PREFIX obo: <http://purl.obolibrary.org/obo/>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

obo:OBI_0200056 a rdfs:Class ;
  rdfs:label "moving average"@en ;
  rdfs:comment "A moving average is a data transformation in which center calculations, usually mean calculations, are performed on values within a sliding window across the input data set."@en ;
  rdfs:subClassOf obo:OBI_0200170 .

obo:OBI_0000299 a rdf:Property ;
  rdfs:label "has specified output"@en ;
  rdfs:comment "The inverse property of is specified output of" ;
  rdfs:domain obo:COB_0000035 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:OBI_0001950 a rdf:Property ;
  rdfs:label "has performer"@en ;
  rdfs:comment "A relation between a planned process and a continuant where the continuant can be a person, organization or device (such as a robot controlled by software workflow management system) that performs the planned process."@en ;
  rdfs:domain obo:COB_0000035 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:BFO_0000055 a rdf:Property ;
  rdfs:label "realizes"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process"@en ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000017 .

obo:OBI_0000417 a rdf:Property ;
  rdfs:label "achieves_planned_objective" ;
  rdfs:comment "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process."@en ;
  rdfs:domain obo:COB_0000035 ;
  rdfs:range obo:IAO_0000005 .

obo:RO_0002233 a rdf:Property ;
  rdfs:label "has input"@en ;
  rdfs:comment "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000293 a rdf:Property ;
  rdfs:label "has specified input"@en ;
  rdfs:comment "The inverse property of is specified input of" ;
  rdfs:domain obo:COB_0000035 ;
  rdfs:range obo:IAO_0000027 , <https://w3id.org/linkml/Any> , obo:OBI_0000660 , obo:OBI_0000023 , obo:OBI_0000118 , obo:OBI_0000648 ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:OBI_0000681 a rdfs:Class ;
  rdfs:label "separation into different composition objective" ;
  rdfs:comment "A material separation objective aiming to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities)."@en ;
  rdfs:subClassOf obo:OBI_0000639 .

obo:OBI_0000833 a rdf:Property ;
  rdfs:label "objective_achieved_by" ;
  rdfs:comment "This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process."@en ;
  rdfs:domain obo:IAO_0000005 ;
  rdfs:range obo:COB_0000035 .

obo:OBI_0001938 a rdf:Property ;
  rdfs:label "has value specification" ;
  rdfs:comment "A relation between an information content entity and a value specification that specifies its value."@en ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range obo:OBI_0001933 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:IAO_0000136 a rdf:Property ;
  rdfs:label "is about"@en ;
  rdfs:comment "A (currently) primitive relation that relates an information artifact to an entity."@en ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0000219 a rdf:Property ;
  rdfs:label "denotes"@en ;
  rdfs:comment "A primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically"@en ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> , obo:OBI_0000066 , obo:COB_0000022 , obo:OBI_0001636 , obo:OBI_0000973 , obo:OBI_0100051 , obo:SO_0000353 ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:GO_0110165 a rdfs:Class ;
  rdfs:label "cellular anatomical entity" ;
  rdfs:comment "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." ;
  rdfs:subClassOf obo:GO_0005575 , obo:UBERON_0000465 .

obo:BFO_0000051 a rdf:Property ;
  rdfs:label "has part"@en ;
  rdfs:comment "a core relation that holds between a whole and its part"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_1110119 a rdf:Property ;
  rdfs:label "bound_to" ;
  rdfs:comment "A relationship between two material entities that form a complex based on a selective, non-covalent interaction."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:COB_0000801 a rdf:Property ;
  rdfs:label "has number of atomic nuclei"@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000647 a rdf:Property ;
  rdfs:label "has_supplier" ;
  rdfs:comment "A relation between a material entity and an organisation or person who owned or has license to the material entity and there was a legal transfer of ownership or licensing of the material entity to the current owner."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range xsd:string .

obo:OBI_0000304 a rdf:Property ;
  rdfs:label "is_manufactured_by"@en ;
  rdfs:comment "c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the \"Manufacturer Role\", and those people/and or machines were members or of directed by the organization to do this."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:OBI_0000835 .

obo:OBI_0001637 a rdf:Property ;
  rdfs:label "has disposition to bind" ;
  rdfs:comment "A relationship between two material entitites that each have disposition to form a complex with the other."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 .

obo:OBI_0000161 a rdfs:Class ;
  rdfs:label "crossover population role"@en ;
  rdfs:comment "a role realized when a participant serves as reference to itself"@en ;
  rdfs:subClassOf obo:OBI_0000220 .

obo:BFO_0000054 a rdf:Property ;
  rdfs:label "realized in"@en ;
  rdfs:range obo:OBI_0000471 , obo:COB_0000035 , obo:OBI_0000070 , obo:OBI_0000066 , obo:OBI_1110021 , obo:OBI_0600014 , obo:GO_0019882 , obo:OBI_0000685 , obo:OBI_0001503 , obo:OBI_1110011 , obo:GO_0006955 , <https://w3id.org/linkml/Any> , obo:OBI_0000415 , obo:OBI_0000818 , obo:OBI_0001007 , obo:OBI_0000457 , obo:OBI_0600064 , obo:GO_0002250 , obo:OGMS_0000063 , obo:OBI_0000274 , obo:GO_0008150 , obo:OBI_0302886 , obo:OBI_1110014 .

obo:GO_0035397 a rdfs:Class ;
  rdfs:label "helper T cell enhancement of adaptive immune response" ;
  rdfs:comment "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell." ;
  rdfs:subClassOf obo:GO_0002250 .

obo:OBI_0600013 a rdfs:Class ;
  rdfs:label "information acquisition"@en ;
  rdfs:comment "An acquisition in which possession of information is gained."@en ;
  rdfs:subClassOf obo:OBI_0600008 .

obo:OBI_2100037 a rdfs:Class ;
  rdfs:label "folic acids assay" ;
  rdfs:comment "An analyte assay that measures the abundance of folic acids"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001623 a rdfs:Class ;
  rdfs:label "organism species detection objective"@en ;
  rdfs:comment "A biological feature identification objective to identify the organism species in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0003812 a rdfs:Class ;
  rdfs:label "estrous cycle duration assay" ;
  rdfs:comment "An estrous cycle assay based on tissue morphology that determines the average length of a full estrous cycle observed in a defined time."@en ;
  rdfs:subClassOf obo:OBI_0003766 .

obo:OBI_0000891 a rdfs:Class ;
  rdfs:label "cell proliferation assay" ;
  rdfs:comment "A cytometry assay which measures the degreee to which input cells are replicating."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0600044 a rdfs:Class ;
  rdfs:label "lavage"@en ;
  rdfs:comment "A protocol application to separate cells and/or cellular secretions from an anatomical space by the introduction and removal of fluid"@en ;
  rdfs:subClassOf obo:OBI_0600005 , obo:OBI_0600014 .

obo:OBI_0002620 a rdfs:Class ;
  rdfs:label "random mutagenesis" ;
  rdfs:comment "An induced mutation that produces a random mutation, either by introducing the organism to mutagens, or through a process such as error-prone PCR."@en ;
  rdfs:subClassOf obo:OBI_0001154 .

obo:OBI_0000595 a rdfs:Class ;
  rdfs:label "pulsed amperometric detector" ;
  rdfs:comment "A chromatography detector as used by high-performance anion exchange chromatography that provides sensitive and specific detection of carbohydrates. Pulsed Electrochemical Detection (PED) allows simple, sensitive, and direct detection of numerous polar aliphatic compounds, especially carbohydrates. This technique exploits the electrocatalytic activity of noble metal electrode surfaces to oxidize various polar functional groups. In PED, multi-step potential-time waveforms at Au and Pt electrodes realize amperometric/coulometric detection while maintaining uniform and reproducible electrode activity. The response mechanisms in PED are dominated by the surface properties of the electrode, and, as a consequence, members of each chemical class of compounds produce virtually identical voltammetric responses. Thus, the full potential is realized when combined with high performance liquid chromatography (HPLC)."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0000312 a rdf:Property ;
  rdfs:label "is specified output of"@en ;
  rdfs:comment "A relation between a completely executed planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
  rdfs:range obo:COB_0000035 ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:RO_0002215 a rdf:Property ;
  rdfs:label "capable of"@en ;
  rdfs:comment "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process." ;
  rdfs:range obo:BFO_0000015 .

obo:RO_0000085 a rdf:Property ;
  rdfs:label "has function"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0001803 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-7 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-7 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001587 .

obo:OBI_0001013 a rdfs:Class ;
  rdfs:label "kethoxal structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at nucleotide resolution scale using kethoxal as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001359 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-8 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-8 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001218 .

obo:OBI_0003839 a rdfs:Class ;
  rdfs:label "body mass assay" ;
  rdfs:comment "A mass measurement assay with evaluant an individual organism."@en ;
  rdfs:subClassOf obo:OBI_0000445 .

obo:OBI_0001038 a rdfs:Class ;
  rdfs:label "Ruthenium structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using Rhutenium as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:NCBITaxon_117571 a rdfs:Class ;
  rdfs:label "Euteleostomi" ;
  rdfs:subClassOf obo:NCBITaxon_7742 .

obo:GO_0035746 a rdfs:Class ;
  rdfs:label "granzyme A production" ;
  rdfs:comment "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0000547 a rdfs:Class ;
  rdfs:label "evaporative light scattering detector" ;
  rdfs:comment "The evaporative light scattering detector, as its name implies, utilizes a spray that continuously atomizes the column eluent into small droplets. These droplets are allowed to evaporate, leaving the solutes as fine particulate matter suspended in the atomizing gas."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0000916 a rdfs:Class ;
  rdfs:label "flow cytometry assay" ;
  rdfs:comment "A cytometry assay in which an input cell population is put in solution, is passed by a laser, and optical sensors are used to detect scattering of the laser light and/or fluorescence of specific markers to count and characterize the particles in solution."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:PR_000013429 a rdfs:Class ;
  rdfs:label "parathyroid hormone" ;
  rdfs:comment "A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0400034 a rdfs:Class ;
  rdfs:label "dye laser" ;
  rdfs:comment "A dye laser is a laser in which the lasing medium is a fluorescent dye, usually dissolved in an organic solvent such as ethanol or ethylene glycol. The particular dye used determines the wavelengths the laser can emit. The laser medium is places between two parallel mirrors for light emission amplification."@en ;
  rdfs:subClassOf obo:OBI_0400064 .

obo:OBI_0001132 a rdfs:Class ;
  rdfs:label "capillary electrophoresis instrument" ;
  rdfs:comment "An electrophoresis system that is used to separate ionic species by their charge and frictional forces and mass."@en ;
  rdfs:subClassOf obo:OBI_0001053 .

obo:OBI_0003216 a rdfs:Class ;
  rdfs:label "testosterone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of testosterone"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000094 a rdfs:Class ;
  rdfs:label "obsolete material processing" ;
  rdfs:comment "A planned process which results in physical changes in a specified input material"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001092 a rdfs:Class ;
  rdfs:label "computer cluster" ;
  rdfs:comment "A group of linked computers, working together closely so that in many respects they form a single computer."@en ;
  rdfs:subClassOf obo:OBI_0400107 .

obo:OBI_0001268 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-12 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001391 .

obo:OBI_0001926 a rdfs:Class ;
  rdfs:label "microRNA profiling assay" ;
  rdfs:comment "A transcription profiling assay that quantifies the microRNA species within a biological sample."@en ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_0002775 a rdfs:Class ;
  rdfs:label "platelet-poor plasma preparation process"@en ;
  rdfs:comment "A material component separation process in which (1) whole blood is first centrifuged to separate red blood cells from blood plasma, which forms the supernatant, and (2) the blood plasma is then centrifuged to separate platelets from the plasm."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0001184 a rdfs:Class ;
  rdfs:label "epitope protection experiment" ;
  rdfs:comment "An efficacy of epitope intervention experiment that tests the efficacy of inducing an immune epitope response to prevent disease in a host."@en ;
  rdfs:subClassOf obo:OBI_0001178 .

obo:OBI_0001006 a rdfs:Class ;
  rdfs:label "CMCT structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay which uses CMCT as reagent and chemical probe to generate data and information at nucleotide resolution scale contributing to the determination of nucleic acid secondary structure"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:PR_000029971 a rdfs:Class ;
  rdfs:label "creatine kinase" ;
  rdfs:comment "A protein that contains a single ATP:guanido phosphotransferase N-terminal domain (Pfam:PF02807) followed by a single ATP:guanido phosphotransferase C-terminal catalytic domain (Pfam:PF00217)." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0400023 a rdfs:Class ;
  rdfs:label "CYFlow ML" ;
  rdfs:comment "A CyFlow_ML is a flow_cytometer_analyser manufactured by Partec. It is a digital machine which uses 4 light sources: triple laser configurations including new powerful 200mW@488nm blue solid state laser + 100W UV lamp for highest resolution DNA analysis, and can collect 16 optical parameters: FSC1, FSC2, SSC, FL1-FL13. Ultracompact high end desktop multilaser Flow Cytometer for all applications in cell analysis and absolute counting."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0002050 a rdfs:Class ;
  rdfs:label "3D molecular structure determination assay of a MHC:ligand complex" ;
  rdfs:comment "A 3D structure determination of bound molecular complex assay that characterizes the 3-dimensional structure of a MHC:ligand complex."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001145 , obo:OBI_0002075 .

obo:CHEBI_17347 a rdfs:Class ;
  rdfs:label "testosterone" ;
  rdfs:comment "An androstanoid having 17β-hydroxy and 3-oxo groups, together with unsaturation at C-4‒C-5.." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0400142 a rdfs:Class ;
  rdfs:label "power supply" ;
  rdfs:comment "A power supply is an device or part of a device that permits the required application of a defined electrical charge to an instrument. The power supply may permit the defined application of a given amount of current for a defined length of time."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000268 a rdfs:Class ;
  rdfs:label "organism feature identification objective"@en ;
  rdfs:comment "Organism_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the level of the organism, e.g. height, weight, stage of development, stage of life cycle."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0003186 a rdfs:Class ;
  rdfs:label "immature neutrophil count assay" ;
  rdfs:comment "A neutrophil assay that measures the number of immature neutrophils in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003022 .

obo:OBI_0001125 a rdfs:Class ;
  rdfs:label "laser scanning confocal microscope" ;
  rdfs:comment "A confocal microscope that obtains high-resolution optical images with depth selectivity, in which a laser beam passes through a light source aperture and then is focused by an objective lens into a small (ideally diffraction limited) focal volume within or on the surface of a specimen."@en ;
  rdfs:subClassOf obo:OBI_0001079 .

obo:OBI_0002093 a rdfs:Class ;
  rdfs:label "5' RNA ligase mediated rapid amplification of cDNA ends"@en ;
  rdfs:comment "A 5' rapid amplification pf cDNA ends that uses RNA ligase to add an RNA adapter oligonucleotide to intact 5' mRNA ends, allowing the amplification of cDNA only from full-length, capped mRNA."@en ;
  rdfs:subClassOf obo:OBI_0002091 .

obo:OBI_0003255 a rdfs:Class ;
  rdfs:label "endotracheal tube aspirate microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of an endotracheal tube aspirate microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003254 .

obo:OBI_0003773 a rdfs:Class ;
  rdfs:label "neuron count assay" ;
  rdfs:comment "A cytometry assay that measures the number of neurons in a sample"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000655 a rdfs:Class ;
  rdfs:label "blood specimen" ;
  rdfs:comment "a material entity derived from a portion of blood collected from an organism"@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:RO_0001000 a rdf:Property ;
  rdfs:label "derives from"@en ;
  rdfs:comment "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity"@en ;
  rdfs:range <https://w3id.org/linkml/Any> , obo:CL_0000236 .

obo:RO_0000087 a rdf:Property ;
  rdfs:label "has role"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0003106 a rdfs:Class ;
  rdfs:label "sequential fluorescence in-situ hybridization assay" ;
  rdfs:comment "A fluorescence in-situ hybridization assay that involves ultra-resolution imaging of cell activity by targetting thousands of single molecules with fluorescent probes which find and hybridize with complementary DNA or RNA sequences in the tissue sample, thus enabling identification of those molecules directly in single cells with their spatial context preserved."@en ;
  rdfs:subClassOf obo:OBI_0003094 .

obo:OBI_0003888 a rdfs:Class ;
  rdfs:label "2A3 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 2-aminopyridine-3-carboxylic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001864 a rdfs:Class ;
  rdfs:label "RNA Annotation and Mapping of Promoters for the Analysis of Gene Expression assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that identifies transcription start sites (TSS), the quantification of their expression and the characterization of their transcripts using high throughput sequencing."@en ;
  rdfs:subClassOf obo:OBI_0001177 , obo:OBI_0001271 .

obo:OBI_0000815 a rdfs:Class ;
  rdfs:label "Berichrom(r) Antithrombin III (A) Kit" ;
  rdfs:comment "For the chromogenic determination of antithrombin III. Autoanalyzer method for undiluted samples. For the quantitative chromogenic determination of the functional activity of antithrombin III in plasma on autoanalyzers for the diagnosis of diminished AT III synthesis, increased consumption, and for monitoring substitution therapy. Berichrom(r) Antithrombin III (A) is used for the rapid determination of the physiologically active antithrombin III and permits the diagnosis of congenital and acquired antithrombin III deficiency, a condition frequently associated with an increased risk of thrombosis. Acquired antithrombin III deficiencies frequently occur due to consumption following major operations or due to disseminated intravascular coagulation (DIC) in cases of septicaemia, nephroses, liver parenchymal damage (hepatitis, drug intoxication, alcoholism) and estrogen-containing contraceptives. The test permits early detection of patients at increased risk for thrombosis. Kit contains: 6 x for 5.0 mL Thrombin (bovine), 3 x for 3.0 mL Substrate Reagent, 1 x 30.0 mL Buffer Solution"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:BFO_0000034 a rdfs:Class ;
  rdfs:label "function"@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:CHEBI_16737 a rdfs:Class ;
  rdfs:label "creatinine" ;
  rdfs:comment "A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001779 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-X-C motif) ligand 13 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-X-C motif) ligand 13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001065 a rdfs:Class ;
  rdfs:label "stereo microscope" ;
  rdfs:comment "An optical microscope that uses two separate optical paths with two objectives and two eyepieces to provide slightly different viewing angles to the left and right eyes."@en ;
  rdfs:subClassOf obo:OBI_0000940 .

obo:OBI_2100152 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0002399 a rdfs:Class ;
  rdfs:label "unilateral oophorectomy history" ;
  rdfs:comment "A gynecologic surgery history in which a woman has had a unilateral oophorectomy."@en ;
  rdfs:subClassOf obo:OBI_0002397 .

obo:OBI_0003333 a rdfs:Class ;
  rdfs:label "computed image data set" ;
  rdfs:comment "An image data set that is the output of an image data set analysis."@en ;
  rdfs:subClassOf obo:OBI_0003327 .

obo:OBI_0001292 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-15 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-15 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_2100246 a rdfs:Class ;
  rdfs:label "chem16 venous blood bilirubin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100018 .

obo:OBI_2100315 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood temperature assay" ;
  rdfs:comment "An assay that measures temperature in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0003028 a rdfs:Class ;
  rdfs:label "platelet assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of platelets"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000947 a rdfs:Class ;
  rdfs:label "service provider role" ;
  rdfs:comment "is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001995 a rdfs:Class ;
  rdfs:label "chromatography assay measuring the association constant [KA] of a B cell epitope:antibody complex" ;
  rdfs:comment "An analytical chromatography assay that measures the association constant [KA] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001630 , obo:OBI_0001719 .

obo:OBI_0000432 a rdfs:Class ;
  rdfs:label "polyacrylamide gel"@en ;
  rdfs:comment "a material entity resulting from the polymerization of acrylamide with TEMED in some buffer solution"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0001988 a rdfs:Class ;
  rdfs:label "feces" ;
  rdfs:comment "Portion of semisolid bodily waste discharged through the anus[MW,modified]." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OBI_2100264 a rdfs:Class ;
  rdfs:label "venous blood triglyceride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of triglyceride in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100029 .

obo:OBI_0002635 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific disease reduction resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that detects a decrease in disease after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0001190 , obo:OBI_0001507 , obo:OBI_0002676 .

obo:OBI_0003823 a rdfs:Class ;
  rdfs:label "neuron migration assay" ;
  rdfs:comment "A cell migration assay that measures migration of a neuron"@en ;
  rdfs:subClassOf obo:OBI_0003820 .

obo:BFO_0000017 a rdfs:Class ;
  rdfs:label "realizable entity"@en ;
  rdfs:subClassOf obo:COB_0000502 .

obo:OBI_0003358 a rdfs:Class ;
  rdfs:label "probabilistic brain region atlas image dataset" ;
  rdfs:comment "A brain atlas consisting of weighted values that respresent the probability that a voxel X is part of some brain component Y, typically derived from multiple image data sets."@en ;
  rdfs:subClassOf obo:OBI_0003357 .

obo:OBI_0200081 a rdfs:Class ;
  rdfs:label "sequence analysis objective"@en ;
  rdfs:comment "A sequence analysis objective is a data transformation objective which aims to analyse some ordered biological data for sequential patterns."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0000600 a rdfs:Class ;
  rdfs:label "JEOL NMR instrument" ;
  rdfs:comment "An NMR instrument that is manufactured by JEOL."@en ;
  rdfs:subClassOf obo:OBI_0000566 .

obo:OBI_0001319 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001414 .

obo:OBI_0002580 a rdfs:Class ;
  rdfs:label "aligned sequence data" ;
  rdfs:comment "The results of a sequence alignment."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0003067 a rdfs:Class ;
  rdfs:label "northing coordinate measurement datum" ;
  rdfs:comment "A one dimensional Cartesian spatial coordinate datum that is the northward component of a distance from a point on a map projection."@en ;
  rdfs:subClassOf obo:IAO_0000401 .

obo:OBI_0002126 a rdfs:Class ;
  rdfs:label "IHC-stained fixed tissue slide specimen" ;
  rdfs:comment "A fixed tissue slide specimen that is the output of immunohistochemistry slide staining."@en ;
  rdfs:subClassOf obo:OBIB_0000661 .

obo:OBI_0002660 a rdfs:Class ;
  rdfs:label "abdominal wall fat pad biopsy" ;
  rdfs:comment "A biopsy involving the collection of a small part of the abdominal wall fat pad."@en ;
  rdfs:subClassOf obo:OBI_0002650 .

obo:OBI_0000869 a rdfs:Class ;
  rdfs:label "polyA RNA extract" ;
  rdfs:comment "A RNA extract that is the output of an extraction process in which RNA molecules with poly A tail at its 3' end are purified."@en ;
  rdfs:subClassOf obo:OBI_0000880 .

obo:OBI_0000643 a rdf:Property ;
  rdfs:label "has grain" ;
  rdfs:comment "the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car."@en ;
  rdfs:range <https://w3id.org/linkml/Any> , obo:CL_0000010 , obo:CLO_0000019 , obo:COB_0000013 , obo:OBI_0001866 , obo:CHEBI_17234 , obo:CLO_0000018 , obo:CL_0000001 , obo:CLO_0000001 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:OBI_0600002 a rdfs:Class ;
  rdfs:label "tumor grading" ;
  rdfs:comment "An assay that determines the grade (severity/stage) of a tumor sample, used in cancer biology to describe abnormalities/qualities of tumor cells or tissues. Values can be described by terms from NCI Thesaurus."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100127 a rdfs:Class ;
  rdfs:label "inpatient profile venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a inpatient profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0002714 a rdfs:Class ;
  rdfs:label "insecticide resistance dose response by bottle assay" ;
  rdfs:comment "An insecticide resistance dose response assay that performs in a glass bottle coated with insecticides."@en ;
  rdfs:subClassOf obo:OBI_0002708 .

obo:OBI_0001645 a rdfs:Class ;
  rdfs:label "calorimetry assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A calorimetric binding assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001634 , obo:OBI_0001703 .

obo:OBI_0002544 a rdfs:Class ;
  rdfs:label "esophagogastric junction specimen" ;
  rdfs:comment "A specimen that is derived from the esophagogastric junction."@en ;
  rdfs:subClassOf obo:OBI_0003483 .

obo:OBI_0000355 a rdfs:Class ;
  rdfs:label "hypothesis-driven investigation"@en ;
  rdfs:comment "is an investigation with the goal to test one or more hypothesis"@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_0003703 a rdf:Property ;
  rdfs:label "has study design"@en ;
  rdfs:comment "A relation between an investigation and a study design in which part of the investigation is a study design execution that carries out the study design."@en ;
  rdfs:domain obo:OBI_0000066 ;
  rdfs:range obo:OBI_0500000 .

obo:OBI_0003146 a rdfs:Class ;
  rdfs:label "assay measuring quantitative binding of an antigen:antibody complex" ;
  rdfs:comment "An assay that detects the binding of an antigen with an antibody, and produces a quantitative measurement of the binding as an output."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110127 .

obo:OBI_0000821 a rdfs:Class ;
  rdfs:label "filled capsule" ;
  rdfs:comment "A pill in the form of a small rounded gelatinous container with medicine inside."@en ;
  rdfs:subClassOf obo:OBI_0000827 .

obo:OBI_0000575 a rdfs:Class ;
  rdfs:label "Bruker Ultrastabilized NMR magnet" ;
  rdfs:comment "An NMR magnet manufactured by Bruker for Ultra-High Field NMR, available from 750 MHz to 900 MHz, which provides reliable operation at reduced temperature and ambient pressure via being rigidly mounted and stabilized."@en ;
  rdfs:subClassOf obo:OBI_0000597 .

obo:UBERON_0000465 a rdfs:Class ;
  rdfs:label "material anatomical entity" ;
  rdfs:comment "Anatomical entity that has mass." ;
  rdfs:subClassOf obo:BFO_0000040 , obo:UBERON_0001062 .

obo:OBI_0001156 a rdfs:Class ;
  rdfs:label "age since planting measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since planting, the process of placing a plant in media (e.g. soil) to allow it to grow, which excludes sowing."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:IAO_0000413 a rdf:Property ;
  rdfs:label "is duration of"@en ;
  rdfs:comment "relates a process to a time-measurement-datum that represents the duration of the process"@en ;
  rdfs:domain obo:IAO_0000416 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:IAO_0000221 a rdf:Property ;
  rdfs:label "is quality measurement of"@en ;
  rdfs:comment "m is a quality measurement of q at t. When q is a quality, there is a measurement process p that has specified output m, a measurement datum, that is about q"@en ;
  rdfs:domain obo:IAO_0000109 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:OBI_0000026 a rdfs:Class ;
  rdfs:label "cytological stain role"@en ;
  rdfs:comment "A dye role that is realized when the stain is used to colour cells and or cellular components for the purposes of visualization"@en ;
  rdfs:subClassOf obo:OBI_0000250 .

