PREFIX obo: <http://purl.obolibrary.org/obo/>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

obo:OVAE_0000279 a rdfs:Class ;
  rdfs:label "FluMist-associated fever AE" ;
  rdfs:comment "A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000985 .

obo:BFO_0000062 a rdf:Property ;
  rdfs:label "preceded_by" ;
  rdfs:comment "X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)" ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002086 .

obo:BFO_0000132 a rdf:Property ;
  rdfs:label "part of occurrent"@en ;
  rdfs:comment "[copied from inverse property 'has occurrent part'] b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001])" ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000015 , obo:BFO_0000011 , obo:BFO_0000008 , obo:BFO_0000003 .

obo:BFO_0000063 a rdf:Property ;
  rdfs:label "precedes" ;
  rdfs:comment "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:BFO_0000117 a rdf:Property ;
  rdfs:label "has occurrent part"@en ;
  rdfs:comment "b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001])"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 , obo:BFO_0000011 , obo:BFO_0000008 , obo:BFO_0000035 .

obo:RO_0000057 a rdf:Property ;
  rdfs:label "has participant"@en ;
  rdfs:comment "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000130 a rdf:Property ;
  rdfs:label "occupies spatiotemporal region"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000011 .

obo:BFO_0000108 a rdf:Property ;
  rdfs:label "exists at"@en ;
  rdfs:domain obo:BFO_0000001 ;
  rdfs:range obo:BFO_0000008 , obo:BFO_0000148 .

obo:BFO_0000118 a rdf:Property ;
  rdfs:label "has proper occurrent part"@en ;
  rdfs:comment "[copied from inverse property 'proper part of occurrent'] b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001])" ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:BFO_0000117 .

obo:RO_0002091 a rdf:Property ;
  rdfs:label "starts during"@en ;
  rdfs:comment "X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:BFO_0000155 a rdf:Property ;
  rdfs:label "occupies temporal region"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000008 ;
  rdfs:subPropertyOf obo:BFO_0000108 .

obo:BFO_0000139 a rdf:Property ;
  rdfs:label "temporal part of"@en ;
  rdfs:comment "b proper_temporal_part_of c =Def. b temporal_part_of c & not (b = c). (axiom label in BFO2 Reference: [116-001])"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:BFO_0000132 .

obo:BFO_0000066 a rdf:Property ;
  rdfs:label "occurs in"@en ;
  rdfs:comment "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000004 .

obo:BFO_0000169 a rdf:Property ;
  rdfs:label "specifically depends on at some time"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002222 a rdf:Property ;
  rdfs:label "temporally related to"@en ;
  rdfs:comment "A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 .

obo:VO_0000003 a rdfs:Class ;
  rdfs:label "ACAM2000" ;
  rdfs:comment "Smallpox (Vaccinia) Vaccine, Live" ;
  rdfs:subClassOf obo:VO_0000433 .

obo:BFO_0000083 a rdf:Property ;
  rdfs:label "occupies spatial region at some time"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000028 , obo:BFO_0000006 .

obo:OBI_0000312 a rdf:Property ;
  rdfs:label "is_specified_output_of"@en ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:VO_0000531 a rdf:Property ;
  rdfs:label "has vaccine allergen" ;
  rdfs:comment "a object property that specifies a relation between a vaccine and a vaccine allergen" ;
  rdfs:domain obo:VO_0000001 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000186 a rdf:Property ;
  rdfs:label "part of continuant at all times that whole exists"@en ;
  rdfs:comment "[copied from inverse property 'has continuant part at all times'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001])" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000040 , obo:BFO_0000002 , obo:BFO_0000006 ;
  rdfs:subPropertyOf obo:BFO_0000176 .

obo:OBI_0000295 a rdf:Property ;
  rdfs:label "is_specified_input_of"@en ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:RO_0000086 a rdf:Property ;
  rdfs:label "has quality"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:VO_0003355 a rdf:Property ;
  rdfs:label "vaccine immunization against microbe" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000178 a rdf:Property ;
  rdfs:label "has continuant part at some time"@en ;
  rdfs:comment "b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001])"@en ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 , obo:BFO_0000141 , obo:BFO_0000006 .

obo:bearer_of a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000304 a rdf:Property ;
  rdfs:label "is_manufactured_by"@en ;
  rdfs:comment "c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the \"Manufacturer Role\", and those people/and or machines were members or of directed by the organization to do this."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:VO_0000547 a rdf:Property ;
  rdfs:label "vaccinated in route" ;
  rdfs:comment "an object property that specifies a relation between a vaccine and a vaccinate route" ;
  rdfs:domain obo:VO_0000001 ;
  rdfs:range obo:VO_0000574 .

obo:VO_0001243 a rdf:Property ;
  rdfs:label "vaccine immunization for host" ;
  rdfs:domain obo:VO_0000001 ;
  rdfs:range obo:OBI_0100026 .

obo:BFO_0000176 a rdf:Property ;
  rdfs:label "part of continuant at some time"@en ;
  rdfs:comment "[copied from inverse property 'has continuant part at some time'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001])" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000040 , obo:BFO_0000002 , obo:BFO_0000006 .

obo:BFO_0000187 a rdf:Property ;
  rdfs:label "has continuant part at all times that part exists"@en ;
  rdfs:comment "forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t)" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 , obo:BFO_0000141 , obo:BFO_0000006 ;
  rdfs:subPropertyOf obo:BFO_0000178 .

obo:OVAE_0000388 a rdfs:Class ;
  rdfs:label "Hiberix-associated decreased appetite AE" ;
  rdfs:comment "A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000021 .

obo:OVAE_0000312 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated nausea AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000074 .

obo:OAE_0000375 a rdfs:Class ;
  rdfs:label "myalgia AE" ;
  rdfs:comment "a pain AE that has outcome of myalgia. Myalgia means \"muscle pain\" and is a symptom of many diseases and disorders." ;
  rdfs:subClassOf obo:OAE_0000374 .

obo:OAE_0001788 a rdf:Property ;
  rdfs:label "has participant quality"@en ;
  rdfs:comment "an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000594 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated arm motion limitation AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an arm motion limitation AE" ;
  rdfs:subClassOf obo:OAE_0001548 , obo:OVAE_0000039 .

obo:OVAE_0000028 a rdfs:Class ;
  rdfs:label "Kinrix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000104 .

obo:OVAE_0000398 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated diarrhea AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000035 .

obo:VO_0000053 a rdfs:Class ;
  rdfs:label "Neisseria meningitidis vaccine" ;
  rdfs:comment "A bacterial vaccine that prevents Neisseria meningitidis infection." ;
  rdfs:subClassOf obo:VO_0000165 .

obo:UBERON_0034707 a rdfs:Class ;
  rdfs:label "differentiating neuroepithelium" ;
  rdfs:comment "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." ;
  rdfs:subClassOf obo:UBERON_0034705 .

obo:BFO_0000050 a rdf:Property ;
  rdfs:label "part of" ;
  rdfs:comment "a core relation that holds between a part and its whole"@en ;
  rdfs:seeAlso <http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections> , <http://ontologydesignpatterns.org/wiki/Submissions:PartOf> , <http://www.obofoundry.org/ro/#OBO_REL:part_of> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002131 .

obo:RO_0002497 a rdf:Property ;
  rdfs:label "existence ends during or before" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002496 a rdf:Property ;
  rdfs:label "existence starts during or after" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000051 a rdf:Property ;
  rdfs:label "has part" ;
  rdfs:comment "a core relation that holds between a whole and its part"@en ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002507 , obo:RO_0002131 .

obo:OVAE_0000475 a rdfs:Class ;
  rdfs:label "Gardasil-associated injection-site pain AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000019 .

obo:NCBITaxon_12058 a rdfs:Class ;
  rdfs:label "Picornaviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35278 .

obo:OVAE_0000772 a rdfs:Class ;
  rdfs:label "YF-Vax-associated injection-site edema AE" ;
  rdfs:comment "A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0000368 , obo:OVAE_0000055 .

obo:NCBITaxon_138950 a rdfs:Class ;
  rdfs:label "Human enterovirus C" ;
  rdfs:subClassOf obo:NCBITaxon_12058 .

obo:VO_0000147 a rdfs:Class ;
  rdfs:label "vaccine adjuvant role" ;
  rdfs:comment "an adjuvant role that inheres in a vaccine component which is added as part of a vaccine and induces enhanced adaptive immune response to the vaccine antigen. " ;
  rdfs:subClassOf obo:VO_0000415 .

obo:BFO_0000052 a rdf:Property ;
  rdfs:label "inheres in at all times"@en ;
  rdfs:comment "b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002])"@en ;
  rdfs:domain obo:BFO_0000020 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000070 .

obo:inheres_in a rdf:Property ;
  rdfs:domain obo:BFO_0000020 ;
  rdfs:range obo:BFO_0000004 .

obo:NCBITaxon_117571 a rdfs:Class ;
  rdfs:label "Euteleostomi" ;
  rdfs:subClassOf obo:NCBITaxon_89593 .

obo:UBERON_0009551 a rdfs:Class ;
  rdfs:label "distal segment of digit" ;
  rdfs:comment "A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium)." ;
  rdfs:subClassOf obo:UBERON_0002529 .

obo:RO_0002488 a rdf:Property ;
  rdfs:label "existence starts during" ;
  rdfs:comment "Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002496 .

obo:RO_0002492 a rdf:Property ;
  rdfs:label "existence ends during" ;
  rdfs:comment "Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002497 .

obo:OVAE_0000214 a rdfs:Class ;
  rdfs:label "Agriflu-associated headache AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000060 .

obo:NCBITaxon_439488 a rdfs:Class ;
  rdfs:label "ssRNA viruses" ;
  rdfs:subClassOf obo:NCBITaxon_10239 .

obo:UBERON_0004905 a rdfs:Class ;
  rdfs:label "articulation" ;
  rdfs:comment "Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts." ;
  rdfs:subClassOf obo:UBERON_0034921 .

obo:RO_0002473 a rdf:Property ;
  rdfs:label "composed primarily of" ;
  rdfs:comment "x composed_primarily_of y iff: more than half of the mass of x is made from parts of y" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:OVAE_0000401 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated pain AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an pain AE" ;
  rdfs:subClassOf obo:OAE_0000374 , obo:OVAE_0000035 .

obo:VO_0000119 a rdfs:Class ;
  rdfs:label "Varivax" ;
  rdfs:comment "Product Name: Varicella Virus Vaccine Live" ;
  rdfs:subClassOf obo:VO_0000419 .

obo:UBERON_0002531 a rdfs:Class ;
  rdfs:label "paired fin bud" ;
  rdfs:comment "An outgrowth on the lateral trunk of the embryo that develops into a paired fin. The fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." ;
  rdfs:subClassOf obo:UBERON_0004357 .

obo:RO_0002220 a rdf:Property ;
  rdfs:label "adjacent_to" ;
  rdfs:comment "x adjacent_to y iff: x and y share a boundary" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002254 a rdf:Property ;
  rdfs:label "has developmental contribution from" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002507 .

obo:RO_0002387 a rdf:Property ;
  rdfs:label "has potential to develop into" ;
  rdfs:comment "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:VO_0000644 a rdfs:Class ;
  rdfs:label "Hepatitis B virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Hepatitis B virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:OVAE_0000704 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated pain AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an pain AE" ;
  rdfs:subClassOf obo:OAE_0000374 , obo:OVAE_0000047 .

obo:VO_0000300 a rdfs:Class ;
  rdfs:label "injection site" ;
  rdfs:comment "a medical intervention site that is used for injection of a substance." ;
  rdfs:subClassOf obo:OAE_0000227 .

obo:UBERON_0034768 a rdfs:Class ;
  rdfs:label "morphological feature" ;
  rdfs:comment "A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OGG_0000000002 a rdfs:Class ;
  rdfs:label "gene"@en ;
  rdfs:comment "A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule. " ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OGG_0000000016 a rdf:Property ;
  rdfs:label "is gene of organism"@en ;
  rdfs:comment "a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method. " ;
  rdfs:domain obo:OGG_0000000002 ;
  rdfs:range obo:OBI_0100026 ;
  rdfs:subPropertyOf obo:BFO_0000176 .

obo:BFO_0000034 a rdfs:Class ;
  rdfs:label "function"@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OVAE_0000624 a rdfs:Class ;
  rdfs:label "RabAvert-associated dizziness AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an dizziness AE" ;
  rdfs:subClassOf obo:OAE_0000388 , obo:OVAE_0000041 .

obo:UBERON_0015064 a rdfs:Class ;
  rdfs:label "autopod cartilage" ;
  rdfs:comment "A autopod endochondral element that is composed primarily of a cartilage tissue." ;
  rdfs:subClassOf obo:UBERON_0010881 , obo:UBERON_0015063 .

obo:RO_0002002 a rdf:Property ;
  rdfs:label "has boundary" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002202 a rdf:Property ;
  rdfs:label "develops_from" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002507 , obo:RO_0002254 .

obo:BFO_0000017 a rdfs:Class ;
  rdfs:label "realizable entity"@en ;
  rdfs:comment "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:VO_0000028 a rdfs:Class ;
  rdfs:label "Comvax" ;
  rdfs:comment "Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant)" ;
  rdfs:subClassOf obo:VO_0000746 .

obo:UBERON_0000465 a rdfs:Class ;
  rdfs:label "material anatomical entity" ;
  rdfs:comment "Anatomical entity that has mass." ;
  rdfs:subClassOf obo:UBERON_0001062 .

obo:UBERON_0010001 a rdfs:Class ;
  rdfs:label "cell cluster organ" ;
  rdfs:comment "A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function." ;
  rdfs:subClassOf obo:UBERON_0000062 , obo:UBERON_0034922 .

obo:RO_0002219 a rdf:Property ;
  rdfs:label "surrounded_by" ;
  rdfs:comment "x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000236 a rdfs:Class ;
  rdfs:label "Fluarix-associated headache AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000010 .

obo:UBERON_0002616 a rdfs:Class ;
  rdfs:label "regional part of brain" ;
  rdfs:comment "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." ;
  rdfs:subClassOf obo:UBERON_0000073 , obo:UBERON_0000481 , obo:UBERON_0004121 .

obo:OAE_0001797 a rdfs:Class ;
  rdfs:label "psychiatric disorder AE" ;
  rdfs:comment "a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative." ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:OVAE_0000434 a rdfs:Class ;
  rdfs:label "Vaqta-associated injection-site erythema AE" ;
  rdfs:comment "A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000052 .

obo:OAE_0002081 a rdf:Property ;
  rdfs:label "adverse event occurs in"@en ;
  rdfs:comment "a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:BFO_0000066 .

obo:OVAE_0000546 a rdfs:Class ;
  rdfs:label "Menactra-associated diarrhea AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000029 .

obo:OVAE_0000581 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated decreased appetite AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000039 .

obo:OVAE_0000315 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated vomiting AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000074 .

obo:UBERON_0004140 a rdfs:Class ;
  rdfs:label "primary heart field" ;
  rdfs:comment "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005291 , obo:UBERON_0007688 .

obo:OAE_0000335 a rdfs:Class ;
  rdfs:label "nasal congestion AE" ;
  rdfs:comment "nasal congestion AE is a respiratory system AE that results in a blockage of the nasal  passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels" ;
  rdfs:subClassOf obo:OAE_0000378 .

obo:UBERON_0015833 a rdfs:Class ;
  rdfs:label "foregut epithelium" ;
  rdfs:comment "A epithelium that is part of a foregut." ;
  rdfs:subClassOf obo:UBERON_0000483 , obo:UBERON_0003929 .

obo:OVAE_0000619 a rdfs:Class ;
  rdfs:label "RabAvert-associated fever AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000041 .

obo:OVAE_0000467 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated nausea AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000042 .

obo:VO_0000983 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:OAE_0000434 a rdfs:Class ;
  rdfs:label "lung AE" ;
  rdfs:comment "a respiratory system AE which has an outcome of lung disorder" ;
  rdfs:subClassOf obo:OAE_0000378 .

obo:UBERON_0011997 a rdfs:Class ;
  rdfs:label "coelom" ;
  rdfs:comment "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:UBERON_0001474 a rdfs:Class ;
  rdfs:label "bone element" ;
  rdfs:comment "Skeletal element that is composed of bone tissue." ;
  rdfs:subClassOf obo:UBERON_0004765 .

obo:VO_0000864 a rdfs:Class ;
  rdfs:label "Canada licensed vaccine role" ;
  rdfs:comment "a licensed status that occurs in Canada." ;
  rdfs:subClassOf obo:VO_0000630 .

obo:UBERON_0002384 a rdfs:Class ;
  rdfs:label "connective tissue" ;
  rdfs:comment "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:OAE_0000398 a rdfs:Class ;
  rdfs:label "cough AE" ;
  rdfs:comment "an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear" ;
  rdfs:subClassOf obo:OAE_0000571 .

obo:OVAE_0000617 a rdfs:Class ;
  rdfs:label "RabAvert-associated asthenia AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an asthenia AE" ;
  rdfs:subClassOf obo:OAE_0000382 , obo:OVAE_0000041 .

obo:OVAE_0000262 a rdfs:Class ;
  rdfs:label "Fluzone-associated injection-site pain AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000016 .

obo:VO_0001246 a rdfs:Class ;
  rdfs:label "Menveo" ;
  rdfs:subClassOf obo:VO_0000053 .

obo:OVAE_0000647 a rdfs:Class ;
  rdfs:label "Meruvax II-associated diarrhea AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000033 .

obo:OVAE_0000017 a rdfs:Class ;
  rdfs:label "Fluzone High-Dose vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Fluzone High-dose vaccine." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:UBERON_0006267 a rdfs:Class ;
  rdfs:label "notochordal plate" ;
  rdfs:comment "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." ;
  rdfs:subClassOf obo:UBERON_0000490 , obo:UBERON_0005291 , obo:UBERON_0010371 .

obo:VO_0000669 a rdfs:Class ;
  rdfs:label "Varicella-zoster virus vaccine" ;
  rdfs:comment "a Herpesvirus vaccine that is used against Varicella-zoster virus infection." ;
  rdfs:subClassOf obo:VO_0000727 .

obo:UBERON_0002418 a rdfs:Class ;
  rdfs:label "cartilage tissue" ;
  rdfs:comment "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." ;
  rdfs:subClassOf obo:UBERON_0004755 .

obo:RO_0002433 a rdf:Property ;
  rdfs:label "contributes to morphology of" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:UBERON_0014892 a rdfs:Class ;
  rdfs:label "skeletal muscle organ" ;
  rdfs:comment "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." ;
  rdfs:subClassOf obo:UBERON_0001630 , obo:UBERON_0004120 .

obo:UBERON_0012139 a rdfs:Class ;
  rdfs:label "segment of autopod" ;
  rdfs:subClassOf obo:UBERON_0002529 .

obo:OVAE_0000337 a rdfs:Class ;
  rdfs:label "Tripedia-associated injection-site redness AE" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000049 .

obo:OGG_1000000002 a rdfs:Class ;
  rdfs:label "genome of Bacteria" ;
  rdfs:comment "The genome of an organism of Bacteria" ;
  rdfs:subClassOf obo:OGG_0000000001 .

obo:OGG_0000000014 a rdf:Property ;
  rdfs:label "is genome of organism"@en ;
  rdfs:comment "a 'part of continuant at some time' relation  that incides a genome belongs to a organism. " ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:BFO_0000176 .

obo:UBERON_0005597 a rdfs:Class ;
  rdfs:label "lung primordium" ;
  rdfs:comment "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." ;
  rdfs:subClassOf obo:UBERON_0001048 .

obo:OVAE_0000269 a rdfs:Class ;
  rdfs:label "Fluzone High-Dose-associated erythema AE" ;
  rdfs:comment "A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an erythema AE" ;
  rdfs:subClassOf obo:OAE_0000645 , obo:OVAE_0000017 .

obo:OVAE_0000756 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated injection-site erythema AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000051 .

obo:OVAE_0000006 a rdfs:Class ;
  rdfs:label "bacterial and viral combination vaccine adverse event" ;
  rdfs:comment "a vaccine adverse event that is associated with administration of a bacterial and viral combination vaccine" ;
  rdfs:subClassOf obo:OAE_0000004 .

obo:OVAE_0000696 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated injection-site warmth AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site warmth AE" ;
  rdfs:subClassOf obo:OAE_0000326 , obo:OVAE_0000047 .

obo:OVAE_0000011 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Fluarix Quadrivalent vaccine." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:OVAE_0000497 a rdfs:Class ;
  rdfs:label "JE-Vax-associated malaise AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000027 .

obo:VO_0000605 a rdfs:Class ;
  rdfs:label "Canada licensed human vaccine role"@en ;
  rdfs:comment "a Canada licensed vaccine role that indicates the vaccine is used for human" ;
  rdfs:subClassOf obo:VO_0000489 , obo:VO_0000864 .

obo:OAE_0001105 a rdfs:Class ;
  rdfs:label "irritability AE" ;
  rdfs:comment "Behavior and Neurological AE that results in the patient being easily annoyed/irritated" ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:OVAE_0000486 a rdfs:Class ;
  rdfs:label "Cervarix-associated gastrointestinal disorder AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an gastrointestinal disorder AE" ;
  rdfs:subClassOf obo:OAE_0000455 , obo:OVAE_0000064 .

obo:OVAE_0000528 a rdfs:Class ;
  rdfs:label "MenHibrix-associated irritability AE" ;
  rdfs:comment "A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000030 .

obo:OVAE_0000633 a rdfs:Class ;
  rdfs:label "Rotarix-associated vomiting AE" ;
  rdfs:comment "A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000043 .

obo:OVAE_0000265 a rdfs:Class ;
  rdfs:label "Fluzone-associated malaise AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000016 .

obo:UBERON_0004151 a rdfs:Class ;
  rdfs:label "cardiac chamber" ;
  rdfs:comment "A cardiac chamber surrounds an enclosed cavity within the heart" ;
  rdfs:subClassOf obo:UBERON_0000064 , obo:UBERON_0004120 .

obo:UBERON_0003103 a rdfs:Class ;
  rdfs:label "compound organ" ;
  rdfs:comment "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:VO_0000580 a rdfs:Class ;
  rdfs:label "vaccine adjuvant" ;
  rdfs:comment "a vaccine component that is chemical substance added to vaccine and enhance and direct immune response to protective antigen. Many of vaccine adjuvants cause a range of serious side-effects." ;
  rdfs:subClassOf obo:VO_0000179 .

obo:RO_0000087 a rdf:Property ;
  rdfs:label "has role"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:UBERON_0000476 a rdfs:Class ;
  rdfs:label "acellular anatomical structure" ;
  rdfs:comment "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0000922 a rdfs:Class ;
  rdfs:label "embryo" ;
  rdfs:comment "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/503> ;
  rdfs:subClassOf obo:UBERON_0000468 .

obo:RO_0002489 a rdf:Property ;
  rdfs:label "existence starts with" ;
  rdfs:comment "Relation between continuant and occurrent, such that c comes into existence at the start of p." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002488 .

obo:RO_0002493 a rdf:Property ;
  rdfs:label "existence ends with" ;
  rdfs:comment "Relation between continuant and occurrent, such that c ceases to exist at the end of p." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002492 .

obo:OAE_0000698 a rdfs:Class ;
  rdfs:label "vasodilatation AE" ;
  rdfs:comment "a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins." ;
  rdfs:subClassOf obo:OAE_0000493 .

obo:OAE_0000381 a rdfs:Class ;
  rdfs:label "abnormal blood pressure AE" ;
  rdfs:comment "a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries" ;
  rdfs:subClassOf obo:OAE_0000493 .

obo:OAE_0001735 a rdf:Property ;
  rdfs:label "is evidence of"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000562 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated malaise AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000031 .

obo:OAE_0001548 a rdfs:Class ;
  rdfs:label "arm motion limitation AE"@en ;
  rdfs:comment "a movement disorder AE that has an outcome of arm motion limitation" ;
  rdfs:subClassOf obo:OAE_0000581 .

obo:OVAE_0000251 a rdfs:Class ;
  rdfs:label "Flucelvax-associated malaise AE" ;
  rdfs:comment "A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000012 .

obo:OVAE_0000207 a rdfs:Class ;
  rdfs:label "Afluria-associated fever AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000984 .

obo:OVAE_0000222 a rdfs:Class ;
  rdfs:label "Flulaval-associated myalgia AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000013 .

obo:VO_0010737 a rdfs:Class ;
  rdfs:label "Recombivax HB" ;
  rdfs:comment "Trade Name: Recombivax HB" ;
  rdfs:subClassOf obo:VO_0000644 .

obo:OVAE_0000355 a rdfs:Class ;
  rdfs:label "Daptacel-associated irritability AE" ;
  rdfs:comment "A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000066 .

obo:OVAE_0000396 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated unusual high-patched crying AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an unusual high-patched crying AE" ;
  rdfs:subClassOf obo:OAE_0000216 , obo:OVAE_0000035 .

obo:OVAE_0000489 a rdfs:Class ;
  rdfs:label "Ixiaro-associated injection-site tenderness AE" ;
  rdfs:comment "A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000026 .

obo:VO_0000888 a rdfs:Class ;
  rdfs:label "phenol vaccine preservative" ;
  rdfs:subClassOf obo:VO_0000851 .

obo:UBERON_0003052 a rdfs:Class ;
  rdfs:label "midbrain-hindbrain boundary" ;
  rdfs:comment "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0007651 , obo:UBERON_0010314 .

obo:RO_0002495 a rdf:Property ;
  rdfs:label "immediate transformation of" ;
  rdfs:seeAlso <http://semanticscience.org/resource/SIO_000658> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002494 .

obo:UBERON_0010083 a rdfs:Class ;
  rdfs:label "future dermis" ;
  rdfs:comment "Mesenchyme that has the potential to develop into a dermis." ;
  rdfs:subClassOf obo:UBERON_0003104 , obo:UBERON_0004120 .

obo:UBERON_0000948 a rdfs:Class ;
  rdfs:label "heart" ;
  rdfs:comment "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005181 , obo:UBERON_0007100 , obo:UBERON_0010314 .

obo:UBERON_0000409 a rdfs:Class ;
  rdfs:label "serous gland" ;
  rdfs:comment "A gland in which the principal secretory cells are serous secreting cells." ;
  rdfs:subClassOf obo:UBERON_0002365 .

obo:RO_0003000 a rdf:Property ;
  rdfs:label "produces" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000427 a rdfs:Class ;
  rdfs:label "Havrix-associated headache AE" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000020 .

obo:OVAE_0000022 a rdfs:Class ;
  rdfs:label "Imovax Rabies vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000118 .

obo:VO_0003052 a rdfs:Class ;
  rdfs:label "percutaneous vaccination" ;
  rdfs:subClassOf obo:VO_0000002 .

obo:unfolds_in a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000570 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated injection-site erythema AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000037 .

obo:OVAE_0000366 a rdfs:Class ;
  rdfs:label "Kinrix-associated injection-site pain AE" ;
  rdfs:comment "A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000028 .

obo:UBERON_0005863 a rdfs:Class ;
  rdfs:label "cartilaginous condensation" ;
  rdfs:comment "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." ;
  rdfs:subClassOf obo:UBERON_0005856 .

obo:UBERON_0010538 a rdfs:Class ;
  rdfs:label "paired limb/fin segment" ;
  rdfs:comment "An appendage segment that is part of a limb/fin." ;
  rdfs:subClassOf obo:UBERON_0010758 .

obo:OVAE_0000229 a rdfs:Class ;
  rdfs:label "Fluarix-associated arthralgia AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000010 .

obo:VO_0000675 a rdfs:Class ;
  rdfs:label "Streptococcus pneumoniae vaccine" ;
  rdfs:comment "a Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases. " ;
  rdfs:subClassOf obo:VO_0000772 .

obo:OVAE_0000606 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated injection-site erythema AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000022 .

obo:OVAE_0000385 a rdfs:Class ;
  rdfs:label "Hiberix-associated injection-site redness AE" ;
  rdfs:comment "A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000021 .

obo:OVAE_0000326 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site edema AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0000368 , obo:OVAE_0000007 .

obo:OVAE_0000076 a rdfs:Class ;
  rdfs:label "Bacillus anthracis vaccine adverse event"@en ;
  rdfs:comment "a bacterial adverse event that is associated with administration of a Bacillus anthracis vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:OVAE_0000374 a rdfs:Class ;
  rdfs:label "Pentacel-associated inconsolable crying AE" ;
  rdfs:comment "A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an inconsolable crying AE" ;
  rdfs:subClassOf obo:OAE_0000215 , obo:OVAE_0000036 .

obo:OVAE_0000345 a rdfs:Class ;
  rdfs:label "Infanrix-associated injection-site pain AE" ;
  rdfs:comment "A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000023 .

obo:OVAE_0000359 a rdfs:Class ;
  rdfs:label "Pediarix-associated injection-site pain AE" ;
  rdfs:comment "A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000034 .

obo:OVAE_0000232 a rdfs:Class ;
  rdfs:label "Fluarix-associated injection-site redness AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000010 .

obo:UBERON_0000063 a rdfs:Class ;
  rdfs:label "organ subunit" ;
  rdfs:comment "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." ;
  rdfs:subClassOf obo:UBERON_0000064 .

obo:VO_0000415 a rdfs:Class ;
  rdfs:label "vaccine additive role" ;
  rdfs:subClassOf obo:VO_0000617 .

obo:VO_0000104 a rdfs:Class ;
  rdfs:label "TYPHIM Vi" ;
  rdfs:comment "Trade Name: TYPHIM Vi" ;
  rdfs:subClassOf obo:VO_0000671 .

obo:NCBITaxon_12086 a rdfs:Class ;
  rdfs:label "Human poliovirus 3" ;
  rdfs:subClassOf obo:NCBITaxon_138950 .

obo:UBERON_2007013 a rdfs:Class ;
  rdfs:label "preplacodal ectoderm" ;
  rdfs:comment "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." ;
  rdfs:subClassOf obo:UBERON_0005497 .

obo:NCBITaxon_727 a rdfs:Class ;
  rdfs:label "Haemophilus influenzae" ;
  rdfs:subClassOf obo:NCBITaxon_724 .

obo:UBERON_0000916 a rdfs:Class ;
  rdfs:label "abdomen" ;
  rdfs:comment "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." ;
  rdfs:subClassOf obo:UBERON_0009569 .

obo:OVAE_0000644 a rdfs:Class ;
  rdfs:label "Meruvax II-associated malaise AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000033 .

obo:OVAE_0000539 a rdfs:Class ;
  rdfs:label "Menactra-associated vomiting AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000029 .

obo:VO_0000343 a rdfs:Class ;
  rdfs:label "intranasal route by spray" ;
  rdfs:subClassOf obo:VO_0000341 .

obo:RO_0001025 a rdf:Property ;
  rdfs:label "located_in" ;
  rdfs:comment "a relation between two independent continuants, the target and the location, in which the target is entirely within the location"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000598 a rdfs:Class ;
  rdfs:label "IPOL-associated injection-site induration AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000025 .

obo:OVAE_0000377 a rdfs:Class ;
  rdfs:label "Pentacel-associated injection-site edema AE" ;
  rdfs:comment "A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0001553 , obo:OVAE_0000036 .

obo:OVAE_0000584 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated fever AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000039 .

obo:OVAE_0000658 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated injection-site erythema AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000046 .

obo:UBERON_0000020 a rdfs:Class ;
  rdfs:label "sense organ" ;
  rdfs:comment "An organ that is capable of transducing sensory stimulus to the nervous system." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OVAE_0000218 a rdfs:Class ;
  rdfs:label "Flulaval-associated injection-site redness AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000013 .

obo:OVAE_0000295 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated irritability AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000011 .

obo:NCBITaxon_487 a rdfs:Class ;
  rdfs:label "Neisseria meningitidis" ;
  rdfs:subClassOf obo:NCBITaxon_28216 .

obo:OVAE_0000573 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated fatigue AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000037 .

obo:VO_0000490 a rdfs:Class ;
  rdfs:label "immunization" ;
  rdfs:comment "immunization is a processual entity that primes or modifies an adaptivie immune response to some antigens." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:PATO_0000169 a rdfs:Class ;
  rdfs:label "viability"@en ;
  rdfs:comment "An organismal quality inhering in a bearer or a population by virtue of the bearer's ability or inability to survive and develop normally or the number of surviving individuals in a given population."@en ;
  rdfs:subClassOf obo:PATO_0001237 .

obo:UBERON_0000055 a rdfs:Class ;
  rdfs:label "vessel" ;
  rdfs:comment "A tubular structure that contains, conveys body fluid, such as blood or lymph." ;
  rdfs:subClassOf obo:UBERON_0004111 .

<http://purl.obolibrary.org/obo/uberon/core#conduit_for> a rdf:Property ;
  rdfs:label "conduit for" ;
  rdfs:comment "x is a conduit for y iff y passes through the lumen of x." ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/uberon/core#channel_for> a rdf:Property ;
  rdfs:label "channel for" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OAE_0000324 a rdfs:Class ;
  rdfs:label "injection-site pruritus AE" ;
  rdfs:comment "injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection" ;
  rdfs:subClassOf obo:OAE_0000373 .

obo:UBERON_0002100 a rdfs:Class ;
  rdfs:label "trunk" ;
  rdfs:comment "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." ;
  rdfs:subClassOf obo:UBERON_0011676 .

obo:OAE_0001556 a rdfs:Class ;
  rdfs:label "fussiness AE"@en ;
  rdfs:comment "a sensory capability AE that results in a sensation of fussiness" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:OVAE_0000671 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated arthralgia AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000046 .

obo:UBERON_0004755 a rdfs:Class ;
  rdfs:label "skeletal tissue" ;
  rdfs:comment "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]" ;
  rdfs:subClassOf obo:UBERON_0002384 .

obo:OAE_0000419 a rdfs:Class ;
  rdfs:label "skin nodule AE" ;
  rdfs:comment "a skin adverse event that has an outcome of skin nodule" ;
  rdfs:subClassOf obo:OAE_0000543 .

obo:OAE_0000554 a rdfs:Class ;
  rdfs:label "abnormal digestion AE" ;
  rdfs:comment "a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy" ;
  rdfs:subClassOf obo:OAE_0000439 .

obo:UBERON_0001890 a rdfs:Class ;
  rdfs:label "forebrain" ;
  rdfs:comment "The most anterior region the brain including both the telencephalon and diencephalon." ;
  rdfs:subClassOf obo:UBERON_0002616 .

obo:OVAE_0000759 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated myalgia AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000051 .

obo:NCBITaxon_314146 a rdfs:Class ;
  rdfs:label "Euarchontoglires" ;
  rdfs:subClassOf obo:NCBITaxon_9347 .

obo:UBERON_0011584 a rdfs:Class ;
  rdfs:label "zeugopodial skeleton" ;
  rdfs:comment "Section of the forelimb skeleton located between the stylopodium and the autopodium." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

<http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to> a rdf:Property ;
  rdfs:label "proximally connected to" ;
  rdfs:comment "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BSPO_0000097 , obo:RO_0002170 , <http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to> .

obo:RO_0002576 a rdf:Property ;
  rdfs:label "skeleton of" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:VO_0000420 a rdfs:Class ;
  rdfs:label "pathogen organism component in vaccine" ;
  rdfs:comment "a vaccine component that originates from an organism such as a pathogen or a modified organism." ;
  rdfs:subClassOf obo:VO_0000179 .

obo:OVAE_0000319 a rdfs:Class ;
  rdfs:label "Biothrax-associated injection-site edema AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0000368 , obo:OVAE_0000061 .

obo:OVAE_0000629 a rdfs:Class ;
  rdfs:label "Rotarix-associated cough" ;
  rdfs:comment "A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an cough" ;
  rdfs:subClassOf obo:OAE_0000398 , obo:OVAE_0000043 .

obo:OVAE_0000471 a rdfs:Class ;
  rdfs:label "Gardasil-associated headache AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000019 .

obo:UBERON_0004062 a rdfs:Class ;
  rdfs:label "neural tube marginal layer" ;
  rdfs:comment "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter" ;
  rdfs:subClassOf obo:UBERON_0005162 .

obo:OVAE_0000655 a rdfs:Class ;
  rdfs:label "ACAM2000-associated headache AE" ;
  rdfs:comment "A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000987 .

obo:UBERON_0001009 a rdfs:Class ;
  rdfs:label "circulatory system" ;
  rdfs:comment "organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:VO_0000609 a rdfs:Class ;
  rdfs:label "viral vaccine" ;
  rdfs:comment "A vaccine that targets against a viral disease." ;
  rdfs:subClassOf obo:VO_0000001 .

obo:UBERON_0010700 a rdfs:Class ;
  rdfs:label "phalanx pre-cartilage condensation" ;
  rdfs:subClassOf obo:UBERON_0010882 , obo:UBERON_0015023 .

obo:OVAE_0000682 a rdfs:Class ;
  rdfs:label "Decavac-associated tiredness AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an tiredness AE" ;
  rdfs:subClassOf obo:OAE_0001560 , obo:OVAE_0000067 .

obo:OGG_2000001224 a rdfs:Class ;
  rdfs:label "gene of Proteobacteria" ;
  rdfs:comment "A gene of an organism of Proteobacteria" ;
  rdfs:subClassOf obo:OGG_2000000002 .

obo:BFO_0000006 a rdfs:Class ;
  rdfs:label "spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:BFO_0000123 a rdf:Property ;
  rdfs:label "has spatial occupant at some time"@en ;
  rdfs:domain obo:BFO_0000006 ;
  rdfs:range obo:BFO_0000004 .

obo:BFO_0000152 a rdf:Property ;
  rdfs:label "spatial projection of spatiotemporal at some time"@en ;
  rdfs:domain obo:BFO_0000006 ;
  rdfs:range obo:BFO_0000011 .

obo:UBERON_0004356 a rdfs:Class ;
  rdfs:label "apical ectodermal ridge" ;
  rdfs:comment "multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." ;
  rdfs:subClassOf obo:UBERON_0002050 .

obo:RO_0002256 a rdf:Property ;
  rdfs:label "developmentally_induced_by" ;
  rdfs:comment "t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000203 a rdfs:Class ;
  rdfs:label "Afluria-associated local swelling AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000984 .

obo:UBERON_0004732 a rdfs:Class ;
  rdfs:label "segmental subdivision of nervous system" ;
  rdfs:comment "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." ;
  rdfs:subClassOf obo:UBERON_0000063 .

obo:VO_0000532 a rdfs:Class ;
  rdfs:label "subcutaneous route" ;
  rdfs:comment "a route of administration that is loacted in the hypodermis (subcutaneous tissue) region. " ;
  rdfs:subClassOf obo:VO_0000574 .

