comment "Solvent that is capable of acting as a hydron (proton) acceptor." ;
rdfs:subClassOf obo:CHEBI_39142 , obo:CHEBI_48354 .
obo:CHMO_0001536 a rdfs:Class ;
rdfs:label "fractional distillation" ;
rdfs:comment "A method of separating mixtures based on differences in their volatilities in a boiling liquid mixture. As the sample mixture to be purified is heated, its vapours rise into a condenser where they are cooled by water. The vapours stick to the inside surface of the condenser where they continue to be heated until they vaporise again." ;
rdfs:subClassOf obo:CHMO_0001532 .
obo:CHEBI_24079 a rdfs:Class ;
rdfs:label "formamides" ;
rdfs:comment "Amides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H)." ;
rdfs:subClassOf obo:CHEBI_37622 .
obo:CHEBI_36338 a rdfs:Class ;
rdfs:label "lepton" ;
rdfs:comment "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." ;
rdfs:subClassOf obo:CHEBI_33233 , obo:CHEBI_36340 .
obo:CHMO_0001596 a rdfs:Class ;
rdfs:label "supported liquid membrane extraction" ;
rdfs:comment "The transfer of a solute from one phase (the 'donor' or 'feed' phase) to another (the 'acceptor' or 'strip' phase) across a non-porous liquid membrane." ;
rdfs:subClassOf obo:CHMO_0001593 .
obo:IAO_0020000 a rdfs:Class ;
rdfs:label "identifier"@en ;
rdfs:comment "An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:CHEBI_23019 a rdfs:Class ;
rdfs:label "carbonyl group" ;
rdfs:subClassOf obo:CHEBI_51422 .
obo:CHEBI_51447 a rdfs:Class ;
rdfs:label "organic univalent group" ;
rdfs:subClassOf obo:CHEBI_33247 .
obo:CHEBI_38500 a rdfs:Class ;
rdfs:label "EC 1.9.3.1 (cytochrome c oxidase) inhibitor" ;
rdfs:comment "An EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor that interferes with the action of cytochrome c oxidase (EC 1.9.3.1)." ;
rdfs:subClassOf obo:CHEBI_25355 , obo:CHEBI_76870 .
obo:PATO_0000965 a rdfs:Class ;
rdfs:label "symmetry" ;
rdfs:comment "A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis." ;
rdfs:subClassOf obo:PATO_0000051 .
obo:PROCO_0000120 a rdfs:Class ;
rdfs:label "unit cell"@en ;
rdfs:comment "The smallest, regularly repeating material portion of a crystalline lattice"@en ;
rdfs:subClassOf obo:CHMO_0000993 .
obo:PROCO_0000080 a rdfs:Class ;
rdfs:label "drug product filing milestone"@en ;
rdfs:comment "A process boundary that represents a milestone of filing the documentation required to obtain regulatory approval to sell a new drug product." ;
rdfs:subClassOf obo:PROCO_0000058 .
obo:PROCO_0000050 a rdfs:Class ;
rdfs:label "filtering"@en ;
rdfs:comment "A unit operation to remove portions of material from a synthesis stream by trapping it on a filter." ;
rdfs:subClassOf obo:PROCO_0000051 .
a rdfs:Class ;
rdfs:label "active pharmaceutical ingredient role" ;
rdfs:comment "The role of a material in a drug product that is biologically active when interacting with other components of the drug product, other potential drug products, or the chemistry of the body into which the drug will be applied. [Allotrope]" ;
rdfs:subClassOf .
obo:OBI_0000409 a rdfs:Class ;
rdfs:label "nucleic acid template role"@en ;
rdfs:comment "a reference substance role which inheres in nucleic acid material entity and is realized in the process of using the nucleic acid bearing the template role as a reference during synthesis of a reverse copy." ;
rdfs:subClassOf obo:OBI_0000025 .
obo:CHEBI_74236 a rdfs:Class ;
rdfs:label "polymerisation monomer" ;
rdfs:comment "Any compound used as a monomer for a polymerisation process. The term is generally used in relation to industrial polymerisation processes." ;
rdfs:subClassOf obo:CHEBI_51086 .
obo:FIX_0000281 a rdfs:Class ;
rdfs:label "redox reaction property" ;
rdfs:subClassOf obo:FIX_0000277 .
a rdfs:Class ;
rdfs:label "to localize" ;
rdfs:comment "To cause a flow (material, energy, signal) to move from one location to another location. [NIST]" ;
rdfs:subClassOf obo:BFO_0000034 .