obo:OBI_0003797 a rdfs:Class ;
  rdfs:label "bacterial neutralization assay" ;
  rdfs:comment "A pathogen neutralization assay measuring neutralization of bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003796 .

obo:OBI_0002157 a rdfs:Class ;
  rdfs:label "HBV surface antigen assay" ;
  rdfs:comment "An analyte assay that is meant to detect hepatitis B virus (HBV) surface antigens."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000970 a rdfs:Class ;
  rdfs:label "scalar score from composite inputs" ;
  rdfs:comment "A measurement datum which is the result of combining multiple datum. For example, a mean or summary score."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:IAO_0000004 a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0003517 a rdfs:Class ;
  rdfs:label "deep tendon reflex assessment" ;
  rdfs:comment "A functional assessment of an individual's muscle contraction when a muscle is triggered by a signal from a muscle spindle in response to a stimulus applied to a specific trigger point on the body."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0003840 a rdfs:Class ;
  rdfs:label "body mass change assay" ;
  rdfs:comment "A body mass assay that measures the change in body mass for a subject over a period of time."@en ;
  rdfs:subClassOf obo:OBI_0600026 .

obo:OBI_0200053 a rdfs:Class ;
  rdfs:label "expectation maximization"@en ;
  rdfs:comment "EM is a probabilistic algorithm used to estimate the maximum likelihood of parameters from existing data where the model involves unobserved latent variables. The input to this method is the data model for which the estimation is performed over and the output is an approximated probability function."@en ;
  rdfs:subClassOf obo:OBI_0200052 .

obo:OBI_0003459 a rdfs:Class ;
  rdfs:label "epitope protection from tumor challenge experiment based on survival" ;
  rdfs:comment "An epitope protection from tumor challenge experiment that determines the success of the epitope intervention based on increased survival of the host compared to controls."@en ;
  rdfs:subClassOf obo:OBI_0001183 .

obo:OBI_0003283 a rdfs:Class ;
  rdfs:label "pleural fluid microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a pleural fluid specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0500003 a rdfs:Class ;
  rdfs:label "cross over design" ;
  rdfs:comment "a repeated measure design which ensures that experimental units receive, in sequence, the treatment (or the control), and then, after a specified time interval (aka *wash-out periods*), switch to the control (or treatment). In this design, subjects (patients in human context) serve as their own controls, and randomization may be used to determine the ordering which a subject receives the treatment and control"@en ;
  rdfs:subClassOf obo:OBI_0500002 .

obo:OBI_0003704 a rdf:Property ;
  rdfs:label "is study design of"@en ;
  rdfs:comment "A relation between a study design and an investigation when part of the investigation is a study design execution that carries out the study design."@en ;
  rdfs:domain obo:OBI_0500000 ;
  rdfs:range obo:OBI_0000066 .

obo:OBI_0001233 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific granulocyte macrophage colony stimulating factor production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects granulocyte macrophage colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_2100225 a rdfs:Class ;
  rdfs:label "chem11 venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0003907 a rdfs:Class ;
  rdfs:label "count of multi-electrode plate electrodes detecting spike peak assay" ;
  rdfs:comment "A multi-electrode array assay that measures the average number of electrodes detecting a network spike, measured at the peak of a network spike."@en ;
  rdfs:subClassOf obo:OBI_0003901 .

obo:OBI_0003039 a rdfs:Class ;
  rdfs:label "feces microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a feces specimen."@en ;
  rdfs:subClassOf obo:OBI_0003237 , obo:OBI_0003498 .

obo:OBI_0000214 a rdfs:Class ;
  rdfs:label "negative reference substance role"@en ;
  rdfs:comment "a reference role in which the characteristics or responses elicited by the substance playing the reference substance role are used to establish a \"no effect\" response"@en ;
  rdfs:subClassOf obo:OBI_0000025 .

obo:RO_0000052 a rdf:Property ;
  rdfs:label "characteristic of"@en ;
  rdfs:comment "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence."@en ;
  rdfs:range <https://w3id.org/linkml/Any> , obo:COB_0000022 .

obo:OBI_0003828 a rdfs:Class ;
  rdfs:label "velocity measurement assay" ;
  rdfs:comment "An assay to measure the velocity of an evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000987 a rdfs:Class ;
  rdfs:label "obsolete_general scalar measurement datum" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003538 a rdfs:Class ;
  rdfs:label "deep tendon reflex assessment of the tendon of biceps brachii" ;
  rdfs:comment "A deep tendon reflex assessment of an individual's reaction to stimulus applied to a tendon of biceps brachii."@en ;
  rdfs:subClassOf obo:OBI_0003517 .

obo:OBI_0000198 a rdfs:Class ;
  rdfs:label "biological replicate role"@en ;
  rdfs:comment "a reference participant role realized by equivalent treatment of participants"@en ;
  rdfs:subClassOf obo:OBI_0000220 .

obo:OBI_0001724 a rdfs:Class ;
  rdfs:label "viral hemagglutination inhibition assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A viral hemagglutination inhibition assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000875 , obo:OBI_0001703 .

obo:OBI_0003734 a rdfs:Class ;
  rdfs:label "clinical history collection assay" ;
  rdfs:comment "A clinical assay that produces a data item indicating whether an organism has ever had a particular disease, lifestyle factor, immune exposure, or medical procedure."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001584 a rdfs:Class ;
  rdfs:label "phage display binding assay measuring binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A phage display binding assay that detects direct binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001476 , obo:OBI_0001555 .

obo:OBI_0002696 a rdfs:Class ;
  rdfs:label "insecticide resistance by monitoring known mutations assay" ;
  rdfs:comment "An insecticide resistance assay that detects, in a population, presence and frequency of mutant alleles for previously characterized mutations with insecticide resistance phenotypes."@en ;
  rdfs:subClassOf obo:OBI_0002695 .

obo:OBI_0000371 a rdfs:Class ;
  rdfs:label "heat function"@en ;
  rdfs:comment "A heat function is a function that increases the internal kinetic energy of a material"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0001471 a rdfs:Class ;
  rdfs:label "T cell epitope specific immune intervention" ;
  rdfs:comment "An epitope specific immune intervention in which the induced response targets a T cell epitope"@en ;
  rdfs:subClassOf obo:OBI_0001192 .

obo:OBI_0003362 a rdfs:Class ;
  rdfs:label "T1 lesion mask" ;
  rdfs:comment "A lesion mask where the lesions are derived from a T1 weighted image data set."@en ;
  rdfs:subClassOf obo:OBI_0003361 .

obo:CHEBI_17137 a rdfs:Class ;
  rdfs:label "hydrogensulfite" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:GO_0032631 a rdfs:Class ;
  rdfs:label "interleukin-27 production" ;
  rdfs:comment "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0002465 a rdfs:Class ;
  rdfs:label "age since culture seeding measurement datum" ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of a cell since cultured (the process of seeding cells onto a culture dish)."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0001446 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-15 production by T cells" ;
  rdfs:comment "A process of interleukin-15 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032618 , obo:OBI_0001193 .

obo:OBI_1110060 a rdf:Property ;
  rdfs:label "process is result of" ;
  rdfs:comment "is a relationship between a process and a preceding occurrent that directly caused the later one to occur"@en ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002087 .

obo:OBI_0200160 a rdfs:Class ;
  rdfs:label "generalized family wise error rate correction method"@en ;
  rdfs:comment "A generalized FWER correction method is a multiple testing procedure that controls the probability of at least k+1 false positives, where k is a user-supplied integer."@en ;
  rdfs:subClassOf obo:OBI_0200089 .

obo:OBI_0001892 a rdfs:Class ;
  rdfs:label "specification of data to be generated in an investigation"@en ;
  rdfs:comment "An objective specification which indicates the type of data that will be generated and submitted to a database."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:BFO_0000050 a rdf:Property ;
  rdfs:label "part of" ;
  rdfs:comment "a core relation that holds between a part and its whole"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_2100102 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood lymphocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of lymphocytes in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003024 , obo:OBI_0003040 .

obo:OBI_0001593 a rdfs:Class ;
  rdfs:label "competitive inhibition of binding assay" ;
  rdfs:comment "A binding assay that detects the inhibition of binding between 2 material entities known to form a complex by the addition of a third material entity of interest. Inhibition of binding between the 2 materials reflects binding by the third material."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_2100078 a rdfs:Class ;
  rdfs:label "CBC venous blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a CBC order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0001915 a rdfs:Class ;
  rdfs:label "DNA replication timing by array assay" ;
  rdfs:comment "An assay which quantifies the timing of DNA replication as a function of genome position using array technology."@en ;
  rdfs:subClassOf obo:OBI_0002692 .

obo:OBI_0001374 a rdfs:Class ;
  rdfs:label "injury design" ;
  rdfs:comment "A study design in which the response of an organism(s) to injury or damage is studied."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002394 a rdfs:Class ;
  rdfs:label "number of pregnancies" ;
  rdfs:comment "A measurement datum of the total number of pregnancies a woman has had."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0003750 a rdfs:Class ;
  rdfs:label "neurite outgrowth assay" ;
  rdfs:comment "A cell differentiation assay that detects neurite outgrowth and/or branching"@en ;
  rdfs:subClassOf obo:OBI_0003720 .

obo:OBI_0003603 a rdfs:Class ;
  rdfs:label "intratumoral administration" ;
  rdfs:comment "An administration of a substance into a tumor of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0400117 a rdfs:Class ;
  rdfs:label "vacuum dryer" ;
  rdfs:comment "An instrument which removes liquid by the application of negative pressure,  i.e. vacuum."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0000580 a rdfs:Class ;
  rdfs:label "AVANCE II spectrometer" ;
  rdfs:comment "A spectrometer suitable for metabolomics and in vivo NMR studies but structural analysis of small molecules and low molecular weight proteins can also be performed. To accomplish these studies there are six probe-heads available. A successor, the AVANCE III came out recently."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:OBI_0001692 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from fertility" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that uses a epitope protection experiment based on reduction of fertility."@en ;
  rdfs:subClassOf obo:OBI_0001178 , obo:OBI_0001698 .

obo:PATO_0001421 a rdfs:Class ;
  rdfs:label "alive" ;
  rdfs:comment "A viability quality inhering in a bearer by virtue of the bearer's condition before death." ;
  rdfs:subClassOf obo:PATO_0000169 .

obo:OBI_0003294 a rdfs:Class ;
  rdfs:label "modified acid-fast stain microscopy assay" ;
  rdfs:comment "A microscopy assay that uses staining to identify acid-fast organisms in a specimen and does not require heating."@en ;
  rdfs:subClassOf obo:OBI_0002119 .

obo:OBI_0001489 a rdfs:Class ;
  rdfs:label "mass spectrometry assay measuring MHC ligand processing and presentation of MHC ligands eluted from cellular MHC" ;
  rdfs:comment "A mass spectrometry of MHC ligands assay that identifies eluted ligands from cell bound MHC."@en ;
  rdfs:subClassOf obo:OBI_0001478 .

obo:UBERON_0001485 a rdfs:Class ;
  rdfs:label "knee joint" ;
  rdfs:comment "The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_1110043 a rdfs:Class ;
  rdfs:label "cultured adherent cell population"@en ;
  rdfs:comment "A mixed cell population that is characterized by its ability to bind to tissue culture flasks or plates. This population typically contains macrophages and other cells capable of playing the antigen presenting cell role."@en ;
  rdfs:subClassOf obo:OBI_0100060 .

obo:OBI_0001517 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring half maximal inhibitory concentration [IC50] to determine competitive binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures half maximal inhibitory concentration (IC50) to detect the loss of binding of a known reference ligand to cell-bound-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001992 .

obo:OBI_0000692 a rdfs:Class ;
  rdfs:label "recombination enzyme based cloning" ;
  rdfs:comment "a recombination enzyme based cloning is a recombinant vector cloning process that uses complementary nucleotide sequences in both the insert genetic material and the cloning vector with a recombination enzyme to directly create a recombinant vector"@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:IAO_0000009 a rdfs:Class ;
  rdfs:label "datum label"@en ;
  rdfs:comment "A label is a symbol that is part of some other datum and is used to either partially define  the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0000649 a rdfs:Class ;
  rdfs:label "data set of features"@en ;
  rdfs:comment "A data set that is produced as the output of a descriptive statistical calculation data transformation and consists of producing a data set that represents one or more features of interest about the input data set."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0003232 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid assay" ;
  rdfs:comment "An assay that has a cerebrospinal fluid specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100372 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood lactic acid assay" ;
  rdfs:comment "An assay that measures lactic acid in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100042 .

obo:MRO_0001537 a rdfs:Class ;
  rdfs:label "HLA protein complex with A28 serotype" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:GO_0071611 a rdfs:Class ;
  rdfs:label "granulocyte colony-stimulating factor production" ;
  rdfs:comment "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0002458 a rdfs:Class ;
  rdfs:label "chromosome conformation capture-on-chip assay" ;
  rdfs:comment "A nuclear ligation assay which uses cross-linking of proteins to proteins and DNA, followed by two rounds of digestion and ligation, inverse PCR, and characterization by microarray or DNA sequencing. This enables unbiased genome-wide screens for DNA contacts made by single genomic sites of interest."@en ;
  rdfs:subClassOf obo:OBI_0002438 , obo:OBI_0002692 .

obo:OBI_2100222 a rdfs:Class ;
  rdfs:label "venous blood ammonia assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ammonia in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_0001677 a rdfs:Class ;
  rdfs:label "epitope specific granulysin production by T cells" ;
  rdfs:comment "A process of granulysin production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0036262 .

obo:OBI_0002934 a rdfs:Class ;
  rdfs:label "MosquiTRAP" ;
  rdfs:comment "A gravid trap consisting of an arthropod attractant and adhesive surface."@en ;
  rdfs:subClassOf obo:OBI_0002929 .

obo:OBA_2060180 a rdfs:Class ;
  rdfs:label "limb coordination efficacy" ;
  rdfs:comment "The process efficacy of a limb coordination." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:OBI_2100253 a rdfs:Class ;
  rdfs:label "POC chem8 arterial blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in arterial blood as part of a POC chem8 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0001961 a rdfs:Class ;
  rdfs:label "PCR program"@en ;
  rdfs:comment "a PCR program is a plan specification which is executed during a polymerase chain reaction (PCR) by a thermocycler instrument that will iterate through the changes in temperature and duration of each of the annealing, denaturation, elongation steps for as many times as specified by the program."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:GO_0006338 a rdfs:Class ;
  rdfs:label "chromatin remodeling" ;
  rdfs:comment "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0200147 a rdfs:Class ;
  rdfs:label "network graph quality calculation"@en ;
  rdfs:comment "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of the network as a whole."@en ;
  rdfs:subClassOf obo:OBI_0200080 .

obo:OBI_2100214 a rdfs:Class ;
  rdfs:label "hepatic panel venous blood alanine aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a hepatic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100016 .

obo:OBI_0000065 a rdfs:Class ;
  rdfs:label "polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether"@en ;
  rdfs:comment "triton X100 is a chemical entity which belongs to the group of The pluronics which are triblock copolymers of ethylene oxide and propylene oxide. Triton x-100 is_used_as detergent due to its non-ionic surfactant properties"@en ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003303 a rdfs:Class ;
  rdfs:label "single cell combinatorial indexing Hi-C assay" ;
  rdfs:comment "A Hi-C assay performed on massively multiplexed single-cell samples."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:OBI_0003317 a rdfs:Class ;
  rdfs:label "perforin release during T cell degranulation" ;
  rdfs:comment "The release of perforin during cytotoxic T cell degranulation."@en ;
  rdfs:subClassOf obo:GO_0035944 .

obo:OBI_0001323 a rdfs:Class ;
  rdfs:label "microRNA profiling by array design" ;
  rdfs:comment "A study design in which a microRNA array is used to analyse the microRNA component of the transcriptome."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:SO_0000353 a rdfs:Class ;
  rdfs:label "sequence_assembly" ;
  rdfs:comment "A sequence of nucleotides that has been algorithmically derived from an alignment of two or more different sequences." ;
  rdfs:subClassOf obo:SO_0001248 .

obo:OBI_0000102 a rdfs:Class ;
  rdfs:label "responsible party role"@en ;
  rdfs:comment "a study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study"@en ;
  rdfs:subClassOf obo:OBI_0000202 .

obo:OBI_2100038 a rdfs:Class ;
  rdfs:label "reticulocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of reticulocytes"@en ;
  rdfs:subClassOf obo:OBI_0003026 .

obo:OBI_0000804 a rdfs:Class ;
  rdfs:label "informing investigator of subject study arm" ;
  rdfs:comment "A planned process with the objective to make the investigator aware of which study arm a patient is participating in."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002811 a rdfs:Class ;
  rdfs:label "protective sleeve" ;
  rdfs:comment "A personal protective clothing item which is a protective cover worn over the arm."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_0001215 a rdfs:Class ;
  rdfs:label "intracellular material detection assay measuring epitope specific perforin release" ;
  rdfs:comment "A flow cytometry assay that detects epitope specific perforin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001497 .

obo:OBI_0003578 a rdfs:Class ;
  rdfs:label "bone marrow microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a bone marrow specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:GO_0042110 a rdfs:Class ;
  rdfs:label "T cell activation" ;
  rdfs:comment "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_1110028 a rdfs:Class ;
  rdfs:label "293-T cell line"@en ;
  rdfs:comment "A cell line derived from human embryonic kidney cells. This cell line contains the SV40 Large T-antigen, allowing episomal replication of transfected plasmids containing the SV40 origin of replication."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0001612 a rdfs:Class ;
  rdfs:label "epitope specific vascular endothelial growth factor production by T cells" ;
  rdfs:comment "A process of vascular endothelial growth factor production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0010573 , obo:OBI_0001193 .

obo:GO_0001816 a rdfs:Class ;
  rdfs:label "cytokine production" ;
  rdfs:comment "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003373 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific lymphotactin production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects lymphotactin production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0003372 .

obo:OBI_0001331 a rdfs:Class ;
  rdfs:label "transcription profiling identification objective"@en ;
  rdfs:comment "A molecular feature identification objective that aims to characterize the abundance of transcripts"@en ;
  rdfs:subClassOf obo:OBI_0000131 .

obo:OBI_0300310 a rdfs:Class ;
  rdfs:label "sequential design" ;
  rdfs:comment "Any design in which the decision as to whether to enroll the next patient, pair of patients, or block of patients is determined by whether the cumulative treatment difference for all previous patients is within specified limits.  Enrollment is continued if the difference does not exceed the limits.  It is terminated if it does"@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:OBI_0002771 a rdfs:Class ;
  rdfs:label "full karyotype information"@en ;
  rdfs:comment "A karyotype information that is about the structural variation of the whole genome."@en ;
  rdfs:subClassOf obo:OBI_0002769 .

obo:OBI_0003807 a rdfs:Class ;
  rdfs:label "biotelemeter" ;
  rdfs:comment "A measurement device that also transmits the measurement information from a biological material to a distant station."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0003647 a rdfs:Class ;
  rdfs:label "tandem mass spectrometry analysis" ;
  rdfs:subClassOf obo:OBI_0200085 .

obo:OBI_0002538 a rdfs:Class ;
  rdfs:label "cerebellum specimen" ;
  rdfs:comment "A specimen that is derived from cerebellum."@en ;
  rdfs:subClassOf obo:OBI_0002516 .

obo:OBI_0003205 a rdfs:Class ;
  rdfs:label "high-density lipoprotein concentration assay" ;
  rdfs:comment "A lipoprotein concentration assay that measures the concentration of high-density lipoprotein in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003204 .

obo:OBI_0400050 a rdfs:Class ;
  rdfs:label "Guava Personal Cell Analysis" ;
  rdfs:comment "A  Guava_Personal_Cell_Analysis System is a flow_cytometer_analyser that includes a single 532 nm laser, and filters and PMTs to collect up to 2 fluorescent parameters. It includes a photodiode forward scatter collector. Guava cytometers use aspiration instead of fluid systems to transport cells within the machine. The PCA96 uses only tubes to introduce specimen. The Guava PCA cytometer is a small portable cytometer particularly useful for field measurement."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0200183 a rdfs:Class ;
  rdfs:label "scaling objective"@en ;
  rdfs:comment "is a data transformation objective where all, or some of a data set is adjusted by some data transformation according to some scale, for example a user defined minimum or maximum"@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:UBERON_0002384 a rdfs:Class ;
  rdfs:label "connective tissue" ;
  rdfs:comment "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:OBI_0001255 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-5 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-5 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001230 .

obo:OBI_1110177 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-10 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001209 .

obo:OBI_0001061 a rdfs:Class ;
  rdfs:label "microwave synthesis system" ;
  rdfs:comment "A device that is used to apply microwave irradiation to chemical reactions."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000562 a rdfs:Class ;
  rdfs:label "anion trap column" ;
  rdfs:comment "An anion trap column is a trap column and ion-exchange column which contains cationic anion-exchange resins."@en ;
  rdfs:subClassOf obo:OBI_0000518 .

obo:OBI_0100063 a rdfs:Class ;
  rdfs:label "cultured clonal cell population"@en ;
  rdfs:comment "A cultured cell population comprised of cells which can all be traced back to a single ancestor cell, and which therefore can be treated as identical."@en ;
  rdfs:subClassOf obo:OBI_0100060 .

obo:IAO_0000055 a rdfs:Class ;
  rdfs:label "rule"@en ;
  rdfs:comment "A rule is an executable which guides, defines, restricts actions."@en ;
  rdfs:subClassOf obo:IAO_0000001 .

obo:OBI_0000478 a rdfs:Class ;
  rdfs:label "column connector" ;
  rdfs:comment "A device that connects two or more columns together in a functional way with leak-tight connection, low dead volume, low thermal mass and high inertness."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_1110017 a rdfs:Class ;
  rdfs:label "living with infected household contact"@en ;
  rdfs:comment "a process in which a a human being lives in the same household as another human being that is known to be infected with an infectious agent"@en ;
  rdfs:subClassOf obo:OBI_1110111 .

obo:OBI_2100113 a rdfs:Class ;
  rdfs:label "lipid panel venous blood high density lipoprotein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of high density lipoprotein in venous blood as part of a lipid panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100030 .

obo:OBI_0003898 a rdfs:Class ;
  rdfs:label "differential leukocyte count assay" ;
  rdfs:comment "A hematology assay that measures the percentage of classes of leukocytes in a sample."@en ;
  rdfs:subClassOf obo:OBI_0000630 , obo:OBI_0003040 .

obo:OBI_0001195 a rdfs:Class ;
  rdfs:label "operator variation design" ;
  rdfs:comment "A study design that assesses the operator performance and relation to data consistency and quality."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002738 a rdfs:Class ;
  rdfs:label "organism detection by isoenzyme electrophoresis assay" ;
  rdfs:comment "An organism detection assay that is based on electrophoresis to determine the isozymes that are present in a specific population to determine the species."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:GO_0060136 a rdfs:Class ;
  rdfs:label "embryonic process involved in female pregnancy" ;
  rdfs:comment "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." ;
  rdfs:subClassOf obo:GO_0022414 .

obo:OBI_0003661 a rdfs:Class ;
  rdfs:label "in vitro CRISPR screen using flow cytometry" ;
  rdfs:comment "An in vitro CRISPR screen assay that uses flow cytometry to detect induced changes in gene expression of the targeted genes."@en ;
  rdfs:subClassOf obo:OBI_0003659 .

obo:OBI_0002061 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific chemokine (C-C motif) ligand 22 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects chemokine (C-C motif) ligand 22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001777 , obo:OBI_0003115 .

obo:OBI_2100141 a rdfs:Class ;
  rdfs:label "cooximitery arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a cooximitery order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0003244 a rdfs:Class ;
  rdfs:label "blood microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a blood microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003243 .

obo:OBI_0000992 a rdfs:Class ;
  rdfs:label "DNA sequencing service" ;
  rdfs:comment "A DNA sequencing  process provided as a service - which is the realization of some DNA sequencing in which the service provider role is realized."@en ;
  rdfs:subClassOf obo:OBI_0001904 .

obo:OBI_0000107 a rdf:Property ;
  rdfs:label "provides_service_consumer_with" ;
  rdfs:comment "A relation between a service and the primary processual part of the service that is performed by the provider for the consumer."@en ;
  rdfs:domain obo:OBI_0001173 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:OBI_0003633 a rdfs:Class ;
  rdfs:label "antibody purification of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype" ;
  rdfs:comment "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003627 .

obo:OBI_0003926 a rdfs:Class ;
  rdfs:label "assembly-based metagenome binning" ;
  rdfs:comment "A metagenome binning that clusters contigs assembled from shotgun metagenomic reads into bins based on their putative genomic origin, yielding metagenome-assembled genomes (MAGs)."@en ;
  rdfs:subClassOf obo:OBI_0003924 .

obo:OBI_0400018 a rdfs:Class ;
  rdfs:label "Cell Lab Quanta SC" ;
  rdfs:comment "A Cell Lab Quanta SC is a flow_cytometer_analyser manufactured by Becman Coulter. It features a mercury arc lamp optimized at 366, 405, and 435 nm, and a 488 nm laser diode. It has filters and PMTs to collect up to 3 fluorescent parameters, and a photodiode for side scatter detection. This cytometer uses Couter-Volume for cell size measurements. The Cell Lab Quanta SC can be used for measuring the properties of individual cells."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OPL_0000232 a rdfs:Class ;
  rdfs:label "parasite organism" ;
  rdfs:comment "An organism living in, with, or on another organism in parasitism. Individual members of parasite species, such as Leishmania, Plasmodium, Trypanosoma, etc. are members of this class." ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0003221 a rdfs:Class ;
  rdfs:label "free fatty acid concentration assay" ;
  rdfs:comment "A fatty acid assay that measures the concentration of free fatty acids in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003220 .

obo:CHEBI_33375 a rdfs:Class ;
  rdfs:label "gadolinium atom" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001055 a rdfs:Class ;
  rdfs:label "spinning-disk confocal microscope" ;
  rdfs:comment "A confocal microscope that uses a Nipkow disk, a mechanical, geometrically operating image scanning device."@en ;
  rdfs:subClassOf obo:OBI_0001079 .