obo:OVAE_0000309 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated pharyngolaryngeal pain AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an pharyngolaryngeal pain AE" ;
  rdfs:subClassOf obo:OAE_0000344 , obo:OVAE_0000074 .

obo:PATO_0001018 a rdfs:Class ;
  rdfs:label "physical quality"@en ;
  rdfs:comment "A quality of a single physical entity that exists through action of continuants at the physical level of organisation."@en ;
  rdfs:subClassOf obo:PATO_0001237 .

obo:OVAE_0000030 a rdfs:Class ;
  rdfs:label "MenHibrix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:UBERON_0000110 a rdfs:Class ;
  rdfs:label "neurula stage" ;
  rdfs:comment "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/343> ;
  rdfs:subClassOf obo:UBERON_0000067 .

obo:UBERON_0003056 a rdfs:Class ;
  rdfs:label "pre-chordal neural plate" ;
  rdfs:comment "The portion of neural plate anterior to the mid-hindbrain junction." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0005291 .

obo:BSPO_0000096 a rdf:Property ;
  rdfs:label "anterior_to" ;
  rdfs:comment "x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000273 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated local swelling AE" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000018 .

obo:UBERON_0007376 a rdfs:Class ;
  rdfs:label "outer epithelium" ;
  rdfs:comment "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]." ;
  rdfs:subClassOf obo:UBERON_0000483 , obo:UBERON_0003102 , obo:UBERON_0010371 .

obo:RO_0002007 a rdf:Property ;
  rdfs:label "bounding layer of" ;
  rdfs:comment "A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:UBERON_0011899 a rdfs:Class ;
  rdfs:label "epimysium" ;
  rdfs:comment "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0011822 .

obo:RO_0002150 a rdf:Property ;
  rdfs:label "continuous_with" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000701 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated rash AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000047 .

obo:OVAE_0000482 a rdfs:Class ;
  rdfs:label "Cervarix-associated local swelling AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000064 .

obo:OVAE_0000254 a rdfs:Class ;
  rdfs:label "Fluzone-associated injection-site tenderness AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000016 .

obo:OVAE_0000118 a rdfs:Class ;
  rdfs:label "Rabies vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Rabies vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:UBERON_0001630 a rdfs:Class ;
  rdfs:label "muscle organ" ;
  rdfs:comment "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." ;
  rdfs:subClassOf obo:UBERON_0000062 , obo:UBERON_0005090 .

obo:VO_0001015 a rdfs:Class ;
  rdfs:label "viral vaccine organism live attenuated"@en ;
  rdfs:comment "a live attenuated quality of a virus vaccine strain. " ;
  rdfs:subClassOf obo:VO_0000173 .

obo:UBERON_0003886 a rdfs:Class ;
  rdfs:label "future coelemic cavity lumen" ;
  rdfs:comment "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." ;
  rdfs:subClassOf obo:UBERON_0000464 .

obo:UBERON_0000178 a rdfs:Class ;
  rdfs:label "blood" ;
  rdfs:comment "A fluid that is composed of blood plasma and erythrocytes." ;
  rdfs:subClassOf obo:UBERON_0000179 .

obo:UBERON_0001048 a rdfs:Class ;
  rdfs:label "primordium" ;
  rdfs:comment "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:UBERON_0000026 a rdfs:Class ;
  rdfs:label "appendage" ;
  rdfs:comment "Major subdivision of an organism that protrudes from the body[DOS, CARO]." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:UBERON_0003714 a rdfs:Class ;
  rdfs:label "neural tissue" ;
  rdfs:comment "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:UBERON_0010740 a rdfs:Class ;
  rdfs:label "bone of appendage girdle complex" ;
  rdfs:comment "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." ;
  rdfs:subClassOf obo:UBERON_0001474 .

obo:OVAE_0000412 a rdfs:Class ;
  rdfs:label "Comvax-associated anorexia AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an anorexia AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000065 .

obo:UBERON_0000043 a rdfs:Class ;
  rdfs:label "tendon" ;
  rdfs:comment "Dense regular connective tissue that connects muscle to bone[VSAO]." ;
  rdfs:subClassOf obo:UBERON_0007846 .

obo:RO_0002176 a rdf:Property ;
  rdfs:label "connects" ;
  rdfs:comment "Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:UBERON_0011139 a rdfs:Class ;
  rdfs:label "synovial limb joint" ;
  rdfs:comment "Any synovial joint that is part of a (free) limb." ;
  rdfs:subClassOf obo:UBERON_0002217 , obo:UBERON_0003657 .

obo:OBI_0000047 a rdfs:Class ;
  rdfs:label "processed material"@en ;
  rdfs:comment "Is a material entity that is created or changed during material processing."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OAE_0000364 a rdfs:Class ;
  rdfs:label "syndrome AE" ;
  rdfs:comment "An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:UBERON_0011134 a rdfs:Class ;
  rdfs:label "nonsynovial joint" ;
  rdfs:comment "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." ;
  rdfs:subClassOf obo:UBERON_0000982 .

obo:OAE_0000779 a rdfs:Class ;
  rdfs:label "cardiac failure AE" ;
  rdfs:comment "a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body" ;
  rdfs:subClassOf obo:OAE_0000084 .

obo:OVAE_0000517 a rdfs:Class ;
  rdfs:label "Menveo-associated sleepiness AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an sleepiness AE" ;
  rdfs:subClassOf obo:OAE_0001550 , obo:OVAE_0000032 .

obo:UBERON_0016879 a rdfs:Class ;
  rdfs:label "future central nervous system" ;
  rdfs:comment "Primordium that develops into the central nervous system" ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:VO_0000650 a rdfs:Class ;
  rdfs:label "Rabies virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Rabies virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:OVAE_0000334 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated hypotension AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an hypotension AE" ;
  rdfs:subClassOf obo:OAE_0000551 , obo:OVAE_0000007 .

obo:NCBITaxon_1224 a rdfs:Class ;
  rdfs:label "Proteobacteria" ;
  rdfs:subClassOf obo:NCBITaxon_2 .

obo:NCBITaxon_10335 a rdfs:Class ;
  rdfs:label "Human herpesvirus 3" ;
  rdfs:subClassOf obo:NCBITaxon_10319 .

obo:OVAE_0000693 a rdfs:Class ;
  rdfs:label "Tenivac-associated muscular weakness AE" ;
  rdfs:comment "A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an muscular weakness AE" ;
  rdfs:subClassOf obo:OAE_0000333 , obo:OVAE_0000045 .

obo:OAE_0000603 a rdfs:Class ;
  rdfs:label "abnormal defecation AE" ;
  rdfs:comment "a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces"@en ;
  rdfs:subClassOf obo:OAE_0000439 .

obo:VO_0000029 a rdfs:Class ;
  rdfs:label "Daptacel" ;
  rdfs:comment "Trade Name: DAPTACEL" ;
  rdfs:subClassOf obo:VO_0000738 .

obo:OVAE_0000106 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:VO_0000639 a rdfs:Class ;
  rdfs:label "Clostridium vaccine" ;
  rdfs:comment "A bacterial vaccine that protects against infection with Clostridium spp." ;
  rdfs:subClassOf obo:VO_0000165 .

obo:OVAE_0000449 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated fever AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000042 .

obo:OVAE_0000499 a rdfs:Class ;
  rdfs:label "JE-Vax-associated chills AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an chills AE" ;
  rdfs:subClassOf obo:OAE_0000394 , obo:OVAE_0000027 .

obo:OAE_0001750 a rdfs:Class ;
  rdfs:label "severity of adverse event"@en ;
  rdfs:comment "a process quality that represents the level of severity of an adverse event." ;
  rdfs:subClassOf obo:PATO_0001236 .

obo:UBERON_0000004 a rdfs:Class ;
  rdfs:label "nose" ;
  rdfs:comment "The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity." ;
  rdfs:subClassOf obo:UBERON_0002268 , obo:UBERON_0004121 .

obo:OAE_0001553 a rdfs:Class ;
  rdfs:label "injection-site arm edema AE"@en ;
  rdfs:subClassOf obo:OAE_0000368 .

obo:UBERON_0014903 a rdfs:Class ;
  rdfs:label "primordial vasculature" ;
  rdfs:comment "A portion of tissue that will develop into vasculature." ;
  rdfs:subClassOf obo:UBERON_0001048 .

obo:UBERON_0002365 a rdfs:Class ;
  rdfs:label "exocrine gland" ;
  rdfs:comment "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:OVAE_0000715 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated malaise AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000048 .

obo:BFO_0000029 a rdfs:Class ;
  rdfs:label "site"@en ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:UBERON_0015023 a rdfs:Class ;
  rdfs:label "phalanx endochondral element" ;
  rdfs:comment "A phalanx bone or its cartilage or pre-cartilage precursor." ;
  rdfs:subClassOf obo:UBERON_0015063 .

obo:OVAE_0000630 a rdfs:Class ;
  rdfs:label "Rotarix-associated runny nose" ;
  rdfs:comment "A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an runny nose" ;
  rdfs:subClassOf obo:OAE_0000350 , obo:OVAE_0000043 .

obo:UBERON_0001714 a rdfs:Class ;
  rdfs:label "cranial ganglion" ;
  rdfs:comment "the groups of nerve cell bodies associated with the twelve cranial nerves" ;
  rdfs:subClassOf obo:UBERON_0000045 .

<http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into> a rdf:Property ;
  rdfs:label "extends_fibers_into" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002170 .

obo:OVAE_0000535 a rdfs:Class ;
  rdfs:label "Menactra-associated irritability AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000029 .

obo:UBERON_0004535 a rdfs:Class ;
  rdfs:label "cardiovascular system" ;
  rdfs:comment "Anatomical system that has as its parts the heart and blood vessels." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OVAE_0000461 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated injection-site warmth AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site warmth AE" ;
  rdfs:subClassOf obo:OAE_0000326 , obo:OVAE_0000042 .

obo:VO_0001274 a rdfs:Class ;
  rdfs:label "vaccine host role" ;
  rdfs:comment "a role of host that contains vaccine. It is a role that inheres in an organism that is the target of a vaccine administration (vaccination process)." ;
  rdfs:subClassOf obo:OBI_0000725 .

obo:BFO_0000054 a rdf:Property ;
  rdfs:label "realized in"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000987 a rdfs:Class ;
  rdfs:label "ACAM2000 vaccine adverse event" ;
  rdfs:comment "A smallpox vaccine adverse event that is associated with the administration of ACAM2000." ;
  rdfs:subClassOf obo:OVAE_0000117 .

obo:OAE_0000630 a rdfs:Class ;
  rdfs:label "ecchymosis AE" ;
  rdfs:comment "a hemorrhage AE that has an outcome of ecchymosis" ;
  rdfs:subClassOf obo:OAE_0000427 .

obo:OVAE_0000240 a rdfs:Class ;
  rdfs:label "Flublok-associated fatigue AE" ;
  rdfs:comment "A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000009 .

obo:OVAE_0000675 a rdfs:Class ;
  rdfs:label "Decavac-associated injection-site pain AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000067 .

obo:OVAE_0000044 a rdfs:Class ;
  rdfs:label "RotaTeq vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000119 .

obo:OVAE_0000301 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated gastrointestinal disorder AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an gastrointestinal disorder AE" ;
  rdfs:subClassOf obo:OAE_0000455 , obo:OVAE_0000011 .

obo:UBERON_0000982 a rdfs:Class ;
  rdfs:label "skeletal joint" ;
  rdfs:comment "Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." ;
  rdfs:subClassOf obo:UBERON_0004905 .

obo:OVAE_0000611 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated abdominal pain AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an abdominal pain AE" ;
  rdfs:subClassOf obo:OAE_0000402 , obo:OVAE_0000022 .

obo:NCBITaxon_10508 a rdfs:Class ;
  rdfs:label "Adenoviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35237 .

obo:UBERON_0006965 a rdfs:Class ;
  rdfs:label "vascular cord" ;
  rdfs:comment "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:OVAE_0000760 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated nausea AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000051 .

obo:UBERON_0005944 a rdfs:Class ;
  rdfs:label "axial skeleton plus cranial skeleton" ;
  rdfs:comment "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton> ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010912 .

obo:UBERON_0000010 a rdfs:Class ;
  rdfs:label "peripheral nervous system" ;
  rdfs:comment "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." ;
  rdfs:subClassOf obo:UBERON_0011216 .

obo:UBERON_0000926 a rdfs:Class ;
  rdfs:label "mesoderm" ;
  rdfs:comment "The middle germ layer of the embryo, between the endoderm and ectoderm." ;
  rdfs:subClassOf obo:UBERON_0000923 .

obo:VO_0003019 a rdfs:Class ;
  rdfs:label "intradermal vaccination" ;
  rdfs:subClassOf obo:VO_0000002 .

obo:OVAE_0000599 a rdfs:Class ;
  rdfs:label "IPOL-associated injection-site pain AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000025 .

obo:UBERON_0010758 a rdfs:Class ;
  rdfs:label "subdivision of organism along appendicular axis" ;
  rdfs:comment "A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:OVAE_0000259 a rdfs:Class ;
  rdfs:label "Fluzone-associated injection-site pain AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000016 .

obo:UBERON_0000104 a rdfs:Class ;
  rdfs:label "life cycle" ;
  rdfs:comment "An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/532> ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:RO_0002224 a rdf:Property ;
  rdfs:label "starts with" ;
  rdfs:comment "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 , obo:BFO_0000051 .

obo:RO_0002230 a rdf:Property ;
  rdfs:label "ends with" ;
  rdfs:comment "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 , obo:BFO_0000051 .

obo:UBERON_0005423 a rdfs:Class ;
  rdfs:label "developing anatomical structure" ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:NCBITaxon_59201 a rdfs:Class ;
  rdfs:label "Salmonella enterica subsp. enterica" ;
  rdfs:subClassOf obo:NCBITaxon_590 .

obo:VO_0000112 a rdfs:Class ;
  rdfs:label "Tripedia" ;
  rdfs:comment "Trade Name: Tripedia" ;
  rdfs:subClassOf obo:VO_0000738 .

obo:VO_0000671 a rdfs:Class ;
  rdfs:label "Salmonella typhi vaccine" ;
  rdfs:comment "a Salmonella vaccine against typhoid fever (or called typoid), caused by Salmonella enterica enterica, serovar Typhi. " ;
  rdfs:subClassOf obo:VO_0000768 .

obo:OVAE_0000219 a rdfs:Class ;
  rdfs:label "Flulaval-associated local swelling AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000013 .

obo:VO_0000424 a rdfs:Class ;
  rdfs:label "polyvalent pneumococcal vaccine" ;
  rdfs:comment "a pneumococcal vaccine that is formed using polyvalent polysaccharides" ;
  rdfs:subClassOf obo:VO_0000675 .

obo:OVAE_0000712 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated induration with tenderness AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an induration with tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001555 , obo:OVAE_0000048 .

obo:OAE_0000645 a rdfs:Class ;
  rdfs:label "erythema AE" ;
  rdfs:comment "Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin." ;
  rdfs:subClassOf obo:OAE_0000543 .

obo:OVAE_0000409 a rdfs:Class ;
  rdfs:label "Comvax-associated injection-site induration AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000065 .

obo:OVAE_0000380 a rdfs:Class ;
  rdfs:label "ActHIB-associated local swelling AE" ;
  rdfs:comment "A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000986 .

obo:UBERON_0007281 a rdfs:Class ;
  rdfs:label "presumptive midbrain hindbrain boundary" ;
  rdfs:comment "Embryonic structure that gives rise to the midbrain hindbrain boundary." ;
  rdfs:subClassOf obo:UBERON_0000015 , obo:UBERON_0006598 .

obo:UBERON_0013754 a rdfs:Class ;
  rdfs:label "integumentary system layer" ;
  rdfs:comment "A organ component layer that is part of a integumental system." ;
  rdfs:subClassOf obo:UBERON_0004923 .

obo:VO_0003026 a rdfs:Class ;
  rdfs:label "vaccine stabilizer role" ;
  rdfs:comment "a role inheres in vaccine component when added into vaccine's formulation, it tends to inhibit the reaction between two or more other vaccine substances in the final vaccine formulation; it also helps to protect the vaccine from adverse conditions such as the freeze-drying process or heat."@en ;
  rdfs:subClassOf obo:VO_0000415 .

obo:OVAE_0000268 a rdfs:Class ;
  rdfs:label "Fluzone High-Dose-associated myalgia AE" ;
  rdfs:comment "A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000017 .

obo:OVAE_0000540 a rdfs:Class ;
  rdfs:label "Menactra-associated fever AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000029 .

obo:UBERON_0002217 a rdfs:Class ;
  rdfs:label "synovial joint" ;
  rdfs:comment "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0000982 .

obo:OVAE_0000416 a rdfs:Class ;
  rdfs:label "Comvax-associated somnolence AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an somnolence AE" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000065 .

obo:UBERON_0016880 a rdfs:Class ;
  rdfs:label "future nervous system" ;
  rdfs:comment "Primordium that develops into the nervous system" ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OVAE_0000607 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated local swelling AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000022 .

obo:OVAE_0000112 a rdfs:Class ;
  rdfs:label "Herpesvirus vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Herpesvirus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:OAE_0000565 a rdfs:Class ;
  rdfs:label "vasculitis AE" ;
  rdfs:comment "an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel" ;
  rdfs:subClassOf obo:OAE_0000557 .

obo:UBERON_0003057 a rdfs:Class ;
  rdfs:label "chordal neural plate" ;
  rdfs:comment "The portion of neural plate posterior to the mid-hindbrain junction." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:BSPO_0000099 a rdf:Property ;
  rdfs:label "posterior_to" ;
  rdfs:comment "x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000073 a rdfs:Class ;
  rdfs:label "adenovirus vaccine adverse event"@en ;
  rdfs:comment "a virus vaccine adverse event that is associated with administration of an adenovirus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:UBERON_0002346 a rdfs:Class ;
  rdfs:label "neurectoderm" ;
  rdfs:comment "Embryonic ectoderm that gives rise to nervous tissue." ;
  rdfs:subClassOf obo:UBERON_0000923 , obo:UBERON_0004121 .

obo:VO_0000000 a rdfs:Class ;
  rdfs:label "part of pathogen organism in vaccine" ;
  rdfs:comment "'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism." ;
  rdfs:subClassOf obo:VO_0000420 .

obo:UBERON_0002417 a rdfs:Class ;
  rdfs:label "abdominal segment of trunk" ;
  rdfs:comment "The abdominal segment of the torso." ;
  rdfs:subClassOf obo:UBERON_0009569 , obo:UBERON_0011676 .

obo:UBERON_0000033 a rdfs:Class ;
  rdfs:label "head" ;
  rdfs:comment "The head is the anterior-most division of the body [GO]." ;
  rdfs:subClassOf obo:UBERON_0011676 .

obo:NCBITaxon_10407 a rdfs:Class ;
  rdfs:label "Hepatitis B virus" ;
  rdfs:subClassOf obo:NCBITaxon_35268 .

obo:OAE_0000001 a rdfs:Class ;
  rdfs:label "adverse event" ;
  rdfs:comment "a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event." ;
  rdfs:subClassOf obo:OGMS_0000061 .

obo:UBERON_0001893 a rdfs:Class ;
  rdfs:label "telencephalon" ;
  rdfs:comment "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." ;
  rdfs:subClassOf obo:UBERON_0002616 , obo:UBERON_0010314 .

obo:NCBITaxon_35325 a rdfs:Class ;
  rdfs:label "dsRNA viruses" ;
  rdfs:subClassOf obo:NCBITaxon_10239 .

obo:OAE_0000215 a rdfs:Class ;
  rdfs:label "inconsolable crying AE"@en ;
  rdfs:comment "a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient" ;
  rdfs:subClassOf obo:OAE_0000393 .

obo:UBERON_0005090 a rdfs:Class ;
  rdfs:label "muscle structure" ;
  rdfs:comment "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OVAE_0000033 a rdfs:Class ;
  rdfs:label "Meruvax II vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000120 .

obo:OVAE_0000298 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated muscle ache AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an muscle ache AE" ;
  rdfs:subClassOf obo:OAE_0000383 , obo:OVAE_0000011 .

obo:UBERON_0005181 a rdfs:Class ;
  rdfs:label "thoracic segment organ" ;
  rdfs:comment "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." ;
  rdfs:subClassOf obo:UBERON_0000062 , obo:UBERON_0005177 .

obo:OVAE_0000308 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated nasal congestion AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an nasal congestion AE" ;
  rdfs:subClassOf obo:OAE_0000335 , obo:OVAE_0000074 .

obo:OVAE_0000686 a rdfs:Class ;
  rdfs:label "Decavac-associated joint swelling AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an joint swelling AE" ;
  rdfs:subClassOf obo:OAE_0000327 , obo:OVAE_0000067 .

obo:UBERON_0003869 a rdfs:Class ;
  rdfs:label "presumptive ganglion" ;
  rdfs:comment "A presumptive structure that has the potential to develop into a ganglion." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:UBERON_0007285 a rdfs:Class ;
  rdfs:label "presumptive paraxial mesoderm" ;
  rdfs:comment "A presumptive structure that has the potential to develop into a paraxial mesoderm." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:NCBITaxon_517 a rdfs:Class ;
  rdfs:label "Bordetella" ;
  rdfs:subClassOf obo:NCBITaxon_80840 .

obo:OVAE_0000501 a rdfs:Class ;
  rdfs:label "JE-Vax-associated myalgia AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000027 .

obo:OVAE_0000456 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated injection-site tenderness AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000042 .

obo:VO_0000661 a rdfs:Class ;
  rdfs:label "Haemophilus vaccine" ;
  rdfs:comment "A bacterial vaccine that protects against infection with Haemophilus." ;
  rdfs:subClassOf obo:VO_0000165 .

obo:OVAE_0000641 a rdfs:Class ;
  rdfs:label "Meruvax II-associated syncope AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an syncope AE" ;
  rdfs:subClassOf obo:OAE_0000400 , obo:OVAE_0000033 .

obo:NCBITaxon_1301 a rdfs:Class ;
  rdfs:label "Streptococcus" ;
  rdfs:subClassOf obo:NCBITaxon_91061 .

obo:OVAE_0000297 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated fatigue AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000011 .

obo:OVAE_0000103 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Poliovirus vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Poliovirus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:VO_0000046 a rdfs:Class ;
  rdfs:label "Fluvirin" ;
  rdfs:comment "Trade Name: Fluvirin" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:UBERON_0001444 a rdfs:Class ;
  rdfs:label "subdivision of head" ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:UBERON_0003841 a rdfs:Class ;
  rdfs:label "autopod joint" ;
  rdfs:comment "A limb joint that is part of an autopod [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0000982 , obo:UBERON_0003657 .

obo:OVAE_0000737 a rdfs:Class ;
  rdfs:label "Boostrix-associated fatigue AE" ;
  rdfs:comment "A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000063 .

obo:UBERON_0002513 a rdfs:Class ;
  rdfs:label "endochondral bone" ;
  rdfs:comment "Replacement bone that forms within cartilage." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern> ;
  rdfs:subClassOf obo:UBERON_0001474 , obo:UBERON_0010363 .

obo:RO_0002285 a rdf:Property ;
  rdfs:label "developmentally_replaces" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:VO_0000735 a rdfs:Class ;
  rdfs:label "Corynebacterium diphtheriae vaccine" ;
  rdfs:comment "A bacterial vaccine that protects against infection with Corynebacterium diphtheriae that causes Diphtheria." ;
  rdfs:subClassOf obo:VO_0000165 .

<http://www.ebi.ac.uk/efo/EFO_0000828> a rdfs:Class ;
  rdfs:label "nose structure" ;
  rdfs:subClassOf obo:CARO_0001008 .

obo:UBERON_0010363 a rdfs:Class ;
  rdfs:label "endochondral element" ;
  rdfs:comment "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern> ;
  rdfs:subClassOf obo:UBERON_0004765 .

obo:OAE_0000442 a rdfs:Class ;
  rdfs:label "joint disorder AE" ;
  rdfs:comment "a musculoskeletal system AE which has an outcome of joint disorder" ;
  rdfs:subClassOf obo:OAE_0000027 .

obo:UBERON_0005911 a rdfs:Class ;
  rdfs:label "endo-epithelium" ;
  rdfs:comment "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0000483 , obo:UBERON_0004119 .

obo:OAE_0001840 a rdfs:Class ;
  rdfs:label "AE severity G5"@en ;
  rdfs:comment "a severity of AE that results in death." ;
  rdfs:subClassOf obo:OAE_0001750 .

obo:OVAE_0000568 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated local swelling AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000037 .

obo:UBERON_0000042 a rdfs:Class ;
  rdfs:label "serous membrane" ;
  rdfs:comment "multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." ;
  rdfs:subClassOf obo:UBERON_0000481 , obo:UBERON_0004120 .

obo:OAE_0000557 a rdfs:Class ;
  rdfs:label "inflammation AE" ;
  rdfs:comment "an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult."@en ;
  rdfs:subClassOf obo:OAE_0000476 .

obo:VO_0000885 a rdfs:Class ;
  rdfs:label "vaccine preservative role" ;
  rdfs:comment "a role inhers in a vaccine component that when added into a vccine formmulation, it can prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during administrating process or the manufacturing process." ;
  rdfs:subClassOf obo:VO_0000415 .

obo:UBERON_0011138 a rdfs:Class ;
  rdfs:label "post-cranial axial skeletal system" ;
  rdfs:comment "Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton> ;
  rdfs:subClassOf obo:UBERON_0000075 , obo:UBERON_0004120 .

obo:OAE_0000538 a rdfs:Class ;
  rdfs:label "sore throat AE" ;
  rdfs:comment "a respiratory system AE which has an outcome of sore throat" ;
  rdfs:subClassOf obo:OAE_0000378 .

obo:UBERON_0002553 a rdfs:Class ;
  rdfs:label "anatomical cavity" ;
  rdfs:comment "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." ;
  rdfs:subClassOf obo:UBERON_0000464 .

obo:RO_0001015 a rdf:Property ;
  rdfs:label "location_of" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:VO_0000006 a rdfs:Class ;
  rdfs:label "Afluria" ;
  rdfs:comment "Trade Name: Afluria" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:VO_0000908 a rdf:Property ;
  rdfs:label "is_distributed_by" ;
  rdfs:comment "is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:VO_0000270 a rdf:Property ;
  rdfs:label "has vaccine contraindication" ;
  rdfs:comment "has_vaccine_contraindication is a relation that specifies contraindication of a vaccine." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000479 a rdfs:Class ;
  rdfs:label "Gardasil-associated hematoma, bruise, ecchymoses AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an hematoma, bruise, ecchymoses AE" ;
  rdfs:subClassOf obo:OAE_0000650 , obo:OVAE_0000019 .

obo:OVAE_0000120 a rdfs:Class ;
  rdfs:label "Rubella vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Rubella vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:UBERON_0002546 a rdfs:Class ;
  rdfs:label "cranial placode" ;
  rdfs:comment "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." ;
  rdfs:subClassOf obo:UBERON_0005085 .

obo:OVAE_0000363 a rdfs:Class ;
  rdfs:label "Pediarix-associated drowsiness" ;
  rdfs:comment "A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000034 .

obo:OVAE_0000055 a rdfs:Class ;
  rdfs:label "YF-Vax vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000121 .

obo:OVAE_0000445 a rdfs:Class ;
  rdfs:label "Twinrix-associated fatigue AE" ;
  rdfs:comment "A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000050 .

obo:OAE_0000601 a rdfs:Class ;
  rdfs:label "vomiting AE" ;
  rdfs:comment "an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity"@en ;
  rdfs:subClassOf obo:OAE_0000554 .

obo:OVAE_0000669 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated musculoskeletal stiffness AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an musculoskeletal stiffness AE" ;
  rdfs:subClassOf obo:OAE_0000334 , obo:OVAE_0000046 .

obo:OVAE_0000663 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated pyrexia AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an pyrexia AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000046 .

obo:OVAE_0000719 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated nausea AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000048 .

obo:NCBITaxon_102793 a rdfs:Class ;
  rdfs:label "H5N1 subtype" ;
  rdfs:subClassOf obo:NCBITaxon_11320 .

obo:NCBITaxon_11159 a rdfs:Class ;
  rdfs:label "Paramyxovirinae" ;
  rdfs:subClassOf obo:NCBITaxon_11158 .

obo:UBERON_0000468 a rdfs:Class ;
  rdfs:label "multicellular organism" ;
  rdfs:comment "Anatomical structure that is an individual member of a species and consists of more than one cell." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:OVAE_0000275 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated OAE_0000373" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an OAE_0000373" ;
  rdfs:subClassOf obo:OAE_0000373 , obo:OVAE_0000018 .

obo:UBERON_0002067 a rdfs:Class ;
  rdfs:label "dermis" ;
  rdfs:comment "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0004121 , obo:UBERON_0010314 , obo:UBERON_0013754 .

obo:BSPO_0000107 a rdf:Property ;
  rdfs:label "deep_to" ;
  rdfs:comment "Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BSPO_0000108 a rdf:Property ;
  rdfs:label "superficial_to" ;
  rdfs:comment "Near the outer surface of the organism. Thus, skin is superficial to the muscle layer." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000628 a rdfs:Class ;
  rdfs:label "Rotarix-associated irritability AE" ;
  rdfs:comment "A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000043 .

obo:VO_0000713 a rdfs:Class ;
  rdfs:label "vaccine allergen disposition" ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OVAE_0000621 a rdfs:Class ;
  rdfs:label "RabAvert-associated myalgia AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000041 .

obo:UBERON_0000015 a rdfs:Class ;
  rdfs:label "anatomical boundary" ;
  rdfs:comment "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." ;
  rdfs:subClassOf obo:UBERON_0000466 .

obo:VO_0010711 a rdfs:Class ;
  rdfs:label "Engerix-B" ;
  rdfs:comment "Product Name: Hepatitis B Vaccine (Recombinant)" ;
  rdfs:subClassOf obo:VO_0000644 .

obo:OVAE_0000235 a rdfs:Class ;
  rdfs:label "Fluarix-associated muscle ache AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an muscle ache AE" ;
  rdfs:subClassOf obo:OAE_0000383 , obo:OVAE_0000010 .

obo:VO_0000658 a rdfs:Class ;
  rdfs:label "Rotavirus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Rotavirus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:OVAE_0000405 a rdfs:Class ;
  rdfs:label "Comvax-associated injection-site pain AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000065 .

obo:OVAE_0000552 a rdfs:Class ;
  rdfs:label "Menactra-associated arthralgia AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000029 .

obo:OVAE_0000039 a rdfs:Class ;
  rdfs:label "Prevnar 13 vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000078 .

obo:UBERON_0001062 a rdfs:Class ;
  rdfs:label "anatomical entity" ;
  rdfs:comment "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OVAE_0000488 a rdfs:Class ;
  rdfs:label "Ixiaro-associated injection-site pain AE" ;
  rdfs:comment "A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000026 .

obo:OVAE_0000589 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated fatigue AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000039 .

obo:VO_0003034 a rdfs:Class ;
  rdfs:label "sugar vaccine stabilizer" ;
  rdfs:comment "a vaccine stabilizer that is specifically made by a sugar." ;
  rdfs:subClassOf obo:VO_0000853 .

obo:PATO_0001241 a rdfs:Class ;
  rdfs:label "physical object quality" ;
  rdfs:comment "A quality which inheres in a continuant." ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:OVAE_0000747 a rdfs:Class ;
  rdfs:label "Vivotif-associated nausea AE" ;
  rdfs:comment "A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000054 .

obo:OVAE_0000579 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated injection-site redness AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000039 .

obo:OVAE_0000450 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated diarrhea AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000042 .

obo:OVAE_0000248 a rdfs:Class ;
  rdfs:label "Flucelvax-associated injection-site erythema AE" ;
  rdfs:comment "A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000012 .

obo:OVAE_0000618 a rdfs:Class ;
  rdfs:label "RabAvert-associated fatigue AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000041 .

obo:UBERON_0000107 a rdfs:Class ;
  rdfs:label "cleavage stage" ;
  rdfs:comment "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." ;
  rdfs:subClassOf obo:UBERON_0000067 .

obo:RO_0002087 a rdf:Property ;
  rdfs:label "immediately_preceded_by" ;
  rdfs:comment "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)" ;
  rdfs:seeAlso <http://semanticscience.org/resource/SIO_000251> ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:BFO_0000062 .

obo:OVAE_0000438 a rdfs:Class ;
  rdfs:label "Vaqta-associated injection-site tenderness AE" ;
  rdfs:comment "A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000052 .

obo:UBERON_0004529 a rdfs:Class ;
  rdfs:label "anatomical projection" ;
  rdfs:comment "A projection or outgrowth of tissue from a larger body or organ." ;
  rdfs:subClassOf obo:UBERON_0034768 .

obo:OAE_0000382 a rdfs:Class ;
  rdfs:label "asthenia AE" ;
  rdfs:comment "a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength." ;
  rdfs:subClassOf obo:OAE_0000435 .

obo:UBERON_0011860 a rdfs:Class ;
  rdfs:label "collection of collagen fibrils" ;
  rdfs:seeAlso obo:UBERON_0007377 ;
  rdfs:subClassOf obo:UBERON_0000476 .

obo:VO_0000090 a rdfs:Class ;
  rdfs:label "Prevnar (USA)" ;
  rdfs:comment "Trade Name: Prevnar" ;
  rdfs:subClassOf obo:VO_0000424 .

obo:UBERON_0007617 a rdfs:Class ;
  rdfs:label "synovial cavity of joint" ;
  rdfs:comment "An anatomical cavity that surrounded_by a synovial joint." ;
  rdfs:subClassOf obo:UBERON_0002553 .

obo:RO_0002572 a rdf:Property ;
  rdfs:label "luminal space of" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:OAE_0000327 a rdfs:Class ;
  rdfs:label "joint swelling AE" ;
  rdfs:comment "A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint" ;
  rdfs:subClassOf obo:OAE_0000442 .

obo:OGMS_0000060 a rdfs:Class ;
  rdfs:label "bodily process" ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:UBERON_0002097 a rdfs:Class ;
  rdfs:label "skin of body" ;
  rdfs:comment "Nonparenchymatous organ that consists of the dermis and epidermis. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body. Examples: There is only one skin[FMA]. Surface structure that consists of the external membranous integument of the animal." ;
  rdfs:subClassOf obo:CARO_0001008 , obo:UBERON_0000062 , obo:UBERON_0004121 .

obo:UBERON_0004708 a rdfs:Class ;
  rdfs:label "paired limb/fin" ;
  rdfs:comment "An appendage that is part of a appendage girdle complex." ;
  rdfs:subClassOf obo:UBERON_0000026 .

obo:RO_0002551 a rdf:Property ;
  rdfs:label "has skeleton" ;
  rdfs:comment "A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002170 a rdf:Property ;
  rdfs:label "connected to" ;
  rdfs:comment "Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship." ;
  rdfs:seeAlso <http://semanticscience.org/resource/SIO_000652> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to> .

<http://purl.obolibrary.org/obo/uberon/core#evolved_from> a rdf:Property ;
  rdfs:label "evolved_from" ;
  rdfs:comment "Status: experimental" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002158 .

obo:UBERON_0002529 a rdfs:Class ;
  rdfs:label "limb segment" ;
  rdfs:comment "A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles." ;
  rdfs:subClassOf obo:UBERON_0010538 , obo:UBERON_0010758 .

obo:OVAE_0000323 a rdfs:Class ;
  rdfs:label "Biothrax-associated headache AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000061 .

obo:UBERON_0007383 a rdfs:Class ;
  rdfs:label "enveloping layer of ectoderm" ;
  rdfs:comment "Outermost layer of cells surrounding the embryo." ;
  rdfs:subClassOf obo:UBERON_0000490 , obo:UBERON_0005291 , obo:UBERON_0010371 .

obo:OVAE_0000352 a rdfs:Class ;
  rdfs:label "Daptacel-associated injection-site tenderness AE" ;
  rdfs:comment "A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000066 .

obo:OAE_0000394 a rdfs:Class ;
  rdfs:label "chills AE" ;
  rdfs:comment "a sensory capability AE that has an outcome of chills" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:VO_0000013 a rdfs:Class ;
  rdfs:label "Bacillus anthracis vaccine" ;
  rdfs:comment "A vaccine that protects against Bacillus anthrax that causes anthrax." ;
  rdfs:subClassOf obo:VO_0000165 .

obo:OVAE_0000246 a rdfs:Class ;
  rdfs:label "Flucelvax-associated myalgia AE" ;
  rdfs:comment "A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000012 .

obo:OVAE_0000600 a rdfs:Class ;
  rdfs:label "IPOL-associated fever AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000025 .

obo:OVAE_0000347 a rdfs:Class ;
  rdfs:label "Infanrix-associated local swelling AE" ;
  rdfs:comment "A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000023 .

obo:UBERON_0003089 a rdfs:Class ;
  rdfs:label "sclerotome" ;
  rdfs:comment "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005856 , obo:UBERON_0007530 .

obo:VO_0000574 a rdfs:Class ;
  rdfs:label "route of administration" ;
  rdfs:comment "a path that is located in gross anatomical part of an organism (e.g., human) and is used for administering a vaccine, a drug, fluid, poison, or other substance into the body. " ;
  rdfs:seeAlso <http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38114> , <http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66729> ;
  rdfs:subClassOf obo:BFO_0000029 .

obo:OVAE_0000726 a rdfs:Class ;
  rdfs:label "Adacel-associated injection-site erythema AE" ;
  rdfs:comment "A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000988 .

obo:UBERON_0001017 a rdfs:Class ;
  rdfs:label "central nervous system" ;
  rdfs:comment "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0011216 .

obo:UBERON_0002470 a rdfs:Class ;
  rdfs:label "autopod region" ;
  rdfs:comment "Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot" ;
  rdfs:subClassOf obo:UBERON_0002529 .