a rdfs:Class ;
rdfs:label "operand role" ;
rdfs:comment "The role of a participant that is being changed in the process (passive participant) from an input state to an output state. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:IAO_0000310 a rdfs:Class ;
rdfs:label "document"@en ;
rdfs:comment "A collection of information content entities intended to be understood together as a whole"@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PROCO_0000221 a rdfs:Class ;
rdfs:label "CTA Section 3.2.S.3.2 Impurities" ;
rdfs:comment "The document part of the common technical document that provides Information on impurities. Reference ICH guidances Q3A, Q3C, Q5C, Q6A, and Q6B." ;
rdfs:subClassOf obo:IAO_0000314 .
obo:OBI_0000086 a rdfs:Class ;
rdfs:label "reagent role"@en ;
rdfs:comment "A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer. [OBI]" ;
rdfs:subClassOf obo:BFO_0000023 , .
a rdfs:Class ;
rdfs:label "identified degradation product role" ;
rdfs:comment "A degradation product role for which a structural characterization has been achieved. [ICH-Q3A]" ;
rdfs:subClassOf .
obo:CHEBI_33304 a rdfs:Class ;
rdfs:label "chalcogen molecular entity" ;
rdfs:comment "Any p-block molecular entity containing a chalcogen." ;
rdfs:subClassOf obo:CHEBI_33675 .
obo:PROCO_0000008 a rdfs:Class ;
rdfs:label "factorial design"@en ;
rdfs:comment "An experimental design consisting of two or more factors, each with discrete possible values or \"levels\", and whose experimental units take on all or a subset of the possible combinations of these levels across all such factors." ;
rdfs:subClassOf obo:PROCO_0000276 .
obo:CHEBI_35605 a rdfs:Class ;
rdfs:label "carbon oxoacid" ;
rdfs:subClassOf obo:CHEBI_24833 , obo:CHEBI_36963 .
obo:CHMO_0002774 a rdfs:Class ;
rdfs:label "stirring" ;
rdfs:comment "Mixing involving the agitation of a solution through circular motion." ;
rdfs:subClassOf obo:CHMO_0001685 .
obo:IAO_0000027 a rdfs:Class ;
rdfs:label "data item"@en ;
rdfs:comment "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en ;
rdfs:subClassOf obo:IAO_0000030 .
a rdfs:Class ;
rdfs:label "synthesis role" ;
rdfs:comment "A synthesis role is a role of a material that is participating in a synthesis (material conversion) process. [Allotrope]" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PROCO_0000001 a rdfs:Class ;
rdfs:label "synthetic chemical process"@en ;
rdfs:comment "Synthesis is a planned material process that combines, changes or converts material to produce a new material. [Allotrope]" ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CHMO_0002916 a rdfs:Class ;
rdfs:label "sample solidification" ;
rdfs:comment "Material processing in which a liquid or gas transitions into a solid." ;
rdfs:subClassOf obo:OBI_0000094 , obo:PROCO_0000051 .
obo:PROCO_0000271 a rdfs:Class ;
rdfs:label "ICH Q6A Class 1 Solvent" ;
rdfs:comment "Solvents to be avoided and with strict low limits as they are human carcinogens, strongly suspected human carcinogens, and environmental hazards." ;
rdfs:subClassOf obo:PROCO_0000270 .
a rdfs:Class ;
rdfs:label "reaction intermediate role" ;
rdfs:comment "Intermediate role is a role of material that is formed from reactants (or preceding intermediates) and reacts further to give the directly observed products of a chemical reaction. [Wikipedia]" ;
rdfs:subClassOf obo:OBI_0000086 .
obo:CHEBI_64047 a rdfs:Class ;
rdfs:label "food additive" ;
rdfs:comment "Any substance which is added to food to preserve or enhance its flavour and/or appearance." ;
rdfs:subClassOf obo:CHEBI_33232 , obo:CHEBI_78295 .
obo:CHEBI_64909 a rdfs:Class ;
rdfs:label "poison" ;
rdfs:comment "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:BFO_0000024 a rdfs:Class ;
rdfs:label "fiat object part"@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:CHEBI_48360 a rdfs:Class ;
rdfs:label "amphiprotic solvent" ;
rdfs:comment "Self-ionizing solvent possessing both characteristics of Bronsted acids and bases." ;
rdfs:subClassOf obo:CHEBI_48356 , obo:CHEBI_48359 .
