PREFIX obo:
PREFIX rdf:
PREFIX rdfs:
PREFIX xsd:
obo:GO_0110165 a rdfs:Class ;
rdfs:label "cellular anatomical entity" ;
rdfs:comment "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." ;
rdfs:subClassOf obo:GO_0005575 , obo:UBERON_0000465 .
obo:BFO_0000051 a rdf:Property ;
rdfs:label "has part"@en ;
rdfs:comment "a core relation that holds between a whole and its part"@en ;
rdfs:range ;
rdfs:subPropertyOf obo:RO_0002131 .
obo:RO_0002450 a rdf:Property ;
rdfs:label "directly positively regulates activity of" ;
rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B.
For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.""" ;
rdfs:domain obo:BFO_0000040 ;
rdfs:range obo:BFO_0000040 ;
rdfs:subPropertyOf obo:RO_0002448 .
obo:RO_0002449 a rdf:Property ;
rdfs:label "directly negatively regulates activity of" ;
rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B.
For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.""" ;
rdfs:domain obo:BFO_0000040 ;
rdfs:range obo:BFO_0000040 ;
rdfs:subPropertyOf obo:RO_0002448 .
obo:RO_0002448 a rdf:Property ;
rdfs:label "directly regulates activity of" ;
rdfs:comment """The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.
A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.""" ;
rdfs:domain obo:BFO_0000040 ;
rdfs:range obo:BFO_0000040 ;
rdfs:subPropertyOf obo:RO_0011002 , obo:RO_0002436 .
obo:RO_0002506 a rdf:Property ;
rdfs:label "causal relation between entities" ;
rdfs:domain obo:BFO_0000002 ;
rdfs:range obo:BFO_0000002 ;
rdfs:subPropertyOf obo:RO_0002410 .
obo:RO_0011002 a rdf:Property ;
rdfs:label "regulates activity of" ;
rdfs:comment "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." ;
rdfs:domain obo:BFO_0000040 ;
rdfs:range obo:BFO_0000040 ;
rdfs:subPropertyOf obo:RO_0002566 .
obo:RO_0002566 a rdf:Property ;
rdfs:label "causally influences" ;
rdfs:comment "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." ;
rdfs:domain obo:BFO_0000002 ;
rdfs:range obo:BFO_0000002 ;
rdfs:subPropertyOf obo:RO_0002506 .
obo:RO_0000087 a rdf:Property ;
rdfs:label "has role"@en ;
rdfs:comment "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
rdfs:domain obo:BFO_0000004 ;
rdfs:range obo:BFO_0000023 ;
rdfs:subPropertyOf obo:RO_0000053 .
obo:RO_0002215 a rdf:Property ;
rdfs:label "capable of"@en ;
rdfs:comment "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " ;
rdfs:domain obo:BFO_0000004 ;
rdfs:range obo:BFO_0000015 ;
rdfs:subPropertyOf obo:RO_0002216 .
obo:RO_0000085 a rdf:Property ;
rdfs:label "has function"@en ;
rdfs:comment "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
rdfs:domain obo:BFO_0000004 ;
rdfs:range obo:BFO_0000034 ;
rdfs:subPropertyOf obo:RO_0000053 .
obo:RO_0002595 a rdf:Property ;
rdfs:label "causal relation between material entity and a process" ;
rdfs:comment "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ;
rdfs:domain obo:BFO_0000040 ;
rdfs:range obo:BFO_0000015 ;
rdfs:subPropertyOf obo:RO_0002410 .
obo:BFO_0000050 a rdf:Property ;
rdfs:label "part of" ;
rdfs:comment "a core relation that holds between a part and its whole"@en ;
rdfs:range obo:BFO_0000004 , obo:BFO_0000002 , obo:BFO_0000017 , obo:BFO_0000003 , obo:BFO_0000019 , obo:BFO_0000020 ;
rdfs:subPropertyOf obo:RO_0002131 .
obo:RO_0000091 a rdf:Property ;
rdfs:label "has disposition"@en ;
rdfs:comment "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence"@en ;
rdfs:domain obo:BFO_0000004 ;
rdfs:range obo:BFO_0000016 ;
rdfs:subPropertyOf obo:RO_0000053 .
obo:RO_0000056 a rdf:Property ;
rdfs:label "participates in"@en ;
rdfs:comment "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
rdfs:domain obo:BFO_0000002 ;
rdfs:range obo:BFO_0000003 .
obo:RO_0002434 a rdf:Property ;
rdfs:label "interacts with" ;
rdfs:comment "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." ;
rdfs:domain obo:BFO_0000040 ;
rdfs:range obo:BFO_0000040 .
obo:PBPKO_00158 a rdfs:Class ;
rdfs:label "fraction unbound fat" ;
rdfs:comment "An unbound fraction parameter specifically for the fat (adipose) compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:IAO_0000136 a rdf:Property ;
rdfs:label "is about"@en ;
rdfs:comment "A (currently) primitive relation that relates an information artifact to an entity."@en ;
rdfs:domain obo:IAO_0000030 ;
rdfs:range .
obo:PBPKO_00133 a rdfs:Class ;
rdfs:label "acid dissociation constant" ;
rdfs:comment "A physicochemical parameter representing the negative base-10 logarithm (pKa) of the acid dissociation constant (Ka)." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:UBERON_0000465 a rdfs:Class ;
rdfs:label "material anatomical entity" ;
rdfs:comment "Anatomical entity that has mass." ;
rdfs:subClassOf obo:BFO_0000040 , obo:UBERON_0001062 .
obo:PBPKO_00610 a rdfs:Class ;
rdfs:label "fraction of volume of compartment" ;
rdfs:comment "A physiological parameter representing the dimensionless fraction computed by dividing the volume of the compartment by the total body weight." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00110 a rdfs:Class ;
rdfs:label "fraction of surface area exposed" ;
rdfs:comment "A surface area parameter representing the fraction of skin surface area actually exposed." ;
rdfs:subClassOf obo:PBPKO_00010 .
obo:PBPKO_00586 a rdfs:Class ;
rdfs:label "restbodyfetus blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal rest of body compartment to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_03006 a rdfs:Class ;
rdfs:label "fecal excretion rate" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:NCBITaxon_117571 a rdfs:Class ;
rdfs:label "Euteleostomi" ;
rdfs:subClassOf obo:NCBITaxon_7742 .
obo:PBPKO_04056 a rdfs:Class ;
rdfs:label "fraction of feces" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_04023 a rdfs:Class ;
rdfs:label "plasma flow rate to lymph" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the lymph compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00091 a rdfs:Class ;
rdfs:label "volume of bone" ;
rdfs:comment "A volume parameter representing the total volume of bone compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06064 a rdfs:Class ;
rdfs:label "amount in kidney rest lumen" ;
rdfs:comment "The amount of compound in the rest of kidney lumen compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:BFO_0000034 a rdfs:Class ;
rdfs:label "function"@en ;
rdfs:subClassOf obo:BFO_0000016 .
obo:RO_0000079 a rdf:Property ;
rdfs:label "function of"@en ;
rdfs:comment "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ;
rdfs:domain obo:BFO_0000034 ;
rdfs:range ;
rdfs:subPropertyOf obo:RO_0000052 .
obo:OBI_0000947 a rdfs:Class ;
rdfs:label "service provider role" ;
rdfs:comment "is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person"@en ;
rdfs:subClassOf obo:BFO_0000023 .
obo:BFO_0000017 a rdfs:Class ;
rdfs:label "realizable entity"@en ;
rdfs:comment "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ;
rdfs:subClassOf obo:BFO_0000020 , obo:COB_0000502 .
obo:PBPKO_00003 a rdfs:Class ;
rdfs:label "physiologically based pharmacokinetic model" ;
rdfs:comment "A data representation model that predicts the absorption, distribution, metabolism, and excretion (ADME) of chemical substances in biological species based on physiological principles using mathematical modelling technique." ;
rdfs:subClassOf obo:OBI_0000658 .
obo:PBPKO_00378 a rdfs:Class ;
rdfs:label "volume of kidney fetus" ;
rdfs:comment "A volume parameter representing the total volume of the fetal kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_01501 a rdfs:Class ;
rdfs:label "pgp" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_00458 a rdfs:Class ;
rdfs:label "skin exposed stratum corneum compartment" ;
rdfs:comment "A stratum corneum compartment representing the portion directly exposed to the applied compound." ;
rdfs:subClassOf obo:PBPKO_00493 .
obo:PBPKO_00065 a rdfs:Class ;
rdfs:label "glomerular filtration rate" ;
rdfs:comment "A bodily fluid flow rate parameter (or physiological process measure) describing the flow rate of filtered fluid through the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00636 .
obo:IAO_0000009 a rdfs:Class ;
rdfs:label "datum label"@en ;
rdfs:comment "A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label"@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PBPKO_00545 a rdfs:Class ;
rdfs:label "concentration in bone marrow" ;
rdfs:comment "The total concentration of compound in the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_03070 a rdfs:Class ;
rdfs:label "fraction of FBS iin the medium" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06004 a rdfs:Class ;
rdfs:label "amount in stomach" ;
rdfs:comment "The amount of chemical in stomach compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00505 a rdfs:Class ;
rdfs:label "amount in bone marrow" ;
rdfs:comment "The amount of compound in the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00263 a rdfs:Class ;
rdfs:label "bioavailability" ;
rdfs:comment "An output parameter representing the rate and extent to which an active compound is absorbed and becomes available at the site of action or systemic circulation." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00575 a rdfs:Class ;
rdfs:label "kidney blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the kidney to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04102 a rdfs:Class ;
rdfs:label "fraction of bone non perfused" ;
rdfs:comment "A dimensionless fraction of volume defined as the bone non perfuse volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00144 a rdfs:Class ;
rdfs:label "enterohepatic recirculation" ;
rdfs:comment "A biological process involving recycling of compounds through the liver via biliary excretion, intestinal reabsorption, portal circulation return, and re-excretion." ;
rdfs:subClassOf obo:GO_0008150 .
obo:BFO_0000062 a rdf:Property ;
rdfs:label "preceded by"@en ;
rdfs:comment "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
rdfs:domain obo:BFO_0000003 ;
rdfs:range obo:BFO_0000003 ;
rdfs:subPropertyOf obo:RO_0002086 .
obo:BFO_0000063 a rdf:Property ;
rdfs:label "precedes"@en ;
rdfs:comment "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
rdfs:domain obo:BFO_0000003 ;
rdfs:range obo:BFO_0000003 ;
rdfs:subPropertyOf obo:RO_0002222 .
obo:RO_0002501 a rdf:Property ;
rdfs:label "causal relation between processes" ;
rdfs:comment "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." ;
rdfs:domain obo:BFO_0000003 ;
rdfs:range obo:BFO_0000003 ;
rdfs:subPropertyOf obo:RO_0002410 .
obo:RO_0019000 a rdf:Property ;
rdfs:label "regulates characteristic" ;
rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." ;
rdfs:domain obo:BFO_0000015 ;
rdfs:range obo:PATO_0000001 ;
rdfs:subPropertyOf obo:RO_0002410 .
obo:RO_0002233 a rdf:Property ;
rdfs:label "has input"@en ;
rdfs:comment "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
rdfs:domain obo:BFO_0000015 ;
rdfs:range obo:BFO_0000002 ;
rdfs:subPropertyOf obo:RO_0000057 .
obo:RO_0002211 a rdf:Property ;
rdfs:label "regulates"@en ;
rdfs:comment "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." ;
rdfs:domain obo:BFO_0000015 ;
rdfs:range obo:BFO_0000015 ;
rdfs:subPropertyOf obo:RO_0002411 .
obo:RO_0002018 a rdf:Property ;
rdfs:label "has component process" ;
rdfs:comment "w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
rdfs:domain obo:BFO_0000015 ;
rdfs:range obo:BFO_0000015 ;
rdfs:subPropertyOf obo:RO_0002180 .
obo:BFO_0000055 a rdf:Property ;
rdfs:label "realizes"@en ;
rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process"@en ;
rdfs:domain obo:BFO_0000015 ;
rdfs:range obo:BFO_0000017 .
obo:RO_0000057 a rdf:Property ;
rdfs:label "has participant"@en ;
rdfs:comment "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
rdfs:domain obo:BFO_0000003 ;
rdfs:range obo:BFO_0000002 .
obo:RO_0002222 a rdf:Property ;
rdfs:label "temporally related to"@en ;
rdfs:domain obo:BFO_0000003 ;
rdfs:range obo:BFO_0000003 .
obo:RO_0002334 a rdf:Property ;
rdfs:label "regulated by"@en ;
rdfs:comment "inverse of regulates" ;
rdfs:domain obo:BFO_0000015 ;
rdfs:range obo:BFO_0000015 ;
rdfs:subPropertyOf obo:RO_0002427 .
obo:PBPKO_03064 a rdfs:Class ;
rdfs:label "culture medium pH" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:OBI_0200172 a rdfs:Class ;
rdfs:label "partitioning objective"@en ;
rdfs:comment "A partitioning objective is a data transformation objective where the aim is to generate a collection of disjoint non-empty subsets whose union equals a non-empty input set."@en ;
rdfs:subClassOf obo:OBI_0200166 .
obo:OBI_0000833 a rdf:Property ;
rdfs:label "objective_achieved_by" ;
rdfs:comment "This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process."@en ;
rdfs:domain obo:IAO_0000005 ;
rdfs:range obo:COB_0000035 .
obo:PBPKO_00389 a rdfs:Class ;
rdfs:label "maximum rate in fetus" ;
rdfs:comment "A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in fetus when the enzyme is saturated with substrate." ;
rdfs:subClassOf obo:PBPKO_00613 .
obo:OBI_0001933 a rdfs:Class ;
rdfs:label "value specification" ;
rdfs:comment "An information content entity that specifies a value within a classification scheme or on a quantitative scale."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PBPKO_04107 a rdfs:Class ;
rdfs:label "volume of kidney proximal tubule lumen" ;
rdfs:comment "A volume parameter representing the total volume of the lumen of kidney proximal tubule compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00121 a rdfs:Class ;
rdfs:label "arterial volume" ;
rdfs:comment "A volume parameter representing the total volume of the arterial compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:OBI_0000663 a rdfs:Class ;
rdfs:label "class prediction data transformation"@en ;
rdfs:comment "A class prediction data transformation (sometimes called supervised classification) is a data transformation that has objective class prediction."@en ;
rdfs:subClassOf obo:OBI_0200000 .
obo:OBI_0000417 a rdf:Property ;
rdfs:label "achieves_planned_objective" ;
rdfs:comment "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process."@en ;
rdfs:domain obo:COB_0000035 ;
rdfs:range obo:IAO_0000005 .
obo:OBI_0000293 a rdf:Property ;
rdfs:label "has specified input"@en ;
rdfs:comment "The inverse property of is specified input of" ;
rdfs:domain obo:COB_0000035 ;
rdfs:range obo:IAO_0000027 , obo:OBI_0000648 , obo:BFO_0000002 ;
rdfs:subPropertyOf obo:RO_0000057 .
obo:OBI_0000299 a rdf:Property ;
rdfs:label "has specified output"@en ;
rdfs:comment "The inverse property of is specified output of" ;
rdfs:domain obo:COB_0000035 ;
rdfs:range obo:BFO_0000002 ;
rdfs:subPropertyOf obo:RO_0000057 .
obo:PBPKO_03010 a rdfs:Class ;
rdfs:label "kinetic absorption rate from jejunum lumen to intestinal tissue" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00332 a rdfs:Class ;
rdfs:label "lifestage" ;
rdfs:comment "A physiological parameter representing distinct phases of an individual's life (e.g., infant, adult, geriatric)." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00139 a rdfs:Class ;
rdfs:label "biochemical parameter" ;
rdfs:comment "A parameter that is compound-dependent and relates to biological interactions or transformations (e.g., clearance, binding, partition coefficients)." ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:PBPKO_00230 a rdfs:Class ;
rdfs:label "fecal clearance rate" ;
rdfs:comment "A clearance rate specifically quantifying elimination via feces." ;
rdfs:subClassOf obo:PBPKO_00229 .
obo:OBI_0200042 a rdfs:Class ;
rdfs:label "hierarchical clustering"@en ;
rdfs:comment "A hierarchical clustering is a data transformation which achieves a class discovery objective, which takes as input data item and builds a hierarchy of clusters. The traditional representation of this hierarchy is a tree (visualized by a dendrogram), with the individual input objects at one end (leaves) and a single cluster containing every object at the other (root)."@en ;
rdfs:subClassOf obo:OBI_0200175 .
obo:PBPKO_04001 a rdfs:Class ;
rdfs:label "plasma flow rate" ;
rdfs:comment "A bodily fluid flow rate parameter specifically describing the flow of plasma to a compartment." ;
rdfs:subClassOf obo:PBPKO_00636 .
obo:PBPKO_00303 a rdfs:Class ;
rdfs:label "permeability limited pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model that considers the permeability across membranes as a limiting factor for compound distribution." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_10009 a rdf:Property ;
rdfs:range .
obo:PBPKO_10002 a rdf:Property ;
rdfs:range .
obo:PBPKO_10006 a rdf:Property ;
rdfs:range .
obo:PBPKO_10007 a rdf:Property ;
rdfs:range .
obo:PBPKO_10001 a rdf:Property ;
rdfs:range .
obo:PBPKO_10008 a rdf:Property ;
rdfs:range .
obo:PBPKO_10004 a rdf:Property ;
rdfs:range .
obo:PBPKO_03025 a rdfs:Class ;
rdfs:label "maximum capacity of binding sites in red cells" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00169 a rdfs:Class ;
rdfs:label "pancreas plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in pancreas to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00324 a rdfs:Class ;
rdfs:label "non-linear elimination" ;
rdfs:comment "An elimination process that does not follow first-order kinetics (e.g., saturable processes)." ;
rdfs:subClassOf obo:PBPKO_00322 .
obo:PBPKO_00054 a rdfs:Class ;
rdfs:label "blood flow rate to portal vein" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the portal vein compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_06015 a rdfs:Class ;
rdfs:label "amount in intestinal tissue" ;
rdfs:comment "The amount of chemical in intestinal tissue" ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00494 a rdfs:Class ;
rdfs:label "transverse colon compartment" ;
rdfs:comment "A large intestine compartment representing the transverse colon." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_06037 a rdfs:Class ;
rdfs:label "total venous bone marrow concentration" ;
rdfs:comment "The total venous concentration of compound in the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00191 a rdfs:Class ;
rdfs:label "phase I metabolism" ;
rdfs:comment "A metabolism process involving the conversion of exogenous substances to more polar metabolites, often via oxidation, reduction, or hydrolysis (e.g., by CYPs)." ;
rdfs:subClassOf obo:GO_0008152 .
obo:PBPKO_00241 a rdfs:Class ;
rdfs:label "dermal exposure" ;
rdfs:comment "A route of exposure via the skin." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00126 a rdfs:Class ;
rdfs:label "physicochemical parameter" ;
rdfs:comment "A parameter relating to the physical and chemical properties of a compound (e.g., MW, lipophilicity, solubility, pKa)." ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:PBPKO_03036 a rdfs:Class ;
rdfs:label "octanol water partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04030 a rdfs:Class ;
rdfs:label "plasma flow rate to bone marrow" ;
rdfs:comment "A plasma flow parameter specifically describing the rate to the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00343 a rdfs:Class ;
rdfs:label "geriatric lifestage" ;
rdfs:comment "A lifestage parameter representing older adults, often considered 60/65 years and older." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_04078 a rdfs:Class ;
rdfs:label "volume of skin surface depot" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00035 a rdfs:Class ;
rdfs:label "fraction of blood flow to gonad" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the gonad compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_04073 a rdfs:Class ;
rdfs:label "volume of testis" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00508 a rdfs:Class ;
rdfs:label "fraction of filtrate" ;
rdfs:comment "A dimensionless fraction of volume defined as the filtrate volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:COB_0000022 a rdfs:Class ;
rdfs:label "organism"@en ;
rdfs:comment "A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome"@en ;
rdfs:subClassOf obo:UBERON_0000465 .
obo:PBPKO_00077 a rdfs:Class ;
rdfs:label "volume of liver" ;
rdfs:comment "A volume parameter representing the total volume of the liver compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00364 a rdfs:Class ;
rdfs:label "cerebrum brain partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the cerebrum to the overall brain." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00429 a rdfs:Class ;
rdfs:label "bile salt effect solubilization ratio" ;
rdfs:comment "A biochemical parameter representing the ratio of molecules solubilized due to bile salt presence." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_03047 a rdfs:Class ;
rdfs:label "abiotic degradation rate in air" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00549 a rdfs:Class ;
rdfs:label "concentration in plasma" ;
rdfs:comment "The total concentration of compound in the plasma compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:OBI_0000792 a rdfs:Class ;
rdfs:label "statistical model validation" ;
rdfs:comment "A data transformation which assesses how the results of a statistical analysis will generalize to an independent data set."@en ;
rdfs:subClassOf obo:OBI_0200171 .
obo:PBPKO_03014 a rdfs:Class ;
rdfs:label "apparent Caco-2 permeability" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06067 a rdfs:Class ;
rdfs:label "amount in liver intracellular" ;
rdfs:comment "The amount of compound in the intracellular spaceof liver compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:IAO_0000183 a rdfs:Class ;
rdfs:label "dendrogram"@en ;
rdfs:comment """A dendrogram is a report graph which is a tree diagram
frequently used to illustrate the arrangement of the clusters produced by a
clustering algorithm."""@en ;
rdfs:subClassOf obo:IAO_0000038 .
obo:COB_0000080 a rdfs:Class ;
rdfs:label "complex of molecules"@en ;
rdfs:comment "A complex of two or more molecules that are not covalently bound."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00189 a rdfs:Class ;
rdfs:label "catalytic rate constant" ;
rdfs:comment "A biochemical parameter quantifying enzymatic reaction velocity (kcat), representing the maximum number of substrate molecules converted per active site per unit time." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00487 a rdfs:Class ;
rdfs:label "placental barrier compartment" ;
rdfs:comment "A barrier compartment representing the placental barrier separating maternal and fetal circulation." ;
rdfs:subClassOf obo:PBPKO_00495 .
obo:PBPKO_00469 a rdfs:Class ;
rdfs:label "dermis compartment" ;
rdfs:comment "A skin compartment representing the dermis layer." ;
rdfs:subClassOf obo:PBPKO_00470 .
obo:COB_0000011 a rdfs:Class ;
rdfs:label "atom"@en ;
rdfs:comment "A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00255 a rdfs:Class ;
rdfs:label "maximum time" ;
rdfs:comment "An output parameter representing the time (Tmax) required to reach the peak concentration." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00480 a rdfs:Class ;
rdfs:label "heart compartment" ;
rdfs:comment "A compartment representing the heart." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_01505 a rdfs:Class ;
rdfs:label "nctp" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:NCBITaxon_314146 a rdfs:Class ;
rdfs:label "Euarchontoglires" ;
rdfs:subClassOf obo:NCBITaxon_40674 .
obo:PBPKO_00511 a rdfs:Class ;
rdfs:label "fraction of blood flow to filtrate" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the filtrate compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00353 a rdfs:Class ;
rdfs:label "cranial cerebrospinal fluid flow rate" ;
rdfs:comment "A bodily fluid flow rate parameter representing the flow rate of cerebrospinal fluid (CSF) compartment in the cranial region." ;
rdfs:subClassOf obo:PBPKO_00636 .
obo:PBPKO_00534 a rdfs:Class ;
rdfs:label "urinary rate" ;
rdfs:comment "A biochemical parameter representing the rate at which a compound is cleared via urine." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00088 a rdfs:Class ;
rdfs:label "fraction of gonad" ;
rdfs:comment "A dimensionless fraction of volume defined as the gonad volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00629 a rdfs:Class ;
rdfs:label "amount in richly perfused tissue" ;
rdfs:comment "The amount of compound in the richly perfused tissue compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_04067 a rdfs:Class ;
rdfs:label "volume of thyroid" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06048 a rdfs:Class ;
rdfs:label "concentration in bile" ;
rdfs:comment "The concentration of chemical in bile." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_04059 a rdfs:Class ;
rdfs:label "skin area" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_06012 a rdfs:Class ;
rdfs:label "amount in bile" ;
rdfs:comment "The amount of chemical in bile." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00266 a rdfs:Class ;
rdfs:label "mean dissolution time" ;
rdfs:comment "An output parameter representing the average time for a compound to dissolve in the body (MDT)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00527 a rdfs:Class ;
rdfs:label "hematocrit volume" ;
rdfs:comment "A volume parameter representing the total volume of red blood cells in whole blood." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00009 a rdfs:Class ;
rdfs:label "height" ;
rdfs:comment "A physiological parameter describing the distance from the bottom to the top of someone standing upright." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_04005 a rdfs:Class ;
rdfs:label "plasma flow rate to large intestine" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the large intestine compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00115 a rdfs:Class ;
rdfs:label "volume of gall bladder" ;
rdfs:comment "A volume parameter representing the total volume of the gall bladder compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00522 a rdfs:Class ;
rdfs:label "volume of filtrate" ;
rdfs:comment "A volume parameter representing the total volume of the filtrate compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00556 a rdfs:Class ;
rdfs:label "urine compartment" ;
rdfs:comment "An excreta compartment specifically representing urine." ;
rdfs:subClassOf obo:PBPKO_00554 .
obo:PBPKO_04012 a rdfs:Class ;
rdfs:label "plasma flow rate to gonad" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the gonad compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00177 a rdfs:Class ;
rdfs:label "bone plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in bone to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00498 a rdfs:Class ;
rdfs:label "amount in kidney" ;
rdfs:comment "The amount of compound in the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00418 a rdfs:Class ;
rdfs:label "blood flow rate to cecum" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the cecum compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_03009 a rdfs:Class ;
rdfs:label "kinetic emptying rate from ileum lumen to large intestine lumen" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00107 a rdfs:Class ;
rdfs:label "volume of stratum corneum with respect to blood" ;
rdfs:comment "A volume parameter representing the total volume of stratum corneum compartment with respect to blood/plasma." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00375 a rdfs:Class ;
rdfs:label "volume of amniotic fluid" ;
rdfs:comment "A volume parameter representing the total volume of the amniotic fluid compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00282 a rdfs:Class ;
rdfs:label "percentile 2.5 cplasma" ;
rdfs:comment "A plasma concentration parameter representing the 2.5th percentile of the plasma concentration distribution in a population simulation." ;
rdfs:subClassOf obo:PBPKO_00549 .
obo:PBPKO_00010 a rdfs:Class ;
rdfs:label "surface area" ;
rdfs:comment "A physiological parameter representing the total area that the surface of an object occupies." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00313 a rdfs:Class ;
rdfs:label "endosomal space compartment" ;
rdfs:comment "A compartment representing the endosomal space within cells." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00567 a rdfs:Class ;
rdfs:label "bone blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in bone to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00509 a rdfs:Class ;
rdfs:label "fraction of gut" ;
rdfs:comment "A dimensionless fraction of volume defined as the gut volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:OBI_0000835 a rdfs:Class ;
rdfs:label "manufacturer" ;
rdfs:comment "A person or organization that has a manufacturer role."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00440 a rdfs:Class ;
rdfs:label "phmilk" ;
rdfs:comment "A biochemical parameter representing the pH of milk." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00359 a rdfs:Class ;
rdfs:label "blood flow rate to hippocampus" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the hippocampus compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00466 a rdfs:Class ;
rdfs:label "brain compartment" ;
rdfs:comment "A compartment representing the brain." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00046 a rdfs:Class ;
rdfs:label "blood flow rate to poorly perfused" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the poorly perfused organ/tissue compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_04048 a rdfs:Class ;
rdfs:label "diameter of the ileum lumen" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_03075 a rdfs:Class ;
rdfs:label "absorption rate constant" ;
rdfs:comment "A biochemical parameter representing the rate constant at which a compound is absorbed into systemic circulation or a target compartment from the site of administration" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00426 a rdfs:Class ;
rdfs:label "volume of ileum" ;
rdfs:comment "A volume parameter representing the total volume of the ileum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_02011 a rdfs:Class ;
rdfs:label "liver intracellular space compartment" ;
rdfs:comment "A compartment representing intracellular space of the liver." ;
rdfs:subClassOf obo:PBPKO_00558 .
obo:OBI_0000023 a rdfs:Class ;
rdfs:label "classified data set"@en ;
rdfs:comment "A data set that is produced as the output of a class prediction data transformation and consists of a data set with assigned class labels."@en ;
rdfs:subClassOf obo:IAO_0000100 .