<http://purl.obolibrary.org/obo/uberon/core#distally_connected_to> a rdf:Property ;
  rdfs:label "distally connected to" ;
  rdfs:comment "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BSPO_0000100 , obo:RO_0002170 , <http://purl.obolibrary.org/obo/uberon/core#transitively_distally_connected_to> .

obo:BFO_0000141 a rdfs:Class ;
  rdfs:label "immaterial entity"@en ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:OVAE_0000505 a rdfs:Class ;
  rdfs:label "ProQuad-associated injection-site pain AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000040 .

obo:OVAE_0000477 a rdfs:Class ;
  rdfs:label "Gardasil-associated injection-site erythema AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000019 .

obo:VO_0000854 a rdfs:Class ;
  rdfs:label "vaccine residual" ;
  rdfs:comment "a vaccine component that remains from the vaccine manufacturing process." ;
  rdfs:subClassOf obo:VO_0000179 .

obo:OVAE_0000563 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated arthralgia AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000031 .

obo:UBERON_0000122 a rdfs:Class ;
  rdfs:label "neuron projection bundle" ;
  rdfs:comment "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." ;
  rdfs:subClassOf obo:UBERON_0005162 .

obo:UBERON_0003853 a rdfs:Class ;
  rdfs:label "spinal cord neural crest" ;
  rdfs:comment "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord." ;
  rdfs:subClassOf obo:UBERON_0002342 .

obo:RO_0002385 a rdf:Property ;
  rdfs:label "has potential to developmentally contribute to" ;
  rdfs:comment "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:NCBITaxon_560210 a rdfs:Class ;
  rdfs:label "Dintheria" ;
  rdfs:subClassOf obo:NCBITaxon_33213 .

obo:UBERON_0000955 a rdfs:Class ;
  rdfs:label "brain" ;
  rdfs:comment "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." ;
  rdfs:subClassOf obo:CARO_0001008 , obo:UBERON_0000062 , obo:UBERON_0004121 .

obo:BSPO_0000123 a rdf:Property ;
  rdfs:label "in_anterior_side_of" ;
  rdfs:comment "X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:OVAE_0000734 a rdfs:Class ;
  rdfs:label "Boostrix-associated local swelling AE" ;
  rdfs:comment "A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000063 .

obo:UBERON_0000118 a rdfs:Class ;
  rdfs:label "lung bud" ;
  rdfs:comment "Structure derived from foregut that becomes a lung[GO]." ;
  rdfs:subClassOf obo:UBERON_0005153 , obo:UBERON_0005911 .

obo:OAE_0000226 a rdfs:Class ;
  rdfs:label "medical intervention site AE"@en ;
  rdfs:comment "an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site)." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OVAE_0000493 a rdfs:Class ;
  rdfs:label "JE-Vax-associated injection-site redness AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000027 .

obo:NCBITaxon_10293 a rdfs:Class ;
  rdfs:label "Alphaherpesvirinae" ;
  rdfs:subClassOf obo:NCBITaxon_10292 .

obo:OVAE_0000286 a rdfs:Class ;
  rdfs:label "FluMist Quadrivalent-associated sore throat AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an sore throat AE" ;
  rdfs:subClassOf obo:OAE_0000538 , obo:OVAE_0000014 .

obo:VO_0000123 a rdfs:Class ;
  rdfs:label "Yellow fever virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Yellow fever virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:OVAE_0000524 a rdfs:Class ;
  rdfs:label "Menveo-associated nausea AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000032 .

obo:UBERON_0005068 a rdfs:Class ;
  rdfs:label "neural rod" ;
  rdfs:comment "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." ;
  rdfs:subClassOf obo:UBERON_0016879 .

obo:OVAE_0000391 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated sleepiness AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an sleepiness AE" ;
  rdfs:subClassOf obo:OAE_0001550 , obo:OVAE_0000035 .

obo:OVAE_0000557 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated injection-site pain AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000031 .

obo:OVAE_0000636 a rdfs:Class ;
  rdfs:label "RotaTeq-associated irritability AE" ;
  rdfs:comment "A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000044 .

obo:NCBITaxon_10255 a rdfs:Class ;
  rdfs:label "Variola virus" ;
  rdfs:subClassOf obo:NCBITaxon_10241 .

obo:NCBITaxon_35237 a rdfs:Class ;
  rdfs:label "dsDNA viruses, no RNA stage" ;
  rdfs:subClassOf obo:NCBITaxon_10239 .

obo:OAE_0000439 a rdfs:Class ;
  rdfs:label "digestive system AE" ;
  rdfs:comment "an AE that occurs in digestive system." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:UBERON_0007688 a rdfs:Class ;
  rdfs:label "anlage" ;
  rdfs:comment "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." ;
  rdfs:subClassOf obo:UBERON_0000479 , obo:UBERON_0005423 .

obo:OVAE_0000652 a rdfs:Class ;
  rdfs:label "ACAM2000-associated fatigue AE" ;
  rdfs:comment "A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000987 .

obo:VO_0000173 a rdfs:Class ;
  rdfs:label "vaccine organism live attenuated" ;
  rdfs:comment "a virulence of vaccine organism that shows an attenuated pheontype of the organism as the major component of a vaccine." ;
  rdfs:subClassOf obo:PATO_0002146 .

obo:OVAE_0000614 a rdfs:Class ;
  rdfs:label "RabAvert-associated injection-site erythema AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000041 .

obo:UBERON_0009877 a rdfs:Class ;
  rdfs:label "metapodium region" ;
  rdfs:comment "Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region" ;
  rdfs:subClassOf obo:UBERON_0002529 .

obo:OVAE_0000304 a rdfs:Class ;
  rdfs:label "Influenza Virus Vaccine H5N1-associated malaise AE" ;
  rdfs:comment "A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000024 .

obo:OVAE_0000066 a rdfs:Class ;
  rdfs:label "Daptacel vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000102 .

obo:OVAE_0000709 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated injection-site warmth AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site warmth AE" ;
  rdfs:subClassOf obo:OAE_0000326 , obo:OVAE_0000048 .

obo:BFO_0000011 a rdfs:Class ;
  rdfs:label "spatiotemporal region"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:BFO_0000126 a rdf:Property ;
  rdfs:label "has spatiotemporal occupant"@en ;
  rdfs:domain obo:BFO_0000011 ;
  rdfs:range obo:BFO_0000003 .

obo:BFO_0000153 a rdf:Property ;
  rdfs:label "projects onto temporal region"@en ;
  rdfs:domain obo:BFO_0000011 ;
  rdfs:range obo:BFO_0000008 ;
  rdfs:subPropertyOf obo:BFO_0000108 .

obo:BFO_0000151 a rdf:Property ;
  rdfs:label "projects onto spatial region at some time"@en ;
  rdfs:domain obo:BFO_0000011 ;
  rdfs:range obo:BFO_0000006 .

obo:OAE_0001559 a rdfs:Class ;
  rdfs:label "joint pain AE"@en ;
  rdfs:comment "a pain AE that occurs at a joint" ;
  rdfs:subClassOf obo:OAE_0000374 .

obo:UBERON_0005085 a rdfs:Class ;
  rdfs:label "ectodermal placode" ;
  rdfs:comment "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]" ;
  rdfs:subClassOf obo:UBERON_0001048 .

obo:BFO_0000040 a rdfs:Class ;
  rdfs:label "material entity"@en ;
  rdfs:comment "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:UBERON_0012140 a rdfs:Class ;
  rdfs:label "digitopodium region" ;
  rdfs:comment "A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod> ;
  rdfs:subClassOf obo:UBERON_0012139 .

obo:OVAE_0000423 a rdfs:Class ;
  rdfs:label "Comvax-associated otitis media AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an otitis media AE" ;
  rdfs:subClassOf obo:OAE_0000340 , obo:OVAE_0000065 .

obo:UBERON_0004375 a rdfs:Class ;
  rdfs:label "bone of free limb or fin" ;
  rdfs:comment "A bone that is part of an appendage [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0001474 , obo:UBERON_0004120 , obo:UBERON_0010740 .

obo:VO_0000014 a rdfs:Class ;
  rdfs:label "Biothrax" ;
  rdfs:comment "Trade Name: Biothrax" ;
  rdfs:subClassOf obo:VO_0000013 .

obo:VO_0000744 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine" ;
  rdfs:subClassOf obo:VO_0000742 .

obo:OVAE_0000603 a rdfs:Class ;
  rdfs:label "IPOL-associated fussiness AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an fussiness AE" ;
  rdfs:subClassOf obo:OAE_0001556 , obo:OVAE_0000025 .

obo:UBERON_0003068 a rdfs:Class ;
  rdfs:label "axial mesoderm" ;
  rdfs:comment "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:UBERON_0007026 a rdfs:Class ;
  rdfs:label "presumptive gut" ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OAE_0000336 a rdfs:Class ;
  rdfs:label "nasopharyngitis AE" ;
  rdfs:comment "a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system" ;
  rdfs:subClassOf obo:OAE_0000564 .

obo:NCBITaxon_11234 a rdfs:Class ;
  rdfs:label "Measles virus" ;
  rdfs:subClassOf obo:NCBITaxon_11229 .

obo:VO_0000093 a rdfs:Class ;
  rdfs:label "mineral salt vaccine adjuvant" ;
  rdfs:comment "a vaccine adjuvant that is formed as a mineral salt." ;
  rdfs:subClassOf obo:VO_0000580 .

obo:OVAE_0000758 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated headache AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000051 .

obo:OAE_0000383 a rdfs:Class ;
  rdfs:label "muscle ache AE" ;
  rdfs:comment "a muscle pain AE that has an outcome of muscle ache." ;
  rdfs:subClassOf obo:OAE_0000375 .

obo:OVAE_0000496 a rdfs:Class ;
  rdfs:label "JE-Vax-associated headache AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000027 .

obo:UBERON_0011215 a rdfs:Class ;
  rdfs:label "central nervous system cell part cluster" ;
  rdfs:comment "A multi cell part structure that is part of a central nervous system." ;
  rdfs:subClassOf obo:UBERON_0005162 .

obo:OVAE_0000318 a rdfs:Class ;
  rdfs:label "Biothrax-associated injection-site erythema AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000061 .

obo:NCBITaxon_1485 a rdfs:Class ;
  rdfs:label "Clostridium" ;
  rdfs:subClassOf obo:NCBITaxon_1239 .

obo:UBERON_0000025 a rdfs:Class ;
  rdfs:label "tube" ;
  rdfs:comment "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." ;
  rdfs:subClassOf obo:UBERON_0004111 .

obo:NCBITaxon_10319 a rdfs:Class ;
  rdfs:label "Varicellovirus" ;
  rdfs:subClassOf obo:NCBITaxon_10293 .

obo:OVAE_0000988 a rdfs:Class ;
  rdfs:label "Adacel vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000102 .

obo:OVAE_0000448 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated irritability AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000042 .

obo:OVAE_0000635 a rdfs:Class ;
  rdfs:label "RotaTeq-associated vomiting AE" ;
  rdfs:comment "A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000044 .

obo:UBERON_0010000 a rdfs:Class ;
  rdfs:label "multicellular anatomical structure" ;
  rdfs:comment "An anatomical structure that has more than one cell as a part." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0001033 a rdfs:Class ;
  rdfs:label "gustatory system" ;
  rdfs:comment "The sensory system for the sense of taste." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:UBERON_0006268 a rdfs:Class ;
  rdfs:label "notochordal process" ;
  rdfs:comment "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot" ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:OVAE_0000654 a rdfs:Class ;
  rdfs:label "ACAM2000-associated myalgia AE" ;
  rdfs:comment "A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000987 .

obo:VO_0000887 a rdfs:Class ;
  rdfs:label "intradermal route" ;
  rdfs:comment "a route of administration that inject the material(such as vaccines, allergens) into the skin itself." ;
  rdfs:subClassOf obo:VO_0000574 .

obo:OAE_0000639 a rdfs:Class ;
  rdfs:label "low-grade fever AE" ;
  rdfs:comment "low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C)." ;
  rdfs:subClassOf obo:OAE_0000361 .

obo:UBERON_0005256 a rdfs:Class ;
  rdfs:label "trunk mesenchyme" ;
  rdfs:comment "Mesenchyme that is part of a developing trunk." ;
  rdfs:subClassOf obo:UBERON_0003104 , obo:UBERON_0005291 .

obo:VO_0000065 a rdfs:Class ;
  rdfs:label "Influenza Virus Vaccine H5N1 (Sanofi Pasteur Inc)" ;
  rdfs:comment "Product Name: Influenza Virus Vaccine, H5N1 (for National Stockpile)" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:UBERON_0010316 a rdfs:Class ;
  rdfs:label "germ layer / neural crest" ;
  rdfs:subClassOf obo:UBERON_0005291 .

obo:VO_0000984 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid (for Boost use Only) by Sanofi Pasteur Inc"@en ;
  rdfs:comment "a tetanus vaccine manusfactured by Sanofi Pasteur Inc. that is only for booster use (not recommended for primary immunization)" ;
  rdfs:subClassOf obo:VO_0000640 .

obo:UBERON_0004765 a rdfs:Class ;
  rdfs:label "skeletal element" ;
  rdfs:comment "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:UBERON_0011695 a rdfs:Class ;
  rdfs:label "embryonic cardiovascular system" ;
  rdfs:comment "A cardiovascular system that is part of a conceptus." ;
  rdfs:subClassOf obo:UBERON_0004535 .

obo:UBERON_0010882 a rdfs:Class ;
  rdfs:label "limb bone pre-cartilage condensation" ;
  rdfs:comment "A skeletal element that is part of a limb and composed of pre-cartilage tissue." ;
  rdfs:subClassOf obo:UBERON_0015061 .

obo:OAE_0000027 a rdfs:Class ;
  rdfs:label "musculoskeletal or connective tissue AE" ;
  rdfs:comment "an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OVAE_0000459 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated ecchymosis AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an ecchymosis AE" ;
  rdfs:subClassOf obo:OAE_0000630 , obo:OVAE_0000042 .

obo:UBERON_0002028 a rdfs:Class ;
  rdfs:label "hindbrain" ;
  rdfs:comment "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." ;
  rdfs:subClassOf obo:UBERON_0002616 , obo:UBERON_0010314 .

obo:OVAE_0000597 a rdfs:Class ;
  rdfs:label "IPOL-associated injection-site erythema AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000025 .

obo:OVAE_0000660 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated injection-site pruritus AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site pruritus AE" ;
  rdfs:subClassOf obo:OAE_0000324 , obo:OVAE_0000046 .

obo:BFO_0000005 a rdfs:Class ;
  rdfs:label "dependent continuant"@en ;
  rdfs:comment "A continuant  that is either dependent on one or other independent continuant  bearers or inheres in or is borne by other entities."@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:OVAE_0000625 a rdfs:Class ;
  rdfs:label "RabAvert-associated lymphadenopathy AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an lymphadenopathy AE" ;
  rdfs:subClassOf obo:OAE_0000331 , obo:OVAE_0000041 .

obo:OVAE_0000538 a rdfs:Class ;
  rdfs:label "Menactra-associated decreased appetite AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000029 .

obo:VO_0000054 a rdfs:Class ;
  rdfs:label "IPOL" ;
  rdfs:comment "Trade Name: IPOL" ;
  rdfs:subClassOf obo:VO_0000664 .

obo:OVAE_0000261 a rdfs:Class ;
  rdfs:label "Fluzone-associated myalgia AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000016 .

obo:UBERON_0004357 a rdfs:Class ;
  rdfs:label "paired limb/fin bud" ;
  rdfs:comment "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." ;
  rdfs:subClassOf obo:UBERON_0002050 , obo:UBERON_0003102 , obo:UBERON_0006598 .

obo:UBERON_0009142 a rdfs:Class ;
  rdfs:label "entire embryonic mesenchyme" ;
  rdfs:comment "Sum total of mesenchyme in the embryo." ;
  rdfs:subClassOf obo:UBERON_0000477 .

obo:VO_0000491 a rdfs:Class ;
  rdfs:label "active immunization" ;
  rdfs:comment "Active immunization is an immunization process that entails the introduction of a foreign molecule into the body, which causes the body itself to generate adaptive immunity against the target." ;
  rdfs:subClassOf obo:VO_0000490 .

obo:OVAE_0000755 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated injection-site induration AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000051 .

obo:UBERON_0000060 a rdfs:Class ;
  rdfs:label "anatomical wall" ;
  rdfs:comment "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." ;
  rdfs:subClassOf obo:UBERON_0000064 .

obo:VO_0000094 a rdfs:Class ;
  rdfs:label "RabAvert" ;
  rdfs:comment "Product Name: Rabies Vaccine" ;
  rdfs:subClassOf obo:VO_0000650 .

obo:OVAE_0000699 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated induration with tenderness AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an induration with tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001555 , obo:OVAE_0000047 .

obo:UBERON_0007010 a rdfs:Class ;
  rdfs:label "cleaving embryo" ;
  rdfs:comment "Organism at the cleavage stage." ;
  rdfs:subClassOf obo:UBERON_0000468 , obo:UBERON_0000922 .

obo:UBERON_0002330 a rdfs:Class ;
  rdfs:label "exocrine system" ;
  rdfs:comment "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OVAE_0000387 a rdfs:Class ;
  rdfs:label "Hiberix-associated fussiness AE" ;
  rdfs:comment "A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an fussiness AE" ;
  rdfs:subClassOf obo:OAE_0001556 , obo:OVAE_0000021 .

obo:VO_0001357 a rdfs:Class ;
  rdfs:label "synthetic vaccine adjuvant" ;
  rdfs:comment "A vaccine aduvant that contains synthetic material." ;
  rdfs:subClassOf obo:VO_0000580 .

obo:UBERON_0003104 a rdfs:Class ;
  rdfs:label "mesenchyme" ;
  rdfs:comment "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO]." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:UBERON_0006215 a rdfs:Class ;
  rdfs:label "rhombic lip" ;
  rdfs:comment "the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system" ;
  rdfs:subClassOf obo:UBERON_0001048 , obo:UBERON_0006598 .

obo:UBERON_0000071 a rdfs:Class ;
  rdfs:label "death stage" ;
  rdfs:comment "End of the life of an organism." ;
  rdfs:subClassOf obo:UBERON_0000105 .

obo:RO_0002229 a rdf:Property ;
  rdfs:label "ends" ;
  rdfs:comment "Relation between occurrents, shares an end boundary with." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:OVAE_0000237 a rdfs:Class ;
  rdfs:label "Fluarix-associated fatigue AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000010 .

obo:UBERON_0003849 a rdfs:Class ;
  rdfs:label "mesencephalic neural crest" ;
  rdfs:comment "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." ;
  rdfs:subClassOf obo:UBERON_0002342 , obo:UBERON_0003099 .

obo:OVAE_0000437 a rdfs:Class ;
  rdfs:label "Vaqta-associated injection-site pain AE" ;
  rdfs:comment "A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000052 .

obo:OVAE_0000395 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated injection-site induration AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000035 .

obo:UBERON_0011583 a rdfs:Class ;
  rdfs:label "stylopodial skeleton" ;
  rdfs:comment "Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

obo:OAE_0000333 a rdfs:Class ;
  rdfs:label "muscular weakness AE" ;
  rdfs:comment "a muscle AE that has an outcome of muscular weakness AE (i.e.,  lack of muscle strength)." ;
  rdfs:subClassOf obo:OAE_0000435 .

obo:UBERON_0006716 a rdfs:Class ;
  rdfs:label "mesopodium region" ;
  rdfs:comment "The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus)" ;
  rdfs:subClassOf obo:UBERON_0002529 .

obo:OVAE_0000109 a rdfs:Class ;
  rdfs:label "Hepatitis A virus vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Hepatitis A virus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:UBERON_0001558 a rdfs:Class ;
  rdfs:label "lower respiratory tract" ;
  rdfs:comment "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]" ;
  rdfs:subClassOf obo:UBERON_0000072 .

<http://purl.obolibrary.org/obo/uberon/core#subdivision_of> a rdf:Property ;
  rdfs:label "subdivision of" ;
  rdfs:comment "placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000336 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated arthralgia AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000007 .

obo:UBERON_0005856 a rdfs:Class ;
  rdfs:label "developing mesenchymal condensation" ;
  rdfs:comment "A delimited region of dense mesenchyme within looser mesenchyme." ;
  rdfs:subClassOf obo:UBERON_0007524 , obo:UBERON_0011585 .

obo:OAE_0000369 a rdfs:Class ;
  rdfs:label "injection-site pain AE" ;
  rdfs:comment "a pain AE that occurs in an injection site of a medical intervention" ;
  rdfs:subClassOf obo:OAE_0000374 .

obo:UBERON_0010286 a rdfs:Class ;
  rdfs:label "midbrain neural tube" ;
  rdfs:comment "Portion of neural tube that gives rise to the midbrain." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0005291 .

obo:OVAE_0000018 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Fluzone intradermal vaccine." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:OAE_0000376 a rdfs:Class ;
  rdfs:label "urticaria AE" ;
  rdfs:comment "Urticaria AE is a rash AE notable for dark red, raised, itchy bumps." ;
  rdfs:subClassOf obo:OAE_0000362 .

obo:UBERON_0001484 a rdfs:Class ;
  rdfs:label "articular capsule" ;
  rdfs:comment "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]." ;
  rdfs:subClassOf obo:UBERON_0000094 .

obo:RO_0002221 a rdf:Property ;
  rdfs:label "surrounds" ;
  rdfs:comment "inverse of surrounded_by" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000331 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated malaise AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000007 .

obo:OVAE_0000051 a rdfs:Class ;
  rdfs:label "Typhim Vi vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000107 .

obo:OVAE_0000571 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated headache AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000037 .

obo:OAE_0001147 a rdfs:Class ;
  rdfs:label "lymphadenopathy AE" ;
  rdfs:comment "an immune system disorder AE that has an outcome of lymphadenopathy, which is a term meaning \"disease of the lymph nodes\" . It is generally a disease or inflammation of the lymph nodes, could be due to infection, auto-immune disease or malignancy" ;
  rdfs:subClassOf obo:OAE_0000476 .

obo:UBERON_0002471 a rdfs:Class ;
  rdfs:label "zeugopod" ;
  rdfs:comment "The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus)." ;
  rdfs:subClassOf obo:UBERON_0002529 .

obo:BSPO_0000097 a rdf:Property ;
  rdfs:label "distal_to" ;
  rdfs:comment "x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal)." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BSPO_0000100 a rdf:Property ;
  rdfs:label "proximal_to" ;
  rdfs:comment "x proximal_to y iff x is closer to the point of attachment with the body than y." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000777 a rdfs:Class ;
  rdfs:label "Zostavax-associated injection-site reaction" ;
  rdfs:comment "A Zostavax vaccine adverse event that is associated with an administration of Zostavax and displays an injection-site reaction" ;
  rdfs:subClassOf obo:OAE_0000366 , obo:OVAE_0000056 .

obo:OVAE_0000474 a rdfs:Class ;
  rdfs:label "Gardasil-associated dizziness AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an dizziness AE" ;
  rdfs:subClassOf obo:OAE_0000388 , obo:OVAE_0000019 .

obo:OVAE_0000291 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated injection-site pain AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000011 .

obo:VO_0000083 a rdfs:Class ;
  rdfs:label "PedvaxHIB" ;
  rdfs:comment "Trade Name: PedvaxHIB" ;
  rdfs:subClassOf obo:VO_0000662 .

obo:VO_0000043 a rdfs:Class ;
  rdfs:label "FluLaval" ;
  rdfs:comment "Trade Name: FluLaval" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:OAE_0000002 a rdfs:Class ;
  rdfs:label "medical intervention" ;
  rdfs:comment "medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. " ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OVAE_0000376 a rdfs:Class ;
  rdfs:label "Pentacel-associated injection-site tenderness AE" ;
  rdfs:comment "A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000036 .

obo:UBERON_0004770 a rdfs:Class ;
  rdfs:label "articular system" ;
  rdfs:comment "Anatomical system that consists of all the joints of the body." ;
  rdfs:subClassOf obo:UBERON_0034925 .

obo:RO_0002351 a rdf:Property ;
  rdfs:label "has member" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:UBERON_0010701 a rdfs:Class ;
  rdfs:label "phalanx cartilage element" ;
  rdfs:subClassOf obo:UBERON_0015023 , obo:UBERON_0015064 .

obo:VO_0000741 a rdfs:Class ;
  rdfs:label "Haemophilus influenzae serotype b" ;
  rdfs:subClassOf obo:NCBITaxon_727 .

obo:UBERON_0001003 a rdfs:Class ;
  rdfs:label "skin epidermis" ;
  rdfs:comment "The outer epithelial layer of the skin that is superficial to the dermis." ;
  rdfs:subClassOf obo:UBERON_0007376 , obo:UBERON_3000961 .

obo:UBERON_0000490 a rdfs:Class ;
  rdfs:label "unilaminar epithelium" ;
  rdfs:comment "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0000483 .

obo:UBERON_0003657 a rdfs:Class ;
  rdfs:label "limb joint" ;
  rdfs:comment "Any joint that is part of a (free) limb." ;
  rdfs:subClassOf obo:UBERON_0000982 .

obo:OVAE_0000705 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated hypotension AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an hypotension AE" ;
  rdfs:subClassOf obo:OAE_0000551 , obo:OVAE_0000047 .

obo:UBERON_0010543 a rdfs:Class ;
  rdfs:label "acropodial skeleton" ;
  rdfs:comment "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

obo:UBERON_0015228 a rdfs:Class ;
  rdfs:label "circulatory organ" ;
  rdfs:comment "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile." ;
  rdfs:subClassOf obo:UBERON_0003103 .

obo:OVAE_0000325 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site warmth AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site warmth AE" ;
  rdfs:subClassOf obo:OAE_0000326 , obo:OVAE_0000007 .

obo:BFO_0000023 a rdfs:Class ;
  rdfs:label "role"@en ;
  rdfs:comment "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts."@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:OVAE_0000062 a rdfs:Class ;
  rdfs:label "Flublok-associated muscle pain AE"@en ;
  rdfs:comment "A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a muscle pain AE" ;
  rdfs:subClassOf obo:OAE_0000383 , obo:OVAE_0000009 .

obo:OAE_0000564 a rdfs:Class ;
  rdfs:label "respiratory system inflammation AE" ;
  rdfs:comment "an inflammation AE which has an outcome of respiratory system inflammation, the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" ;
  rdfs:subClassOf obo:OAE_0000557 .

obo:UBERON_0012150 a rdfs:Class ;
  rdfs:label "skeleton of digitopodium" ;
  rdfs:comment "A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod> ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

obo:UBERON_0001049 a rdfs:Class ;
  rdfs:label "neural tube" ;
  rdfs:comment "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." ;
  rdfs:subClassOf obo:UBERON_0003914 , obo:UBERON_0005291 , obo:UBERON_0010371 , obo:UBERON_0016879 .

obo:UBERON_0004111 a rdfs:Class ;
  rdfs:label "anatomical conduit" ;
  rdfs:comment "Any tube, opening or passage that connects two distinct anatomical spaces." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:UBERON_0002105 a rdfs:Class ;
  rdfs:label "vestibulo-auditory system" ;
  rdfs:comment "Sensory system responsible for the perception of spatial orientation and auditory stimuli." ;
  rdfs:subClassOf obo:UBERON_0001032 .

obo:OVAE_0000632 a rdfs:Class ;
  rdfs:label "Rotarix-associated decreased appetite AE" ;
  rdfs:comment "A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000043 .

obo:OVAE_0000697 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated injection-site edema AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0000368 , obo:OVAE_0000047 .

obo:UBERON_0005177 a rdfs:Class ;
  rdfs:label "trunk region element" ;
  rdfs:comment "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OVAE_0000250 a rdfs:Class ;
  rdfs:label "Flucelvax-associated headache AE" ;
  rdfs:comment "A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000012 .

obo:UBERON_0010712 a rdfs:Class ;
  rdfs:label "limb skeleton subdivision" ;
  rdfs:comment "Skeletal subdivision that is a segment of the limb skeleton." ;
  rdfs:subClassOf obo:UBERON_0010912 .

obo:VO_0000079 a rdfs:Class ;
  rdfs:label "Fluzone High-dose"@en ;
  rdfs:comment "an influenza vaccine that is similar to Fluzone but has high dose. " ;
  rdfs:subClassOf obo:VO_0000642 .

obo:VO_0000913 a rdfs:Class ;
  rdfs:label "latex vaccine allergen" ;
  rdfs:subClassOf obo:VO_0000910 .

<http://www.obofoundry.org/ro/ro.owl#has_disposition> a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:UBERON_0000105 a rdfs:Class ;
  rdfs:label "life cycle stage" ;
  rdfs:comment "A spatiotemporal region encompassing some part of the life cycle of an organism." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OVAE_0000257 a rdfs:Class ;
  rdfs:label "Fluzone-associated drowsiness" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000016 .

obo:OVAE_0000773 a rdfs:Class ;
  rdfs:label "YF-Vax-associated hypersensitivity AE" ;
  rdfs:comment "A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an hypersensitivity AE" ;
  rdfs:subClassOf obo:OAE_0000584 , obo:OVAE_0000055 .

obo:UBERON_3000961 a rdfs:Class ;
  rdfs:label "external integument structure" ;
  rdfs:comment "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument." ;
  rdfs:subClassOf obo:UBERON_0003102 .

obo:OVAE_0000283 a rdfs:Class ;
  rdfs:label "FluMist Quadrivalent-associated nasal congestion AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an nasal congestion AE" ;
  rdfs:subClassOf obo:OAE_0000335 , obo:OVAE_0000014 .

obo:OVAE_0000040 a rdfs:Class ;
  rdfs:label "ProQuad vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000115 .

obo:OVAE_0000036 a rdfs:Class ;
  rdfs:label "Pentacel vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000104 .

obo:OVAE_0000384 a rdfs:Class ;
  rdfs:label "Hiberix-associated injection-site pain AE" ;
  rdfs:comment "A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000021 .

obo:BFO_0000016 a rdfs:Class ;
  rdfs:label "disposition"@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:VO_0000746 a rdfs:Class ;
  rdfs:label "Haemophilus b and Hepatitis B vaccine" ;
  rdfs:comment "a viral vaccine against Hepatitis B virus and at the same time against bacterial H. influenzae serotype b." ;
  rdfs:subClassOf obo:VO_0000644 .

obo:UBERON_0003606 a rdfs:Class ;
  rdfs:label "limb long bone" ;
  rdfs:comment "A long bone that is part of a limb [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0002428 , obo:UBERON_0002495 .

obo:OVAE_0000354 a rdfs:Class ;
  rdfs:label "Daptacel-associated injection-site edema AE" ;
  rdfs:comment "A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0001553 , obo:OVAE_0000066 .

obo:PATO_0001237 a rdfs:Class ;
  rdfs:label "quality of a single physical entity"@en ;
  rdfs:comment "A physical object quality which inheres in a single-bearer."@en ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:VO_0000640 a rdfs:Class ;
  rdfs:label "Clostridium tetani vaccine" ;
  rdfs:comment "a Clostridium vaccine that protects against infection with Clostridium tetani that causes tenanus." ;
  rdfs:subClassOf obo:VO_0000639 .

obo:OVAE_0000707 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated arthralgia AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000047 .

obo:OVAE_0000314 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated diarrhea AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000074 .

obo:OVAE_0000639 a rdfs:Class ;
  rdfs:label "RotaTeq-associated bronchospasm AE" ;
  rdfs:comment "A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an bronchospasm AE" ;
  rdfs:subClassOf obo:OAE_0000770 , obo:OVAE_0000044 .

obo:UBERON_0003082 a rdfs:Class ;
  rdfs:label "myotome" ;
  rdfs:comment "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." ;
  rdfs:subClassOf obo:UBERON_0017650 .

obo:OVAE_0000668 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated myalgia AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000046 .

obo:UBERON_0006238 a rdfs:Class ;
  rdfs:label "future brain" ;
  rdfs:comment "The embryonic precursor of the brain." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:UBERON_0006596 a rdfs:Class ;
  rdfs:label "presumptive blood" ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OVAE_0000272 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated injection-site induration AE" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000018 .

obo:VO_0000651 a rdfs:Class ;
  rdfs:label "Smallpox virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Smallpox virus." ;
  rdfs:subClassOf obo:VO_0000512 .

obo:OAE_0000344 a rdfs:Class ;
  rdfs:label "pharyngolaryngeal pain AE" ;
  rdfs:comment "a pain AE that shows a pain in sinus and throat" ;
  rdfs:subClassOf obo:OAE_0000374 .

obo:OVAE_0000560 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated headache AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000031 .

obo:NCBITaxon_90370 a rdfs:Class ;
  rdfs:label "Salmonella enterica subsp. enterica serovar Typhi" ;
  rdfs:subClassOf obo:NCBITaxon_59201 .

obo:OVAE_0000585 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated irritability AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000039 .

obo:OAE_0000399 a rdfs:Class ;
  rdfs:label "flu syndrome AE" ;
  rdfs:comment "a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention.  " ;
  rdfs:subClassOf obo:OAE_0000490 .

obo:OVAE_0000766 a rdfs:Class ;
  rdfs:label "Varivax-associated injection-site adverse event" ;
  rdfs:comment "A Varivax vaccine adverse event that is associated with an administration of Varivax and displays an injection-site adverse event" ;
  rdfs:subClassOf obo:OAE_0000366 , obo:OVAE_0000053 .

obo:UBERON_0007846 a rdfs:Class ;
  rdfs:label "dense regular connective tissue" ;
  rdfs:comment "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." ;
  rdfs:subClassOf obo:UBERON_0007845 , obo:UBERON_0011823 .

obo:UBERON_0000930 a rdfs:Class ;
  rdfs:label "stomodeum" ;
  rdfs:comment "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." ;
  rdfs:subClassOf obo:UBERON_0002050 , obo:UBERON_0013522 .

obo:UBERON_0004921 a rdfs:Class ;
  rdfs:label "subdivision of digestive tract" ;
  rdfs:comment "A proximal-distal subdivision of the digestive tract." ;
  rdfs:subClassOf obo:UBERON_0013522 .

obo:OAE_0001557 a rdfs:Class ;
  rdfs:label "decreased sleep AE"@en ;
  rdfs:comment "a sleep disorder AE that shows decreased sleep" ;
  rdfs:subClassOf obo:OAE_0001403 .

obo:OVAE_0000731 a rdfs:Class ;
  rdfs:label "Adacel-associated muscular weakness AE" ;
  rdfs:comment "A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an muscular weakness AE" ;
  rdfs:subClassOf obo:OAE_0000333 , obo:OVAE_0000988 .

obo:VO_0000968 a rdfs:Class ;
  rdfs:label "pBLUESCRIPT DNA vaccine plasmid"@en ;
  rdfs:comment "A DNA vaccine plasmid vector that has the plasmid label pBLUESCRIPT." ;
  rdfs:subClassOf obo:VO_0000435 .

obo:UBERON_0003887 a rdfs:Class ;
  rdfs:label "intraembryonic coelom" ;
  rdfs:comment "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom" ;
  rdfs:subClassOf obo:UBERON_0002050 , obo:UBERON_0004120 .

obo:OVAE_0000527 a rdfs:Class ;
  rdfs:label "MenHibrix-associated local swelling AE" ;
  rdfs:comment "A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000030 .

obo:OVAE_0000415 a rdfs:Class ;
  rdfs:label "Comvax-associated irritability AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000065 .

obo:OVAE_0000047 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid (boost only) vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000100 .

obo:UBERON_0000165 a rdfs:Class ;
  rdfs:label "mouth" ;
  rdfs:comment "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/661> ;
  rdfs:subClassOf obo:CARO_0001008 , obo:UBERON_0004921 .

obo:BSPO_0001106 a rdf:Property ;
  rdfs:label "proximalmost_part_of" ;
  rdfs:comment "X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BSPO_0000124 .

obo:OVAE_0000007 a rdfs:Class ;
  rdfs:label "adverse event associated with Diphtheria & Tetanus Toxoids Absorbed" ;
  rdfs:subClassOf obo:OVAE_0000101 .

obo:UBERON_0002495 a rdfs:Class ;
  rdfs:label "long bone" ;
  rdfs:comment "Long bone is a limb bone that is subcylindrical and has a shaft with periosteum separating the ends of the bones. Long bones are present only in the limbs[VSAO:wd]." ;
  rdfs:subClassOf obo:UBERON_0001474 .

obo:IAO_0000030 a rdfs:Class ;
  rdfs:label "information content entity"@en ;
  rdfs:comment "A generically dependent continuant that is about some thing."@en ;
  rdfs:subClassOf obo:BFO_0000031 .

obo:BFO_0000058 a rdf:Property ;
  rdfs:label "concretized by at some time"@en ;
  rdfs:domain obo:BFO_0000031 ;
  rdfs:range obo:BFO_0000020 .

obo:OAE_0000546 a rdfs:Class ;
  rdfs:label "abnormal fluid regulation AE" ;
  rdfs:comment "a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid" ;
  rdfs:subClassOf obo:OAE_0000555 .

obo:UBERON_0004288 a rdfs:Class ;
  rdfs:label "skeleton" ;
  rdfs:comment "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/The-skeletal-system> ;
  rdfs:subClassOf obo:UBERON_0034925 .

obo:OVAE_0000677 a rdfs:Class ;
  rdfs:label "Decavac-associated headache AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000067 .

obo:OVAE_0000070 a rdfs:Class ;
  rdfs:label "influenza vaccine adverse event" ;
  rdfs:comment "a virus vaccine adverse event that is associated with administration of an influenza virus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:UBERON_0000111 a rdfs:Class ;
  rdfs:label "organogenesis stage" ;
  rdfs:comment "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/533> ;
  rdfs:subClassOf obo:UBERON_0000067 .

obo:NCBITaxon_11018 a rdfs:Class ;
  rdfs:label "Togaviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35278 .

obo:VO_0000617 a rdfs:Class ;
  rdfs:label "vaccine component role"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OVAE_0000643 a rdfs:Class ;
  rdfs:label "Meruvax II-associated dizziness AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an dizziness AE" ;
  rdfs:subClassOf obo:OAE_0000388 , obo:OVAE_0000033 .

obo:UBERON_0004302 a rdfs:Class ;
  rdfs:label "proximal phalanx" ;
  rdfs:comment "Proximal-most phalanx within a digit." ;
  rdfs:subClassOf obo:UBERON_0003221 .

obo:UBERON_0005726 a rdfs:Class ;
  rdfs:label "chemosensory system" ;
  rdfs:subClassOf obo:UBERON_0001032 .

obo:UBERON_0007500 a rdfs:Class ;
  rdfs:label "epithelial tube open at both ends" ;
  rdfs:comment "An epithelial tube open at both ends that allows fluid flow." ;
  rdfs:subClassOf obo:UBERON_0003914 .

obo:UBERON_0002224 a rdfs:Class ;
  rdfs:label "thoracic cavity" ;
  rdfs:comment "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax." ;
  rdfs:subClassOf obo:UBERON_0000464 .

obo:OVAE_0000485 a rdfs:Class ;
  rdfs:label "Cervarix-associated myalgia AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000064 .

obo:UBERON_0018254 a rdfs:Class ;
  rdfs:label "skeletal musculature" ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0005498 a rdfs:Class ;
  rdfs:label "primitive heart tube" ;
  rdfs:comment "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." ;
  rdfs:subClassOf obo:UBERON_0000481 , obo:UBERON_0002050 , obo:UBERON_0004120 .