obo:OBI_0200070 a rdfs:Class ;
  rdfs:label "edge weighting"@en ;
  rdfs:comment "Edge weighting is the substitution or transformation of edge length using numerical data.  Data input include a symmetric adjacency matrix for a network and a second data set, for example a list of interactor pairs and a confidence score associated with the experimental detection of each pair's interaction.  Each element in the adjacency matrix is transformed or replaced with the corresponding number in the second data set.  Output data are a modified adjacency matrix reflecting the transformed state of the network."@en ;
  rdfs:subClassOf obo:OBI_0200080 .

obo:IAO_8000014 a rdfs:Class ;
  rdfs:label "generated ontology module"@en ;
  rdfs:comment "An ontology module that is automatically generated, for example via a SPARQL query or via template and a CSV."@en ;
  rdfs:subClassOf obo:IAO_8000000 .

obo:OBI_0600060 a rdfs:Class ;
  rdfs:label "DNA transfection"@en ;
  rdfs:comment "a transfection which relies on the use of physical, electrical and chemical phenomena to introduce DNA into a cell"@en ;
  rdfs:subClassOf obo:OBI_0001152 .

obo:OBI_0002678 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific disease exacerbation resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that uses a disease exacerbation in vivo intervention experiment after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0001188 , obo:OBI_0001467 , obo:OBI_0002676 .

obo:OBI_0000934 a rdfs:Class ;
  rdfs:label "intramuscular injection" ;
  rdfs:comment "is the injection of a material entity (bearing the administered substance role) into the muscle (bearing the target role) of an organism using a syringe"@en ;
  rdfs:subClassOf obo:OBI_0000426 , obo:OBI_0600007 .

obo:OBI_0001807 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-3 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001406 , obo:OBI_0003115 .

obo:OBI_0002671 a rdfs:Class ;
  rdfs:label "in vivo assay measuring epitope specific T cell killing resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An in vivo cell killing assay that detects the killing of an antigen presenting cell (APC) by a T cell whose TCR recognizes an epitope presented by the APC after adoptive transfer of epitope specific T cells."@en ;
  rdfs:subClassOf obo:OBI_0000883 , obo:OBI_0001392 , obo:OBI_0002676 .

obo:OBI_0001628 a rdfs:Class ;
  rdfs:label "investigation identifier"@en ;
  rdfs:comment "A CRID symbol used to identify an investigation."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0003261 a rdfs:Class ;
  rdfs:label "bacteria in blood datum" ;
  rdfs:comment "A blood microbiology datum that is about bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003244 .

obo:OBI_0002591 a rdfs:Class ;
  rdfs:label "colocalization identification design" ;
  rdfs:comment "A molecular interaction identification design that investigates the co-occurence and correlation of two or more molecules."@en ;
  rdfs:subClassOf obo:OBI_0002590 .

obo:OBI_0001026 a rdfs:Class ;
  rdfs:label "NMIA RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using NMIA as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:GO_0032635 a rdfs:Class ;
  rdfs:label "interleukin-6 production" ;
  rdfs:comment "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003012 a rdfs:Class ;
  rdfs:label "ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_2100279 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_1110158 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-6 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-6 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001451 .

obo:OBI_0200172 a rdfs:Class ;
  rdfs:label "partitioning objective"@en ;
  rdfs:comment "A partitioning objective is a data transformation objective where the aim is to generate a collection of disjoint non-empty subsets whose union equals a non-empty input set."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002956 a rdfs:Class ;
  rdfs:label "targeted, drug-modulated, mass spectrometry-based protein phoshporylation-state assay" ;
  rdfs:comment "A type of mass spectrometry protein state assay that measures levels of a targeted set of proteins in different phosphorylation states in response to drug perturbations."@en ;
  rdfs:subClassOf obo:OBI_0002955 .

obo:CHEBI_86319 a rdfs:Class ;
  rdfs:label "25-hydroxyvitamin D2" ;
  rdfs:comment "A hydroxycalciol that is vitamin D<small><sub>2</sub></small> in which the hydrogen at position 25 has been replaced by a hydroxy group." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000880 a rdfs:Class ;
  rdfs:label "RNA extract" ;
  rdfs:comment "an extract which is the output of an extraction process in which RNA molecules are isolated from a specimen."@en ;
  rdfs:subClassOf obo:OBI_0001010 .

obo:OBI_0003506 a rdfs:Class ;
  rdfs:label "finger to finger assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to touch index fingers together in front of the sternum without oscillation for a specified duration of time"@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0000083 a rdfs:Class ;
  rdfs:label "electronic case report tabulation"@en ;
  rdfs:comment "An electronic case report tabulation is a digital document containing tabular data about multiple trial participants which is part of a clinical regulatory submission.  An eCRT has the property that it can be audited and compliant with requirements of 21 CFR Part 11  and has format suited to review by regulators."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0000291 a rdfs:Class ;
  rdfs:label "transcription factor binding site assay" ;
  rdfs:comment "An assay tthat determines DNA regions specifically recognized by proteins that function as transcription factors"@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0000832 a rdfs:Class ;
  rdfs:label "measurement device" ;
  rdfs:comment "A device in which a measure function inheres."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:IAO_0000416 a rdfs:Class ;
  rdfs:label "time measurement datum"@en ;
  rdfs:comment "A scalar measurement datum that is the result of measuring a temporal interval"@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_1110082 a rdfs:Class ;
  rdfs:label "immunogen role"@en ;
  rdfs:comment "A role of a material entity that is realized when the material elicits an immune response targeting itself in whole or in part."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:PATO_0001292 a rdfs:Class ;
  rdfs:label "full-spectrum EM radiation quality" ;
  rdfs:comment "An EM radiation quality that is independent of the EM wavelength range." ;
  rdfs:subClassOf obo:PATO_0070060 .

obo:OBI_0003418 a rdfs:Class ;
  rdfs:label "antigen specific antibodies in blood assay" ;
  rdfs:comment "An antigen specific antibodies assay that has a blood specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0002145 , obo:OBI_0003040 .

obo:OBI_0000705 a rdfs:Class ;
  rdfs:label "Edman degradation" ;
  rdfs:comment "A sequencing assay in which the amino acid sequence of input peptides or proteins is determined by iteratively cleaving of the amino-terminal (N-terminal) residue without disrupting the peptide bonds and identifying it by e.g. chromatography or electropheresis."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_0002963 a rdfs:Class ;
  rdfs:label "KINOMEscan assay" ;
  rdfs:comment "A type of proprietary kinase inhibitor assay that and employs a panel of kinases against which one can test compounds for their selectivity and potency in interactions with kinases, without the need to add ATP to the reactions."@en ;
  rdfs:subClassOf obo:OBI_0002962 .

obo:OBI_0002516 a rdfs:Class ;
  rdfs:label "brain specimen" ;
  rdfs:comment "A specimen that is derived from brain."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0500010 a rdfs:Class ;
  rdfs:label "reference design" ;
  rdfs:comment "A reference experiment design type is where all samples are compared to a common reference."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:NCBITaxon_4932 a rdfs:Class ;
  rdfs:label "Saccharomyces cerevisiae" ;
  rdfs:subClassOf obo:NCBITaxon_716545 .

obo:OBI_0002607 a rdfs:Class ;
  rdfs:label "oral swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the inside surface of a mouth."@en ;
  rdfs:subClassOf obo:OBI_0001479 , obo:OBI_0002599 .

obo:OBI_0001933 a rdfs:Class ;
  rdfs:label "value specification" ;
  rdfs:comment "An information content entity that specifies a value within a classification scheme or on a quantitative scale."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0002135 a rdf:Property ;
  rdfs:label "has specified value"@en ;
  rdfs:comment "A relation between a value specification and a literal."@en ;
  rdfs:domain obo:OBI_0001933 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0001927 a rdf:Property ;
  rdfs:label "specifies value of" ;
  rdfs:comment "A relation between a value specification and an entity which the specification is about."@en ;
  rdfs:domain obo:OBI_0001933 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:OBI_0001937 a rdf:Property ;
  rdfs:label "has specified numeric value" ;
  rdfs:comment "A relation between a value specification and a number that quantifies it."@en ;
  rdfs:domain obo:OBI_0001933 ;
  rdfs:range <http://www.w3.org/2002/07/owl#real> ;
  rdfs:subPropertyOf obo:OBI_0002135 .

obo:OBI_2100300 a rdfs:Class ;
  rdfs:label "bone profile venous blood human alkaline phosphatase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a bone profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100017 .

obo:OBI_2100026 a rdfs:Class ;
  rdfs:label "nucleate erythrocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of nucleate erythrocytes"@en ;
  rdfs:subClassOf obo:OBI_0003018 .

obo:OBI_0001539 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to cell-bound-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001988 .

obo:OBI_2100045 a rdfs:Class ;
  rdfs:label "tobramycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of tobramycin"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001349 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-13 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001251 , obo:OBI_0003115 .

obo:OBI_2000006 a rdfs:Class ;
  rdfs:label "upper respiratory tract specimen" ;
  rdfs:comment "A specimen that is derived from some upper respiratory tract"@en ;
  rdfs:subClassOf obo:OBI_2000005 .

obo:OBI_2100085 a rdfs:Class ;
  rdfs:label "liver evaluation venous blood human alkaline phosphatase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a liver evaluation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100017 .

obo:GO_0045005 a rdfs:Class ;
  rdfs:label "DNA-templated DNA replication maintenance of fidelity" ;
  rdfs:comment "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_2100334 a rdfs:Class ;
  rdfs:label "manual differential bodily fluid lymphocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of lymphocytes in bodily fluid as part of a manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003024 .

obo:OBI_0001291 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-17 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001295 .

obo:OBI_0200129 a rdfs:Class ;
  rdfs:label "node quality calculation"@en ;
  rdfs:comment "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of one of the node objects in the network."@en ;
  rdfs:subClassOf obo:OBI_0200080 .

obo:OBI_0100039 a rdfs:Class ;
  rdfs:label "obsolete_fragment derived from protein" ;
  rdfs:comment "A material entity which is derived from a  protein"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100236 a rdfs:Class ;
  rdfs:label "chem16 venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:CL_0000767 a rdfs:Class ;
  rdfs:label "basophil" ;
  rdfs:comment "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." ;
  rdfs:subClassOf obo:CL_0000081 , obo:CL_0000738 .

obo:OBI_0003611 a rdfs:Class ;
  rdfs:label "precursor role"@en ;
  rdfs:comment "A role borne by a biological or chemical entity which serves as the core component of a chemical reaction process, upon which other reactants, like reagents or solvents, act."@en ;
  rdfs:subClassOf obo:OBI_0003610 .

obo:OBI_0001793 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific lymphotoxin A production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects lymphotoxin A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001327 , obo:OBI_0001368 , obo:OBI_0003115 .

obo:OBI_0001972 a rdfs:Class ;
  rdfs:label "Ion 318 Chip v2" ;
  rdfs:comment "An ion semiconductor chip manufactured by Life Technologies which detects polymerase-driven base incorporation to translate into digital form. The 318 chip is compatible with the Ion Torrent PGM and has a run time of: 4.4 hours for 200 bp reads with an output of 60 Mb-1 Gb, 7.3 hours for 400 bp reads with an output of 1.2 Gb-2 Gb."@en ;
  rdfs:subClassOf obo:OBI_0001973 .

obo:OBI_0002786 a rdfs:Class ;
  rdfs:label "personal protective device" ;
  rdfs:comment "A device which is a wearable garment designed to protect the wearer's body from injury or infection."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000172 a rdfs:Class ;
  rdfs:label "parameter threshold"@en ;
  rdfs:comment "A measurement datum measuring the minimal signal that must be detected to generate an electrical event, as compared to the maximal detected signal in a flow cytometer instrument. The datum has a qualitative role"@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0001707 a rdfs:Class ;
  rdfs:label "immunoglobulin mediated histamine release" ;
  rdfs:comment "The release of histamine by cells stimulated through their Fc receptors which are loaded with immunoglobulins."@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0002101 a rdfs:Class ;
  rdfs:label "small-angle scattering assay determining the 3D structure of a B cell epitope:antibody complex" ;
  rdfs:comment "A small-angle scattering 3D molecular structure determination assay that characterizes the 3-dimensional molecular structure of a B cell epitope:antibody complex"@en ;
  rdfs:subClassOf obo:OBI_0001721 , obo:OBI_0002108 .

obo:OBI_0003585 a rdfs:Class ;
  rdfs:label "carboxyfluorescein succinimidyl ester staining"@en ;
  rdfs:comment "Staining using carboxyfluorescein succinimidyl ester."@en ;
  rdfs:subClassOf obo:OBI_0302887 .

obo:OBI_0001955 a rdfs:Class ;
  rdfs:label "competitive binding reference ligand role" ;
  rdfs:comment "A positive reference substance role that inheres in a material entity that is known to bind to a target entity, and that is realized in a competitive binding assay that has as specified input the target entity, an evaluant and the positive reference substance, where the binding of the evaluant to the target is measured based on the evaluant's ability to compete with the positive reference substance for binding to the target."@en ;
  rdfs:subClassOf obo:OBI_0000064 .

obo:OBI_0001044 a rdfs:Class ;
  rdfs:label "angiograph" ;
  rdfs:comment "A device that records the patterns of pulse waves inside blood vessels."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:CHEBI_28619 a rdfs:Class ;
  rdfs:label "acrylamide" ;
  rdfs:comment "A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0400039 a rdfs:Class ;
  rdfs:label "FACS Scan" ;
  rdfs:comment "A FACS_Scan is a flow_cytometer_analyser manufactured by Becton Dickinson. IT features analog electronics, one 488 nm solid state laser, and the filters and PMTs to collect up to three fluorescent parameters The FACS_Scan is usually used for research applications."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0001587 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-7 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-7 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002565 a rdfs:Class ;
  rdfs:label "adapter-sequence trimming" ;
  rdfs:comment "A data transformation in which adapter sequences at the end of a molecular sequence are cut (removed)."@en ;
  rdfs:subClassOf obo:OBI_0002585 .

obo:OBI_0200116 a rdfs:Class ;
  rdfs:label "loess fitting"@en ;
  rdfs:comment "A loess fitting is a curve fitting obtained by localized regression. The latter refers to fitting a polynomial (straight line, quadratic, cubic, etc) to data values within a window covering a fraction of the total number of observations. As the window slides along the axis, a new polynomial is fit to the observations falling within the window. This continues until all points are fit with a local polynomial. The results are then smoothed together to form a curve. The smoothness of loess fits is controlled by a smoothing parameter (often denoted as alpha, usually between 1/4 and 1) and the degree of the polynomial that is fitted by the method (usually denoted by lambda)."@en ;
  rdfs:subClassOf obo:OBI_0200072 .

obo:OBI_0002437 a rdfs:Class ;
  rdfs:label "widefield microscopy assay" ;
  rdfs:comment "A fluorescence microscopy technique where the specimen under investigation is fully bathed in light, as opposed to confocal microscopy in which only a small portion of the specimen is illuminated."@en ;
  rdfs:subClassOf obo:CHMO_0000087 .

obo:OBI_0003657 a rdfs:Class ;
  rdfs:label "minimum resolved unit of measurement"@en ;
  rdfs:comment "An information content entity that indicates the smallest increment that can be resolved on the scale of a measurement instrument."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003830 a rdfs:Class ;
  rdfs:label "cell viability assay using luciferase to detect ATP in the cell" ;
  rdfs:comment "A cell viability assay that uses an ATP bioluminescence assay to detect ATP in the living cell"@en ;
  rdfs:subClassOf obo:OBI_0003583 .

obo:PATO_0070060 a rdfs:Class ;
  rdfs:label "quality of interaction of a substance with electromagnetic radiation" ;
  rdfs:comment "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." ;
  rdfs:subClassOf obo:PATO_0002198 .

obo:MRO_0001557 a rdfs:Class ;
  rdfs:label "HLA protein complex with B27 serotype" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:OBI_2100348 a rdfs:Class ;
  rdfs:label "TSH reflex Free T4 venous blood thyroid stimulating hormone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of thyroid stimulating hormone in venous blood as part of a TSH reflex Free T4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100033 .

obo:NCBITaxon_6239 a rdfs:Class ;
  rdfs:label "Caenorhabditis elegans" ;
  rdfs:subClassOf obo:NCBITaxon_1206794 .

obo:OBI_0003052 a rdfs:Class ;
  rdfs:label "larval specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process in which the arthropods are in the larval stage."@en ;
  rdfs:subClassOf obo:OBI_0002907 .

obo:OBI_0001071 a rdfs:Class ;
  rdfs:label "programmable array microscope" ;
  rdfs:comment "A confocal microscope that uses a programmable spatial light modulator for generating an arbitrary pattern of conjugate illumination and detection apertures."@en ;
  rdfs:subClassOf obo:OBI_0001079 .

obo:OBI_0000525 a rdfs:Class ;
  rdfs:label "splitless GC injector" ;
  rdfs:comment "Injected sample enters column immediately (while split valve to split vent is closed). Here a sample is introduced into a heated small chamber via a syringe through a septum - the heat facilitates volatilization of the sample and sample matrix. The carrier gas then either sweeps the entirety (splitless mode) or a portion (split mode) of the sample into the column. In split mode, a part of the sample/carrier gas mixture in the injection chamber is exhausted through the split vent."@en ;
  rdfs:subClassOf obo:OBI_0000504 .

obo:OBI_2100269 a rdfs:Class ;
  rdfs:label "venous blood dehydroepiandrosterone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of dehydroepiandrosterone in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_0000663 a rdfs:Class ;
  rdfs:label "class prediction data transformation"@en ;
  rdfs:comment "A class prediction data transformation (sometimes called supervised classification) is a data transformation that has objective class prediction."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001457 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-8 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-8 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001218 , obo:OBI_0003115 .

obo:OBI_0002446 a rdfs:Class ;
  rdfs:label "proteomic profiling design" ;
  rdfs:comment "A study design in which proteins in a sample are detected, quantified or otherwise analysed."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:GO_0030182 a rdfs:Class ;
  rdfs:label "neuron differentiation" ;
  rdfs:comment "The process in which a relatively unspecialized cell acquires specialized features of a neuron." ;
  rdfs:subClassOf obo:GO_0030154 .

obo:OBI_2100011 a rdfs:Class ;
  rdfs:label "erythrocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of erythrocytes"@en ;
  rdfs:subClassOf obo:OBI_0003018 .

obo:OBI_2100110 a rdfs:Class ;
  rdfs:label "venous blood lactate dehydrogenase assay" ;
  rdfs:comment "An assay that measures lactate dehydrogenase in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100028 .

obo:OBI_0000716 a rdfs:Class ;
  rdfs:label "ChIP-seq assay" ;
  rdfs:comment "An assay in which chromatin is immunoprecipitated and subsequently analyzed using a DNA sequencing step to identify which parts of DNA are part of the isolated chromatin"@en ;
  rdfs:subClassOf obo:OBI_0001954 .

obo:OBI_0001385 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects tumor necrosis factor superfamily cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001400 .

obo:OBI_0000790 a rdfs:Class ;
  rdfs:label "recombinant BAC cloning" ;
  rdfs:comment "Recombinant BAC cloning is a  process with the objective to insert genetic material into an F plasmid based bacterial artificial chromosome for future replication of the inserted material"@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_1110093 a rdfs:Class ;
  rdfs:label "disposition to infect an organism"@en ;
  rdfs:comment "Is a role borne by an agent, and realized when in contact with or inside another organism in which it is capable of replicating and causing disease"@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_0001110 a rdfs:Class ;
  rdfs:label "real-time PCR machine" ;
  rdfs:comment "An PCR instrument that enables both detection and quantification of one or more specific sequences in a DNA sample."@en ;
  rdfs:subClassOf obo:OBI_0000989 .

obo:OBI_0003389 a rdfs:Class ;
  rdfs:label "Agilent-030493 SurePrint G3 Mouse Exon 4x180K Microarray" ;
  rdfs:comment "A DNA microarray manufactured with Agilent 60-mer SurePrint Technology for studying exon-level gene expression changes. The SurePrint G3 Mouse Exon 4x180K Microarray include probes targeting individual exons. Each glass slide formatted with four 180K arrays."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0003325 a rdfs:Class ;
  rdfs:label "high throughput multiplexed assay measuring binding of a MHC:ligand complex" ;
  rdfs:comment "A MHC ligand assay that detects the binding of a ligand to an MHC molecule using a high throughput multiplexed assay."@en ;
  rdfs:subClassOf obo:OBI_1110126 .

obo:OBI_0002726 a rdfs:Class ;
  rdfs:label "insecticide resistance by PCR-RFLP assay" ;
  rdfs:comment "An insecticide resistance by monitoring known mutations assay based on restriction fragment length polymorphism assay."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0002696 .

obo:OBI_0003470 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An in vivo assay measuring a T cell epitope specific protection from a pathogen challenge after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001179 , obo:OBI_0002637 .

obo:OBI_0002646 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific tolerance induction resulting from the adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that uses a tolerance induction intervention experiment after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001488 , obo:OBI_0001693 , obo:OBI_0002677 .

obo:GO_0005694 a rdfs:Class ;
  rdfs:label "chromosome" ;
  rdfs:comment "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." ;
  rdfs:subClassOf obo:GO_0005575 .

obo:OBI_0000076 a rdfs:Class ;
  rdfs:label "unplanned occurrence effecting an investigation"@en ;
  rdfs:comment "a process which is external in origin to the investigation that has an impact on the outcome."@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:GO_0004364 a rdfs:Class ;
  rdfs:label "glutathione transferase activity" ;
  rdfs:comment "Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0000519 a rdfs:Class ;
  rdfs:label "flow probe" ;
  rdfs:comment "An NMR probe that allows the automatized flow-through of a sample. The sample is aspirated via a syringe pump into the Flow probe, the NMR spectrum is acquired and when the experiment is complete, the sample is returned to back to an external source (well plate) or flushed to waste. Sometimes pulsed field gradients (PFG) can be established in flow probes."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_2100365 a rdfs:Class ;
  rdfs:label "venous blood megakaryocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of megakaryocytes in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:OBI_0001548 a rdfs:Class ;
  rdfs:label "equilibrium association constant (KA)" ;
  rdfs:comment "A binding constant defined as the ratio of koff over kon (off-rate of binding divided by on-rate)"@en ;
  rdfs:subClassOf obo:OBI_0001144 .

obo:OBI_2100130 a rdfs:Class ;
  rdfs:label "inpatient profile venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a inpatient profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0001966 a rdfs:Class ;
  rdfs:label "sequence library data demultiplexing"@en ;
  rdfs:comment "is a data transformation which uses sequence alignment and  'multiplex identifier sequence' information to separate all reads belonging to a given single sample following the sequencing of a multiplexed library"@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_0001308 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific IP-10 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects IP-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0003755 a rdfs:Class ;
  rdfs:label "micronucleus assay" ;
  rdfs:comment "A cell based DNA damage assay in eukaryotic cells that detects cytoplasmic micronuclei."@en ;
  rdfs:subClassOf obo:OBI_0003721 .

obo:OBI_0001342 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-21 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001237 .

obo:OBI_0002108 a rdfs:Class ;
  rdfs:label "small-angle scattering 3D molecular structure determination assay" ;
  rdfs:comment "A 3D molecular structure determination assay in which the scattering pattern of a neutron or x-ray beam targeted at a material entity is recorded at small angles relative to the incident beam to determine the size, shape and structure of the material entity examined."@en ;
  rdfs:subClassOf obo:OBI_0003117 .

obo:OBI_0200086 a rdfs:Class ;
  rdfs:label "spread calculation data transformation"@en ;
  rdfs:comment "A spread calculation is a data transformation that has objective spread calculation."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_1110130 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific T cell killing" ;
  rdfs:comment "A T cell epitope dependent biological activity assay that detects the killing of an antigen presenting cell (APC) by a T cell whose TCR recognizes an epitope presented by the APC."@en ;
  rdfs:subClassOf obo:OBI_0000882 , obo:OBI_0002055 .

obo:OBI_0200042 a rdfs:Class ;
  rdfs:label "hierarchical clustering"@en ;
  rdfs:comment "A hierarchical clustering is a data transformation which achieves a class discovery objective, which takes as input data item and builds a hierarchy of clusters. The traditional representation of this hierarchy is a tree (visualized by a dendrogram), with the individual input objects at one end (leaves) and a single cluster containing every object at the other (root)."@en ;
  rdfs:subClassOf obo:OBI_0200175 .

obo:OBI_0600055 a rdfs:Class ;
  rdfs:label "DNA restriction enzyme digestion"@en ;
  rdfs:comment "A specific enzymatic cleavage of DNA molecules using endonucleases that cleave DNA molecules at specific sites based on the surrounding nucleotide sequence"@en ;
  rdfs:subClassOf obo:OBI_0600050 .

obo:OBI_0000573 a rdfs:Class ;
  rdfs:label "gradient pump system" ;
  rdfs:comment "A pump system optimized for gradient chromatography."@en ;
  rdfs:subClassOf obo:OBI_0000589 .

obo:NCBITaxon_131567 a rdfs:Class ;
  rdfs:label "cellular organism" ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0002066 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific granzyme B release by T cells" ;
  rdfs:comment "A detection of specific nucleic acids with complementary probes assay that detects epitope specific granzyme B release by T cells"@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001436 .

obo:OBI_0003157 a rdfs:Class ;
  rdfs:label "high-density lipoprotein cholesterol concentration assay" ;
  rdfs:comment "A high-density lipoprotein cholesterol assay that measures the concentration of high-density lipoprotein cholesterol in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100030 .

obo:OBI_0000972 a rdfs:Class ;
  rdfs:label "obsolete_electrically powered device" ;
  rdfs:comment "a processed material created to have a function and which requires electrical power to execute"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:IAO_8000003 a rdfs:Class ;
  rdfs:label "main release ontology module"@en ;
  rdfs:comment "An ontology module that is intended to be the primary release product and the one consumed by the majority of tools."@en ;
  rdfs:subClassOf obo:IAO_8000000 .

obo:OBI_2100337 a rdfs:Class ;
  rdfs:label "manual differential bodily fluid eosinophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of eosinophils in bodily fluid as part of a manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003023 .