obo:OBI_0000312 a rdf:Property ;
rdfs:label "is specified output of"@en ;
rdfs:comment "A relation between a completely executed planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
rdfs:domain obo:BFO_0000002 ;
rdfs:range obo:COB_0000035 ;
rdfs:subPropertyOf obo:RO_0000056 .
obo:PBPKO_00021 a rdfs:Class ;
rdfs:label "fraction of blood flow to large intestine" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the large intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00566 a rdfs:Class ;
rdfs:label "stomach compartment" ;
rdfs:comment "A digestive system compartment representing the stomach." ;
rdfs:subClassOf obo:PBPKO_00553 .
obo:BFO_0000029 a rdfs:Class ;
rdfs:label "site"@en ;
rdfs:subClassOf obo:BFO_0000141 .
obo:PBPKO_03018 a rdfs:Class ;
rdfs:label "intrinsic absorption rate of metabilite" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00483 a rdfs:Class ;
rdfs:label "mammary gland compartment" ;
rdfs:comment "A compartment representing the mammary gland." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00184 a rdfs:Class ;
rdfs:label "skin diffusion coefficient" ;
rdfs:comment "A diffusion coefficient representing the diffusion of a compound across the skin." ;
rdfs:subClassOf obo:PBPKO_00431 .
obo:PBPKO_00248 a rdfs:Class ;
rdfs:label "subcutaneous exposure" ;
rdfs:comment "A route of exposure involving administration under the skin." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_04086 a rdfs:Class ;
rdfs:label "fraction of intestinal lumen" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00618 a rdfs:Class ;
rdfs:label "cerebrum compartment" ;
rdfs:comment "A part of brain compartment representing the cerebrum region of the brain" ;
rdfs:subClassOf obo:PBPKO_00466 .
obo:PBPKO_02009 a rdfs:Class ;
rdfs:label "kidney proximal tubule tissue compartment" ;
rdfs:comment "A compartment representing rest of the tissue of kidney." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_00410 a rdfs:Class ;
rdfs:label "fraction of blood flow to jejunum" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the jejunum compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00314 a rdfs:Class ;
rdfs:label "interstitial space" ;
rdfs:comment "A physiological parameter representing the fluid-filled space between blood vessels and cells." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00031 a rdfs:Class ;
rdfs:label "fraction of blood flow to heart" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the heart compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00552 a rdfs:Class ;
rdfs:label "arterial blood compartment" ;
rdfs:comment "A compartment representing the arterial blood." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00651 a rdfs:Class ;
rdfs:label "fraction of arterial blood volume" ;
rdfs:comment "A dimensionless fraction of volume defined as the arterial blood volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_06045 a rdfs:Class ;
rdfs:label "concentration in large intestine" ;
rdfs:comment "The concentration of chemical in large intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00404 a rdfs:Class ;
rdfs:label "extrathoracic compartment" ;
rdfs:comment "A compartment representing the extrathoracic region (head, neck, upper respiratory tract)." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_04096 a rdfs:Class ;
rdfs:label "fraction of urinary tract" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00555 a rdfs:Class ;
rdfs:label "feces compartment" ;
rdfs:comment "An excreta compartment specifically representing feces." ;
rdfs:subClassOf obo:PBPKO_00554 .
obo:GO_0044423 a rdfs:Class ;
rdfs:label "virion component" ;
rdfs:comment "Any constituent part of a virion, a complete fully infectious extracellular virus particle." ;
rdfs:subClassOf obo:GO_0005575 .
obo:PBPKO_00104 a rdfs:Class ;
rdfs:label "fraction of plasma" ;
rdfs:comment "A dimensionless fraction of volume defined as the plasma volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_01509 a rdfs:Class ;
rdfs:label "oat4" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_00036 a rdfs:Class ;
rdfs:label "blood flow rate to skin" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00538 a rdfs:Class ;
rdfs:label "concentration in gut" ;
rdfs:comment "The total concentration of compound in the gut compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00213 a rdfs:Class ;
rdfs:label "maximum rate in liver" ;
rdfs:comment "A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in the liver when the enzyme is saturated with substrate." ;
rdfs:subClassOf obo:PBPKO_00613 .
obo:PBPKO_00476 a rdfs:Class ;
rdfs:label "gall bladder compartment" ;
rdfs:comment "A digestive system compartment representing the gall bladder." ;
rdfs:subClassOf obo:PBPKO_00553 .
obo:GO_0032501 a rdfs:Class ;
rdfs:label "multicellular organismal process" ;
rdfs:subClassOf obo:GO_0008150 .
obo:PBPKO_00397 a rdfs:Class ;
rdfs:label "filtrate compartment" ;
rdfs:comment "A kidney compartment representing the filtrate within the nephron." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_00224 a rdfs:Class ;
rdfs:label "hepatic excretion" ;
rdfs:comment "An excretion process involving the elimination of compounds and metabolites via the liver (often into bile)." ;
rdfs:subClassOf obo:GO_0007588 .
obo:PBPKO_00173 a rdfs:Class ;
rdfs:label "heart plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in heart to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00625 a rdfs:Class ;
rdfs:label "exposed skin compartment" ;
rdfs:comment "A skin compartment representing the exposed part of the skin to the chemical via dermal contact." ;
rdfs:subClassOf obo:PBPKO_00470 .
obo:PBPKO_04063 a rdfs:Class ;
rdfs:label "area of exposed skin" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00367 a rdfs:Class ;
rdfs:label "apparent permeability cerebrum to rest of brain" ;
rdfs:comment "Apparent permeability of a compound specifically between the cerebrum and the rest of the brain." ;
rdfs:subClassOf obo:PBPKO_00612 .
obo:PBPKO_00640 a rdfs:Class ;
rdfs:label "amount in skin stratum corneum of exposed skin" ;
rdfs:comment "The amount of chemical in skin stratum corneum of exposed skin" ;
rdfs:subClassOf obo:PBPKO_00506 .
obo:PBPKO_04015 a rdfs:Class ;
rdfs:label "plasma flow rate to brain" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the brain compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00512 a rdfs:Class ;
rdfs:label "fraction of blood flow to bone marrow" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00289 a rdfs:Class ;
rdfs:label "reference dose" ;
rdfs:comment "An output parameter (or exposure limit) estimating the daily oral or dermal exposure likely to be without appreciable risk over a lifetime (RfD)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_04037 a rdfs:Class ;
rdfs:label "plasma flow rate to skin stratum corneum exposed" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the exposed stratum corneum compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00025 a rdfs:Class ;
rdfs:label "fraction of blood flow to liver" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the liver compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00386 a rdfs:Class ;
rdfs:label "blood flow rate to restbody fetus" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the rest of body compartment within the fetus." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_04004 a rdfs:Class ;
rdfs:label "plasma flow rate to small intestine" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the small intestine compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_04070 a rdfs:Class ;
rdfs:label "volume of large intestinal lumen" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00014 a rdfs:Class ;
rdfs:label "blood flow rate to stomach" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the stomach compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:OBI_0001468 a rdfs:Class ;
rdfs:label "cell specimen" ;
rdfs:comment "A specimen primarily composed of a cell or cells collected from a multicellular organism or a cell culture."@en ;
rdfs:subClassOf obo:OBI_0001479 .
obo:PBPKO_00237 a rdfs:Class ;
rdfs:label "renal elimination rate constant" ;
rdfs:comment "A biochemical parameter representing the rate constant for elimination via renal (urinary) excretion." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04041 a rdfs:Class ;
rdfs:label "volume of small intestine tissue" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06055 a rdfs:Class ;
rdfs:label "concentration in cell" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_04009 a rdfs:Class ;
rdfs:label "plasma flow rate to muscle" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the muscle compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:NCBITaxon_33208 a rdfs:Class ;
rdfs:label "Metazoa" ;
rdfs:subClassOf obo:NCBITaxon_33154 .
obo:PBPKO_00306 a rdfs:Class ;
rdfs:label "maximum rate of apical transporter in vitro" ;
rdfs:comment "A maximum rate (Vmax) of an enzyme catalysed reaction for a compound across the apical membrane of an organ, measured in vitro, when the enzyme is saturated with substrate." ;
rdfs:subClassOf obo:PBPKO_00613 .
obo:PBPKO_06042 a rdfs:Class ;
rdfs:label "concentration in small intestine" ;
rdfs:comment "The concentration of chemical in small intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00523 a rdfs:Class ;
rdfs:label "volume of bone marrow" ;
rdfs:comment "A volume parameter representing the total volume of the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00055 a rdfs:Class ;
rdfs:label "fraction of blood flow to portal vein" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the portal vein compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00455 a rdfs:Class ;
rdfs:label "viable unexposed skin compartment" ;
rdfs:comment "A skin compartment representing the viable layers of skin not directly exposed to the applied compound." ;
rdfs:subClassOf obo:PBPKO_00470 .
obo:PBPKO_00317 a rdfs:Class ;
rdfs:label "top-down pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model approach primarily based on fitting observed clinical data, often empirical." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00108 a rdfs:Class ;
rdfs:label "volume of blood" ;
rdfs:comment "A volume parameter representing the total volume of blood compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_03058 a rdfs:Class ;
rdfs:label "fraction of neutral lipids in the FBS" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00415 a rdfs:Class ;
rdfs:label "blood flow rate to jejunum" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the jejunum compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00407 a rdfs:Class ;
rdfs:label "alveolar compartment" ;
rdfs:comment "A lung compartment representing the alveoli." ;
rdfs:subClassOf obo:PBPKO_00559 .
obo:OBI_0000684 a rdfs:Class ;
rdfs:label "specimen collection objective" ;
rdfs:comment "A objective specification that is fulfilled by obtaining a material entity for potential use as an input upon which measurements or observations are performed."@en ;
rdfs:subClassOf obo:IAO_0000005 .
obo:PBPKO_00563 a rdfs:Class ;
rdfs:label "blood flow rate to exposed skin" ;
rdfs:comment "A blood flow rate to skin parameter specifically describing the rate to the exposed portion of the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00036 .
obo:PBPKO_00340 a rdfs:Class ;
rdfs:label "middle age lifestage" ;
rdfs:comment "A lifestage parameter representing individuals typically from thirty to forty-five years old." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_00042 a rdfs:Class ;
rdfs:label "blood flow rate to spleen" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the spleen compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_02006 a rdfs:Class ;
rdfs:label "glomerulus compartment" ;
rdfs:comment "A part of kidney compartment in the model representing glomerulus in the body" ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_03069 a rdfs:Class ;
rdfs:label "volume of medium" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00318 a rdfs:Class ;
rdfs:label "bottom-up pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model approach built mechanistically using in vitro and physiological data." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00533 a rdfs:Class ;
rdfs:label "blood flow rate for mass balance" ;
rdfs:comment "A blood flow rate parameter representing the check for total blood flow mass balance of all the compartments (sum of organ flows should equal cardiac output)." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00356 a rdfs:Class ;
rdfs:label "volume of frontal cortex" ;
rdfs:comment "A volume parameter representing the total volume of the frontal cortex compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06008 a rdfs:Class ;
rdfs:label "amount in large intestine" ;
rdfs:comment "The amount of chemical in large intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_04052 a rdfs:Class ;
rdfs:label "surface area of the large intestine lumen" ;
rdfs:subClassOf obo:PBPKO_00010 .
obo:PBPKO_06031 a rdfs:Class ;
rdfs:label "total venous gut concentration" ;
rdfs:comment "The total venous concentration of compound in the gut compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00260 a rdfs:Class ;
rdfs:label "area under moment curve" ;
rdfs:comment "An output parameter calculated as the integral of the product of time and concentration versus time (AUMC)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00252 a rdfs:Class ;
rdfs:label "output parameter" ;
rdfs:comment "A parameter representing a result or prediction generated by the PBPK model." ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:IAO_0001000 a rdfs:Class ;
rdfs:label "data collection"@en ;
rdfs:comment "A data entity that consists of multiple data entities."@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:UBERON_0001062 a rdfs:Class ;
rdfs:label "anatomical entity" ;
rdfs:comment "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." .
obo:PBPKO_00128 a rdfs:Class ;
rdfs:label "lipophillicity" ;
rdfs:comment "A physicochemical parameter representing the affinity or tendency of a compound to dissolve in lipids or hydrophobic environments." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00519 a rdfs:Class ;
rdfs:label "tissue plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in a generic tissue to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00101 a rdfs:Class ;
rdfs:label "volume of richly perfused" ;
rdfs:comment "A volume parameter representing the total volume of the richly perfused compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00390 a rdfs:Class ;
rdfs:label "amniotic transfer coefficient" ;
rdfs:comment "A biochemical parameter representing the rate at which a compound transfers from maternal circulation to amniotic fluid." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00582 a rdfs:Class ;
rdfs:label "muscle blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in muscle to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
a rdfs:Class .
obo:PBPKO_06020 a rdfs:Class ;
rdfs:label "unbound venous brain concentration" ;
rdfs:comment "The unbound venous concentration of compound in the brain compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_00080 a rdfs:Class ;
rdfs:label "fraction of kidney" ;
rdfs:comment "A dimensionless fraction of volume defined as the kidney volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00437 a rdfs:Class ;
rdfs:label "fraction unbound milk" ;
rdfs:comment "An unbound fraction parameter specifically for milk." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00154 a rdfs:Class ;
rdfs:label "fraction unbound liver" ;
rdfs:comment "An unbound fraction parameter specifically for the liver compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00571 a rdfs:Class ;
rdfs:label "gonad blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in gonads to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00117 a rdfs:Class ;
rdfs:label "volume of portal vein" ;
rdfs:comment "A volume parameter representing the total volume of the portal vein compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_01502 a rdfs:Class ;
rdfs:label "mrp2" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_04026 a rdfs:Class ;
rdfs:label "plasma flow rate to ileum" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the ileum compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00540 a rdfs:Class ;
rdfs:label "concentration in brain" ;
rdfs:comment "The total concentration of compound in the brain compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00180 a rdfs:Class ;
rdfs:label "rich perfused plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the lumped richly perfused compartment to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00448 a rdfs:Class ;
rdfs:label "alveolar air compartment" ;
rdfs:comment "A lung compartment specifically representing the air within the alveoli." ;
rdfs:subClassOf obo:PBPKO_00559 .
obo:PBPKO_00137 a rdfs:Class ;
rdfs:label "hydrogen donor count" ;
rdfs:comment "A physicochemical parameter representing the integer number of hydrogen bond donors in a molecular entity." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00541 a rdfs:Class ;
rdfs:label "concentration in kidney" ;
rdfs:comment "The total concentration of compound in the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00472 a rdfs:Class ;
rdfs:label "small intestine compartment" ;
rdfs:comment "A digestive system compartment representing the small intestine." ;
rdfs:subClassOf obo:PBPKO_00553 .
obo:PBPKO_03042 a rdfs:Class ;
rdfs:label "medium microsomes partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_06068 a rdfs:Class ;
rdfs:label "amount in liver extracellular" ;
rdfs:comment "The amount of compound in the extracellular space of liver compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_06034 a rdfs:Class ;
rdfs:label "total venous filtrate concentration" ;
rdfs:comment "The total venous concentration of compound in the filtrate compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_06007 a rdfs:Class ;
rdfs:label "amount in ileum" ;
rdfs:comment "The amount of chemical in ileum compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00148 a rdfs:Class ;
rdfs:label "protein binding mediated distributiion process" ;
rdfs:comment "A distribution process (or molecular function) where substances bind to proteins or related compounds." ;
rdfs:subClassOf obo:PBPKO_00146 .
obo:PBPKO_03073 a rdfs:Class ;
rdfs:label "fraction unbound in the FBS" ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00421 a rdfs:Class ;
rdfs:label "fraction of ileum" ;
rdfs:comment "A dimensionless fraction of volume defined as the ileum volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_06019 a rdfs:Class ;
rdfs:label "unbound venous gut concentration" ;
rdfs:comment "The unbound venous concentration of compound in the gut compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:COB_0000021 a rdfs:Class ;
rdfs:label "gross anatomical part"@en ;
rdfs:comment "A part of a multicellular organism that is a collection of cell components that are not all contained in one cell."@en ;
rdfs:subClassOf obo:UBERON_0000465 .
obo:PBPKO_03074 a rdfs:Class ;
rdfs:label "fraction unbound in the cell" ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00220 a rdfs:Class ;
rdfs:label "abcc2" ;
rdfs:comment "A transporter (ATP-binding cassette subfamily C member 2) involved in transporting various molecules across cell membranes." ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_00501 a rdfs:Class ;
rdfs:label "amount in restbody" ;
rdfs:comment "The amount of compound in the rest of the body compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_03002 a rdfs:Class ;
rdfs:label "intrinsic absorption rate" ;
rdfs:comment "The absorption rate constant parameter representing the intrinsic absorption rate from the gut or any intestinal segment to the liver or the portal vein" ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:PBPKO_00244 a rdfs:Class ;
rdfs:label "intravenous infusion exposure" ;
rdfs:comment "A route of exposure involving continuous administration directly into a vein over time." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00320 a rdfs:Class ;
rdfs:label "central compartment" ;
rdfs:comment "A compartment in a multi-compartment model representing plasma and highly perfused tissues where distribution is rapid." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00636 a rdfs:Class ;
rdfs:label "bodily fluid flow rate parameter" ;
rdfs:comment "A physiological parameter representing the rate of fluid flow to a particular compartment." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_06052 a rdfs:Class ;
rdfs:label "maximum amount" ;
rdfs:comment "The maximum amount of chemical in a compartment" ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00285 a rdfs:Class ;
rdfs:label "reconstructed exposure" ;
rdfs:comment "An output parameter estimating the amount of compound exposure based on internal body measurements." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_03062 a rdfs:Class ;
rdfs:label "well depth" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00544 a rdfs:Class ;
rdfs:label "concentration in fat" ;
rdfs:comment "The total concentration of compound in the fat compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:IAO_0000308 a rdfs:Class ;
rdfs:label "figure"@en ;
rdfs:comment "An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PBPKO_00165 a rdfs:Class ;
rdfs:label "partition coefficient" ;
rdfs:comment "A biochemical parameter representing the ratio of the concentration of a compound in a particular tissue to its concentration in plasma/blood at equilibrium." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00099 a rdfs:Class ;
rdfs:label "volume of poorly perfused" ;
rdfs:comment "A volume parameter representing the total volume of the poorly perfused compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00463 a rdfs:Class ;
rdfs:label "ascending colon compartment" ;
rdfs:comment "A large intestine compartment representing the ascending colon." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_00491 a rdfs:Class ;
rdfs:label "sigmoid colon compartment" ;
rdfs:comment "A large intestine compartment representing the sigmoid colon." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_00122 a rdfs:Class ;
rdfs:label "venous volume" ;
rdfs:comment "A volume parameter representing the total volume of the venous compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:BFO_0000141 a rdfs:Class ;
rdfs:label "immaterial entity"@en ;
rdfs:subClassOf obo:BFO_0000004 .
obo:PBPKO_00452 a rdfs:Class ;
rdfs:label "venous plasma compartment" ;
rdfs:comment "A compartment representing the plasma specifically within the venous blood." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_03063 a rdfs:Class ;
rdfs:label "plate wall thickness" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04045 a rdfs:Class ;
rdfs:label "blood flow rate to bile" ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00302 a rdfs:Class ;
rdfs:label "concentration in urine" ;
rdfs:comment "A biological matrix concentration specifically representing the total concentration of compound in the urine compartment." ;
rdfs:subClassOf obo:PBPKO_00297 .
obo:PBPKO_06023 a rdfs:Class ;
rdfs:label "unbound venous lung concentration" ;
rdfs:comment "The unbound venous concentration of compound in the lung compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_00647 a rdfs:Class ;
rdfs:label "diffusion rate skin" ;
rdfs:comment "A diffusion rate parameter representing diffusion rate of the chemical across the skin" ;
rdfs:subClassOf obo:PBPKO_00646 .
obo:PBPKO_00061 a rdfs:Class ;
rdfs:label "fraction of exposed skin" ;
rdfs:comment "A dimensionless fraction of volume defined as the exposed skin volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:OBI_0200171 a rdfs:Class ;
rdfs:label "partitioning data transformation"@en ;
rdfs:comment "A partitioning data transformation is a data transformation that has objective partitioning."@en ;
rdfs:subClassOf obo:OBI_0200000 .
obo:PBPKO_04034 a rdfs:Class ;
rdfs:label "plasma flow rate to unexposed skin" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the unexposed skin compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00530 a rdfs:Class ;
rdfs:label "blood flow rate to bone marrow" ;
rdfs:comment "A blood flow parameter specifically describing the rate to the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00432 a rdfs:Class ;
rdfs:label "particle density" ;
rdfs:comment "A biochemical/physical parameter representing the mass per unit volume of particles (e.g., of the administered compound)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06026 a rdfs:Class ;
rdfs:label "unbound venous skin concentration" ;
rdfs:comment "The unbound venous concentration of compound in the skin compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_05003 a rdfs:Class ;
rdfs:label "vapor pressure" ;
rdfs:comment "A physicochemical parameter describing the vapor pressure of the compound" ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:OBI_0000450 a rdfs:Class ;
rdfs:label "regulatory agency"@en ;
rdfs:comment "A regulatory agency is a organization that has responsibility over or for the legislation (acts and regulations) for a given sector of the government."@en ;
rdfs:subClassOf obo:OBI_0000245 .
obo:PBPKO_00050 a rdfs:Class ;
rdfs:label "blood flow rate to restbody" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the rest of body compartment (total minus specified organs)." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00274 a rdfs:Class ;
rdfs:label "cumulative amount in urine" ;
rdfs:comment "An output parameter representing the total amount of compound excreted in urine over a specific time period." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:OBI_0002356 a rdfs:Class ;
rdfs:label "performance status value specification" ;
rdfs:comment "A categorical value specification that is an assessment of a participant's performance status (general well-being and activities of daily life)."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:PBPKO_02002 a rdfs:Class ;
rdfs:label "colon compartment" ;
rdfs:comment "A compartment representing the colon" ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:BFO_0000040 a rdfs:Class ;
rdfs:label "material entity"@en ;
rdfs:comment "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ;
rdfs:subClassOf obo:BFO_0000004 .
obo:PBPKO_00233 a rdfs:Class ;
rdfs:label "biliary clearance rate" ;
rdfs:comment "A clearance rate specifically quantifying elimination via bile." ;
rdfs:subClassOf obo:PBPKO_00229 .
obo:PBPKO_00611 a rdfs:Class ;
rdfs:label "fraction of blood flow to a compartment" ;
rdfs:comment "A physiological parameter representing dimensionless fraction of cardiac output delivered to a compartment." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00272 a rdfs:Class ;
rdfs:label "amount in urine" ;
rdfs:comment "The amount of compound in the urine compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00185 a rdfs:Class ;
rdfs:label "human serum albumin" ;
rdfs:comment "A material entity representing distribution-related protein (most abundant in human plasma) that binds various compounds." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:GO_0008152 a rdfs:Class ;
rdfs:label "metabolic process" ;
rdfs:subClassOf obo:GO_0009987 .
obo:PBPKO_00251 a rdfs:Class ;
rdfs:label "ocular exposure" ;
rdfs:comment "A route of exposure via the eye." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00648 a rdfs:Class ;
rdfs:label "diffusion rate stratum corneum viable epidermis" ;
rdfs:comment "A diffusion rate skin parameter representing diffusion rate from stratum corneum to viable epidermis" ;
rdfs:subClassOf obo:PBPKO_00647 .
obo:PBPKO_00479 a rdfs:Class ;
rdfs:label "hair compartment" ;
rdfs:comment "A compartment representing hair." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00039 a rdfs:Class ;
rdfs:label "fraction of blood flow to bone" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the bone compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_06018 a rdfs:Class ;
rdfs:label "unbound venous liver concentration" ;
rdfs:comment "The unbound venous concentration of compound in the liver compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_03052 a rdfs:Class ;
rdfs:label "cell fraction of proteins" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00240 a rdfs:Class ;
rdfs:label "oral exposure" ;
rdfs:comment "A route of exposure via the mouth." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_03037 a rdfs:Class ;
rdfs:label "medium polymer partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_06063 a rdfs:Class ;
rdfs:label "amount in kidney rest tissue" ;
rdfs:comment "The amount of compound in the kidney rest tissue compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00391 a rdfs:Class ;
rdfs:label "liverfetus plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal liver to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_05001 a rdfs:Class ;
rdfs:label "molar volume" ;
rdfs:comment "A physicochemical parameter representing the volume of one mole of a molecule." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00232 a rdfs:Class ;
rdfs:label "urinary clearance rate" ;
rdfs:comment "A clearance rate specifically quantifying elimination via urine." ;
rdfs:subClassOf obo:PBPKO_00229 .
obo:PBPKO_00465 a rdfs:Class ;
rdfs:label "bone marrow compartment" ;
rdfs:comment "A compartment representing the bone marrow." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00585 a rdfs:Class ;
rdfs:label "restbody blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the rest of body compartment to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04047 a rdfs:Class ;
rdfs:label "diameter of the jejunum lumen" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00143 a rdfs:Class ;
rdfs:label "gastric emptying rate" ;
rdfs:comment "A biochemical parameter representing the rate at which the stomach empties its contents into the small intestine." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00425 a rdfs:Class ;
rdfs:label "volume of jejunum" ;
rdfs:comment "A volume parameter representing the total volume of the jejunum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00430 a rdfs:Class ;
rdfs:label "mean precipitation time" ;
rdfs:comment "A biochemical parameter representing the average time for a compound to precipitate under specific conditions (e.g., in the GI tract)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00321 a rdfs:Class ;
rdfs:label "peripheral compartment" ;
rdfs:comment "A compartment in a multi-compartment model representing tissues where compound distribution is slower compared to the central compartment." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00083 a rdfs:Class ;
rdfs:label "volume of heart" ;
rdfs:comment "A volume parameter representing the total volume of the heart compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04053 a rdfs:Class ;
rdfs:label "uptake fraction to blood" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00016 a rdfs:Class ;
rdfs:label "blood flow rate to intestine" ;
rdfs:comment "A blood flow parameter specifically describing the rate to the intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00005 a rdfs:Class ;
rdfs:label "perfusion limited model" ;
rdfs:comment "A physiologically based pharmacokinetic model that assumes tissue concentration reaches equilibrium rapidly and uptake/elimination is limited by blood flow rate." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00414 a rdfs:Class ;
rdfs:label "blood flow rate to duodenum" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the duodenum compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:CL_0000000 a rdfs:Class ;
rdfs:label "cell" ;
rdfs:comment "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." ;
rdfs:subClassOf obo:UBERON_0000465 .
obo:PBPKO_01504 a rdfs:Class ;
rdfs:label "bcrp" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_03005 a rdfs:Class ;
rdfs:label "intrinsic fecal excretion rate" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00580 a rdfs:Class ;
rdfs:label "mammary gland blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the mammary gland to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00227 a rdfs:Class ;
rdfs:label "sweat excretion" ;
rdfs:comment "An excretion process involving the elimination of compounds and metabolites through sweat." ;
rdfs:subClassOf obo:GO_0007588 .
obo:PBPKO_00216 a rdfs:Class ;
rdfs:label "dissociation constant" ;
rdfs:comment "A biochemical parameter (Kd) measuring the affinity of a compound for its binding partner (e.g., receptor, protein)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00283 a rdfs:Class ;
rdfs:label "percentile 97.5 cplasma" ;
rdfs:comment "A plasma concentration parameter representing the 97.5th percentile of the plasma concentration distribution in a population simulation." ;
rdfs:subClassOf obo:PBPKO_00549 .
obo:PBPKO_00637 a rdfs:Class ;
rdfs:label "amount in viable epidermis of unexposed skin" ;
rdfs:comment "The amount of chemical in viable epidermis of unexposed skin" ;
rdfs:subClassOf obo:PBPKO_00506 .
obo:PBPKO_00002 a rdfs:Class ;
rdfs:label "parameter" ;
rdfs:comment "A data item involved in PBPK modelling." ;
rdfs:subClassOf obo:IAO_0000027 .
obo:PBPKO_04081 a rdfs:Class ;
rdfs:label "volume of alveolar compartment" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06002 a rdfs:Class ;
rdfs:label "unbound venous concentration of compound in compartment" ;
rdfs:subClassOf obo:PBPKO_06003 .