obo:UBERON_0011825 a rdfs:Class ;
  rdfs:label "loose connective tissue" ;
  rdfs:comment "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." ;
  rdfs:subClassOf obo:UBERON_0011821 .

obo:NCBITaxon_1385 a rdfs:Class ;
  rdfs:label "Bacillales" ;
  rdfs:subClassOf obo:NCBITaxon_91061 .

obo:OVAE_0000582 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated decreased sleep AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an decreased sleep AE" ;
  rdfs:subClassOf obo:OAE_0001557 , obo:OVAE_0000039 .

obo:UBERON_0001090 a rdfs:Class ;
  rdfs:label "synovial fluid" ;
  rdfs:comment "Transudate contained in the synovial cavity of joints, and in the cavity of tendon sheaths and bursae." ;
  rdfs:subClassOf obo:UBERON_0000463 , obo:UBERON_0007794 .

obo:RO_0003001 a rdf:Property ;
  rdfs:label "produced_by" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:UBERON_0002298 a rdfs:Class ;
  rdfs:label "brainstem" ;
  rdfs:comment "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." ;
  rdfs:subClassOf obo:UBERON_0002616 , obo:UBERON_0010314 .

obo:OAE_0000427 a rdfs:Class ;
  rdfs:label "hemorrhage AE" ;
  rdfs:comment "a cardiovascular disorder AE that has an outcome of hemorrhage" ;
  rdfs:subClassOf obo:OAE_0000493 .

obo:OVAE_0000545 a rdfs:Class ;
  rdfs:label "Menactra-associated anorexia AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an anorexia AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000029 .

obo:UBERON_0000466 a rdfs:Class ;
  rdfs:label "immaterial anatomical entity" ;
  rdfs:comment "Anatomical entity that has no mass." ;
  rdfs:subClassOf obo:UBERON_0001062 .

obo:OVAE_0000516 a rdfs:Class ;
  rdfs:label "Menveo-associated injection-site induration AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000032 .

obo:UBERON_0000064 a rdfs:Class ;
  rdfs:label "organ part" ;
  rdfs:comment "A multicellular structure that is a part of an organ." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:NCBITaxon_1313 a rdfs:Class ;
  rdfs:label "Streptococcus pneumoniae" ;
  rdfs:subClassOf obo:NCBITaxon_1301 .

obo:NCBITaxon_11072 a rdfs:Class ;
  rdfs:label "Japanese encephalitis virus" ;
  rdfs:subClassOf obo:NCBITaxon_11071 .

obo:OBI_0000725 a rdfs:Class ;
  rdfs:label "host role" ;
  rdfs:comment "host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:PATO_0001995 a rdfs:Class ;
  rdfs:label "organismal quality" ;
  rdfs:comment "A quality that inheres in an entire organism or part of an organism." ;
  rdfs:subClassOf obo:PATO_0001237 , obo:PATO_0001241 .

obo:OAE_0000372 a rdfs:Class ;
  rdfs:label "injection-site mass AE" ;
  rdfs:comment "an injection-site AE that display an injection-site mass" ;
  rdfs:subClassOf obo:OAE_0000366 .

obo:VO_0000049 a rdfs:Class ;
  rdfs:label "Gardasil" ;
  rdfs:comment "Product Name: Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine" ;
  rdfs:subClassOf obo:VO_0000667 .

obo:NCBITaxon_11089 a rdfs:Class ;
  rdfs:label "Yellow fever virus" ;
  rdfs:subClassOf obo:NCBITaxon_11051 .

obo:OVAE_0000029 a rdfs:Class ;
  rdfs:label "Menactra vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000079 .

obo:OVAE_0000365 a rdfs:Class ;
  rdfs:label "Pediarix-associated decreased appetite AE" ;
  rdfs:comment "A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000034 .

obo:OVAE_0000470 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated upper respiratory tract infection AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an upper respiratory tract infection AE" ;
  rdfs:subClassOf obo:OAE_0000358 , obo:OVAE_0000042 .

obo:UBERON_0000915 a rdfs:Class ;
  rdfs:label "thoracic segment of trunk" ;
  rdfs:comment "Subdivision of trunk that lies between the head and the abdomen." ;
  rdfs:subClassOf obo:UBERON_0009569 , obo:UBERON_0011676 .

obo:UBERON_0002532 a rdfs:Class ;
  rdfs:label "epiblast (generic)" ;
  rdfs:comment "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]" ;
  rdfs:subClassOf obo:UBERON_0002050 .

obo:VO_0011558 a rdfs:Class ;
  rdfs:label "Ixiaro" ;
  rdfs:subClassOf obo:VO_0000665 .

obo:UBERON_0013702 a rdfs:Class ;
  rdfs:label "body proper" ;
  rdfs:comment "The region of the organism associated with the visceral organs." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:UBERON_0011779 a rdfs:Class ;
  rdfs:label "nerve of head region" ;
  rdfs:comment "A nerve that is part of a head." ;
  rdfs:subClassOf obo:UBERON_0001021 .

obo:UBERON_0003850 a rdfs:Class ;
  rdfs:label "telencephalon neural crest" ;
  rdfs:comment "A neural crest that has_potential_to_developmentally_contribute_to a telencephalon." ;
  rdfs:subClassOf obo:UBERON_0002342 .

obo:OVAE_0000294 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated drowsiness" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000011 .

obo:UBERON_0002101 a rdfs:Class ;
  rdfs:label "limb" ;
  rdfs:comment "A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts." ;
  rdfs:subClassOf obo:UBERON_0000475 , obo:UBERON_0004708 .

obo:OAE_0000325 a rdfs:Class ;
  rdfs:label "injection-site rash AE" ;
  rdfs:comment "injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site" ;
  rdfs:subClassOf obo:OAE_0000362 .

obo:UBERON_0000477 a rdfs:Class ;
  rdfs:label "anatomical cluster" ;
  rdfs:comment "Anatomical group that has its parts adjacent to one another." ;
  rdfs:subClassOf obo:UBERON_0001062 .

obo:OVAE_0000574 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated myalgia AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000037 .

obo:OVAE_0000373 a rdfs:Class ;
  rdfs:label "Pentacel-associated irritability AE" ;
  rdfs:comment "A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000036 .

obo:UBERON_0015061 a rdfs:Class ;
  rdfs:label "limb endochondral element" ;
  rdfs:comment "A limb bone or its cartilage or pre-cartilage precursor." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010363 .

obo:UBERON_0000075 a rdfs:Class ;
  rdfs:label "subdivision of skeletal system" ;
  rdfs:comment "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." ;
  rdfs:subClassOf obo:UBERON_0011216 .

obo:VO_0000736 a rdfs:Class ;
  rdfs:label "Measles-Mumps vaccine" ;
  rdfs:comment "A Measles virus vaccine that also protects against infection with  Mumps virus." ;
  rdfs:subClassOf obo:VO_0000654 .

obo:OVAE_0000280 a rdfs:Class ;
  rdfs:label "FluMist-associated nasal congestion AE" ;
  rdfs:comment "A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an nasal congestion AE" ;
  rdfs:subClassOf obo:OAE_0000335 , obo:OVAE_0000985 .

obo:BFO_0000001 a rdfs:Class ;
  rdfs:label "entity" .

obo:OVAE_0000253 a rdfs:Class ;
  rdfs:label "Fluvirin-associated flu-like syndrome AE" ;
  rdfs:comment "A Fluvirin vaccine adverse event that is associated with an administration of Fluvirin and displays an flu-like syndrome AE" ;
  rdfs:subClassOf obo:OAE_0000399 , obo:OVAE_0000015 .

obo:OVAE_0000454 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated injection-site muscular soreness AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site muscular soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000042 .

obo:OVAE_0000694 a rdfs:Class ;
  rdfs:label "Tenivac-associated joint pain AE" ;
  rdfs:comment "A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an joint pain AE" ;
  rdfs:subClassOf obo:OAE_0001559 , obo:OVAE_0000045 .

obo:OVAE_0000303 a rdfs:Class ;
  rdfs:label "Influenza Virus Vaccine H5N1-associated headache AE" ;
  rdfs:comment "A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000077 , obo:OVAE_0000024 .

obo:OVAE_0000370 a rdfs:Class ;
  rdfs:label "Kinrix-associated drowsiness" ;
  rdfs:comment "A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000028 .

obo:NCBITaxon_10566 a rdfs:Class ;
  rdfs:label "Human papillomavirus" ;
  rdfs:subClassOf obo:NCBITaxon_333774 .

obo:UBERON_0000974 a rdfs:Class ;
  rdfs:label "neck" ;
  rdfs:comment "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." ;
  rdfs:subClassOf obo:UBERON_0000475 .

<http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to> a rdf:Property ;
  rdfs:label "anteriorly connected to" ;
  rdfs:comment "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BSPO_0000099 , obo:RO_0002170 , <http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to> .

<http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to> a rdf:Property ;
  rdfs:label "posteriorly connected to" ;
  rdfs:comment "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002170 , obo:BSPO_0000096 .

obo:OVAE_0000421 a rdfs:Class ;
  rdfs:label "Comvax-associated rhinitis AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rhinitis AE" ;
  rdfs:subClassOf obo:OAE_0000350 , obo:OVAE_0000065 .

obo:NCBITaxon_11050 a rdfs:Class ;
  rdfs:label "Flaviviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35278 .

obo:OAE_0002625 a rdfs:Class ;
  rdfs:label "local AE"@en ;
  rdfs:comment "an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OVAE_0000100 a rdfs:Class ;
  rdfs:label "diphtheria vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of diphtheria vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:VO_0000856 a rdfs:Class ;
  rdfs:label "cell culture residual in vaccine" ;
  rdfs:comment "a vaccine residual that is generatead from cell culture for vaccine preparation. Examples include: antibiotics, sensitizing substances, bacterial and cellular residuals, and adventitious agents." ;
  rdfs:subClassOf obo:VO_0000854 .

obo:OAE_0000600 a rdfs:Class ;
  rdfs:label "nausea AE" ;
  rdfs:comment "an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit"@en ;
  rdfs:subClassOf obo:OAE_0000554 .

obo:UBERON_0010719 a rdfs:Class ;
  rdfs:label "girdle skeleton" ;
  rdfs:comment "The subdivision of the skeleton of either the pectoral or pelvic girdle." ;
  rdfs:subClassOf obo:UBERON_0010912 .

obo:UBERON_0007616 a rdfs:Class ;
  rdfs:label "layer of synovial tissue" ;
  rdfs:comment "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." ;
  rdfs:subClassOf obo:UBERON_0000042 .

obo:OVAE_0000004 a rdfs:Class ;
  rdfs:label "fugal vaccine adverse event" ;
  rdfs:comment "a vaccine adverse event that is associated with administration of a fungal vaccine" ;
  rdfs:subClassOf obo:OAE_0000004 .

obo:OVAE_0000105 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:UBERON_0011137 a rdfs:Class ;
  rdfs:label "axial skeletal system" ;
  rdfs:comment "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton> ;
  rdfs:subClassOf obo:UBERON_0000075 .

obo:NCBITaxon_9606 a rdfs:Class ;
  rdfs:label "Homo sapiens" ;
  rdfs:subClassOf obo:NCBITaxon_314293 .

obo:OVAE_0000381 a rdfs:Class ;
  rdfs:label "ActHIB-associated fever AE" ;
  rdfs:comment "A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000986 .

obo:VO_0000544 a rdfs:Class ;
  rdfs:label "human vaccinee" ;
  rdfs:comment "a vaccinee that is a human being" ;
  rdfs:subClassOf obo:VO_0001374 .

obo:OVAE_0000718 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated hypotension AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an hypotension AE" ;
  rdfs:subClassOf obo:OAE_0000551 , obo:OVAE_0000048 .

obo:UBERON_0001134 a rdfs:Class ;
  rdfs:label "skeletal muscle tissue" ;
  rdfs:comment "Muscle tissue that consists primarily of skeletal muscle fibers." ;
  rdfs:subClassOf obo:CARO_0001008 , obo:UBERON_0002036 .

obo:OVAE_0000320 a rdfs:Class ;
  rdfs:label "Biothrax-associated arm motion limitation AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an arm motion limitation AE" ;
  rdfs:subClassOf obo:OAE_0001548 , obo:OVAE_0000061 .

obo:UBERON_0013701 a rdfs:Class ;
  rdfs:label "main body axis" ;
  rdfs:comment "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:OVAE_0000564 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated diarrhea AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000031 .

obo:OVAE_0000119 a rdfs:Class ;
  rdfs:label "Rotavirus vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Rotavirus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:NCBITaxon_590 a rdfs:Class ;
  rdfs:label "Salmonella" ;
  rdfs:subClassOf obo:NCBITaxon_543 .

obo:UBERON_0005061 a rdfs:Class ;
  rdfs:label "neural groove" ;
  rdfs:comment "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:VO_0000978 a rdfs:Class ;
  rdfs:label "Flublok"@en ;
  rdfs:comment "Trade Name: Flublok" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:UBERON_0000058 a rdfs:Class ;
  rdfs:label "duct" ;
  rdfs:comment "A tubular structure that transports secreted or excreted substances." ;
  rdfs:subClassOf obo:UBERON_0000063 .

obo:OVAE_0000060 a rdfs:Class ;
  rdfs:label "Agriflu vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Agriflu." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:UBERON_0001032 a rdfs:Class ;
  rdfs:label "sensory system" ;
  rdfs:comment "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:VO_0000494 a rdfs:Class ;
  rdfs:label "vaccine immunization" ;
  rdfs:comment "artificial active immunization is an active immunization that occurs when a person or animal is vaccinated with a specific vaccine." ;
  rdfs:subClassOf obo:VO_0000491 .

obo:OBI_0000417 a rdf:Property ;
  rdfs:label "achieves_planned_objective" ;
  rdfs:comment "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000293 a rdf:Property ;
  rdfs:label "has_specified_input" ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:OVAE_0000506 a rdfs:Class ;
  rdfs:label "ProQuad-associated injection-site tenderness AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000040 .

obo:OAE_0000340 a rdfs:Class ;
  rdfs:label "otitis media AE" ;
  rdfs:comment "an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection" ;
  rdfs:subClassOf obo:OAE_0000465 .

obo:UBERON_0001434 a rdfs:Class ;
  rdfs:label "skeletal system" ;
  rdfs:comment "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/The-skeletal-system> ;
  rdfs:subClassOf obo:UBERON_0011216 .

obo:OVAE_0000523 a rdfs:Class ;
  rdfs:label "Menveo-associated malaise AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000032 .

obo:VO_0000912 a rdfs:Class ;
  rdfs:label "chicken egg protein allergen" ;
  rdfs:subClassOf obo:VO_0000910 .

obo:UBERON_0000307 a rdfs:Class ;
  rdfs:label "blastula" ;
  rdfs:comment "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." ;
  rdfs:subClassOf obo:UBERON_0000468 , obo:UBERON_0000922 .

<http://purl.obolibrary.org/obo/uberon/core#existence_starts_and_ends_during> a rdf:Property ;
  rdfs:label "existence starts and ends during" ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002492 , obo:RO_0002488 .

obo:OVAE_0000553 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated injection-site pain AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000031 .

obo:OVAE_0000620 a rdfs:Class ;
  rdfs:label "RabAvert-associated headache AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000041 .

obo:OVAE_0000440 a rdfs:Class ;
  rdfs:label "Vaqta-associated injection-site warmth AE" ;
  rdfs:comment "A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site warmth AE" ;
  rdfs:subClassOf obo:OAE_0000326 , obo:OVAE_0000052 .

obo:UBERON_0000483 a rdfs:Class ;
  rdfs:label "epithelium" ;
  rdfs:comment "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:OVAE_0000578 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated injection-site tenderness AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000039 .

obo:VO_0000646 a rdfs:Class ;
  rdfs:label "Hepatitis A virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Hepatitis A virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:OAE_0000391 a rdfs:Class ;
  rdfs:label "somnolence AE" ;
  rdfs:comment "a behavior and neurological AE that has an outcome of somnolence" ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:UBERON_0003075 a rdfs:Class ;
  rdfs:label "neural plate" ;
  rdfs:comment "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]" ;
  rdfs:subClassOf obo:UBERON_0005291 , obo:UBERON_0010371 , obo:UBERON_0016879 .

obo:UBERON_0002091 a rdfs:Class ;
  rdfs:label "appendicular skeleton" ;
  rdfs:comment "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton> ;
  rdfs:subClassOf obo:UBERON_0010912 .

obo:OAE_0000227 a rdfs:Class ;
  rdfs:label "medical intervention site"@en ;
  rdfs:comment "a site that is used for a medical intervention" ;
  rdfs:subClassOf obo:BFO_0000029 .

obo:VO_0000886 a rdfs:Class ;
  rdfs:label "oral route" ;
  rdfs:subClassOf obo:VO_0000574 .

obo:UBERON_0000068 a rdfs:Class ;
  rdfs:label "embryo stage" ;
  rdfs:comment "A life cycle stage that starts with fertilization and ends with the fully formed embryo." ;
  rdfs:subClassOf obo:UBERON_0000105 .

obo:OVAE_0000541 a rdfs:Class ;
  rdfs:label "Menactra-associated injection-site pain AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000029 .

obo:OVAE_0000065 a rdfs:Class ;
  rdfs:label "Comvax vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000108 .

obo:OVAE_0000631 a rdfs:Class ;
  rdfs:label "Rotarix-associated fever AE" ;
  rdfs:comment "A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000043 .

obo:NCBITaxon_91061 a rdfs:Class ;
  rdfs:label "Bacilli" ;
  rdfs:subClassOf obo:NCBITaxon_1239 .

obo:OVAE_0000738 a rdfs:Class ;
  rdfs:label "Boostrix-associated gastrointestinal disorder AE" ;
  rdfs:comment "A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an gastrointestinal disorder AE" ;
  rdfs:subClassOf obo:OAE_0000455 , obo:OVAE_0000063 .

obo:UBERON_0000487 a rdfs:Class ;
  rdfs:label "simple squamous epithelium" ;
  rdfs:comment "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0000490 , obo:UBERON_0006914 .

obo:OVAE_0000512 a rdfs:Class ;
  rdfs:label "ProQuad-associated rash AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000040 .

obo:UBERON_0000106 a rdfs:Class ;
  rdfs:label "zygote stage" ;
  rdfs:comment "A stage at which the organism is a single cell produced by means of sexual reproduction." ;
  rdfs:subClassOf obo:UBERON_0000067 .

obo:RO_0002223 a rdf:Property ;
  rdfs:label "starts" ;
  rdfs:comment "Relation between occurrents, shares a start boundary with." ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:UBERON_0034705 a rdfs:Class ;
  rdfs:label "developing neuroepithelium" ;
  rdfs:comment "An embryonic or larval epithelium that is committed to form part of the nervous system." ;
  rdfs:subClassOf obo:UBERON_0000483 .

obo:UBERON_0000154 a rdfs:Class ;
  rdfs:label "posterior region of body" ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:UBERON_0002428 a rdfs:Class ;
  rdfs:label "limb bone" ;
  rdfs:comment "A bone that is part of a limb [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0001474 , obo:UBERON_0002513 , obo:UBERON_0004375 , obo:UBERON_0015061 .

obo:OVAE_0000530 a rdfs:Class ;
  rdfs:label "MenHibrix-associated decreased appetite AE" ;
  rdfs:comment "A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000030 .

obo:VO_0000938 a rdfs:Class ;
  rdfs:label "xanthan gum vaccine ajuvant" ;
  rdfs:subClassOf obo:VO_0001357 .

obo:VO_0000897 a rdfs:Class ;
  rdfs:label "age at vaccination" ;
  rdfs:comment "Age at vaccination is the age of an experiment animal at the time of vaccination." ;
  rdfs:subClassOf obo:PATO_0000165 .

obo:OVAE_0000549 a rdfs:Class ;
  rdfs:label "Menactra-associated headache AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000029 .

obo:UBERON_0002390 a rdfs:Class ;
  rdfs:label "hematopoietic system" ;
  rdfs:comment "Anatomical system that is involved in the production of hematopoietic cells." ;
  rdfs:subClassOf obo:UBERON_0000467 , obo:UBERON_0004120 .

obo:VO_0000005 a rdfs:Class ;
  rdfs:label "Adacel" ;
  rdfs:comment "Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed" ;
  rdfs:subClassOf obo:VO_0000738 .

obo:UBERON_0000383 a rdfs:Class ;
  rdfs:label "musculature of body" ;
  rdfs:comment "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." ;
  rdfs:subClassOf obo:UBERON_0011216 .

obo:OVAE_0000604 a rdfs:Class ;
  rdfs:label "IPOL-associated crying abnormal AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an crying abnormal AE" ;
  rdfs:subClassOf obo:OAE_0000393 , obo:OVAE_0000025 .

obo:OVAE_0000242 a rdfs:Class ;
  rdfs:label "Flucelvax-associated injection-site pain AE" ;
  rdfs:comment "A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000012 .

obo:OVAE_0000025 a rdfs:Class ;
  rdfs:label "IPOL vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000116 .

obo:OVAE_0000683 a rdfs:Class ;
  rdfs:label "Decavac-associated diarrhea AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000067 .

obo:OVAE_0000687 a rdfs:Class ;
  rdfs:label "Tenivac-associated injection-site pain AE" ;
  rdfs:comment "A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000045 .

obo:OVAE_0000657 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated injection-site tenderness AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000046 .

obo:OAE_0000543 a rdfs:Class ;
  rdfs:label "skin AE" ;
  rdfs:comment "a hair, skin, and nail AE that occurs in skin." ;
  rdfs:subClassOf obo:OAE_0000199 .

obo:OVAE_0000238 a rdfs:Class ;
  rdfs:label "Flublok-associated injection-site pain AE" ;
  rdfs:comment "A Flublok vaccine adverse event that is associated with an administration of Flublok and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000009 .

obo:BFO_0000004 a rdfs:Class ;
  rdfs:label "independent continuant"@en ;
  rdfs:comment "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:OVAE_0000748 a rdfs:Class ;
  rdfs:label "Vivotif-associated headache AE" ;
  rdfs:comment "A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000054 .

obo:OVAE_0000481 a rdfs:Class ;
  rdfs:label "Cervarix-associated injection-site redness AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000064 .

obo:OVAE_0000750 a rdfs:Class ;
  rdfs:label "Vivotif-associated diarrhea AE" ;
  rdfs:comment "A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000054 .

obo:UBERON_0000109 a rdfs:Class ;
  rdfs:label "gastrula stage" ;
  rdfs:comment "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." ;
  rdfs:subClassOf obo:UBERON_0000067 .

obo:BFO_0000015 a rdfs:Class ;
  rdfs:label "process"@en ;
  rdfs:comment "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:OVAE_0000357 a rdfs:Class ;
  rdfs:label "Daptacel-associated lethargy AE" ;
  rdfs:comment "A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an lethargy AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000066 .

obo:OVAE_0000462 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated skin nodule AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an skin nodule AE" ;
  rdfs:subClassOf obo:OAE_0000419 , obo:OVAE_0000042 .

obo:OVAE_0000672 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated rash AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000046 .

obo:NCBITaxon_1717 a rdfs:Class ;
  rdfs:label "Corynebacterium diphtheriae" ;
  rdfs:subClassOf obo:NCBITaxon_85007 .

obo:OVAE_0000217 a rdfs:Class ;
  rdfs:label "Flulaval-associated injection-site pain AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000013 .

obo:OVAE_0000761 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated diarrhea AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000051 .

obo:VO_0000662 a rdfs:Class ;
  rdfs:label "Haemophilus influenzae serotype b vaccine" ;
  rdfs:subClassOf obo:VO_0012185 .

obo:UBERON_0005769 a rdfs:Class ;
  rdfs:label "basement membrane of epithelium" ;
  rdfs:comment "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina." ;
  rdfs:subClassOf obo:UBERON_0005764 .

obo:OAE_0000361 a rdfs:Class ;
  rdfs:label "fever AE" ;
  rdfs:comment "an abnormal body temperature AE which has an outcome of fever" ;
  rdfs:subClassOf obo:OAE_0000624 .

obo:NCBITaxon_33154 a rdfs:Class ;
  rdfs:label "Opisthokonta" ;
  rdfs:subClassOf obo:NCBITaxon_2759 .

obo:OAE_0001550 a rdfs:Class ;
  rdfs:label "sleepiness AE"@en ;
  rdfs:comment "a sleep disorder AE that shows up sleepiness (Sluggish from sleep, inactive, quiet)." ;
  rdfs:subClassOf obo:OAE_0001403 .

obo:UBERON_0001895 a rdfs:Class ;
  rdfs:label "metencephalon" ;
  rdfs:comment "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." ;
  rdfs:subClassOf obo:UBERON_0004733 .

obo:OVAE_0000666 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated headache AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000046 .

obo:UBERON_0004139 a rdfs:Class ;
  rdfs:label "cardiogenic plate" ;
  rdfs:comment "The first recognizable structure derived from the heart field" ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:OVAE_0000249 a rdfs:Class ;
  rdfs:label "Flucelvax-associated fatigue AE" ;
  rdfs:comment "A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000012 .

obo:UBERON_0011821 a rdfs:Class ;
  rdfs:label "irregular connective tissue" ;
  rdfs:comment "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." ;
  rdfs:subClassOf obo:UBERON_0002384 .

obo:UBERON_0001013 a rdfs:Class ;
  rdfs:label "adipose tissue" ;
  rdfs:comment "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue" ;
  rdfs:subClassOf obo:UBERON_0011822 .

obo:OVAE_0000368 a rdfs:Class ;
  rdfs:label "Kinrix-associated injection-site edema AE" ;
  rdfs:comment "A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0001553 , obo:OVAE_0000028 .

obo:UBERON_0009768 a rdfs:Class ;
  rdfs:label "distal interphalangeal joint" ;
  rdfs:comment "An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx." ;
  rdfs:subClassOf obo:UBERON_0006658 .

obo:OVAE_0000264 a rdfs:Class ;
  rdfs:label "Fluzone-associated myalgia AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000016 .

obo:UBERON_0002416 a rdfs:Class ;
  rdfs:label "integumental system" ;
  rdfs:comment "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OVAE_0000698 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated injection-site induration AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000047 .

obo:OVAE_0000048 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000100 .

obo:OVAE_0000708 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated injection-site redness AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000048 .

obo:UBERON_0002405 a rdfs:Class ;
  rdfs:label "immune system" ;
  rdfs:comment "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." ;
  rdfs:subClassOf obo:UBERON_0000467 .

<http://purl.obolibrary.org/obo/uberon/core#protects> a rdf:Property ;
  rdfs:label "protects" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000015 a rdfs:Class ;
  rdfs:label "Fluvirin vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Fluvirin." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:OAE_0000571 a rdfs:Class ;
  rdfs:label "abnormal respiration AE" ;
  rdfs:comment "a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung"@en ;
  rdfs:subClassOf obo:OAE_0000378 .

obo:OVAE_0000567 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated injection-site tenderness AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000037 .

obo:VO_0000111 a rdfs:Class ;
  rdfs:label "Tetanus and Diphtheria Toxoids Adsorbed by MA Biologic Lab" ;
  rdfs:comment "Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use" ;
  rdfs:subClassOf obo:VO_0000732 .

obo:OVAE_0000679 a rdfs:Class ;
  rdfs:label "Decavac-associated injection-site erythema AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000067 .

obo:OVAE_0000410 a rdfs:Class ;
  rdfs:label "Comvax-associated injection-site erythema AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000065 .

obo:OAE_0000582 a rdfs:Class ;
  rdfs:label "sensory capability AE" ;
  rdfs:comment "a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus"@en ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:OAE_0000351 a rdfs:Class ;
  rdfs:label "rhinorrhea AE" ;
  rdfs:comment "rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid" ;
  rdfs:subClassOf obo:OAE_0000378 .

obo:VO_0000097 a rdfs:Class ;
  rdfs:label "RotaTeq" ;
  rdfs:comment "Trade Name: RotaTeq" ;
  rdfs:subClassOf obo:VO_0000658 .

obo:UBERON_0012354 a rdfs:Class ;
  rdfs:label "acropodium region" ;
  rdfs:comment "The segment of the autopod that is distal to the metapodial region and consists of the digits." ;
  rdfs:subClassOf obo:UBERON_0012139 .

obo:OVAE_0000379 a rdfs:Class ;
  rdfs:label "ActHIB-associated injection-site redness AE" ;
  rdfs:comment "A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000986 .

obo:OVAE_0000720 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated arthralgia AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000048 .

obo:OAE_0001838 a rdfs:Class ;
  rdfs:label "AE severity G3"@en ;
  rdfs:comment "a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet)." ;
  rdfs:subClassOf obo:OAE_0001750 .

obo:OVAE_0000615 a rdfs:Class ;
  rdfs:label "RabAvert-associated injection-site induration AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000041 .

obo:VO_0000278 a rdfs:Class ;
  rdfs:label "vaccine function" ;
  rdfs:comment "vaccine function is a function that inheres in a vaccine that induces protective immune response against a disease. It is realized in the immunization process in the host."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OVAE_0000653 a rdfs:Class ;
  rdfs:label "ACAM2000-associated fever AE" ;
  rdfs:comment "A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000987 .

obo:UBERON_0001137 a rdfs:Class ;
  rdfs:label "dorsum" ;
  rdfs:comment "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:OVAE_0000664 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated malaise AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000046 .

obo:CHEBI_30911 a rdfs:Class ;
  rdfs:label "glucitol" ;
  rdfs:subClassOf obo:CHEBI_23367 .

obo:VO_0000211 a rdfs:Class ;
  rdfs:label "vaccine organism inactivated" ;
  rdfs:comment "an organismal quality of a whole organism vaccine where the whole organism is inactivated/killed and lacks the capability of replication. " ;
  rdfs:subClassOf obo:VO_0001139 .

obo:OVAE_0000201 a rdfs:Class ;
  rdfs:label "Afluria-associated injection-site pain AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000984 .

obo:UBERON_0001705 a rdfs:Class ;
  rdfs:label "nail" ;
  rdfs:comment "A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]." ;
  rdfs:subClassOf obo:UBERON_0009564 .

obo:OVAE_0000443 a rdfs:Class ;
  rdfs:label "Twinrix-associated injection-site redness AE" ;
  rdfs:comment "A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000050 .

obo:OVAE_0000984 a rdfs:Class ;
  rdfs:label "Afluria vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Afluria." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:VO_0000498 a rdfs:Class ;
  rdfs:label "modification of adaptive immune response to antigen" ;
  rdfs:comment "modification of adaptive immune response to antigen is an active immunization process that results in modification of an adaptive immune response to some antigens, for example, in a therapeutic vaccine." ;
  rdfs:subClassOf obo:VO_0000491 .

obo:OVAE_0000307 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated headache AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000074 .

obo:UBERON_0009581 a rdfs:Class ;
  rdfs:label "midbrain mantle layer" ;
  rdfs:subClassOf obo:UBERON_0004061 .

obo:UBERON_0000014 a rdfs:Class ;
  rdfs:label "zone of skin" ;
  rdfs:comment "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0034944 .

obo:OVAE_0000534 a rdfs:Class ;
  rdfs:label "Menactra-associated local swelling AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000029 .

obo:OVAE_0000404 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated upper respiratory tract infection AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an upper respiratory tract infection AE" ;
  rdfs:subClassOf obo:OAE_0000358 , obo:OVAE_0000035 .

obo:BFO_0000028 a rdfs:Class ;
  rdfs:label "three-dimensional spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000006 .

obo:OVAE_0000502 a rdfs:Class ;
  rdfs:label "JE-Vax-associated nausea AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000027 .

obo:OAE_0001139 a rdfs:Class ;
  rdfs:label "localized edema AE" ;
  rdfs:comment "an edema AE occuring in a specific region" ;
  rdfs:subClassOf obo:OAE_0000556 .

obo:UBERON_0001557 a rdfs:Class ;
  rdfs:label "upper respiratory tract" ;
  rdfs:comment "The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea." ;
  rdfs:subClassOf obo:UBERON_0000072 .

obo:CHEBI_23367 a rdfs:Class ;
  rdfs:label "molecular entity" ;
  rdfs:comment "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." ;
  rdfs:subClassOf obo:CHEBI_24431 .

obo:OVAE_0000716 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated fever AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000048 .

obo:OVAE_0000115 a rdfs:Class ;
  rdfs:label "Measles-Mumps-Rubella-Vericella vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Measles-Mumps-Rubella-Vericella vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:VO_0000435 a rdfs:Class ;
  rdfs:label "DNA vaccine plasmid vector" ;
  rdfs:comment "a vaccine component that is composed of a plasmid and used in the generation of a DNA vaccine. " ;
  rdfs:subClassOf obo:VO_0000179 .

obo:UBERON_0004060 a rdfs:Class ;
  rdfs:label "neural tube ventricular layer" ;
  rdfs:comment "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium" ;
  rdfs:subClassOf obo:UBERON_0005291 , obo:UBERON_0010371 , obo:UBERON_0034706 .

obo:OVAE_0000492 a rdfs:Class ;
  rdfs:label "JE-Vax-associated injection-site tenderness AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000027 .

obo:NCBITaxon_712 a rdfs:Class ;
  rdfs:label "Pasteurellaceae" ;
  rdfs:subClassOf obo:NCBITaxon_1236 .

obo:OVAE_0000206 a rdfs:Class ;
  rdfs:label "Afluria-associated malaise AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000984 .

obo:UBERON_0005764 a rdfs:Class ;
  rdfs:label "acellular membrane" ;
  rdfs:comment "A acellular anatomical structure that is the bounding layer of a anatomical structure." ;
  rdfs:subClassOf obo:UBERON_0000476 .

obo:UBERON_0000170 a rdfs:Class ;
  rdfs:label "pair of lungs" ;
  rdfs:comment "The pair of anatomical structures comprised of a left lung and right lung." ;
  rdfs:subClassOf obo:UBERON_0034925 .

obo:OAE_0000034 a rdfs:Class ;
  rdfs:label "fatigue AE" ;
  rdfs:comment "a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities." ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:OVAE_0000351 a rdfs:Class ;
  rdfs:label "Infanrix-associated decreased appetite AE" ;
  rdfs:comment "A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000023 .

obo:OAE_0000216 a rdfs:Class ;
  rdfs:label "unusual high-pitched crying AE"@en ;
  rdfs:comment "a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient" ;
  rdfs:subClassOf obo:OAE_0000393 .

obo:CHEBI_16842 a rdfs:Class ;
  rdfs:label "formaldehyde" ;
  rdfs:comment "The simplest aldehyde." ;
  rdfs:subClassOf obo:CHEBI_23367 .

obo:UBERON_0009618 a rdfs:Class ;
  rdfs:label "trunk paraxial mesoderm" ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005256 .

obo:UBERON_0001007 a rdfs:Class ;
  rdfs:label "digestive system" ;
  rdfs:comment "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:VO_0000853 a rdfs:Class ;
  rdfs:label "vaccine stabilizer" ;
  rdfs:comment "a vaccine additive that helps to protect the vaccine from adverse conditions such as the freeze-drying process (for those vaccines that are freeze-dried) or heat." ;
  rdfs:subClassOf obo:VO_0000179 .

obo:OVAE_0000392 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated injection-site pain AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000035 .

obo:UBERON_0005906 a rdfs:Class ;
  rdfs:label "serous sac" ;
  rdfs:comment "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:UBERON_0000923 a rdfs:Class ;
  rdfs:label "germ layer" ;
  rdfs:comment "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." ;
  rdfs:subClassOf obo:UBERON_0010316 .

obo:OVAE_0000556 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated diarrhea AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000031 .

obo:OVAE_0000037 a rdfs:Class ;
  rdfs:label "Pneumovax 23 vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000078 .

obo:OVAE_0000342 a rdfs:Class ;
  rdfs:label "Tripedia-associated vomiting AE" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000049 .

obo:UBERON_0005162 a rdfs:Class ;
  rdfs:label "multi cell part structure" ;
  rdfs:comment "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." ;
  rdfs:subClassOf obo:UBERON_0000477 .

obo:OVAE_0000451 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated fatigue AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000042 .

obo:OVAE_0000642 a rdfs:Class ;
  rdfs:label "Meruvax II-associated headache AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000033 .

obo:UBERON_0002342 a rdfs:Class ;
  rdfs:label "neural crest" ;
  rdfs:comment "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0010314 , obo:UBERON_0010316 .

obo:UBERON_0004301 a rdfs:Class ;
  rdfs:label "middle phalanx" ;
  rdfs:comment "A phalanx located between proximal and distal phalanges." ;
  rdfs:subClassOf obo:UBERON_0003221 .

obo:OAE_0001549 a rdfs:Class ;
  rdfs:label "injection-site muscular soreness AE"@en ;
  rdfs:comment "a sensory capability AE that shows up muscular soreness at the injection site of a medical intervention" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:VO_0000934 a rdfs:Class ;
  rdfs:label "sorbitol vaccine stabilizer" ;
  rdfs:comment "a vaccine stabilizer that is specifically made by sorbitol." ;
  rdfs:subClassOf obo:VO_0003034 .

obo:OVAE_0000212 a rdfs:Class ;
  rdfs:label "Afluria-associated muscle ache AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an muscle ache AE" ;
  rdfs:subClassOf obo:OAE_0000383 , obo:OVAE_0000984 .

obo:OVAE_0000432 a rdfs:Class ;
  rdfs:label "Havrix-associated decreased appetite AE" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000020 .

obo:UBERON_0006603 a rdfs:Class ;
  rdfs:label "presumptive mesoderm" ;
  rdfs:comment "Presumptive structure of the blastula that will develop into mesoderm." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:VO_0000452 a rdfs:Class ;
  rdfs:label "preventive vaccine function" ;
  rdfs:comment "preventive vaccine function is a vaccine function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which protects against a specific disorder." ;
  rdfs:subClassOf obo:VO_0000278 .

obo:UBERON_0001456 a rdfs:Class ;
  rdfs:label "face" ;
  rdfs:comment "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." ;
  rdfs:subClassOf obo:UBERON_0001444 .

obo:UBERON_0000094 a rdfs:Class ;
  rdfs:label "membrane organ" ;
  rdfs:comment "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]" ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:UBERON_0004381 a rdfs:Class ;
  rdfs:label "skeleton of limb" ;
  rdfs:comment "The collection of all skeletal elements in an individual limb." ;
  rdfs:subClassOf obo:UBERON_0010712 , obo:UBERON_0010912 , obo:UBERON_0011582 .

obo:NCBITaxon_11041 a rdfs:Class ;
  rdfs:label "Rubella virus" ;
  rdfs:subClassOf obo:NCBITaxon_11018 .