obo:OBI_0001634 a rdfs:Class ;
  rdfs:label "calorimetric binding assay" ;
  rdfs:comment "A binding assay in which the heat generated or absorbed during a binding event is measured, which allows determination of binding constants, reaction stoichiometry, enthalpy and entropy."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0002797 a rdfs:Class ;
  rdfs:label "apron" ;
  rdfs:comment "A garment which is worn over other clothing and covers mainly the front of the body."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002760 a rdfs:Class ;
  rdfs:label "metatranscriptome profiling assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that determines the RNA sequence of microbial transcripts from a microbioal community of mixed species from a given microbiome."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0200105 a rdfs:Class ;
  rdfs:label "partial least square regression analysis"@en ;
  rdfs:comment """Partial least squares regression is an extension of the multiple linear regression model (see, e.g., Multiple Regression or General Stepwise Regression). In its simplest form, a linear model specifies the (linear) relationship between a dependent (response) variable Y, and a set of predictor variables, the X's, so that
Y = b0 + b1X1 + b2X2 + ... + bpXp
In this equation b0 is the regression coefficient for the intercept and the bi values are the regression coefficients (for variables 1 through p) computed from the data."""@en ;
  rdfs:subClassOf obo:OBI_0200102 .

obo:OBI_0003545 a rdfs:Class ;
  rdfs:label "ELISA measuring Chikungunya IgM antibody" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects the IgM antibody that binds Chikungunya."@en ;
  rdfs:subClassOf obo:OBI_0000661 .

obo:OBI_0002549 a rdfs:Class ;
  rdfs:label "ovary specimen" ;
  rdfs:comment "A specimen that is derived from female gonad."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_00001975 a rdfs:Class ;
  rdfs:label "chromatin immunoprecipitation"@en ;
  rdfs:comment "An immunoprecipitation in which chromatin (i.e. packaged DNA which can include protein and RNA complexes) is cut into short regions, reversibly cross linked, and antibodies or tags are used to select for pieces of chromatin with desired characteristics."@en ;
  rdfs:subClassOf obo:OBI_0000690 .

obo:OBI_0003622 a rdfs:Class ;
  rdfs:label "antibody purification of HLA protein complex with B27 serotype" ;
  rdfs:comment "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with B27 serotype, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003617 .

obo:GO_0004353 a rdfs:Class ;
  rdfs:label "L-glutamate dehydrogenase [NAD(P)+] activity" ;
  rdfs:comment "Catalysis of the reaction: L-glutamate + NAD(P)+ + H2O = 2-oxoglutarate + NH4+ + NAD(P)H + H+." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0003168 a rdfs:Class ;
  rdfs:label "potassium(1+) concentration assay" ;
  rdfs:comment "A potassium(1+) assay that measures the concentration of potassium(1+) in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100004 .

obo:OBI_0200182 a rdfs:Class ;
  rdfs:label "data vector reduction data transformation"@en ;
  rdfs:comment "A data vector reduction is a data transformation that has objective data vector reduction and that consists of reducing the input vectors k to a smaller number of output vectors j, where j<k."@en ;
  rdfs:subClassOf obo:OBI_0000707 .

obo:GO_0032638 a rdfs:Class ;
  rdfs:label "interleukin-9 production" ;
  rdfs:comment "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0002708 a rdfs:Class ;
  rdfs:label "insecticide resistance dose response assay" ;
  rdfs:comment "A direct insecticide resistance assay in which an insect population is exposed to a range of insecticide dosage scoring mortality to determine resistance."@en ;
  rdfs:subClassOf obo:OBI_0002705 .

obo:GO_0071604 a rdfs:Class ;
  rdfs:label "transforming growth factor beta production" ;
  rdfs:comment "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:UBERON_0000948 a rdfs:Class ;
  rdfs:label "heart" ;
  rdfs:comment "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0001573 a rdfs:Class ;
  rdfs:label "DNA sequence data" ;
  rdfs:comment "A sequence data item that is about the primary structure of DNA"@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001854 a rdfs:Class ;
  rdfs:label "protein and RNA interaction identification objective"@en ;
  rdfs:comment "A sequence feature identification objective that aims to characterize the interactions between protein and RNA."@en ;
  rdfs:subClassOf obo:OBI_0000113 .

obo:OBI_0002045 a rdfs:Class ;
  rdfs:label "polyA-site sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that quantitatively profiles RNA polyadenylation at the transcriptome level."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0000510 a rdfs:Class ;
  rdfs:label "reversed phase column" ;
  rdfs:comment "A reversed phase column is a chromatography column in which the mobile phase is more polar than the stationary phase. Its counterpart is the normal phase column."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0002012 a rdfs:Class ;
  rdfs:label "PacBio RS II" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Pacific Biosciences corporation. Built upon single molecule real-time sequencing technology, the machine is optimized for generation with long reads and high consensus accuracy."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0000894 a rdfs:Class ;
  rdfs:label "protein extract" ;
  rdfs:comment "a protein extract is the output of an extraction process from tissues or cell cultures resulting in a solution of cellular and/or organellar proteins in buffer solution used to prevent degradation,"@en ;
  rdfs:subClassOf obo:OBI_0000423 .

obo:OBI_0001334 a rdfs:Class ;
  rdfs:label "epitope specific granulocyte colony stimulating factor production by T cells" ;
  rdfs:comment "A process of granulocyte colony stimulating factor production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071611 , obo:OBI_0001193 .

obo:OBI_0001100 a rdfs:Class ;
  rdfs:label "microcentrifuge" ;
  rdfs:comment "A type of centrifuge that is designed for small tubes (0.2 ml to 2.0 ml), has a compact design, and has a small footprint."@en ;
  rdfs:subClassOf obo:OBI_0400106 .

obo:OBI_0001894 a rdfs:Class ;
  rdfs:label "email address of sequencing facility contact person"@en ;
  rdfs:comment "An email address of the contact representative at the sequencing facility"@en ;
  rdfs:subClassOf obo:IAO_0000429 .

obo:OBA_2060185 a rdfs:Class ;
  rdfs:label "facial muscle performance" ;
  rdfs:comment "The functionality of a facial muscle." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:OBI_0000923 a rdfs:Class ;
  rdfs:label "surface plasmon resonance binding assay" ;
  rdfs:comment "A binding assay that uses the detection of electromagnetic waves in a surface to detect material entities adsorbed to the surface, which change the local optical index of refraction."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0001818 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-X-C motif) ligand 12 production by T cells" ;
  rdfs:comment "A process of chemokine (C-X-C motif) ligand 12 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0097390 , obo:OBI_0001193 .

obo:OBI_0001940 a rdfs:Class ;
  rdfs:label "N50"@en ;
  rdfs:comment "the weighted median item size or N50 is a weighted median of the lengths of items, equal to the length of the longest item i such that the sum of the lengths of items greater than or equal in length to i is greater than or equal to half the length of all of the items. With regard to assemblies the items are typically contigs or scaffolds. It therefore denotes the ability of the software to create contigs and provides information about the resulting sequence assembly"@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:IAO_0000039 a rdf:Property ;
  rdfs:label "has measurement unit label"@en ;
  rdfs:range obo:IAO_0000003 , obo:UO_0000002 , obo:UO_0000095 , obo:UO_0000005 .

obo:OBI_0003686 a rdfs:Class ;
  rdfs:label "chromatin accessibility assay" ;
  rdfs:comment "An assay that determines which regions of a DNA molecule are in the form of euchromatin and thus able to make direct physical contact with (i.e. are accessible to) other molecules such as RNA polymerase, transcription factors, etc."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0302891 a rdfs:Class ;
  rdfs:label "trypsination"@en ;
  rdfs:comment "trypsination is a protease cleavage which uses enzyme trypsin to act on proteins present in an input material entity"@en ;
  rdfs:subClassOf obo:OBI_0600056 .

obo:OBI_0002685 a rdfs:Class ;
  rdfs:label "immunoelectrophoresis" ;
  rdfs:comment "An electrophoresis that separates and characterize proteins based on reaction with antibodies."@en ;
  rdfs:subClassOf obo:OBI_0600053 .

obo:RO_0000057 a rdf:Property ;
  rdfs:label "has participant"@en ;
  rdfs:comment "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_2100051 a rdfs:Class ;
  rdfs:label "3-hydroxybutyric acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of 3-hydroxybutyric acid"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003336 a rdfs:Class ;
  rdfs:label "functional magnetic resonance image data set" ;
  rdfs:comment "An magnetic resonance image data set collected as a 4D time series representing changes in brain metabolism (i.e. BOLD), typically used as a proxy for brain activity."@en ;
  rdfs:subClassOf obo:OBI_0003334 .

obo:OBI_0003430 a rdfs:Class ;
  rdfs:label "gamma-glutamyltransferase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of gamma-glutamyltransferase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0000558 a rdfs:Class ;
  rdfs:label "Varian UNITY INOVA spectrometer" ;
  rdfs:comment "The UNITY INOVA is also the easiest spectrometer to use and is also the choice of those interested in using advanced NMR techniques in their own research, but without becoming, or hiring, an NMR expert. A complete set of turnkey operating environments is available for the UNITY INOVA covering the structure and dynamics of biological macromolecules, small molecules, solids, and imaging. These packages put the combined NMR expertise of the entire Varian NMR community at your fingertips."@en ;
  rdfs:subClassOf obo:OBI_0000611 .

obo:OBI_2100257 a rdfs:Class ;
  rdfs:label "peak venous blood tobramycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of tobramycin in venous blood as part of a peak order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100045 .

obo:GO_0042611 a rdfs:Class ;
  rdfs:label "MHC protein complex" ;
  rdfs:comment "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." ;
  rdfs:subClassOf obo:GO_0032991 .

obo:OBI_2100287 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_2100033 a rdfs:Class ;
  rdfs:label "thyroid stimulating hormone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of thyroid stimulating hormone"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002077 a rdfs:Class ;
  rdfs:label "specimens derived from shared ancestor"@en ;
  rdfs:comment "A collection of specimens derived from one common specimen via one or more material processing process(es)."@en ;
  rdfs:subClassOf obo:OBI_0002076 .

obo:RO_0002351 a rdf:Property ;
  rdfs:label "has member"@en ;
  rdfs:comment "has member is a mereological relation between a collection and an item." ;
  rdfs:range obo:OBI_0100051 .

obo:OBI_0000591 a rdfs:Class ;
  rdfs:label "Bruker BEST NMR system" ;
  rdfs:comment "The introduction of biological screening and combinatorial chemistry for chemical synthesis has also introduced new requirements for NMR automation, e.g., the use of well plates for sample input, increased demands on throughput, and the need for quick and simple interpretation of the acquired NMR data."@en ;
  rdfs:subClassOf obo:OBI_0000464 .

obo:OBI_0001600 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific granulocyte colony stimulating factor production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects granulocyte colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002530 a rdfs:Class ;
  rdfs:label "adipose tissue specimen" ;
  rdfs:comment "A specimen that is derived from adipose tissue."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100383 a rdfs:Class ;
  rdfs:label "venous blood beta hydroxybutric acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of beta hydroxybutric acid in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100051 .

obo:OBI_0400153 a rdfs:Class ;
  rdfs:label "droplet sorter" ;
  rdfs:comment "A droplet sorter is part_of a flow cytometer sorter that converts the carrier fluid stream into individual droplets, and these droplets are directed into separate locations for recovery (enriching the original sample for particles of interest based on qualities determined by gating) or disposal."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0003520 a rdfs:Class ;
  rdfs:label "stance feet apart assessment" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet 20 cm apart."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0000446 a rdfs:Class ;
  rdfs:label "obsolete_identification" ;
  rdfs:comment "a process by which the identity (what a thing is) of a material entity is established within a certain confidence interval"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100073 a rdfs:Class ;
  rdfs:label "venous blood magnesium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of magnesium in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100021 .

obo:OBI_0002122 a rdfs:Class ;
  rdfs:label "major histocompatibility typing assay" ;
  rdfs:comment "A genotyping assay in which the alleles of genes encoding for major histocompatibility complex molecules are determined."@en ;
  rdfs:subClassOf obo:OBI_0000435 .

obo:OBI_0001922 a rdfs:Class ;
  rdfs:label "microRNA profiling by high throughput sequencing assay" ;
  rdfs:comment "A microRNA profiling assay that analyzes the microRNA component of the transcriptome using high throughput sequencing technology."@en ;
  rdfs:subClassOf obo:OBI_0001926 .

obo:PATO_0001985 a rdfs:Class ;
  rdfs:label "frozen" ;
  rdfs:comment "A quality inhering in a bearer by virtue of the bearer's being kept below its freezing point." ;
  rdfs:subClassOf obo:PATO_0000146 .

obo:OBI_0003620 a rdfs:Class ;
  rdfs:label "antibody purification of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype" ;
  rdfs:comment "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003617 .

obo:OBI_0001988 a rdfs:Class ;
  rdfs:label "assay measuring the dissociation constant [KD] of a MHC:ligand complex" ;
  rdfs:comment "A MHC binding constant determination assay measuring equilibrium dissociation constant (KD)."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001553 .

obo:PATO_0001792 a rdfs:Class ;
  rdfs:label "left side of" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's being located on left side of from the a another entity." ;
  rdfs:subClassOf obo:PATO_0000140 .

obo:OBI_0002555 a rdfs:Class ;
  rdfs:label "age group inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states an age bracket which, if met, makes an entity suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0002415 a rdfs:Class ;
  rdfs:label "exposure to environmental and workplace carcinogens history" ;
  rdfs:comment "An information content entity that indicates the exposure of an individual to carcinogens in the workplace or environment."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0001240 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-6 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-6 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001451 .

obo:OBI_0003041 a rdfs:Class ;
  rdfs:label "falcivax rapid diagnostic test" ;
  rdfs:comment "A parasite detection assay that can quickly establish the diagnosis of P. falciparum or P. vivax malaria infection by detecting the antigens in a person's blood."@en ;
  rdfs:subClassOf obo:OBI_0003038 , obo:OBI_0003040 .

obo:OBI_0200113 a rdfs:Class ;
  rdfs:label "similarity calculation"@en ;
  rdfs:comment "A similarity calculation is a data transformation that attaches to each pair of objects in the input a number that is meant to reflect how 'close' or 'similar' those objects are."@en ;
  rdfs:subClassOf obo:OBI_0000663 , obo:OBI_0200175 .

obo:OBI_0001420 a rdfs:Class ;
  rdfs:label "epitope specific helper T cell enhancement of T cell mediated immune response" ;
  rdfs:comment "A process of helper T cell enhancement of T cell mediated immune response resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0035398 .

obo:OBI_0001681 a rdfs:Class ;
  rdfs:label "yeast one-hybrid assay" ;
  rdfs:comment "An assay that determines protein DNA interactions using a single fusion protein in which the activating domain is linked directly to the binding domain."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0003560 a rdfs:Class ;
  rdfs:label "intra-amniotic administration" ;
  rdfs:comment "An administration of a substance into the amnion of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0002472 a rdfs:Class ;
  rdfs:label "dbGaP study identifier"@en ;
  rdfs:comment "A central registered identifier symbol that denotes a specific study in dbGaP."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:IAO_0000183 a rdfs:Class ;
  rdfs:label "dendrogram"@en ;
  rdfs:comment """A dendrogram is a report graph which is a tree diagram
frequently used to illustrate the arrangement of the clusters produced by a
clustering algorithm."""@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:OBI_0000486 a rdfs:Class ;
  rdfs:label "continuous wave NMR instrument" ;
  rdfs:comment "Continuous wave NMR spectrometers are similar to optical spectrometers, but the sample is held in a strong magnetic field, where the frequency of the source is slowly scanned (in some instruments, the source frequency is held constant, and the field is scanned)."@en ;
  rdfs:subClassOf obo:OBI_0000566 .

obo:OBI_0003344 a rdfs:Class ;
  rdfs:label "high resolution T1 weighted magnetic resonance image data set" ;
  rdfs:comment "A T1-weighted image data set acquired from an NMR/MRI machine with at least a 3 Tesla magnet and in which the voxel size is isotropic."@en ;
  rdfs:subClassOf obo:OBI_0003343 .

obo:OBI_0003001 a rdfs:Class ;
  rdfs:label "daytime arthropod specimen collection by aspiration" ;
  rdfs:comment "An arthropod specimen collection by aspiration that occurs in the daytime."@en ;
  rdfs:subClassOf obo:OBI_0002912 .

obo:COB_0000080 a rdfs:Class ;
  rdfs:label "complex of molecules"@en ;
  rdfs:comment "A complex of two or more molecules that are not covalently bound."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0500000 a rdfs:Class ;
  rdfs:label "study design"@en ;
  rdfs:comment "A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0002624 a rdfs:Class ;
  rdfs:label "case-control study design" ;
  rdfs:comment "A study design that entails the creation of two types of roles, such that each participant under investigation bears one or the other. What distinguishes the two types of roles is an 'outcome', which is associated with participants that have the case role but not associated with participants that have the control role. A case-control study examines the hypothesis that the presence of the outcome in case participants is associated with an 'exposure' that is not associated with control participants."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001083 a rdfs:Class ;
  rdfs:label "multichannel electronic pipette" ;
  rdfs:comment "A multichannel pipette that can be programmed by the user to aspirate a volume of liquid reagent or sample and dispense the aspirated volume or a series of aliquots in successive dispensing operations."@en ;
  rdfs:subClassOf obo:OBI_0001118 .

obo:OBI_2100290 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:GO_0097391 a rdfs:Class ;
  rdfs:label "chemokine (C-X-C motif) ligand 13 production" ;
  rdfs:comment "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0500005 a rdfs:Class ;
  rdfs:label "matched pairs design" ;
  rdfs:comment "A matched pair design is a study design which use groups of individuals associated (hence matched) to each other based on a set of criteria, one member going to one treatment, the other member receiving the other treatment."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001121 a rdfs:Class ;
  rdfs:label "gel electrophoresis system" ;
  rdfs:comment "An electrophoresis system in which an electric field is applied to a gel matrix"@en ;
  rdfs:subClassOf obo:OBI_0001053 .

obo:OBI_0003347 a rdfs:Class ;
  rdfs:label "T1 weighted SE magnetic resonance image data set" ;
  rdfs:comment "A T1 weighted image data set acquired using a spin echo sequence."@en ;
  rdfs:subClassOf obo:OBI_0003341 .

obo:COB_0000022 a rdfs:Class ;
  rdfs:label "organism"@en ;
  rdfs:comment "A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome"@en ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_2100156 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_0002023 a rdfs:Class ;
  rdfs:label "Human Genome U133 Plus 2.0 tiling array" ;
  rdfs:comment "A tiling array which is  a comprehensive whole human genome expression array manufactured by the Affymetrix corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 47,000 transcripts and variants."@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_2100258 a rdfs:Class ;
  rdfs:label "24 hour urine creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in urine as part of a 24 hour order"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100003 .

obo:OBI_0001523 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-17F production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-17F production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001296 , obo:OBI_0001772 , obo:OBI_0003115 .

obo:GO_1990505 a rdfs:Class ;
  rdfs:label "mitotic DNA replication maintenance of fidelity" ;
  rdfs:comment "Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication." ;
  rdfs:subClassOf obo:GO_0045005 .

obo:OBI_0001173 a rdfs:Class ;
  rdfs:label "service" ;
  rdfs:comment "A planned process in which a service provider performs a task (i.e. a planned process) for a service consumer."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002040 a rdfs:Class ;
  rdfs:label "chromatin isolation by RNA purification sequencing assay" ;
  rdfs:comment "A detection of specific nucleic acids with complementary probes assay that measures regions of the genome which are bound by a specific RNA (or a by a ribonucleoprotein containing the RNA of interest) using high-throughput sequencing."@en ;
  rdfs:subClassOf obo:OBI_0000874 .

obo:COB_0000122 a rdfs:Class ;
  rdfs:label "obsolete physical information carrier" .

obo:OBI_0002146 a rdfs:Class ;
  rdfs:label "HIV antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0003135 a rdfs:Class ;
  rdfs:label "zinc finger mediated mutagenesis" ;
  rdfs:comment "An endonuclease mediated mutagenesis in which synthetic zinc-finger proteins designed to target specific DNA sequences are used to introduce a mutation at a specific location in the genome."@en ;
  rdfs:subClassOf obo:OBI_0003132 .

obo:OBI_0002425 a rdfs:Class ;
  rdfs:label "radiation treatment exclusion criteria" ;
  rdfs:comment "An exclusion criterion that defines whether radiation was received or is being received for a previous  or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process"@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0003765 a rdfs:Class ;
  rdfs:label "pathological macroscopic examination of specimen assay" ;
  rdfs:comment "A macroscopic examination of material anatomical entity assay performed on a post-mortem anatomical specimen."@en ;
  rdfs:subClassOf obo:OBI_0003764 .

obo:OBI_0003088 a rdfs:Class ;
  rdfs:label "autofluorescence microscopy assay" ;
  rdfs:comment "An autofluorescence assay in which the light that is naturally emitted by a sample is visualized via microscopy after excitation of the sample with light at a suitable wavelength."@en ;
  rdfs:subClassOf obo:OBI_0003087 .

obo:OBI_0000994 a rdfs:Class ;
  rdfs:label "intravenous injection" ;
  rdfs:comment "is the injection of a material entity (bearing the administered substance role) into the vein (bearing the target role) of an organism using a syringe"@en ;
  rdfs:subClassOf obo:OBI_0000426 , obo:OBI_0600007 .

obo:PATO_0001632 a rdfs:Class ;
  rdfs:label "anterior to" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity." ;
  rdfs:subClassOf obo:PATO_0000140 .

obo:OBI_0002009 a rdfs:Class ;
  rdfs:label "Mouse 3x720K Whole Genome CGH Tiling Array" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for mouse DNA against 3x720,000 features."@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_0001656 a rdfs:Class ;
  rdfs:label "electron microscopy assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An electron microscopy imaging assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001631 , obo:OBI_0001703 .

obo:OBI_0003063 a rdfs:Class ;
  rdfs:label "insecticide resistance datum" ;
  rdfs:comment "A data item that is about resistance to an insecticide."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:PATO_0000169 a rdfs:Class ;
  rdfs:label "viability" ;
  rdfs:comment "An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population." ;
  rdfs:subClassOf obo:PATO_0001995 .

obo:OBI_0001872 a rdfs:Class ;
  rdfs:label "sequence assembly process"@en ;
  rdfs:comment "A data transformation that assembles two or more individual sequence reads into contiguous sequences (i.e., contigs)."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_0302838 a rdfs:Class ;
  rdfs:label "validated information"@en ;
  rdfs:comment "an information content entity which results from a validation process aimed at confirming a claim, a finding or a predicted information entity about a material entity or a process by experimental means."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_2100123 a rdfs:Class ;
  rdfs:label "arterial blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:GO_0042605 a rdfs:Class ;
  rdfs:label "peptide antigen binding" ;
  rdfs:comment "Binding to an antigen peptide." ;
  rdfs:subClassOf obo:GO_0003823 .

obo:OBI_0000207 a rdfs:Class ;
  rdfs:label "obsolete health care provider role" ;
  rdfs:comment "a worker role of providing medical care either within or outside the study timeline"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002088 a rdfs:Class ;
  rdfs:label "specimen container" ;
  rdfs:comment "A container with the function of containing a specimen."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0002656 a rdfs:Class ;
  rdfs:label "core needle biopsy" ;
  rdfs:comment "A biopsy that uses a hollow tube to collect a core of tissue."@en ;
  rdfs:subClassOf obo:OBI_0002654 .

obo:OBI_2100260 a rdfs:Class ;
  rdfs:label "total venous blood PSA assay" ;
  rdfs:comment "An analyte assay that measures the abundance of PSA in venous blood as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100034 .

obo:OBI_2100359 a rdfs:Class ;
  rdfs:label "venous blood osmolality assay" ;
  rdfs:comment "An assay that measures osmolality in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100039 .

obo:OBI_0002584 a rdfs:Class ;
  rdfs:label "differential expression analysis data" ;
  rdfs:comment "The results of a differential expression analysis."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:PATO_0002202 a rdfs:Class ;
  rdfs:label "left handedness" ;
  rdfs:comment "Handedness where the organism preferentially uses the left hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot." ;
  rdfs:subClassOf obo:PATO_0002201 .

obo:OBI_1110199 a rdfs:Class ;
  rdfs:label "epitope specific IL-4 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-4 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032633 , obo:OBI_0001193 .

obo:OBI_0001730 a rdfs:Class ;
  rdfs:label "surface plasmon resonance assay measuring the association constant [KA] of a B cell epitope:antibody complex" ;
  rdfs:comment "A surface plasmon resonance binding assay that measures the association constant [KA] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000923 , obo:OBI_0001719 .

obo:OBI_0001435 a rdfs:Class ;
  rdfs:label "DNA methylation profiling by high throughput sequencing design" ;
  rdfs:comment "A study design in which the methylation state of DNA is determined and is compared between samples using high throughput sequencing technology."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:UBERON_0001037 a rdfs:Class ;
  rdfs:label "strand of hair" ;
  rdfs:comment "A filament, mostly protein, that grows from follicles found in the dermis[WP]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_2100311 a rdfs:Class ;
  rdfs:label "POC arterial blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in arterial blood as part of a POC order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:OBI_0200064 a rdfs:Class ;
  rdfs:label "centroid mass spectrum analysis"@en ;
  rdfs:comment "A centroid mass spectrum is a data transformation in which many points are used to delineate a mass spectral peak, is converted into mass-centroided data by a data compression algorithm. The centroided mass peak is located at the weighted center of mass of the profile peak. The normalized area of the peak provides the mass intensity data."@en ;
  rdfs:subClassOf obo:OBI_0200085 .

obo:OBI_0000699 a rdfs:Class ;
  rdfs:label "survival assessment assay" ;
  rdfs:comment "An assay that measures the occurrence of death events in one or more organisms over time"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100179 a rdfs:Class ;
  rdfs:label "quantitative venous blood IgA assay" ;
  rdfs:comment "An assay that measures IgA in venous blood as part of a quantitative order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:PR_000001004 a rdfs:Class ;
  rdfs:label "CD4 molecule" ;
  rdfs:comment "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0002631 a rdfs:Class ;
  rdfs:label "single-cell transcription profiling by RNA sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that uses as input RNA extracts that can be traced to a single cell of origin. These extracts may come from the entire cell or only a part of the cell such as the nucleus or the cytoplasm."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0001551 a rdfs:Class ;
  rdfs:label "access service" ;
  rdfs:comment "A service in which a service consumer receives the right to use a resource (instrument, database, software, etc) that is owned or managed by a service provider.  Ownership of the accessed resource remains with the service provider during and after provision of service."@en ;
  rdfs:subClassOf obo:OBI_0001173 .

obo:GO_0032620 a rdfs:Class ;
  rdfs:label "interleukin-17 production" ;
  rdfs:comment "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0001017 a rdfs:Class ;
  rdfs:label "single-nucleotide-resolution nucleic acid structure mapping assay using chemical probing" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines structural information about the RNA species under study using small chemical compounds acting as chemical probes."@en ;
  rdfs:subClassOf obo:OBI_0000870 .