obo:PBPKO_02005 a rdfs:Class ;
rdfs:label "portal vein perfused tissue comparment" ;
rdfs:comment "A compartment with grouped organs that are exclusively perfused via the portal vein (i.e.: Stomach, small and large intestine, spleen)" ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:IAO_0000100 a rdfs:Class ;
rdfs:label "homogenous data collection"@en ;
rdfs:comment "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets."@en ;
rdfs:subClassOf obo:IAO_0001000 .
obo:PBPKO_00262 a rdfs:Class ;
rdfs:label "half-life" ;
rdfs:comment "An output parameter representing the time required for the compound concentration to decrease by half (t1/2)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00622 a rdfs:Class ;
rdfs:label "fraction unbound blood" ;
rdfs:comment "An unbound fraction parameter specifically for the blood compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00493 a rdfs:Class ;
rdfs:label "stratum corneum compartment" ;
rdfs:comment "A skin compartment representing the stratum corneum layer." ;
rdfs:subClassOf obo:PBPKO_00470 .
obo:PBPKO_00132 a rdfs:Class ;
rdfs:label "water solubility" ;
rdfs:comment "A physicochemical parameter representing the solubility of a compound specifically in water." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:OBI_0000658 a rdfs:Class ;
rdfs:label "data representational model" ;
rdfs:comment "An information content entity representing the relationships between data items."@en ;
rdfs:subClassOf obo:IAO_0000033 .
obo:PBPKO_00310 a rdfs:Class ;
rdfs:label "influx constant" ;
rdfs:comment "A biochemical parameter (kin) describing the rate constant for compound movement into a cell or compartment." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_03031 a rdfs:Class ;
rdfs:label "follicle permeability coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:BFO_0000023 a rdfs:Class ;
rdfs:label "role"@en ;
rdfs:comment "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts."@en ;
rdfs:subClassOf obo:BFO_0000017 .
obo:PBPKO_00243 a rdfs:Class ;
rdfs:label "intravenous bolus exposure" ;
rdfs:comment "A route of exposure involving rapid injection directly into a vein." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00114 a rdfs:Class ;
rdfs:label "fraction alveolar volume" ;
rdfs:comment "A dimensionless fraction of volume defined as the alveolar volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00109 a rdfs:Class ;
rdfs:label "volume of exposed skin" ;
rdfs:comment "A volume parameter representing the total volume of the exposed skin compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00441 a rdfs:Class ;
rdfs:label "blood milk barrier compartment" ;
rdfs:comment "A barrier compartment representing the physiological barrier separating blood and milk in lactating species." ;
rdfs:subClassOf obo:PBPKO_00495 .
obo:PBPKO_00072 a rdfs:Class ;
rdfs:label "fraction of small intestine" ;
rdfs:comment "A dimensionless fraction of volume defined as the small intestine volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00645 a rdfs:Class ;
rdfs:label "fat blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in fat to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00374 a rdfs:Class ;
rdfs:label "volume of placenta" ;
rdfs:comment "A volume parameter representing the total volume of the placental compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:IAO_0000180 a rdfs:Class ;
rdfs:label "heatmap"@en ;
rdfs:comment """A heatmap is a report graph which is a graphical representation of data
where the values taken by a variable(s) are shown as colors in a
two-dimensional map."""@en ;
rdfs:subClassOf obo:IAO_0000038 .
obo:PBPKO_04020 a rdfs:Class ;
rdfs:label "plasma flow rate to restbody" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the rest of the body compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_04042 a rdfs:Class ;
rdfs:label "volume of bile" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00363 a rdfs:Class ;
rdfs:label "hippocampus brain partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the hippocampus to the overall brain." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00339 a rdfs:Class ;
rdfs:label "adult lifestage" ;
rdfs:comment "A lifestage parameter representing individuals typically from eighteen to thirty years old." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_03048 a rdfs:Class ;
rdfs:label "maximum metabolic rate" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00615 a rdfs:Class ;
rdfs:label "amount of compound in compartment" ;
rdfs:comment "An output parameter representing the amount of chemical specifically in the compartment" ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:GO_0008150 a rdfs:Class ;
rdfs:label "biological_process" ;
rdfs:comment "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:PBPKO_00120 a rdfs:Class ;
rdfs:label "fraction of lymph" ;
rdfs:comment "A dimensionless fraction of volume defined as the lymph volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00089 a rdfs:Class ;
rdfs:label "volume of skin" ;
rdfs:comment "A volume parameter representing the total volume of the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00589 a rdfs:Class ;
rdfs:label "spleen blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the spleen to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04092 a rdfs:Class ;
rdfs:label "fraction of uterus" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00475 a rdfs:Class ;
rdfs:label "epidermis compartment" ;
rdfs:comment "A skin compartment representing the epidermis layer." ;
rdfs:subClassOf obo:PBPKO_00470 .
obo:PBPKO_00377 a rdfs:Class ;
rdfs:label "volume of brain fetus" ;
rdfs:comment "A volume parameter representing the total volume of the fetal brain compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00168 a rdfs:Class ;
rdfs:label "intestine plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in intestine to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00400 a rdfs:Class ;
rdfs:label "distal tubule compartment" ;
rdfs:comment "A kidney compartment representing the distal tubule of the nephron." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_00588 a rdfs:Class ;
rdfs:label "skin blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the skin to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00336 a rdfs:Class ;
rdfs:label "child lifestage" ;
rdfs:comment "A lifestage parameter representing individuals typically between 3 and 11 years old." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:GO_0003674 a rdfs:Class ;
rdfs:label "molecular_function" ;
rdfs:comment "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:PBPKO_00020 a rdfs:Class ;
rdfs:label "blood flow rate to large intestine" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the large intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00548 a rdfs:Class ;
rdfs:label "concentration in restbody" ;
rdfs:comment "The total concentration of compound in the rest of body compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00574 a rdfs:Class ;
rdfs:label "intestine blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the intestine to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_06060 a rdfs:Class ;
rdfs:label "concentration in polymer" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00157 a rdfs:Class ;
rdfs:label "fraction unbound heart" ;
rdfs:comment "An unbound fraction parameter specifically for the heart compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00174 a rdfs:Class ;
rdfs:label "fat plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in fat (adipose tissue) to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00297 a rdfs:Class ;
rdfs:label "biological matrix concentration" ;
rdfs:comment "An output parameter representing the total concentration of a compound in a specified biological matrix." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00040 a rdfs:Class ;
rdfs:label "blood flow rate to brain" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the brain compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00388 a rdfs:Class ;
rdfs:label "gestational week" ;
rdfs:comment "A physiological parameter representing the specific week of gestation." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:BFO_0000016 a rdfs:Class ;
rdfs:label "disposition"@en ;
rdfs:subClassOf obo:BFO_0000017 .
obo:OBI_0000704 a rdfs:Class ;
rdfs:label "decision tree induction objective" ;
rdfs:comment "A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made."@en ;
rdfs:subClassOf obo:OBI_0200166 .
obo:PBPKO_00644 a rdfs:Class ;
rdfs:label "thickness viable epidermis" ;
rdfs:comment "A skin thickness parameter representing the thickness of viable epidermis." ;
rdfs:subClassOf obo:PBPKO_00635 .
obo:PBPKO_04085 a rdfs:Class ;
rdfs:label "fraction of thyroid" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00258 a rdfs:Class ;
rdfs:label "area under curve last" ;
rdfs:comment "An area under curve parameter calculated from time zero to the time of the last measurable concentration (AUClast)." ;
rdfs:subClassOf obo:PBPKO_00256 .
obo:PBPKO_03020 a rdfs:Class ;
rdfs:label "intrinsic enterohepatic recirculation rate constant" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00481 a rdfs:Class ;
rdfs:label "ileum compartment" ;
rdfs:comment "A small intestine compartment representing the ileum." ;
rdfs:subClassOf obo:PBPKO_00472 .
obo:PBPKO_04075 a rdfs:Class ;
rdfs:label "volume of skeleton" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04103 a rdfs:Class ;
rdfs:label "fraction of adipose mass" ;
rdfs:comment "A dimensionless fraction of volume defined as the adipose mass volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00626 a rdfs:Class ;
rdfs:label "unexposed skin compartment" ;
rdfs:comment "A skin compartment representing the unexposed part of the skin to the chemical such as regions covered by clothing or occluded areas like the inner arms." ;
rdfs:subClassOf obo:PBPKO_00470 .
obo:PBPKO_00347 a rdfs:Class ;
rdfs:label "brain pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model specifically built to predict compound concentrations in the brain." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_03026 a rdfs:Class ;
rdfs:label "half-saturation concentration of chemical for binding by sites in red cells" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06013 a rdfs:Class ;
rdfs:label "amount in spleen" ;
rdfs:comment "The amount of chemical in spleen compartment" ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_06066 a rdfs:Class ;
rdfs:label "amount in kidney proximal tubule lumen" ;
rdfs:comment "The amount of compound in the proximal tubule lumen of kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_04074 a rdfs:Class ;
rdfs:label "volume of uterus" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04069 a rdfs:Class ;
rdfs:label "volume of small intestinal lumen" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00633 a rdfs:Class ;
rdfs:label "amount in alveolar air" ;
rdfs:comment "The amount of compound in the alveolar air compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00078 a rdfs:Class ;
rdfs:label "fraction of liver" ;
rdfs:comment "A dimensionless fraction of volume defined as the liver volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00399 a rdfs:Class ;
rdfs:label "loop of Henle compartment" ;
rdfs:comment "A kidney compartment representing the loop of Henle within the nephron." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_04108 a rdfs:Class ;
rdfs:label "volume of kidney proximal tubule tissue" ;
rdfs:comment "A volume parameter representing the total volume of the tissue of kidney proximal tubule compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:UBERON_0000477 a rdfs:Class ;
rdfs:label "anatomical cluster" ;
rdfs:comment "Anatomical group whose component anatomical structures lie in close proximity to each other." ;
rdfs:subClassOf obo:UBERON_0000465 .
obo:PBPKO_00470 a rdfs:Class ;
rdfs:label "skin compartment" ;
rdfs:comment "A compartment representing the skin." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00577 a rdfs:Class ;
rdfs:label "liver blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the liver to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:IAO_0000030 a rdfs:Class ;
rdfs:label "information content entity"@en ;
rdfs:comment "A generically dependent continuant that is about some thing."@en ;
rdfs:subClassOf obo:BFO_0000031 .
obo:PBPKO_00090 a rdfs:Class ;
rdfs:label "fraction of skin" ;
rdfs:comment "A dimensionless fraction of volume defined as the skin volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00352 a rdfs:Class ;
rdfs:label "spinal cerebrospinal fluid flow rate" ;
rdfs:comment "A bodily fluid flow rate parameter representing the flow rate of cerebrospinal fluid (CSF) compartment in the spinal region." ;
rdfs:subClassOf obo:PBPKO_00636 .
obo:UBERON_0000466 a rdfs:Class ;
rdfs:label "immaterial anatomical entity" ;
rdfs:comment "Anatomical entity that has no mass." ;
rdfs:subClassOf obo:BFO_0000141 , obo:UBERON_0001062 .
obo:PBPKO_00537 a rdfs:Class ;
rdfs:label "octanol air partition coefficient" ;
rdfs:comment "A partition coefficient (Koa) representing the ratio of compound concentration in octanol to air at equilibrium." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00578 a rdfs:Class ;
rdfs:label "liverfetus blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal liver to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00066 a rdfs:Class ;
rdfs:label "volume of compartment" ;
rdfs:comment "A physiological parameter representing the volume of a specific organ or tissue." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_04064 a rdfs:Class ;
rdfs:label "volume of serum" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00385 a rdfs:Class ;
rdfs:label "blood flow rate to brain fetus" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the fetal brain compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:NCBITaxon_7742 a rdfs:Class ;
rdfs:label "Vertebrata " ;
rdfs:subClassOf obo:NCBITaxon_33213 .
obo:PBPKO_04018 a rdfs:Class ;
rdfs:label "plasma flow rate to poorly perfused" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the poorly perfused compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_03015 a rdfs:Class ;
rdfs:label "kinetic emptying rate between intestinal segments" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00497 a rdfs:Class ;
rdfs:label "amount in liver" ;
rdfs:comment "The amount of compound in the liver compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00269 a rdfs:Class ;
rdfs:label "elimination phase" ;
rdfs:comment "An elimination process phase describing the period where removal of the compound from the body predominates." ;
rdfs:subClassOf obo:PBPKO_00322 .
obo:PBPKO_00486 a rdfs:Class ;
rdfs:label "pancreas compartment" ;
rdfs:comment "A compartment representing the pancreas." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00209 a rdfs:Class ;
rdfs:label "phase III" ;
rdfs:comment "A metabolism/transport process involving the further processing and excretion of conjugated metabolites (often involving efflux transporters)." ;
rdfs:subClassOf obo:GO_0008152 .
obo:PBPKO_06035 a rdfs:Class ;
rdfs:label "total venous lung concentration" ;
rdfs:comment "The total venous concentration of compound in the lung compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00247 a rdfs:Class ;
rdfs:label "intrathecal exposure" ;
rdfs:comment "A route of exposure involving administration into the spinal canal." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:NCBITaxon_9606 a rdfs:Class ;
rdfs:label "Homo sapiens" ;
rdfs:subClassOf obo:NCBITaxon_314146 .
obo:PBPKO_00287 a rdfs:Class ;
rdfs:label "biomonitoring equivalent" ;
rdfs:comment "An output parameter representing the concentration of a chemical (or metabolite) in a biological medium consistent with exposure guidance values (BE)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00153 a rdfs:Class ;
rdfs:label "fraction unbound pancreas" ;
rdfs:comment "An unbound fraction parameter specifically for the pancreas compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:COB_0000082 a rdfs:Class ;
rdfs:label "planned process"@en ;
rdfs:comment "A process that is initiated by an agent who intends to carry out a plan to achieve an objective through one or more actions as described in a plan specification."@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:IAO_0000184 a rdfs:Class ;
rdfs:label "scatter plot"@en ;
rdfs:comment "A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis."@en ;
rdfs:subClassOf obo:IAO_0000038 .
obo:PBPKO_00433 a rdfs:Class ;
rdfs:label "particle radius" ;
rdfs:comment "A biochemical/physical parameter representing the radius of particles (e.g., of the administered compound)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06024 a rdfs:Class ;
rdfs:label "unbound venous fat concentration" ;
rdfs:comment "The unbound venous concentration of compound in the fat compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_00183 a rdfs:Class ;
rdfs:label "air plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in air to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00056 a rdfs:Class ;
rdfs:label "blood flow rate to lymph" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the lymph compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00471 a rdfs:Class ;
rdfs:label "duodenum compartment" ;
rdfs:comment "A small intestine compartment representing the duodenum." ;
rdfs:subClassOf obo:PBPKO_00472 .
obo:PBPKO_00024 a rdfs:Class ;
rdfs:label "blood flow rate to liver" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the liver compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00335 a rdfs:Class ;
rdfs:label "toddler lifestage" ;
rdfs:comment "A lifestage parameter representing a young child, typically between one and three years old." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_06053 a rdfs:Class ;
rdfs:label "amount in follicles" ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:BFO_0000001 a rdfs:Class ;
rdfs:label "entity"@en .
obo:PBPKO_00063 a rdfs:Class ;
rdfs:label "arterial blood flow rate" ;
rdfs:comment "A blood flow rate parameter representing the rate of blood flow through the arterial compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00164 a rdfs:Class ;
rdfs:label "fraction unbound enterocytes" ;
rdfs:comment "An unbound fraction parameter specifically within enterocytes." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00504 a rdfs:Class ;
rdfs:label "amount in lung" ;
rdfs:comment "The amount of compound in the lung compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:OBI_0000017 a rdfs:Class ;
rdfs:label "regulatory role"@en ;
rdfs:comment "a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body."@en ;
rdfs:subClassOf obo:BFO_0000023 .
obo:OBI_0000260 a rdfs:Class ;
rdfs:label "plan"@en ;
rdfs:comment "A plan is a realizable entity that is the inheres in a bearer who is committed to realizing it as a completely executed planned process."@en ;
rdfs:subClassOf obo:BFO_0000017 .
obo:RO_0000059 a rdf:Property ;
rdfs:label "concretizes"@en ;
rdfs:comment "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ;
rdfs:range .
obo:PBPKO_04100 a rdfs:Class ;
rdfs:label "fraction of blood" ;
rdfs:comment "A dimensionless fraction of volume defined as the blood volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00436 a rdfs:Class ;
rdfs:label "milk plasma ratio" ;
rdfs:comment "A biochemical parameter representing the ratio of compound concentration in milk to plasma." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00178 a rdfs:Class ;
rdfs:label "spleen plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in spleen to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00650 a rdfs:Class ;
rdfs:label "Michaelis" ;
rdfs:comment "A flag indicating for Michaelis-Menten or linear metabolism equation being used in the model" ;
rdfs:subClassOf obo:PBPKO_00649 .
obo:PBPKO_00118 a rdfs:Class ;
rdfs:label "fraction of portal vein" ;
rdfs:comment "A dimensionless fraction of volume defined as the portal vein volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00259 a rdfs:Class ;
rdfs:label "area under curve 0 to infinity" ;
rdfs:comment "An area under curve parameter extrapolated from time zero to infinity (AUC0-inf), representing total exposure after a single dose." ;
rdfs:subClassOf obo:PBPKO_00256 .
obo:PBPKO_00515 a rdfs:Class ;
rdfs:label "brain plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the brain to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04089 a rdfs:Class ;
rdfs:label "fraction of stomach lumen" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_03059 a rdfs:Class ;
rdfs:label "fraction of albumin in the FBS" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00277 a rdfs:Class ;
rdfs:label "steady state area under curve" ;
rdfs:comment "An area under curve parameter calculated over a dosing interval at steady state (AUCss)." ;
rdfs:subClassOf obo:PBPKO_00256 .
obo:PBPKO_00094 a rdfs:Class ;
rdfs:label "fraction of brain" ;
rdfs:comment "A dimensionless fraction of volume defined as the brain volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00643 a rdfs:Class ;
rdfs:label "thickness stratum corneum" ;
rdfs:comment "A skin thickness parameter representing the thickness of stratum corneum." ;
rdfs:subClassOf obo:PBPKO_00635 .
obo:PBPKO_00355 a rdfs:Class ;
rdfs:label "volume of hippocampus" ;
rdfs:comment "A volume parameter representing the total volume of the hippocampus compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00553 a rdfs:Class ;
rdfs:label "digestive system compartment" ;
rdfs:comment "A compartment representing the digestive system or parts thereof." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_03019 a rdfs:Class ;
rdfs:label "absorption rate of metabolite" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04095 a rdfs:Class ;
rdfs:label "fraction of amniotic fluid" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00067 a rdfs:Class ;
rdfs:label "volume of stomach" ;
rdfs:comment "A volume parameter representing the total volume of the stomach compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:OBI_0200188 a rdfs:Class ;
rdfs:label "cross validation objective"@en ;
rdfs:comment "A cross validation objective is a data transformation objective in which the aim is to partition a sample of data into subsets such that the analysis is initially performed on a single subset, while the other subset(s) are retained for subsequent use in confirming and validating the initial analysis."@en ;
rdfs:subClassOf obo:OBI_0200172 .
obo:PBPKO_04031 a rdfs:Class ;
rdfs:label "plasma flow rate to gut" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the gut compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00249 a rdfs:Class ;
rdfs:label "nasal exposure" ;
rdfs:comment "A route of exposure via the nasal passages." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00254 a rdfs:Class ;
rdfs:label "maximum steady state concentration" ;
rdfs:comment "An output parameter representing the maximum concentration (Cmax,ss) achieved at steady state during repeated dosing." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00396 a rdfs:Class ;
rdfs:label "Bowman's capsule compartment" ;
rdfs:comment "A kidney compartment representing the Bowman's capsule." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_00632 a rdfs:Class ;
rdfs:label "amount in venous blood" ;
rdfs:comment "The amount of compound in the venous blood compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00172 a rdfs:Class ;
rdfs:label "muscle plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in muscle to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00131 a rdfs:Class ;
rdfs:label "logarithmic solubility" ;
rdfs:comment "A physicochemical parameter representing the 10-based logarithm of a compound's solubility (typically in mol/L)." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:GO_0003008 a rdfs:Class ;
rdfs:label "system process" ;
rdfs:subClassOf obo:GO_0032501 .
obo:PBPKO_00045 a rdfs:Class ;
rdfs:label "fraction of blood flow to lung" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the lung compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:OBI_0002989 a rdfs:Class ;
rdfs:label "material supplier" ;
rdfs:comment "A person or organization that provides material supplies to other people or organizations."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00034 a rdfs:Class ;
rdfs:label "blood flow rate to gonad" ;
rdfs:comment "A blood flow parameter specifically describing the rate to the gonads compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_04014 a rdfs:Class ;
rdfs:label "plasma flow rate to bone" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the bone compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_04084 a rdfs:Class ;
rdfs:label "fraction of breast" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:OBI_0001479 a rdfs:Class ;
rdfs:label "specimen from organism" ;
rdfs:comment "A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm)."@en ;
rdfs:subClassOf obo:OBI_0100051 .
obo:PBPKO_04111 a rdfs:Class ;
rdfs:label "volume of intestine tissue" ;
rdfs:comment "A volume parameter representing the total volume of the tissue of intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:BFO_0000004 a rdfs:Class ;
rdfs:label "independent continuant"@en ;
rdfs:comment "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
rdfs:subClassOf obo:BFO_0000002 .
obo:PBPKO_06056 a rdfs:Class ;
rdfs:label "concentration in mitochondria" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:BFO_0000015 a rdfs:Class ;
rdfs:label "process"@en ;
rdfs:comment "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
rdfs:subClassOf obo:BFO_0000003 .
obo:PBPKO_00265 a rdfs:Class ;
rdfs:label "mean absorption time" ;
rdfs:comment "An output parameter representing the average time for a compound to be absorbed into systemic circulation (MAT)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00482 a rdfs:Class ;
rdfs:label "jejunum compartment" ;
rdfs:comment "A small intestine compartment representing the jejunum." ;
rdfs:subClassOf obo:PBPKO_00472 .
obo:PBPKO_00238 a rdfs:Class ;
rdfs:label "biliary elimination" ;
rdfs:comment "An elimination process involving the irreversible transfer of compound or metabolites from plasma to bile via hepatocytes." ;
rdfs:subClassOf obo:PBPKO_00322 .
obo:PBPKO_00526 a rdfs:Class ;
rdfs:label "volume of mass balance" ;
rdfs:comment "A volume parameter representing the check for total mass balance of all compartments (sum of organ volumes should equal body volume/weight equivalent, depending on units)." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04104 a rdfs:Class ;
rdfs:label "fraction of intestinal tissue" ;
rdfs:comment "A dimensionless fraction of volume defined as the intestinal tissue volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00129 a rdfs:Class ;
rdfs:label "distribution coefficient" ;
rdfs:comment "A physicochemical parameter representing the logarithm of the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium, specifically describing lipophilicity (LogD)." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_04025 a rdfs:Class ;
rdfs:label "plasma flow rate to jejunum" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the jejunum compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:NCBITaxon_33154 a rdfs:Class ;
rdfs:label "Opisthokonta" ;
rdfs:subClassOf obo:NCBITaxon_2759 .
obo:PBPKO_00013 a rdfs:Class ;
rdfs:label "cardiac output rate" ;
rdfs:comment "A blood flow rate parameter representing the volume of blood pumped by the heart compartment per unit of time." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_03040 a rdfs:Class ;
rdfs:label "medium lysosomes partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00147 a rdfs:Class ;
rdfs:label "volume of distribution" ;
rdfs:comment "A biochemical parameter representing the apparent volume into which a compound distributes in the body relative to its plasma concentration." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00422 a rdfs:Class ;
rdfs:label "fraction of colon" ;
rdfs:comment "A dimensionless fraction of volume defined as the colon volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:CHEBI_33252 a rdfs:Class ;
rdfs:label "atomic nucleus" ;
rdfs:comment "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." ;
rdfs:subClassOf obo:CHEBI_36342 .
obo:PBPKO_00581 a rdfs:Class ;
rdfs:label "milk blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in milk to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00028 a rdfs:Class ;
rdfs:label "blood flow rate to muscle" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the muscle compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00052 a rdfs:Class ;
rdfs:label "blood flow rate to gall bladder" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the gall bladder compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:OBI_0001930 a rdfs:Class ;
rdfs:label "categorical value specification" ;
rdfs:comment "A value specification that is specifies one category out of a fixed number of nominal categories"@en ;
rdfs:subClassOf obo:OBI_0001933 .
obo:PBPKO_00284 a rdfs:Class ;
rdfs:label "tolerable daily intake" ;
rdfs:comment "An output parameter (or exposure limit) estimating the amount of a substance that can be ingested daily over a lifetime without appreciable health risk (TDI)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_04090 a rdfs:Class ;
rdfs:label "fraction of gut intestinal tract" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00212 a rdfs:Class ;
rdfs:label "Michaelis constant intestine" ;
rdfs:comment "Michaelis constant representing the substrate concentration at which the reaction rate in the intestine is half of Vmax (Km)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00531 a rdfs:Class ;
rdfs:label "blood flow rate to gut" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the gut compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00500 a rdfs:Class ;
rdfs:label "amount in delay" ;
rdfs:comment "The amount of compound in the hypothetical delay compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:OBI_0200166 a rdfs:Class ;
rdfs:label "data transformation objective"@en ;
rdfs:comment "An objective specification to transformation input data into output data"@en ;
rdfs:subClassOf obo:IAO_0000005 .
obo:PBPKO_00462 a rdfs:Class ;
rdfs:label "appendix compartment" ;
rdfs:comment "A large intestine compartment representing the appendix." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_00100 a rdfs:Class ;
rdfs:label "fraction of poorly perfused" ;
rdfs:comment "A dimensionless fraction of volume defined as the poorly perfused compartment volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_03053 a rdfs:Class ;
rdfs:label "cell fraction of lipids" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04003 a rdfs:Class ;
rdfs:label "plasma flow rate to intestine" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the intestine compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00559 a rdfs:Class ;
rdfs:label "lung compartment" ;
rdfs:comment "A compartment representing the lung(s)." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00492 a rdfs:Class ;
rdfs:label "spleen compartment" ;
rdfs:comment "A compartment representing the spleen." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00621 a rdfs:Class ;
rdfs:label "cerebrospinal fluid compartment" ;
rdfs:comment "A part of brain compartment representing the cerebrospinal fluid region of the brain" ;
rdfs:subClassOf obo:PBPKO_00466 .
obo:PBPKO_00542 a rdfs:Class ;
rdfs:label "concentration in filtrate" ;
rdfs:comment "The total concentration of compound in the filtrate compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00160 a rdfs:Class ;
rdfs:label "fraction unbound skin" ;
rdfs:comment "An unbound fraction parameter specifically for the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_03051 a rdfs:Class ;
rdfs:label "cell replication time" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00060 a rdfs:Class ;
rdfs:label "fraction of blood flow to stratum corneum" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the stratum corneum compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:COB_0000502 a rdfs:Class ;
rdfs:label "characteristic"@en .
obo:PBPKO_00454 a rdfs:Class ;
rdfs:label "poorly perfused tissue compartment" ;
rdfs:comment "A compartment representing lumped tissues with low blood flow relative to their volume." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00027 a rdfs:Class ;
rdfs:label "fraction of blood flow to kidney" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_04036 a rdfs:Class ;
rdfs:label "plasma flow rate to skin stratum corneum unexposed" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the unexposed stratum corneum compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_06029 a rdfs:Class ;
rdfs:label "total venous concentration of compound in compartment" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_03041 a rdfs:Class ;
rdfs:label "medium intracellular water partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00273 a rdfs:Class ;
rdfs:label "amount in feces" ;
rdfs:comment "The amount of compound in the feces compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00489 a rdfs:Class ;
rdfs:label "rectum compartment" ;
rdfs:comment "A large intestine compartment representing the rectum." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_04019 a rdfs:Class ;
rdfs:label "plasma flow rate to richly perfused" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the richly perfused compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00342 a rdfs:Class ;
rdfs:label "pediatric lifestage" ;
rdfs:comment "A lifestage parameter representing individuals typically below fifteen years of age." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_00038 a rdfs:Class ;
rdfs:label "blood flow rate to bone" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the bone compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:IAO_0000104 a rdfs:Class ;
rdfs:label "plan specification"@en ;
rdfs:comment "A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified."@en ;
rdfs:subClassOf obo:IAO_0000033 .