a rdfs:Class ;
rdfs:label "to transfer" ;
rdfs:comment "To shift, or convey, a flow (material, energy, signal) from one place to another. [NIST]" ;
rdfs:subClassOf .
a rdf:Property ;
rdfs:label "has proper part" ;
rdfs:comment "Has proper part is an antisymmetric, irreflexive (normally transitive) relation between a whole and a distinct part. [SIO]" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:BFO_0000051 .
a rdf:Property ;
rdfs:label "facet of" ;
rdfs:comment "Facet of relates two information content entities where one information content entity is an aspect of the other one. [Allotrope]" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf .
a rdf:Property ;
rdfs:label "proper part of" ;
rdfs:comment "Inverse of has proper part. [Allotrope]" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:BFO_0000050 .
obo:BFO_0000179 a rdf:Property ;
rdfs:label "BFO OWL specification label"@en ;
rdfs:comment "Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification."@en ;
rdfs:range xsd:string .
obo:BFO_0000180 a rdf:Property ;
rdfs:label "BFO CLIF specification label"@en ;
rdfs:comment "Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2"@en ;
rdfs:range xsd:string .
obo:IAO_0000111 a rdf:Property ;
rdfs:label "editor preferred label" ;
rdfs:comment "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
rdfs:range xsd:string .
obo:IAO_0000112 a rdf:Property ;
rdfs:label "example of usage"@en ;
rdfs:comment "A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold."@en ;
rdfs:range xsd:string .
obo:IAO_0000114 a rdf:Property ;
rdfs:label "has curation status"@en ;
rdfs:range xsd:string .
obo:IAO_0000115 a rdf:Property ;
rdfs:label "textual definition" ;
rdfs:comment "The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en ;
rdfs:range xsd:string .
obo:IAO_0000116 a rdf:Property ;
rdfs:label "editor note"@en ;
rdfs:comment "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
rdfs:range xsd:string .
obo:IAO_0000117 a rdf:Property ;
rdfs:label "term editor"@en ;
rdfs:comment "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
rdfs:range xsd:string .
obo:IAO_0000118 a rdf:Property ;
rdfs:label "alternative term"@en ;
rdfs:comment "An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)"@en ;
rdfs:range xsd:string .
obo:IAO_0000119 a rdf:Property ;
rdfs:label "definition source"@en ;
rdfs:comment "Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
rdfs:range xsd:string .
obo:IAO_0000231 a rdf:Property ;
rdfs:label "has obsolescence reason"@en ;
rdfs:comment "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en ;
rdfs:range xsd:string .
obo:IAO_0000232 a rdf:Property ;
rdfs:label "curator note"@en ;
rdfs:comment "An administrative note of use for a curator but of no use for a user"@en ;
rdfs:range xsd:string .
obo:IAO_0000233 a rdf:Property ;
rdfs:label "term tracker item"@en ;
rdfs:comment "An IRI or similar locator for a request or discussion of an ontology term."@en ;
rdfs:range xsd:string .
obo:IAO_0000412 a rdf:Property ;
rdfs:label "imported from"@en ;
rdfs:comment "For external terms/classes, the ontology from which the term was imported"@en ;
rdfs:range xsd:string .
obo:IAO_0000589 a rdf:Property ;
rdfs:label "OBO foundry unique label"@en ;
rdfs:comment "An alternative name for a class or property which is unique across the OBO Foundry."@en ;
rdfs:range xsd:string .
obo:IAO_0000600 a rdf:Property ;
rdfs:label "elucidation"@en ;
rdfs:range xsd:string .
obo:IAO_0000601 a rdf:Property ;
rdfs:label "has associated axiom(nl)"@en ;
rdfs:range xsd:string .
obo:IAO_0000602 a rdf:Property ;
rdfs:label "has associated axiom(fol)"@en ;
rdfs:range xsd:string .
obo:OBI_0000295 a rdf:Property ;
rdfs:label "is_specified_input_of"@en ;
rdfs:comment "A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
rdfs:range obo:OBI_0000011 ;
rdfs:subPropertyOf obo:RO_0000056 .
obo:OBI_0000316 a rdf:Property ;
rdfs:label "obsolete_has_role"@en ;
rdfs:comment "A relation between a continuant C and a role R. The reciprocal relation of role_of." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf .
obo:OBI_0001847 a rdf:Property ;
rdfs:label "ISA alternative term"@en ;
rdfs:comment "An alternative term used by the ISA tools project (http://isa-tools.org)." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:IAO_0000118 .
obo:OBI_9991118 a rdf:Property ;
rdfs:label "IEDB alternative term" ;
rdfs:comment "An alternative term used by the IEDB." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:IAO_0000118 .
obo:PROCO_0000007 a rdf:Property ;
rdfs:label "monotropically related to"@en ;
rdfs:comment "is thermodynically preferred at all temperatures" ;
rdfs:range .
obo:PROCO_0000037 a rdf:Property ;
rdfs:label "enantiotropically related to"@en ;
rdfs:comment "a relationship between polymorphs that has a cross-over temperature at which one form becomes more thermodynamically favored than the other." ;
rdfs:range .
obo:PROCO_0000038 a rdf:Property ;
rdfs:label "is solvate of"@en ;
rdfs:comment "an object property that represents a relation between a chemical moiety and a physical form that incorporates solvent molecules either in the crystal lattice or by adsorption on the surface or in channels within the particles." ;
rdfs:range .
obo:PROCO_0000075 a rdf:Property ;
rdfs:label "is polymorph of"@en ;
rdfs:comment "an object property that represents a relation between polymorphs, i.e. different physical forms of the same chemical moiety." ;
rdfs:range .
obo:RO_0000053 a rdf:Property ;
rdfs:label "bearer of"@en ;
rdfs:comment "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence"@en ;
rdfs:range obo:BFO_0000020 .
obo:RO_0000080 a rdf:Property ;
rdfs:range .
obo:RO_0001015 a rdf:Property ;
rdfs:range .
obo:RO_0001025 a rdf:Property ;
rdfs:range .
obo:RO_0001900 a rdf:Property ;
rdfs:label "temporal interpretation"@en ;
rdfs:comment "An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context." ;
rdfs:range xsd:string .
obo:RO_0002233 a rdf:Property ;
rdfs:range .
obo:RO_0002502 a rdf:Property ;
rdfs:range .
a rdf:Property ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:range .
a rdfs:Datatype .
obo:IAO_0000078 a rdfs:Class ;
rdfs:label "curation status specification"@en ;
rdfs:comment "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
rdfs:subClassOf obo:IAO_0000102 .
obo:IAO_0000002 a obo:IAO_0000078 ;
rdfs:label "example to be eventually removed"@en .
obo:IAO_0000120 a obo:IAO_0000078 ;
rdfs:label "metadata complete"@en ;
rdfs:comment "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en .
obo:IAO_0000121 a obo:IAO_0000078 ;
rdfs:label "organizational term"@en ;
rdfs:comment "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en .
obo:IAO_0000122 a obo:IAO_0000078 ;
rdfs:label "ready for release"@en ;
rdfs:comment "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""@en .
obo:IAO_0000123 a obo:IAO_0000078 ;
rdfs:label "metadata incomplete"@en ;
rdfs:comment "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en .
obo:IAO_0000124 a obo:IAO_0000078 ;
rdfs:label "uncurated"@en ;
rdfs:comment "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en .
obo:IAO_0000125 a obo:IAO_0000078 ;
rdfs:label "pending final vetting"@en ;
rdfs:comment "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en .
obo:IAO_0000423 a obo:IAO_0000078 ;
rdfs:label "to be replaced with external ontology term"@en ;
rdfs:comment "Terms with this status should eventually replaced with a term from another ontology."@en .
obo:IAO_0000428 a obo:IAO_0000078 ;
rdfs:label "requires discussion"@en ;
rdfs:comment "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en .
obo:IAO_0000225 a rdfs:Class ;
rdfs:label "obsolescence reason specification"@en ;
rdfs:comment "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
rdfs:subClassOf obo:IAO_0000102 .
obo:IAO_0000103 a obo:IAO_0000225 ;
rdfs:label "failed exploratory term"@en ;
rdfs:comment "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"@en .
obo:IAO_0000226 a obo:IAO_0000225 ;
rdfs:label "placeholder removed"@en .
obo:IAO_0000227 a obo:IAO_0000225 ;
rdfs:label "terms merged"@en .
obo:IAO_0000228 a obo:IAO_0000225 ;
rdfs:label "term imported"@en .
obo:IAO_0000229 a obo:IAO_0000225 ;
rdfs:label "term split"@en .