obo:OBI_0001768 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects chemokine (C-C motif) ligand 1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001276 .

obo:OBI_0000983 a rdfs:Class ;
  rdfs:label "intranasal mucosal administration" ;
  rdfs:comment "The administration of a substance into the intranasal mucosis of an organism"@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0000944 a rdfs:Class ;
  rdfs:label "handedness assay" ;
  rdfs:comment "An assay that measures the unequal distribution of fine motor skill between the left and right hands typically in human subjects by means of some questionnaire and scoring procedure."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002178 a rdfs:Class ;
  rdfs:label "whole-cell patch clamp assay" ;
  rdfs:comment "A patch-clamp assay where the electrode is left in place on the cell, as in cell-attached recordings, but the membrane patch has been perforated, providing access from the interior of the pipette to the intracellular space of the cell. Measurements made with this technique involve recording currents through multiple channels simultaneously, over the membrane of the entire cell."@en ;
  rdfs:subClassOf obo:OBI_0002177 .

obo:UBERON_0001155 a rdfs:Class ;
  rdfs:label "colon" ;
  rdfs:comment "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0002688 a rdfs:Class ;
  rdfs:label "loop-mediated isothermal amplification" ;
  rdfs:comment "An enzymatic amplification in which a piece of DNA is amplified at a constant temperature of 60 - 65 degree C using either two or three sets of primers and a polymerase with high strand displacement activity in addition to a replication activity. This amplification does not need thermal cyclers and may be a low cost alternative to PCR."@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBI_0003404 a rdfs:Class ;
  rdfs:label "Affymetrix Human Exon Junction Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, used to identify exon-exon junctions associated with alternate splice variants in the human transcriptome."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0001832 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-17F production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-17F production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001291 , obo:OBI_0001772 .

obo:OBI_0600057 a rdfs:Class ;
  rdfs:label "enzymatic DNA replication"@en ;
  rdfs:comment "the use of enzymes to duplicate DNA molecule any process used to make additional copies of a biomaterial"@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBI_0003574 a rdfs:Class ;
  rdfs:label "intrasplenic administration" ;
  rdfs:comment "An administration of a substance into the spleen of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_1110032 a rdfs:Class ;
  rdfs:label "HeLa cell line"@en ;
  rdfs:comment "A cell line derived from human cervical cancer cells."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0000730 a rdfs:Class ;
  rdfs:label "pyrosequencing assay" ;
  rdfs:comment "A DNA sequencing by synthesis assay which sequences a single strand of DNA by synthesizing the complementary strand along it, one base pair at a time, and detecting which base was actually added at each step. The template DNA is immobilized, and solutions of A, C, G, and T nucleotides are added and removed after the reaction, sequentially. Light is produced only when the nucleotide solution complements the first unpaired base of the template. The sequence of solutions which produce chemiluminescent signals allows the determination of the sequence of the template. ssDNA template is hybridized to a sequencing primer and incubated with the enzymes DNA polymerase, ATP sulfurylase, luciferase and apyrase, and with the substrates adenosine 5-prime phosphosulfate (APS) and luciferin."@en ;
  rdfs:subClassOf obo:OBI_0000734 .

obo:UBERON_3000016 a rdfs:Class ;
  rdfs:label "anterior nasal wall" ;
  rdfs:comment "Paired, vertical, and relatively straight plates that form the anterior limit of the nasal capsule." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0002719 a rdfs:Class ;
  rdfs:label "insecticide resistance by amplification refractory mutation system assay" ;
  rdfs:comment "An insecticide resistance by monitoring known mutations assay that detects any mutation involving single base changes or small deletions using amplification refractory mutation system (ARMS). The ARMS is based on the use of sequence-specific PCR primers that allow amplification of test DNA only when the target allele is contained within the sample. Following an ARMS reaction the presence or absence of a PCR product is diagnostic for the presence or absence of the target allele. It can be used to analyze human genomic DNA for one or more mutations."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0002696 .

obo:OBI_0200136 a rdfs:Class ;
  rdfs:label "edge betweenness calculation"@en ;
  rdfs:comment "An edge quality calculation in which the input is a data sets of shortest paths between all pairs of node in the network and the output is the sum of all shortest paths that traverse the specific edge."@en ;
  rdfs:subClassOf obo:OBI_0200135 .

obo:COB_0000011 a rdfs:Class ;
  rdfs:label "atom"@en ;
  rdfs:comment "A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:COB_0000800 a rdf:Property ;
  rdfs:label "has atomic number"@en ;
  rdfs:comment "Number of protons in an atomic nucleus"@en ;
  rdfs:domain obo:COB_0000011 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0002034 a rdfs:Class ;
  rdfs:label "transcript leader sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that combines enzymatic capture of m(7)G-capped mRNA 5' ends with high-throughput sequencing."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0000034 a rdfs:Class ;
  rdfs:label "supernatant role"@en ;
  rdfs:comment "supernatant role is a role which inheres in a material entity and is realized by a material separation process using gravitational force in which the material bearing the supernatant role is the liquid component of the output material."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:NCBITaxon_1206794 a rdfs:Class ;
  rdfs:label "Ecdysozoa" ;
  rdfs:subClassOf obo:NCBITaxon_33213 .

obo:OBI_0001554 a rdfs:Class ;
  rdfs:label "rate measurement datum" ;
  rdfs:comment "A scalar measurement datum that represents the number of events occuring over a time interval"@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0003593 a rdfs:Class ;
  rdfs:label "physician's global assessment of disease activity"@en ;
  rdfs:comment "A clinical data item that quantifies a physician's judgement of the overall activity of some specific disease in a patient."@en ;
  rdfs:subClassOf obo:OGMS_0000123 .

obo:IAO_0000422 a rdfs:Class ;
  rdfs:label "postal address"@en ;
  rdfs:comment "A textual entity that is used as directive to deliver something to a person, or organization" ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:PATO_0001342 a rdfs:Class ;
  rdfs:label "Saccharomyces cerevisiae mating type" ;
  rdfs:comment "A S. cerevisiae mating type." ;
  rdfs:subClassOf obo:PATO_0001337 .

obo:OBI_0002130 a rdfs:Class ;
  rdfs:label "Illumina Infinium Omni5Exome-4 Kit" ;
  rdfs:comment "An Illumina BeadChip which is an array that interrogates over 4.3 million whole-genome variants for genotyping and copy number variation."@en ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:OBI_0003266 a rdfs:Class ;
  rdfs:label "virus in feces datum" ;
  rdfs:comment "A feces microbiology datum that is about a virus."@en ;
  rdfs:subClassOf obo:OBI_0003246 .

obo:OGMS_0000123 a rdfs:Class ;
  rdfs:label "clinical data item"@en ;
  rdfs:comment "A data item that is about a patient and is the specified output of a health care process assay or diagnostic process" ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:NCBITaxon_314146 a rdfs:Class ;
  rdfs:label "Euarchontoglires" ;
  rdfs:subClassOf obo:NCBITaxon_40674 .

obo:OBI_0001843 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes measuring epitope specific interleukin-15 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-15 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001292 .

obo:OBI_0001461 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific granzyme B release by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects epitope specific granzyme B release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001436 .

obo:OBI_0003534 a rdfs:Class ;
  rdfs:label "upright stability assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to maintain upright body posture."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:CL_0000842 a rdfs:Class ;
  rdfs:label "mononuclear leukocyte" ;
  rdfs:comment "A leukocyte with a single non-segmented nucleus in the mature form." ;
  rdfs:subClassOf obo:CL_0000738 .

obo:GO_0006974 a rdfs:Class ;
  rdfs:label "DNA damage response" ;
  rdfs:comment "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." ;
  rdfs:subClassOf obo:GO_0050896 .

obo:OBI_0000544 a rdfs:Class ;
  rdfs:label "Bruker SampleRail system" ;
  rdfs:comment "This Instrument system automatically prepares an NMR sample, inserts it into an NMR magnet, performs NMR experiments on the sample, and transports it back to the preparation system.   The SampleRail fulfills the transporting tasks from the preparation system into the NMR magnet and back."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002573 a rdfs:Class ;
  rdfs:label "polyA depleted RNA extract" ;
  rdfs:comment "A RNA extract that is the output of an extraction process in which RNA molecules lacking poly A tails at thier 3' ends are purified."@en ;
  rdfs:subClassOf obo:OBI_0000880 .

obo:OBI_2100329 a rdfs:Class ;
  rdfs:label "bodily fluid glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in bodily fluid"@en ;
  rdfs:subClassOf obo:OBI_2100020 .

obo:OBI_0001033 a rdfs:Class ;
  rdfs:label "perturbation device" ;
  rdfs:comment "A perturbation device is a device which is designed to perform a perturb function"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001280 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001680 a rdfs:Class ;
  rdfs:label "Sos-recruitment assay" ;
  rdfs:comment "A binding assay that detects interacting proteins for a targeted domain where mammalian guanyl nucleotide exchange factor (GEF) Sos is recruited to the Saccharomyces cerevisiae plasma membrane harboring a temperature-sensitive Ras GEF, Cdc25-2, allowing growth at the nonpermissive temperature using the Sos recruitment system, a kind of yeast 2 hybrid system."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:CL_0000789 a rdfs:Class ;
  rdfs:label "alpha-beta T cell" ;
  rdfs:comment "A T cell that expresses an alpha-beta T cell receptor complex." ;
  rdfs:subClassOf obo:CL_0000084 .

obo:GO_0003823 a rdfs:Class ;
  rdfs:label "antigen binding" ;
  rdfs:comment "Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell." ;
  rdfs:subClassOf obo:GO_0003674 .

obo:OBI_0200194 a rdfs:Class ;
  rdfs:label "survival analysis data transformation" ;
  rdfs:comment "A data transformation which has the objective of performing survival analysis."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0002426 a rdfs:Class ;
  rdfs:label "chemotherapy treatment within the recent past exclusion criterion" ;
  rdfs:comment "An exclusion criterion that defines whether chemotherapy was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0001370 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects chemokine (C-C motif) ligand 4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001345 .

obo:OBI_0002454 a rdfs:Class ;
  rdfs:label "clinically relevant lifestyle inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states one or more clinically relevant planned processes that a human being actively participates in , which, if met, makes the human being suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:CHEBI_29191 a rdfs:Class ;
  rdfs:label "hydroxyl" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000931 a rdfs:Class ;
  rdfs:label "study intervention" ;
  rdfs:comment "A planned process that is the part of the execution of an intervention design study which is varied between two or more subjects in the study."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000792 a rdfs:Class ;
  rdfs:label "statistical model validation" ;
  rdfs:comment "A data transformation which assesses how the results of a statistical analysis will generalize to an independent data set."@en ;
  rdfs:subClassOf obo:OBI_0200171 .

obo:UBERON_0000173 a rdfs:Class ;
  rdfs:label "amniotic fluid" ;
  rdfs:comment "Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OBI_1110024 a rdfs:Class ;
  rdfs:label "environmental exposure to infectious agent"@en ;
  rdfs:comment "Is a process in which an infectious agent is in direct contact with a potential host organism in its habitat. This is preceded by proximity to the infectious agent"@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:RO_0002087 a rdf:Property ;
  rdfs:label "immediately preceded by"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0001911 a rdfs:Class ;
  rdfs:label "cell line culture"@en ;
  rdfs:comment "A cell culture comprised of cell line cells and the media in which they are being actively propagated or quiescently stored."@en ;
  rdfs:subClassOf obo:OBI_0001876 .

obo:OBI_2100345 a rdfs:Class ;
  rdfs:label "bodily fluid cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of cells in bodily fluid"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002119 a rdfs:Class ;
  rdfs:label "microscopy assay" ;
  rdfs:comment "An imaging assay that utilizes a microscope to magnify features of the visualized material of interest that are not visible to naked eye."@en ;
  rdfs:subClassOf obo:OBI_0000185 .

obo:CHEBI_17026 a rdfs:Class ;
  rdfs:label "progesterone" ;
  rdfs:comment "A C<small><sub>21</sub></small>-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0302887 a rdfs:Class ;
  rdfs:label "staining"@en ;
  rdfs:comment "Staining is a process which results in the addition a class-specific (DNA, proteins, lipids, carbohydrates) dye to a substrate to qualify or quantify the presence of a specific compound."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_1000023 a rdfs:Class ;
  rdfs:label "cell culture supernatant"@en ;
  rdfs:comment "Supernatant of a cell culture is a material entity which contains media, supplements, and secreted products of the cells and becomes the environment of cultivated cell."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003250 a rdfs:Class ;
  rdfs:label "biomedical laboratory organization"@en ;
  rdfs:comment "An organization that performs assays, processes specimens, analyses data and conducts planned processes relevant to the life sciences."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0001688 a rdf:Property ;
  rdfs:label "has organization member"@en ;
  rdfs:comment "Relating an organization to a legal person or organization."@en ;
  rdfs:domain obo:OBI_0000245 ;
  rdfs:range xsd:string .

obo:OBI_0000846 a rdf:Property ;
  rdfs:label "is member of organization" ;
  rdfs:comment "Relating a legal person or organization to an organization in the case where the legal person or organization has a role as member of the organization."@en ;
  rdfs:range obo:OBI_0000245 .

obo:OBI_0001565 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring half life to determine direct binding of a cell-lysate-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures half life to detect the direct binding of a cell-lysate-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001990 .

obo:NCBITaxon_3044472 a rdfs:Class ;
  rdfs:label "Orthoherpesviridae" ;
  rdfs:subClassOf obo:NCBITaxon_10239 .

obo:OBI_0001597 a rdfs:Class ;
  rdfs:label "cell bound MHC competitive binding assay measuring half maximal inhibitory concentration [IC50] of a MHC:ligand complex using T cell epitope recognition" ;
  rdfs:comment "A cell bound MHC ligand binding half maximal inhibitory concentration (IC50) determination assay that uses a T cell epitope recognition assay to measure ligand binding."@en ;
  rdfs:subClassOf obo:OBI_0001992 .

obo:PATO_0001546 a rdfs:Class ;
  rdfs:label "quality of a solid" ;
  rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable." ;
  rdfs:subClassOf obo:PATO_0002198 .

obo:OBI_0003553 a rdfs:Class ;
  rdfs:label "intragastric administration" ;
  rdfs:comment "An administration of a substance into the stomach of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_1110204 a rdfs:Class ;
  rdfs:label "epitope specific killing by T cells"@en ;
  rdfs:comment "A biological process where T cells lyse antigen presenting cells resulting from the recognition of a T cell epitope on MHC molecules of the antigen presenting cell."@en ;
  rdfs:subClassOf obo:GO_0001913 .

obo:OBI_0002945 a rdfs:Class ;
  rdfs:label "population based design" ;
  rdfs:comment "A study design where the selection of the individuals that are included into the study are intended to be representative of all individuals in the a priori defined specific population and is done at the population level or among the population groups, generally to find the cause, incidence or spread of the disease or to see the response to the treatment, nutrition or environment."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:CL_0000558 a rdfs:Class ;
  rdfs:label "reticulocyte" ;
  rdfs:comment "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_2100145 a rdfs:Class ;
  rdfs:label "electrolytes urine potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in urine as part of a electrolytes order"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100004 .

obo:OBI_0000384 a rdfs:Class ;
  rdfs:label "electricity supply function"@en ;
  rdfs:comment "An electricity supply function is an energy supply function to transfer electricity from one source to another, typically a consumer of the electricity or as a stimulus during a neuroscience experiment."@en ;
  rdfs:subClassOf obo:OBI_0000391 .

obo:CHEBI_51602 a rdfs:Class ;
  rdfs:label "resorufin" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0200075 a rdfs:Class ;
  rdfs:label "row submatrix extraction"@en ;
  rdfs:comment "A row submatrix extraction is a submatrix extraction where all the columns of the input matrix are retained and selection only occurs on the rows."@en ;
  rdfs:subClassOf obo:OBI_0200074 .

obo:OBI_0001651 a rdfs:Class ;
  rdfs:label "plasmon resonance assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A surface plasmon resonance binding assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000923 , obo:OBI_0001703 .

obo:OBI_0001081 a rdfs:Class ;
  rdfs:label "gel imaging system" ;
  rdfs:comment "A device that is used to acquire images of laboratory gels."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0000318 a rdfs:Class ;
  rdfs:label "eluate"@en ;
  rdfs:comment "a eluate is a material entity which results from an elution, e.g. from a chromatography column. it has as part a material entity with role mobile phase"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000920 a rdfs:Class ;
  rdfs:label "cytometric bead array assay" ;
  rdfs:comment "An analyte assay in which a series of beads coated with antibodies, antigens, or other small molecules are used to detect an analyte of interest."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:UBERON_0000162 a rdfs:Class ;
  rdfs:label "cloaca" ;
  rdfs:comment "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0002822 a rdfs:Class ;
  rdfs:label "drag swab" ;
  rdfs:comment "A specimen collection device consisting of a specimen pad made of sterile gauze which is aseptically attached to a pole by clips or to a string"@en ;
  rdfs:subClassOf obo:OBI_0002814 .

obo:GO_0021700 a rdfs:Class ;
  rdfs:label "developmental maturation" ;
  rdfs:comment "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:PATO_0103000 a rdfs:Class ;
  rdfs:label "quantitative" ;
  rdfs:comment "A quality of an entity that can be represented numerically, including anything that can be counted, measured, or given a numerical value." ;
  rdfs:subClassOf obo:PATO_0000001 .

obo:OBI_0002595 a rdfs:Class ;
  rdfs:label "enzymatic reaction identification design" ;
  rdfs:comment "A direct interaction identification design that investigations a biological reaction on a molecule which has been triggered by an enzyme."@en ;
  rdfs:subClassOf obo:OBI_0002594 .

obo:OBI_0003017 a rdfs:Class ;
  rdfs:label "metamyelocyte assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of metamyelocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:CL_0000576 a rdfs:Class ;
  rdfs:label "monocyte" ;
  rdfs:comment "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ;
  rdfs:subClassOf obo:CL_0000842 .

obo:OBI_0003756 a rdfs:Class ;
  rdfs:label "PIG-a assay" ;
  rdfs:comment "A cell based DNA damage assay in eukaryotic cells that detects loss of function through mutation of the X-linked (single-copy) Pig-a gene."@en ;
  rdfs:subClassOf obo:OBI_0003721 .

obo:OBI_0001204 a rdfs:Class ;
  rdfs:label "SNP microarray" ;
  rdfs:comment "A DNA microarray used to detect polymorphisms in DNA samples"@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:PATO_0000117 a rdfs:Class ;
  rdfs:label "size" ;
  rdfs:comment "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." ;
  rdfs:subClassOf obo:PATO_0000051 .

obo:FOODON_00002147 a rdfs:Class ;
  rdfs:label "food material by consumer group"@en ;
  rdfs:subClassOf obo:FOODON_00002403 .

obo:OBI_1110061 a rdfs:Class ;
  rdfs:label "exposure resulting in immune reactivity"@en ;
  rdfs:comment "a process in which an organism (host) is exposed to some material entity, which results in an immune reactivity"@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:GO_0006909 a rdfs:Class ;
  rdfs:label "phagocytosis" ;
  rdfs:comment "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001699 a rdfs:Class ;
  rdfs:label "antibody cross-blocking assay" ;
  rdfs:comment "A competitive inhibition of binding assay in which two antibodies that are known to bind the same antigen are tested for the ability of one antibody to inhibit binding of the other antibody to the antigen, thereby determining if they have overlapping binding sites."@en ;
  rdfs:subClassOf obo:OBI_0001593 .

obo:OBI_0003437 a rdfs:Class ;
  rdfs:label "ribonuclease activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of ribonuclease in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0200193 a rdfs:Class ;
  rdfs:label "background corrected data visualization" ;
  rdfs:comment "A data visualization which has input of a background corrected data set and produces an output of a report graph which is capable of rendering data of this type."@en ;
  rdfs:subClassOf obo:OBI_0200111 .

obo:OBI_2100062 a rdfs:Class ;
  rdfs:label "CBC with automated differential venous blood RBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of RBCs in venous blood as part of a CBC with automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_2100390 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid lymphocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of lymphocytes in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003024 , obo:OBI_0003232 .

obo:OBI_0003384 a rdfs:Class ;
  rdfs:label "synaptosome preparation process"@en ;
  rdfs:comment "A material component separation process where a synaptic terminal is isolated from a neuron by mild homogenization of nervous tissue under isotonic conditions and subsequent fractionation using differential and density gradient centrifugation."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:GO_0001913 a rdfs:Class ;
  rdfs:label "T cell mediated cytotoxicity" ;
  rdfs:comment "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." ;
  rdfs:subClassOf obo:GO_0001906 .

obo:OBI_0003164 a rdfs:Class ;
  rdfs:label "monocyte percentage assay" ;
  rdfs:comment "A monocyte assay that measures the percentage of monocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003025 .

obo:GO_0048869 a rdfs:Class ;
  rdfs:label "cellular developmental process" ;
  rdfs:comment "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001178 a rdfs:Class ;
  rdfs:label "efficacy of epitope intervention experiment" ;
  rdfs:comment "An assay that tests  if inducing an epitope specific immune response in an organism has an effect, such as the ability to prevent, treat or exacerbate diseases in the organism."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001883 a rdfs:Class ;
  rdfs:label "Bioinformatics Resource Center contact person"@en ;
  rdfs:comment "A person who is the contact representative of a Bioinformatics Resource Center"@en ;
  rdfs:subClassOf obo:NCBITaxon_9606 .

obo:OBI_0200120 a rdfs:Class ;
  rdfs:label "variance calculation"@en ;
  rdfs:comment "A variance calculation is a descriptive statistics calculation in which the variance is defined as the average squared distance of each observation in the data set to the mean of the data set.  It is also known as the second central moment."@en ;
  rdfs:subClassOf obo:OBI_0200086 , obo:OBI_0200184 .

obo:OBI_0001562 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-17F production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-17F production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001772 , obo:OBI_1110178 .

obo:OBI_0001662 a rdfs:Class ;
  rdfs:label "NMR assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope qualitative binding to antibody assay that uses a nuclear magnetic resonance assay."@en ;
  rdfs:subClassOf obo:OBI_0001703 .

obo:OBI_0003556 a rdfs:Class ;
  rdfs:label "topical administration" ;
  rdfs:comment "An administration of a substance onto the surface of the skin of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0002505 a rdfs:Class ;
  rdfs:label "milk specimen" ;
  rdfs:comment "A specimen that is derived from milk."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0003124 a rdfs:Class ;
  rdfs:label "neuron morphology assay" ;
  rdfs:comment "A 3D neural cell structure determination assay that determines the 3-dimensional configuration of a neuron."@en ;
  rdfs:subClassOf obo:OBI_0003123 .

obo:UBERON_0002046 a rdfs:Class ;
  rdfs:label "thyroid gland" ;
  rdfs:comment "A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]." ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:OBI_0003542 a rdfs:Class ;
  rdfs:label "microarray assay measuring Dengue IgM antibody" ;
  rdfs:comment "A microarray assay that detects the IgM antibody that binds Dengue."@en ;
  rdfs:subClassOf obo:OBI_0001985 .

obo:OBI_0000395 a rdfs:Class ;
  rdfs:label "signal amplification function"@en ;
  rdfs:comment "A signal amplification function is a signal conversion function to inject energy into an input signal so as to produce an output signal with increased differential magnitude while also seeking to minimize increases in the signal to noise ratio. For example, to produce a 0.1 KW output signal from a 1 mW RMS input signal."@en ;
  rdfs:subClassOf obo:OBI_0000393 .

obo:OBI_0001746 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-1 alpha production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001388 .

obo:OBI_0000955 a rdfs:Class ;
  rdfs:label "electrode puller" ;
  rdfs:comment "A device used in the first step in making electrodes, that applies constant tension on a glass capillary tube and eventually breaks it while heating it; this produces a very fine point on the capillary tube."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:GO_0030041 a rdfs:Class ;
  rdfs:label "actin filament polymerization" ;
  rdfs:comment "Assembly of actin filaments by the addition of actin monomers to a filament." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0002898 a rdfs:Class ;
  rdfs:label "cluster study group role" ;
  rdfs:comment "A study group role that is the result of the allocation of a cluster of study-defined groupings of people in a clinical trial to receive a specific intervention/treatment, or no intervention, according to the trial's protocol."@en ;
  rdfs:subClassOf obo:OBI_0000174 .

obo:OBI_0000674 a rdfs:Class ;
  rdfs:label "center value"@en ;
  rdfs:comment "A data item that is produced as the output of a center calculation data transformation and represents the center value of the input data."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0600011 a rdfs:Class ;
  rdfs:label "acclimatization"@en ;
  rdfs:comment "A protocol application in which an object is left in an environment for some period of time, until some qualities of interest are in equilibrium with that environment."@en ;
  rdfs:subClassOf obo:OBI_0600009 .

obo:OBI_0000467 a rdfs:Class ;
  rdfs:label "Bruker US 2 NMR magnet" ;
  rdfs:comment "An actively-shielded superconducting magnet from Bruker that combines Bruker BioSpin's advanced, proprietary UltraShield active shielding and UltraStabilized sub-cooling technologies. This shielded and stabilized (US2) magnet system delivers high sensitivity and spectral dispersion."@en ;
  rdfs:subClassOf obo:OBI_0000597 .

obo:OBI_1000049 a rdfs:Class ;
  rdfs:label "whole mount tissue" ;
  rdfs:comment "A whole organism preparation resulting from a histological preparation known as whole mount preparation where the whole specimen is mounted or spread on the microscope (glass) slide"@en ;
  rdfs:subClassOf obo:OBI_0000680 .

obo:OBI_0001167 a rdfs:Class ;
  rdfs:label "age measurement datum"@en ;
  rdfs:comment "A time measurement datum that is the result of measurement of age of an organism"@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0000981 a rdfs:Class ;
  rdfs:label "agar stab specimen" ;
  rdfs:comment "a specimen that is output of a process that cell culture inoculated into agar for long term storage."@en ;
  rdfs:subClassOf obo:OBI_0001472 , obo:OBI_0100051 .

obo:OBI_0001050 a rdfs:Class ;
  rdfs:label "RNA extraction/purification instrument" ;
  rdfs:comment "A device that is used to isolate and collect RNA for subsequent molecular analysis."@en ;
  rdfs:subClassOf obo:OBI_0001114 .