obo:PBPKO_00451 a rdfs:Class ;
rdfs:label "arterial plasma" ;
rdfs:comment "A compartment representing the plasma specifically within the arterial blood." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00261 a rdfs:Class ;
rdfs:label "mean residence time" ;
rdfs:comment "An output parameter representing the average time a compound resides in the body (MRT)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00136 a rdfs:Class ;
rdfs:label "hydrogen acceptor count" ;
rdfs:comment "A physicochemical parameter representing the integer number of hydrogen bond acceptors in a molecular entity." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00006 a rdfs:Class ;
rdfs:label "physiological parameter" ;
rdfs:comment "A parameter that provides the structural framework for a PBPK model and relates to the organism's physiology (e.g., body weight, organ volume, blood flow)." ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:PBPKO_04008 a rdfs:Class ;
rdfs:label "plasma flow rate to kidney" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00403 a rdfs:Class ;
rdfs:label "lung pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model specifically built to predict compound concentrations within the lung compartments." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00017 a rdfs:Class ;
rdfs:label "fraction of blood flow to intestine" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_03012 a rdfs:Class ;
rdfs:label "kinetic absorption rate from large intestinal lumen to intestinal tissue" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00366 a rdfs:Class ;
rdfs:label "frontalcortex brain partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the frontal cortex to the overall brain." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00049 a rdfs:Class ;
rdfs:label "fraction of blood flow to richly perfused" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the richly perfused compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00223 a rdfs:Class ;
rdfs:label "renal excretion" ;
rdfs:comment "An excretion process involving the elimination of compounds and metabolites primarily through urine via the kidneys." ;
rdfs:subClassOf obo:GO_0007588 .
obo:PBPKO_03001 a rdfs:Class ;
rdfs:label "intrinsic gastric emptying rate" ;
rdfs:comment "The absorption rate constant parameter representing the intrinsic rate of the chemical release from stomach to lumen or the jejunum segment" ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:PBPKO_00564 a rdfs:Class ;
rdfs:label "blood flow rate to skin stratum corneum unexposed" ;
rdfs:comment "A blood flow rate to skin parameter specifically describing the rate to the unexposed stratum corneum compartment." ;
rdfs:subClassOf obo:PBPKO_00036 .
obo:PBPKO_06046 a rdfs:Class ;
rdfs:label "concentration in intestinal tissue" ;
rdfs:comment "The concentration of chemical in tissue of intestine." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00250 a rdfs:Class ;
rdfs:label "transdermal exposure" ;
rdfs:comment "A route of exposure involving absorption through the skin, typically from a patch." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00478 a rdfs:Class ;
rdfs:label "gut lumen compartment" ;
rdfs:comment "A digestive system compartment representing the lumen (opening) within the gut." ;
rdfs:subClassOf obo:PBPKO_00553 .
obo:PBPKO_00411 a rdfs:Class ;
rdfs:label "fraction of blood flow to ileum" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the ileum compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00570 a rdfs:Class ;
rdfs:label "brainfetus blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal brain to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04058 a rdfs:Class ;
rdfs:label "volume fraction of red blood cells" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00518 a rdfs:Class ;
rdfs:label "restbody plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the rest of body compartment to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00096 a rdfs:Class ;
rdfs:label "fraction of spleen" ;
rdfs:comment "A dimensionless fraction of volume defined as the spleen volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00105 a rdfs:Class ;
rdfs:label "volume of rest body" ;
rdfs:comment "A volume parameter representing the total volume of the rest of body compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00280 a rdfs:Class ;
rdfs:label "max organ concentration" ;
rdfs:comment "An output parameter representing the maximum concentration of a compound in a specific organ after exposure." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00311 a rdfs:Class ;
rdfs:label "efflux rate constant" ;
rdfs:comment "A biochemical parameter (kefflux) describing the rate constant for compound movement out of a cell or compartment." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:GO_0007588 a rdfs:Class ;
rdfs:label "excretion" ;
rdfs:subClassOf obo:GO_0003008 .
obo:IAO_0000033 a rdfs:Class ;
rdfs:label "directive information entity"@en ;
rdfs:comment "An information content entity whose concretizations indicate to their bearer how to realize them in a process."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PBPKO_00499 a rdfs:Class ;
rdfs:label "amount in filtrate" ;
rdfs:comment "The amount of compound in the filtrate compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00071 a rdfs:Class ;
rdfs:label "volume of small intestine" ;
rdfs:comment "A volume parameter representing the total volume of the small intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00023 a rdfs:Class ;
rdfs:label "fraction of blood flow to pancreas" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the pancreas compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00373 a rdfs:Class ;
rdfs:label "volume of fetus" ;
rdfs:comment "A volume parameter representing the total volume of the fetus." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_03066 a rdfs:Class ;
rdfs:label "FBS pH" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00322 a rdfs:Class ;
rdfs:label "elimination" ;
rdfs:comment "A biological process involving the irreversible removal of a compound from the body, encompassing metabolism and excretion." ;
rdfs:subClassOf obo:GO_0008150 .
obo:PBPKO_00175 a rdfs:Class ;
rdfs:label "gonad plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in gonads to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00649 a rdfs:Class ;
rdfs:label "miscellaneous parameter" ;
rdfs:comment "A parameter being used in the model but does not belong to specific parameter subclass" ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:PBPKO_00558 a rdfs:Class ;
rdfs:label "liver compartment" ;
rdfs:comment "A compartment representing the liver." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:BFO_0000002 a rdfs:Class ;
rdfs:label "continuant"@en ;
rdfs:comment "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ;
rdfs:subClassOf obo:BFO_0000001 .
obo:PBPKO_05002 a rdfs:Class ;
rdfs:label "Henry's law constant" ;
rdfs:comment "A physicochemical parameter describing the volatily of a compound" ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00004 a rdfs:Class ;
rdfs:label "whole body pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model that contains an explicit representation of the organs most relevant to the ADME of the compound." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00413 a rdfs:Class ;
rdfs:label "fraction of blood flow to cecum" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the cecum compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00635 a rdfs:Class ;
rdfs:label "skin thickness" ;
rdfs:comment "A physiological parameter representing the thickness of the skin compartment" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_06025 a rdfs:Class ;
rdfs:label "unbound venous bone marrow concentration" ;
rdfs:comment "The unbound venous concentration of compound in the bone marrow compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_00113 a rdfs:Class ;
rdfs:label "volume of unexposed stratum corneum" ;
rdfs:comment "A volume parameter representing the total volume of the unexposed stratum corneum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04046 a rdfs:Class ;
rdfs:label "diameter of intestinal" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_02004 a rdfs:Class ;
rdfs:label "intestinal tissue compartment" ;
rdfs:comment "A compartment representing the whole intestinal tissue" ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:OBI_0000700 a rdfs:Class ;
rdfs:label "support vector machine" ;
rdfs:comment "A support vector machine is a data transformation with a class prediction objective based on the construction of a separating hyperplane that maximizes the margin between two data sets of vectors in n-dimensional space."@en ;
rdfs:subClassOf obo:OBI_0000663 .
obo:PBPKO_03023 a rdfs:Class ;
rdfs:label "intrinsic reabsorption rate constant" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00384 a rdfs:Class ;
rdfs:label "blood flow rate to kidneyfetus" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the fetal kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00424 a rdfs:Class ;
rdfs:label "volume of duodenum" ;
rdfs:comment "A volume parameter representing the total volume of the duodenum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00082 a rdfs:Class ;
rdfs:label "fraction of muscle" ;
rdfs:comment "A dimensionless fraction of volume defined as the muscle volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_03072 a rdfs:Class ;
rdfs:label "fraction unbound in the medium" ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_04071 a rdfs:Class ;
rdfs:label "volume of stomach lumen" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04054 a rdfs:Class ;
rdfs:label "fraction of bile in small intestine" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_04060 a rdfs:Class ;
rdfs:label "thickness epidermis" ;
rdfs:subClassOf obo:PBPKO_00635 .
obo:PBPKO_00074 a rdfs:Class ;
rdfs:label "fraction of large intestine" ;
rdfs:comment "A dimensionless fraction of volume defined as the large intestine volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00075 a rdfs:Class ;
rdfs:label "volume of pancreas" ;
rdfs:comment "A volume parameter representing the total volume of the pancreas compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_01503 a rdfs:Class ;
rdfs:label "mrp4" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_04039 a rdfs:Class ;
rdfs:label "blood flow rate to red blood cells" ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_06062 a rdfs:Class ;
rdfs:label "amount in menstrual" ;
rdfs:comment "The amount of compound in the menstrual compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00171 a rdfs:Class ;
rdfs:label "kidney plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in kidney to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_06036 a rdfs:Class ;
rdfs:label "total venous fat concentration" ;
rdfs:comment "The total venous concentration of compound in the fat compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00348 a rdfs:Class ;
rdfs:label "cerebrospinal fluid volume" ;
rdfs:comment "A volume parameter representing the total volume of cerebrospinal fluid (CSF) compartment in the spinal region." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:GO_0016301 a rdfs:Class ;
rdfs:label "kinase activity" ;
rdfs:subClassOf obo:GO_0003674 .
obo:IAO_0000064 a rdfs:Class ;
rdfs:label "algorithm"@en ;
rdfs:comment "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata."@en ;
rdfs:subClassOf obo:IAO_0000104 .
obo:PBPKO_03030 a rdfs:Class ;
rdfs:label "red blood cells partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_03045 a rdfs:Class ;
rdfs:label "abiotic degradation rate in medium" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04028 a rdfs:Class ;
rdfs:label "plasma flow rate to cecum" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the cecum compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00362 a rdfs:Class ;
rdfs:label "blood flow rate to cerebellum" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the cerebellum compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00616 a rdfs:Class ;
rdfs:label "concentration of compound in compartment" ;
rdfs:comment "An output parameter representing the total concentration of compound in the compartment." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00085 a rdfs:Class ;
rdfs:label "volume of fat" ;
rdfs:comment "A volume parameter representing the total volume of fat (adipose tissue) compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00646 a rdfs:Class ;
rdfs:label "diffusion rate" ;
rdfs:comment "A biochemical parameter representing the diffusion rate of the chemical" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00222 a rdfs:Class ;
rdfs:label "inhibition constant" ;
rdfs:comment "A biochemical parameter (Ki) representing the inhibition constant for a specific enzyme or transporter interaction." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_03061 a rdfs:Class ;
rdfs:label "top well diameter" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00627 a rdfs:Class ;
rdfs:label "fraction of arterial plasma volume" ;
rdfs:comment "A dimensionless fraction of volume defined as the arterial plasma volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_04065 a rdfs:Class ;
rdfs:label "volume of adrenals" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04017 a rdfs:Class ;
rdfs:label "plasma flow rate to lung" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the lung compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_04091 a rdfs:Class ;
rdfs:label "fraction of testis" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_06017 a rdfs:Class ;
rdfs:label "unbound concentration in plasma" ;
rdfs:comment "The unbound concentration of compound in the plasma compartment." ;
rdfs:subClassOf obo:PBPKO_06003 .
obo:PBPKO_00012 a rdfs:Class ;
rdfs:label "blood flow rate to compartment" ;
rdfs:comment "A bodily fluid flow rate parameter representing the rate of blood flow in different parts of the body" ;
rdfs:subClassOf obo:PBPKO_00636 .
obo:PBPKO_06039 a rdfs:Class ;
rdfs:label "total venous mammary gland concentration" ;
rdfs:comment "The total venous concentration of compound in the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00387 a rdfs:Class ;
rdfs:label "gestational age" ;
rdfs:comment "A physiological parameter representing the age of a pregnancy, typically measured in weeks." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00217 a rdfs:Class ;
rdfs:label "transporter" ;
rdfs:comment "A material entity representing protein responsible for the import or export of compounds across cell membranes." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00236 a rdfs:Class ;
rdfs:label "fecal elimination rate constant" ;
rdfs:comment "A biochemical parameter representing the rate constant for elimination via fecal excretion." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:IAO_0000101 a rdfs:Class ;
rdfs:label "image"@en ;
rdfs:comment "An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface."@en ;
rdfs:subClassOf obo:IAO_0000308 .
obo:PBPKO_00561 a rdfs:Class ;
rdfs:label "venous blood compartment" ;
rdfs:comment "A compartment representing the venous blood." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00521 a rdfs:Class ;
rdfs:label "age in PBPK model" ;
rdfs:comment "A physiological parameter representing the period of lifespan (typically in years) for which the model is simulated." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_04105 a rdfs:Class ;
rdfs:label "volume of kidney rest tissue" ;
rdfs:comment "A volume parameter representing the total volume of the kidney rest tissue compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00398 a rdfs:Class ;
rdfs:label "proximal tubule compartment" ;
rdfs:comment "A kidney compartment representing the proximal tubule of the nephron." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_00434 a rdfs:Class ;
rdfs:label "intestinal transit time" ;
rdfs:comment "A biochemical parameter representing the time required for a compound to move through the intestine." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00638 a rdfs:Class ;
rdfs:label "amount in viable epidermis of exposed skin" ;
rdfs:comment "The amount of chemical in viable epidermis of exposed skin" ;
rdfs:subClassOf obo:PBPKO_00506 .
obo:PBPKO_00268 a rdfs:Class ;
rdfs:label "absolute bioavailability" ;
rdfs:comment "A bioavailability parameter comparing the amount reaching systemic circulation after non-IV administration to the amount available after IV administration." ;
rdfs:subClassOf obo:PBPKO_00263 .
obo:PBPKO_04043 a rdfs:Class ;
rdfs:label "enterocyte volume" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06021 a rdfs:Class ;
rdfs:label "unbound venous kidney concentration" ;
rdfs:comment "The unbound venous concentration of compound in the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_00161 a rdfs:Class ;
rdfs:label "fraction unbound bone" ;
rdfs:comment "An unbound fraction parameter specifically for the bone compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00417 a rdfs:Class ;
rdfs:label "blood flow rate to colon" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the colon compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_06028 a rdfs:Class ;
rdfs:label "unbound venous rest body concentration" ;
rdfs:comment "The unbound venous concentration of compound in the rest body compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PR_000000001 a rdfs:Class ;
rdfs:label "protein" ;
rdfs:comment "An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." ;
rdfs:subClassOf obo:CHEBI_16670 , obo:PR_000018263 .
obo:PBPKO_00057 a rdfs:Class ;
rdfs:label "fraction of blood flow to lymph" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the lymph compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:IAO_0000037 a rdfs:Class ;
rdfs:label "dot plot"@en ;
rdfs:comment "A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions."@en ;
rdfs:subClassOf obo:IAO_0000038 .
obo:PBPKO_00068 a rdfs:Class ;
rdfs:label "fraction of stomach" ;
rdfs:comment "A dimensionless fraction of volume defined as the stomach volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00334 a rdfs:Class ;
rdfs:label "infant lifestage" ;
rdfs:comment "A lifestage parameter representing a very young child, typically under one year of age." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_03034 a rdfs:Class ;
rdfs:label "partition coeffcient of stratum corneum to skin surface depot" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04076 a rdfs:Class ;
rdfs:label "volume of hair" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00401 a rdfs:Class ;
rdfs:label "collecting duct compartment" ;
rdfs:comment "A kidney compartment representing the collecting duct system." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_00167 a rdfs:Class ;
rdfs:label "stomach plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in stomach to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00041 a rdfs:Class ;
rdfs:label "fraction of blood flow to brain" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the brain compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00231 a rdfs:Class ;
rdfs:label "sweat clearance rate" ;
rdfs:comment "A clearance rate specifically quantifying elimination via sweat." ;
rdfs:subClassOf obo:PBPKO_00229 .
obo:PBPKO_00579 a rdfs:Class ;
rdfs:label "lung blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the lung to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00428 a rdfs:Class ;
rdfs:label "volume of cecum" ;
rdfs:comment "A volume parameter representing the total volume of the cecum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:OBI_0000571 a rdfs:Class ;
rdfs:label "manufacturer role" ;
rdfs:comment "Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process."@en ;
rdfs:subClassOf obo:BFO_0000023 .
obo:OBI_0000014 a rdfs:Class ;
rdfs:label "regulator role"@en ;
rdfs:comment "a regulatory role involved with making and/or enforcing relevant legislation and governmental orders"@en ;
rdfs:subClassOf obo:OBI_0000017 .
obo:CHEBI_16670 a rdfs:Class ;
rdfs:label "peptide" ;
rdfs:comment "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from α-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." ;
rdfs:subClassOf obo:CHEBI_33839 .
obo:OBI_0200111 a rdfs:Class ;
rdfs:label "data visualization"@en ;
rdfs:comment "A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations."@en ;
rdfs:subClassOf obo:COB_0000035 .
obo:PBPKO_00228 a rdfs:Class ;
rdfs:label "hair excretion" ;
rdfs:comment "An excretion process involving the elimination and deposition of compounds and metabolites into hair." ;
rdfs:subClassOf obo:GO_0007588 .
obo:PBPKO_04021 a rdfs:Class ;
rdfs:label "plasma flow rate to gall bladder" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the gall bladder compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00406 a rdfs:Class ;
rdfs:label "bronchiolar compartment" ;
rdfs:comment "A lung compartment representing the bronchioles." ;
rdfs:subClassOf obo:PBPKO_00559 .
obo:PBPKO_00392 a rdfs:Class ;
rdfs:label "brainfetus plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal brain to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_06032 a rdfs:Class ;
rdfs:label "total venous kidney concentration" ;
rdfs:comment "The total venous concentration of compound in the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00536 a rdfs:Class ;
rdfs:label "resorption" ;
rdfs:comment "A biochemical parameter or process representing the resorption of a compound (e.g., tubular resorption)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00337 a rdfs:Class ;
rdfs:label "teenager lifestage" ;
rdfs:comment "A lifestage parameter representing individuals typically between eleven and fifteen years old." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_00547 a rdfs:Class ;
rdfs:label "concentration in mammary gland" ;
rdfs:comment "The total concentration of compound in the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00439 a rdfs:Class ;
rdfs:label "daily milk intake" ;
rdfs:comment "A physiological parameter representing the daily volume of milk ingested (e.g., by an infant)." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00156 a rdfs:Class ;
rdfs:label "fraction unbound muscle" ;
rdfs:comment "An unbound fraction parameter specifically for the muscle compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_01508 a rdfs:Class ;
rdfs:label "oat3" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_00030 a rdfs:Class ;
rdfs:label "blood flow rate to heart" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the heart compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_06043 a rdfs:Class ;
rdfs:label "concentration in jejunum" ;
rdfs:comment "The concentration of chemical in jejunum compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00550 a rdfs:Class ;
rdfs:label "amount in fat" ;
rdfs:comment "The amount of compound in the fat compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00298 a rdfs:Class ;
rdfs:label "concentration in hair" ;
rdfs:comment "The total concentration of compound in the hair compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00446 a rdfs:Class ;
rdfs:label "compartment" ;
rdfs:comment "A data representation model component representing a distinct physiological space (organ, tissue, fluid) where ADME processes occur." ;
rdfs:subClassOf obo:OBI_0000658 .
obo:PBPKO_03055 a rdfs:Class ;
rdfs:label "cell fraction of mitochondria" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:BFO_0000019 a rdfs:Class ;
rdfs:label "quality"@en ;
rdfs:subClassOf obo:BFO_0000020 .
obo:PBPKO_04098 a rdfs:Class ;
rdfs:label "fraction of trabecular bone" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:GO_0009987 a rdfs:Class ;
rdfs:label "cellular process" ;
rdfs:subClassOf obo:GO_0008150 .
obo:PBPKO_00142 a rdfs:Class ;
rdfs:label "absorption rate constant intestine" ;
rdfs:comment "An absorption rate constant parameter representing the movement of a compound from the intestine to systemic circulation or another compartment." ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:PBPKO_00299 a rdfs:Class ;
rdfs:label "concentration in nail" ;
rdfs:comment "A biological matrix concentration specifically representing the total concentration of compound in the nail compartment." ;
rdfs:subClassOf obo:PBPKO_00297 .
obo:PBPKO_00242 a rdfs:Class ;
rdfs:label "inhalation exposure" ;
rdfs:comment "A route of exposure via inhalation into the lungs." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00257 a rdfs:Class ;
rdfs:label "area under curve 0 to t" ;
rdfs:comment "An area under curve parameter calculated from time zero to a specific time point t (AUC0-t)." ;
rdfs:subClassOf obo:PBPKO_00256 .
obo:PBPKO_00507 a rdfs:Class ;
rdfs:label "amount in mammary gland" ;
rdfs:comment "The amount of compound in the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_03049 a rdfs:Class ;
rdfs:label "linear metabolic rate" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00376 a rdfs:Class ;
rdfs:label "volume of liver fetus" ;
rdfs:comment "A volume parameter representing the total volume of the fetal liver compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06006 a rdfs:Class ;
rdfs:label "amount in jejunum" ;
rdfs:comment "The amount of chemical in jejunum compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_03008 a rdfs:Class ;
rdfs:label "kinetic emptying rate from jejunum lumen to ileum lumen" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00634 a rdfs:Class ;
rdfs:label "red blood cell compartment" ;
rdfs:comment "A compartment representing the red blood cells of the body." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00235 a rdfs:Class ;
rdfs:label "intrinsic clearance rate" ;
rdfs:comment "A clearance rate representing the inherent ability of an organ or tissue to eliminate a compound, independent of blood flow or binding." ;
rdfs:subClassOf obo:PBPKO_00229 .
obo:PBPKO_00275 a rdfs:Class ;
rdfs:label "cumulative amount in feces" ;
rdfs:comment "An output parameter representing the total amount of compound excreted in feces over a specific time period." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00590 a rdfs:Class ;
rdfs:label "stomach blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the stomach to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04007 a rdfs:Class ;
rdfs:label "plasma flow rate to liver" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the liver compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00532 a rdfs:Class ;
rdfs:label "blood flow rate to mammary gland" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_04032 a rdfs:Class ;
rdfs:label "plasma flow rate to mammary gland" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00593 a rdfs:Class ;
rdfs:label "maximum rate of basolateral transporter" ;
rdfs:comment "Maximum rate (Vmax) of transport via a basolateral transporter." ;
rdfs:subClassOf obo:PBPKO_00613 .
obo:PBPKO_00150 a rdfs:Class ;
rdfs:label "fraction unbound gut" ;
rdfs:comment "An unbound fraction parameter specifically for the gut compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_03038 a rdfs:Class ;
rdfs:label "medium air partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00130 a rdfs:Class ;
rdfs:label "dissolution in two phase system" ;
rdfs:comment "A physicochemical parameter representing the ratio of a dissolved compound in a two-phase system (often used interchangeably with partition coefficient)." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00163 a rdfs:Class ;
rdfs:label "fraction unbound lung" ;
rdfs:comment "An unbound fraction parameter specifically for the lung compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_03067 a rdfs:Class ;
rdfs:label "initial number of cells" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00093 a rdfs:Class ;
rdfs:label "volume of brain" ;
rdfs:comment "A volume parameter representing the total volume of the brain compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00044 a rdfs:Class ;
rdfs:label "blood flow rate to lung" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the lung compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:OBI_0000018 a rdfs:Class ;
rdfs:label "material supplier role"@en ;
rdfs:comment "a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation."@en ;
rdfs:subClassOf obo:OBI_0000947 .
obo:PBPKO_04013 a rdfs:Class ;
rdfs:label "plasma flow rate to skin" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the skin compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00496 a rdfs:Class ;
rdfs:label "amount in gut" ;
rdfs:comment "The amount of compound in the gut compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_06010 a rdfs:Class ;
rdfs:label "amount in small intestine segment" ;
rdfs:comment "The amount of chemical in segment of small intestine." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00051 a rdfs:Class ;
rdfs:label "fraction of blood flow to restbody" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the rest of the body compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:NCBITaxon_32523 a rdfs:Class ;
rdfs:label "Tetrapoda" ;
rdfs:subClassOf obo:NCBITaxon_117571 .
obo:PBPKO_00619 a rdfs:Class ;
rdfs:label "cerebellum compartment" ;
rdfs:comment "A part of brain compartment representing the cerebellum region of the brain" ;
rdfs:subClassOf obo:PBPKO_00466 .
obo:PBPKO_00450 a rdfs:Class ;
rdfs:label "rest of body compartment" ;
rdfs:comment "A compartment representing the lumped remainder of the body not explicitly modeled as separate organs/tissues." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:OBI_0000707 a rdfs:Class ;
rdfs:label "decision tree building data transformation"@en ;
rdfs:comment "A decision tree building data transformation is a data transformation that has objective decision tree induction."@en ;
rdfs:subClassOf obo:OBI_0200000 .
obo:PBPKO_00264 a rdfs:Class ;
rdfs:label "relative bioavailability" ;
rdfs:comment "A bioavailability parameter comparing the rate and extent of absorption of a test compound to a reference compound." ;
rdfs:subClassOf obo:PBPKO_00263 .
obo:PBPKO_00525 a rdfs:Class ;
rdfs:label "volume of mammary gland" ;
rdfs:comment "A volume parameter representing the total volume of the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00565 a rdfs:Class ;
rdfs:label "blood flow rate to skin stratum corneum exposed" ;
rdfs:comment "A blood flow rate to skin parameter specifically describing the rate to the exposed stratum corneum compartment." ;
rdfs:subClassOf obo:PBPKO_00036 .
obo:PBPKO_00370 a rdfs:Class ;
rdfs:label "apparent permeability cortex to rest of brain" ;
rdfs:comment "Apparent permeability of a compound specifically between the cortex and the rest of the brain." ;
rdfs:subClassOf obo:PBPKO_00612 .
obo:PBPKO_00354 a rdfs:Class ;
rdfs:label "blood cerebrospinal fluid compartment" ;
rdfs:comment "A barrier compartment representing the blood-cerebrospinal fluid barrier (BCSFB)." ;
rdfs:subClassOf obo:PBPKO_00495 .
obo:PBPKO_02010 a rdfs:Class ;
rdfs:label "liver extracellular compartment" ;
rdfs:comment "A compartment representing vascular and interstitial space of the liver." ;
rdfs:subClassOf obo:PBPKO_00558 .
obo:PBPKO_00218 a rdfs:Class ;
rdfs:label "oatp" ;
rdfs:comment "A transporter family (Organic Anion Transporting Polypeptides) involved in transporting organic anions." ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_00305 a rdfs:Class ;
rdfs:label "Michaelis constant baso" ;
rdfs:comment "Michaelis constant representing the substrate concentration at half-maximal velocity (Km) for a basolateral transporter." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00435 a rdfs:Class ;
rdfs:label "lactational pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model specifically built to predict compound concentrations during lactation, including transfer into milk." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00381 a rdfs:Class ;
rdfs:label "fetoplacental blood flow rate" ;
rdfs:comment "A blood flow rate parameter representing the rate of blood flow between the fetus and the placenta compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_04068 a rdfs:Class ;
rdfs:label "volume of intestinal lumen" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00485 a rdfs:Class ;
rdfs:label "nail compartment" ;
rdfs:comment "A compartment representing nails." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00543 a rdfs:Class ;
rdfs:label "concentration in lung" ;
rdfs:comment "The total concentration of compound in the lung compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_04094 a rdfs:Class ;
rdfs:label "fraction of hair" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:BFO_0000020 a rdfs:Class ;
rdfs:label "specifically dependent continuant"@en ;
rdfs:comment "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en ;
rdfs:subClassOf obo:BFO_0000002 .
obo:PBPKO_00402 a rdfs:Class ;
rdfs:label "bladder compartment" ;
rdfs:comment "A compartment representing the urinary bladder." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00253 a rdfs:Class ;
rdfs:label "peak concentration" ;
rdfs:comment "An output parameter representing the highest concentration (Cmax) of a compound achieved after exposure." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00395 a rdfs:Class ;
rdfs:label "kidney pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model specifically built to predict compound concentrations within the kidney compartments." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00103 a rdfs:Class ;
rdfs:label "volume of plasma" ;
rdfs:comment "A volume parameter representing the total volume of plasma compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00365 a rdfs:Class ;
rdfs:label "cerebellum brain partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the cerebellum to the overall brain." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00300 a rdfs:Class ;
rdfs:label "concentration in teeth" ;
rdfs:comment "A biological matrix concentration specifically representing the total concentration of compound in the teeth compartment." ;
rdfs:subClassOf obo:PBPKO_00297 .