obo:OVAE_0000575 a rdfs:Class ;
  rdfs:label "Prevnar-associated injection-site erythema AE" ;
  rdfs:comment "A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000038 .

obo:UBERON_0006914 a rdfs:Class ;
  rdfs:label "squamous epithelium" ;
  rdfs:comment "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells." ;
  rdfs:subClassOf obo:UBERON_0000483 .

obo:CHEBI_24431 a rdfs:Class ;
  rdfs:label "chemical entity" ;
  rdfs:comment "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0004291 a rdfs:Class ;
  rdfs:label "heart rudiment" ;
  rdfs:comment "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." ;
  rdfs:subClassOf obo:UBERON_0012275 .

obo:OVAE_0000426 a rdfs:Class ;
  rdfs:label "Havrix-associated headache AE" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000020 .

obo:OAE_0000201 a rdfs:Class ;
  rdfs:label "nail AE" ;
  rdfs:comment "a hair, skin, and nail AE that occurs in nail." ;
  rdfs:subClassOf obo:OAE_0000199 .

obo:VO_0000218 a rdfs:Class ;
  rdfs:label "hypersensitivity to chicken egg" ;
  rdfs:subClassOf obo:VO_0000213 .

obo:UBERON_0007651 a rdfs:Class ;
  rdfs:label "anatomical junction" ;
  rdfs:comment "An anatomical structure that connects two structures" ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0002072 a rdfs:Class ;
  rdfs:label "hypodermis" ;
  rdfs:comment "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." ;
  rdfs:subClassOf obo:CARO_0001008 , obo:UBERON_0004120 , obo:UBERON_0013754 .

obo:VO_0000064 a rdfs:Class ;
  rdfs:label "Infanrix" ;
  rdfs:comment "Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed" ;
  rdfs:subClassOf obo:VO_0000738 .

obo:OVAE_0000622 a rdfs:Class ;
  rdfs:label "RabAvert-associated malaise AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000041 .

obo:OVAE_0000362 a rdfs:Class ;
  rdfs:label "Pediarix-associated fever AE" ;
  rdfs:comment "A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000034 .

obo:VO_0000002 a rdfs:Class ;
  rdfs:label "vaccination" ;
  rdfs:comment "a process of administering substance in vivo that involves in adding a vaccine into a host (e.g., human) in vivo with the intent to invoke a protective or therapeutic adaptive immune response." ;
  rdfs:subClassOf obo:OAE_0000002 , obo:OBI_0600007 .

obo:OVAE_0000026 a rdfs:Class ;
  rdfs:label "Ixiaro vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000113 .

obo:OVAE_0000769 a rdfs:Class ;
  rdfs:label "YF-Vax-associated headache AE" ;
  rdfs:comment "A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000055 .

obo:CHEBI_17716 a rdfs:Class ;
  rdfs:label "lactose" ;
  rdfs:comment "A disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form." ;
  rdfs:subClassOf obo:CHEBI_23367 .

obo:UBERON_0005733 a rdfs:Class ;
  rdfs:label "limb field" ;
  rdfs:comment "A ring of cells capable of forming a limb." ;
  rdfs:subClassOf obo:UBERON_0005732 .

obo:UBERON_0010130 a rdfs:Class ;
  rdfs:label "autopod plate" ;
  rdfs:comment "The distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. manus, pes, paw)" ;
  rdfs:subClassOf obo:UBERON_0002050 , obo:UBERON_0006598 .

obo:OVAE_0000223 a rdfs:Class ;
  rdfs:label "Fluarix-associated drowsiness" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000010 .

obo:OVAE_0000646 a rdfs:Class ;
  rdfs:label "Meruvax II-associated vasculitis AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an vasculitis AE" ;
  rdfs:subClassOf obo:OAE_0000565 , obo:OVAE_0000033 .

obo:VO_0011559 a rdfs:Class ;
  rdfs:label "Cervarix" ;
  rdfs:subClassOf obo:VO_0000667 .

obo:BFO_0000008 a rdfs:Class ;
  rdfs:label "temporal region"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:BFO_0000154 a rdf:Property ;
  rdfs:label "temporal projection of spatiotemporal"@en ;
  rdfs:domain obo:BFO_0000008 ;
  rdfs:range obo:BFO_0000011 ;
  rdfs:subPropertyOf obo:BFO_0000157 .

obo:BFO_0000156 a rdf:Property ;
  rdfs:label "has temporal occupant"@en ;
  rdfs:domain obo:BFO_0000008 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:BFO_0000157 .

obo:BFO_0000157 a rdf:Property ;
  rdfs:label "during which exists"@en ;
  rdfs:domain obo:BFO_0000008 ;
  rdfs:range obo:BFO_0000001 .

obo:UBERON_0001780 a rdfs:Class ;
  rdfs:label "spinal nerve" ;
  rdfs:comment "the any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]" ;
  rdfs:subClassOf obo:UBERON_0001021 .

obo:OVAE_0000752 a rdfs:Class ;
  rdfs:label "Vivotif-associated rash AE" ;
  rdfs:comment "A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000054 .

obo:UBERON_0002268 a rdfs:Class ;
  rdfs:label "olfactory organ" ;
  rdfs:comment "An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ." ;
  rdfs:subClassOf obo:UBERON_0000020 .

obo:OVAE_0000572 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated asthenia AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an asthenia AE" ;
  rdfs:subClassOf obo:OAE_0000382 , obo:OVAE_0000037 .

obo:OVAE_0000003 a rdfs:Class ;
  rdfs:label "parasite vaccine adverse event" ;
  rdfs:comment "a vaccine adverse event that is associated with administration of a parasite vaccine" ;
  rdfs:subClassOf obo:OAE_0000004 .

obo:VO_0000884 a rdfs:Class ;
  rdfs:label "aluminum vaccine adjuvant" ;
  rdfs:comment "a mineral salt vaccine adjuvant that is composed of aluminum salt." ;
  rdfs:subClassOf obo:VO_0000093 .

obo:UBERON_0004347 a rdfs:Class ;
  rdfs:label "limb bud" ;
  rdfs:comment "An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." ;
  rdfs:subClassOf obo:UBERON_0004357 .

obo:UBERON_0007503 a rdfs:Class ;
  rdfs:label "epithelial vesicle" ;
  rdfs:comment "A closed epithelium with a lumen." ;
  rdfs:subClassOf obo:UBERON_0000483 .

obo:OVAE_0000239 a rdfs:Class ;
  rdfs:label "Flublok-associated headache AE" ;
  rdfs:comment "A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000009 .

obo:UBERON_0009881 a rdfs:Class ;
  rdfs:label "anterior lateral plate mesoderm" ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005291 .

obo:UBERON_0005409 a rdfs:Class ;
  rdfs:label "alimentary part of gastrointestinal system" ;
  rdfs:comment "The part of the digestive system that excludes the hepatobiliary system." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:UBERON_5002544 a rdfs:Class ;
  rdfs:label "digit plus metapodial segment" ;
  rdfs:comment "A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:VO_0000165 a rdfs:Class ;
  rdfs:label "bacterial vaccine" ;
  rdfs:comment "A vaccine that targets against a bacterial disease." ;
  rdfs:subClassOf obo:VO_0000001 .

obo:OVAE_0000035 a rdfs:Class ;
  rdfs:label "PedvaxHIB vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000072 .

obo:OBI_0000011 a rdfs:Class ;
  rdfs:label "planned process"@en ;
  rdfs:comment "A processual entity that realizes a plan which is the concretization of a plan specification."@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0000066 a rdfs:Class ;
  rdfs:label "JE-Vax" ;
  rdfs:comment "Trade Name: JE-Vax" ;
  rdfs:subClassOf obo:VO_0000665 .

obo:OVAE_0000335 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated nausea AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000007 .

obo:OVAE_0000116 a rdfs:Class ;
  rdfs:label "Poliovirus vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Poliovirus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:OVAE_0000408 a rdfs:Class ;
  rdfs:label "Comvax-associated local swelling AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000065 .

obo:UBERON_0010702 a rdfs:Class ;
  rdfs:label "digit mesenchyme" ;
  rdfs:comment "Mesenchyme of the digit region." ;
  rdfs:subClassOf obo:UBERON_0003104 , obo:UBERON_0009749 .

obo:OAE_0000343 a rdfs:Class ;
  rdfs:label "pharyngitis AE" ;
  rdfs:comment "pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx" ;
  rdfs:subClassOf obo:OAE_0000439 .

obo:OVAE_0000267 a rdfs:Class ;
  rdfs:label "Fluzone High-Dose-associated headache AE" ;
  rdfs:comment "A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000017 .

obo:VO_0000015 a rdfs:Class ;
  rdfs:label "Boostrix" ;
  rdfs:comment "Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed" ;
  rdfs:subClassOf obo:VO_0000738 .

obo:OVAE_0000649 a rdfs:Class ;
  rdfs:label "Meruvax II-associated nausea AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000033 .

obo:OVAE_0000220 a rdfs:Class ;
  rdfs:label "Flulaval-associated fatigue AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000013 .

obo:OAE_0000366 a rdfs:Class ;
  rdfs:label "injection-site AE" ;
  rdfs:comment "injection-site AE is an AE that occurs in an injection site (e.g., during vaccination)." ;
  rdfs:subClassOf obo:OAE_0000226 , obo:OAE_0002625 .

obo:IAO_0000033 a rdfs:Class ;
  rdfs:label "directive information entity"@en ;
  rdfs:comment "An information content entity whose concretizations indicate to their bearer how to realize them in a process."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OVAE_0000420 a rdfs:Class ;
  rdfs:label "Comvax-associated cough" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an cough" ;
  rdfs:subClassOf obo:OAE_0000398 , obo:OVAE_0000065 .

obo:BFO_0000002 a rdfs:Class ;
  rdfs:label "continuant" ;
  rdfs:comment "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ;
  rdfs:subClassOf obo:BFO_0000001 .

obo:OVAE_0000419 a rdfs:Class ;
  rdfs:label "Comvax-associated rhinorrhea AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rhinorrhea AE" ;
  rdfs:subClassOf obo:OAE_0000351 , obo:OVAE_0000065 .

obo:OVAE_0000441 a rdfs:Class ;
  rdfs:label "Vaqta-associated headache AE" ;
  rdfs:comment "A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000052 .

obo:UBERON_0003914 a rdfs:Class ;
  rdfs:label "epithelial tube" ;
  rdfs:comment "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." ;
  rdfs:subClassOf obo:UBERON_0000025 , obo:UBERON_0000483 .

obo:VO_0000486 a rdfs:Class ;
  rdfs:label "chicken ovalbumin egg protein allergen"@en ;
  rdfs:subClassOf obo:VO_0000912 .

obo:OVAE_0000638 a rdfs:Class ;
  rdfs:label "RotaTeq-associated nasopharyngitis AE" ;
  rdfs:comment "A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an nasopharyngitis AE" ;
  rdfs:subClassOf obo:OAE_0000336 , obo:OVAE_0000044 .

obo:OVAE_0000460 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated local swelling AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000042 .

obo:OVAE_0000032 a rdfs:Class ;
  rdfs:label "Menveo vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000079 .

obo:OVAE_0000332 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated fever AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000007 .

obo:OAE_0000199 a rdfs:Class ;
  rdfs:label "hair, skin or nail AE" ;
  rdfs:comment "an adverse event that occurs in hair, skin, or nail." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OVAE_0000256 a rdfs:Class ;
  rdfs:label "Fluzone-associated irritability AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000016 .

obo:UBERON_0034873 a rdfs:Class ;
  rdfs:label "bodily gas" ;
  rdfs:comment "Any substance in the body or expelled from the body that is in a gaseous state." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OVAE_0000601 a rdfs:Class ;
  rdfs:label "IPOL-associated irritability AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000025 .

obo:NCBITaxon_197912 a rdfs:Class ;
  rdfs:label "Influenzavirus B" ;
  rdfs:subClassOf obo:NCBITaxon_11308 .

obo:OAE_0000785 a rdfs:Class ;
  rdfs:label "cardiomyopathy AE" ;
  rdfs:comment "a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure" ;
  rdfs:subClassOf obo:OAE_0000084 .

obo:OVAE_0000043 a rdfs:Class ;
  rdfs:label "Rotarix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000119 .

obo:UBERON_0003050 a rdfs:Class ;
  rdfs:label "olfactory placode" ;
  rdfs:comment "A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity." ;
  rdfs:subClassOf obo:UBERON_0009955 .

obo:OAE_0001560 a rdfs:Class ;
  rdfs:label "tiredness AE" ;
  rdfs:comment "Tiredness AE is a sensory capability AE that results in a sensation of tiredness." ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:VO_0000496 a rdfs:Class ;
  rdfs:label "disorder prevention" ;
  rdfs:comment "disorder prevention is a processual entity that prevents a disorder that is the physical basis of a disease." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:UBERON_0002050 a rdfs:Class ;
  rdfs:label "embryonic structure" ;
  rdfs:comment "Anatomical structure that is part of an embryo." ;
  rdfs:subClassOf obo:UBERON_0000061 , obo:UBERON_0005423 .

obo:OVAE_0000270 a rdfs:Class ;
  rdfs:label "Fluzone High-Dose-associated malaise AE" ;
  rdfs:comment "A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000017 .

obo:OVAE_0000046 a rdfs:Class ;
  rdfs:label "adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological" ;
  rdfs:subClassOf obo:OVAE_0000101 .

obo:OVAE_0000074 a rdfs:Class ;
  rdfs:label "adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral"@en ;
  rdfs:comment "an adenovirus vaccine adverse event that is associated with administration of an adenovirus vaccine Adenovirus Type 4 and Type 7 Vaccine, Live, Oral" ;
  rdfs:subClassOf obo:OVAE_0000073 .

obo:VO_0000088 a rdfs:Class ;
  rdfs:label "Pneumovax 23 (USA)" ;
  rdfs:comment "Trade Name: Pneumovax 23" ;
  rdfs:subClassOf obo:VO_0000424 .

obo:OVAE_0000328 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated local swelling AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000007 .

obo:VO_0000497 a rdfs:Class ;
  rdfs:label "disorder treatment" ;
  rdfs:comment "disorder treatment is a processual entity that leads to treat a disorder that is the physical basis of a disease." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OAE_0000455 a rdfs:Class ;
  rdfs:label "gastrointestinal disorder AE" ;
  rdfs:comment "a digestive system AE which has an outcome of a gastrointestinal disorder" ;
  rdfs:subClassOf obo:OAE_0000439 .

obo:OVAE_0000765 a rdfs:Class ;
  rdfs:label "Varivax-associated fever AE" ;
  rdfs:comment "A Varivax vaccine adverse event that is associated with an administration of Varivax and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000053 .

obo:OVAE_0000626 a rdfs:Class ;
  rdfs:label "RabAvert-associated nausea AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000041 .

obo:OVAE_0000586 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated injection-site pain AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000039 .

obo:OVAE_0000537 a rdfs:Class ;
  rdfs:label "Menactra-associated drowsiness" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000029 .

obo:UBERON_0003061 a rdfs:Class ;
  rdfs:label "blood island" ;
  rdfs:comment "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:UBERON_0002167 a rdfs:Class ;
  rdfs:label "right lung" ;
  rdfs:comment "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0002048 .

obo:BSPO_0000121 a rdf:Property ;
  rdfs:label "in_right_side_of" ;
  rdfs:comment "X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BSPO_0000126 .

obo:BSPO_0000126 a rdf:Property ;
  rdfs:label "in_lateral_side_of" ;
  rdfs:comment "X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure" ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:VO_0000037 a rdfs:Class ;
  rdfs:label "adenovirus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection of an adenovirus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:UBERON_0000061 a rdfs:Class ;
  rdfs:label "anatomical structure" ;
  rdfs:comment "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:VO_0000341 a rdfs:Class ;
  rdfs:label "intranasal route" ;
  rdfs:comment "rounte of administration that located in nose." ;
  rdfs:subClassOf obo:VO_0000574 .

obo:OVAE_0000277 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated myalgia AE" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000018 .

obo:OVAE_0000383 a rdfs:Class ;
  rdfs:label "ActHIB-associated lethargy AE" ;
  rdfs:comment "A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an lethargy AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000986 .

obo:OAE_0001558 a rdfs:Class ;
  rdfs:label "increased sleep AE"@en ;
  rdfs:comment "a sleep disorder AE that shows increased sleep" ;
  rdfs:subClassOf obo:OAE_0001403 .

obo:OVAE_0000662 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated oedema, swelling dropsy" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an oedema, swelling dropsy" ;
  rdfs:subClassOf obo:OAE_0000556 , obo:OVAE_0000046 .

obo:OVAE_0000702 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated malaise AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000047 .

obo:OVAE_0000447 a rdfs:Class ;
  rdfs:label "Engerix-B-associated fatigue AE" ;
  rdfs:comment "A Engerix-B vaccine adverse event that is associated with an administration of Engerix-B and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000008 .

obo:OVAE_0000509 a rdfs:Class ;
  rdfs:label "ProQuad-associated local swelling AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000040 .

obo:UBERON_0003821 a rdfs:Class ;
  rdfs:label "metapodium bone" ;
  rdfs:comment "A bone of the metapodial skeleton" ;
  rdfs:subClassOf obo:UBERON_0001474 , obo:UBERON_0003606 , obo:UBERON_0012357 .

obo:VO_0000630 a rdfs:Class ;
  rdfs:label "licensed vaccine role" ;
  rdfs:comment "licensed vaccine role is a regulation-assigned role that indicates that a vaccine obtains official approval for commercial production and selling on the market." ;
  rdfs:subClassOf obo:VO_0000615 .

obo:NCBITaxon_10241 a rdfs:Class ;
  rdfs:label "Chordopoxvirinae" ;
  rdfs:subClassOf obo:NCBITaxon_10240 .

obo:OVAE_0000591 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated muscle pain AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an muscle pain AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000039 .

obo:UBERON_0000467 a rdfs:Class ;
  rdfs:label "anatomical system" ;
  rdfs:comment "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." ;
  rdfs:seeAlso obo:EHDAA2_0001330 ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OAE_0000368 a rdfs:Class ;
  rdfs:label "injection-site edema AE" ;
  rdfs:comment "an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found." ;
  rdfs:subClassOf obo:OAE_0000556 .

obo:OVAE_0000343 a rdfs:Class ;
  rdfs:label "Tripedia-associated drowsiness" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000049 .

obo:OVAE_0000757 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated malaise AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000051 .

obo:UBERON_0013522 a rdfs:Class ;
  rdfs:label "subdivision of tube" ;
  rdfs:subClassOf obo:UBERON_0000064 .

obo:UBERON_0035804 a rdfs:Class ;
  rdfs:label "future mouth" ;
  rdfs:comment "The primordial mouth region of the developing head." ;
  rdfs:subClassOf obo:UBERON_0002050 , obo:UBERON_0013522 .

obo:OVAE_0000583 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated increased sleep AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an increased sleep AE" ;
  rdfs:subClassOf obo:OAE_0001558 , obo:OVAE_0000039 .

obo:OVAE_0000111 a rdfs:Class ;
  rdfs:label "Hepatitis B virus vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Hepatitis B virus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:UBERON_0005178 a rdfs:Class ;
  rdfs:label "thoracic cavity element" ;
  rdfs:comment "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli." ;
  rdfs:subClassOf obo:UBERON_0000062 , obo:UBERON_0005181 .

obo:OVAE_0000710 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated injection-site edema AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0000368 , obo:OVAE_0000048 .

obo:UBERON_0009564 a rdfs:Class ;
  rdfs:label "distal limb integumentary appendage" ;
  rdfs:comment "A nail, hoof or claw." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0013703 .

obo:OVAE_0000317 a rdfs:Class ;
  rdfs:label "Biothrax-associated injection-site pain AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000061 .

obo:OAE_0000770 a rdfs:Class ;
  rdfs:label "bronchospasm AE" ;
  rdfs:comment "a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles" ;
  rdfs:subClassOf obo:OAE_0000434 .

obo:OAE_0000373 a rdfs:Class ;
  rdfs:label "pruritus AE" ;
  rdfs:comment "a skin adverse event that has an outcome of pruritus" ;
  rdfs:subClassOf obo:OAE_0000543 .

obo:OAE_0000388 a rdfs:Class ;
  rdfs:label "dizziness AE" ;
  rdfs:comment "a sensory capability AE that has an outcome of dizziness" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:VO_0000812 a rdfs:Class ;
  rdfs:label "USA licensed vaccine role" ;
  rdfs:comment "a licensed vaccine role that indicates the vaccine occurs in USA." ;
  rdfs:subClassOf obo:VO_0000630 .

obo:UBERON_0034929 a rdfs:Class ;
  rdfs:label "external soft tissue zone" ;
  rdfs:comment "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:OBI_0600007 a rdfs:Class ;
  rdfs:label "administering substance in vivo"@en ;
  rdfs:comment "A process by which a substance is intentionally given to an organism resulting in exposure of the organism to that substance." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OVAE_0000104 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:OVAE_0000776 a rdfs:Class ;
  rdfs:label "Zostavax-associated headache AE" ;
  rdfs:comment "A Zostavax vaccine adverse event that is associated with an administration of Zostavax and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000056 .

obo:OVAE_0000458 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated injection-site erythema AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000042 .

obo:OBI_0100026 a rdfs:Class ;
  rdfs:label "organism"@en ;
  rdfs:comment "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:VO_0000207 a rdfs:Class ;
  rdfs:label "vaccine contraindication" ;
  rdfs:comment "A vaccine contraindication is a contraindication that increases the risks of a vaccination. " ;
  rdfs:subClassOf obo:OAE_0000055 .

obo:NCBITaxon_11270 a rdfs:Class ;
  rdfs:label "Rhabdoviridae" ;
  rdfs:subClassOf obo:NCBITaxon_11157 .

obo:OVAE_0000754 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated injection-site pain AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000051 .

obo:OVAE_0000690 a rdfs:Class ;
  rdfs:label "Tenivac-associated injection-site redness AE" ;
  rdfs:comment "A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000045 .

obo:UBERON_0012357 a rdfs:Class ;
  rdfs:label "digitopodium bone" ;
  rdfs:comment "A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton." ;
  rdfs:subClassOf obo:UBERON_0001474 , obo:UBERON_0011250 .

obo:OAE_0000350 a rdfs:Class ;
  rdfs:label "rhinitis AE" ;
  rdfs:comment "rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose" ;
  rdfs:subClassOf obo:OAE_0000564 .

obo:UBERON_0012275 a rdfs:Class ;
  rdfs:label "meso-epithelium" ;
  rdfs:comment "Epithelium that derives from the mesoderm. [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0000483 , obo:UBERON_0004120 .

obo:UBERON_0013514 a rdfs:Class ;
  rdfs:label "space surrounding organism" ;
  rdfs:comment "The space that surrounds an organism." ;
  rdfs:subClassOf obo:UBERON_0000464 .

obo:UBERON_0002328 a rdfs:Class ;
  rdfs:label "notochord" ;
  rdfs:comment "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." ;
  rdfs:subClassOf obo:UBERON_0000481 , obo:UBERON_0004120 , obo:UBERON_0004121 .

obo:BSPO_0000102 a rdf:Property ;
  rdfs:label "ventral_to" ;
  rdfs:comment "x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly)." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BSPO_0000098 a rdf:Property ;
  rdfs:label "dorsal_to" ;
  rdfs:comment "x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly)." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:UBERON_0002472 a rdfs:Class ;
  rdfs:label "stylopod" ;
  rdfs:comment "The proximal free limb segment. Includes as parts the stylopod skeleton." ;
  rdfs:subClassOf obo:UBERON_0002529 .

obo:OVAE_0000292 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated injection-site redness AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000011 .

obo:UBERON_0013686 a rdfs:Class ;
  rdfs:label "anatomical conduit space" ;
  rdfs:comment "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]." ;
  rdfs:subClassOf obo:UBERON_0000464 .

obo:OVAE_0000561 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated fatigue AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000031 .

obo:OVAE_0000640 a rdfs:Class ;
  rdfs:label "Meruvax II-associated fever AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000033 .

obo:UBERON_0004121 a rdfs:Class ;
  rdfs:label "ectoderm-derived structure" ;
  rdfs:comment "An anatomical structure that develops (entirely or partially) from the ectoderm." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0002048 a rdfs:Class ;
  rdfs:label "lung" ;
  rdfs:comment "Respiration organ that develops as an oupocketing of the esophagus." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/701> ;
  rdfs:subClassOf obo:UBERON_0000171 , obo:UBERON_0004119 , obo:UBERON_0005178 , obo:UBERON_0015212 .

obo:OVAE_0000526 a rdfs:Class ;
  rdfs:label "MenHibrix-associated injection-site redness AE" ;
  rdfs:comment "A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000030 .

obo:OVAE_0000339 a rdfs:Class ;
  rdfs:label "Tripedia-associated injection-site pain AE" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000049 .

obo:NCBITaxon_10880 a rdfs:Class ;
  rdfs:label "Reoviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35325 .

obo:UBERON_0010285 a rdfs:Class ;
  rdfs:label "midbrain basal plate" ;
  rdfs:comment "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." ;
  rdfs:subClassOf obo:UBERON_0002020 .

obo:UBERON_0005497 a rdfs:Class ;
  rdfs:label "non-neural ectoderm" ;
  rdfs:comment "Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). Editor note: todo - epidermis? todo - track down EHDAA2 class in new release" ;
  rdfs:subClassOf obo:UBERON_0000479 , obo:UBERON_0004121 .

obo:OVAE_0000612 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated muscle ache AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an muscle ache AE" ;
  rdfs:subClassOf obo:OAE_0000383 , obo:OVAE_0000022 .

obo:OVAE_0000706 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated nausea AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000047 .

obo:OAE_0001546 a rdfs:Class ;
  rdfs:label "injection-site redness AE"@en ;
  rdfs:comment "an injection-site AE that display an redness in the injection-site" ;
  rdfs:subClassOf obo:OAE_0000366 .

obo:UBERON_0034874 a rdfs:Class ;
  rdfs:label "air in respiratory system" ;
  rdfs:comment "Any portion of gas located in a part of the respiratory system that is composed primarily of air." ;
  rdfs:subClassOf obo:UBERON_0034947 .

obo:NCBITaxon_11051 a rdfs:Class ;
  rdfs:label "Flavivirus" ;
  rdfs:subClassOf obo:NCBITaxon_11050 .

obo:UBERON_0007284 a rdfs:Class ;
  rdfs:label "presumptive neural plate" ;
  rdfs:comment "A presumptive structure that has the potential to develop into a neural plate." ;
  rdfs:subClassOf obo:UBERON_0006598 , obo:UBERON_0016879 .

obo:OVAE_0000515 a rdfs:Class ;
  rdfs:label "Menveo-associated irritability AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000032 .

obo:OVAE_0000455 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated injection-site pain AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000042 .

obo:NCBITaxon_11071 a rdfs:Class ;
  rdfs:label "Japanese encephalitis virus group" ;
  rdfs:subClassOf obo:NCBITaxon_11051 .

obo:PATO_0002146 a rdfs:Class ;
  rdfs:label "virulence"@en ;
  rdfs:comment "A quality inhering in a bearer by virtue of the bearer's pathogenicity."@en ;
  rdfs:subClassOf obo:PATO_0001995 .

obo:OVAE_0000394 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated local swelling AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000035 .

obo:VO_0000179 a rdfs:Class ;
  rdfs:label "vaccine component" ;
  rdfs:comment "a processed material that is output of the vaccine preparation and part of a vaccine." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0006595 a rdfs:Class ;
  rdfs:label "presumptive endoderm" ;
  rdfs:comment "Presumptive structure of the blastula that will develop into endoderm." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:VO_0000737 a rdfs:Class ;
  rdfs:label "Measles-Mumps-Rubella-Vericella vaccine" ;
  rdfs:comment "A Measles-Mumps-Rubella vaccine that also protects against Vericella. " ;
  rdfs:subClassOf obo:VO_0000731 .

obo:OVAE_0000346 a rdfs:Class ;
  rdfs:label "Infanrix-associated injection-site redness AE" ;
  rdfs:comment "A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000023 .

obo:VO_0000667 a rdfs:Class ;
  rdfs:label "human papillomavirus vaccine" ;
  rdfs:comment "a vaccine against human papillomavirus infection" ;
  rdfs:subClassOf obo:VO_0000748 .

obo:OVAE_0000430 a rdfs:Class ;
  rdfs:label "Havrix-associated irritability AE" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000020 .

obo:VO_0000512 a rdfs:Class ;
  rdfs:label "Pox vaccine"@en ;
  rdfs:comment "a viral vaccine against a disease caused by a virus belong to Poxviridae. " ;
  rdfs:subClassOf obo:VO_0000609 .

obo:UBERON_0005725 a rdfs:Class ;
  rdfs:label "olfactory system" ;
  rdfs:comment "A sensory system that is capable of olfacttion (the sensory perception of smell)." ;
  rdfs:subClassOf obo:UBERON_0005726 .

obo:UBERON_0010713 a rdfs:Class ;
  rdfs:label "paired fin skeleton" ;
  rdfs:comment "The collection of all skeletal elements in a single paired fin." ;
  rdfs:subClassOf obo:UBERON_0010912 , obo:UBERON_0011582 , obo:UBERON_0012353 .

obo:UBERON_0000486 a rdfs:Class ;
  rdfs:label "multilaminar epithelium" ;
  rdfs:comment "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0000483 .

obo:PATO_0001236 a rdfs:Class ;
  rdfs:label "process quality" ;
  rdfs:comment "A quality which inheres in an process." ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:UBERON_0000171 a rdfs:Class ;
  rdfs:label "respiration organ" ;
  rdfs:comment "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OVAE_0000469 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated pharyngitis AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an pharyngitis AE" ;
  rdfs:subClassOf obo:OAE_0000343 , obo:OVAE_0000042 .

obo:UBERON_0010546 a rdfs:Class ;
  rdfs:label "metapodial skeleton" ;
  rdfs:comment "Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

obo:OVAE_0000108 a rdfs:Class ;
  rdfs:label "Haemophilus b and Hepatitis B vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Haemophilus b and Hepatitis B vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:NCBITaxon_11157 a rdfs:Class ;
  rdfs:label "Mononegavirales" ;
  rdfs:subClassOf obo:NCBITaxon_35301 .

obo:UBERON_0003081 a rdfs:Class ;
  rdfs:label "lateral plate mesoderm" ;
  rdfs:comment "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005291 , obo:UBERON_0007524 .

obo:OVAE_0000014 a rdfs:Class ;
  rdfs:label "FluMist Quadrivalent vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of FluMist Quadrivalent vaccine." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:OVAE_0000596 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated rash AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000039 .

obo:UBERON_0005881 a rdfs:Class ;
  rdfs:label "autopodial extension" ;
  rdfs:comment "A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:OVAE_0000749 a rdfs:Class ;
  rdfs:label "Vivotif-associated fever AE" ;
  rdfs:comment "A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000054 .

obo:VO_0000742 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus vaccine" ;
  rdfs:subClassOf obo:VO_0000943 .

obo:UBERON_0009615 a rdfs:Class ;
  rdfs:label "midbrain hindbrain boundary neural plate" ;
  rdfs:subClassOf obo:UBERON_0000015 .

obo:CARO_0001008 a rdfs:Class ;
  rdfs:label "gross anatomical part"@en ;
  rdfs:comment "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell.  Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OVAE_0000054 a rdfs:Class ;
  rdfs:label "Vivotif vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000107 .

obo:OVAE_0000324 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site redness AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000007 .

obo:BFO_0000019 a rdfs:Class ;
  rdfs:label "quality"@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:OVAE_0000729 a rdfs:Class ;
  rdfs:label "Adacel-associated fatigue AE" ;
  rdfs:comment "A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000988 .

obo:UBERON_0001896 a rdfs:Class ;
  rdfs:label "medulla oblongata" ;
  rdfs:comment "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." ;
  rdfs:subClassOf obo:UBERON_0000064 , obo:UBERON_0004121 , obo:UBERON_0010314 .

obo:VO_0000969 a rdfs:Class ;
  rdfs:label "nkCMVint DNA vaccine plasmid"@en ;
  rdfs:comment "A DNA vaccine plasmid vector that has the plasmid label nkCMVint." ;
  rdfs:subClassOf obo:VO_0000435 .

obo:VO_0001479 a rdfs:Class ;
  rdfs:label "vaccine target specification" ;
  rdfs:comment "The objective that intends to produce vaccine via the vaccine preparation process." ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OVAE_0000452 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated decreased appetite AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000042 .

obo:UBERON_0011822 a rdfs:Class ;
  rdfs:label "dense irregular connective tissue" ;
  rdfs:comment "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium." ;
  rdfs:subClassOf obo:UBERON_0011821 , obo:UBERON_0011823 .

obo:OAE_0000326 a rdfs:Class ;
  rdfs:label "injection-site warmth AE" ;
  rdfs:comment "injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site" ;
  rdfs:subClassOf obo:OAE_0000555 .

obo:OVAE_0000550 a rdfs:Class ;
  rdfs:label "Menactra-associated fatigue AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000029 .

obo:VO_0001254 a rdfs:Class ;
  rdfs:label "capsular polysaccharide of pathogen organism as vaccine component" ;
  rdfs:subClassOf obo:VO_0001256 .

obo:OVAE_0000466 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated malaise AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000042 .

obo:UBERON_0005866 a rdfs:Class ;
  rdfs:label "pre-cartilage condensation" ;
  rdfs:comment "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." ;
  rdfs:subClassOf obo:UBERON_0005291 , obo:UBERON_0005856 , obo:UBERON_0006598 .

obo:OAE_0000377 a rdfs:Class ;
  rdfs:label "headache AE" ;
  rdfs:comment "a pain AE that has an outcome of headache" ;
  rdfs:subClassOf obo:OAE_0000374 .

obo:OVAE_0000234 a rdfs:Class ;
  rdfs:label "Fluarix-associated injection-site pain AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000010 .

obo:OVAE_0000313 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated abdominal pain AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an abdominal pain AE" ;
  rdfs:subClassOf obo:OAE_0000402 , obo:OVAE_0000074 .

obo:OVAE_0000667 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated convulsion AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an convulsion AE" ;
  rdfs:subClassOf obo:OAE_0000306 , obo:OVAE_0000046 .

obo:NCBITaxon_11292 a rdfs:Class ;
  rdfs:label "Rabies virus" ;
  rdfs:subClassOf obo:NCBITaxon_11270 .

obo:VO_0000194 a rdfs:Class ;
  rdfs:label "USA licensed human vaccine role"@en ;
  rdfs:comment "a USA licensed vaccine role that inheres ina vaccine approven to be by the US FDA to be used for humans in the USA. " ;
  rdfs:subClassOf obo:VO_0000489 , obo:VO_0000812 .

obo:BFO_0000035 a rdfs:Class ;
  rdfs:label "process boundary"@en ;
  rdfs:comment "p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:OVAE_0000774 a rdfs:Class ;
  rdfs:label "YF-Vax-associated injection-site pain AE" ;
  rdfs:comment "A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000055 .

obo:OAE_0000323 a rdfs:Class ;
  rdfs:label "injection-site induration AE" ;
  rdfs:comment "injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site" ;
  rdfs:subClassOf obo:OAE_0000543 .

obo:OAE_0001555 a rdfs:Class ;
  rdfs:label "induration with tenderness AE"@en ;
  rdfs:comment "a sensory capability AE that results in a sensation of induration with tenderness." ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:UBERON_0002481 a rdfs:Class ;
  rdfs:label "bone tissue" ;
  rdfs:comment "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." ;
  rdfs:subClassOf obo:UBERON_0004755 .

obo:UBERON_0005732 a rdfs:Class ;
  rdfs:label "paired limb/fin field" ;
  rdfs:comment "A ring of cells capable of forming a limb or paired fin[Gilbert,modified]." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005291 , obo:UBERON_0007688 .

obo:OVAE_0000522 a rdfs:Class ;
  rdfs:label "Menveo-associated myalgia AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000032 .

obo:UBERON_0007377 a rdfs:Class ;
  rdfs:label "stratum compactum" ;
  rdfs:comment "Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0004121 , obo:UBERON_0013754 .

obo:OVAE_0000349 a rdfs:Class ;
  rdfs:label "Infanrix-associated drowsiness" ;
  rdfs:comment "A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000023 .

obo:OVAE_0000414 a rdfs:Class ;
  rdfs:label "Comvax-associated vomiting AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000065 .

obo:VO_0000045 a rdfs:Class ;
  rdfs:label "Fluarix" ;
  rdfs:comment "Trade Name: Fluarix" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:OAE_0001837 a rdfs:Class ;
  rdfs:label "AE severity G2"@en ;
  rdfs:comment "a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances)." ;
  rdfs:subClassOf obo:OAE_0001750 .

obo:OVAE_0000411 a rdfs:Class ;
  rdfs:label "Comvax-associated fever AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000065 .

obo:UBERON_0004734 a rdfs:Class ;
  rdfs:label "gastrula" ;
  rdfs:comment "Organism at the gastrula stage." ;
  rdfs:subClassOf obo:UBERON_0000468 , obo:UBERON_0000922 .

obo:OVAE_0000340 a rdfs:Class ;
  rdfs:label "Tripedia-associated fever AE" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000049 .

obo:UBERON_0004016 a rdfs:Class ;
  rdfs:label "dermatome" ;
  rdfs:comment "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." ;
  rdfs:subClassOf obo:UBERON_0017650 .

obo:UBERON_0006562 a rdfs:Class ;
  rdfs:label "pharynx" ;
  rdfs:comment "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." ;
  rdfs:subClassOf obo:UBERON_0004921 .

obo:UBERON_0001015 a rdfs:Class ;
  rdfs:label "musculature" ;
  rdfs:comment "A subdivision of the muscular system corresponding to a subdisivision of an organism." ;
  rdfs:subClassOf obo:UBERON_0011216 .

obo:OVAE_0000724 a rdfs:Class ;
  rdfs:label "Adacel-associated injection-site pain AE" ;
  rdfs:comment "A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000988 .

obo:OVAE_0000565 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated injection-site pain AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000037 .

obo:OAE_0000574 a rdfs:Class ;
  rdfs:label "gustatory system AE" ;
  rdfs:comment "an adverse event that occurs in a gustatory system"@en ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:VO_0012185 a rdfs:Class ;
  rdfs:label "Haemophilus influenzae vaccine" ;
  rdfs:comment "A vaccine that protects against Haemophilus influenzae." ;
  rdfs:subClassOf obo:VO_0000661 .

obo:OVAE_0000684 a rdfs:Class ;
  rdfs:label "Decavac-associated chills AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an chills AE" ;
  rdfs:subClassOf obo:OAE_0000394 , obo:OVAE_0000067 .