obo:OBI_0002476 a rdfs:Class ;
  rdfs:label "number of rounds of amplification"@en ;
  rdfs:comment "A data item that is the number of times an amplification reaction happened."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002163 a rdfs:Class ;
  rdfs:label "DNAse footprinting assay" ;
  rdfs:comment "An enzymatic footprinting assay that determines protein-binding sites on DNA by identifying bound fragments that are protected from DNAse I-catalyzed hydrolysis"@en ;
  rdfs:subClassOf obo:OBI_0002162 .

obo:OBI_0001983 a rdfs:Class ;
  rdfs:label "tolerance induction intervention experiment" ;
  rdfs:comment "An in vivo intervention experiment that tests the ability of the intervention to decrease an immune response."@en ;
  rdfs:subClassOf obo:OBI_0001980 .

obo:GO_0097388 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 19 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_2100211 a rdfs:Class ;
  rdfs:label "trough venous blood vancomycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of vancomycin in venous blood as part of a trough order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100044 .

obo:NCBITaxon_784 a rdfs:Class ;
  rdfs:label "Orientia tsutsugamushi" ;
  rdfs:subClassOf obo:NCBITaxon_3379134 .

obo:OBI_0001814 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-27 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-27 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001198 .

obo:OBI_0002112 a rdfs:Class ;
  rdfs:label "small RNA sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay which is targeting small RNA (< 200 bp) sequences such as, but not exclusive to, miRNAs using, for example, small RNA library preparation kits."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:UBERON_0000178 a rdfs:Class ;
  rdfs:label "blood" ;
  rdfs:comment "A fluid that is composed of blood plasma and erythrocytes." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_2100275 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0002461 a rdfs:Class ;
  rdfs:label "BCL format"@en ;
  rdfs:comment "A data format specification that is a binary file containing base calling data. These files are created by sequencing machines during the act of sequencing, and contain data about each of the nucleotide clusters on a sequencing flow cell."@en ;
  rdfs:subClassOf obo:IAO_0000098 .

obo:OBI_0000457 a rdfs:Class ;
  rdfs:label "manufacturing"@en ;
  rdfs:comment "A planned process with the objective to produce a processed material which will have a function for future use."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002368 a rdfs:Class ;
  rdfs:label "clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0200168 a rdfs:Class ;
  rdfs:label "correction objective"@en ;
  rdfs:comment "A correction objective is a data transformation objective where the aim is to correct for error, noise or other impairments to the input of the data transformation or derived from the data transformation itself"@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_1110050 a rdfs:Class ;
  rdfs:label "cultured CD4- T cell population"@en ;
  rdfs:comment "A T cell population characterized by not expressing the CD4 molecule on its surface."@en ;
  rdfs:subClassOf obo:OBI_0001875 .

obo:OBI_0002533 a rdfs:Class ;
  rdfs:label "colon specimen" ;
  rdfs:comment "A specimen that is derived from colon."@en ;
  rdfs:subClassOf obo:OBI_0003483 .

obo:OBI_0003378 a rdfs:Class ;
  rdfs:label "switching mechanism at the 5' end of RNA template sequencing assay" ;
  rdfs:comment "A single cell transcription profiling by RNA sequencing assay wherein cells are lysed and their recovered RNA is hybridized to an oligo(dT) that primes a reverse transcription reaction, the outcome of which are cDNA’s that have PCR handles on both ends. The cDNA's are then amplified using PCR, and the products are sequenced."@en ;
  rdfs:subClassOf obo:OBI_0002631 .

obo:OBI_0003650 a rdfs:Class ;
  rdfs:label "Illumina Infinium MethylationEPIC v2.0 BeadChip" ;
  rdfs:comment "An Illumina methylation BeadChip that targets  935,000 methylation sites per sample at single-nucleotide resolution."@en ;
  rdfs:subClassOf obo:OBI_0001870 .

obo:CLO_0009828 a rdfs:Class ;
  rdfs:label "immortal cell line"@en ;
  rdfs:comment "A cell line that is expected to be capable of indefinite propagation in an vitro culture." ;
  rdfs:subClassOf obo:CLO_0000031 .

obo:UBERON_0001729 a rdfs:Class ;
  rdfs:label "oropharynx" ;
  rdfs:comment "The portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0666667 a rdfs:Class ;
  rdfs:label "nucleic acid extraction"@en ;
  rdfs:comment "a material separation to recover the nucleic acid fraction of an input material"@en ;
  rdfs:subClassOf obo:OBI_0302884 .

obo:OBI_0200125 a rdfs:Class ;
  rdfs:label "data combination"@en ;
  rdfs:comment "A data transformation in which individual input data elements and values are merged together into a output set of data elements and values."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_2100081 a rdfs:Class ;
  rdfs:label "liver evaluation venous blood globulin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of globulin in venous blood as part of a liver evaluation order"@en ;
  rdfs:subClassOf obo:OBI_0003015 , obo:OBI_0003040 .

obo:GO_0004069 a rdfs:Class ;
  rdfs:label "L-aspartate:2-oxoglutarate transaminase activity" ;
  rdfs:comment "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:IAO_8000000 a rdfs:Class ;
  rdfs:label "ontology module"@en ;
  rdfs:subClassOf obo:IAO_0000102 .

obo:OBI_0002667 a rdfs:Class ;
  rdfs:label "in vivo skin test assay measuring T cell epitope specific type IV hypersensitivity resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that detects epitope specific type IV hypersensitivity after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0001178 , obo:OBI_0001348 , obo:OBI_0002676 .

obo:OBI_0003210 a rdfs:Class ;
  rdfs:label "nitrite assay" ;
  rdfs:comment "An analyte assay that measures the abundance of nitrite"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_2100022 a rdfs:Class ;
  rdfs:label "albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:OBI_0001244 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-23 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-23 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001363 .

obo:OBI_0000961 a rdfs:Class ;
  rdfs:label "addition of molecular tracer function" ;
  rdfs:comment "A reagent application function that is realized when a molecular tracer, such as an antibody or probe is automatically transferred to a biological specimen."@en ;
  rdfs:subClassOf obo:OBI_0000960 .

obo:OBI_0001259 a rdfs:Class ;
  rdfs:label "translational bias design" ;
  rdfs:comment "A study design that characterizes the association of transcripts and translation machinery."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003851 a rdfs:Class ;
  rdfs:label "growth factor assay" ;
  rdfs:comment "An analyte assay to measure the abundance of one or more growth factors in a volume of sample."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002096 a rdfs:Class ;
  rdfs:label "carboxyfluorescein succinimidyl ester staining assay measuring epitope specific proliferation of T cells" ;
  rdfs:comment "A CFSE assay that detects T cell epitope specific proliferation in vitro."@en ;
  rdfs:subClassOf obo:OBI_0002071 , obo:OBI_0002106 .

obo:OBI_0000497 a rdfs:Class ;
  rdfs:label "sample inlet" ;
  rdfs:comment "The column inlet (or injector) provides the means to introduce a sample into a continuous flow of carrier gas. The inlet is a piece of hardware attached to the column head."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0000797 a rdfs:Class ;
  rdfs:label "obsolete_primary structure of protein" ;
  rdfs:comment "The primary structure of a protein that is completely defined by the set of its amino acid residue parts and the linear order induced by the peptide bonds that hold them together"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:PATO_0001385 a rdfs:Class ;
  rdfs:label "aneuploid" ;
  rdfs:comment "A ploidy quality inhering in a bearer by virtue of the bearer's containing a non-integral multiple of the monoploid number, due to extra or missing chromosomes." ;
  rdfs:subClassOf obo:PATO_0001374 .

obo:OBI_1110086 a rdfs:Class ;
  rdfs:label "restricting MHC role"@en ;
  rdfs:comment "The role played by an MHC molecule by binding a material entity playing the role of epitope when that epitope/MHC molecule pair are recognized (bound) by a TCR molecule on the surface of a cell playing the role of effector cell."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000047 a rdfs:Class ;
  rdfs:label "obsolete processed material" ;
  rdfs:comment "Is a material entity that is created or changed during material processing."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001670 a rdfs:Class ;
  rdfs:label "RNA protection assay" ;
  rdfs:comment "An assay that determines the presence and estimates abundance of transcript species by first creating an homo or heteroduplex by adding a specific, complementary sequence to the sequence of interest and then exposing the mixture of ribonuclease, which will degrade only single stranded molecules. A detection step will reveal if the sample contained a sequence of interest."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0200102 a rdfs:Class ;
  rdfs:label "regression analysis method"@en ;
  rdfs:comment "Regression analysis is a descriptive statistics technique that examines the relation of a dependent variable (response variable) to specified independent variables (explanatory variables). Regression analysis can be used as a descriptive method of data analysis (such as curve fitting) without relying on any assumptions about underlying processes generating the data."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001072 a rdfs:Class ;
  rdfs:label "cryostat" ;
  rdfs:comment "A device consisting of a vessel, similar in construction to a vacuum flask, that is used to maintain cold cryogenic temperatures. FIX THIS DEFINITION"@en ;
  rdfs:subClassOf obo:OBI_0000967 , obo:OBI_0001034 .

obo:OBI_0003775 a rdfs:Class ;
  rdfs:label "dendrite-associated presynaptic puncta count assay" ;
  rdfs:comment "A regulation of synapse maturation assay that determines the number of synaptic puncta in the dendritic compartment of a neuron."@en ;
  rdfs:subClassOf obo:OBI_0003753 .

obo:OBI_0001381 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-23 production by T cells" ;
  rdfs:comment "A process of interleukin-23 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032627 , obo:OBI_0001193 .

obo:OBI_0002980 a rdfs:Class ;
  rdfs:label "reference protein sequence stop site" ;
  rdfs:comment "The position of the last amino acid in a reference protein sequence (sequence being used for comparison)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0003056 a rdfs:Class ;
  rdfs:label "proportion mapped reads" ;
  rdfs:comment "A sequence datum that is the specified output of a read mapping and is the ratio of the count of mapped reads to the total count of reads."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0002450 a rdfs:Class ;
  rdfs:label "hydroxyl-radical footprinting assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A hydroxyl-radical footprinting assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0002442 , obo:OBI_0002449 .

obo:OBI_0003306 a rdfs:Class ;
  rdfs:label "bulk Hi-C assay" ;
  rdfs:comment "A Hi-C assay in which the sample that is sequenced is derived from a collection of cells, such as a tissue sample or entire cell culture, and therefore provides results representative of the aggregate of sample cells."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:OBI_0600010 a rdfs:Class ;
  rdfs:label "material acquisition"@en ;
  rdfs:comment "An acquisition in which possession of a material entity is gained."@en ;
  rdfs:subClassOf obo:OBI_0600008 .

obo:OBI_0001667 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a purified-MHC:ligand complex approximated by IC50" ;
  rdfs:comment "A fluorescence detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation and provides IC50 values determined under assay conditions where the IC50 approximates a KD value."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001537 , obo:OBI_0001613 .

obo:OBI_0400040 a rdfs:Class ;
  rdfs:label "FACSAria" ;
  rdfs:comment "A FASCSAria is a flow_cytometer_sorter manufactured by Becton Dickinson. It features digital electronics, a solid state 488 nm blue laser, a solid state 407 nm violet laser, and a HeNe (633 nm) ion laser. The Aria has the filters and PMTs to collect side scatter and 9 fluorescent parameters. The Aria has a photodiode detector for forward scatter collector. The flow cell is Quartz cuvette. The FACSAria is a sorter used to collect and analyse cells using up to 11 parameters."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0001528 a rdfs:Class ;
  rdfs:label "material service" ;
  rdfs:comment "A service which has a material entity as specified input and/or specified output."@en ;
  rdfs:subClassOf obo:OBI_0001173 .

obo:OBI_0003121 a rdfs:Class ;
  rdfs:label "MHC:ligand complex" ;
  rdfs:comment "A complex of molecular entities which is the result of a MHC molecule binding with a ligand."@en ;
  rdfs:subClassOf obo:COB_0000080 .

obo:OBI_0002909 a rdfs:Class ;
  rdfs:label "arthropod resting outdoors on artificial support specimen collection by aspiration" ;
  rdfs:comment "An arthropod resting outdoors specimen collection by aspiration that occurs while the arthropod rests on a processed material such as a wall or furniture."@en ;
  rdfs:subClassOf obo:OBI_0002911 .

obo:OBI_0001825 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-C motif) ligand 19 production by T cells" ;
  rdfs:comment "A process of chemokine (C-C motif) ligand 19 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0097388 , obo:OBI_0001193 .

obo:OBI_0003023 a rdfs:Class ;
  rdfs:label "eosinophil assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of eosinophils"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:UBERON_0001359 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid" ;
  rdfs:comment "A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0003175 a rdfs:Class ;
  rdfs:label "fibrinogen concentration assay" ;
  rdfs:comment "A fibrinogen assay that measures the concentration of fibrinogen in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003010 .

obo:OBI_0302876 a rdfs:Class ;
  rdfs:label "dissolved material entity"@en ;
  rdfs:comment "A material entity that has been going through a process of being put into solution"@en ;
  rdfs:subClassOf obo:BFO_0000040 , obo:OBI_0000576 .

obo:OBI_0001741 a rdfs:Class ;
  rdfs:label "surface plasmon resonance assay measuring the on rate [kon] of a B cell epitope:antibody complex" ;
  rdfs:comment "A surface plasmon resonance binding assay that measures the on rate [kon] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000923 , obo:OBI_0001718 .

obo:OBI_0003817 a rdfs:Class ;
  rdfs:label "length measurement assay" ;
  rdfs:comment "An assay that measures the distance between two points."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:CHEBI_81568 a rdfs:Class ;
  rdfs:label "Luteinizing hormone" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002602 a rdfs:Class ;
  rdfs:label "multiplexed sequence data" ;
  rdfs:comment "Sequence data from a sequence library generated from at least two different sources, where each read in the sequence data includes base calls from a multiplex identifier sequence that can be used to trace the source of the read to its source."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:PATO_0001018 a rdfs:Class ;
  rdfs:label "physical quality" ;
  rdfs:comment "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBI_0001425 a rdfs:Class ;
  rdfs:label "protein binding site identification design" ;
  rdfs:comment "A study design that investigates protein binding sites on nucleic acids."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002388 a rdfs:Class ;
  rdfs:label "diagnosis of HIV" ;
  rdfs:comment "A diagnosis of infectious disease caused by the human immunodeficiency virus (1 or 2)."@en ;
  rdfs:subClassOf obo:OBI_0002385 .

obo:OBI_0003589 a rdfs:Class ;
  rdfs:label "serum anti-Epstein-Barr virus antibody level assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to Epstein-Barr virus (EBV) antigens in a serum sample."@en ;
  rdfs:subClassOf obo:OBI_0002145 , obo:OBI_0003040 .

obo:OBI_2100174 a rdfs:Class ;
  rdfs:label "non-vented blood gas arterial blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a non-vented blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0002642 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using survival."@en ;
  rdfs:subClassOf obo:OBI_0001696 , obo:OBI_0003479 .

obo:OBI_0003429 a rdfs:Class ;
  rdfs:label "creatine kinase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of creatine kinase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0000153 a rdfs:Class ;
  rdfs:label "cell co-culturing"@en ;
  rdfs:comment "A material combination in which cell cultures of two or more different types are are combined and allowed to culture as one."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_2100361 a rdfs:Class ;
  rdfs:label "venous blood T3 assay" ;
  rdfs:comment "An analyte assay that measures the abundance of T3 in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100046 .

obo:OBI_2100282 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0000688 a rdfs:Class ;
  rdfs:label "rodent care protocol" ;
  rdfs:comment "A rodent care protocol is an animal protocol in which the animals being taken care of are rodents."@en ;
  rdfs:subClassOf obo:OBI_0000715 .

obo:OBI_0001757 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-X-C motif) ligand 9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001459 .

obo:OBI_0000835 a rdfs:Class ;
  rdfs:label "manufacturer" ;
  rdfs:comment "A person or organization that has a manufacturer role."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0400106 a rdfs:Class ;
  rdfs:label "centrifuge" ;
  rdfs:comment "A device with a rapidly rotating container that applies centrifugal force to its contents"@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0000932 .

obo:OBI_0001162 a rdfs:Class ;
  rdfs:label "validation by reverse transcription PCR design" ;
  rdfs:comment "a study design in which checks the accuracy or the quality of the result of an assay  by comparing with reverse transcription PCR results"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003834 a rdfs:Class ;
  rdfs:label "neuron burst rate assay" ;
  rdfs:comment "An electrophysiology assay that measures the number of action potential bursts in neurons during a time period."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0002176 .

obo:OBI_0400045 a rdfs:Class ;
  rdfs:label "fluid pressure regulator" ;
  rdfs:comment "Part of the fluidic subsystem. The fluid pressure regulator maintains constant pressure within the sheath and or sample lines by filling the lines with enough gas to push the fluid at the desired rate. The gas is usually air, and less frequently nitrogen. In the sheath line, the gas is pushed into the sheath tank. In the sample line the gas is pushed into the collection tube. Fluid pressure regulators maintain great enough pressure to push sample fluid out of the tube and sheath fluid out of the sheath tank."@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0001034 .

obo:OBI_0003492 a rdfs:Class ;
  rdfs:label "SD Bioline Chikungunya IgM RDT kit" ;
  rdfs:comment "A device manufactured by Abbott for rapid detection of human IgM antibodies for Chikungunya virus in blood, using analytical chromatography."@en ;
  rdfs:subClassOf obo:OBI_0003369 .

obo:PATO_0001396 a rdfs:Class ;
  rdfs:label "cellular quality" ;
  rdfs:comment "A monadic quality of continuant that exists at the cellular level of organisation." ;
  rdfs:subClassOf obo:PATO_0070044 .

obo:OBI_0003549 a rdfs:Class ;
  rdfs:label "lower limit of detection" ;
  rdfs:comment "A value specification that specifies the smallest concentration/amount of a substance that can be detected in an analyte assay."@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_0000687 a rdfs:Class ;
  rdfs:label "nucleotide overhang cloning" ;
  rdfs:comment "Nucleotide overhang cloning is the process of inserting nucleic acid into a vector using nucleotide overhangs used to prevent self ligation"@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_0000976 a rdfs:Class ;
  rdfs:label "handedness categorical measurement datum" ;
  rdfs:comment "A datum used to record the answer to a self assessment of whether a person uses their left hand, right hand primarily or each hand equally"@en ;
  rdfs:subClassOf obo:OBI_0000938 .

obo:OBI_0000999 a rdf:Property ;
  rdfs:label "has category label" ;
  rdfs:comment "A relation between a categorical measurement data item and the categorical label that indicates the value of that data item on the categorical scale."@en ;
  rdfs:domain obo:OBI_0000938 ;
  rdfs:range obo:OBI_0000963 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:OBI_0002991 a rdfs:Class ;
  rdfs:label "B cell receptor repertoire sequencing assay" ;
  rdfs:comment "A sequencing assay that determines the sequence of a DNA or RNA molecules that encode the repertoire of B cell receptors within an input sample."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OGMS_0000073 a rdfs:Class ;
  rdfs:label "diagnosis" ;
  rdfs:comment "The representation of a conclusion of a diagnostic process."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:IAO_8000018 a rdfs:Class ;
  rdfs:label "obo basic subset ontology module"@en ;
  rdfs:comment """A subset ontology that is designed for basic applications to continue to make certain simplifying assumptions; many of these simplifying assumptions were based on the initial version of the Gene Ontology, and have become enshrined in many popular and useful tools such as term enrichment tools.

Examples of such assumptions include: traversing the ontology graph ignoring relationship types using a naive algorithm will not lead to cycles (i.e. the ontology is a DAG); every referenced term is declared in the ontology (i.e. there are no dangling clauses).

An ontology is OBO Basic if and only if it has the following characteristics:
DAG
Unidirectional
No Dangling Clauses
Fully Asserted
Fully Labeled
No equivalence axioms
Singly labeled edges
No qualifier lists
No disjointness axioms
No owl-axioms header
No imports"""@en ;
  rdfs:seeAlso <http://owlcollab.github.io/oboformat/doc/obo-syntax.html#6.2> ;
  rdfs:subClassOf obo:IAO_8000017 .

obo:OBI_0003045 a rdfs:Class ;
  rdfs:label "parasite detection by PCR assay" ;
  rdfs:comment "A parasite detection assay that uses PCR."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0003038 .

obo:OBI_0600046 a rdfs:Class ;
  rdfs:label "preparative chromatography"@en ;
  rdfs:comment "the use of a biomaterial's preferential affinity for either the mobile phase or the stationary phase to separate it from other materials of differing affinity"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:UBERON_0000323 a rdfs:Class ;
  rdfs:label "late embryo" ;
  rdfs:comment "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0302895 a rdfs:Class ;
  rdfs:label "electrocution"@en ;
  rdfs:comment "electrocution is process by which electric current is applied to a material with quality alive and result the termination of life process."@en ;
  rdfs:subClassOf obo:OBI_0000919 .

obo:OBA_2060181 a rdfs:Class ;
  rdfs:label "upper limb coordination efficacy" ;
  rdfs:comment "The process efficacy of a upper limb coordination." ;
  rdfs:subClassOf obo:OBA_2060180 .

obo:OBI_0003722 a rdfs:Class ;
  rdfs:label "natural killer cell count assay" ;
  rdfs:comment "A cytometry assay to determine the number of natural killer cells in a specimen"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0001944 a rdfs:Class ;
  rdfs:label "sequence annotation"@en ;
  rdfs:comment "A planned process that identifies and reports sequence features (e.g. protein coding regions) in sequence data."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002168 a rdfs:Class ;
  rdfs:label "subcellular protein immunohistochemistry assay" ;
  rdfs:comment "An immunohistochemistry assay that uses antibodies to display the specific subcellular location of proteins."@en ;
  rdfs:subClassOf obo:OBI_0001986 .

obo:OBI_0003582 a rdfs:Class ;
  rdfs:label "cell proliferation assay using carboxyfluorescein succinimidyl ester staining" ;
  rdfs:comment "A cell proliferation assay that uses carboxyfluorescein succinimidyl ester staining to detect cell division."@en ;
  rdfs:subClassOf obo:OBI_0000891 , obo:OBI_0002106 .

obo:OBI_0001270 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects transforming growth factor-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001264 .

obo:OBI_0001450 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-4 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:PR_000025471 a rdfs:Class ;
  rdfs:label "nuclease S1" ;
  rdfs:comment "A protein that is a translation product of the Aspergillus oryzae RIB40 nucS gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0000883 a rdfs:Class ;
  rdfs:label "in vivo cell killing assay" ;
  rdfs:comment "A cell killing assay that measures if and how many target cells are killed within an organism."@en ;
  rdfs:subClassOf obo:OBI_0000882 .

obo:GO_0008283 a rdfs:Class ;
  rdfs:label "cell population proliferation" ;
  rdfs:comment "The multiplication or reproduction of cells, resulting in the expansion of a cell population." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0002808 a rdfs:Class ;
  rdfs:label "reusable footwear cover" ;
  rdfs:comment "A footwear cover which is designed for repeated use."@en ;
  rdfs:subClassOf obo:OBI_0002806 .

obo:OBI_2100015 a rdfs:Class ;
  rdfs:label "phosphate ion assay" ;
  rdfs:comment "An analyte assay that measures the abundance of phosphate ion"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001151 a rdfs:Class ;
  rdfs:label "genetically modified material"@en ;
  rdfs:comment "a material entity, organism or cell,  that is the output of a genetic transformation process."@en ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_1000042 a rdfs:Class ;
  rdfs:label "peptide construct"@en ;
  rdfs:comment "a material entity synthesized to contain a number of peptides conjugated together in a non-linear fashion"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003277 a rdfs:Class ;
  rdfs:label "virus in nasopharyngeal or oropharyngeal swab datum" ;
  rdfs:comment "A nasopharyngeal or oropharyngeal swab microbiology datum that is about a virus."@en ;
  rdfs:subClassOf obo:OBI_0003257 .

obo:OBI_0000023 a rdfs:Class ;
  rdfs:label "classified data set"@en ;
  rdfs:comment "A data set that is produced as the output of a class prediction data transformation and consists of a data set with assigned class labels."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_1110013 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001445 , obo:OBI_0600031 .

obo:GO_0008228 a rdfs:Class ;
  rdfs:label "opsonization" ;
  rdfs:comment "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." ;
  rdfs:subClassOf obo:GO_0006909 .

obo:OBI_0001114 a rdfs:Class ;
  rdfs:label "nucleic acid extraction/purification instrument" ;
  rdfs:comment "A device that is used to isolate and collect nucleic acids (DNA or RNA) for subsequent molecular analysis."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0400015 a rdfs:Class ;
  rdfs:label "BioSorter2000" ;
  rdfs:comment "A BioSorter2000 is a sorter manufactured by Union Biometrica. It includes analog electronics, 488/514 nm multi-line Argon-ion laser for fluorescence and a light stabilized 670 nm forward scatter laser for extinction and time-of-flight. It has filters and PMTs for 3 fluorescent parameters and photodiodes for scatter, time of flight, and extinction. The flow cell is quartz cuvette. The BioSorterTM 2000 is an instrument for analyzing and sorting objects from 500 microns to 1.5 millimeters in diameter."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:UBERON_0011011 a rdfs:Class ;
  rdfs:label "brachioradialis" ;
  rdfs:comment "Brachioradialis is a muscle of the forearm that acts to flex the forearm at the elbow. It is also capable of both pronation and supination, depending on the position of the forearm. It is attached to the distal styloid process of the radius by way of the brachioradialis tendon, and to the lateral supracondylar ridge of the humerus." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0002377 a rdfs:Class ;
  rdfs:label "mother clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female parent."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0001735 a rdfs:Class ;
  rdfs:label "ELISA measuring the association constant [KA] of a B cell epitope:antibody complex" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that measures the association constant [KA] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001719 .

obo:SO_0000988 a rdfs:Class ;
  rdfs:label "circular" ;
  rdfs:comment "A quality of a nucleotide polymer that has no terminal nucleotide residues." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBI_0003631 a rdfs:Class ;
  rdfs:label "antibody purification of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003627 .

obo:CHEBI_42191 a rdfs:Class ;
  rdfs:label "EDTA(4-)" ;
  rdfs:comment "A tetracarboxylic acid anion formed by deprotonation of all four carboxy groups in ethylenediaminetetraacetic acid (EDTA)." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002613 a rdfs:Class ;
  rdfs:label "environmental swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of an environmenal material."@en ;
  rdfs:subClassOf obo:OBI_0002599 , obo:OBI_0100051 .

obo:OBI_0000016 a rdfs:Class ;
  rdfs:label "regulation-assigned role"@en ;
  rdfs:comment "Regulation-assigned role is a regulatory role defined by legislation or governmental orders"@en ;
  rdfs:subClassOf obo:OBI_0000017 .