obo:PBPKO_00474 a rdfs:Class ;
rdfs:label "large intestine compartment" ;
rdfs:comment "A digestive system compartment representing the large intestine." ;
rdfs:subClassOf obo:PBPKO_00553 .
obo:PBPKO_00062 a rdfs:Class ;
rdfs:label "fraction of unexposed skin" ;
rdfs:comment "A dimensionless fraction of volume defined as the unexposed skin volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00179 a rdfs:Class ;
rdfs:label "lung plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in lung to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00286 a rdfs:Class ;
rdfs:label "estimated daily intake" ;
rdfs:comment "An output parameter estimating the amount of a compound consumed daily (EDI)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00316 a rdfs:Class ;
rdfs:label "population pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model approach used to characterize interindividual variability within a population." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00033 a rdfs:Class ;
rdfs:label "fraction of blood flow to fat" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the fat compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00141 a rdfs:Class ;
rdfs:label "absorption rate constant gut" ;
rdfs:comment "An absorption rate constant parameter representing the rate constant for the movement of a compound from the gut to systemic circulation or another compartment." ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:PBPKO_00152 a rdfs:Class ;
rdfs:label "fraction unbound intestine" ;
rdfs:comment "An unbound fraction parameter specifically for the intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00573 a rdfs:Class ;
rdfs:label "heart blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the heart to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_06047 a rdfs:Class ;
rdfs:label "concentration in lumen" ;
rdfs:comment "The concentration of chemical in lumen of intestine." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00554 a rdfs:Class ;
rdfs:label "excreta compartment" ;
rdfs:comment "A compartment representing material eliminated from the body (e.g., urine, feces)." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_04110 a rdfs:Class ;
rdfs:label "volume of liver intracellular space" ;
rdfs:comment "A volume parameter representing the total volume of the hepatocytes in liver compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06065 a rdfs:Class ;
rdfs:label "amount in kidney proximal tubule tissue" ;
rdfs:comment "The amount of compound in the proximal tubule tissue of kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_03016 a rdfs:Class ;
rdfs:label "Hill dissociation constant" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:CHEBI_33839 a rdfs:Class ;
rdfs:label "macromolecule" ;
rdfs:comment "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ;
rdfs:subClassOf obo:COB_0000013 .
obo:PBPKO_00119 a rdfs:Class ;
rdfs:label "volume of lymph" ;
rdfs:comment "A volume parameter representing the total volume of lymph compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00146 a rdfs:Class ;
rdfs:label "distribution process" ;
rdfs:comment "A biological process describing the movement of a compound from systemic circulation to various organs/tissues." ;
rdfs:subClassOf obo:GO_0008150 .
obo:PBPKO_03044 a rdfs:Class ;
rdfs:label "medium albumin partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00503 a rdfs:Class ;
rdfs:label "amount in brain" ;
rdfs:comment "The amount of compound in the brain compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:NCBITaxon_2759 a rdfs:Class ;
rdfs:label "Eukaryota" ;
rdfs:subClassOf obo:COB_0000022 .
obo:PBPKO_03004 a rdfs:Class ;
rdfs:label "stomach uptake rate" ;
rdfs:comment "The absorption rate constant parameter representing the absorption rate from stomach to gut tissue or any intestine segment" ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:PBPKO_00246 a rdfs:Class ;
rdfs:label "intraarterial exposure" ;
rdfs:comment "A route of exposure involving administration directly into an artery." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_04083 a rdfs:Class ;
rdfs:label "fraction of adrenals" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_03027 a rdfs:Class ;
rdfs:label "metabolism rate constant in liver" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06014 a rdfs:Class ;
rdfs:label "amount in duodenum" ;
rdfs:comment "The amount of chemical in duodenum compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_06057 a rdfs:Class ;
rdfs:label "concentration in lysosomes" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00569 a rdfs:Class ;
rdfs:label "brain blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in brain to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00620 a rdfs:Class ;
rdfs:label "frontal cortex compartment" ;
rdfs:comment "A part of brain compartment representing the frontal cortex region of the brain" ;
rdfs:subClassOf obo:PBPKO_00466 .
obo:GO_0032991 a rdfs:Class ;
rdfs:label "protein-containing complex" ;
rdfs:comment "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
rdfs:subClassOf obo:COB_0000080 , obo:GO_0005575 .
obo:PBPKO_00007 a rdfs:Class ;
rdfs:label "body mass index" ;
rdfs:comment "A physiological parameter calculated as an individual's weight (kg) divided by the square of their height (m)." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_03050 a rdfs:Class ;
rdfs:label "cell radius" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04079 a rdfs:Class ;
rdfs:label "volume of cortical bone" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:CHEBI_24636 a rdfs:Class ;
rdfs:label "proton" ;
rdfs:comment "Nuclear particle of charge number +1, spin ½ and rest mass of 1.007276470(12) u." ;
rdfs:subClassOf obo:CHEBI_36342 , obo:COB_0000013 .
obo:PBPKO_00631 a rdfs:Class ;
rdfs:label "amount in arterial blood" ;
rdfs:comment "The amount of compound in the arterial blood compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_03013 a rdfs:Class ;
rdfs:label "effective Caco-2 permeability" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00048 a rdfs:Class ;
rdfs:label "blood flow rate to richly perfused" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the richly perfused organ/tissue compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00488 a rdfs:Class ;
rdfs:label "plasma compartment" ;
rdfs:comment "A compartment representing blood plasma." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_03056 a rdfs:Class ;
rdfs:label "cell fraction of lysosomes" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00520 a rdfs:Class ;
rdfs:label "urinary rate constant" ;
rdfs:comment "A biochemical parameter (rate constant) representing the rate at which a compound is cleared via urine, often scaled by body weight." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:CHEBI_36342 a rdfs:Class ;
rdfs:label "subatomic particle" ;
rdfs:comment "A particle smaller than an atom." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_06061 a rdfs:Class ;
rdfs:label "concentration in air" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00015 a rdfs:Class ;
rdfs:label "fraction of blood flow to stomach" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the stomach compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00514 a rdfs:Class ;
rdfs:label "fraction of blood flow to mammary gland" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00529 a rdfs:Class ;
rdfs:label "blood flow rate to filtrate" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the filtrate compartment (representing glomerular filtration)." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_06040 a rdfs:Class ;
rdfs:label "total venous rest body concentration" ;
rdfs:comment "The total venous concentration of compound in the rest of the body compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_04002 a rdfs:Class ;
rdfs:label "plasma flow rate to stomach" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the stomach compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:OBI_0000245 a rdfs:Class ;
rdfs:label "organization"@en ;
rdfs:comment "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00097 a rdfs:Class ;
rdfs:label "volume of lung" ;
rdfs:comment "A volume parameter representing the total volume of the lung compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00409 a rdfs:Class ;
rdfs:label "fraction of blood flow to duodenum" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the duodenum compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00461 a rdfs:Class ;
rdfs:label "anal canal compartment" ;
rdfs:comment "A large intestine compartment representing the anal canal." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_00442 a rdfs:Class ;
rdfs:label "milk plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in milk to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04057 a rdfs:Class ;
rdfs:label "volume fraction of blood" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00431 a rdfs:Class ;
rdfs:label "diffusion coefficient" ;
rdfs:comment "A physicochemical parameter representing the amount of substance diffusing across a unit area per unit time under a unit concentration gradient." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:IAO_0000003 a rdfs:Class ;
rdfs:label "measurement unit label"@en ;
rdfs:comment "A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure."@en ;
rdfs:subClassOf obo:IAO_0000009 .
obo:PBPKO_00135 a rdfs:Class ;
rdfs:label "physiological charge" ;
rdfs:comment "A physicochemical parameter representing the electrical charge of a molecule at physiological pH." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00420 a rdfs:Class ;
rdfs:label "fraction of jejunum" ;
rdfs:comment "A dimensionless fraction of volume defined as the jejunum volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00182 a rdfs:Class ;
rdfs:label "skin stratum corneum partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the stratum corneum to the rest of the skin." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04024 a rdfs:Class ;
rdfs:label "plasma flow rate to duodenum" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the duodenum compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:OBI_0200050 a rdfs:Class ;
rdfs:label "dimensionality reduction"@en ;
rdfs:comment "A dimensionality reduction is data partitioning which transforms each input m-dimensional vector (x_1, x_2, ..., x_m) into an output n-dimensional vector (y_1, y_2, ..., y_n), where n is smaller than m."@en ;
rdfs:subClassOf obo:OBI_0200175 .
obo:PBPKO_04035 a rdfs:Class ;
rdfs:label "plasma flow rate to exposed skin" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the exposed skin compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00211 a rdfs:Class ;
rdfs:label "maximum rate in intestine" ;
rdfs:comment "A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in the intestine when the enzyme is saturated with substrate." ;
rdfs:subClassOf obo:PBPKO_00613 .
obo:PBPKO_00490 a rdfs:Class ;
rdfs:label "reproductive compartment" ;
rdfs:comment "A compartment representing reproductive organs (gonads)." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00423 a rdfs:Class ;
rdfs:label "fraction of cecum" ;
rdfs:comment "A dimensionless fraction of volume defined as the cecum volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_04099 a rdfs:Class ;
rdfs:label "fraction of the skin surface depot" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_06003 a rdfs:Class ;
rdfs:label "unbound concentration of compund in compartment" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00029 a rdfs:Class ;
rdfs:label "fraction of blood flow to muscle" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the muscle compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00026 a rdfs:Class ;
rdfs:label "blood flow rate to kidney" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00079 a rdfs:Class ;
rdfs:label "volume of kidney" ;
rdfs:comment "A volume parameter representing the total volume of the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04088 a rdfs:Class ;
rdfs:label "fraction of large intestinal lumen" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00018 a rdfs:Class ;
rdfs:label "blood flow rate to small intestine" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the small intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00290 a rdfs:Class ;
rdfs:label "acceptable daily intake" ;
rdfs:comment "An output parameter (or exposure limit) estimating the amount of a substance in food/water that can be consumed daily without appreciable health risk (ADI)." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_01507 a rdfs:Class ;
rdfs:label "oat1" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_00612 a rdfs:Class ;
rdfs:label "apparent permeability" ;
rdfs:comment "A biochemical parameter representing the apparent permeability of a compound specifically between the compartments." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00351 a rdfs:Class ;
rdfs:label "blood brain barrier compartment" ;
rdfs:comment "A barrier compartment representing the blood-brain barrier (BBB)." ;
rdfs:subClassOf obo:PBPKO_00495 .
obo:PBPKO_00086 a rdfs:Class ;
rdfs:label "fraction of fat" ;
rdfs:comment "A dimensionless fraction of volume defined as the fat volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00623 a rdfs:Class ;
rdfs:label "amount in blood" ;
rdfs:comment "The amount of compound in the blood compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_04061 a rdfs:Class ;
rdfs:label "volume of exposed viable epidermis" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00037 a rdfs:Class ;
rdfs:label "fraction of blood flow to skin" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00584 a rdfs:Class ;
rdfs:label "poor perfused blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the poorly perfused compartment to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00477 a rdfs:Class ;
rdfs:label "gut compartment" ;
rdfs:comment "A digestive system compartment representing the gut (general term, often synonymous with intestine or GI tract)." ;
rdfs:subClassOf obo:PBPKO_00553 .
obo:PBPKO_00642 a rdfs:Class ;
rdfs:label "dermal absorption rate exposed skin" ;
rdfs:comment "An absorption rate constant parameter representing dermal absorption rate flux through exposed skin" ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:PBPKO_00412 a rdfs:Class ;
rdfs:label "fraction of blood flow to colon" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the colon compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_04029 a rdfs:Class ;
rdfs:label "plasma flow rate to filtrate" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the filtrate compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_04010 a rdfs:Class ;
rdfs:label "plasma flow rate to heart" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the heart compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00256 a rdfs:Class ;
rdfs:label "area under curve" ;
rdfs:comment "An output parameter representing the integral of the concentration-time curve (AUC), indicating total exposure." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00138 a rdfs:Class ;
rdfs:label "rotatable bond count" ;
rdfs:comment "A physicochemical parameter representing the integer count of rotatable bonds in a molecular entity." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_00535 a rdfs:Class ;
rdfs:label "resorption maximum" ;
rdfs:comment "A biochemical parameter (Tm) representing the maximum rate of tubular resorption (e.g., in the kidney)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00064 a rdfs:Class ;
rdfs:label "venous blood flow rate" ;
rdfs:comment "A blood flow rate parameter representing the rate of blood flow returning through the venous compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00226 a rdfs:Class ;
rdfs:label "exhalation" ;
rdfs:comment "An excretion process involving the elimination of volatile compounds and metabolites through respiration." ;
rdfs:subClassOf obo:GO_0007588 .
obo:PBPKO_00304 a rdfs:Class ;
rdfs:label "maximum rate of basolateral transporter in vitro" ;
rdfs:comment "Maximum rate (Vmax) of transport via a basolateral transporter, measured in vitro." ;
rdfs:subClassOf obo:PBPKO_00613 .
obo:PBPKO_03024 a rdfs:Class ;
rdfs:label "reabsorption rate constant" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04101 a rdfs:Class ;
rdfs:label "fraction of bone marrow" ;
rdfs:comment "A dimensionless fraction of volume defined as the bone marrow volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00453 a rdfs:Class ;
rdfs:label "richly perfused tissue compartment" ;
rdfs:comment "A compartment representing lumped tissues with high blood flow relative to their volume." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00106 a rdfs:Class ;
rdfs:label "fraction of rest body" ;
rdfs:comment "A dimensionless fraction of volume defined as the rest of body volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_06038 a rdfs:Class ;
rdfs:label "total venous skin concentration" ;
rdfs:comment "The total venous concentration of compound in the skin compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00281 a rdfs:Class ;
rdfs:label "median organ concentration" ;
rdfs:comment "An output parameter representing the median concentration of a compound in a specific organ after exposure." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00360 a rdfs:Class ;
rdfs:label "blood flow rate to frontal cortex" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the frontal cortex compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:IAO_0000038 a rdfs:Class ;
rdfs:label "graph"@en ;
rdfs:comment "A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way."@en ;
rdfs:subClassOf obo:IAO_0000308 .
obo:PBPKO_00296 a rdfs:Class ;
rdfs:label "reference human data set" ;
rdfs:comment "A data set containing the physiological parameters representing a standard human, often defined by specific characteristics like 70 kg body weight." ;
rdfs:subClassOf obo:IAO_0000100 .
obo:PBPKO_00170 a rdfs:Class ;
rdfs:label "liver plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in liver to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00084 a rdfs:Class ;
rdfs:label "fraction of heart" ;
rdfs:comment "A dimensionless fraction of volume defined as the heart volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:OBI_0200041 a rdfs:Class ;
rdfs:label "k-means clustering"@en ;
rdfs:comment "A k-means clustering is a data transformation which achieves a class discovery or partitioning objective, which takes as input a collection of objects (represented as points in multidimensional space) and which partitions them into a specified number k of clusters. The algorithm attempts to find the centers of natural clusters in the data. The most common form of the algorithm starts by partitioning the input points into k initial sets, either at random or using some heuristic data. It then calculates the mean point, or centroid, of each set. It constructs a new partition by associating each point with the closest centroid. Then the centroids are recalculated for the new clusters, and the algorithm repeated by alternate applications of these two steps until convergence, which is obtained when the points no longer switch clusters (or alternatively centroids are no longer changed)."@en ;
rdfs:subClassOf obo:OBI_0200171 , obo:OBI_0200175 .
obo:IAO_0000102 a rdfs:Class ;
rdfs:label "data about an ontology part"@en ;
rdfs:comment "Data about an ontology part is a data item about a part of an ontology, for example a term"@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:OBI_0000648 a rdfs:Class ;
rdfs:label "clustered data set"@en ;
rdfs:comment "A data set that is produced as the output of a class discovery data transformation and consists of a data set with assigned discovered class labels."@en ;
rdfs:subClassOf obo:IAO_0000100 .
obo:PBPKO_00383 a rdfs:Class ;
rdfs:label "blood flow rate to liverfetus" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the fetal liver compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_03076 a rdfs:Class ;
rdfs:label "fraction unbound kidney proximal tubule" ;
rdfs:comment "An unbound fraction parameter specifically for the kidney proximal tubule." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_04077 a rdfs:Class ;
rdfs:label "volume of urinary tract" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00053 a rdfs:Class ;
rdfs:label "fraction of blood flow to gall bladder" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the gall bladder compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_06050 a rdfs:Class ;
rdfs:label "concentration in feces" ;
rdfs:comment "The concentration of chemical in feces." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:OBI_0200190 a rdfs:Class ;
rdfs:label "clustered data visualization" ;
rdfs:comment "A data visualization which has input of a clustered data set and produces an output of a report graph which is capable of rendering data of this type."@en ;
rdfs:subClassOf obo:OBI_0200111 .
obo:PBPKO_00464 a rdfs:Class ;
rdfs:label "blood compartment" ;
rdfs:comment "A compartment representing the entirety of the blood (including plasma and cells)." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_04072 a rdfs:Class ;
rdfs:label "volume of gut intestinal tract" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00011 a rdfs:Class ;
rdfs:label "assigned race" ;
rdfs:comment "A parameter representing a geographic ancestral origin category assigned to a population group." ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:PBPKO_00076 a rdfs:Class ;
rdfs:label "fraction of pancreas" ;
rdfs:comment "A dimensionless fraction of volume defined as the pancreas volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_03046 a rdfs:Class ;
rdfs:label "acidic phospholipid association constant" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00270 a rdfs:Class ;
rdfs:label "absorption phase" ;
rdfs:comment "An absorption process phase describing the period where the compound moves from the administration site into systemic circulation." ;
rdfs:subClassOf obo:PBPKO_00140 .
obo:PBPKO_00333 a rdfs:Class ;
rdfs:label "fetus lifestage" ;
rdfs:comment "A lifestage parameter representing the unborn offspring from the postembryonic stage until birth." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_00112 a rdfs:Class ;
rdfs:label "volume of stratum corneum exposed" ;
rdfs:comment "A volume parameter representing the total volume of the exposed stratum corneum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00087 a rdfs:Class ;
rdfs:label "volume of gonad" ;
rdfs:comment "A volume parameter representing the total volume of the gonad compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00111 a rdfs:Class ;
rdfs:label "volume of unexposed skin" ;
rdfs:comment "A volume parameter representing the total volume of the unexposed skin compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00546 a rdfs:Class ;
rdfs:label "concentration in skin" ;
rdfs:comment "The total concentration of compound in the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00149 a rdfs:Class ;
rdfs:label "unbound fraction" ;
rdfs:comment "A biochemical parameter representing the fraction of a compound that is not bound (e.g., to proteins)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04049 a rdfs:Class ;
rdfs:label "diameter of the large intestine lumen" ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00506 a rdfs:Class ;
rdfs:label "amount in skin" ;
rdfs:comment "The amount of compound in the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00022 a rdfs:Class ;
rdfs:label "blood flow rate to pancreas" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the pancreas compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00159 a rdfs:Class ;
rdfs:label "fraction unbound gonad" ;
rdfs:comment "An unbound fraction parameter specifically for the gonad compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_04022 a rdfs:Class ;
rdfs:label "plasma flow rate to portal vein" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the portal vein compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00181 a rdfs:Class ;
rdfs:label "poor perfused plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the lumped poorly perfused compartment to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_04044 a rdfs:Class ;
rdfs:label "hepatic vein blood flow" ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00073 a rdfs:Class ;
rdfs:label "volume of large intestine" ;
rdfs:comment "A volume parameter representing the total volume of the large intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06027 a rdfs:Class ;
rdfs:label "unbound venous mammary gland concentration" ;
rdfs:comment "The unbound venous concentration of compound in the mammary gland compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
obo:PBPKO_03011 a rdfs:Class ;
rdfs:label "kinetic absorption rate from ileum lumen to intestinal tissue" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00379 a rdfs:Class ;
rdfs:label "volume of rest body fetus" ;
rdfs:comment "A volume parameter representing the total volume of the rest of body compartment within the fetus." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PATO_0000001 a rdfs:Class ;
rdfs:label "quality" ;
rdfs:subClassOf obo:BFO_0000020 .
obo:PBPKO_06005 a rdfs:Class ;
rdfs:label "amount in small intestine" ;
rdfs:comment "The amount of chemical in small intestine compartment" ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00200 a rdfs:Class ;
rdfs:label "phase II" ;
rdfs:comment "A metabolism process involving the conjugation of phase I products (or parent compounds) to hydrophilic moieties to facilitate excretion." ;
rdfs:subClassOf obo:GO_0008152 .
obo:IAO_0000010 a rdfs:Class ;
rdfs:label "software"@en ;
rdfs:comment """Software is a plan specification composed of a series of instructions that can be
interpreted by or directly executed by a processing unit."""@en ;
rdfs:subClassOf obo:IAO_0000104 .
obo:PBPKO_00372 a rdfs:Class ;
rdfs:label "fetoplacental volume" ;
rdfs:comment "A volume parameter representing the total volume of the placental compartment for fetus." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_06016 a rdfs:Class ;
rdfs:label "amount in portal vein" ;
rdfs:comment "The amount of chemical in portal vein." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00215 a rdfs:Class ;
rdfs:label "gut metabolism" ;
rdfs:comment "A metabolism process specifically occurring within the gut." ;
rdfs:subClassOf obo:GO_0008152 .
obo:PBPKO_00095 a rdfs:Class ;
rdfs:label "volume of spleen" ;
rdfs:comment "A volume parameter representing the total volume of the spleen compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04055 a rdfs:Class ;
rdfs:label "fraction of bile in liver" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00539 a rdfs:Class ;
rdfs:label "concentration in liver" ;
rdfs:comment "The total concentration of compound in the liver compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:OBI_0002215 a rdfs:Class ;
rdfs:label "histologic grade for ovarian tumor" ;
rdfs:comment "A categorical value specification that is a histologic grade assigned to a ovarian tumor."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:PBPKO_02008 a rdfs:Class ;
rdfs:label "kidney rest lumen compartment" ;
rdfs:comment "A compartment representing rest of the lumen of kidney." ;
rdfs:subClassOf obo:PBPKO_00557 .
obo:PBPKO_00358 a rdfs:Class ;
rdfs:label "volume of cerebellum" ;
rdfs:comment "A volume parameter representing the total volume of the cerebellum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00140 a rdfs:Class ;
rdfs:label "absorption" ;
rdfs:comment "A biological process by which a compound moves from its site of administration into the systemic circulation or a target tissue." ;
rdfs:subClassOf obo:GO_0008150 .
obo:PBPKO_04066 a rdfs:Class ;
rdfs:label "volume of breast" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00551 a rdfs:Class ;
rdfs:label "PBPK model simulation time" ;
rdfs:comment "A parameter representing the time duration over which the model simulation runs." ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:PBPKO_00639 a rdfs:Class ;
rdfs:label "amount in skin stratum corneum of unexposed skin" ;
rdfs:comment "The amount of chemical in skin stratum corneum of unexposed skin" ;
rdfs:subClassOf obo:PBPKO_00506 .
obo:PBPKO_06011 a rdfs:Class ;
rdfs:label "amount in colon" ;
rdfs:comment "The amount of chemical in colon compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00229 a rdfs:Class ;
rdfs:label "clearance rate" ;
rdfs:comment "A biochemical parameter representing the volume of biological fluid cleared of a compound per unit time." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00267 a rdfs:Class ;
rdfs:label "bioequivalence" ;
rdfs:comment "An output parameter indicating comparable bioavailability between test and reference formulations under similar conditions." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00008 a rdfs:Class ;
rdfs:label "bodyweight" ;
rdfs:comment "A physiological parameter representing the mass or quantity of heaviness of an individual." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_04106 a rdfs:Class ;
rdfs:label "volume of kidney rest lumen" ;
rdfs:comment "A volume parameter representing the total volume of the kidney rest lumen compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_04097 a rdfs:Class ;
rdfs:label "fraction of cortical bone" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00457 a rdfs:Class ;
rdfs:label "skin unexposed stratum corneum" ;
rdfs:comment "A stratum corneum compartment representing the portion not directly exposed to the applied compound." ;
rdfs:subClassOf obo:PBPKO_00493 .
obo:PBPKO_00047 a rdfs:Class ;
rdfs:label "fraction of blood flow to poorly perfused" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the poorly perfused compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_03071 a rdfs:Class ;
rdfs:label "ionized fraction in the medium" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00628 a rdfs:Class ;
rdfs:label "fraction of venous plasma volume" ;
rdfs:comment "A dimensionless fraction of volume defined as the venous plasma volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00349 a rdfs:Class ;
rdfs:label "cranial cerebrospinal fluid volume" ;
rdfs:comment "A volume parameter representing the total volume of cerebrospinal fluid (CSF) compartment in the cranial region." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_03007 a rdfs:Class ;
rdfs:label "intrinsic biliary clearance rate" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00562 a rdfs:Class ;
rdfs:label "blood flow rate to unexposed skin" ;
rdfs:comment "A blood flow rate to skin parameter specifically describing the rate to the unexposed portion of the skin compartment." ;
rdfs:subClassOf obo:PBPKO_00036 .
obo:PBPKO_03060 a rdfs:Class ;
rdfs:label "culture area" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06049 a rdfs:Class ;
rdfs:label "concentration in spleen" ;
rdfs:comment "The concentration of chemical in spleen compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00495 a rdfs:Class ;
rdfs:label "barrier compartment" ;
rdfs:comment "A compartment representing a physiological barrier limiting compound movement." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:OBI_0000112 a rdfs:Class ;
rdfs:label "specimen role"@en ;
rdfs:comment "A role borne by a material entity that is obtained during a specimen collection process and that can be realized by performing measurements or observations on the specimen."@en ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PBPKO_06054 a rdfs:Class ;
rdfs:label "concentration in medium" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00092 a rdfs:Class ;
rdfs:label "fraction of bone" ;
rdfs:comment "A dimensionless fraction of volume defined as the bone volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00312 a rdfs:Class ;
rdfs:label "plasma space" ;
rdfs:comment "A physiological parameter representing the volume occupied by plasma within a tissue or the body." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:PBPKO_00568 a rdfs:Class ;
rdfs:label "air blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in air to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_03033 a rdfs:Class ;
rdfs:label "partition coeffcient of viable epidermis to blood" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00069 a rdfs:Class ;
rdfs:label "volume of intestine" ;
rdfs:comment "A volume parameter representing the total volume of the intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00528 a rdfs:Class ;
rdfs:label "cardiac output rate of plasma" ;
rdfs:comment "A blood flow rate parameter representing the cardiac output specifically related to plasma flow." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00393 a rdfs:Class ;
rdfs:label "kidneyfetus plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal kidney to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:OBI_0200175 a rdfs:Class ;
rdfs:label "class discovery data transformation"@en ;
rdfs:comment "A class discovery data transformation (sometimes called unsupervised classification) is a data transformation that has objective class discovery."@en ;
rdfs:subClassOf obo:OBI_0200000 .
obo:PBPKO_00058 a rdfs:Class ;
rdfs:label "amount of metabolized" ;
rdfs:comment "An output parameter representing the total amount of compound metabolized." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_03035 a rdfs:Class ;
rdfs:label "partition coeffcient of follicle to skin surface depot" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00187 a rdfs:Class ;
rdfs:label "blood:plasma ratio" ;
rdfs:comment "A biochemical parameter representing the ratio of compound concentration in whole blood to that in plasma." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00219 a rdfs:Class ;
rdfs:label "abcc3" ;
rdfs:comment "A transporter (ATP-binding cassette subfamily C member 3) involved in bile metabolism and transport." ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_00323 a rdfs:Class ;
rdfs:label "linear elimination" ;
rdfs:comment "An elimination process that follows first-order kinetics (rate proportional to concentration)." ;
rdfs:subClassOf obo:PBPKO_00322 .
obo:PBPKO_00517 a rdfs:Class ;
rdfs:label "mammary gland plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the mammary gland to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00587 a rdfs:Class ;
rdfs:label "rich perfused blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the richly perfused compartment to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00419 a rdfs:Class ;
rdfs:label "fraction of duodenum" ;
rdfs:comment "A dimensionless fraction of volume defined as the duodenum volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_03054 a rdfs:Class ;
rdfs:label "cell fraction of intracellular water" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00162 a rdfs:Class ;
rdfs:label "fraction unbound spleen" ;
rdfs:comment "An unbound fraction parameter specifically for the spleen compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PR_000018263 a rdfs:Class ;
rdfs:label "amino acid chain" ;
rdfs:comment "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." ;
rdfs:subClassOf obo:COB_0000013 .