obo:OVAE_0000350 a rdfs:Class ;
  rdfs:label "Infanrix-associated irritability AE" ;
  rdfs:comment "A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000023 .

obo:OVAE_0000429 a rdfs:Class ;
  rdfs:label "Havrix-associated injection-site redness AE" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000020 .

obo:UBERON_0001891 a rdfs:Class ;
  rdfs:label "midbrain" ;
  rdfs:comment "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." ;
  rdfs:subClassOf obo:UBERON_0002616 , obo:UBERON_0010314 .

obo:UBERON_0002036 a rdfs:Class ;
  rdfs:label "striated muscle tissue" ;
  rdfs:comment "Muscle tissue that contains fibers that are divided by transverse bands into striations." ;
  rdfs:subClassOf obo:UBERON_0002385 .

obo:OVAE_0000507 a rdfs:Class ;
  rdfs:label "ProQuad-associated injection-site muscular soreness AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site muscular soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000040 .

obo:OVAE_0000689 a rdfs:Class ;
  rdfs:label "Tenivac-associated headache AE" ;
  rdfs:comment "A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000045 .

obo:OVAE_0000732 a rdfs:Class ;
  rdfs:label "Boostrix-associated injection-site pain AE" ;
  rdfs:comment "A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000063 .

obo:OVAE_0000484 a rdfs:Class ;
  rdfs:label "Cervarix-associated headache AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000064 .

obo:OVAE_0000665 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated dizziness AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an dizziness AE" ;
  rdfs:subClassOf obo:OAE_0000388 , obo:OVAE_0000046 .

obo:CHEBI_52071 a rdfs:Class ;
  rdfs:label "dextran" ;
  rdfs:comment "A (1->6)-alpha-D-glucan which has extra branching consisting of (1->2), (1->3) or (1->4) linkages." ;
  rdfs:subClassOf obo:CHEBI_23367 .

obo:OVAE_0000735 a rdfs:Class ;
  rdfs:label "Boostrix-associated injection-site edema AE" ;
  rdfs:comment "A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site edema AE" ;
  rdfs:subClassOf obo:OAE_0001553 , obo:OVAE_0000063 .

obo:OVAE_0000511 a rdfs:Class ;
  rdfs:label "ProQuad-associated irritability AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000040 .

obo:OVAE_0000678 a rdfs:Class ;
  rdfs:label "Decavac-associated local swelling AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000067 .

obo:OVAE_0000019 a rdfs:Class ;
  rdfs:label "Gardasil vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000075 .

obo:UBERON_0017650 a rdfs:Class ;
  rdfs:label "developing mesenchymal structure" ;
  rdfs:comment "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:UBERON_0012353 a rdfs:Class ;
  rdfs:label "fin skeleton" ;
  rdfs:comment "Skeletal subdivision consisting of all the skeletal elements in a single fin." ;
  rdfs:subClassOf obo:UBERON_0010912 .

obo:OVAE_0000361 a rdfs:Class ;
  rdfs:label "Pediarix-associated local swelling AE" ;
  rdfs:comment "A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000034 .

obo:UBERON_0003059 a rdfs:Class ;
  rdfs:label "presomitic mesoderm" ;
  rdfs:comment "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." ;
  rdfs:subClassOf obo:UBERON_0005423 , obo:UBERON_0006598 .

obo:UBERON_0000067 a rdfs:Class ;
  rdfs:label "embryo stage part" ;
  rdfs:comment "A stage that is part of the embryo stage." ;
  rdfs:subClassOf obo:UBERON_0000105 .

obo:OAE_0000200 a rdfs:Class ;
  rdfs:label "hair AE" ;
  rdfs:comment "a hair, skin, and nail AE that occurs in hair." ;
  rdfs:subClassOf obo:OAE_0000199 .

obo:OVAE_0000302 a rdfs:Class ;
  rdfs:label "Influenza Virus Vaccine H5N1-associated injection-site pain AE" ;
  rdfs:comment "A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000024 .

obo:OVAE_0000321 a rdfs:Class ;
  rdfs:label "Biothrax-associated muscle ache AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an muscle ache AE" ;
  rdfs:subClassOf obo:OAE_0000383 , obo:OVAE_0000061 .

obo:OVAE_0000559 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated injection-site induration AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000031 .

obo:OVAE_0000400 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated crying abnormal AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an crying abnormal AE" ;
  rdfs:subClassOf obo:OAE_0000393 , obo:OVAE_0000035 .

obo:OVAE_0000473 a rdfs:Class ;
  rdfs:label "Gardasil-associated nausea AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000019 .

obo:OAE_0000402 a rdfs:Class ;
  rdfs:label "abdominal pain AE" ;
  rdfs:comment "a pain AE that is observed in abdominal cavity" ;
  rdfs:subClassOf obo:OAE_0000374 .

obo:UBERON_0003076 a rdfs:Class ;
  rdfs:label "posterior neural tube" ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:UBERON_0002090 a rdfs:Class ;
  rdfs:label "postcranial axial skeleton" ;
  rdfs:comment "The post-cranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]." ;
  rdfs:seeAlso <http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton> ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010912 .

obo:NCBITaxon_724 a rdfs:Class ;
  rdfs:label "Haemophilus" ;
  rdfs:subClassOf obo:NCBITaxon_712 .

obo:NCBITaxon_2759 a rdfs:Class ;
  rdfs:label "Eukaryota" ;
  rdfs:subClassOf obo:OBI_0100026 .

obo:OVAE_0000010 a rdfs:Class ;
  rdfs:label "Fluarix vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Fluarix." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:VO_0000071 a rdfs:Class ;
  rdfs:label "Menactra" ;
  rdfs:comment "Product Name: Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine" ;
  rdfs:subClassOf obo:VO_0000053 .

obo:OVAE_0000592 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated joint pain AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an joint pain AE" ;
  rdfs:subClassOf obo:OAE_0001559 , obo:OVAE_0000039 .

obo:UBERON_0034922 a rdfs:Class ;
  rdfs:label "cell cluster" ;
  rdfs:comment "A cluster of cells, largely surrounded by a morphological boundary." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:OVAE_0000656 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated injection-site pain AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000046 .

obo:OVAE_0000050 a rdfs:Class ;
  rdfs:label "Twinrix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000110 .

obo:UBERON_0005062 a rdfs:Class ;
  rdfs:label "neural fold" ;
  rdfs:comment "One of the two elevated edges of the neural groove[GO,MP]." ;
  rdfs:subClassOf obo:UBERON_0005157 , obo:UBERON_0005291 , obo:UBERON_0010371 , obo:UBERON_0015212 .

obo:VO_0010738 a rdfs:Class ;
  rdfs:label "Rotarix" ;
  rdfs:comment "Trade Name: Rotarix" ;
  rdfs:subClassOf obo:VO_0000658 .

obo:OVAE_0000310 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated cough" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an cough" ;
  rdfs:subClassOf obo:OAE_0000398 , obo:OVAE_0000074 .

obo:UBERON_0002544 a rdfs:Class ;
  rdfs:label "digit" ;
  rdfs:comment "A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans)." ;
  rdfs:subClassOf obo:UBERON_0005881 .

obo:OVAE_0000554 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated drowsiness" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000031 .

obo:OVAE_0000216 a rdfs:Class ;
  rdfs:label "Agriflu-associated malaise AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000060 .

obo:NCBITaxon_151340 a rdfs:Class ;
  rdfs:label "Papillomaviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35237 .

obo:BFO_0000020 a rdfs:Class ;
  rdfs:label "specifically dependent continuant"@en ;
  rdfs:comment "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en ;
  rdfs:subClassOf obo:BFO_0000002 , obo:BFO_0000005 .

obo:OVAE_0000673 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated nausea AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000046 .

obo:OVAE_0000422 a rdfs:Class ;
  rdfs:label "Comvax-associated rash AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000065 .

obo:VO_0010727 a rdfs:Class ;
  rdfs:label "Menomune A/C/Y/W-135" ;
  rdfs:comment "Trade Name: Menomune A/C/Y/W-135" ;
  rdfs:subClassOf obo:VO_0000053 .

obo:OVAE_0000577 a rdfs:Class ;
  rdfs:label "Prevnar-associated injection-site tenderness AE" ;
  rdfs:comment "A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000038 .

obo:OVAE_0000101 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:OAE_0000581 a rdfs:Class ;
  rdfs:label "movement disorder AE" ;
  rdfs:comment "a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements"@en ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:UBERON_0000481 a rdfs:Class ;
  rdfs:label "multi-tissue structure" ;
  rdfs:comment "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:UBERON_0034706 a rdfs:Class ;
  rdfs:label "proliferating neuroepithelium" ;
  rdfs:comment "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." ;
  rdfs:subClassOf obo:UBERON_0034705 .

obo:UBERON_0010096 a rdfs:Class ;
  rdfs:label "future myelencephalon" ;
  rdfs:comment "A developing anatomical structure that has the potential to develop into a myelencephalon." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:VO_0000096 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral" ;
  rdfs:subClassOf obo:VO_0000037 .

obo:NCBITaxon_28216 a rdfs:Class ;
  rdfs:label "Betaproteobacteria" ;
  rdfs:subClassOf obo:NCBITaxon_1224 .

obo:VO_0000931 a rdfs:Class ;
  rdfs:label "vaccine residual protein from cell culture" ;
  rdfs:comment "a cell culture residual in vaccine that is residual protein from cell culture. " ;
  rdfs:subClassOf obo:VO_0000856 .

obo:OVAE_0000278 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated malaise AE" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000018 .

obo:UBERON_0034969 a rdfs:Class ;
  rdfs:label "epithelial layer of duct" ;
  rdfs:subClassOf obo:UBERON_0000483 , obo:UBERON_0003914 .

obo:UBERON_0008947 a rdfs:Class ;
  rdfs:label "respiratory primordium" ;
  rdfs:subClassOf obo:UBERON_0001048 .

obo:VO_0000545 a rdfs:Class ;
  rdfs:label "human vaccinee population" ;
  rdfs:comment "a population of human beings who are vaccinated." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0007794 a rdfs:Class ;
  rdfs:label "serous fluid" ;
  rdfs:comment "Any fluid produced by a serous gland." ;
  rdfs:subClassOf obo:UBERON_0000456 , obo:UBERON_0006314 .

obo:OVAE_0000717 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated pain AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an pain AE" ;
  rdfs:subClassOf obo:OAE_0000374 , obo:OVAE_0000048 .

obo:NCBITaxon_80840 a rdfs:Class ;
  rdfs:label "Burkholderiales" ;
  rdfs:subClassOf obo:NCBITaxon_28216 .

obo:UBERON_0001981 a rdfs:Class ;
  rdfs:label "blood vessel" ;
  rdfs:comment "A vessel through which blood circulates in the body." ;
  rdfs:subClassOf obo:UBERON_0000055 , obo:UBERON_0004120 .

obo:UBERON_0011858 a rdfs:Class ;
  rdfs:label "acinus of exocrine gland" ;
  rdfs:comment "An acinus that is part of a exocrine gland." ;
  rdfs:subClassOf obo:UBERON_0009842 .

obo:UBERON_0001004 a rdfs:Class ;
  rdfs:label "respiratory system" ;
  rdfs:comment "Functional system which consists of structures involved in respiration." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OVAE_0000213 a rdfs:Class ;
  rdfs:label "Agriflu-associated injection-site pain AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000060 .

obo:NCBITaxon_197911 a rdfs:Class ;
  rdfs:label "Influenzavirus A" ;
  rdfs:subClassOf obo:NCBITaxon_11308 .

obo:VO_0000732 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus vaccine" ;
  rdfs:comment "A Corynebacterium diphtheriae vaccine that also protect against infection with Clostridium tetani." ;
  rdfs:subClassOf obo:VO_0000735 .

obo:UBERON_0010707 a rdfs:Class ;
  rdfs:label "appendage girdle complex" ;
  rdfs:comment "An organism subdivision that includes both an appendage and its accociated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." ;
  rdfs:subClassOf obo:UBERON_0000475 , obo:UBERON_0015212 .

obo:OVAE_0000495 a rdfs:Class ;
  rdfs:label "JE-Vax-associated fever AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000027 .

obo:OVAE_0000531 a rdfs:Class ;
  rdfs:label "MenHibrix-associated fever AE" ;
  rdfs:comment "A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000030 .

obo:UBERON_0016887 a rdfs:Class ;
  rdfs:label "entire extraembryonic component" ;
  rdfs:comment "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:UBERON_0002204 a rdfs:Class ;
  rdfs:label "musculoskeletal system" ;
  rdfs:comment "Anatomical system that consists of the muscular and skeletal systems." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OBI_0000245 a rdfs:Class ;
  rdfs:label "organization"@en ;
  rdfs:comment "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OVAE_0000576 a rdfs:Class ;
  rdfs:label "Prevnar-associated injection-site induration AE" ;
  rdfs:comment "A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000038 .

obo:NCBITaxon_89593 a rdfs:Class ;
  rdfs:label "Craniata <chordata>" ;
  rdfs:subClassOf obo:NCBITaxon_33213 .

obo:UBERON_0007100 a rdfs:Class ;
  rdfs:label "primary circulatory organ" ;
  rdfs:comment "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]." ;
  rdfs:subClassOf obo:UBERON_0015228 .

obo:OVAE_0000306 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated upper respiratory tract infection AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an upper respiratory tract infection AE" ;
  rdfs:subClassOf obo:OAE_0000358 , obo:OVAE_0000074 .

obo:NCBITaxon_11320 a rdfs:Class ;
  rdfs:label "Influenza A virus" ;
  rdfs:subClassOf obo:NCBITaxon_197911 .

obo:OVAE_0000590 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated headache AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000039 .

obo:VO_0001374 a rdfs:Class ;
  rdfs:label "vaccinee" ;
  rdfs:comment "an organism that is vaccinated with a vaccine" ;
  rdfs:subClassOf obo:OBI_0100026 .

obo:OAE_0000217 a rdfs:Class ;
  rdfs:label "prolonged crying AE"@en ;
  rdfs:comment "a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient" ;
  rdfs:subClassOf obo:OAE_0000393 .

obo:VO_0000030 a rdfs:Class ;
  rdfs:label "DECAVAC" ;
  rdfs:comment "Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use" ;
  rdfs:subClassOf obo:VO_0000732 .

obo:UBERON_0007798 a rdfs:Class ;
  rdfs:label "vascular system" ;
  rdfs:comment "Anatomical system that consists of all blood and lymph vessels." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:UBERON_0011249 a rdfs:Class ;
  rdfs:label "appendicular skeletal system" ;
  rdfs:comment "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton> ;
  rdfs:subClassOf obo:UBERON_0000075 .

obo:OAE_0001547 a rdfs:Class ;
  rdfs:label "injection-site tenderness AE"@en ;
  rdfs:comment "a sensory capability AE that shows up skin tenderness and occurs in an injection site of a medical intervention" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:UBERON_0034947 a rdfs:Class ;
  rdfs:label "gas in respiratory system" ;
  rdfs:comment "Any portion of gas located in a part of the respiratory system." ;
  rdfs:subClassOf obo:UBERON_0034873 .

obo:VO_0000082 a rdfs:Class ;
  rdfs:label "Pediarix" ;
  rdfs:comment "Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined" ;
  rdfs:subClassOf obo:VO_0000743 .

obo:OVAE_0000751 a rdfs:Class ;
  rdfs:label "Vivotif-associated vomiting AE" ;
  rdfs:comment "A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000054 .

obo:OVAE_0000503 a rdfs:Class ;
  rdfs:label "JE-Vax-associated vomiting AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000027 .

obo:VO_0001244 a rdfs:Class ;
  rdfs:label "Prevnar 13" ;
  rdfs:subClassOf obo:VO_0000424 .

obo:OVAE_0000566 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated injection-site muscular soreness AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site muscular soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000037 .

obo:UBERON_0000066 a rdfs:Class ;
  rdfs:label "fully formed stage" ;
  rdfs:comment "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/566> ;
  rdfs:subClassOf obo:UBERON_0000105 .

obo:OAE_0000362 a rdfs:Class ;
  rdfs:label "rash AE" ;
  rdfs:comment "a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful." ;
  rdfs:subClassOf obo:OAE_0000543 .

obo:OAE_0000358 a rdfs:Class ;
  rdfs:label "upper respiratory tract infection AE" ;
  rdfs:comment "an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx" ;
  rdfs:subClassOf obo:OAE_0000363 .

obo:UBERON_0005174 a rdfs:Class ;
  rdfs:label "dorsal region element" ;
  rdfs:comment "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:UBERON_0015410 a rdfs:Class ;
  rdfs:label "heart plus pericardium" ;
  rdfs:subClassOf obo:UBERON_0005178 .

obo:OVAE_0000520 a rdfs:Class ;
  rdfs:label "Menveo-associated injection-site pain AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000032 .

obo:OVAE_0000008 a rdfs:Class ;
  rdfs:label "Engerix-B vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000111 .

obo:OVAE_0000224 a rdfs:Class ;
  rdfs:label "Fluarix-associated irritability AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000010 .

obo:OAE_0000378 a rdfs:Class ;
  rdfs:label "respiratory system AE" ;
  rdfs:comment "an AE that occurs in respiratory system." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:VO_0000121 a rdfs:Class ;
  rdfs:label "YF-Vax" ;
  rdfs:comment "Product Name: Yellow Fever Vaccine" ;
  rdfs:subClassOf obo:VO_0000123 .

obo:VO_0000980 a rdfs:Class ;
  rdfs:label "Flucelvax"@en ;
  rdfs:comment "Trade Name: Flucelvax" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:OVAE_0000645 a rdfs:Class ;
  rdfs:label "Meruvax II-associated irritability AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000033 .

obo:OVAE_0000634 a rdfs:Class ;
  rdfs:label "RotaTeq-associated diarrhea AE" ;
  rdfs:comment "A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000044 .

obo:VO_0003021 a rdfs:Class ;
  rdfs:label "oral vaccination" ;
  rdfs:comment "vaccination process that occurs in oral route." ;
  rdfs:subClassOf obo:VO_0000002 .

obo:OVAE_0000555 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated irritability AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000031 .

obo:UBERON_0003929 a rdfs:Class ;
  rdfs:label "digestive tract epithelium" ;
  rdfs:comment "An epithelium that lines the lumen of the digestive tract." ;
  rdfs:subClassOf obo:UBERON_0000483 .

obo:OVAE_0000205 a rdfs:Class ;
  rdfs:label "Afluria-associated myalgia AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000984 .

obo:VO_0001139 a rdfs:Class ;
  rdfs:label "vaccine organism viability" ;
  rdfs:comment "vaccine viability is a viability of a vaccine organism." ;
  rdfs:subClassOf obo:PATO_0000169 .

obo:OVAE_0000650 a rdfs:Class ;
  rdfs:label "ACAM2000-associated lymphadenitis AE" ;
  rdfs:comment "A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an lymphadenitis AE" ;
  rdfs:subClassOf obo:OAE_0000331 , obo:OVAE_0000987 .

obo:UBERON_0004300 a rdfs:Class ;
  rdfs:label "distal phalanx" ;
  rdfs:comment "Distal-most phalanx within a digit." ;
  rdfs:subClassOf obo:UBERON_0003221 .

obo:UBERON_0002323 a rdfs:Class ;
  rdfs:label "coelemic cavity lumen" ;
  rdfs:comment "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." ;
  rdfs:subClassOf obo:UBERON_0002553 .

obo:RO_0002494 a rdf:Property ;
  rdfs:label "transformation of" ;
  rdfs:seeAlso <http://semanticscience.org/resource/SIO_000657> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002202 .

obo:OVAE_0000695 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated injection-site redness AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000047 .

obo:OVAE_0000064 a rdfs:Class ;
  rdfs:label "Cervarix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000075 .

obo:UBERON_0004290 a rdfs:Class ;
  rdfs:label "dermomyotome" ;
  rdfs:comment "The bilaminar epithelium formed from the myotome and dermatome." ;
  rdfs:subClassOf obo:UBERON_0000486 , obo:UBERON_0012275 , obo:UBERON_0016888 .

obo:OVAE_0000425 a rdfs:Class ;
  rdfs:label "Havrix-associated injection-site muscular soreness AE" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site muscular soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000020 .

obo:OAE_0000555 a rdfs:Class ;
  rdfs:label "homeostasis AE" ;
  rdfs:comment "an AE that occurs in the homeostasis system." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OVAE_0000024 a rdfs:Class ;
  rdfs:label "Influenza Virus Vaccine H5N1 vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Influenza virus vaccine H5N1 vaccine." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:VO_0001187 a rdfs:Class ;
  rdfs:label "intramuscular vaccination" ;
  rdfs:comment "a vaccination that occurs in the intramuscular route." ;
  rdfs:subClassOf obo:VO_0000002 .

obo:VO_0000004 a rdfs:Class ;
  rdfs:label "ActHIB" ;
  rdfs:comment "Product Name: Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)" ;
  rdfs:subClassOf obo:VO_0000662 .

obo:OVAE_0000444 a rdfs:Class ;
  rdfs:label "Twinrix-associated headache AE" ;
  rdfs:comment "A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000050 .

obo:OVAE_0000061 a rdfs:Class ;
  rdfs:label "Biothrax vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000076 .

obo:UBERON_0004537 a rdfs:Class ;
  rdfs:label "blood vasculature" ;
  rdfs:comment "A vascular network consisting of blood vessels." ;
  rdfs:subClassOf obo:UBERON_0002049 .

obo:OVAE_0000762 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated irritability AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000051 .

obo:UBERON_0005291 a rdfs:Class ;
  rdfs:label "embryonic tissue" ;
  rdfs:comment "A portion of tissue that is part of an embryo." ;
  rdfs:subClassOf obo:UBERON_0000479 , obo:UBERON_0002050 .

obo:OVAE_0000372 a rdfs:Class ;
  rdfs:label "Kinrix-associated decreased appetite AE" ;
  rdfs:comment "A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000028 .

obo:OVAE_0000661 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated local swelling AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000046 .

obo:UBERON_0002199 a rdfs:Class ;
  rdfs:label "integument" ;
  rdfs:comment "The dermis, epidermis and hypodermis." ;
  rdfs:subClassOf obo:UBERON_0003102 , obo:UBERON_0011216 .

obo:OVAE_0000202 a rdfs:Class ;
  rdfs:label "Afluria-associated injection-site redness AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000984 .

obo:VO_0000464 a rdfs:Class ;
  rdfs:label "protein of pathogen organism as vaccine component" ;
  rdfs:subClassOf obo:VO_0000000 .

obo:VO_0000920 a rdfs:Class ;
  rdfs:label "bovine albumin cell culture residual in vaccine" ;
  rdfs:comment "a cell culture residual in vaccine that is bovine albumin." ;
  rdfs:subClassOf obo:VO_0000856 .

obo:OVAE_0000713 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated urticaria AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an urticaria AE" ;
  rdfs:subClassOf obo:OAE_0000376 , obo:OVAE_0000048 .

obo:VO_0000768 a rdfs:Class ;
  rdfs:label "Salmonella vaccine" ;
  rdfs:comment "A bacterial vaccine that protects against infections by various Salmonella species." ;
  rdfs:subClassOf obo:VO_0000165 .

obo:OVAE_0000985 a rdfs:Class ;
  rdfs:label "FluMist vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of FluMist." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:UBERON_0001943 a rdfs:Class ;
  rdfs:label "midbrain tegmentum" ;
  rdfs:comment "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN10:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." ;
  rdfs:subClassOf obo:UBERON_0002616 .

obo:OGG_2000000002 a rdfs:Class ;
  rdfs:label "gene of Bacteria" ;
  rdfs:comment "A gene of an organism of Bacteria" ;
  rdfs:subClassOf obo:OGG_0000000002 .

obo:OAE_0000334 a rdfs:Class ;
  rdfs:label "musculoskeletal stiffness AE" ;
  rdfs:comment "a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:OAE_0000616 a rdfs:Class ;
  rdfs:label "diarrhea AE" ;
  rdfs:comment "an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel"@en ;
  rdfs:subClassOf obo:OAE_0000603 .

obo:OBI_0000444 a rdfs:Class ;
  rdfs:label "target of material addition role"@en ;
  rdfs:comment "target of material addition role is a role realized by an entity into which a material is added in a material addition process" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OVAE_0000329 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated urticaria AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an urticaria AE" ;
  rdfs:subClassOf obo:OAE_0000376 , obo:OVAE_0000007 .

obo:OVAE_0000403 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated rash AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000035 .

obo:OVAE_0000533 a rdfs:Class ;
  rdfs:label "Menactra-associated injection-site erythema AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000029 .

obo:UBERON_0007845 a rdfs:Class ;
  rdfs:label "regular connective tissue" ;
  rdfs:comment "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." ;
  rdfs:subClassOf obo:UBERON_0002384 .

obo:OVAE_0000021 a rdfs:Class ;
  rdfs:label "Hiberix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000072 .

obo:UBERON_0000924 a rdfs:Class ;
  rdfs:label "ectoderm" ;
  rdfs:comment "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." ;
  rdfs:subClassOf obo:UBERON_0000923 .

obo:OAE_0000390 a rdfs:Class ;
  rdfs:label "malaise AE" ;
  rdfs:comment "a sensory capability AE that has an outcome of malaise" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:UBERON_0000072 a rdfs:Class ;
  rdfs:label "proximo-distal subdivision of respiratory tract" ;
  rdfs:comment "An section of a respiratory tract." ;
  rdfs:subClassOf obo:UBERON_0004119 , obo:UBERON_0013522 .

obo:OVAE_0000078 a rdfs:Class ;
  rdfs:label "Streptococcus pneumoniae vaccine adverse event"@en ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:VO_0000092 a rdfs:Class ;
  rdfs:label "Fluzone intradermal"@en ;
  rdfs:comment "Trade Name: Fluzone intradermal" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:UBERON_0010912 a rdfs:Class ;
  rdfs:label "subdivision of skeleton" ;
  rdfs:comment "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." ;
  rdfs:subClassOf obo:UBERON_0011216 .

obo:VO_0000052 a rdfs:Class ;
  rdfs:label "Havrix" ;
  rdfs:comment "Product Name: Hepatitis A Vaccine, Inactivated" ;
  rdfs:subClassOf obo:VO_0000646 .

obo:UBERON_0000463 a rdfs:Class ;
  rdfs:label "organism substance" ;
  rdfs:comment "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OVAE_0000013 a rdfs:Class ;
  rdfs:label "Flulaval vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Flulaval." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:OVAE_0000281 a rdfs:Class ;
  rdfs:label "FluMist-associated sore throat AE" ;
  rdfs:comment "A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an sore throat AE" ;
  rdfs:subClassOf obo:OAE_0000538 , obo:OVAE_0000985 .

obo:UBERON_0009955 a rdfs:Class ;
  rdfs:label "neurogenic placode" ;
  rdfs:comment "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia." ;
  rdfs:subClassOf obo:UBERON_0002546 .

obo:OVAE_0000053 a rdfs:Class ;
  rdfs:label "Varivax vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000112 .

obo:OAE_0000643 a rdfs:Class ;
  rdfs:label "musculoskeletal pain AE" ;
  rdfs:comment "a pain AE that has an outcome of musculoskeletal pain" ;
  rdfs:subClassOf obo:OAE_0000374 .

obo:UBERON_0010371 a rdfs:Class ;
  rdfs:label "ecto-epithelium" ;
  rdfs:comment "Epithelium composed of cells that develops from the ectoderm[FMA,modified]." ;
  rdfs:subClassOf obo:UBERON_0000483 , obo:UBERON_0004121 .

obo:NCBITaxon_35301 a rdfs:Class ;
  rdfs:label "ssRNA negative-strand viruses" ;
  rdfs:subClassOf obo:NCBITaxon_439488 .

obo:OVAE_0000542 a rdfs:Class ;
  rdfs:label "Menactra-associated injection-site redness AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000029 .

obo:OVAE_0000508 a rdfs:Class ;
  rdfs:label "ProQuad-associated injection-site erythema AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000040 .

obo:UBERON_0011582 a rdfs:Class ;
  rdfs:label "paired limb/fin skeleton" ;
  rdfs:comment "The collection of all skeletal elements in an individual limb or fin." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010912 .

obo:OVAE_0000067 a rdfs:Class ;
  rdfs:label "Decavac vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000101 .

obo:OVAE_0000472 a rdfs:Class ;
  rdfs:label "Gardasil-associated fever AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000019 .

obo:OVAE_0000353 a rdfs:Class ;
  rdfs:label "Daptacel-associated injection-site redness AE" ;
  rdfs:comment "A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000066 .

obo:OVAE_0000378 a rdfs:Class ;
  rdfs:label "ActHIB-associated injection-site pain AE" ;
  rdfs:comment "A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000986 .

obo:UBERON_0014477 a rdfs:Class ;
  rdfs:label "thoracic skeleton" ;
  rdfs:comment "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010912 .

obo:UBERON_0007524 a rdfs:Class ;
  rdfs:label "dense mesenchyme tissue" ;
  rdfs:comment "Mesenchyme with little extracellular matrix." ;
  rdfs:subClassOf obo:UBERON_0003104 .

obo:UBERON_0010881 a rdfs:Class ;
  rdfs:label "limb cartilage element" ;
  rdfs:comment "A skeletal element that is part of a limb and composed of cartilage tissue." ;
  rdfs:subClassOf obo:UBERON_0007844 , obo:UBERON_0015061 .

obo:OVAE_0000056 a rdfs:Class ;
  rdfs:label "Zostavax vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000112 .

obo:UBERON_0006241 a rdfs:Class ;
  rdfs:label "future spinal cord" ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:UBERON_0011250 a rdfs:Class ;
  rdfs:label "autopod bone" ;
  rdfs:comment "A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones." ;
  rdfs:subClassOf obo:UBERON_0002428 , obo:UBERON_0015063 .

obo:UBERON_0001021 a rdfs:Class ;
  rdfs:label "nerve" ;
  rdfs:comment "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." ;
  rdfs:subClassOf obo:UBERON_0000122 .

obo:OVAE_0000514 a rdfs:Class ;
  rdfs:label "Menveo-associated injection-site erythema AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000032 .

obo:OVAE_0000208 a rdfs:Class ;
  rdfs:label "Afluria-associated injection-site tenderness AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000984 .

obo:UBERON_0000045 a rdfs:Class ;
  rdfs:label "ganglion" ;
  rdfs:comment "A biological tissue mass, most commonly a mass of nerve cell bodies." ;
  rdfs:subClassOf obo:UBERON_0010001 .

obo:OVAE_0000389 a rdfs:Class ;
  rdfs:label "Hiberix-associated restlessness AE" ;
  rdfs:comment "A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an restlessness AE" ;
  rdfs:subClassOf obo:OAE_0001554 , obo:OVAE_0000021 .

obo:OVAE_0000075 a rdfs:Class ;
  rdfs:label "human papillomavirus vaccine adverse event"@en ;
  rdfs:comment "a virus vaccine adverse event that is associated with administration of a human papillomavirus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:NCBITaxon_11229 a rdfs:Class ;
  rdfs:label "Morbillivirus" ;
  rdfs:subClassOf obo:NCBITaxon_11159 .

obo:OVAE_0000072 a rdfs:Class ;
  rdfs:label "Haemophilus vaccine adverse event" ;
  rdfs:comment "a bacterial adverse event that is associated with administration of a Haemophilus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:UBERON_0015212 a rdfs:Class ;
  rdfs:label "lateral structure" ;
  rdfs:comment "Any structure that is placed on one side of the left-right axis of a bilaterian." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OVAE_0000114 a rdfs:Class ;
  rdfs:label "Measles virus vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Measles virus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:NCBITaxon_1239 a rdfs:Class ;
  rdfs:label "Firmicutes" ;
  rdfs:subClassOf obo:NCBITaxon_2 .

obo:OAE_0000396 a rdfs:Class ;
  rdfs:label "anorexia AE" ;
  rdfs:comment "a gustatory system AE which demonstrates a decreased sensation of appetite." ;
  rdfs:subClassOf obo:OAE_0000574 .

obo:OVAE_0000016 a rdfs:Class ;
  rdfs:label "Fluzone vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Fluzone." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:OVAE_0000580 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated local swelling AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000039 .

obo:OVAE_0000360 a rdfs:Class ;
  rdfs:label "Pediarix-associated injection-site redness AE" ;
  rdfs:comment "A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000034 .

obo:UBERON_0000092 a rdfs:Class ;
  rdfs:label "post-embryonic stage" ;
  rdfs:comment "stage succeeding embryo, including mature structure" ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/issues/344> ;
  rdfs:subClassOf obo:UBERON_0000105 .

obo:VO_0000102 a rdfs:Class ;
  rdfs:label "TENIVAC" ;
  rdfs:comment "Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use" ;
  rdfs:subClassOf obo:VO_0000732 .

obo:VO_0000943 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Poliovirus vaccine" ;
  rdfs:subClassOf obo:VO_0000732 .

obo:VO_0000034 a rdfs:Class ;
  rdfs:label "Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd" ;
  rdfs:comment "Product Name: Diphtheria & Tetanus Toxoids Adsorbed" ;
  rdfs:subClassOf obo:VO_0000732 .

obo:NCBITaxon_12083 a rdfs:Class ;
  rdfs:label "Human poliovirus 2" ;
  rdfs:subClassOf obo:NCBITaxon_138950 .

obo:OVAE_0000260 a rdfs:Class ;
  rdfs:label "Fluzone-associated headache AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000016 .

obo:OVAE_0000393 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated injection-site erythema AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000035 .

obo:PATO_0000186 a rdfs:Class ;
  rdfs:label "behavioral quality" ;
  rdfs:comment "An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation." ;
  rdfs:subClassOf obo:PATO_0001995 .

obo:OVAE_0000602 a rdfs:Class ;
  rdfs:label "IPOL-associated sleepiness AE" ;
  rdfs:comment "A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an sleepiness AE" ;
  rdfs:subClassOf obo:OAE_0001550 , obo:OVAE_0000025 .

obo:UBERON_0006601 a rdfs:Class ;
  rdfs:label "presumptive ectoderm" ;
  rdfs:comment "Presumptive structure of the blastula that will develop into ectoderm." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OVAE_0000027 a rdfs:Class ;
  rdfs:label "JE-Vax vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000113 .

obo:OVAE_0000491 a rdfs:Class ;
  rdfs:label "Ixiaro-associated myalgia AE" ;
  rdfs:comment "A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000026 .

obo:OVAE_0000428 a rdfs:Class ;
  rdfs:label "Havrix-associated injection-site pain AE" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000020 .

obo:OVAE_0000369 a rdfs:Class ;
  rdfs:label "Kinrix-associated local swelling AE" ;
  rdfs:comment "A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000028 .

obo:NCBITaxon_520 a rdfs:Class ;
  rdfs:label "Bordetella pertussis" ;
  rdfs:subClassOf obo:NCBITaxon_517 .

obo:OVAE_0000775 a rdfs:Class ;
  rdfs:label "YF-Vax-associated injection-site mass AE" ;
  rdfs:comment "A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site mass AE" ;
  rdfs:subClassOf obo:OAE_0000372 , obo:OVAE_0000055 .

obo:OVAE_0000367 a rdfs:Class ;
  rdfs:label "Kinrix-associated injection-site redness AE" ;
  rdfs:comment "A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000028 .

obo:UBERON_0004061 a rdfs:Class ;
  rdfs:label "neural tube mantle layer" ;
  rdfs:comment "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." ;
  rdfs:subClassOf obo:UBERON_0005291 , obo:UBERON_0010371 , obo:UBERON_0034707 .

obo:UBERON_0002385 a rdfs:Class ;
  rdfs:label "muscle tissue" ;
  rdfs:comment "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." ;
  rdfs:subClassOf obo:UBERON_0000479 , obo:UBERON_0004120 .

obo:UBERON_0004880 a rdfs:Class ;
  rdfs:label "chordamesoderm" ;
  rdfs:comment "The central region of trunk mesoderm. This tissue forms the notochord" ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:UBERON_0003221 a rdfs:Class ;
  rdfs:label "phalanx" ;
  rdfs:comment "Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits." ;
  rdfs:subClassOf obo:UBERON_0003606 , obo:UBERON_0012357 , obo:UBERON_0015023 .

obo:NCBITaxon_11161 a rdfs:Class ;
  rdfs:label "Mumps virus" ;
  rdfs:subClassOf obo:NCBITaxon_11159 .

obo:OVAE_0000483 a rdfs:Class ;
  rdfs:label "Cervarix-associated fatigue AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000064 .

obo:OVAE_0000338 a rdfs:Class ;
  rdfs:label "Tripedia-associated local swelling AE" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000049 .

obo:OVAE_0000276 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated headache AE" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000018 .

obo:UBERON_0001005 a rdfs:Class ;
  rdfs:label "respiratory airway" ;
  rdfs:comment "An airway through which respiratory air passes in organisms." ;
  rdfs:subClassOf obo:UBERON_0003103 .

obo:OVAE_0000616 a rdfs:Class ;
  rdfs:label "RabAvert-associated injection-site pain AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000041 .

obo:VO_0000585 a rdfs:Class ;
  rdfs:label "immunization objective" ;
  rdfs:comment "immunization objective is the specification of an objective to achieve immunization." ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OVAE_0000703 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated fever AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000047 .

obo:UBERON_0003852 a rdfs:Class ;
  rdfs:label "rhombencephalon neural crest" ;
  rdfs:comment "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." ;
  rdfs:subClassOf obo:UBERON_0002342 , obo:UBERON_0003099 .

obo:OVAE_0000670 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated musculoskeletal pain AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an musculoskeletal pain AE" ;
  rdfs:subClassOf obo:OAE_0000643 , obo:OVAE_0000046 .

obo:OVAE_0000296 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated decreased appetite AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000011 .

obo:UBERON_0015063 a rdfs:Class ;
  rdfs:label "autopod endochondral element" ;
  rdfs:comment "A endochondral element that is part of a autopod region." ;
  rdfs:subClassOf obo:UBERON_0010363 , obo:UBERON_0015061 .

obo:UBERON_0000479 a rdfs:Class ;
  rdfs:label "tissue" ;
  rdfs:comment "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:OVAE_0000648 a rdfs:Class ;
  rdfs:label "Meruvax II-associated vomiting AE" ;
  rdfs:comment "A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000033 .

obo:VO_0010745 a rdfs:Class ;
  rdfs:label "Vaqta" ;
  rdfs:comment "Trade Name: Vaqta" ;
  rdfs:subClassOf obo:VO_0000646 .