obo:OBI_0002562 a rdfs:Class ;
  rdfs:label "country of residence inclusion criteria"@en ;
  rdfs:comment "An inclusion criterion that defines and states one or more countries of residence which, if met, makes a human being suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0003524 a rdfs:Class ;
  rdfs:label "tandem stance assessment" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet in tandem placement."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0100014 a rdfs:Class ;
  rdfs:label "chimera"@en ;
  rdfs:comment "An organism which contains cells or tissues with a different genotype"@en ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0302884 a rdfs:Class ;
  rdfs:label "extraction"@en ;
  rdfs:comment "A material separation in which a desired component of an input material is separated from the remainder"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0000695 a rdfs:Class ;
  rdfs:label "chain termination sequencing assay" ;
  rdfs:comment "A DNA sequencing assay which rely on the use of dideoxynucleotides used in 4 distinct sequencing reaction on the same DNA sample. The dideoxynucleotides, once incorporated in the complementary DNA strand being synthesized by the DNA polymerase prevent any further chain elongation. The newly generated sequences are resolved on a polyacrylamide gel using electrophoresis and labels (either fluorochrome or radioactivity) are used to determine the nucleotide present at a given position"@en ;
  rdfs:subClassOf obo:OBI_0000734 .

obo:OBI_0001723 a rdfs:Class ;
  rdfs:label "assay measuring the off rate [koff] of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope binding constant determination assay that measures the off rate."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001709 .

obo:OBI_0002158 a rdfs:Class ;
  rdfs:label "HIV-1 nucleic acid testing" ;
  rdfs:comment "An analyte assay that is meant to detect human immunodeficiency virus (HIV-1) nucleic acids."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000858 a rdfs:Class ;
  rdfs:label "record of unknown sex" ;
  rdfs:comment "a record indicating that the biological sex of an organism is not known."@en ;
  rdfs:subClassOf obo:OBI_0000852 .

obo:OBI_2100230 a rdfs:Class ;
  rdfs:label "chem11 venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0000323 a rdfs:Class ;
  rdfs:label "obsolete_peritoneum" ;
  rdfs:comment "is the serous membrane that forms the lining of the abdominal cavity"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001822 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-23 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-23 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001363 , obo:OBI_0600031 .

obo:OBI_0001363 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-23 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-23 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0000739 a rdfs:Class ;
  rdfs:label "Student's t-test" ;
  rdfs:comment "Studen't t-test is a data transformation with the objective of a statistical hypothesis test in which the test statistic has a Student's t distribution if the null hypothesis is true. It is applied when the population is assumed to be normally distributed but the sample sizes are small enough that the statistic on which inference is based is not normally distributed because it relies on an uncertain estimate of standard deviation rather than on a precisely known value."@en ;
  rdfs:subClassOf obo:OBI_0000673 .

obo:OBI_1110107 a rdfs:Class ;
  rdfs:label "cultured effector T cell population" ;
  rdfs:comment "A cell culture including cells that have an effector T cell function"@en ;
  rdfs:subClassOf obo:OBI_0001875 .

obo:OBI_0600025 a rdfs:Class ;
  rdfs:label "substance detection assay" ;
  rdfs:comment "An assay that detects a specified substance"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002748 a rdfs:Class ;
  rdfs:label "passage history record"@en ;
  rdfs:comment "A data item that is about the sequence of environmental systems in each of which is grown an organism in a passage process."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0001764 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects chemokine (C-C motif) ligand 4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001345 , obo:OBI_0003115 .

obo:OBI_0001516 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring half maximal effective concentration [EC50] to determine direct binding of a cell-lysate-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures half maximal effective concentration (EC50) to detect the direct binding of a cell-lysate-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001991 .

obo:OBI_0000117 a rdfs:Class ;
  rdfs:label "Bernoulli trial" ;
  rdfs:comment "An assay where the output data is a datum with one of two values denoting success and failure."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003367 a rdfs:Class ;
  rdfs:label "diagnosis of an organism"@en ;
  rdfs:comment "A conclusion based on data about that an organism has a disease, disorder, or syndrome of a certain type, or none of these."@en ;
  rdfs:subClassOf obo:OBI_0001909 .

obo:OBI_0000124 a rdf:Property ;
  rdfs:label "is_supported_by_data" ;
  rdfs:comment "The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process"@en ;
  rdfs:domain obo:OBI_0001909 ;
  rdfs:range obo:IAO_0000027 .

obo:OBI_0400157 a rdfs:Class ;
  rdfs:label "oil bath" ;
  rdfs:comment "An oil bath is a temperature control bath in which oil acts as contact medium for the temperature transfer (from heating or cooling elements to the sample)."@en ;
  rdfs:subClassOf obo:OBI_0400120 .

obo:OBI_0002073 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that uses a epitope protection experiment."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0001484 .

obo:BFO_0000029 a rdfs:Class ;
  rdfs:label "site"@en ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:OBI_0003852 a rdfs:Class ;
  rdfs:label "Hoechst dye assay" ;
  rdfs:comment "A fluorescence imaging-based cell morphology assay that uses Hoechst dye 33342"@en ;
  rdfs:subClassOf obo:OBI_0002951 .

obo:OBI_0003083 a rdfs:Class ;
  rdfs:label "specimen collection time post disease onset" ;
  rdfs:comment "A specimen collection time measurement datum that is the measure of a time when specimens are collected after the onset of disease in a host."@en ;
  rdfs:subClassOf obo:OBI_0001619 .

obo:OBI_0002115 a rdfs:Class ;
  rdfs:label "cytometry time of flight assay" ;
  rdfs:comment "A cytometry assay in which the presence of molecules of interest on or in cells is indicated by binding of antibodies labeled with rare earth element tags which are detected by time-of-flight mass spectrometry."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:IAO_0000001 a rdfs:Class ;
  rdfs:label "conditional specification"@en ;
  rdfs:comment "A directive information entity that specifies what should happen if the trigger condition is fulfilled."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0002084 a rdfs:Class ;
  rdfs:label "transcription cofactor activity region identification by ChIP-Seq assay" ;
  rdfs:comment "A ChIP-seq assay that identifies regions of chromatin bound to a chromatin modifying protein, e.g. a histone acetyltransferase."@en ;
  rdfs:subClassOf obo:OBI_0000716 .

obo:OBI_0302898 a rdfs:Class ;
  rdfs:label "intentional overdosing"@en ;
  rdfs:comment "intentional overdosing is a process by which an excess dose of a chemical compound is given with the intent of causing death"@en ;
  rdfs:subClassOf obo:OBI_0000919 .

obo:OBI_0001949 a rdfs:Class ;
  rdfs:label "sequence annotation reporting role"@en ;
  rdfs:comment "A reporting party role that is realized by a person or organization who reports the feature annotation results from the analysis of a macromolecular sequence."@en ;
  rdfs:subClassOf obo:OBI_0000068 .

obo:OBI_0002703 a rdfs:Class ;
  rdfs:label "insecticide resistance by detecting carboxylic ester hydrolase activity assay" ;
  rdfs:comment "An insecticide resistance by detecting enzyme activity assay that measures activity of carboxylic ester hydrolase using p-nitrophenyl acetate as a substrate."@en ;
  rdfs:subClassOf obo:OBI_0002697 .

obo:OBI_0000398 a rdfs:Class ;
  rdfs:label "image creation device" ;
  rdfs:comment "An image creation device is a device which captures a digitized image of an object"@en ;
  rdfs:subClassOf obo:COB_0001300 , obo:OBI_0000832 .

obo:OBI_0002072 a rdfs:Class ;
  rdfs:label "assay measuring qualitative binding of a MHC:ligand complex" ;
  rdfs:comment "An assay that detects the binding of a MHC molecule with a ligand, and produces a qualitative measurement of the binding as an output."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110126 .

obo:OBI_2100192 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0002794 a rdfs:Class ;
  rdfs:label "reusable patient gown" ;
  rdfs:comment "A patient gown intended to be reused after being laundered."@en ;
  rdfs:subClassOf obo:OBI_0002792 .

obo:OBI_0003564 a rdfs:Class ;
  rdfs:label "intraepidermal administration" ;
  rdfs:comment "An administration of a substance into the epidermis of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0001478 a rdfs:Class ;
  rdfs:label "mass spectrometry assay measuring MHC ligand processing and presentation" ;
  rdfs:comment "A MHC ligand processing and presentation assay that uses a mass spectrometry assay to identify eluted ligands"@en ;
  rdfs:subClassOf obo:OBI_1110125 .

obo:OBI_0003074 a rdfs:Class ;
  rdfs:label "common name of organism" ;
  rdfs:comment "A textual entity refers to a taxon or organism that is based on the normal language of everyday life; this kind of name is often contrasted with the scientific name for the same organism, which is Latinized."@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:OBI_0003153 a rdfs:Class ;
  rdfs:label "creatinine concentration assay" ;
  rdfs:comment "A creatinine assay that measures the concentration of creatinine in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100003 .

obo:OBI_0003350 a rdfs:Class ;
  rdfs:label "T2 weighted FSE  magnetic resonance image data set" ;
  rdfs:comment "T2 weighted image collected using a fast/turbo spin echo sequence."@en ;
  rdfs:subClassOf obo:OBI_0003348 .

obo:GO_0032630 a rdfs:Class ;
  rdfs:label "interleukin-26 production" ;
  rdfs:comment "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0001509 a rdfs:Class ;
  rdfs:label "Edman degradation assay measuring MHC ligand processing and presentation" ;
  rdfs:comment "A MHC ligand processing and presentation assay that uses Edman degradation to identify the eluted ligands"@en ;
  rdfs:subClassOf obo:OBI_1110125 .

obo:GO_0034343 a rdfs:Class ;
  rdfs:label "type III interferon production" ;
  rdfs:comment "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:PATO_0000957 a rdfs:Class ;
  rdfs:label "opacity" ;
  rdfs:comment "An optical quality which obtains by virtue of the ability of the bearer to absorb visible light." ;
  rdfs:subClassOf obo:PATO_0001300 .

obo:OBI_0001652 a rdfs:Class ;
  rdfs:label "immuno staining assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An immuno staining assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001632 , obo:OBI_0001703 .

obo:OBI_1110035 a rdfs:Class ;
  rdfs:label "Jurkat cell line"@en ;
  rdfs:comment "A cell line derived from human T cells."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0001876 a rdfs:Class ;
  rdfs:label "cell culture" ;
  rdfs:comment "A material entity comprised of cultured cells and the media in which they are being propagated or stored."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:CHMO_0000701 a rdfs:Class ;
  rdfs:label "liquid chromatography-tandem mass spectrometry" ;
  rdfs:comment "A method where a sample mixture is first separated by liquid chromatography before being ionised and characterised by mass-to-charge ratio and relative abundance using two mass spectrometers in series."@en ;
  rdfs:subClassOf obo:OBI_0003097 , obo:OBI_0003540 .

obo:OBI_0000723 a rdfs:Class ;
  rdfs:label "DNA sequencing by ligation assay" ;
  rdfs:comment "A DNA sequencing assay that performs chain extension during the sequencing reaction step using DNA ligase"@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0000861 a rdfs:Class ;
  rdfs:label "Likelihood-ratio test" ;
  rdfs:comment "Likelihood-ratio is a data transformation which tests whether there is evidence of the need to move from a simple model to a more complicated one (where the simple model is nested within the complicated one); tests of the goodness-of-fit between two models."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001527 a rdfs:Class ;
  rdfs:label "support service" ;
  rdfs:comment "A service  in which the service provider assists the consumer in activities directly or indirectly associated with the production and analysis of experimental research data."@en ;
  rdfs:subClassOf obo:OBI_0001173 .

obo:PR_000003015 a rdfs:Class ;
  rdfs:label "prostate-specific antigen" ;
  rdfs:comment "A trypsin that is a translation product of the human KLK3 gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:GO_0003964 a rdfs:Class ;
  rdfs:label "RNA-directed DNA polymerase activity" ;
  rdfs:comment "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:GO_0002534 a rdfs:Class ;
  rdfs:label "cytokine production involved in inflammatory response" ;
  rdfs:comment "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0002913 a rdfs:Class ;
  rdfs:label "arthropod specimen collection process" ;
  rdfs:comment "A specimen collection process that has the objective of collecting arthropods as specimens."@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:OBI_0400053 a rdfs:Class ;
  rdfs:label "helium neon ion laser" ;
  rdfs:comment "A helium-neon laser (HeNe) is an ion laser that uses helium and neon gas-ions as lasing medium. HeNe lasers emit at 543 nm and 633 nm most commonly and can also be used at 543, 594, and 611 nm."@en ;
  rdfs:subClassOf obo:OBI_0400060 .

obo:OBI_2100254 a rdfs:Class ;
  rdfs:label "POC chem8 arterial blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in arterial blood as part of a POC chem8 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:OBI_0003300 a rdfs:Class ;
  rdfs:label "nucleolus-associated domain sequencing assay" ;
  rdfs:comment "A DNA sequencing assay in which nucleoli are isolated and the DNA associated with them is sequenced to identify nucleoli-associating domains."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0002699 a rdfs:Class ;
  rdfs:label "insecticide resistance by detecting alpha esterase activity assay" ;
  rdfs:comment "An insecticide resistance by detecting enzyme activity assay that measures activity of alpha esterase."@en ;
  rdfs:subClassOf obo:OBI_0002697 .

obo:OBI_0003131 a rdfs:Class ;
  rdfs:label "directed mutagenesis" ;
  rdfs:comment "An induced mutation in which a specific gene(s) or part of a gene(s) is altered."@en ;
  rdfs:subClassOf obo:OBI_0001154 .

obo:OBI_2000013 a rdfs:Class ;
  rdfs:label "arterial blood specimen" ;
  rdfs:comment "A specimen that is derived from some arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0001179 a rdfs:Class ;
  rdfs:label "epitope protection from infectious challenge experiment" ;
  rdfs:comment "An epitope protection experiment in which the ability of the epitope to protect the host from an infection is assessed."@en ;
  rdfs:subClassOf obo:OBI_0001184 .

obo:OBI_0003700 a rdfs:Class ;
  rdfs:label "phase I clinical trial"@en ;
  rdfs:comment "A clinical trial that produces information about the safety of a drug and the adverse events associated with that drug, and which is typically conducted with healthy participants."@en ;
  rdfs:subClassOf obo:OBI_0003699 .

obo:OBI_2100322 a rdfs:Class ;
  rdfs:label "ionized venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood as part of a ionized order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0002587 a rdfs:Class ;
  rdfs:label "machine learning" ;
  rdfs:comment "A planned process with the objective to give a computer the ability to use patterns in data to progressively improve its performance on a specific task, achieved by using statistical techniques instead of explicitly programming the ability."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003664 a rdfs:Class ;
  rdfs:label "Illumina NovaSeq X Plus" ;
  rdfs:comment "A DNA sequencer with three flow cell types manufactured by Illumina. It features a dual-flow cell configuration, allowing to reach an output of up to 16 Tb (52-104 billion reads per run). The sequencer utilizes XLEAP-SBS chemistry, an advanced version of Illumina's sequencing by synthesis (SBS) technology, which enables faster and more accurate sequencing."@en ;
  rdfs:subClassOf obo:OBI_0003685 .

obo:OBI_0000387 a rdfs:Class ;
  rdfs:label "cool function"@en ;
  rdfs:comment "A cool function is a function to decrease the internal kinetic energy of a material below the initial kinetic energy of that type of material."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0002941 a rdfs:Class ;
  rdfs:label "resting bucket" ;
  rdfs:comment "An arthropod trap that consists of a bucket, which is lined with fabric and placed on its side, and a wet cloth inside the bucket. The placement of the box and modifications to it are done in such a way that it becomes attractive to an arthropod as a place to rest during a period of inactivity (not actively seeking a host)."@en ;
  rdfs:subClassOf obo:OBI_0002939 .

obo:OBI_2100095 a rdfs:Class ;
  rdfs:label "venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0600020 a rdfs:Class ;
  rdfs:label "histological assay" ;
  rdfs:comment "An assay that uses visual examination of cells or tissue (or images of them) to make an assessment regarding a quality of the cells or tissue. This assay can include steps of staining, imaging, and judgement."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0003997 a rdfs:Class ;
  rdfs:label "acyl-CoA oxidase activity" ;
  rdfs:comment "Catalysis of the reaction: a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0000640 a rdfs:Class ;
  rdfs:label "indirect detection probe" ;
  rdfs:comment "An NMR probe designed to allow the indirect detection of acquisition nuclei."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_2100355 a rdfs:Class ;
  rdfs:label "venous blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_2100135 a rdfs:Class ;
  rdfs:label "venous blood transferrin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of transferrin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003013 , obo:OBI_0003040 .

obo:OBI_1110129 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific cytokine production by T cells" ;
  rdfs:comment "A T cell epitope assay that detects cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002055 .

obo:OBI_0200187 a rdfs:Class ;
  rdfs:label "sequence analysis data transformation"@en ;
  rdfs:comment "A sequence analysis data transformation is a data transformation that has objective sequence analysis and has the aim of analysing ordered biological data for sequential patterns."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:GO_0032614 a rdfs:Class ;
  rdfs:label "interleukin-11 production" ;
  rdfs:comment "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000576 a rdfs:Class ;
  rdfs:label "scattered molecular aggregate"@en ;
  rdfs:comment "a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0000010 a rdfs:Class ;
  rdfs:label "peripheral nervous system" ;
  rdfs:comment "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001103 a rdfs:Class ;
  rdfs:label "rocker" ;
  rdfs:comment "A device that provides three-dimensional motion for biomedical applications (e.g., gel trays)."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:GO_0044423 a rdfs:Class ;
  rdfs:label "virion component" ;
  rdfs:comment "Any constituent part of a virion, a complete fully infectious extracellular virus particle." ;
  rdfs:subClassOf obo:GO_0005575 .

obo:OBI_0000872 a rdfs:Class ;
  rdfs:label "serum neutralization of viral infectivity assay" ;
  rdfs:comment "An analyte assay that measures virus-neutralizing abilities of different sera. Different dilutions of serum are mixed with virus and used to infect cells. At the lower dilutions, antibodies will block infection, but at higher dilutions, there will be too few antibodies to have an effect.The neutralization titer is expressed as the reciprocal of the highest dilution at which virus infection is blocked."@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:GO_0010573 a rdfs:Class ;
  rdfs:label "vascular endothelial growth factor production" ;
  rdfs:comment "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000968 a rdfs:Class ;
  rdfs:label "obsolete device" ;
  rdfs:comment "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100293 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_2100167 a rdfs:Class ;
  rdfs:label "ionized venous blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in venous blood as part of a ionized order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0003530 a rdfs:Class ;
  rdfs:label "limb coordination assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to coordinate limb movement."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0002174 a rdfs:Class ;
  rdfs:label "immunocytochemistry" ;
  rdfs:comment "An immuno staining assay in which samples of intact cells are examined that have had most, if not all, of their surrounding extracellular matrix removed"@en ;
  rdfs:subClassOf obo:OBI_0001632 , obo:OBI_0001977 .

obo:COB_0000032 a rdfs:Class ;
  rdfs:label "obsolete geographical location" .

obo:CHEBI_51760 a rdfs:Class ;
  rdfs:label "Alexa Fluor 546" ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:OBI_0002030 a rdfs:Class ;
  rdfs:label "genotyping by tiling array assay" ;
  rdfs:comment "A genotyping by array assay that uses tiling array technology."@en ;
  rdfs:subClassOf obo:OBI_0001274 .

obo:OBI_1110172 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001414 .

obo:OBI_0002083 a rdfs:Class ;
  rdfs:label "enhancer activity detection by reporter gene assay" ;
  rdfs:comment "A reporter gene assay that detects expression of a reporter gene that was inserted under the control of an enhancer of interest."@en ;
  rdfs:subClassOf obo:OBI_0002082 .

obo:OBI_0302743 a rdfs:Class ;
  rdfs:label "obsolete_liver" ;
  rdfs:comment "liver is an anatomical entity which constituent are mainly hepatocytes, which has a function of detoxification, hematopoietic center, glucose and fat metabolism management. liver is only found in animals , all Vertebrates and some families of invertebrates"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:UBERON_0001159 a rdfs:Class ;
  rdfs:label "sigmoid colon" ;
  rdfs:comment "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001415 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-9 production by T cells" ;
  rdfs:comment "A process of interleukin-9 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032638 , obo:OBI_0001193 .

obo:OBI_0003567 a rdfs:Class ;
  rdfs:label "urethral administration" ;
  rdfs:comment "An administration of a substance into the urethra of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:IAO_8000010 a rdfs:Class ;
  rdfs:label "exclusion subset ontology module"@en ;
  rdfs:comment "A subset of an ontology that is intended to be excluded for some purpose. For example, a blacklist of classes."@en ;
  rdfs:subClassOf obo:IAO_8000006 .

obo:GO_0070288 a rdfs:Class ;
  rdfs:label "ferritin complex" ;
  rdfs:comment "A protein complex that binds iron and acts as a major iron storage system. There are three major subclasses of ferritins: the classical ferritins (Ftn), the heme-containing bacterioferritins (Bfr) and the DNA-binding proteins from starved cells (Dps). Ftn and Bfr are made of 24 subunits, whereas Dps are smaller with 12 subunits. Ftn is found in most kindoms, while Bfr and Dps are restricted to prokaryotes." ;
  rdfs:subClassOf obo:GO_0032991 .

obo:OBI_0001837 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001280 .

obo:OBI_0003570 a rdfs:Class ;
  rdfs:label "intracarotid administration" ;
  rdfs:comment "An intra-arterial administration in which the substance is administered into the carotid artery."@en ;
  rdfs:subClassOf obo:OBI_0003561 .

obo:CHEBI_27226 a rdfs:Class ;
  rdfs:label "uric acid" ;
  rdfs:comment "An oxopurine that is the final oxidation product of purine metabolism." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0600031 a rdfs:Class ;
  rdfs:label "enzyme-linked immunospot assay" ;
  rdfs:comment "A cytometry assay in which cells are cultured on a surface coated with a capture antibody binding a secretory material of interest which subsequently gets stained resulting in a spot for each cell producing the secretory material of interest."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003587 .

obo:OBI_0002142 a rdfs:Class ;
  rdfs:label "Nanostring nCounter miRNA expression assay" ;
  rdfs:comment "A microRNA profiling assay using digital molecular barcoding technology to quantify target microRNA molecules without the need for amplification."@en ;
  rdfs:subClassOf obo:OBI_0001926 .

obo:OBI_0002523 a rdfs:Class ;
  rdfs:label "breast specimen" ;
  rdfs:comment "A specimen that is derived from breast."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0500014 a rdfs:Class ;
  rdfs:label "factorial design" ;
  rdfs:comment "factorial design is_a study design which is used to evaluate two or more factors simultaneously. The treatments are combinations of levels of the factors. The advantages of factorial designs over one-factor-at-a-time experiments is that they are more efficient and they allow interactions to be detected. In statistics, a factorial design experiment is an experiment whose design consists of two or more factors, each with discrete possible values or levels, and whose experimental units take on all possible combinations of these levels across all such factors. Such an experiment allows studying the effect of each factor on the response variable, as well as the effects of interactions between factors on the response variable."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:GO_0032607 a rdfs:Class ;
  rdfs:label "interferon-alpha production" ;
  rdfs:comment "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032606 .

obo:OBI_0002952 a rdfs:Class ;
  rdfs:label "fluorescence imaging multiplex cytological profiling" ;
  rdfs:comment "A type of cytometry assay in which fluorescent dyes are used to stain seven major cellular components followed by automatic image capture and analysis which extracts shape, texture, and intensity parameters."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000734 a rdfs:Class ;
  rdfs:label "DNA sequencing by synthesis assay" ;
  rdfs:comment "A DNA sequencing assay that relies on DNA polymerase activity to perform chain extension during the sequencing reaction step."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:CHEBI_33376 a rdfs:Class ;
  rdfs:label "terbium atom" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0200146 a rdfs:Class ;
  rdfs:label "subgraph modularity calculation"@en ;
  rdfs:comment "A network subgraph quality calculation in which an input data set of subgraph in-degree and out-degree qualities is used to calculate the ratio of indegree to outdegree as a measure of modularity."@en ;
  rdfs:subClassOf obo:OBI_0200137 .

obo:OBI_0003632 a rdfs:Class ;
  rdfs:label "antibody purification of H2-Dd protein complex and/or H2-Kd protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex and/or H2-Kd protein complex while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003627 .

obo:OBI_0002078 a rdfs:Class ;
  rdfs:label "specimen set collection process"@en ;
  rdfs:comment "A specimen collection process that generates multiple specimens from one source (e.g. one organism) during a time period which for the purpose of the study can be considered to be taken at the same sampling time."@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:GO_0004448 a rdfs:Class ;
  rdfs:label "isocitrate dehydrogenase [NAD(P)+] activity" ;
  rdfs:comment "Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0000919 a rdfs:Class ;
  rdfs:label "animal euthanization" ;
  rdfs:comment "A process in which is the end of life of animal is brought about in accordance with local regulations on treatment of animal subjects and using a method which causes minimal pain and distress to the animal subject"@en ;
  rdfs:subClassOf obo:OBI_0600006 .

obo:OBI_0001144 a rdfs:Class ;
  rdfs:label "binding constant"@en ;
  rdfs:comment "A quantitative binding datum that is expressed as a scalar number and a unit, which can be utilized in equations that model the binding process independent of the specific assay performed."@en ;
  rdfs:subClassOf obo:OBI_0003142 .

obo:OBI_0003034 a rdfs:Class ;
  rdfs:label "cleavage under targets and tagmentation" ;
  rdfs:comment "A type of DNA sequencing assay employing in situ chromatin profiling in which a chromatin protein is bound in situ by a specific antibody, which then tethers to a protein A-Tn5 hyperactive transposase fusion protein (pA-Tn5) loaded with sequence adapters. Activation of pA-Tn5 results in factor-targeted tagmentation, generating fragments ready for PCR enrichment and DNA sequencing."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0200028 a rdfs:Class ;
  rdfs:label "quantile transformation"@en ;
  rdfs:comment "A quantile transformation is a data transformation that takes as input a collection of data sets, where each can be thought as an n-dimensional (real) vector, and which transforms each data set so that the resulting output data sets have equal quantiles."@en ;
  rdfs:subClassOf obo:OBI_0200169 , obo:OBI_0200181 .