obo:PBPKO_00307 a rdfs:Class ;
rdfs:label "Michaelis constant apical" ;
rdfs:comment "Michaelis constant representing the substrate concentration at half-maximal velocity (Km) for an apical transporter." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00468 a rdfs:Class ;
rdfs:label "descending colon compartment" ;
rdfs:comment "A large intestine compartment representing the descending colon." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_00617 a rdfs:Class ;
rdfs:label "hippocampus compartment" ;
rdfs:comment "A part of brain compartment representing the hippocampus region of the brain" ;
rdfs:subClassOf obo:PBPKO_00466 .
obo:PBPKO_06059 a rdfs:Class ;
rdfs:label "concentration in intracellular water" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_04050 a rdfs:Class ;
rdfs:label "surface area of the jejunum lumen" ;
rdfs:subClassOf obo:PBPKO_00010 .
obo:BFO_0000003 a rdfs:Class ;
rdfs:label "occurrent"@en ;
rdfs:comment "An entity that has temporal parts and that happens, unfolds or develops through time."@en .
obo:PBPKO_02012 a rdfs:Class ;
rdfs:label "gastro intestinal tract compartment" ;
rdfs:comment "A digestive system compartment representing the gastro-intestinal tract" ;
rdfs:subClassOf obo:PBPKO_00553 .
obo:PBPKO_00576 a rdfs:Class ;
rdfs:label "kidneyfetus blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal kidney to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00557 a rdfs:Class ;
rdfs:label "kidney compartment" ;
rdfs:comment "A compartment representing the kidney(s)." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00369 a rdfs:Class ;
rdfs:label "apparent permeability hippocampus to rest of brain" ;
rdfs:comment "Apparent permeability of a compound specifically between the hippocampus and the rest of the brain." ;
rdfs:subClassOf obo:PBPKO_00612 .
obo:PBPKO_04011 a rdfs:Class ;
rdfs:label "plasma flow rate to fat" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the fat compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00338 a rdfs:Class ;
rdfs:label "adolescent lifestage" ;
rdfs:comment "A lifestage parameter representing the transitional stage between teenager and adulthood (approx. 15-18 years)." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:NCBITaxon_33213 a rdfs:Class ;
rdfs:label "Bilateria" ;
rdfs:subClassOf obo:NCBITaxon_33208 .
obo:PBPKO_03065 a rdfs:Class ;
rdfs:label "fraction of serum in total media" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00176 a rdfs:Class ;
rdfs:label "skin plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in skin to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:OBI_0200178 a rdfs:Class ;
rdfs:label "class discovery objective"@en ;
rdfs:comment "A class discovery objective (sometimes called unsupervised classification) is a data transformation objective where the aim is to organize input data (typically vectors of attributes) into classes, where the number of classes and their specifications are not known a priori. Depending on usage, the class assignment can be definite or probabilistic."@en ;
rdfs:subClassOf obo:OBI_0200166 .
obo:PBPKO_04087 a rdfs:Class ;
rdfs:label "fraction of small intestinal lumen" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00416 a rdfs:Class ;
rdfs:label "blood flow rate to ileum" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the ileum compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_03057 a rdfs:Class ;
rdfs:label "cell fraction of microsomes" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_04062 a rdfs:Class ;
rdfs:label "volume of follicle" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00319 a rdfs:Class ;
rdfs:label "one-compartment pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model that treats the entire body as a single, kinetically homogenous unit (central compartment)." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00641 a rdfs:Class ;
rdfs:label "dermal absorption rate unexposed skin" ;
rdfs:comment "An absorption rate constant parameter representing dermal absorption rate flux through unexposed skin" ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:COB_0000013 a rdfs:Class ;
rdfs:label "molecule"@en ;
rdfs:comment "A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00572 a rdfs:Class ;
rdfs:label "gut blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the gut to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_06044 a rdfs:Class ;
rdfs:label "concentration in ileum" ;
rdfs:comment "The concentration of chemical in ileum compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_04016 a rdfs:Class ;
rdfs:label "plasma flow rate to spleen" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the spleen compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_03017 a rdfs:Class ;
rdfs:label "Hill coefficient" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_06030 a rdfs:Class ;
rdfs:label "total venous liver concentration" ;
rdfs:comment "The total venous concentration of compound in the liver compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00484 a rdfs:Class ;
rdfs:label "muscle compartment" ;
rdfs:comment "A compartment representing muscle tissue." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_06058 a rdfs:Class ;
rdfs:label "concentration in microsomes" ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00524 a rdfs:Class ;
rdfs:label "volume of gut" ;
rdfs:comment "A volume parameter representing the total volume of the gut compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_01506 a rdfs:Class ;
rdfs:label "oct1" ;
rdfs:subClassOf obo:PBPKO_00217 .
obo:PBPKO_04080 a rdfs:Class ;
rdfs:label "volume of trabecular bone" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00456 a rdfs:Class ;
rdfs:label "viable exposed skin compartment" ;
rdfs:comment "A skin compartment representing the viable layers of skin directly exposed to the applied compound." ;
rdfs:subClassOf obo:PBPKO_00470 .
obo:PBPKO_03043 a rdfs:Class ;
rdfs:label "medium other organelles partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00510 a rdfs:Class ;
rdfs:label "fraction of mammary gland" ;
rdfs:comment "A dimensionless fraction of volume defined as the mammary gland volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00394 a rdfs:Class ;
rdfs:label "restbodyfetus plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the fetal rest of body compartment to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00019 a rdfs:Class ;
rdfs:label "fraction of blood flow to small intestine" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the small intestine compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00225 a rdfs:Class ;
rdfs:label "fecal excretion" ;
rdfs:comment "An excretion process involving the elimination of compounds and metabolites through feces." ;
rdfs:subClassOf obo:GO_0007588 .
obo:PBPKO_00624 a rdfs:Class ;
rdfs:label "fraction unbound restbody" ;
rdfs:comment "An unbound fraction parameter specifically for the rest of the body compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_03003 a rdfs:Class ;
rdfs:label "intrinsic stomach uptake rate" ;
rdfs:comment "The absorption rate constant parameter representing the intrinsic absorption rate of a chemical from the stomach to the gut tissue or any intestinal segment" ;
rdfs:subClassOf obo:PBPKO_03075 .
obo:OBI_0100051 a rdfs:Class ;
rdfs:label "specimen"@en ;
rdfs:comment "A material entity that is collected for potential use as an input upon which measurements or observations are performed."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00043 a rdfs:Class ;
rdfs:label "fraction of blood flow to spleen" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the spleen compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_02007 a rdfs:Class ;
rdfs:label "menstrual plasma compartment" ;
rdfs:comment "A compartment representing menstrual plasma" ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_04109 a rdfs:Class ;
rdfs:label "volume of liver extracellular" ;
rdfs:comment "A volume parameter representing the total volume of the vascular and interstitial spaces of liver compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_03032 a rdfs:Class ;
rdfs:label "partition coeffcient of stratum corneum to viable epidermis" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00357 a rdfs:Class ;
rdfs:label "volume of cerebrum" ;
rdfs:comment "A volume parameter representing the total volume of the cerebrum compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00368 a rdfs:Class ;
rdfs:label "apparent permeability cerebellum to rest of brain" ;
rdfs:comment "Apparent permeability of a compound specifically between the cerebellum and the rest of the brain." ;
rdfs:subClassOf obo:PBPKO_00612 .
obo:PBPKO_02001 a rdfs:Class ;
rdfs:label "bile compartment" ;
rdfs:comment "A compartment representing the bile storage" ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_04093 a rdfs:Class ;
rdfs:label "fraction of skeleton" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00405 a rdfs:Class ;
rdfs:label "thoracic compartment" ;
rdfs:comment "A compartment representing the thoracic region (chest)." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_04006 a rdfs:Class ;
rdfs:label "plasma flow rate to pancreas" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the pancreas compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00613 a rdfs:Class ;
rdfs:label "maximum rate" ;
rdfs:comment "A biochemical parameter representing Vmax of the enzymatic activity" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00592 a rdfs:Class ;
rdfs:label "maximum rate of apical transporter" ;
rdfs:comment "A maximum rate (Vmax) of an enzyme catalysed reaction for a compound across the apical membrane of an organ when the enzyme is saturated with substrate." ;
rdfs:subClassOf obo:PBPKO_00613 .
obo:PBPKO_00473 a rdfs:Class ;
rdfs:label "endocrine gland compartment" ;
rdfs:comment "A compartment representing endocrine glands." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00467 a rdfs:Class ;
rdfs:label "cecum compartment" ;
rdfs:comment "A large intestine compartment representing the cecum." ;
rdfs:subClassOf obo:PBPKO_00474 .
obo:PBPKO_02013 a rdfs:Class ;
rdfs:label "gonad compartment" ;
rdfs:comment "A compartment representing gonads." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00427 a rdfs:Class ;
rdfs:label "volume of colon" ;
rdfs:comment "A volume parameter representing the total volume of the colon compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:PBPKO_00371 a rdfs:Class ;
rdfs:label "pregnant pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model specifically built to predict compound concentrations during pregnancy." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:PBPKO_00513 a rdfs:Class ;
rdfs:label "fraction of blood flow to gut" ;
rdfs:comment "The dimensionless fraction of cardiac output delivered to the gut compartment." ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_04038 a rdfs:Class ;
rdfs:label "fraction of blood flow to red blood cells" ;
rdfs:subClassOf obo:PBPKO_00611 .
obo:PBPKO_00214 a rdfs:Class ;
rdfs:label "Michaelis constant liver" ;
rdfs:comment "Michaelis constant representing the substrate concentration at which the reaction rate in the liver is half of Vmax (Km)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:OBI_0200179 a rdfs:Class ;
rdfs:label "class prediction objective"@en ;
rdfs:comment """A class prediction objective (sometimes called supervised classification) is a data transformation objective where the aim is to create a predictor from training data through a machine learning technique. The training data consist of pairs of objects (typically vectors of attributes) and
class labels for these objects. The resulting predictor can be used to attach class labels to any valid novel input object. Depending on usage, the prediction can be definite or probabilistic. A classification is learned from the training data and can then be tested on test data."""@en ;
rdfs:subClassOf obo:OBI_0200166 .
obo:PBPKO_00583 a rdfs:Class ;
rdfs:label "pancreas blood partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in the pancreas to blood." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00166 a rdfs:Class ;
rdfs:label "gut plasma partition coefficient" ;
rdfs:comment "A partition coefficient representing the ratio of compound concentration in gut to plasma." ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00591 a rdfs:Class ;
rdfs:label "fraction unbound plasma" ;
rdfs:comment "An unbound fraction parameter specifically for plasma." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_03039 a rdfs:Class ;
rdfs:label "medium mitochondria partition coefficient" ;
rdfs:subClassOf obo:PBPKO_00165 .
obo:PBPKO_00151 a rdfs:Class ;
rdfs:label "fraction unbound stomach" ;
rdfs:comment "An unbound fraction parameter specifically for the stomach compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:BFO_0000031 a rdfs:Class ;
rdfs:label "generically dependent continuant"@en ;
rdfs:subClassOf obo:BFO_0000002 .
obo:PBPKO_06022 a rdfs:Class ;
rdfs:label "unbound venous filtrate concentration" ;
rdfs:comment "The unbound venous concentration of compound in the filtrate compartment." ;
rdfs:subClassOf obo:PBPKO_06002 .
a rdfs:Class ;
rdfs:comment "An unconstrained type or object" .
obo:PBPKO_00350 a rdfs:Class ;
rdfs:label "brain mass" ;
rdfs:comment "A physiological parameter representing the mass of the brain." ;
rdfs:subClassOf obo:PBPKO_00006 .
obo:OBI_0000727 a rdfs:Class ;
rdfs:label "k-nearest neighbors"@en ;
rdfs:comment "A k-nearest neighbors is a data transformation which achieves a class discovery or partitioning objective, in which an input data object with vector y is assigned to a class label based upon the k closest training data set points to y; where k is the largest value that class label is assigned."@en ;
rdfs:subClassOf obo:OBI_0200171 , obo:OBI_0200175 .
obo:PBPKO_02003 a rdfs:Class ;
rdfs:label "small intestine tissue compartment" ;
rdfs:comment "A compartment representing the small intestinal tissue" ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_03028 a rdfs:Class ;
rdfs:label "metabolism rate constant in intestinal tissue" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:OBI_0000659 a rdfs:Class ;
rdfs:label "specimen collection process" ;
rdfs:comment "A planned process with the objective to obtain a material entity for potential use as an input upon which measurements or observations are performed."@en ;
rdfs:subClassOf obo:COB_0000035 .
obo:GO_0005575 a rdfs:Class ;
rdfs:label "cellular_component" ;
rdfs:comment "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:PBPKO_00341 a rdfs:Class ;
rdfs:label "old age lifestage" ;
rdfs:comment "A lifestage parameter representing individuals typically from forty-five to sixty years old (or older, definitions vary)." ;
rdfs:subClassOf obo:PBPKO_00332 .
obo:PBPKO_00134 a rdfs:Class ;
rdfs:label "basic dissociation constant" ;
rdfs:comment "A physicochemical parameter representing the negative base-10 logarithm (pKb) of the base dissociation constant (Kb)." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:PBPKO_06051 a rdfs:Class ;
rdfs:label "amount in skin surface depot" ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:PBPKO_00301 a rdfs:Class ;
rdfs:label "concentration in blood" ;
rdfs:comment "The total concentration of compound in the blood compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_04027 a rdfs:Class ;
rdfs:label "plasma flow rate to colon" ;
rdfs:comment "A plasma flow rate parameter specifically describing the rate to the colon compartment." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_04033 a rdfs:Class ;
rdfs:label "plasma flow rate for mass balance" ;
rdfs:comment "A plasma flow rate parameter representing the check for total plasma flow mass balance of all the compartments (sum of organ flows should equal cardiac output)." ;
rdfs:subClassOf obo:PBPKO_04001 .
obo:PBPKO_00630 a rdfs:Class ;
rdfs:label "amount in poorly perfused tissue" ;
rdfs:comment "The amount of compound in the poorly perfused tissue compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:IAO_0000005 a rdfs:Class ;
rdfs:label "objective specification"@en ;
rdfs:comment "A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved."@en ;
rdfs:subClassOf obo:IAO_0000033 .
obo:PBPKO_00279 a rdfs:Class ;
rdfs:label "min organ concentration" ;
rdfs:comment "An output parameter representing the minimum concentration of a compound in a specific organ after exposure." ;
rdfs:subClassOf obo:PBPKO_00252 .
obo:PBPKO_00408 a rdfs:Class ;
rdfs:label "gut pbpk" ;
rdfs:comment "A physiologically based pharmacokinetic model specifically built to predict compound concentrations within the gut compartments." ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:OBI_0200000 a rdfs:Class ;
rdfs:label "data transformation"@en ;
rdfs:comment "A completely executed planned process that produces output data from input data."@en ;
rdfs:subClassOf obo:COB_0000035 .
obo:PBPKO_00221 a rdfs:Class ;
rdfs:label "degradation rate constant" ;
rdfs:comment "A biochemical parameter (kdeg) representing the rate constant for the degradation of a metabolizing enzyme or transporter." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00315 a rdfs:Class ;
rdfs:label "effective permeability" ;
rdfs:comment "A biochemical parameter (Peff) representing the rate at which a compound passes through a biological barrier (e.g., intestinal wall)." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00032 a rdfs:Class ;
rdfs:label "blood flow rate to fat" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the fat (adipose tissue) compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_04082 a rdfs:Class ;
rdfs:label "fraction of serum" ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00239 a rdfs:Class ;
rdfs:label "route of exposure" ;
rdfs:comment "A parameter designating the body part or method through which exposure is introduced." ;
rdfs:subClassOf obo:PBPKO_00002 .
obo:PBPKO_06041 a rdfs:Class ;
rdfs:label "concentration in stomach" ;
rdfs:comment "The concentration of chemical in stomach compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_00127 a rdfs:Class ;
rdfs:label "molecular weight" ;
rdfs:comment "A physicochemical parameter representing the sum of the weights of all atoms in a molecule." ;
rdfs:subClassOf obo:PBPKO_00126 .
obo:IAO_0000179 a rdfs:Class ;
rdfs:label "histogram"@en ;
rdfs:comment """A histogram is a report graph which is a statistical description of a
distribution in terms of occurrence frequencies of different event classes."""@en ;
rdfs:subClassOf obo:IAO_0000038 .
obo:PBPKO_00210 a rdfs:Class ;
rdfs:label "first pass metabolism" ;
rdfs:comment "A metabolism process occurring at a specific location (e.g., liver, gut wall) after administration but before reaching systemic circulation, reducing the concentration of active compound." ;
rdfs:subClassOf obo:GO_0008152 .
obo:PBPKO_06033 a rdfs:Class ;
rdfs:label "total venous brain concentration" ;
rdfs:comment "The total venous concentration of compound in the brain compartment." ;
rdfs:subClassOf obo:PBPKO_06029 .
obo:PBPKO_00145 a rdfs:Class ;
rdfs:label "specific intestinal permeability" ;
rdfs:comment "A biochemical parameter representing the surface area-normalized transcellular permeability of the intestinal wall for a compound." ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00460 a rdfs:Class ;
rdfs:label "adipose compartment" ;
rdfs:comment "A compartment representing adipose (fat) tissue." ;
rdfs:subClassOf obo:PBPKO_00446 .
obo:PBPKO_00245 a rdfs:Class ;
rdfs:label "intramuscular exposure" ;
rdfs:comment "A route of exposure involving injection into a muscle." ;
rdfs:subClassOf obo:PBPKO_00239 .
obo:PBPKO_00382 a rdfs:Class ;
rdfs:label "fetal cardiac output rate" ;
rdfs:comment "A blood flow rate parameter representing the volume of blood pumped by the fetal heart compartment per unit time." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:PBPKO_00234 a rdfs:Class ;
rdfs:label "hepatic clearance rate" ;
rdfs:comment "A clearance rate specifically quantifying elimination via the liver (metabolism and/or biliary excretion)." ;
rdfs:subClassOf obo:PBPKO_00229 .
obo:PBPKO_04051 a rdfs:Class ;
rdfs:label "surface area of the ileum lumen" ;
rdfs:subClassOf obo:PBPKO_00010 .
obo:PBPKO_00116 a rdfs:Class ;
rdfs:label "fraction of gall bladder" ;
rdfs:comment "A dimensionless fraction of volume defined as the gall bladder volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:COB_0000035 a rdfs:Class ;
rdfs:label "completely executed planned process"@en ;
rdfs:subClassOf obo:COB_0000082 .
obo:PBPKO_00361 a rdfs:Class ;
rdfs:label "blood flow rate to cerebrum" ;
rdfs:comment "A blood flow rate parameter specifically describing the rate to the cerebrum compartment." ;
rdfs:subClassOf obo:PBPKO_00012 .
obo:NCBITaxon_40674 a rdfs:Class ;
rdfs:label "Mammalia" ;
rdfs:subClassOf obo:NCBITaxon_32524 .
obo:PBPKO_00102 a rdfs:Class ;
rdfs:label "fraction of richly perfused" ;
rdfs:comment "A dimensionless fraction of volume defined as the richly perfused compartment volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00098 a rdfs:Class ;
rdfs:label "fraction of lung" ;
rdfs:comment "A dimensionless fraction of volume defined as the lung volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_00502 a rdfs:Class ;
rdfs:label "amount in plasma" ;
rdfs:comment "The amount of compound in the plasma compartment." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:IAO_0000027 a rdfs:Class ;
rdfs:label "data entity"@en ;
rdfs:comment "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PBPKO_03021 a rdfs:Class ;
rdfs:label "enterohepatic recirculation rate constant" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_03068 a rdfs:Class ;
rdfs:label "nominal concentration of medium" ;
rdfs:subClassOf obo:PBPKO_00139 .
obo:PBPKO_00081 a rdfs:Class ;
rdfs:label "volume of muscle" ;
rdfs:comment "A volume parameter representing the total volume of muscle compartment." ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:OBI_0002076 a rdfs:Class ;
rdfs:label "collection of specimens"@en ;
rdfs:comment "A material entity that has two or more specimens as its parts."@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:RO_0002351 a rdf:Property ;
rdfs:label "has member"@en ;
rdfs:comment "has member is a mereological relation between a collection and an item." ;
rdfs:range obo:OBI_0100051 .
obo:PBPKO_00155 a rdfs:Class ;
rdfs:label "fraction unbound kidney" ;
rdfs:comment "An unbound fraction parameter specifically for the kidney compartment." ;
rdfs:subClassOf obo:PBPKO_00149 .
obo:PBPKO_00438 a rdfs:Class ;
rdfs:label "concentration in milk" ;
rdfs:comment "The total concentration of compound in the milk compartment." ;
rdfs:subClassOf obo:PBPKO_00616 .
obo:PBPKO_06009 a rdfs:Class ;
rdfs:label "amount in lumen" ;
rdfs:comment "The amount of chemical in lumen of the intestine." ;
rdfs:subClassOf obo:PBPKO_00615 .
obo:NCBITaxon_32524 a rdfs:Class ;
rdfs:label "Amniota" ;
rdfs:subClassOf obo:NCBITaxon_32523 .
obo:PBPKO_00070 a rdfs:Class ;
rdfs:label "fraction of intestine" ;
rdfs:comment "A dimensionless fraction of volume defined as the intestine volume divided per unit of total body weight." ;
rdfs:subClassOf obo:PBPKO_00610 .
obo:PBPKO_04040 a rdfs:Class ;
rdfs:label "volumen of lumen" ;
rdfs:subClassOf obo:PBPKO_00066 .
obo:IAO_0000310 a rdfs:Class ;
rdfs:label "document"@en ;
rdfs:comment "A collection of information content entities intended to be understood together as a whole"@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PBPKO_07001 a rdfs:Class ;
rdfs:label "invitro pbpk" ;
rdfs:subClassOf obo:PBPKO_00003 .
obo:IAO_0000111 a rdf:Property ;
rdfs:label "editor preferred term"@en ;
rdfs:comment "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
rdfs:range xsd:string .
obo:IAO_0000112 a rdf:Property ;
rdfs:label "example of usage"@en ;
rdfs:comment "A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold."@en ;
rdfs:range xsd:string .
obo:IAO_0000114 a rdf:Property ;
rdfs:label "has curation status"@en ;
rdfs:range xsd:string .
obo:IAO_0000115 a rdf:Property ;
rdfs:label "textual definition" ;
rdfs:comment "The official definition." ;
rdfs:range xsd:string .
obo:IAO_0000116 a rdf:Property ;
rdfs:label "editor note"@en ;
rdfs:comment "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
rdfs:range xsd:string .
obo:IAO_0000117 a rdf:Property ;
rdfs:label "term editor"@en ;
rdfs:comment "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
rdfs:range xsd:string .
obo:IAO_0000118 a rdf:Property ;
rdfs:label "alternative label"@en ;
rdfs:comment "A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like."@en ;
rdfs:range xsd:string .
obo:IAO_0000119 a rdf:Property ;
rdfs:label "definition source"@en ;
rdfs:comment "Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
rdfs:range xsd:string .
obo:IAO_0000232 a rdf:Property ;
rdfs:label "curator note"@en ;
rdfs:comment "An administrative note of use for a curator but of no use for a user"@en ;
rdfs:range xsd:string .
obo:IAO_0000233 a rdf:Property ;
rdfs:label "term tracker item"@en ;
rdfs:comment "A URL for a request or discussion of an ontology term."@en ;
rdfs:range xsd:string .
obo:IAO_0000412 a rdf:Property ;
rdfs:label "imported from"@en ;
rdfs:comment "For external terms/classes, the ontology from which the term was imported"@en ;
rdfs:range xsd:string .
obo:IAO_0000425 a rdf:Property ;
rdfs:label "expand assertion to"@en ;
rdfs:comment "A macro expansion tag applied to an annotation property which can be expanded into a more detailed axiom."@en ;
rdfs:range xsd:string .
obo:OBI_0000295 a rdf:Property ;
rdfs:label "is specified input of"@en ;
rdfs:comment "A relation between a completely executed planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of." ;
rdfs:range obo:COB_0000035 ;
rdfs:subPropertyOf obo:RO_0000056 .
obo:RO_0000052 a rdf:Property ;
rdfs:label "characteristic of"@en ;
rdfs:comment "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence."@en ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002314 .
obo:RO_0000053 a rdf:Property ;
rdfs:label "has characteristic"@en ;
rdfs:comment "Inverse of characteristic_of"@en ;
rdfs:range obo:BFO_0000020 .
obo:RO_0000080 a rdf:Property ;
rdfs:label "quality of"@en ;
rdfs:comment "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0000052 .
obo:RO_0000081 a rdf:Property ;
rdfs:label "role of"@en ;
rdfs:comment "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0000052 .
obo:RO_0000086 a rdf:Property ;
rdfs:label "has quality"@en ;
rdfs:comment "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ;
rdfs:range obo:BFO_0000019 ;
rdfs:subPropertyOf obo:RO_0000053 .
obo:RO_0000092 a rdf:Property ;
rdfs:label "disposition of"@en ;
rdfs:comment "inverse of has disposition" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0000052 .
obo:RO_0002013 a rdf:Property ;
rdfs:label "has regulatory component activity" ;
rdfs:comment "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002334 , obo:RO_0002017 .
obo:RO_0002014 a rdf:Property ;
rdfs:label "has negative regulatory component activity" ;
rdfs:comment "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002335 , obo:RO_0002013 .
obo:RO_0002015 a rdf:Property ;
rdfs:label "has positive regulatory component activity" ;
rdfs:comment "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002336 , obo:RO_0002013 .
obo:RO_0002017 a rdf:Property ;
rdfs:label "has component activity" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002018 .
obo:RO_0002022 a rdf:Property ;
rdfs:label "directly regulated by" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002334 .
obo:RO_0002023 a rdf:Property ;
rdfs:label "directly negatively regulated by" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002022 .
obo:RO_0002024 a rdf:Property ;
rdfs:label "directly positively regulated by" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002022 .
obo:RO_0002025 a rdf:Property ;
rdfs:label "has effector activity" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002017 .
obo:RO_0002086 a rdf:Property ;
rdfs:label "ends after"@en ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002222 .
obo:RO_0002087 a rdf:Property ;
rdfs:label "immediately preceded by"@en ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:BFO_0000062 .
obo:RO_0002090 a rdf:Property ;
rdfs:label "immediately precedes"@en ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:BFO_0000063 .
obo:RO_0002131 a rdf:Property ;
rdfs:label "overlaps"@en ;
rdfs:comment "x overlaps y if and only if there exists some z such that x has part z and z part of y" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002323 .
obo:RO_0002161 a rdf:Property ;
rdfs:label "never in taxon" ;
rdfs:comment "x never in taxon T if and only if T is a class, and x does not instantiate the class expression \"in taxon some T\". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL." ;
rdfs:range xsd:string .
obo:RO_0002171 a rdf:Property ;
rdfs:label "mutually spatially disjoint with"@en ;
rdfs:comment "A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B." ;
rdfs:range xsd:string .
obo:RO_0002175 a rdf:Property ;
rdfs:label "present in taxon"@en ;
rdfs:comment "S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S" ;
rdfs:range xsd:string .
obo:RO_0002180 a rdf:Property ;
rdfs:label "has component"@en ;
rdfs:comment "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:BFO_0000051 .
obo:RO_0002212 a rdf:Property ;
rdfs:label "negatively regulates"@en ;
rdfs:comment "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002305 , obo:RO_0002211 .
obo:RO_0002213 a rdf:Property ;
rdfs:label "positively regulates"@en ;
rdfs:comment "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002304 , obo:RO_0002211 .
obo:RO_0002216 a rdf:Property ;
rdfs:label "capable of part of"@en ;
rdfs:comment "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002500 , obo:RO_0002328 .
obo:RO_0002263 a rdf:Property ;
rdfs:label "acts upstream of" ;
rdfs:comment "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002264 .
obo:RO_0002264 a rdf:Property ;
rdfs:label "acts upstream of or within" ;
rdfs:comment "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002500 .