obo:UBERON_0006717 a rdfs:Class ;
  rdfs:label "autopodial skeleton" ;
  rdfs:comment "The collection of all skeletal elements in an autopodium region." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

obo:UBERON_0006003 a rdfs:Class ;
  rdfs:label "integumentary adnexa" ;
  rdfs:comment "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." ;
  rdfs:subClassOf obo:UBERON_0000064 .

obo:UBERON_0004141 a rdfs:Class ;
  rdfs:label "heart tube" ;
  rdfs:comment "An epithelial tube that will give rise to the mature heart." ;
  rdfs:subClassOf obo:UBERON_0003914 , obo:UBERON_0005291 , obo:UBERON_0012275 .

obo:VO_0000590 a rdfs:Class ;
  rdfs:label "vaccine preparation" ;
  rdfs:comment "vaccine preparation is a manufacturing process to produce a vaccine." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0000299 a rdf:Property ;
  rdfs:label "has_specified_output" ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:UBERON_0004872 a rdfs:Class ;
  rdfs:label "splanchnic layer of lateral plate mesoderm" ;
  rdfs:comment "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:OVAE_0000034 a rdfs:Class ;
  rdfs:label "Pediarix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000106 .

obo:OVAE_0000498 a rdfs:Class ;
  rdfs:label "JE-Vax-associated rash AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000027 .

obo:OVAE_0000525 a rdfs:Class ;
  rdfs:label "MenHibrix-associated injection-site pain AE" ;
  rdfs:comment "A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000030 .

obo:UBERON_0003102 a rdfs:Class ;
  rdfs:label "surface structure" ;
  rdfs:comment "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OVAE_0000358 a rdfs:Class ;
  rdfs:label "Daptacel-associated fever AE" ;
  rdfs:comment "A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000066 .

obo:OVAE_0000442 a rdfs:Class ;
  rdfs:label "Twinrix-associated injection-site muscular soreness AE" ;
  rdfs:comment "A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an injection-site muscular soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000050 .

obo:VO_0000654 a rdfs:Class ;
  rdfs:label "Measles virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Measles virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:VO_0000063 a rdfs:Class ;
  rdfs:label "Imovax Rabies (USA)" ;
  rdfs:comment "Product Name: Rabies Vaccine" ;
  rdfs:subClassOf obo:VO_0000650 .

obo:OVAE_0000356 a rdfs:Class ;
  rdfs:label "Daptacel-associated inconsolable crying AE" ;
  rdfs:comment "A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an inconsolable crying AE" ;
  rdfs:subClassOf obo:OAE_0000215 , obo:OVAE_0000066 .

obo:OVAE_0000316 a rdfs:Class ;
  rdfs:label "Biothrax-associated injection-site tenderness AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000061 .

obo:UBERON_0009842 a rdfs:Class ;
  rdfs:label "glandular acinus" ;
  rdfs:comment "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form." ;
  rdfs:subClassOf obo:UBERON_0034922 .

obo:UBERON_0009749 a rdfs:Class ;
  rdfs:label "limb mesenchyme" ;
  rdfs:comment "The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells." ;
  rdfs:subClassOf obo:UBERON_0003104 .

obo:UBERON_0016888 a rdfs:Class ;
  rdfs:label "transitional anatomical structure" ;
  rdfs:comment "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:OVAE_0000407 a rdfs:Class ;
  rdfs:label "Comvax-associated injection-site soreness AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000065 .

obo:UBERON_0000456 a rdfs:Class ;
  rdfs:label "bodily secretion" ;
  rdfs:comment "A portion of organism substance that is produced by exocrine glands." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:VO_0000772 a rdfs:Class ;
  rdfs:label "Streptococcal vaccine" ;
  rdfs:comment "A bacterial vaccine that prevents streptococcal infections." ;
  rdfs:subClassOf obo:VO_0000165 .

obo:VO_0000982 a rdfs:Class ;
  rdfs:label "FluMist Quadrivalent"@en ;
  rdfs:subClassOf obo:VO_0000642 .

obo:OVAE_0000771 a rdfs:Class ;
  rdfs:label "YF-Vax-associated low grade fever AE" ;
  rdfs:comment "A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an low grade fever AE" ;
  rdfs:subClassOf obo:OAE_0000639 , obo:OVAE_0000055 .

obo:VO_0000213 a rdfs:Class ;
  rdfs:label "hypersensitivity to chicken product" ;
  rdfs:subClassOf obo:VO_0000207 .

obo:VO_0003051 a rdfs:Class ;
  rdfs:label "percutaneous route" ;
  rdfs:comment "epicutaneous (application onto the skin), e" ;
  rdfs:subClassOf obo:VO_0000574 .

obo:OAE_0000055 a rdfs:Class ;
  rdfs:label "contraindication" ;
  rdfs:comment "A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment." ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OVAE_0000230 a rdfs:Class ;
  rdfs:label "Fluarix-associated gastrointestinal disorder AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an gastrointestinal disorder AE" ;
  rdfs:subClassOf obo:OAE_0000455 , obo:OVAE_0000010 .

obo:OVAE_0000049 a rdfs:Class ;
  rdfs:label "Tripedia vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000102 .

obo:OVAE_0000730 a rdfs:Class ;
  rdfs:label "Adacel-associated headache AE" ;
  rdfs:comment "A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000988 .

obo:OVAE_0000285 a rdfs:Class ;
  rdfs:label "FluMist Quadrivalent-associated fever AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000014 .

obo:UBERON_0002168 a rdfs:Class ;
  rdfs:label "left lung" ;
  rdfs:comment "Lung which consists of the left upper lobe and left lower lobe.[FMA]" ;
  rdfs:subClassOf obo:UBERON_0002048 .

obo:BSPO_0000120 a rdf:Property ;
  rdfs:label "in_left_side_of" ;
  rdfs:comment "X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BSPO_0000126 .

obo:OAE_0000403 a rdfs:Class ;
  rdfs:label "hypertension AE" ;
  rdfs:comment "an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" ;
  rdfs:subClassOf obo:OAE_0000381 .

obo:OVAE_0000402 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated otitis media AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an otitis media AE" ;
  rdfs:subClassOf obo:OAE_0000340 , obo:OVAE_0000035 .

obo:OVAE_0000311 a rdfs:Class ;
  rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated arthralgia AE" ;
  rdfs:comment "A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000074 .

obo:UBERON_0034713 a rdfs:Class ;
  rdfs:label "cranial neuron projection bundle" ;
  rdfs:comment "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain" ;
  rdfs:subClassOf obo:UBERON_0000122 .

obo:NCBITaxon_10912 a rdfs:Class ;
  rdfs:label "Rotavirus" ;
  rdfs:subClassOf obo:NCBITaxon_689832 .

obo:VO_0000120 a rdfs:Class ;
  rdfs:label "Vivotif (USA)" ;
  rdfs:comment "Product Name: Typhoid Vaccine Live Oral Ty21a" ;
  rdfs:subClassOf obo:VO_0000671 .

obo:UBERON_0004923 a rdfs:Class ;
  rdfs:label "organ component layer" ;
  rdfs:comment "A part of a wall of an organ that forms a layer." ;
  rdfs:subClassOf obo:UBERON_0000064 .

obo:OVAE_0000009 a rdfs:Class ;
  rdfs:label "Flublok vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Flublok." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:NCBITaxon_9347 a rdfs:Class ;
  rdfs:label "Eutheria" ;
  rdfs:subClassOf obo:NCBITaxon_40674 .

obo:UBERON_0011272 a rdfs:Class ;
  rdfs:label "embryonic skin basal layer" ;
  rdfs:subClassOf obo:UBERON_0000490 , obo:UBERON_0010371 .

obo:OVAE_0000623 a rdfs:Class ;
  rdfs:label "RabAvert-associated arthralgia AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000041 .

obo:OVAE_0000252 a rdfs:Class ;
  rdfs:label "Fluvirin-associated mild hypersensitity AE" ;
  rdfs:comment "A Fluvirin vaccine adverse event that is associated with an administration of Fluvirin and displays an mild hypersensitity AE" ;
  rdfs:subClassOf obo:OAE_0001552 , obo:OVAE_0000015 .

obo:UBERON_0004022 a rdfs:Class ;
  rdfs:label "germinal neuroepithelium" ;
  rdfs:comment "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells" ;
  rdfs:subClassOf obo:UBERON_0005291 , obo:UBERON_0010371 , obo:UBERON_0034706 .

obo:OVAE_0000480 a rdfs:Class ;
  rdfs:label "Cervarix-associated injection-site pain AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000064 .

obo:OVAE_0000031 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135 vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000079 .

obo:UBERON_0006658 a rdfs:Class ;
  rdfs:label "interphalangeal joint" ;
  rdfs:comment "A joint that connects one phalanx to another along a proximodistal axis." ;
  rdfs:subClassOf obo:UBERON_0000982 , obo:UBERON_0003841 , obo:UBERON_0011139 .

obo:OAE_0000331 a rdfs:Class ;
  rdfs:label "lymphadenitis AE" ;
  rdfs:comment "A lymphadenopathy AE that results in swollen/enlarged lymph nodes" ;
  rdfs:subClassOf obo:OAE_0001147 .

obo:VO_0000047 a rdfs:Class ;
  rdfs:label "Fluzone" ;
  rdfs:comment "Trade Name: Fluzone" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:OVAE_0000215 a rdfs:Class ;
  rdfs:label "Agriflu-associated myalgia AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000060 .

obo:OVAE_0000605 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated injection-site pain AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000022 .

obo:OVAE_0000327 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site induration AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000007 .

obo:OVAE_0000204 a rdfs:Class ;
  rdfs:label "Afluria-associated headache AE" ;
  rdfs:comment "A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000984 .

obo:OVAE_0000418 a rdfs:Class ;
  rdfs:label "Comvax-associated upper respiratory tract infection AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an upper respiratory tract infection AE" ;
  rdfs:subClassOf obo:OAE_0000358 , obo:OVAE_0000065 .

obo:OVAE_0000344 a rdfs:Class ;
  rdfs:label "Tripedia-associated irritability AE" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000049 .

obo:UBERON_5102544 a rdfs:Class ;
  rdfs:label "individual digit of digitopodial skeleton" ;
  rdfs:comment "A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

obo:OVAE_0000371 a rdfs:Class ;
  rdfs:label "Kinrix-associated fever AE" ;
  rdfs:comment "A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000028 .

obo:UBERON_0003842 a rdfs:Class ;
  rdfs:label "neural tube lumen" ;
  rdfs:comment "An anatomical space that surrounded_by a neural tube." ;
  rdfs:subClassOf obo:UBERON_0000464 .

obo:UBERON_0013703 a rdfs:Class ;
  rdfs:label "integumentary projection" ;
  rdfs:comment "Anatomical projection that is part of the integumentl system." ;
  rdfs:subClassOf obo:UBERON_0004529 , obo:UBERON_0006003 .

obo:BFO_0000148 a rdfs:Class ;
  rdfs:label "zero-dimensional temporal region"@en ;
  rdfs:subClassOf obo:BFO_0000008 .

obo:OVAE_0000711 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated injection-site induration AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000048 .

obo:VO_0000743 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine" ;
  rdfs:subClassOf obo:VO_0000742 .

obo:UBERON_0003055 a rdfs:Class ;
  rdfs:label "periderm" ;
  rdfs:comment "A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis." ;
  rdfs:subClassOf obo:UBERON_0000487 , obo:UBERON_0010371 .

obo:UBERON_0006314 a rdfs:Class ;
  rdfs:label "bodily fluid" ;
  rdfs:comment "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:UBERON_0011585 a rdfs:Class ;
  rdfs:label "cell condensation" ;
  rdfs:comment "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OVAE_0000333 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated pain AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an pain AE" ;
  rdfs:subClassOf obo:OAE_0000374 , obo:OVAE_0000007 .

obo:UBERON_0002193 a rdfs:Class ;
  rdfs:label "hemolymphoid system" ;
  rdfs:comment "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OAE_0000077 a rdfs:Class ;
  rdfs:label "clinical laboratory test"@en ;
  rdfs:comment "a planned process that is specifically a test conducted in a clinical laboratory. " ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:UBERON_0003080 a rdfs:Class ;
  rdfs:label "anterior neural tube" ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:OAE_0003230 a rdfs:Class ;
  rdfs:label "behavior abnormal quality"@en ;
  rdfs:subClassOf obo:PATO_0000186 .

obo:UBERON_0002530 a rdfs:Class ;
  rdfs:label "gland" ;
  rdfs:comment "an organ that functions as a secretory or excretory organ" ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OVAE_0000700 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid-associated urticaria AE" ;
  rdfs:comment "A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an urticaria AE" ;
  rdfs:subClassOf obo:OAE_0000376 , obo:OVAE_0000047 .

obo:OVAE_0000476 a rdfs:Class ;
  rdfs:label "Gardasil-associated local swelling AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000019 .

obo:OVAE_0000464 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated headache AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000042 .

obo:UBERON_0009616 a rdfs:Class ;
  rdfs:label "presumptive midbrain" ;
  rdfs:comment "A presumptive structure that has the potential to develop into a midbrain." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:UBERON_0000153 a rdfs:Class ;
  rdfs:label "anterior region of body" ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:OVAE_0000255 a rdfs:Class ;
  rdfs:label "Fluzone-associated injection-site redness AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000016 .

obo:OVAE_0000681 a rdfs:Class ;
  rdfs:label "Decavac-associated muscular weakness AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an muscular weakness AE" ;
  rdfs:subClassOf obo:OAE_0000333 , obo:OVAE_0000067 .

obo:VO_0000727 a rdfs:Class ;
  rdfs:label "Herpesvirus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Herpesvirus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:NCBITaxon_12092 a rdfs:Class ;
  rdfs:label "Hepatitis A virus" ;
  rdfs:subClassOf obo:NCBITaxon_12058 .

obo:OAE_0000650 a rdfs:Class ;
  rdfs:label "hematoma AE" ;
  rdfs:comment "an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise." ;
  rdfs:subClassOf obo:OAE_0000493 .

obo:OVAE_0000487 a rdfs:Class ;
  rdfs:label "Cervarix-associated arthralgia AE" ;
  rdfs:comment "A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000064 .

obo:VO_0000664 a rdfs:Class ;
  rdfs:label "Poliovirus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Poliovirus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:VO_0000642 a rdfs:Class ;
  rdfs:label "Influenza virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with influenza virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:OVAE_0000274 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated injection-site pain AE" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000018 .

obo:OAE_0000306 a rdfs:Class ;
  rdfs:label "convulsion AE" ;
  rdfs:comment "convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body" ;
  rdfs:subClassOf obo:OAE_0000435 .

obo:UBERON_0011676 a rdfs:Class ;
  rdfs:label "subdivision of organism along main body axis" ;
  rdfs:comment "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:VO_0000738 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis vaccine" ;
  rdfs:subClassOf obo:VO_0000732 .

obo:OVAE_0000002 a rdfs:Class ;
  rdfs:label "virus vaccine adverse event" ;
  rdfs:comment "a vaccine adverse event that is associated with administration of a virus vaccine" ;
  rdfs:subClassOf obo:OAE_0000004 .

obo:OVAE_0000399 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated vomiting AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000035 .

obo:UBERON_0004716 a rdfs:Class ;
  rdfs:label "conceptus" ;
  rdfs:comment "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OVAE_0000117 a rdfs:Class ;
  rdfs:label "smallpox vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of smallpox vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:OAE_0000465 a rdfs:Class ;
  rdfs:label "ear  AE" ;
  rdfs:comment "an AE that occurs in ear." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:UBERON_0034925 a rdfs:Class ;
  rdfs:label "anatomical collection" ;
  rdfs:comment "A collection of anatomical structures that are alike in terms of their morphology or developmental origin." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OVAE_0000500 a rdfs:Class ;
  rdfs:label "JE-Vax-associated dizziness AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an dizziness AE" ;
  rdfs:subClassOf obo:OAE_0000388 , obo:OVAE_0000027 .

obo:OVAE_0000453 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated rhinitis AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an rhinitis AE" ;
  rdfs:subClassOf obo:OAE_0000350 , obo:OVAE_0000042 .

obo:VO_0000113 a rdfs:Class ;
  rdfs:label "Twinrix" ;
  rdfs:comment "Product Name: Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine" ;
  rdfs:subClassOf obo:VO_0000745 .

obo:UBERON_0002329 a rdfs:Class ;
  rdfs:label "somite" ;
  rdfs:comment "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." ;
  rdfs:subClassOf obo:UBERON_0005423 , obo:UBERON_0007503 , obo:UBERON_0012275 .

obo:UBERON_0007811 a rdfs:Class ;
  rdfs:label "craniocervical region" ;
  rdfs:comment "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:VO_0010637 a rdfs:Class ;
  rdfs:label "Rubella virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Rubella virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:UBERON_0001785 a rdfs:Class ;
  rdfs:label "cranial nerve" ;
  rdfs:comment "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." ;
  rdfs:subClassOf obo:UBERON_0001021 , obo:UBERON_0011779 , obo:UBERON_0034713 .

obo:VO_0001126 a rdfs:Class ;
  rdfs:label "Agriflu" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:UBERON_0010314 a rdfs:Class ;
  rdfs:label "structure with developmental contribution from neural crest" ;
  rdfs:comment "An anatomical structure that has some part that develops from the neural crest." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0006984 a rdfs:Class ;
  rdfs:label "anatomical surface" ;
  rdfs:comment "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n" ;
  rdfs:subClassOf obo:UBERON_0000466 .

obo:BFO_0000003 a rdfs:Class ;
  rdfs:label "occurrent"@en ;
  rdfs:comment "An entity that has temporal parts and that happens, unfolds or develops through time."@en ;
  rdfs:subClassOf obo:BFO_0000001 .

obo:UBERON_0003084 a rdfs:Class ;
  rdfs:label "heart primordium" ;
  rdfs:comment "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." ;
  rdfs:subClassOf obo:UBERON_0001048 .

obo:OVAE_0000613 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated dizziness AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an dizziness AE" ;
  rdfs:subClassOf obo:OAE_0000388 , obo:OVAE_0000022 .

obo:VO_0000495 a rdfs:Class ;
  rdfs:label "induction of adaptive immune response to antigen" ;
  rdfs:comment "induction of adaptive immune response to antigen is an active immunization process that results in induction of adaptive immune response to some antigens, for example, in a vaccine." ;
  rdfs:subClassOf obo:VO_0000491 .

obo:NCBITaxon_10240 a rdfs:Class ;
  rdfs:label "Poxviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35237 .

obo:OVAE_0000233 a rdfs:Class ;
  rdfs:label "Fluarix-associated local swelling AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000010 .

obo:OAE_0001839 a rdfs:Class ;
  rdfs:label "AE severity G4"@en ;
  rdfs:comment "a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral)." ;
  rdfs:subClassOf obo:OAE_0001750 .

obo:VO_0000067 a rdfs:Class ;
  rdfs:label "Kinrix" ;
  rdfs:comment "Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine" ;
  rdfs:subClassOf obo:VO_0000742 .

obo:OVAE_0000692 a rdfs:Class ;
  rdfs:label "Tenivac-associated malaise AE" ;
  rdfs:comment "A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000045 .

obo:UBERON_0006598 a rdfs:Class ;
  rdfs:label "presumptive structure" ;
  rdfs:comment "Portion of embryonic tissue determined by fate mapping to become a structure." ;
  rdfs:subClassOf obo:UBERON_0005423 .

obo:UBERON_0004456 a rdfs:Class ;
  rdfs:label "entire sense organ system" ;
  rdfs:comment "Sum of all sensory systems in an organism." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OVAE_0000042 a rdfs:Class ;
  rdfs:label "Recombivax HB vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000111 .

obo:UBERON_0001016 a rdfs:Class ;
  rdfs:label "nervous system" ;
  rdfs:comment "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OVAE_0000431 a rdfs:Class ;
  rdfs:label "Havrix-associated drowsiness" ;
  rdfs:comment "A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000020 .

obo:NCBITaxon_689832 a rdfs:Class ;
  rdfs:label "Sedoreovirinae" ;
  rdfs:subClassOf obo:NCBITaxon_10880 .

obo:NCBITaxon_33213 a rdfs:Class ;
  rdfs:label "Bilateria" ;
  rdfs:subClassOf obo:NCBITaxon_33154 .

obo:OVAE_0000764 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated vomiting AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an vomiting AE" ;
  rdfs:subClassOf obo:OAE_0000601 , obo:OVAE_0000051 .

obo:NCBITaxon_35278 a rdfs:Class ;
  rdfs:label "ssRNA positive-strand viruses, no DNA stage" ;
  rdfs:subClassOf obo:NCBITaxon_439488 .

obo:VO_0000124 a rdfs:Class ;
  rdfs:label "Zostavax" ;
  rdfs:comment "Trade Name: Zostavax" ;
  rdfs:subClassOf obo:VO_0000419 .

obo:OVAE_0000005 a rdfs:Class ;
  rdfs:label "cancer vaccine adverse event" ;
  rdfs:comment "a vaccine adverse event that is associated with administration of a cancer vaccine" ;
  rdfs:subClassOf obo:OAE_0000004 .

obo:OVAE_0000382 a rdfs:Class ;
  rdfs:label "ActHIB-associated irritability AE" ;
  rdfs:comment "A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000986 .

obo:OVAE_0000753 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated injection-site tenderness AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000051 .

obo:UBERON_0008897 a rdfs:Class ;
  rdfs:label "fin" ;
  rdfs:comment "An external projection of an aquatic animal as a fish used in propelling or guiding the body[BTO]." ;
  rdfs:subClassOf obo:UBERON_0000026 .

obo:OVAE_0000263 a rdfs:Class ;
  rdfs:label "Fluzone-associated headache AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000016 .

obo:VO_0000433 a rdfs:Class ;
  rdfs:label "vaccinia virus vaccine" ;
  rdfs:comment "Vaccinia virus is well known for its role as a vaccine that helped eradicate the smallpox disease, making it the first human disease to be successfully eradicated by science." ;
  rdfs:subClassOf obo:VO_0000651 .

obo:VO_0000419 a rdfs:Class ;
  rdfs:label "Varicella-zoster virus live vaccine" ;
  rdfs:comment "a Varicella-zoster virus vaccine that is live attenuated." ;
  rdfs:subClassOf obo:VO_0000669 .

obo:VO_0000625 a rdfs:Class ;
  rdfs:label "conjugate vaccine role"@en ;
  rdfs:comment "a vaccine role that indicates the vaccine being a conjugate vaccine. " ;
  rdfs:subClassOf obo:VO_0000615 .

obo:OVAE_0000529 a rdfs:Class ;
  rdfs:label "MenHibrix-associated drowsiness" ;
  rdfs:comment "A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an drowsiness" ;
  rdfs:subClassOf obo:OAE_0000391 , obo:OVAE_0000030 .

obo:OVAE_0000494 a rdfs:Class ;
  rdfs:label "JE-Vax-associated local swelling AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000027 .

obo:CHEBI_7507 a rdfs:Class ;
  rdfs:label "neomycin" ;
  rdfs:comment "A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections." ;
  rdfs:subClassOf obo:CHEBI_23367 .

obo:UBERON_0001136 a rdfs:Class ;
  rdfs:label "mesothelium" ;
  rdfs:comment "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. http://en.wikipedia.org/wiki/ The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." ;
  rdfs:subClassOf obo:UBERON_0000487 , obo:UBERON_0012275 .

obo:OVAE_0000266 a rdfs:Class ;
  rdfs:label "Fluzone High-Dose-associated injection-site pain AE" ;
  rdfs:comment "A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an injection-site pain AE" ;
  rdfs:subClassOf obo:OAE_0000369 , obo:OVAE_0000017 .

obo:OVAE_0000045 a rdfs:Class ;
  rdfs:label "Tenivac vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000101 .

obo:OAE_0000084 a rdfs:Class ;
  rdfs:label "cardiac disorder AE" ;
  rdfs:comment "a cardiovascular disorder AE that has a cardiac disorder outcome. " ;
  rdfs:subClassOf obo:OAE_0000493 .

obo:OVAE_0000413 a rdfs:Class ;
  rdfs:label "Comvax-associated diarrhea AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an diarrhea AE" ;
  rdfs:subClassOf obo:OAE_0000616 , obo:OVAE_0000065 .

obo:OAE_0001552 a rdfs:Class ;
  rdfs:label "mild hypersensitivity AE"@en ;
  rdfs:comment "a hypersensitivity AE that is mild." ;
  rdfs:subClassOf obo:OAE_0000584 .

obo:VO_0010715 a rdfs:Class ;
  rdfs:label "Hiberix" ;
  rdfs:comment "Trade Name: Hiberix" ;
  rdfs:subClassOf obo:VO_0000662 .

obo:UBERON_0002240 a rdfs:Class ;
  rdfs:label "spinal cord" ;
  rdfs:comment "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)" ;
  rdfs:subClassOf obo:UBERON_0000489 , obo:UBERON_0004121 , obo:UBERON_0005174 , obo:UBERON_0010314 .

obo:OAE_0000493 a rdfs:Class ;
  rdfs:label "cardiovascular AE" ;
  rdfs:comment "an AE that occurs in cardiovascular system." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OAE_0000374 a rdfs:Class ;
  rdfs:label "pain AE" ;
  rdfs:comment "a sensory capability AE that has an outcome of pain in a patient" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:VO_0000615 a rdfs:Class ;
  rdfs:label "vaccine role"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0000562 a rdfs:Class ;
  rdfs:label "therapeutic vaccine function" ;
  rdfs:comment "The therapeutic vaccine function is a function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which ameliorates a specific disorder." ;
  rdfs:subClassOf obo:VO_0000278 .

obo:OVAE_0000299 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated headache AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000011 .

obo:UBERON_0005157 a rdfs:Class ;
  rdfs:label "epithelial fold" ;
  rdfs:comment "An epithelial sheet bent on a linear axis." ;
  rdfs:subClassOf obo:UBERON_0000483 .

obo:VO_0000033 a rdfs:Class ;
  rdfs:label "Diphtheria and Tetanus Toxoids Adsorbed USP by Sanofi Pasteur Inc" ;
  rdfs:comment "Product Name: Diphtheria & Tetanus Toxoids Adsorbed" ;
  rdfs:subClassOf obo:VO_0000732 .

obo:OVAE_0000020 a rdfs:Class ;
  rdfs:label "Havrix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000109 .

obo:OVAE_0000271 a rdfs:Class ;
  rdfs:label "Fluzone Intradermal-associated injection-site erythema AE" ;
  rdfs:comment "A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site erythema AE" ;
  rdfs:subClassOf obo:OAE_0000644 , obo:OVAE_0000018 .

obo:UBERON_0000464 a rdfs:Class ;
  rdfs:label "anatomical space" ;
  rdfs:comment "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." ;
  rdfs:subClassOf obo:UBERON_0000466 .

obo:UBERON_0009569 a rdfs:Class ;
  rdfs:label "subdivision of trunk" ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:OVAE_0000609 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated headache AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000022 .

obo:OVAE_0000439 a rdfs:Class ;
  rdfs:label "Vaqta-associated injection-site muscular soreness AE" ;
  rdfs:comment "A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site muscular soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000052 .

obo:OVAE_0000532 a rdfs:Class ;
  rdfs:label "Menactra-associated injection-site tenderness AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000029 .

obo:UBERON_0007135 a rdfs:Class ;
  rdfs:label "neural keel" ;
  rdfs:comment "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." ;
  rdfs:subClassOf obo:UBERON_0016879 .

obo:UBERON_0011823 a rdfs:Class ;
  rdfs:label "dense connective tissue" ;
  rdfs:comment "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets" ;
  rdfs:subClassOf obo:UBERON_0002384 .

obo:OAE_0000624 a rdfs:Class ;
  rdfs:label "abnormal body temperature AE" ;
  rdfs:comment "a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being"@en ;
  rdfs:subClassOf obo:OAE_0000555 .

obo:UBERON_0011216 a rdfs:Class ;
  rdfs:label "organ system subdivision" ;
  rdfs:comment "A subdivision of an anatomical system." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:OVAE_0000685 a rdfs:Class ;
  rdfs:label "Decavac-associated nausea AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000067 .

obo:OAE_0000004 a rdfs:Class ;
  rdfs:label "vaccine adverse event" ;
  rdfs:comment "an adverse event that occurs after a vaccination." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:UBERON_0002020 a rdfs:Class ;
  rdfs:label "gray matter" ;
  rdfs:comment "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." ;
  rdfs:subClassOf obo:UBERON_0011215 .

obo:OVAE_0000107 a rdfs:Class ;
  rdfs:label "Salmonella vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of Salmonella vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:OVAE_0000293 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated local swelling AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000011 .

obo:OVAE_0000608 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated itching" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an itching" ;
  rdfs:subClassOf obo:OAE_0000373 , obo:OVAE_0000022 .

obo:UBERON_0003099 a rdfs:Class ;
  rdfs:label "cranial neural crest" ;
  rdfs:comment "neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." ;
  rdfs:subClassOf obo:UBERON_0004121 , obo:UBERON_0005291 , obo:UBERON_0010314 .

obo:UBERON_0014371 a rdfs:Class ;
  rdfs:label "future telencephalon" ;
  rdfs:comment "Embryonic structure that gives rise to the telencephalon." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OVAE_0000341 a rdfs:Class ;
  rdfs:label "Tripedia-associated anorexia AE" ;
  rdfs:comment "A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an anorexia AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000049 .

obo:NCBITaxon_333774 a rdfs:Class ;
  rdfs:label "unclassified Papillomaviridae" ;
  rdfs:subClassOf obo:NCBITaxon_151340 .

obo:OVAE_0000659 a rdfs:Class ;
  rdfs:label "Tetanus and Diptheria Toxoids Absorbed-associated injection-site induration AE" ;
  rdfs:comment "A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000046 .

obo:UBERON_0004120 a rdfs:Class ;
  rdfs:label "mesoderm-derived structure" ;
  rdfs:comment "An anatomical structure that develops (entirely or partially) from the mesoderm." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:NCBITaxon_1236 a rdfs:Class ;
  rdfs:label "Gammaproteobacteria" ;
  rdfs:subClassOf obo:NCBITaxon_1224 .

obo:UBERON_0002534 a rdfs:Class ;
  rdfs:label "paired fin" ;
  rdfs:comment "Fin that is one of a pair located ventrally on the organism." ;
  rdfs:subClassOf obo:UBERON_0004708 , obo:UBERON_0008897 .

obo:VO_0000851 a rdfs:Class ;
  rdfs:label "vaccine preservative" ;
  rdfs:subClassOf obo:VO_0000179 .

obo:UBERON_0007005 a rdfs:Class ;
  rdfs:label "cardiac mesoderm" ;
  rdfs:comment "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005291 .

obo:NCBITaxon_11308 a rdfs:Class ;
  rdfs:label "Orthomyxoviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35301 .

obo:OAE_0000551 a rdfs:Class ;
  rdfs:label "hypotension AE" ;
  rdfs:comment "an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" ;
  rdfs:subClassOf obo:OAE_0000381 .

obo:VO_0000073 a rdfs:Class ;
  rdfs:label "Meruvax II" ;
  rdfs:comment "Trade Name: Meruvax II" ;
  rdfs:subClassOf obo:VO_0010637 .

obo:OVAE_0000300 a rdfs:Class ;
  rdfs:label "Fluarix Quadrivalent-associated arthralgia AE" ;
  rdfs:comment "A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an arthralgia AE" ;
  rdfs:subClassOf obo:OAE_0000385 , obo:OVAE_0000011 .

obo:OAE_0000363 a rdfs:Class ;
  rdfs:label "infection AE" ;
  rdfs:comment "an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OVAE_0000691 a rdfs:Class ;
  rdfs:label "Tenivac-associated local swelling AE" ;
  rdfs:comment "A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000045 .

obo:OGG_1000001224 a rdfs:Class ;
  rdfs:label "genome of Proteobacteria" ;
  rdfs:comment "The genome of an organism of Proteobacteria" ;
  rdfs:subClassOf obo:OGG_1000000002 .

obo:OVAE_0000390 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated irritability AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000035 .

obo:VO_0003049 a rdfs:Class ;
  rdfs:label "vaccine conjugate protein" ;
  rdfs:comment "The conjugate protein is a part of a conjugate vaccine and acts as a carrier protein that is covalently attached to a vaccine antigen with poor antigenicity (e.g., a polysaccharide). A conjugate protein is able to induce T-cell-dependent immune responses and stimulate the production of immune memory." ;
  rdfs:subClassOf obo:VO_0000179 .

obo:UBERON_0003258 a rdfs:Class ;
  rdfs:label "endoderm of foregut" ;
  rdfs:comment "An endoderm that is part of a foregut [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0000490 , obo:UBERON_0005911 , obo:UBERON_0015833 .

obo:OVAE_0000490 a rdfs:Class ;
  rdfs:label "Ixiaro-associated headache AE" ;
  rdfs:comment "A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000026 .

obo:OVAE_0000258 a rdfs:Class ;
  rdfs:label "Fluzone-associated myalgia AE" ;
  rdfs:comment "A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000016 .

obo:NCBITaxon_543 a rdfs:Class ;
  rdfs:label "Enterobacteriaceae" ;
  rdfs:subClassOf obo:NCBITaxon_1236 .

obo:UBERON_0001041 a rdfs:Class ;
  rdfs:label "foregut" ;
  rdfs:comment "Anterior subdivision of a digestive tract." ;
  rdfs:subClassOf obo:UBERON_0004921 .

obo:OAE_0001836 a rdfs:Class ;
  rdfs:label "AE severity G1"@en ;
  rdfs:comment "a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated." ;
  rdfs:subClassOf obo:OAE_0001750 .

obo:NCBITaxon_314293 a rdfs:Class ;
  rdfs:label "Simiiformes" ;
  rdfs:subClassOf obo:NCBITaxon_314146 .

obo:OAE_0000490 a rdfs:Class ;
  rdfs:label "acute brain syndrome AE" ;
  rdfs:comment "a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention.  " ;
  rdfs:subClassOf obo:OAE_0000364 .

obo:OAE_0000580 a rdfs:Class ;
  rdfs:label "behavioral and neurological AE" ;
  rdfs:comment "an adverse event that has an outcome of an abnormal behavior and neurological phenotype." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:UBERON_0034921 a rdfs:Class ;
  rdfs:label "multi organ part structure" ;
  rdfs:comment "An multicellular anatomical structure that has subparts of multiple organs as a part." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:UBERON_0002049 a rdfs:Class ;
  rdfs:label "vasculature" ;
  rdfs:comment "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." ;
  rdfs:subClassOf obo:UBERON_0000477 .

obo:UBERON_0001555 a rdfs:Class ;
  rdfs:label "digestive tract" ;
  rdfs:comment "A tube extending from the mouth to the anus." ;
  rdfs:subClassOf obo:UBERON_0000025 .

obo:UBERON_0001690 a rdfs:Class ;
  rdfs:label "ear" ;
  rdfs:comment "Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." ;
  rdfs:subClassOf obo:UBERON_0000020 , obo:UBERON_0010314 .

obo:BFO_0000031 a rdfs:Class ;
  rdfs:label "generically dependent continuant"@en ;
  rdfs:comment "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:VO_0000748 a rdfs:Class ;
  rdfs:label "Papillomavirus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Papillomavirus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:NCBITaxon_1513 a rdfs:Class ;
  rdfs:label "Clostridium tetani" ;
  rdfs:subClassOf obo:NCBITaxon_1485 .

obo:OVAE_0000001 a rdfs:Class ;
  rdfs:label "bacterial vaccine adverse event" ;
  rdfs:comment "a vaccine adverse event that is associated with administration of a bacterial vaccine" ;
  rdfs:subClassOf obo:OAE_0000004 .

obo:OVAE_0000348 a rdfs:Class ;
  rdfs:label "Infanrix-associated fever AE" ;
  rdfs:comment "A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000023 .

obo:UBERON_0004733 a rdfs:Class ;
  rdfs:label "segmental subdivision of hindbrain" ;
  rdfs:comment "An organ subunit that is part of a hindbrain [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0000063 , obo:UBERON_0004121 , obo:UBERON_0004732 , obo:UBERON_0010314 .

obo:VO_0000091 a rdfs:Class ;
  rdfs:label "ProQuad" ;
  rdfs:comment "A Measles-Mumps-Rubella-Vericella vaccine that is live and manufactured by Merck & Co, Inc. " ;
  rdfs:subClassOf obo:VO_0000737 .

obo:OVAE_0000386 a rdfs:Class ;
  rdfs:label "Hiberix-associated fever AE" ;
  rdfs:comment "A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000021 .

obo:OVAE_0000305 a rdfs:Class ;
  rdfs:label "Influenza Virus Vaccine H5N1-associated myalgia AE" ;
  rdfs:comment "A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000024 .

obo:OVAE_0000725 a rdfs:Class ;
  rdfs:label "Adacel-associated local swelling AE" ;
  rdfs:comment "A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an local swelling AE" ;
  rdfs:subClassOf obo:OAE_0001139 , obo:OVAE_0000988 .

obo:UBERON_0004119 a rdfs:Class ;
  rdfs:label "endoderm-derived structure" ;
  rdfs:comment "An anatomical structure that develops (entirely or partially) from the endoderm." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OVAE_0000504 a rdfs:Class ;
  rdfs:label "JE-Vax-associated abdominal pain AE" ;
  rdfs:comment "A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an abdominal pain AE" ;
  rdfs:subClassOf obo:OAE_0000402 , obo:OVAE_0000027 .

obo:OVAE_0000417 a rdfs:Class ;
  rdfs:label "Comvax-associated crying abnormal AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an crying abnormal AE" ;
  rdfs:subClassOf obo:OAE_0000393 , obo:OVAE_0000065 .

obo:VO_0000031 a rdfs:Class ;
  rdfs:label "MenHibrix"@en ;
  rdfs:comment "a vaccine for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups C and Y and Haemophilus influenzae type b. MENHIBRIX is approved for use in children 6 weeks of age through 18 months of age. " ;
  rdfs:subClassOf obo:VO_0000662 .

obo:OBI_0000319 a rdfs:Class ;
  rdfs:label "material to be added role"@en ;
  rdfs:comment "material to be added role is a protocol participant role realized by a material which is added into a material bearing the target of material addition role in a material addition process"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OVAE_0000536 a rdfs:Class ;
  rdfs:label "Menactra-associated crying abnormal AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an crying abnormal AE" ;
  rdfs:subClassOf obo:OAE_0000393 , obo:OVAE_0000029 .

obo:OAE_0000435 a rdfs:Class ;
  rdfs:label "muscle AE" ;
  rdfs:comment "a musculoskeletal system AE that occurs in muscle." ;
  rdfs:subClassOf obo:OAE_0000027 .

obo:OVAE_0000986 a rdfs:Class ;
  rdfs:label "ActHIB vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000072 .

obo:UBERON_0002037 a rdfs:Class ;
  rdfs:label "cerebellum" ;
  rdfs:comment "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." ;
  rdfs:subClassOf obo:UBERON_0002616 , obo:UBERON_0010314 .

obo:OAE_0000393 a rdfs:Class ;
  rdfs:label "crying abnormal AE" ;
  rdfs:comment "a behavior and neurological AE that has an outcome of abnormal crying in a patient" ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:OVAE_0000041 a rdfs:Class ;
  rdfs:label "RabAvert vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000118 .

obo:OVAE_0000770 a rdfs:Class ;
  rdfs:label "YF-Vax-associated myalgia AE" ;
  rdfs:comment "A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000055 .

obo:UBERON_0005290 a rdfs:Class ;
  rdfs:label "myelencephalon" ;
  rdfs:comment "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." ;
  rdfs:subClassOf obo:UBERON_0004733 .

obo:VO_0000910 a rdfs:Class ;
  rdfs:label "vaccine allergen" ;
  rdfs:comment "vaccine allergen is a material entity that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals who has been vaccinated with a vaccine." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OVAE_0000610 a rdfs:Class ;
  rdfs:label "Imovax Rabies-associated nausea AE" ;
  rdfs:comment "A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an nausea AE" ;
  rdfs:subClassOf obo:OAE_0000600 , obo:OVAE_0000022 .

obo:OVAE_0000457 a rdfs:Class ;
  rdfs:label "Recombivax HB-associated injection-site pruritus AE" ;
  rdfs:comment "A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site pruritus AE" ;
  rdfs:subClassOf obo:OAE_0000324 , obo:OVAE_0000042 .

obo:OVAE_0000330 a rdfs:Class ;
  rdfs:label "Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site rash AE" ;
  rdfs:comment "A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site rash AE" ;
  rdfs:subClassOf obo:OAE_0000325 , obo:OVAE_0000007 .

obo:OVAE_0000375 a rdfs:Class ;
  rdfs:label "Pentacel-associated fever AE" ;
  rdfs:comment "A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000036 .

obo:VO_0003022 a rdfs:Class ;
  rdfs:label "subcutaneous vaccination" ;
  rdfs:comment "vaccination process that occurs in the subcutaneous route" ;
  rdfs:subClassOf obo:VO_0000002 .

obo:OVAE_0000012 a rdfs:Class ;
  rdfs:label "Flucelvax vaccine adverse event" ;
  rdfs:comment "An influenza vaccine adverse event that is associated with the administration of Flucelvax." ;
  rdfs:subClassOf obo:OVAE_0000070 .

obo:OAE_0000644 a rdfs:Class ;
  rdfs:label "injection-site erythema AE" ;
  rdfs:comment "injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection" ;
  rdfs:subClassOf obo:OAE_0000645 .

obo:UBERON_0000489 a rdfs:Class ;
  rdfs:label "cavitated compound organ" ;
  rdfs:comment "Compound organ that contains one or more macroscopic anatomical spaces." ;
  rdfs:subClassOf obo:UBERON_0003103 .

obo:OVAE_0000121 a rdfs:Class ;
  rdfs:label "Yellow fever vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Yellow fever vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:UBERON_0005731 a rdfs:Class ;
  rdfs:label "fin field" ;
  rdfs:comment "A limb/fin field that has_potential_to_developmentally_contribute_to a paired fin bud." ;
  rdfs:subClassOf obo:UBERON_0005732 .

obo:VO_0000251 a rdfs:Class ;
  rdfs:label "pgp.LAMP-1 DNA vaccine plasmid"@en ;
  rdfs:comment "A DNA vaccine plasmid vector that has the plasmid label pgp.LAMP-1.  This plasmid has a CMV promoter and contains the human lysosomal-associated membrane protein-1 signal sequence." ;
  rdfs:subClassOf obo:VO_0000435 .

obo:UBERON_0000475 a rdfs:Class ;
  rdfs:label "organism subdivision" ;
  rdfs:comment "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:UBERON_0000925 a rdfs:Class ;
  rdfs:label "endoderm" ;
  rdfs:comment "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." ;
  rdfs:subClassOf obo:UBERON_0000923 .

obo:UBERON_0000108 a rdfs:Class ;
  rdfs:label "blastula stage" ;
  rdfs:comment "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." ;
  rdfs:subClassOf obo:UBERON_0000067 .

obo:OVAE_0000079 a rdfs:Class ;
  rdfs:label "Neisseria meningitidis vaccine adverse event"@en ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:OVAE_0000736 a rdfs:Class ;
  rdfs:label "Boostrix-associated headache AE" ;
  rdfs:comment "A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000063 .

obo:OVAE_0000558 a rdfs:Class ;
  rdfs:label "Menomune-A/C/Y/W-135-associated injection-site redness AE" ;
  rdfs:comment "A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000031 .

obo:UBERON_0000341 a rdfs:Class ;
  rdfs:label "throat" ;
  rdfs:comment "In anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the trachea and prevents inhalation of food or drink. The throat contains various blood vessels, various pharyngeal muscles, the trachea (windpipe) and the esophagus. The hyoid bone and the clavicle are the only bones located in the throat of mammals. It is sometimes considered a synonym for fauces. [WP,unvetted]." ;
  rdfs:subClassOf obo:UBERON_0034929 .