obo:RO_0002304 a rdf:Property ;
rdfs:label "causally upstream of, positive effect" ;
rdfs:comment "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0004047 , obo:RO_0002411 .
obo:RO_0002305 a rdf:Property ;
rdfs:label "causally upstream of, negative effect" ;
rdfs:comment "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0004046 , obo:RO_0002411 .
obo:RO_0002314 a rdf:Property ;
rdfs:label "characteristic of part of"@en ;
rdfs:comment "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002502 .
obo:RO_0002323 a rdf:Property ;
rdfs:label "mereotopologically related to"@en ;
rdfs:comment "A mereological relationship or a topological relationship" ;
rdfs:range .
obo:RO_0002327 a rdf:Property ;
rdfs:label "enables"@en ;
rdfs:comment "c enables p iff c is capable of p and c acts to execute p." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002215 .
obo:RO_0002328 a rdf:Property ;
rdfs:label "functionally related to"@en ;
rdfs:comment "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." ;
rdfs:range .
obo:RO_0002329 a rdf:Property ;
rdfs:label "part of structure that is capable of"@en ;
rdfs:comment "this relation holds between c and p when c is part of some c', and c' is capable of p." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002328 .
obo:RO_0002331 a rdf:Property ;
rdfs:label "involved in"@en ;
rdfs:comment "c involved_in p if and only if c enables some process p', and p' is part of p" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002431 , obo:RO_0000056 .
obo:RO_0002333 a rdf:Property ;
rdfs:label "enabled by"@en ;
rdfs:comment "inverse of enables" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000057 .
obo:RO_0002335 a rdf:Property ;
rdfs:label "negatively regulated by"@en ;
rdfs:comment "inverse of negatively regulates" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002334 .
obo:RO_0002336 a rdf:Property ;
rdfs:label "positively regulated by"@en ;
rdfs:comment "inverse of positively regulates" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002334 .
obo:RO_0002352 a rdf:Property ;
rdfs:label "input of"@en ;
rdfs:comment "inverse of has input" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0000056 .
obo:RO_0002404 a rdf:Property ;
rdfs:label "causally downstream of"@en ;
rdfs:comment "inverse of upstream of" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002427 , obo:BFO_0000062 .
obo:RO_0002405 a rdf:Property ;
rdfs:label "immediately causally downstream of"@en ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002404 , obo:RO_0002087 .
obo:RO_0002407 a rdf:Property ;
rdfs:label "indirectly positively regulates"@en ;
rdfs:comment "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0012012 , obo:RO_0002213 .
obo:RO_0002409 a rdf:Property ;
rdfs:label "indirectly negatively regulates"@en ;
rdfs:comment "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0012012 , obo:RO_0002212 .
obo:RO_0002410 a rdf:Property ;
rdfs:label "causally related to"@en ;
rdfs:range .
obo:RO_0002411 a rdf:Property ;
rdfs:label "causally upstream of"@en ;
rdfs:comment "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002418 , obo:BFO_0000063 .
obo:RO_0002412 a rdf:Property ;
rdfs:label "immediately causally upstream of"@en ;
rdfs:comment "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002411 , obo:RO_0002090 .
obo:RO_0002418 a rdf:Property ;
rdfs:label "causally upstream of or within" ;
rdfs:comment "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002501 .
obo:RO_0002427 a rdf:Property ;
rdfs:label "causally downstream of or within" ;
rdfs:comment "inverse of causally upstream of or within" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002501 .
obo:RO_0002428 a rdf:Property ;
rdfs:label "involved in regulation of" ;
rdfs:comment "c involved in regulation of p if c is involved in some p' and p' regulates some p" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002431 , obo:RO_0002263 .
obo:RO_0002429 a rdf:Property ;
rdfs:label "involved in positive regulation of" ;
rdfs:comment "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002428 .
obo:RO_0002430 a rdf:Property ;
rdfs:label "involved in negative regulation of" ;
rdfs:comment "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002428 .
obo:RO_0002431 a rdf:Property ;
rdfs:label "involved in or involved in regulation of" ;
rdfs:comment "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002328 , obo:RO_0002500 , obo:RO_0002264 .
obo:RO_0002436 a rdf:Property ;
rdfs:label "molecularly interacts with" ;
rdfs:comment "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002434 .
obo:RO_0002447 a rdf:Property ;
rdfs:label "phosphorylates" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002436 .
obo:RO_0002464 a rdf:Property ;
rdfs:label "helper property (not for use in curation)" ;
rdfs:range .
obo:RO_0002481 a rdf:Property ;
rdfs:label "is kinase activity" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002564 .
obo:RO_0002500 a rdf:Property ;
rdfs:label "causal agent in process" ;
rdfs:comment "A relationship between a material entity and a process where the material entity has some causal role that influences the process" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002595 .
obo:RO_0002502 a rdf:Property ;
rdfs:label "depends on" ;
rdfs:range .
obo:RO_0002559 a rdf:Property ;
rdfs:label "causally influenced by" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002506 .
obo:RO_0002563 a rdf:Property ;
rdfs:label "interaction relation helper property" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002464 .
obo:RO_0002564 a rdf:Property ;
rdfs:label "molecular interaction relation helper property" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002563 .
obo:RO_0002578 a rdf:Property ;
rdfs:label "directly regulates" ;
rdfs:comment "p directly regulates q iff p is immediately causally upstream of q and p regulates q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002412 , obo:RO_0002211 .
obo:RO_0002584 a rdf:Property ;
rdfs:label "has part structure that is capable of" ;
rdfs:comment "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002595 , obo:RO_0002328 .
obo:RO_0002596 a rdf:Property ;
rdfs:label "capable of regulating" ;
rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a regulates p." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002500 .
obo:RO_0002597 a rdf:Property ;
rdfs:label "capable of negatively regulating" ;
rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002596 .
obo:RO_0002598 a rdf:Property ;
rdfs:label "capable of positively regulating" ;
rdfs:comment "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002596 .
obo:RO_0002608 a rdf:Property ;
rdfs:label "process has causal agent" ;
rdfs:comment "Inverse of 'causal agent in process'" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002410 .
obo:RO_0002629 a rdf:Property ;
rdfs:label "directly positively regulates" ;
rdfs:comment "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002578 , obo:RO_0002213 .
obo:RO_0002630 a rdf:Property ;
rdfs:label "directly negatively regulates" ;
rdfs:comment "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002578 , obo:RO_0002212 .
obo:RO_0004031 a rdf:Property ;
rdfs:label "enables subfunction" ;
rdfs:comment "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002328 .
obo:RO_0004032 a rdf:Property ;
rdfs:label "acts upstream of or within, positive effect" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002264 .
obo:RO_0004033 a rdf:Property ;
rdfs:label "acts upstream of or within, negative effect" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002264 .
obo:RO_0004034 a rdf:Property ;
rdfs:label "acts upstream of, positive effect" ;
rdfs:comment "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0004032 , obo:RO_0002263 .
obo:RO_0004035 a rdf:Property ;
rdfs:label "acts upstream of, negative effect" ;
rdfs:comment "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0004033 , obo:RO_0002263 .
obo:RO_0004046 a rdf:Property ;
rdfs:label "causally upstream of or within, negative effect" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002418 .
obo:RO_0004047 a rdf:Property ;
rdfs:label "causally upstream of or within, positive effect" ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002418 .
obo:RO_0012011 a rdf:Property ;
rdfs:label "indirectly causally upstream of"@en ;
rdfs:comment "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0002411 .
obo:RO_0012012 a rdf:Property ;
rdfs:label "indirectly regulates"@en ;
rdfs:comment "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0012011 , obo:RO_0002211 .
obo:RO_0017001 a rdf:Property ;
rdfs:label "device utilizes material"@en ;
rdfs:comment "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." ;
rdfs:range .
obo:RO_0019001 a rdf:Property ;
rdfs:label "positively regulates characteristic" ;
rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0019000 .
obo:RO_0019002 a rdf:Property ;
rdfs:label "negatively regulates characteristic" ;
rdfs:comment "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." ;
rdfs:range xsd:string ;
rdfs:subPropertyOf obo:RO_0019000 .
obo:OBI_0002310 a rdfs:Class ;
rdfs:label "pathologic distant metastases stage for ovary according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002311 a obo:OBI_0002310 ;
rdfs:label "cM0 (ovary)" ;
rdfs:comment "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is no distant metastasis."@en .
obo:OBI_0002312 a obo:OBI_0002310 ;
rdfs:label "cM1 (ovary)" ;
rdfs:comment "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is distant metastasis except peritoneal metastasis based on clinical assessment."@en .
obo:OBI_0002313 a obo:OBI_0002310 ;
rdfs:label "pM1 (ovary)" ;
rdfs:comment "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is distant metastasis except peritoneal metastasis that is histologically confirmed."@en .
obo:OBI_0002314 a rdfs:Class ;
rdfs:label "clinical tumor stage group according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is an assessment of the stage of a cancer according to the American Joint Committee on Cancer (AJCC) v7 staging systems."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002315 a obo:OBI_0002314 ;
rdfs:label "Occult Carcinoma (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating a small carcinoma, either asymptomatic or giving rise to metastases without symptoms due to the primary carcinoma."@en .
obo:OBI_0002316 a obo:OBI_0002314 ;
rdfs:label "Stage 0 (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating a carcinoma in situ (or melanoma in situ for melanoma of the skin or germ cell neoplasia in situ for testicular germ cell tumors) and generally is considered to have no metastatic potential."@en .
obo:OBI_0002317 a obo:OBI_0002314 ;
rdfs:label "Stage I (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers that are smaller or less deeply invasive without regional disease or nodes."@en .
obo:OBI_0002318 a obo:OBI_0002314 ;
rdfs:label "Stage IIA (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIB and IIC."@en .
obo:OBI_0002319 a obo:OBI_0002314 ;
rdfs:label "Stage IIB (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIA and IIC."@en .
obo:OBI_0002320 a obo:OBI_0002314 ;
rdfs:label "Stage IIC (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIA and IIB."@en .
obo:OBI_0002321 a obo:OBI_0002314 ;
rdfs:label "Stage IIIA (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIB and IIIC."@en .
obo:OBI_0002322 a obo:OBI_0002314 ;
rdfs:label "Stage IIIB (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIA and IIIC."@en .
obo:OBI_0002323 a obo:OBI_0002314 ;
rdfs:label "Stage IIIC (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIA and IIIB."@en .
obo:OBI_0002324 a obo:OBI_0002314 ;
rdfs:label "Stage IVA (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers in patients who present with distant metastases at diagnosis and with differing characteristics from IVB."@en .
obo:OBI_0002325 a obo:OBI_0002314 ;
rdfs:label "Stage IVB (AJCC 7th)" ;
rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers in patients who present with distant metastases at diagnosis and with differing characteristics from IVA."@en .
obo:UO_0000051 a rdfs:Class ;
rdfs:label "concentration unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000062 a obo:UO_0000051 ;
rdfs:label "molar" ;
rdfs:comment "A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L)." .
obo:UO_0000063 a obo:UO_0000051 ;
rdfs:label "millimolar" ;
rdfs:comment "A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M." .
obo:UO_0000064 a obo:UO_0000051 ;
rdfs:label "micromolar" ;
rdfs:comment "A unit of molarity which is equal to one millionth of a molar or 10^[-6] M." .
obo:UO_0000065 a obo:UO_0000051 ;
rdfs:label "nanomolar" ;
rdfs:comment "A unit of molarity which is equal to one thousandth of one millionth of a molar or 10^[-9] M." .
obo:UO_0000066 a obo:UO_0000051 ;
rdfs:label "picomolar" ;
rdfs:comment "A unit of molarity which is equal to 10^[-12] M." .
obo:UO_0000163 a obo:UO_0000051 ;
rdfs:label "mass percentage" ;
rdfs:comment "A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture." .
obo:UO_0000164 a obo:UO_0000051 ;
rdfs:label "mass volume percentage" ;
rdfs:comment "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." .
obo:UO_0000165 a obo:UO_0000051 ;
rdfs:label "volume percentage" ;
rdfs:comment "A dimensionless concentration unit which denotes the volume of the solute in mL per 100 mL of the resulting solution." .
obo:UO_0000175 a obo:UO_0000051 ;
rdfs:label "gram per liter" ;
rdfs:comment "A mass unit density which is equal to mass of an object in grams divided by the volume in liters." .
obo:UO_0000176 a obo:UO_0000051 ;
rdfs:label "milligram per milliliter" ;
rdfs:comment "A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters." .
obo:UO_0000196 a obo:UO_0000051 ;
rdfs:label "pH" ;
rdfs:comment "A dimensionless concentration notation which denotes the acidity of a solution in terms of activity of hydrogen ions (H+)." .
obo:UO_0000207 a obo:UO_0000051 ;
rdfs:label "milliliter per liter" ;
rdfs:comment "A volume per unit volume unit which is equal to one millionth of a liter of solute in one liter of solution." .
obo:UO_0000208 a obo:UO_0000051 ;
rdfs:label "gram per deciliter" ;
rdfs:comment "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." .
obo:UO_0000212 a obo:UO_0000051 ;
rdfs:label "colony forming unit per volume" ;
rdfs:comment "A concentration unit which a measure of viable bacterial numbers in a given volume." .
obo:UO_0000301 a obo:UO_0000051 ;
rdfs:label "microgram per liter" ;
rdfs:comment "A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters." .
obo:OBI_0002341 a rdfs:Class ;
rdfs:label "International Federation of Gynecology and Obstetrics ovarian cancer stage value specification" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the FIGO classification system."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002342 a obo:OBI_0002341 ;
rdfs:label "Stage 1 (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1, N0, and M0."@en .
obo:OBI_0002343 a obo:OBI_0002341 ;
rdfs:label "Stage 1A (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1a, N0, and M0."@en .
obo:OBI_0002344 a obo:OBI_0002341 ;
rdfs:label "Stage 1B (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1b, N0, and M0."@en .
obo:OBI_0002345 a obo:OBI_0002341 ;
rdfs:label "Stage 1C (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1c, N0, and M0."@en .
obo:OBI_0002346 a obo:OBI_0002341 ;
rdfs:label "Stage 2 (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2, N0, and M0."@en .
obo:OBI_0002347 a obo:OBI_0002341 ;
rdfs:label "Stage 2A (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2a, N0, and M0."@en .
obo:OBI_0002348 a obo:OBI_0002341 ;
rdfs:label "Stage 2B (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2b, N0, and M0."@en .
obo:OBI_0002349 a obo:OBI_0002341 ;
rdfs:label "Stage 2C (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2c, N0, and M0."@en .
obo:OBI_0002350 a obo:OBI_0002341 ;
rdfs:label "Stage 3 (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T3, N0, and M0) or (T3,3a,3b, NX, and M0)."@en .
obo:OBI_0002351 a obo:OBI_0002341 ;
rdfs:label "Stage 3A (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T3a, N0, and M0 ."@en .
obo:OBI_0002352 a obo:OBI_0002341 ;
rdfs:label "Stage 3B (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T3b, N0, and M0 ."@en .
obo:OBI_0002353 a obo:OBI_0002341 ;
rdfs:label "Stage 3C (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T3c, N0,X and M0) or (any T, N1 and M0)."@en .
obo:OBI_0002354 a obo:OBI_0002341 ;
rdfs:label "Stage 4 (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of any T, any N, and M1."@en .
obo:OBI_0002355 a obo:OBI_0002341 ;
rdfs:label "Stage Unknown (FIGO)" ;
rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T0, N0, and M0) or (T1,1a-1c,2,2a-2c, NX, and M0) or (TX, N0,X, M0)."@en .
obo:OBI_0002287 a rdfs:Class ;
rdfs:label "pathologic lymph node stage for ovary according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002288 a obo:OBI_0002287 ;
rdfs:label "pN0 (ovary)" ;
rdfs:comment "A pathologic lymph node stage for ovary according to AJCC 7th edition indicating that there is no regional lymph node metastasis."@en .
obo:OBI_0002289 a obo:OBI_0002287 ;
rdfs:label "pN1 (ovary)" ;
rdfs:comment "A pathologic lymph node stage for ovary according to AJCC 7th edition indicating that there is regional lymph node metastasis."@en .
obo:UO_0000105 a rdfs:Class ;
rdfs:label "frequency unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000106 a obo:UO_0000105 ;
rdfs:label "hertz" ;
rdfs:comment "A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second." .
obo:OBI_0002224 a rdfs:Class ;
rdfs:label "pathologic primary tumor stage for colon and rectum according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002225 a obo:OBI_0002224 ;
rdfs:label "pT0 (colon)" ;
rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .
obo:OBI_0002226 a obo:OBI_0002224 ;
rdfs:label "pTis (colon)" ;
rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating carcinoma in situ (intraepithelial or invasion of lamina propria)."@en .
obo:OBI_0002227 a obo:OBI_0002224 ;
rdfs:label "pT1 (colon)" ;
rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades submucosa."@en .
obo:OBI_0002228 a obo:OBI_0002224 ;
rdfs:label "pT2 (colon)" ;
rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades muscularis propria."@en .
obo:OBI_0002229 a obo:OBI_0002224 ;
rdfs:label "pT3 (colon)" ;
rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades subserosa or into non-peritionealized pericolic or perirectal tissues."@en .
obo:OBI_0002230 a obo:OBI_0002224 ;
rdfs:label "pT4a (colon)" ;
rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor perforates visceral peritoneum."@en .
obo:OBI_0002231 a obo:OBI_0002224 ;
rdfs:label "pT4b (colon)" ;
rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor directly invades other organs or structures."@en .
obo:OBI_0002357 a rdfs:Class ;
rdfs:label "Eastern Cooperative Oncology Group score value specification" ;
rdfs:comment "A performance status value specification designed by the Eastern Cooperative Oncology Group to assess disease progression and its affect on the daily living abilities of the patient."@en ;
rdfs:subClassOf obo:OBI_0002356 .
obo:OBI_0002358 a obo:OBI_0002357 ;
rdfs:label "3: symptomatic in bed more than 50% of the day but not bed ridden" ;
rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic and in bed for more than 50% of the day but is not bed ridden."@en .
obo:OBI_0002359 a obo:OBI_0002357 ;
rdfs:label "2: symptomatic but in bed less than 50% of the day" ;
rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic but is in bed for less than 50% of the day."@en .
obo:OBI_0002360 a obo:OBI_0002357 ;
rdfs:label "4: bed ridden" ;
rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic and is bed ridden."@en .
obo:OBI_0002361 a obo:OBI_0002357 ;
rdfs:label "0: asymptomatic" ;
rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is asymptomatic."@en .
obo:OBI_0002362 a obo:OBI_0002357 ;
rdfs:label "1: symptomatic but fully ambulatory" ;
rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic but is fully ambulatory."@en .
obo:OBI_0002290 a rdfs:Class ;
rdfs:label "pathologic distant metastases stage for colon according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of colon cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002291 a obo:OBI_0002290 ;
rdfs:label "cM0 (colon)" ;
rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there are no symptoms or signs of distant metastasis."@en .
obo:OBI_0002292 a obo:OBI_0002290 ;
rdfs:label "cM1 (colon)" ;
rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there is clinical evidence of distant metastases by history, physical examination, imaging studies, or invasive procedures, but without microscopic evidence of the presumed distant metastases."@en .
obo:OBI_0002293 a obo:OBI_0002290 ;
rdfs:label "cM1a (colon)" ;
rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is confined to one organ based on clinical assessment."@en .
obo:OBI_0002294 a obo:OBI_0002290 ;
rdfs:label "cM1b (colon)" ;
rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is in more than one organ or the peritoneum based on clinical assessment."@en .
obo:OBI_0002295 a obo:OBI_0002290 ;
rdfs:label "pM1 (colon)" ;
rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there is microscopic evidence confirming distant metastatic disease."@en .
obo:OBI_0002296 a obo:OBI_0002290 ;
rdfs:label "pM1a (colon)" ;
rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is confined to one organ and histologically confirmed."@en .
obo:OBI_0002297 a obo:OBI_0002290 ;
rdfs:label "pM1b (colon)" ;
rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is in more than one organ or the peritoneum and histologically confirmed."@en .
obo:UO_0000005 a rdfs:Class ;
rdfs:label "temperature unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000027 a obo:UO_0000005 ;
rdfs:label "degree Celsius" ;
rdfs:comment "A temperature unit which is equal to one kelvin degree. However, they have their zeros at different points. The centigrade scale has its zero at 273.15 K." .
obo:UO_0000195 a obo:UO_0000005 ;
rdfs:label "degree Fahrenheit" ;
rdfs:comment "A temperature unit which is equal to 5/9ths of a kelvin. Negative 40 degrees Fahrenheit is equal to negative 40 degrees Celsius." .
obo:OBI_0000963 a rdfs:Class ;
rdfs:label "categorical label" ;
rdfs:comment "A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale."@en ;
rdfs:subClassOf obo:IAO_0000009 .
obo:OBI_0000958 a obo:OBI_0000963 ;
rdfs:label "right handed" .
obo:OBI_0000979 a obo:OBI_0000963 ;
rdfs:label "ambidexterous" .
obo:OBI_0000998 a obo:OBI_0000963 ;
rdfs:label "left handed" .
obo:OBI_0002279 a rdfs:Class ;
rdfs:label "pathologic lymph node stage for lung according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002280 a obo:OBI_0002279 ;
rdfs:label "pN0 (lung)" ;
rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating no regional lymph node metastasis."@en .
obo:OBI_0002281 a obo:OBI_0002279 ;
rdfs:label "pN1 (lung)" ;
rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension."@en .
obo:OBI_0002282 a obo:OBI_0002279 ;
rdfs:label "pN2 (lung)" ;
rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in ipsilateral mediastinal and/or subcarinal lymph node(s)."@en .
obo:OBI_0002283 a obo:OBI_0002279 ;
rdfs:label "pN3 (lung)" ;
rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)."@en .
obo:OBI_0002219 a rdfs:Class ;
rdfs:label "histologic grade for ovarian tumor according to the World Health Organization" ;
rdfs:comment "A histologic grade for ovarian tumor that is from a histological classification by the World Health Organization (WHO)."@en ;
rdfs:subClassOf obo:OBI_0002215 .
obo:OBI_0002220 a obo:OBI_0002219 ;
rdfs:label "G1 (WHO)" ;
rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is well differentiated."@en .
obo:OBI_0002221 a obo:OBI_0002219 ;
rdfs:label "G2 (WHO)" ;
rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is moderately differentiated."@en .
obo:OBI_0002222 a obo:OBI_0002219 ;
rdfs:label "G3 (WHO)" ;
rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is poorly differentiated."@en .
obo:OBI_0002223 a obo:OBI_0002219 ;
rdfs:label "G4 (WHO)" ;
rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is undifferentiated."@en .
obo:OBI_0002306 a rdfs:Class ;
rdfs:label "pathologic distant metastases stage for kidney according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002307 a obo:OBI_0002306 ;
rdfs:label "cM0 (kidney)" ;
rdfs:comment "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there is no distant metastasis."@en .
obo:OBI_0002308 a obo:OBI_0002306 ;
rdfs:label "cM1 (kidney)" ;
rdfs:comment "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there are distant metastases based on clinical assessment."@en .
obo:OBI_0002309 a obo:OBI_0002306 ;
rdfs:label "pM1 (kidney)" ;
rdfs:comment "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed."@en .
obo:OBI_0002243 a rdfs:Class ;
rdfs:label "pathologic primary tumor stage for kidney according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002244 a obo:OBI_0002243 ;
rdfs:label "pT0 (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .
obo:OBI_0002245 a obo:OBI_0002243 ;
rdfs:label "pT1 (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is 7 cm or less in greatest dimension and limited to the kidney."@en .
obo:OBI_0002246 a obo:OBI_0002243 ;
rdfs:label "pT1a (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is 4 cm or less."@en .
obo:OBI_0002247 a obo:OBI_0002243 ;
rdfs:label "pT1b (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 4 cm but not more than 7 cm."@en .
obo:OBI_0002248 a obo:OBI_0002243 ;
rdfs:label "pT2 (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 7 cm in greatest dimension and limited to the kidney."@en .
obo:OBI_0002249 a obo:OBI_0002243 ;
rdfs:label "pT2a (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 7 cm but not more than 10 cm."@en .
obo:OBI_0002250 a obo:OBI_0002243 ;
rdfs:label "pT2b (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 10 cm and limited to the kidney."@en .
obo:OBI_0002251 a obo:OBI_0002243 ;
rdfs:label "pT3 (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor extends into major veins or perinephric tissues but not into the ipsilateral adrenal gland and not beyond the Gerota fascia."@en .
obo:OBI_0002252 a obo:OBI_0002243 ;
rdfs:label "pT3a (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into the renal vein or its segmental (muscle containing) branches, or the tumor invades perirenal and/or renal sinus fat (peripelvic) fat but not beyond Gerota fascia."@en .
obo:OBI_0002253 a obo:OBI_0002243 ;
rdfs:label "pT3b (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into vena cava below diaphragm."@en .
obo:OBI_0002254 a obo:OBI_0002243 ;
rdfs:label "pT3c (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into vena cava above the diaphragm or Invades the wall of the vena cava."@en .
obo:OBI_0002255 a obo:OBI_0002243 ;
rdfs:label "pT4 (kidney)" ;
rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor invades beyond Gerota fascia (including contiguous extension into the ipsilateral adrenal gland)."@en .
obo:UO_0000280 a rdfs:Class ;
rdfs:label "rate unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000281 a obo:UO_0000280 ;
rdfs:label "count per nanomolar second" ;
rdfs:comment "A rate unit which is equal to one over one nanomolar second." .
obo:UO_0000282 a obo:UO_0000280 ;
rdfs:label "count per molar second" ;
rdfs:comment "A rate unit which is equal to one over one molar second." .
obo:UO_0000284 a obo:UO_0000280 ;
rdfs:label "count per nanomolar" ;
rdfs:comment "A rate unit which is equal to one over one nanomolar." .
obo:UO_0000285 a obo:UO_0000280 ;
rdfs:label "count per molar" ;
rdfs:comment "A rate unit which is equal to one over one molar." .
obo:UO_0000006 a rdfs:Class ;
rdfs:label "substance unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000039 a obo:UO_0000006 ;
rdfs:label "micromole" ;
rdfs:comment "A substance unit equal to a millionth of a mol or 10^[-6] mol." .
obo:UO_0000041 a obo:UO_0000006 ;
rdfs:label "nanomole" ;
rdfs:comment "A substance unit equal to one thousandth of one millionth of a mole or 10^[-9] mol." .
obo:UO_0000042 a obo:UO_0000006 ;
rdfs:label "picomole" ;
rdfs:comment "A substance unit equal to 10^[-12] mol." .
obo:IAO_0000409 a rdfs:Class ;
rdfs:label "denotator type"@en ;
rdfs:comment "A denotator type indicates how a term should be interpreted from an ontological perspective."@en ;
rdfs:subClassOf obo:IAO_0000102 .
obo:IAO_0000410 a obo:IAO_0000409 ;
rdfs:label "universal"@en .
obo:IAO_0000420 a obo:IAO_0000409 ;
rdfs:label "defined class"@en ;
rdfs:comment "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en .
obo:IAO_0000421 a obo:IAO_0000409 ;
rdfs:label "named class expression"@en ;
rdfs:comment "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en .
obo:OBI_0002216 a rdfs:Class ;
rdfs:label "histologic grade for ovarian tumor according to a two-tier grading system" ;
rdfs:comment "A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors."@en ;
rdfs:subClassOf obo:OBI_0002215 .
obo:OBI_0002217 a obo:OBI_0002216 ;
rdfs:label "Low grade ovarian tumor" ;
rdfs:comment "A histologic grade for ovarian tumor according to a two-tier grading system indicating that the tumor is low grade."@en .
obo:OBI_0002218 a obo:OBI_0002216 ;
rdfs:label "High grade ovarian tumor" ;
rdfs:comment "A histologic grade for ovarian tumor according to a two-tier grading system indicating that the tumor is high grade."@en .
obo:OBI_0000713 a rdfs:Class ;
rdfs:label "GenePattern software" ;
rdfs:comment "a software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks."@en ;
rdfs:subClassOf obo:IAO_0000010 .
obo:OBI_0000761 a obo:OBI_0000713 ;
rdfs:label "GenePattern module SVM" ;
rdfs:comment "GenePattern module SVM is a GenePattern software module which is used to run a support vector machine data transformation."@en .
obo:OBI_0000766 a obo:OBI_0000713 ;
rdfs:label "GenePattern module KMeansClustering" ;
rdfs:comment "GenePattern module KMeansClustering is a GenePattern software module which is used to perform a k Means clustering data transformation."@en .
obo:OBI_0000768 a obo:OBI_0000713 ;
rdfs:label "GenePattern module CARTXValidation" ;
rdfs:comment "GenePattern module CARTXValidation is a GenePattern software module which uses a CART decision tree induction with a leave one out cross validation data transformations."@en .
obo:OBI_0000771 a obo:OBI_0000713 ;
rdfs:label "GenePattern module KNNXValidation" ;
rdfs:comment "GenePattern module KNNXValidation is a GenePattern software module which uses a k-nearest neighbours clustering with a leave one out cross validation data transformations."@en .
obo:OBI_0000772 a obo:OBI_0000713 ;
rdfs:label "GenePattern module PeakMatch" .
obo:OBI_0000773 a obo:OBI_0000713 ;
rdfs:label "GenePattern module KNN" ;
rdfs:comment "GenePattern module KNN is a GenePattern software module which perform a k-nearest neighbors data transformation."@en .
obo:OBI_0000774 a obo:OBI_0000713 ;
rdfs:label "GenePattern module HierarchicalClustering" ;
rdfs:comment "GenePattern module HierarchicalClustering is a GenePattern software module which is used to perform a hierarchical clustering data transformation."@en .
obo:OBI_0000777 a obo:OBI_0000713 ;
rdfs:label "GenePattern module PCA" ;
rdfs:comment "GenePattern module PCA is a GenePattern software module which is used to perform a principal components analysis dimensionality reduction data transformation."@en .
obo:OBI_0000782 a obo:OBI_0000713 ;
rdfs:label "GenePattern module HeatMapViewer" ;
rdfs:comment "A GenePattern software module which is used to generate a heatmap view of data."@en .
obo:OBI_0000783 a obo:OBI_0000713 ;
rdfs:label "GenePattern module HierarchicalClusteringViewer" ;
rdfs:comment "A GenePattern software module which is used to generate a view of data that has been hierarchically clustered."@en .
obo:OBI_0002205 a rdfs:Class ;
rdfs:label "histologic grade according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the American Joint Committee on Cancer (AJCC) 7th Edition grading system."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002206 a obo:OBI_0002205 ;
rdfs:label "G1: Well differentiated" ;
rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells and the organization of the tumor tissue appear close to normal."@en .
obo:OBI_0002207 a obo:OBI_0002205 ;
rdfs:label "G2: Moderately differentiated" ;
rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells are moderately differentiated and reflect an intermediate grade."@en .
obo:OBI_0002208 a obo:OBI_0002205 ;
rdfs:label "G3: Poorly differentiated" ;
rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells are poorly differentiated and do not look like normal cells and tissue."@en .
obo:OBI_0002209 a obo:OBI_0002205 ;
rdfs:label "G4: Undifferentiated" ;
rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells are undifferentiated and do not look like normal cells and tissue."@en .
obo:UO_0000003 a rdfs:Class ;
rdfs:label "time unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000010 a obo:UO_0000003 ;
rdfs:label "second" ;
rdfs:comment "A time unit which is equal to the duration of 9 192 631 770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom." .
obo:UO_0000031 a obo:UO_0000003 ;
rdfs:label "minute" ;
rdfs:comment "A time unit which is equal to 60 seconds." .
obo:UO_0000032 a obo:UO_0000003 ;
rdfs:label "hour" ;
rdfs:comment "A time unit which is equal to 3600 seconds or 60 minutes." .
obo:UO_0000033 a obo:UO_0000003 ;
rdfs:label "day" ;
rdfs:comment "A time unit which is equal to 24 hours." .
obo:UO_0000034 a obo:UO_0000003 ;
rdfs:label "week" ;
rdfs:comment "A time unit which is equal to 7 days." .
obo:UO_0000035 a obo:UO_0000003 ;
rdfs:label "month" ;
rdfs:comment "A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days." .
obo:UO_0000036 a obo:UO_0000003 ;
rdfs:label "year" ;
rdfs:comment "A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days." .
obo:OBI_0002270 a rdfs:Class ;
rdfs:label "pathologic lymph node stage for colon and rectum according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002271 a obo:OBI_0002270 ;
rdfs:label "pN0 (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating no regional lymph node metastsis."@en .
obo:OBI_0002272 a obo:OBI_0002270 ;
rdfs:label "pN1 (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 1-3 regional lymph nodes."@en .
obo:OBI_0002273 a obo:OBI_0002270 ;
rdfs:label "pN1a (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 1 regional lymph node."@en .
obo:OBI_0002274 a obo:OBI_0002270 ;
rdfs:label "pN1b (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 2-3 regional lymph nodes."@en .
obo:OBI_0002275 a obo:OBI_0002270 ;
rdfs:label "pN1c (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating tumor deposit(s), i.e., satellites in the subserosa, or in non-peritonealized pericolic or perirectal soft tissue without regional lymph node metastasis."@en .
obo:OBI_0002276 a obo:OBI_0002270 ;
rdfs:label "pN2 (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 4 or more regional lymph nodes."@en .
obo:OBI_0002277 a obo:OBI_0002270 ;
rdfs:label "pN2a (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 4 to 6 regional lymph nodes."@en .
obo:OBI_0002278 a obo:OBI_0002270 ;
rdfs:label "pN2b (colon)" ;
rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 7 or more regional lymph nodes."@en .
obo:IAO_0000098 a rdfs:Class ;
rdfs:label "data format specification"@en ;
rdfs:comment """A data format specification is the information content borne by the document published defining the specification.
Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file"""@en ;
rdfs:subClassOf obo:IAO_0000033 .
obo:OBI_0000317 a obo:IAO_0000098 ;
rdfs:label "Transformation-ML"@en ;
rdfs:comment "Transformation-ML is a format standard of a digital entity that is conformant with the Transformation-ML standard.(http://wiki.ficcs.org/ficcs/Transformation-ML?action=AttachFile&do=get&target=Transformation-ML_v1.0.26.pdf)"@en .
obo:OBI_0000321 a obo:IAO_0000098 ;
rdfs:label "ACS"@en ;
rdfs:comment "ACS is a format standard of a digital entity that is conformant with the Analytical Cytometry Standard. (http://www.isac-net.org/content/view/607/150/)"@en .
obo:OBI_0000322 a obo:IAO_0000098 ;
rdfs:label "XML"@en ;
rdfs:comment "XML is a format standard of a digital entity that is conformant with the W3C Extensible Markup Language Recommendation.(http://www.w3.org/XML/)"@en .
obo:OBI_0000324 a obo:IAO_0000098 ;
rdfs:label "RDF"@en ;
rdfs:comment "RDF is a format standard of a digital entity that is conformant with the W3C Resource Description Framework RDF/XML Syntax specification.(http://www.w3.org/RDF/)"@en .
obo:OBI_0000325 a obo:IAO_0000098 ;
rdfs:label "zip"@en ;
rdfs:comment "zip is a format standard of a digital entity that is conformant with the PKWARE .ZIP file format specification (http://www.pkware.com/index.php?option=com_content&task=view&id=59&Itemid=103/)"@en .
obo:OBI_0000326 a obo:IAO_0000098 ;
rdfs:label "tar"@en ;
rdfs:comment "tar is a format standard of a digital entity that is conformant with the tape archive file format as standardized by POSIX.1-1998, POSIX.1-2001, or any other tar format compliant with the GNU tar specification. (http://www.gnu.org/software/tar/manual/)"@en .
obo:OBI_0000327 a obo:IAO_0000098 ;
rdfs:label "FCS"@en ;
rdfs:comment "FCS is a format standard of a digital entity that is conformant with the Flow Cytometry Data File Standard.(http://www.fcspress.com/)"@en .
obo:OBI_0000329 a obo:IAO_0000098 ;
rdfs:label "Compensation-ML"@en ;
rdfs:comment "Compensation-ML is a format standard of a digital entity that is conformant with the Compensation-ML standard. (http://wiki.ficcs.org/ficcs/Compensation-ML?action=AttachFile&do=get&target=Compensation-ML_v1.0.24.pdf)"@en .
obo:OBI_0000330 a obo:IAO_0000098 ;
rdfs:label "Gating-ML"@en ;
rdfs:comment "Gating-ML is a format standard of a digital entity that is conformant with the Gating-ML standard. (http://www.flowcyt.org/gating/)"@en .
obo:OBI_0000332 a obo:IAO_0000098 ;
rdfs:label "OWL"@en ;
rdfs:comment "OWL is a format standard of a digital entity that is conformant with the W3C Web Ontology Language specification.(http://www.w3.org/2004/OWL/)"@en .
obo:OBI_0002298 a rdfs:Class ;
rdfs:label "pathologic distant metastases stage for lung according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002299 a obo:OBI_0002298 ;
rdfs:label "cM0 (lung)" ;
rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is no distant metastasis."@en .
obo:OBI_0002300 a obo:OBI_0002298 ;
rdfs:label "cM1 (lung)" ;
rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there are distant metastases based on clinical assessment."@en .
obo:OBI_0002301 a obo:OBI_0002298 ;
rdfs:label "cM1a (lung)" ;
rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that metastasis is based on clinical assessment and a separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules OR malignant pleural or pericardial effusion."@en .
obo:OBI_0002302 a obo:OBI_0002298 ;
rdfs:label "cM1b (lung)" ;
rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases based on clinical assessment."@en .
obo:OBI_0002303 a obo:OBI_0002298 ;
rdfs:label "pM1 (lung)" ;
rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed."@en .
obo:OBI_0002304 a obo:OBI_0002298 ;
rdfs:label "pM1a (lung)" ;
rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that metastasis is histologically confirmed and a separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules OR malignant pleural or pericardial effusion."@en .
obo:OBI_0002305 a obo:OBI_0002298 ;
rdfs:label "pM1b (lung)" ;
rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed and associated with distant lymph nodes or carcinomatosis."@en .
obo:UO_0000095 a rdfs:Class ;
rdfs:label "volume unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000097 a obo:UO_0000095 ;
rdfs:label "cubic centimeter" ;
rdfs:comment "A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml." .
obo:UO_0000098 a obo:UO_0000095 ;
rdfs:label "milliliter" ;
rdfs:comment "A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter." .
obo:UO_0000099 a obo:UO_0000095 ;
rdfs:label "liter" ;
rdfs:comment "A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter." .
obo:UO_0000100 a obo:UO_0000095 ;
rdfs:label "cubic decimeter" ;
rdfs:comment "A volume unit which is equal to one thousand of a cubic meter or 10^[-3] m^[3], or to 1 L." .
obo:UO_0000101 a obo:UO_0000095 ;
rdfs:label "microliter" ;
rdfs:comment "A volume unit which is equal to one millionth of a liter or 10^[-6] L." .
obo:UO_0000102 a obo:UO_0000095 ;
rdfs:label "nanoliter" ;
rdfs:comment "A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L." .
obo:UO_0000103 a obo:UO_0000095 ;
rdfs:label "picoliter" ;
rdfs:comment "A volume unit which is equal to 10^[-12] L." .
obo:OBI_0001000 a rdfs:Class ;
rdfs:label "questionnaire" ;
rdfs:comment "A document with a set of printed or written questions with a choice of answers, devised for the purposes of a survey or statistical study."@en ;
rdfs:subClassOf obo:IAO_0000310 .
obo:OBI_0001004 a obo:OBI_0001000 ;
rdfs:label "Edingburgh handedness inventory" ;
rdfs:comment "The Edinburgh Handedness Inventory is a set of questions used to assess the dominance of a person's right or left hand in everyday activities."@en .
obo:UO_0000001 a rdfs:Class ;
rdfs:label "length unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000008 a obo:UO_0000001 ;
rdfs:label "meter" ;
rdfs:comment "A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second." .
obo:UO_0000015 a obo:UO_0000001 ;
rdfs:label "centimeter" ;
rdfs:comment "A length unit which is equal to one hundredth of a meter or 10^[-2] m." .
obo:UO_0000016 a obo:UO_0000001 ;
rdfs:label "millimeter" ;
rdfs:comment "A length unit which is equal to one thousandth of a meter or 10^[-3] m." .
obo:UO_0000017 a obo:UO_0000001 ;
rdfs:label "micrometer" ;
rdfs:comment "A length unit which is equal to one millionth of a meter or 10^[-6] m." .
obo:UO_0000018 a obo:UO_0000001 ;
rdfs:label "nanometer" ;
rdfs:comment "A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m." .
obo:UO_0000019 a obo:UO_0000001 ;
rdfs:label "angstrom" ;
rdfs:comment "A length unit which is equal to 10 [-10] m." .
obo:OBI_0200051 a rdfs:Class ;
rdfs:label "principal components analysis dimensionality reduction"@en ;
rdfs:comment "A principal components analysis dimensionality reduction is a dimensionality reduction achieved by applying principal components analysis and by keeping low-order principal components and excluding higher-order ones."@en ;
rdfs:subClassOf obo:OBI_0200050 .
obo:OBI_0000760 a obo:OBI_0200051 ;
rdfs:label "GenePattern PCA" .
obo:OBI_0002326 a rdfs:Class ;
rdfs:label "International Federation of Gynecology and Obstetrics cervical cancer stage value specification" ;
rdfs:comment "A categorical value specification that is an assessment of the stage of a gynecologic cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging systems."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002327 a obo:OBI_0002326 ;
rdfs:label "Stage IA (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating invasive carcinoma which can be diagnosed only by microscopy, with deepest invasion <5 mm and the largest extension <7 mm."@en .
obo:OBI_0002328 a obo:OBI_0002326 ;
rdfs:label "Stage IA1 (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating measured stromal invasion of <3.0 mm in depth and extension of <7.0 mm."@en .
obo:OBI_0002329 a obo:OBI_0002326 ;
rdfs:label "Stage IA2 (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating measured stromal invasion of >3.0 mm and not >5.0 mm with an extension of not >7.0 mm."@en .
obo:OBI_0002330 a obo:OBI_0002326 ;
rdfs:label "Stage IB (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesions limited to the cervix uteri or pre-clinical cancers greater than stage IA"@en .
obo:OBI_0002331 a obo:OBI_0002326 ;
rdfs:label "Stage IB1 (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesion limited to the cervix uteri or pre-clinical cancers greater than stage IA <4.0 cm in greatest dimension."@en .
obo:OBI_0002332 a obo:OBI_0002326 ;
rdfs:label "Stage IB2 (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesion limited to the cervix uteri or pre-clinical cancers greater than stage IA >4.0 cm in greatest dimension."@en .
obo:OBI_0002333 a obo:OBI_0002326 ;
rdfs:label "Stage IIA (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion."@en .
obo:OBI_0002334 a obo:OBI_0002326 ;
rdfs:label "Stage IIA1 (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion <4.0 cm in greatest dimension."@en .
obo:OBI_0002335 a obo:OBI_0002326 ;
rdfs:label "Stage IIA2 (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion >4.0 cm in greatest dimension."@en .
obo:OBI_0002336 a obo:OBI_0002326 ;
rdfs:label "Stage IIB (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina with obvious parametrial invasion."@en .
obo:OBI_0002337 a obo:OBI_0002326 ;
rdfs:label "Stage IIIA (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating tumour involves lower third of the vagina, with no extension to the pelvic wall."@en .
obo:OBI_0002338 a obo:OBI_0002326 ;
rdfs:label "Stage IIIB (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating extension to the pelvic wall and/or hydronephrosis or non-functioning kidney."@en .
obo:OBI_0002339 a obo:OBI_0002326 ;
rdfs:label "Stage IVA (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating spread of the growth to adjacent organs."@en .
obo:OBI_0002340 a obo:OBI_0002326 ;
rdfs:label "Stage IVB (FIGO)" ;
rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating spread to distant organs."@en .
obo:OBI_0002284 a rdfs:Class ;
rdfs:label "pathologic lymph node stage for kidney according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002285 a obo:OBI_0002284 ;
rdfs:label "pN0 (kidney)" ;
rdfs:comment "A pathologic lymph node stage for kidney according to AJCC 7th edition indicating that there is no regional lymph node metastasis."@en .
obo:OBI_0002286 a obo:OBI_0002284 ;
rdfs:label "pN1 (kidney)" ;
rdfs:comment "A pathologic lymph node stage for kidney according to AJCC 7th edition indicating that there is regional lymph node metastasis."@en .
obo:OBI_0000726 a rdfs:Class ;
rdfs:label "peak matching" ;
rdfs:comment "Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold"@en ;
rdfs:subClassOf obo:OBI_0200000 .
obo:OBI_0000778 a obo:OBI_0000726 ;
rdfs:label "GenePattern peak matching" .
obo:OBI_0002363 a rdfs:Class ;
rdfs:label "Karnofsky score vaue specification" ;
rdfs:comment "A performance status value specification designed for classifying patients 16 years of age or older by their functional impairment."@en ;
rdfs:subClassOf obo:OBI_0002356 .
obo:OBI_0002364 a obo:OBI_0002363 ;
rdfs:label "100: asymptomatic" ;
rdfs:comment "A Karnofsky score vaue specification indicating that a patient is asymptomatic."@en .
obo:OBI_0002365 a obo:OBI_0002363 ;
rdfs:label "80-90: symptomatic but fully ambulatory" ;
rdfs:comment "A Karnofsky score vaue specification indicating that a patient is symptomatic but fully ambulatory."@en .
obo:OBI_0002366 a obo:OBI_0002363 ;
rdfs:label "60-70: symptomatic but in bed less than 50% of the day" ;
rdfs:comment "A Karnofsky score vaue specification indicating that a patient is symptomatic but in bed less than 50% of the day."@en .
obo:OBI_0002367 a obo:OBI_0002363 ;
rdfs:label "40-50: symptomatic, in bed more than 50% of the day, but not bed ridden" ;
rdfs:comment "A Karnofsky score vaue specification indicating that a patient is symptomatic, in bed more than 50% of the day, but not bed ridden."@en .
obo:UO_0000270 a rdfs:Class ;
rdfs:label "volumetric flow rate unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000271 a obo:UO_0000270 ;
rdfs:label "microliters per minute" ;
rdfs:comment "A volumetric flow rate unit which is equal to one microliter volume through a given surface in one minute." .
obo:OBI_0000749 a rdfs:Class ;
rdfs:label "CART"@en ;
rdfs:comment "A CART (classification and regression trees) is a data transformation method for producing a classification or regression model with a tree-based structure."@en ;
rdfs:subClassOf obo:OBI_0000707 .
obo:OBI_0000767 a obo:OBI_0000749 ;
rdfs:label "GenePattern CART" .
obo:OBI_0002210 a rdfs:Class ;
rdfs:label "histologic grade according to the Fuhrman Nuclear Grading System" ;
rdfs:comment "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the Fuhrman Nuclear Grading System."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002211 a obo:OBI_0002210 ;
rdfs:label "G1 (Fuhrman)" ;
rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are round, uniform, approximately 10um and that nucleoli are inconspicuous or absent."@en .
obo:OBI_0002212 a obo:OBI_0002210 ;
rdfs:label "G2 (Fuhrman)" ;
rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are slightly irregular, approximately 15um and nucleoli are evident."@en .
obo:OBI_0002213 a obo:OBI_0002210 ;
rdfs:label "G3 (Fuhrman)" ;
rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are very irregular, approximately 20um and nucleoli large and prominent."@en .
obo:OBI_0002214 a obo:OBI_0002210 ;
rdfs:label "G4 (Fuhrman)" ;
rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei arei bizarre and multilobulated, 20um or greater and nucleoli are prominent and chromatin clumped."@en .
obo:UO_0000002 a rdfs:Class ;
rdfs:label "mass unit" ;
rdfs:subClassOf obo:IAO_0000003 .
obo:UO_0000009 a obo:UO_0000002 ;
rdfs:label "kilogram" ;
rdfs:comment "A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France." .
obo:UO_0000021 a obo:UO_0000002 ;
rdfs:label "gram" ;
rdfs:comment "A mass unit which is equal to one thousandth of a kilogram or 10^[-3] kg." .
obo:UO_0000022 a obo:UO_0000002 ;
rdfs:label "milligram" ;
rdfs:comment "A mass unit which is equal to one thousandth of a gram or 10^[-3] g." .
obo:UO_0000023 a obo:UO_0000002 ;
rdfs:label "microgram" ;
rdfs:comment "A mass unit which is equal to one millionth of a gram or 10^[-6] g." .
obo:UO_0000024 a obo:UO_0000002 ;
rdfs:label "nanogram" ;
rdfs:comment "A mass unit which is equal to one thousandth of one millionth of a gram or 10^[-9] g." .
obo:UO_0000025 a obo:UO_0000002 ;
rdfs:label "picogram" ;
rdfs:comment "A mass unit which is equal to 10^[-12] g." .
obo:OBI_0200033 a rdfs:Class ;
rdfs:label "leave one out cross validation method"@en ;
rdfs:comment "is a data transformation : leave-one-out cross-validation (LOOCV) involves using a single observation from the original sample as the validation data, and the remaining observations as the training data. This is repeated such that each observation in the sample is used once as the validation data"@en ;
rdfs:subClassOf obo:OBI_0000792 .
obo:OBI_0000763 a obo:OBI_0200033 ;
rdfs:label "GenePattern LOOCV" .
obo:IAO_0000225 a rdfs:Class ;
rdfs:label "obsolescence reason specification"@en ;
rdfs:comment "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
rdfs:subClassOf obo:IAO_0000102 .
obo:IAO_0000103 a obo:IAO_0000225 ;
rdfs:label "failed exploratory term"@en ;
rdfs:comment "The term was initially used in an attempt to structure part of the ontology, but in retrospect failed to do a good job."@en .
obo:IAO_0000226 a obo:IAO_0000225 ;
rdfs:label "placeholder removed"@en ;
rdfs:comment "The term was created to temporarily stand in for a semantic purpose, but is no longer needed, typically due to another permanent term being defined."@en .
obo:IAO_0000227 a obo:IAO_0000225 ;
rdfs:label "terms merged"@en ;
rdfs:comment "The term has been combined with one or more other terms to create a more encompassing (merged) term."@en .
obo:IAO_0000228 a obo:IAO_0000225 ;
rdfs:label "term imported"@en ;
rdfs:comment "The term has been replaced by a term imported from another ontology."@en .
obo:IAO_0000229 a obo:IAO_0000225 ;
rdfs:label "term split"@en ;
rdfs:comment "The term has been split into two or more new terms."@en .
obo:OMO_0001000 a obo:IAO_0000225 ;
rdfs:label "out of scope" ;
rdfs:comment "The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not."@en .
obo:IAO_0000078 a rdfs:Class ;
rdfs:label "curation status specification"@en ;
rdfs:comment "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
rdfs:subClassOf obo:IAO_0000102 .
obo:IAO_0000002 a obo:IAO_0000078 ;
rdfs:label "example to be eventually removed"@en .
obo:IAO_0000120 a obo:IAO_0000078 ;
rdfs:label "metadata complete"@en ;
rdfs:comment "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en .
obo:IAO_0000121 a obo:IAO_0000078 ;
rdfs:label "organizational term"@en ;
rdfs:comment "The term was created to ease viewing/sorting terms for development purposes, but will not be included in a release."@en .
obo:IAO_0000122 a obo:IAO_0000078 ;
rdfs:label "ready for release"@en ;
rdfs:comment "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""@en .
obo:IAO_0000123 a obo:IAO_0000078 ;
rdfs:label "metadata incomplete"@en ;
rdfs:comment "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en .
obo:IAO_0000124 a obo:IAO_0000078 ;
rdfs:label "uncurated"@en ;
rdfs:comment "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en .
obo:IAO_0000125 a obo:IAO_0000078 ;
rdfs:label "pending final vetting"@en ;
rdfs:comment "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en .
obo:IAO_0000423 a obo:IAO_0000078 ;
rdfs:label "to be replaced with external ontology term"@en ;
rdfs:comment "Terms with this status should eventually replaced with a term from another ontology."@en .
obo:IAO_0000428 a obo:IAO_0000078 ;
rdfs:label "requires discussion"@en ;
rdfs:comment "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en .
obo:OBI_0002256 a rdfs:Class ;
rdfs:label "pathologic primary tumor stage for ovary according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002257 a obo:OBI_0002256 ;
rdfs:label "pT0 (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .
obo:OBI_0002258 a obo:OBI_0002256 ;
rdfs:label "pT1 (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to the ovaries (one or both)."@en .
obo:OBI_0002259 a obo:OBI_0002256 ;
rdfs:label "pT1a (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to one ovary; capsule intact, no tumor on ovarian surface and no malignant cells in ascites or peritoneal washings."@en .
obo:OBI_0002260 a obo:OBI_0002256 ;
rdfs:label "pT1b (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to both ovaries; capsule intact, no tumor on ovarian surface and no malignant cells in ascites or peritoneal washings."@en .
obo:OBI_0002261 a obo:OBI_0002256 ;
rdfs:label "pT1c (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to one or both ovaries with capsule ruptured, tumor on ovarian surface, or malignant cells in ascites or peritoneal washings."@en .
obo:OBI_0002262 a obo:OBI_0002256 ;
rdfs:label "pT2 (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor involves one or both ovaries with pelvic extension."@en .
obo:OBI_0002263 a obo:OBI_0002256 ;
rdfs:label "pT2a (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has extension and/or implants on uterus and/or tube(s) and no malignant cells in ascites or peritoneal washings."@en .
obo:OBI_0002264 a obo:OBI_0002256 ;
rdfs:label "pT2b (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has extension to other pelvic tissues and no malignant cells in ascites or peritoneal washings."@en .
obo:OBI_0002265 a obo:OBI_0002256 ;
rdfs:label "pT2c (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has pelvic extension with malignant cells in ascites or peritoneal washings."@en .
obo:OBI_0002266 a obo:OBI_0002256 ;
rdfs:label "pT3 (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis and/or regional lymph node metastasis."@en .
obo:OBI_0002267 a obo:OBI_0002256 ;
rdfs:label "pT3a (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has microscopic peritoneal metastasis beyond pelvis."@en .
obo:OBI_0002268 a obo:OBI_0002256 ;
rdfs:label "pT3b (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has macroscopic peritoneal, metastatasis beyond pelvis, 2 cm or less in greatest dimension."@en .
obo:OBI_0002269 a obo:OBI_0002256 ;
rdfs:label "pT3c (ovary)" ;
rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has peritoneal metastasis beyond pelvis, more than 2 cm in greatest dimension and/or regional lymph node metastasis."@en .
obo:OBI_0002232 a rdfs:Class ;
rdfs:label "pathologic primary tumor stage for lung according to AJCC 7th edition" ;
rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
rdfs:subClassOf obo:OBI_0001930 .
obo:OBI_0002233 a obo:OBI_0002232 ;
rdfs:label "pT0 (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .
obo:OBI_0002234 a obo:OBI_0002232 ;
rdfs:label "pTis (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating carcinoma in situ."@en .
obo:OBI_0002235 a obo:OBI_0002232 ;
rdfs:label "pT1 (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus)."@en .
obo:OBI_0002236 a obo:OBI_0002232 ;
rdfs:label "pT1a (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is 2 cm or less in greatest dimension."@en .
obo:OBI_0002237 a obo:OBI_0002232 ;
rdfs:label "pT1b (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 2 cm but not more than 3 cm in greatest dimension."@en .
obo:OBI_0002238 a obo:OBI_0002232 ;
rdfs:label "pT2 (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 3 cm but not more than 7 cm or the tumor has any of the following features: involves main bronchus, 2 cm or more distal to the carina, invades visceral pleura, associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung."@en .
obo:OBI_0002239 a obo:OBI_0002232 ;
rdfs:label "pT2a (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 3 cm but not more than 5 cm in greatest dimension."@en .
obo:OBI_0002240 a obo:OBI_0002232 ;
rdfs:label "pT2b (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 5 cm but not more than 7 cm in greatest dimension."@en .
obo:OBI_0002241 a obo:OBI_0002232 ;
rdfs:label "pT3 (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 7 cm or one that directly invades any of: parietal pleura, chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardiu or the tumor is in the main bronchus less than 2 cm distal to the carina but without involvement of the carina or there is associated atelectasis or obstructive pneumonitis of the entire lung or there is separate tumor nodule(s) in the same lobe as the primary."@en .
obo:OBI_0002242 a obo:OBI_0002232 ;
rdfs:label "pT4 (lung)" ;
rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina or there is separate tumor nodule(s) in a different ipsilateral lobe to that of the primary."@en .