<https://w3id.org/linkml/Any> a rdfs:Class ;
  rdfs:comment "An unconstrained type or object" .

obo:OVAE_0000052 a rdfs:Class ;
  rdfs:label "Vaqta vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000109 .

obo:IAO_0000005 a rdfs:Class ;
  rdfs:label "objective specification"@en ;
  rdfs:comment "a directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OVAE_0000435 a rdfs:Class ;
  rdfs:label "Vaqta-associated fever AE" ;
  rdfs:comment "A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000052 .

obo:OVAE_0000680 a rdfs:Class ;
  rdfs:label "Decavac-associated pain AE" ;
  rdfs:comment "A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an pain AE" ;
  rdfs:subClassOf obo:OAE_0000374 , obo:OVAE_0000067 .

obo:OAE_0000476 a rdfs:Class ;
  rdfs:label "immune system AE" ;
  rdfs:comment "an AE that occurs in immune system." ;
  rdfs:subClassOf obo:OAE_0000001 .

obo:OAE_0000400 a rdfs:Class ;
  rdfs:label "syncope AE" ;
  rdfs:comment "a sensory capability AE that has an outcome of loss of consciousness, fainting" ;
  rdfs:subClassOf obo:OAE_0000582 .

obo:UBERON_0006240 a rdfs:Class ;
  rdfs:label "future forebrain" ;
  rdfs:comment "A presumptive structure that has the potential to develop into a forebrain." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OVAE_0000397 a rdfs:Class ;
  rdfs:label "PedvaxHIB-associated prolonged crying AE" ;
  rdfs:comment "A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an prolonged crying AE" ;
  rdfs:subClassOf obo:OAE_0000217 , obo:OVAE_0000035 .

obo:UBERON_0013232 a rdfs:Class ;
  rdfs:label "serous acinus" ;
  rdfs:comment "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells." ;
  rdfs:subClassOf obo:UBERON_0009842 , obo:UBERON_0011858 .

obo:OVAE_0000543 a rdfs:Class ;
  rdfs:label "Menactra-associated injection-site induration AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000029 .

obo:OVAE_0000063 a rdfs:Class ;
  rdfs:label "Boostrix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000102 .

obo:NCBITaxon_85007 a rdfs:Class ;
  rdfs:label "Corynebacterineae" ;
  rdfs:subClassOf obo:NCBITaxon_2 .

obo:OVAE_0000023 a rdfs:Class ;
  rdfs:label "Infanrix vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000102 .

obo:OAE_0000556 a rdfs:Class ;
  rdfs:label "edema AE" ;
  rdfs:comment "an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" ;
  rdfs:subClassOf obo:OAE_0000546 .

obo:VO_0001256 a rdfs:Class ;
  rdfs:label "polysaccharide of pathogen organism as vaccine component" ;
  rdfs:subClassOf obo:VO_0000000 .

obo:UBERON_0000076 a rdfs:Class ;
  rdfs:label "external ectoderm" ;
  rdfs:comment "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." ;
  rdfs:subClassOf obo:UBERON_0000490 , obo:UBERON_0005291 .

obo:NCBITaxon_35268 a rdfs:Class ;
  rdfs:label "Retro-transcribing viruses" ;
  rdfs:subClassOf obo:NCBITaxon_10239 .

obo:UBERON_0007530 a rdfs:Class ;
  rdfs:label "migrating mesenchyme population" ;
  rdfs:comment "Mesenchymal cells that are migrating." ;
  rdfs:subClassOf obo:UBERON_0003104 .

obo:UBERON_0007823 a rdfs:Class ;
  rdfs:label "appendage girdle region" ;
  rdfs:comment "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." ;
  rdfs:subClassOf obo:UBERON_0000475 .

obo:UBERON_0034944 a rdfs:Class ;
  rdfs:label "zone of organ" ;
  rdfs:subClassOf obo:UBERON_0000064 .

obo:OVAE_0000113 a rdfs:Class ;
  rdfs:label "Japanese encephalitis virus vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Japanese encephalitis virus vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:OVAE_0000110 a rdfs:Class ;
  rdfs:label "Hepatitis A&B vaccine adverse event" ;
  rdfs:comment "a viral vaccine adverse event that is associated with administration of Hepatitis A&B vaccine" ;
  rdfs:subClassOf obo:OVAE_0000002 .

obo:OVAE_0000763 a rdfs:Class ;
  rdfs:label "Typhim Vi-associated fever AE" ;
  rdfs:comment "A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000051 .

obo:OVAE_0000364 a rdfs:Class ;
  rdfs:label "Pediarix-associated irritability AE" ;
  rdfs:comment "A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an irritability AE" ;
  rdfs:subClassOf obo:OAE_0001105 , obo:OVAE_0000034 .

obo:VO_0000489 a rdfs:Class ;
  rdfs:label "licensed human vaccine role"@en ;
  rdfs:comment "a licensed vaccine role that is bears in a licensed human vaccine." ;
  rdfs:subClassOf obo:VO_0000630 .

obo:OVAE_0000746 a rdfs:Class ;
  rdfs:label "Vivotif-associated abdominal pain AE" ;
  rdfs:comment "A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an abdominal pain AE" ;
  rdfs:subClassOf obo:OAE_0000402 , obo:OVAE_0000054 .

obo:OGG_0000000001 a rdfs:Class ;
  rdfs:label "genome"@en ;
  rdfs:comment "A genome is a material entity that represents the entirety of an organism's hereditary information. The genome includes both the genes and the non-coding sequences of the DNA and RNA." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:VO_0000001 a rdfs:Class ;
  rdfs:label "vaccine" ;
  rdfs:comment "A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine." ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:UBERON_0000073 a rdfs:Class ;
  rdfs:label "regional part of nervous system" ;
  rdfs:comment "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:VO_0003050 a rdfs:Class ;
  rdfs:label "vaccine conjugate role" ;
  rdfs:comment "role inheres in a material eneitity that union itself chemically with a relative weak vaccine antigen to form a new whole that can create an effective miinuogen. The " ;
  rdfs:subClassOf obo:VO_0000617 .

obo:NCBITaxon_40674 a rdfs:Class ;
  rdfs:label "Mammalia" ;
  rdfs:subClassOf obo:NCBITaxon_32524 .

obo:OVAE_0000569 a rdfs:Class ;
  rdfs:label "Pneumovax 23-associated injection-site induration AE" ;
  rdfs:comment "A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site induration AE" ;
  rdfs:subClassOf obo:OAE_0000323 , obo:OVAE_0000037 .

obo:UBERON_0009878 a rdfs:Class ;
  rdfs:label "mesopodial skeleton" ;
  rdfs:comment "The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton" ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0010712 , obo:UBERON_0010912 .

obo:NCBITaxon_10239 a rdfs:Class ;
  rdfs:label "Viruses" ;
  rdfs:subClassOf obo:OBI_0100026 .

obo:PATO_0000165 a rdfs:Class ;
  rdfs:label "time"@en ;
  rdfs:comment "A quality in which events occur in sequence."@en ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OVAE_0000595 a rdfs:Class ;
  rdfs:label "Prevnar 13-associated chills AE" ;
  rdfs:comment "A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an chills AE" ;
  rdfs:subClassOf obo:OAE_0000394 , obo:OVAE_0000039 .

obo:OAE_0000584 a rdfs:Class ;
  rdfs:label "hypersensitivity AE" ;
  rdfs:comment "Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal." ;
  rdfs:subClassOf obo:OAE_0000476 .

obo:VO_0000745 a rdfs:Class ;
  rdfs:label "Hepatitis A&B vaccine" ;
  rdfs:subClassOf obo:VO_0000609 .

obo:UBERON_0007282 a rdfs:Class ;
  rdfs:label "presumptive segmental plate" ;
  rdfs:comment "A presumptive structure that has the potential to develop into a presomitic mesoderm." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OVAE_0000627 a rdfs:Class ;
  rdfs:label "RabAvert-associated rash AE" ;
  rdfs:comment "A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000041 .

obo:OVAE_0000478 a rdfs:Class ;
  rdfs:label "Gardasil-associated injection-site pruritus AE" ;
  rdfs:comment "A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site pruritus AE" ;
  rdfs:subClassOf obo:OAE_0000324 , obo:OVAE_0000019 .

obo:OVAE_0000510 a rdfs:Class ;
  rdfs:label "ProQuad-associated fever AE" ;
  rdfs:comment "A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an fever AE" ;
  rdfs:subClassOf obo:OAE_0000361 , obo:OVAE_0000040 .

obo:OVAE_0000038 a rdfs:Class ;
  rdfs:label "Prevnar vaccine adverse event" ;
  rdfs:subClassOf obo:OVAE_0000078 .

obo:OVAE_0000406 a rdfs:Class ;
  rdfs:label "Comvax-associated injection-site tenderness AE" ;
  rdfs:comment "A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site tenderness AE" ;
  rdfs:subClassOf obo:OAE_0001547 , obo:OVAE_0000065 .

obo:VO_0000084 a rdfs:Class ;
  rdfs:label "Pentacel" ;
  rdfs:comment "Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine" ;
  rdfs:subClassOf obo:VO_0000744 .

obo:OVAE_0000221 a rdfs:Class ;
  rdfs:label "Flulaval-associated headache AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000013 .

obo:OVAE_0000651 a rdfs:Class ;
  rdfs:label "ACAM2000-associated malaise AE" ;
  rdfs:comment "A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000987 .

obo:UBERON_0007277 a rdfs:Class ;
  rdfs:label "presumptive hindbrain" ;
  rdfs:comment "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:OVAE_0000225 a rdfs:Class ;
  rdfs:label "Fluarix-associated decreased appetite AE" ;
  rdfs:comment "A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an decreased appetite AE" ;
  rdfs:subClassOf obo:OAE_0000396 , obo:OVAE_0000010 .

obo:OVAE_0000637 a rdfs:Class ;
  rdfs:label "RotaTeq-associated otitis media AE" ;
  rdfs:comment "A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an otitis media AE" ;
  rdfs:subClassOf obo:OAE_0000340 , obo:OVAE_0000044 .

obo:VO_0000044 a rdfs:Class ;
  rdfs:label "FluMist" ;
  rdfs:comment "Trade Name: FluMist" ;
  rdfs:subClassOf obo:VO_0000642 .

obo:OAE_0000385 a rdfs:Class ;
  rdfs:label "arthralgia AE" ;
  rdfs:comment "An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term \"arthralgia\" should only be used when the condition is non-inflammatory, and the term \"arthritis\" should be used when the condition is inflammatory." ;
  rdfs:subClassOf obo:OAE_0000442 .

obo:OVAE_0000446 a rdfs:Class ;
  rdfs:label "Engerix-B-associated injection-site muscular soreness AE" ;
  rdfs:comment "A Engerix-B vaccine adverse event that is associated with an administration of Engerix-B and displays an injection-site muscular soreness AE" ;
  rdfs:subClassOf obo:OAE_0001549 , obo:OVAE_0000008 .

obo:OAE_0001403 a rdfs:Class ;
  rdfs:label "sleep disorder AE" ;
  rdfs:comment "a behavior and neurological AE that results in irregular sleep patterns" ;
  rdfs:subClassOf obo:OAE_0000580 .

obo:UBERON_0005153 a rdfs:Class ;
  rdfs:label "epithelial bud" ;
  rdfs:comment "A bud is a protrusion that forms from an epithelial sheet by localized folding." ;
  rdfs:subClassOf obo:UBERON_0005157 .

obo:OGMS_0000061 a rdfs:Class ;
  rdfs:label "pathological bodily process" ;
  rdfs:comment "A bodily process that is clinically abnormal."@en ;
  rdfs:subClassOf obo:OGMS_0000060 .

obo:OAE_0001554 a rdfs:Class ;
  rdfs:label "restlessness AE"@en ;
  rdfs:comment "a psychiatric disorder AE that shows restlessness" ;
  rdfs:subClassOf obo:OAE_0001797 .

obo:UBERON_0010092 a rdfs:Class ;
  rdfs:label "future metencephalon" ;
  rdfs:comment "A developing anatomical structure that has the potential to develop into a metencephalon." ;
  rdfs:subClassOf obo:UBERON_0006598 .

obo:VO_0000665 a rdfs:Class ;
  rdfs:label "Japanese encephalitis virus vaccine" ;
  rdfs:comment "A viral vaccine that protects against infection with Japanese encephalitis virus." ;
  rdfs:subClassOf obo:VO_0000609 .

obo:OVAE_0000322 a rdfs:Class ;
  rdfs:label "Biothrax-associated fatigue AE" ;
  rdfs:comment "A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an fatigue AE" ;
  rdfs:subClassOf obo:OAE_0000034 , obo:OVAE_0000061 .

obo:UBERON_0001969 a rdfs:Class ;
  rdfs:label "blood plasma" ;
  rdfs:comment "The liquid component of blood, in which erythrocytes are suspended." ;
  rdfs:subClassOf obo:UBERON_0000179 .

obo:NCBITaxon_11158 a rdfs:Class ;
  rdfs:label "Paramyxoviridae" ;
  rdfs:subClassOf obo:NCBITaxon_11157 .

obo:NCBITaxon_2 a rdfs:Class ;
  rdfs:label "Bacteria" ;
  rdfs:subClassOf obo:OBI_0100026 .

obo:OVAE_0000714 a rdfs:Class ;
  rdfs:label "Tetanus Toxoid Absorbed-associated rash AE" ;
  rdfs:comment "A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an rash AE" ;
  rdfs:subClassOf obo:OAE_0000362 , obo:OVAE_0000048 .

obo:VO_0000940 a rdfs:Class ;
  rdfs:label "yeast protein cell culture residual in vaccine" ;
  rdfs:comment "a cell culture residual in vaccine that is yeast protein." ;
  rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000340 a rdfs:Class ;
  rdfs:label "intramuscular route" ;
  rdfs:comment "a route of administration that inject the material(such as vaccines, allergens) directly into a muscle." ;
  rdfs:subClassOf obo:VO_0000574 .

obo:UBERON_0000179 a rdfs:Class ;
  rdfs:label "haemolymphatic fluid" ;
  rdfs:comment "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." ;
  rdfs:subClassOf obo:UBERON_0000463 , obo:UBERON_0006314 .

obo:NCBITaxon_32524 a rdfs:Class ;
  rdfs:label "Amniota" ;
  rdfs:subClassOf obo:NCBITaxon_117571 .

obo:NCBITaxon_1392 a rdfs:Class ;
  rdfs:label "Bacillus anthracis" ;
  rdfs:subClassOf obo:NCBITaxon_1385 .

obo:UBERON_0000065 a rdfs:Class ;
  rdfs:label "respiratory tract" ;
  rdfs:comment "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts" ;
  rdfs:subClassOf obo:UBERON_0001005 , obo:UBERON_0004119 .

obo:NCBITaxon_12080 a rdfs:Class ;
  rdfs:label "Human poliovirus 1" ;
  rdfs:subClassOf obo:NCBITaxon_138950 .

obo:UBERON_0000062 a rdfs:Class ;
  rdfs:label "organ" ;
  rdfs:comment "Anatomical structure that performs a specific function or group of functions [WP]." ;
  rdfs:subClassOf obo:UBERON_0010000 .

obo:OVAE_0000733 a rdfs:Class ;
  rdfs:label "Boostrix-associated injection-site redness AE" ;
  rdfs:comment "A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site redness AE" ;
  rdfs:subClassOf obo:OAE_0001546 , obo:OVAE_0000063 .

obo:OVAE_0000241 a rdfs:Class ;
  rdfs:label "Flublok-associated myalgia AE" ;
  rdfs:comment "A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a myalgia AE" ;
  rdfs:subClassOf obo:OAE_0000375 , obo:OVAE_0000009 .

obo:OVAE_0000551 a rdfs:Class ;
  rdfs:label "Menactra-associated malaise AE" ;
  rdfs:comment "A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an malaise AE" ;
  rdfs:subClassOf obo:OAE_0000390 , obo:OVAE_0000029 .

obo:NCBITaxon_10292 a rdfs:Class ;
  rdfs:label "Herpesviridae" ;
  rdfs:subClassOf obo:NCBITaxon_35237 .

obo:UBERON_0003077 a rdfs:Class ;
  rdfs:label "paraxial mesoderm" ;
  rdfs:comment "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]" ;
  rdfs:subClassOf obo:UBERON_0004120 , obo:UBERON_0005291 , obo:UBERON_0007524 , obo:UBERON_0015212 .

obo:OVAE_0000521 a rdfs:Class ;
  rdfs:label "Menveo-associated headache AE" ;
  rdfs:comment "A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an headache AE" ;
  rdfs:subClassOf obo:OAE_0000377 , obo:OVAE_0000032 .

obo:UBERON_0007844 a rdfs:Class ;
  rdfs:label "cartilage element" ;
  rdfs:comment "Skeletal element that is composed of cartilage tissue and may be permanent or transient." ;
  rdfs:subClassOf obo:UBERON_0004765 .

obo:OVAE_0000102 a rdfs:Class ;
  rdfs:label "Diphtheria-Tetanus-Pertussis vaccine adverse event" ;
  rdfs:comment "a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis vaccine" ;
  rdfs:subClassOf obo:OVAE_0000001 .

obo:VO_0000731 a rdfs:Class ;
  rdfs:label "Measles-Mumps-Rubella vaccine" ;
  rdfs:comment "A Measles-Mumps vaccine that also protects against infection with  Rubella virus." ;
  rdfs:subClassOf obo:VO_0000736 .

obo:BFO_0000055 a rdf:Property ;
  rdfs:label "realizes"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000067 a rdf:Property ;
  rdfs:label "contains process"@en ;
  rdfs:comment "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000070 a rdf:Property ;
  rdfs:label "specifically depends on at all times"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000169 .

obo:BFO_0000179 a rdf:Property ;
  rdfs:label "BFO OWL specification label" ;
  rdfs:comment "Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification."@en ;
  rdfs:range xsd:string .

obo:BFO_0000180 a rdf:Property ;
  rdfs:label "BFO CLIF specification label" ;
  rdfs:comment "Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2"@en ;
  rdfs:range xsd:string .

obo:BSPO_0000124 a rdf:Property ;
  rdfs:label "in_proximal_side_of" ;
  rdfs:comment "X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:BSPO_0000125 a rdf:Property ;
  rdfs:label "in_distal_side_of" ;
  rdfs:comment "X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:IAO_0000111 a rdf:Property ;
  rdfs:label "editor preferred term" ;
  rdfs:comment "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000112 a rdf:Property ;
  rdfs:label "example of usage" ;
  rdfs:comment "A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not"@en ;
  rdfs:range xsd:string .

obo:IAO_0000114 a rdf:Property ;
  rdfs:label "has curation status" ;
  rdfs:range xsd:string .

obo:IAO_0000115 a rdf:Property ;
  rdfs:label "textual definition" ;
  rdfs:comment "The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en ;
  rdfs:range xsd:string .

obo:IAO_0000116 a rdf:Property ;
  rdfs:label "editor note" ;
  rdfs:comment "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
  rdfs:range xsd:string .

obo:IAO_0000117 a rdf:Property ;
  rdfs:label "term editor" ;
  rdfs:comment "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
  rdfs:range xsd:string .

obo:IAO_0000118 a rdf:Property ;
  rdfs:label "alternative term" ;
  rdfs:comment "An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000119 a rdf:Property ;
  rdfs:label "definition source" ;
  rdfs:comment "formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
  rdfs:range xsd:string .

obo:IAO_0000232 a rdf:Property ;
  rdfs:label "curator notes" ;
  rdfs:comment "An administrative note of use for a curator but of no use for a user"@en ;
  rdfs:range xsd:string .

obo:IAO_0000412 a rdf:Property ;
  rdfs:label "imported from" ;
  rdfs:comment "For external terms/classes, the ontology from which the term was imported"@en ;
  rdfs:range xsd:string .

obo:IAO_0000424 a rdf:Property ;
  rdfs:label "expand expression to"@en ;
  rdfs:range xsd:string .

obo:IAO_0000425 a rdf:Property ;
  rdfs:label "expand assertion to"@en ;
  rdfs:range xsd:string .

obo:IAO_0000600 a rdf:Property ;
  rdfs:label "elucidation" ;
  rdfs:range xsd:string .

obo:IAO_0000601 a rdf:Property ;
  rdfs:label "has associated axiom(nl)" ;
  rdfs:range xsd:string .

obo:IAO_0000602 a rdf:Property ;
  rdfs:label "has associated axiom(fol)" ;
  rdfs:range xsd:string .

obo:OAE_0001849 a rdf:Property ;
  rdfs:label "Chinese translation"@en ;
  rdfs:comment "a chinese translation represents a chinese translation of the existing term." ;
  rdfs:range xsd:string .

obo:OAE_0003232 a rdf:Property ;
  rdfs:label "adverse event outcome"@en ;
  rdfs:comment "an annotation property that represents the label of an adverse event" ;
  rdfs:range xsd:string .

obo:OGG_0000000015 a rdf:Property ;
  rdfs:label "organism NCBITaxon ID"@en ;
  rdfs:comment "The NCBITaxon ontology ID of an organism." ;
  rdfs:range xsd:string .

obo:OVAE_0000057 a rdf:Property ;
  rdfs:label "has VAE occurrence" ;
  rdfs:comment "a data property that indicates a vaccinee having an occurrence of a specific VAE of a particular data value that is in the range of 0 and 1." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OVAE_0000058 a rdf:Property ;
  rdfs:label "occurs in population"@en ;
  rdfs:comment "an 'occurs in' relation that is a shortcut relation combining the 'occurs in' relation in an specific term which is part of a population." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000066 .

obo:OVAE_0000059 a rdf:Property ;
  rdfs:label "has age in year"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000056 a rdf:Property ;
  rdfs:label "participates in"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000059 a rdf:Property ;
  rdfs:label "concretizes"@en ;
  rdfs:comment "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000085 a rdf:Property ;
  rdfs:label "has function"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001900 a rdf:Property ;
  rdfs:label "temporal interpretation"@en ;
  rdfs:comment "An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002081 a rdf:Property ;
  rdfs:label "before or simultaneous with"@en ;
  rdfs:comment "Primitive instance level timing relation between events" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002082 a rdf:Property ;
  rdfs:label "simultaneous_with" ;
  rdfs:comment "Relation between occurrents, shares start and end boundaries." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002223 , obo:RO_0002229 , obo:RO_0002081 .

obo:RO_0002086 a rdf:Property ;
  rdfs:label "ends after"@en ;
  rdfs:comment "X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002090 a rdf:Property ;
  rdfs:label "immediately precedes"@en ;
  rdfs:comment "X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000063 .

obo:RO_0002092 a rdf:Property ;
  rdfs:label "happens during"@en ;
  rdfs:comment "X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002093 .

obo:RO_0002093 a rdf:Property ;
  rdfs:label "ends during"@en ;
  rdfs:comment "X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). "@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:RO_0002131 a rdf:Property ;
  rdfs:label "overlaps"@en ;
  rdfs:comment "x overlaps y if and only if there exists some z such that x has part z and z part of y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002158 a rdf:Property ;
  rdfs:label "homologous_to" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002161 a rdf:Property ;
  rdfs:label "never in taxon" ;
  rdfs:comment "x never in taxon T if and only if T is a class, and x does not instantiate the class expression \"in taxon some T\". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002172 .

obo:RO_0002172 a rdf:Property ;
  rdfs:label "taxonomic class assertion"@en ;
  rdfs:comment "An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon." ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002420 .

obo:RO_0002174 a rdf:Property ;
  rdfs:label "dubious_for_taxon" ;
  rdfs:comment "S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T." ;
  rdfs:range xsd:string .

obo:RO_0002175 a rdf:Property ;
  rdfs:label "present_in_taxon" ;
  rdfs:comment "S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S" ;
  rdfs:range xsd:string .

obo:RO_0002203 a rdf:Property ;
  rdfs:label "develops_into" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002387 .

obo:RO_0002258 a rdf:Property ;
  rdfs:label "developmentally preceded by" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002323 a rdf:Property ;
  rdfs:label "mereotopologically related to"@en ;
  rdfs:comment "A mereological relationship or a topological relationship" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002416 a rdf:Property ;
  rdfs:label "logical macro assertion"@en ;
  rdfs:comment "An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL." ;
  rdfs:range xsd:string .

obo:RO_0002420 a rdf:Property ;
  rdfs:label "logical macro assertion on a class"@en ;
  rdfs:comment "A logical macro assertion whose domain is an IRI for a class" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002416 .

obo:RO_0002421 a rdf:Property ;
  rdfs:label "logical macro assertion on a property"@en ;
  rdfs:comment "A logical macro assertion whose domain is an IRI for a property" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002416 .

obo:RO_0002422 a rdf:Property ;
  rdfs:label "logical macro assertion on an object property"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002421 .

obo:RO_0002423 a rdf:Property ;
  rdfs:label "logical macro assertion on an annotation property"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002421 .

obo:RO_0002507 a rdf:Property ;
  rdfs:label "has material contribution from" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002575 a rdf:Property ;
  rdfs:label "is direct form of" ;
  rdfs:comment "relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002422 .

obo:UBPROP_0000001 a rdf:Property ;
  rdfs:label "external_definition" ;
  rdfs:comment "An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class." ;
  rdfs:range xsd:string .

obo:UBPROP_0000002 a rdf:Property ;
  rdfs:label "axiom_lost_from_external_ontology" ;
  rdfs:comment "A textual description of an axiom loss in this ontology compared to an external ontology." ;
  rdfs:range xsd:string .

obo:UBPROP_0000003 a rdf:Property ;
  rdfs:label "homology_notes" ;
  rdfs:comment "Notes on the homology status of this class." ;
  rdfs:range xsd:string .

obo:UBPROP_0000005 a rdf:Property ;
  rdfs:label "external_comment" ;
  rdfs:comment "An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info." ;
  rdfs:range xsd:string .

obo:UBPROP_0000006 a rdf:Property ;
  rdfs:label "implements_design_pattern" ;
  rdfs:range xsd:string .

obo:UBPROP_0000007 a rdf:Property ;
  rdfs:label "has_relational_adjective" ;
  rdfs:range xsd:string .

obo:UBPROP_0000008 a rdf:Property ;
  rdfs:label "taxon_notes" ;
  rdfs:comment "Notes on the how instances of this class vary across species." ;
  rdfs:range xsd:string .

obo:UBPROP_0000009 a rdf:Property ;
  rdfs:label "function_notes" ;
  rdfs:comment "Notes on the evolved function of instances of this class." ;
  rdfs:range xsd:string .

obo:UBPROP_0000010 a rdf:Property ;
  rdfs:label "structure_notes" ;
  rdfs:comment "Notes on the structure, composition or histology of instances of this class." ;
  rdfs:range xsd:string .

obo:UBPROP_0000011 a rdf:Property ;
  rdfs:label "development_notes" ;
  rdfs:comment "Notes on the ontogenic development of instances of this class." ;
  rdfs:range xsd:string .

obo:UBPROP_0000012 a rdf:Property ;
  rdfs:label "external_ontology_notes" ;
  rdfs:comment "Notes on how similar or equivalent classes are represented in other ontologies." ;
  rdfs:range xsd:string .

obo:UBPROP_0000013 a rdf:Property ;
  rdfs:label "terminology_notes" ;
  rdfs:comment "Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy." ;
  rdfs:range xsd:string .

obo:UBPROP_0000100 a rdf:Property ;
  rdfs:label "is count of" ;
  rdfs:range xsd:string .

obo:UBPROP_0000101 a rdf:Property ;
  rdfs:label "preceding element is" ;
  rdfs:comment "A property used in conjunction with repeated_element_number to indicate an axis and directionality along that axis. If P preceding_element_is R, and P is_count_of S, and X P N, and X' P N+1, then it follows that every X R some X', and the class expression [S and R some X' and inv(R) some X] is empty (i.e. X is followed by X', with no intermediates)" ;
  rdfs:range xsd:string .

obo:UBPROP_0000105 a rdf:Property ;
  rdfs:label "phalanx number" ;
  rdfs:comment "x phalanx_number N if and only if (i) x is a phalanx, and (ii) x is phalanx number N in a series of phalanges repeated along an prixomo-distal axis, with phalanx_number 1 being the proximalmost phalanx. Note that in humans, the distalmost phalanx has phlanax_number 3, except in ray_number 1, where the distalmost has phalanx_number 2" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/ncbitaxon#has_rank> a rdf:Property ;
  rdfs:label "has_rank" ;
  rdfs:comment "A metadata relation between a class and its taxonomic rank (eg species, family)" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/ro/subsets#ro-eco> a rdf:Property ;
  rdfs:label "eco subset" ;
  rdfs:range xsd:string .

obo:role_of a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/uberon/core#cumbo> a rdf:Property ;
  rdfs:comment "CUMBO" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#developmental_classification> a rdf:Property ;
  rdfs:comment "developmental_classification" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#early_development> a rdf:Property ;
  rdfs:comment "A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes." ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#efo_slim> a rdf:Property ;
  rdfs:comment "EFO slim" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#emapa_ehdaa2> a rdf:Property ;
  rdfs:comment "derived from the union of EHDAA2 and EMAPA - still to be checked" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#functional_classification> a rdf:Property ;
  rdfs:comment "functional_classification" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#grouping_class> a rdf:Property ;
  rdfs:comment "Subset consisting of classes creating for grouping purposes" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#homology_grouping> a rdf:Property ;
  rdfs:comment "A grouping class that depends on an assumption of homology between subclasses" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#in_central_side_of> a rdf:Property ;
  rdfs:label "in_central_side_of" ;
  rdfs:comment "X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides." ;
  rdfs:seeAlso obo:BSPO_0000059 , <https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern> ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

<http://purl.obolibrary.org/obo/uberon/core#inconsistent_with_fma> a rdf:Property ;
  rdfs:comment "classes that have some inconsistency with FMA" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#major_organ> a rdf:Property ;
  rdfs:comment "somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord,  peripheral nerves, kidneys, ureters, bladder, urethra, gonads" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#non_informative> a rdf:Property ;
  rdfs:comment "abstract class brought in to group ontology classes but not informative" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#organ_slim> a rdf:Property ;
  rdfs:comment "organs, excluding individual muscles and skeletal elements" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#pheno_slim> a rdf:Property ;
  rdfs:comment "Phenotype slim" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to> a rdf:Property ;
  rdfs:label "transitively anteriorly connected to" ;
  rdfs:comment "." ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to> a rdf:Property ;
  rdfs:label "transitively_connected to" ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/uberon/core#transitively_distally_connected_to> a rdf:Property ;
  rdfs:label "transitively distally connected to" ;
  rdfs:comment "." ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to> a rdf:Property ;
  rdfs:label "transitively proximally connected to" ;
  rdfs:comment "." ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://purl.obolibrary.org/obo/uberon/core#uberon_slim> a rdf:Property ;
  rdfs:comment "Uberon slim - subset that excludes obscure terms and deep compositional terms" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#upper_level> a rdf:Property ;
  rdfs:comment "abstract upper-level terms not directly useful for analysis" ;
  rdfs:range xsd:string .

<http://purl.obolibrary.org/obo/uberon/core#vertebrate_core> a rdf:Property ;
  rdfs:comment "core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO" ;
  rdfs:range xsd:string .

<http://xmlns.com/foaf/0.1/depicted_by> a rdf:Property ;
  rdfs:label "depicted_by" ;
  rdfs:range xsd:string .

obo:VO_0000299 a rdfs:Class ;
  rdfs:label "company" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:VO_0000607 a obo:VO_0000299 ;
  rdfs:label "Intercell Biomedical" .

obo:VO_0000686 a obo:VO_0000299 ;
  rdfs:label "Acambis, Inc" .

obo:VO_0000687 a obo:VO_0000299 ;
  rdfs:label "Berna Biotech, Ltd" .

obo:VO_0000688 a obo:VO_0000299 ;
  rdfs:label "BioPort Corp" .

obo:VO_0000689 a obo:VO_0000299 ;
  rdfs:label "CSL Limited" .

obo:VO_0000690 a obo:VO_0000299 ;
  rdfs:label "GlaxoSmithKline Biologicals"@en .

obo:VO_0000692 a obo:VO_0000299 ;
  rdfs:label "ID Biomedical Corp of Quebec" .

obo:VO_0000693 a obo:VO_0000299 ;
  rdfs:label "Massachusetts Public Health Biologic Lab" .

obo:VO_0000694 a obo:VO_0000299 ;
  rdfs:label "MedImmune Vaccines, Inc" .

obo:VO_0000695 a obo:VO_0000299 ;
  rdfs:label "Merck & Co, Inc" .

obo:VO_0000696 a obo:VO_0000299 ;
  rdfs:label "Novartis Vaccines and Diagnostics" .

obo:VO_0000698 a obo:VO_0000299 ;
  rdfs:label "Research Foundation for Microbial Diseases of Osaka University" .

obo:VO_0000699 a obo:VO_0000299 ;
  rdfs:label "Sanofi Pasteur Limited" .

obo:VO_0000700 a obo:VO_0000299 ;
  rdfs:label "Sanofi Pasteur, Inc" .

obo:VO_0000701 a obo:VO_0000299 ;
  rdfs:label "Wyeth Pharmaceuticals Inc" .

obo:VO_0000703 a obo:VO_0000299 ;
  rdfs:label "Sanofi Pasteur, SA" .

obo:VO_0000896 a obo:VO_0000299 ;
  rdfs:label "Merck Frosst" .

obo:VO_0000971 a obo:VO_0000299 ;
  rdfs:label "Novartis" .