obo:OBI_0000364 a rdfs:Class ;
  rdfs:label "ion detector" ;
  rdfs:comment "An ion detector is a device that measures and records the charge induced or current produced when an ion passes by or hits a surface.  Example: In a scanning instrument the signal produced in the detector during the course of the scan versus where the instrument is in the scan (at what m/Q) will produce a mass spectrum, a record of ions as a function of m/Q."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0200150 a rdfs:Class ;
  rdfs:label "MA transformation" ;
  rdfs:comment "An MA transformation is a data transformation which takes as input a collection of data points (g_1, r_1), (g_2, r_2), ..., (g_n, r_n)  with the r_i and g_i positive real numbers, and whose output is the collection of data points (A_1, M_1), (A_2, M_2), ..., (A_n, M_n) where, for each i, A_i=(log(g_i)+log(r_i))/2 and M_i=log(r_i)-log(g_i). Here log denotes a logarithmic transformation."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0000568 a rdfs:Class ;
  rdfs:label "piston-seal" ;
  rdfs:comment "The seal made by a piston in a diaphragm pump. The unique property of the reciprocating diaphragm pump is that the actuating piston does not come into direct contact with the mobile phase and thus, the demands on the piston-cylinder seal are not so great. The diaphragm has a relatively high surface area and thus, the movement of the diaphragm is relatively small and consequently the pump can be operated at a fairly high frequency. High frequency pumping results in a very significant reduction in pulse amplitude and, in addition, high frequency pulses are more readily damped by the column system. Nevertheless, it must be emphasized that diaphragm pumps are not pulseless."@en ;
  rdfs:subClassOf obo:OBI_0000601 .

obo:OBI_0002479 a rdfs:Class ;
  rdfs:label "sequence read length measurement datum"@en ;
  rdfs:comment "A measurement datum that is the result of the measurement of the number of bases in a DNA or RNA sequence."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_2100040 a rdfs:Class ;
  rdfs:label "methemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of methemoglobin"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001397 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific granulocyte colony stimulating factor production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects granulocyte colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001600 , obo:OBI_0003115 .

obo:OBI_0200001 a rdfs:Class ;
  rdfs:label "geometric mean calculation"@en ;
  rdfs:comment "A data transformation in which the mean is calculated by taking the nth root of the product of all of the observations in a data (n being the number of all observations)."@en ;
  rdfs:subClassOf obo:OBI_0200181 , obo:OBI_0200184 .

obo:OBI_2000016 a rdfs:Class ;
  rdfs:label "erythrocyte specimen" ;
  rdfs:comment "A specimen that is derived from some erythrocytes"@en ;
  rdfs:subClassOf obo:OBI_0001468 .

obo:OBI_0001189 a rdfs:Class ;
  rdfs:label "epitope protection experiment based on survival" ;
  rdfs:comment "An epitope protection experiment that determines the success of the epitope intervention based on increased survival of the host."@en ;
  rdfs:subClassOf obo:OBI_0001184 .

obo:OBI_0002598 a rdfs:Class ;
  rdfs:label "inverse polymerase chain reaction" ;
  rdfs:comment "A polymerase chain reaction which amplifies DNA with only one known sequence from which primers may be designed. A series of restriction digestions and ligations result in a looped DNA fragment which can be primed for PCR."@en ;
  rdfs:subClassOf obo:OBI_0000415 .

obo:UBERON_0001811 a rdfs:Class ;
  rdfs:label "conjunctiva" ;
  rdfs:comment "The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001076 a rdfs:Class ;
  rdfs:label "incubator shaker" ;
  rdfs:comment "An incubating device that provides shaking motion for biomedical applications (e.g., cell cultures)."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0003921 a rdfs:Class ;
  rdfs:label "PacBio Sequel IIe" ;
  rdfs:comment "A DNA sequencer that is manufactured by the Pacific Biosciences corporation, built upon single molecule real-time sequencing technology, that shares the SMRT Cell design and chemistry of the Sequel II and adds on-instrument computational processing to generate highly accurate (\"HiFi\") long reads."@en ;
  rdfs:subClassOf obo:OBI_0003923 .

obo:OBI_2100399 a rdfs:Class ;
  rdfs:label "lipid panel reflex direct venous blood triglyceride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of triglyceride in venous blood as part of a Lipid panel reflex direct order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100029 .

obo:OBI_0002483 a rdfs:Class ;
  rdfs:label "spike-in dilution factor"@en ;
  rdfs:comment "A data item that indicates the dilution of spike-in added to a specimen."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0302736 a rdfs:Class ;
  rdfs:label "DNA damage comet assay" ;
  rdfs:comment "A cell based DNA damage assay that measures DNA damage (DNA breakage) in eucaryotic cells exposed to a challenge by determining the size and shape of DNA migration by detecting fluorescently labeled DNA from a cell placed in an electric field using gel electrophoresis"@en ;
  rdfs:subClassOf obo:OBI_0001501 , obo:OBI_0003721 .

obo:OBI_0001366 a rdfs:Class ;
  rdfs:label "epitope specific RANTES production by T cells" ;
  rdfs:comment "A process of RANTES production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071609 , obo:OBI_0001193 .

obo:OBI_0003911 a rdfs:Class ;
  rdfs:label "urea nitrogen concentration assay" ;
  rdfs:comment "A urea nitrogen assay that measures the abundance of urea nitrogen in a specimen"@en ;
  rdfs:subClassOf obo:OBI_0003910 .

obo:PATO_0002203 a rdfs:Class ;
  rdfs:label "right handedness" ;
  rdfs:comment "Handedness where the organism preferentially uses the right hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot." ;
  rdfs:subClassOf obo:PATO_0002201 .

obo:OBI_0001729 a rdfs:Class ;
  rdfs:label "quenching assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A fluorescence quenching assay that measures the dissociation constant [KD] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001635 , obo:OBI_0001708 .

obo:OBI_0002123 a rdfs:Class ;
  rdfs:label "IHC slide staining"@en ;
  rdfs:comment "A staining using labeled antibodies, i.e. the analytical part of immunohistochemistry. The staining is applied to fixed specimens on slides to identify biomarkers in tissues."@en ;
  rdfs:subClassOf obo:OBI_0302887 .

obo:OBI_0001049 a rdfs:Class ;
  rdfs:label "chip spotting device" ;
  rdfs:comment "A device for dropping and immobilizing a solution of biomolecules, for example, nucleic acids such as probe DNA, mRNA, and peptide nucleic acid (PNA), and proteins on a DNA microarray surface to manufacture a DNA microarray."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:CHEBI_47775 a rdfs:Class ;
  rdfs:label "high-density lipoprotein cholesterol" ;
  rdfs:comment "Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL)." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2100023 a rdfs:Class ;
  rdfs:label "protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000940 a rdfs:Class ;
  rdfs:label "optical microscope" ;
  rdfs:comment "A microscope that produces an image of an object by targeting it with an electro-magnetic beam in the visible frequency range"@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:OBI_0000442 a rdfs:Class ;
  rdfs:label "obsolete_heart" ;
  rdfs:comment "The heart is a muscular organ found in all vertebrates that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000475 a rdfs:Class ;
  rdfs:label "Bruker AutoClean system" ;
  rdfs:comment "NMR tubes are often used once and discarded, creating needless waste. With the Bruker BioSpin Autoclean system you can now recycle 5mm, 3mm, or 5mm/3mm step-down (Wilmad 520-1B) NMR tubes. AutoClean NMR Tube Washing System is a simple way to recoup the substantial investment your organization makes in quality NMR tubes, and cut back on needless waste material."@en ;
  rdfs:subClassOf obo:OBI_0000498 .

obo:OBI_0002484 a rdfs:Class ;
  rdfs:label "star algorithm"@en ;
  rdfs:comment "A reference genome transcriptome alignment algorithm that is a standalone RNA-seq alignment algorithm that uses uncompressed suffix arrays and a mapping algorithm similar to those used in large-scale genome alignment tools to align RNA-seq reads to a genomic reference."@en ;
  rdfs:subClassOf obo:OBI_0002478 .

obo:OBI_0002641 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells using survival."@en ;
  rdfs:subClassOf obo:OBI_0001492 , obo:OBI_0003474 .

obo:GO_0019815 a rdfs:Class ;
  rdfs:label "B cell receptor complex" ;
  rdfs:comment "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." ;
  rdfs:subClassOf obo:OBI_1110022 .

obo:GO_0035944 a rdfs:Class ;
  rdfs:label "perforin production" ;
  rdfs:comment "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001544 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a cell-lysate-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to cell-lysate-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001988 .

obo:OBI_0200157 a rdfs:Class ;
  rdfs:label "data vector reduction objective"@en ;
  rdfs:comment "Data vector reduction is a data transformation objective in which k m-dimensional input vectors are reduced to j m-dimensional output vectors, where j is smaller than k."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0001098 a rdfs:Class ;
  rdfs:label "ultrasound machine" ;
  rdfs:comment "A device that is used to visualize subcutaneous body structures including tendons, muscles, joints, vessels and internal organs."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0000413 a rdfs:Class ;
  rdfs:label "cell cycle synchronization"@en ;
  rdfs:comment "a process with the objective to obtain a cell culture in which all cells are in the same stage of the cell cycle"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003036 a rdfs:Class ;
  rdfs:label "Plasmodium gametocyte detection assay" ;
  rdfs:comment "An assay that detects Plasmodium gametocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003038 .

obo:UBERON_0001893 a rdfs:Class ;
  rdfs:label "telencephalon" ;
  rdfs:comment "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:OBI_0001208 a rdfs:Class ;
  rdfs:label "epitope specific T cell activation" ;
  rdfs:comment "A process of T cell activation resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0042110 .

obo:OBI_2100149 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0002196 a rdfs:Class ;
  rdfs:label "Sakura Low profile Accu-Edge microtome blade" ;
  rdfs:comment "A microtome blade that is manufactured by Feather and is disposable. The ultra-sharp blades section specimens without striations, distortion or chattering."@en ;
  rdfs:subClassOf obo:OBI_0002195 .

obo:OBI_0002501 a rdfs:Class ;
  rdfs:label "bile specimen" ;
  rdfs:comment "A specimen that is derived from bile."@en ;
  rdfs:subClassOf obo:OBI_0002504 .

obo:OBI_0003120 a rdfs:Class ;
  rdfs:label "epitope:MHC:TCR complex" ;
  rdfs:comment "A complex of molecular entities which is the result of a T cell receptor binding to a MHC-epitope complex."@en ;
  rdfs:subClassOf obo:COB_0000080 .

obo:GO_0032629 a rdfs:Class ;
  rdfs:label "interleukin-25 production" ;
  rdfs:comment "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0001887 a rdfs:Class ;
  rdfs:label "email address of Bioinformatics Resource Center contact person"@en ;
  rdfs:comment "An email address of the person who is contact representative of a Bioinformatics Resource Center"@en ;
  rdfs:subClassOf obo:IAO_0000429 .

obo:OBI_0001113 a rdfs:Class ;
  rdfs:label "microplate washer" ;
  rdfs:comment "A device that is used to wash immunoassays in microwell strips and plates with professional accuracy. WHAT IS PROFESSIONAL ACCURACY??"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002039 a rdfs:Class ;
  rdfs:label "assay for transposase-accessible chromatin using sequencing" ;
  rdfs:comment "An assay to capture the location of open chromatin, DNA-binding proteins, individual nucleosomes and chromatin compaction at nucleotide resolution by Tn5 transposase insertion."@en ;
  rdfs:subClassOf obo:OBI_0003686 .

obo:OBI_2100307 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood methemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of methemoglobin in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100040 .

obo:OBI_0000965 a rdfs:Class ;
  rdfs:label "lyophilized specimen" ;
  rdfs:comment "a specimen that is output of a lyophilization storage process in which specimen is lyophilized for storage."@en ;
  rdfs:subClassOf obo:OBI_0001472 , obo:OBI_0100051 .

obo:OBI_0002630 a rdfs:Class ;
  rdfs:label "Illumina NovaSeq 6000" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation, with two flow cells and an output of up to 6000 Gb (32-40 B reads per run). The sequencer utilizes synthesis technology and patterned flow cells to optimize throughput and even spacing of sequencing clusters."@en ;
  rdfs:subClassOf obo:OBI_0003685 .

obo:OBI_0003473 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells using survival."@en ;
  rdfs:subClassOf obo:OBI_0003463 , obo:OBI_0003472 .

obo:OBI_2100366 a rdfs:Class ;
  rdfs:label "venous blood nucleated RBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of nucleated RBCs in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_1110184 a rdfs:Class ;
  rdfs:label "epitope specific GM-CSF release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce GM-CSF resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032604 , obo:OBI_0001193 .

obo:OBI_0003071 a rdfs:Class ;
  rdfs:label "participant identifier" ;
  rdfs:comment "A symbol that denotes a participant under investigation."@en ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:OBI_0002804 a rdfs:Class ;
  rdfs:label "nitrile glove" ;
  rdfs:comment "A personal protective glove which is made out of nitrile rubber."@en ;
  rdfs:subClassOf obo:OBI_0002799 .

obo:OBI_2100271 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_2100394 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid basophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of basophils in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003021 , obo:OBI_0003232 .

obo:OBI_0000453 a rdfs:Class ;
  rdfs:label "measure function"@en ;
  rdfs:comment "Measure function is a function that is borne by a processed material  and realized in a process in which information about some entity is expressed relative to some reference."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:RO_0000079 a rdf:Property ;
  rdfs:label "function of"@en ;
  rdfs:comment "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000464 a rdfs:Class ;
  rdfs:label "Bruker autosampler" ;
  rdfs:comment "A Bruker autosampler is an autosampler made by Bruker."@en ;
  rdfs:subClassOf obo:OBI_0000555 .

obo:OBI_0200198 a rdfs:Class ;
  rdfs:label "obsolete tandem mass spectrometry" ;
  rdfs:comment "Tandem mass spectrometry is a data transformation that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:CHEBI_37989 a rdfs:Class ;
  rdfs:label "Cy5 dye" ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:OBI_0001533 a rdfs:Class ;
  rdfs:label "data storage service" ;
  rdfs:comment "A storage service in which a service consumer provides data as input which a service provider stores and returns as output in its original form."@en ;
  rdfs:subClassOf obo:OBI_0001530 .

obo:OBI_0001468 a rdfs:Class ;
  rdfs:label "cell specimen" ;
  rdfs:comment "A specimen primarily composed of a cell or cells collected from a multicellular organism or a cell culture."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002541 a rdfs:Class ;
  rdfs:label "spleen specimen" ;
  rdfs:comment "A specimen that is derived from spleen."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001352 a rdfs:Class ;
  rdfs:label "allele information"@en ;
  rdfs:comment "a genetic alteration information that about one of two or more alternative forms of a gene or marker sequence and differing from other alleles at one or more mutational sites based on sequence. Polymorphisms are included in this definition."@en ;
  rdfs:subClassOf obo:OBI_0001364 .

obo:OBI_0000145 a rdfs:Class ;
  rdfs:label "pathologist role"@en ;
  rdfs:comment "a worker role of being responsible for making the histopathology diagnoses associated with data from a study; this activity occurs outside the study timeline"@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:GO_0000785 a rdfs:Class ;
  rdfs:label "chromatin" ;
  rdfs:comment "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." ;
  rdfs:subClassOf obo:GO_0005575 .

obo:OBI_0002816 a rdfs:Class ;
  rdfs:label "chromatography vial" ;
  rdfs:comment "A vial with cap and container material suited to optical, sanitary and handling requirements of chromatography."@en ;
  rdfs:subClassOf obo:OBI_0000601 .

obo:OBI_0000842 a rdfs:Class ;
  rdfs:label "informing subject of study arm" ;
  rdfs:comment "A planned process with the objective to make the subject aware of which study arm they are participating in."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001753 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific granulocyte colony stimulating factor production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects granulocyte colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001600 , obo:OBI_0600031 .

obo:OBI_0001404 a rdfs:Class ;
  rdfs:label "genetic characteristics information"@en ;
  rdfs:comment "a data item that is about genetic material including polymorphisms, disease alleles, and haplotypes."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0600036 a rdfs:Class ;
  rdfs:label "establishing cell culture" ;
  rdfs:comment "a process through which a new type of cell culture or cell line is created, either through the isolation and culture of one or more cells from a fresh source, or the deliberate experimental modification of an existing cell culture (e.g passaging a primary culture to become a secondary culture or line, or the immortalization or stable genetic modification of an existing culture or line)."@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_2100203 a rdfs:Class ;
  rdfs:label "venous blood 25-hydroxyvitamin D2 assay" ;
  rdfs:comment "An analyte assay that measures the abundance of 25-hydroxyvitamin D2 in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:PATO_0002193 a rdfs:Class ;
  rdfs:label "electric charge" ;
  rdfs:comment "A molecular quality that inheres in a molecular entity by virtue of the overall electric charge of the molecule, which is due to a comparison between the total number of electrons and the total number of protons." ;
  rdfs:subClassOf obo:COB_0000502 .

obo:PATO_0002242 a rdfs:Class ;
  rdfs:label "velocity" ;
  rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's rate of change of the position." ;
  rdfs:subClassOf obo:PATO_0001906 .

obo:OBI_0003094 a rdfs:Class ;
  rdfs:label "fluorescence in-situ hybridization assay" ;
  rdfs:comment "An in-situ hybridization assay in which fluorescently labeled molecules are used to localize specific DNA or RNA sequences."@en ;
  rdfs:subClassOf obo:OBI_0001686 .

obo:CHEBI_59051 a rdfs:Class ;
  rdfs:label "diethyl pyrocarbonate" ;
  rdfs:comment "The diethyl ester of dicarbonic acid." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:NCBITaxon_33208 a rdfs:Class ;
  rdfs:label "Metazoa" ;
  rdfs:subClassOf obo:NCBITaxon_33154 .

obo:OBI_0000630 a rdfs:Class ;
  rdfs:label "hematology assay" ;
  rdfs:comment "An assay that studies phenotypes of an organism involving its blood and blood producing organs using a variety of techniques and instruments"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002443 a rdfs:Class ;
  rdfs:label "methidiumpropyl-EDTA-iron(II) footprinting assay" ;
  rdfs:comment "A footprinting assay that determines protein-binding sites on DNA by partial cleavage of ligand-protected DNA restriction fragments with methidium-propyl-EDTA (MPE). MPE-Fe(II) in the presence of oxygen efficiently catalyzes the non-specific clevage of DNA."@en ;
  rdfs:subClassOf obo:OBI_0002162 .

obo:OBI_0003694 a rdfs:Class ;
  rdfs:label "longitudinal investigation"@en ;
  rdfs:comment "An investigation that involves repeated observations of the same variables (e.g., people) over long periods of time."@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_0002783 a rdfs:Class ;
  rdfs:label "lower respiratory tract specimen" ;
  rdfs:comment "A specimen that is derived from the lower respiratory tract."@en ;
  rdfs:subClassOf obo:OBI_2000005 .

obo:OBI_0400089 a rdfs:Class ;
  rdfs:label "Reflection" ;
  rdfs:comment "A Reflection is a sorter manufactured by iCyte. It uses digital signal processing, and can be configured with lasers of the users choice from among these excitation wavelengths: 355, 405,488, 532, 635nm. It accommodates up to 48 traditional PMTs. Options include an acousto-optical tunable filter (AOTF) and 16 channel spectrometer (370 to 730 nm). The various detection components can be uniquely configured across multiple Highly Automated Parallel Sorting (HAPS) modules. The Reflection can be used to analyse, sort, and collect cells."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0002167 a rdfs:Class ;
  rdfs:label "subcellular protein localization assay" ;
  rdfs:comment "A protein localization assay that determines the specific subcellular location of a protein. The location is visualized through electron microscopy."@en ;
  rdfs:subClassOf obo:OBI_0002165 .

obo:OBI_0003003 a rdfs:Class ;
  rdfs:label "landing arthropod specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process that occurs while the arthropods land on a surface."@en ;
  rdfs:subClassOf obo:OBI_0002904 .

obo:OBI_0001301 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interleukin-16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001280 .

obo:OBI_0000678 a rdfs:Class ;
  rdfs:label "portioning objective" ;
  rdfs:comment "A material separation objective aiming to separate material into multiple portions, each of which contains a similar composition of the input material."@en ;
  rdfs:subClassOf obo:OBI_0000639 .

obo:OBI_0000824 a rdfs:Class ;
  rdfs:label "recombinant YAC cloning" ;
  rdfs:comment "Recombinant YAC cloning is a  process with the objective to insert genetic material into a yeast artificial chromosome vector for future replication of the inserted material"@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_0003621 a rdfs:Class ;
  rdfs:label "antibody purification of HLA protein complex with A29 serotype" ;
  rdfs:comment "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A29 serotype, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003617 .

obo:COB_0001000 a rdfs:Class ;
  rdfs:label "exposure of organism"@en ;
  rdfs:comment "A process during which an organism comes into contact with another entity."@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBI_0400029 a rdfs:Class ;
  rdfs:label "CytoSub" ;
  rdfs:comment "A CytoSub is a flow_cytometer_analyser manufactured by Cyto Buoy Inc. They are a single laser, multi parameter instrument. Various types of micro-laser are offered; available measuring parameters are forward light scatter, side scatter, and fluorescence (max. 9 colour bands). The current series have 5 parameters. The CytoSub is the submersible version equipped with a high pressure sample inlet loop and a high pressure housing to allow underwater operation down to 200 m, lowered on a cable or mounted on a flooded underwater vehicle."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_2000009 a rdfs:Class ;
  rdfs:label "bodily fluid specimen" ;
  rdfs:comment "A specimen that is derived from some bodily fluid"@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100181 a rdfs:Class ;
  rdfs:label "arterial blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0001082 a rdfs:Class ;
  rdfs:label "protein separation apparatus" ;
  rdfs:comment "A device that is used for the separation of proteins."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0002765 a rdfs:Class ;
  rdfs:label "microbiome protein expression profiling assay" ;
  rdfs:comment "A protein expression profiling assay of microbial proteins extracted from a microbioal community of mixed species from a given microbiome."@en ;
  rdfs:subClassOf obo:OBI_0000615 .

obo:CL_0000097 a rdfs:Class ;
  rdfs:label "mast cell" ;
  rdfs:comment "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." ;
  rdfs:subClassOf obo:CL_0000738 .

obo:OBI_1110046 a rdfs:Class ;
  rdfs:label "organ harvesting"@en ;
  rdfs:comment "The process of removing an organ from its source organism"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_2100004 a rdfs:Class ;
  rdfs:label "potassium(1+) assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium(1+)"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000608 a rdfs:Class ;
  rdfs:label "hydrogen generator" ;
  rdfs:comment "A gas generator that generates hydrogen gas."@en ;
  rdfs:subClassOf obo:OBI_0000507 .

obo:OBI_2100377 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0001558 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring half life to determine direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures half life to detect the direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001990 .

obo:OBI_0003395 a rdfs:Class ;
  rdfs:label "Affymetrix Rhesus Macaque Genome Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix,which is a single-labeled high-density oligonucleotide array, designed to study gene expression in the rhesus animal model and to interrogate rhesus transcripts orthologous to the 3' end of human transcripts. The array consists of over 52,000 probe sets representing more than 20,000 genes, and several relevant viral organisms for studying host-disease immune response."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0003891 a rdfs:Class ;
  rdfs:label "6A3 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 6-aminopyridine-3-carboxylic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001194 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects transforming growth factor-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001264 , obo:OBI_0600031 .

obo:PATO_0001020 a rdfs:Class ;
  rdfs:label "damage" ;
  rdfs:comment "A structural quality inhering in a bearer by virtue of whether the bearer has been harmed or injured or spoiled." ;
  rdfs:subClassOf obo:PATO_0000141 .

obo:OBI_0001657 a rdfs:Class ;
  rdfs:label "ELISA measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001703 .

obo:OBI_0000494 a rdfs:Class ;
  rdfs:label "liquid chromatography autosampler" ;
  rdfs:comment "Designed to perform capillary LC with injection of sample volumes ranging from nL to L."@en ;
  rdfs:subClassOf obo:OBI_0000485 .

obo:OBI_0002384 a rdfs:Class ;
  rdfs:label "niece clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female child of a sibling."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0003527 a rdfs:Class ;
  rdfs:label "gait assessment" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's manner or pattern of walking."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0400078 a rdfs:Class ;
  rdfs:label "obscuration bar" ;
  rdfs:comment "An obscuration bar is a an optical subsystem which is a strip of metal or other material that serves to block out direct light from the illuminating beam. The obscuration bar prevents the bright light scattered in the forward directions from burning out the collection device."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0002537 a rdfs:Class ;
  rdfs:label "thyroid gland specimen" ;
  rdfs:comment "A specimen that is derived from thyroid gland."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:NCBITaxon_12637 a rdfs:Class ;
  rdfs:label "Dengue virus" ;
  rdfs:subClassOf obo:NCBITaxon_11050 .

obo:OBI_0400119 a rdfs:Class ;
  rdfs:label "microarray wash station" ;
  rdfs:comment "A device that is used to wash Affymetrix-type arrays."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_1110118 a rdfs:Class ;
  rdfs:label "P815 cell line"@en ;
  rdfs:comment "A cell line derived from mouse mastocytoma."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0600000 a rdfs:Class ;
  rdfs:label "adding substance to cell culture"@en ;
  rdfs:comment "is process in which a material substance is added to a cell culture"@en ;
  rdfs:subClassOf obo:OBI_0000274 .

obo:OBI_0001281 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific IP-10 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects IP-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001308 .

obo:OBI_0002905 a rdfs:Class ;
  rdfs:label "animal-biting arthropod specimen collection by aspiration" ;
  rdfs:comment "An arthropod specimen collection by aspiration that occurs while the arthropod is biting an animal."@en ;
  rdfs:subClassOf obo:OBI_0002912 .

obo:OBI_0000908 a rdfs:Class ;
  rdfs:label "labeled DNA extract" ;
  rdfs:comment "a labeled specimen that is the output of a labeling process and has grain labeled DNA to be able to detect DNA in future experiments."@en ;
  rdfs:subClassOf obo:OBI_0001143 .

obo:OBI_0002191 a rdfs:Class ;
  rdfs:label "courier tracking number"@en ;
  rdfs:comment "A centrally registered identifier symbol assigned by a courier organization in order to track the delivery of an item."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0001377 a rdfs:Class ;
  rdfs:label "organism status comparison design" ;
  rdfs:comment "A study design that compares samples from live and dead organisms."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0000839 a rdfs:Class ;
  rdfs:label "labeled oligonucleotide" ;
  rdfs:comment "a labeled oligonucleotide is a short nucleic acid which underwent a labeling process resulting in a radioactive isotope such as P32 or P33 added to its backbone for instance by end labeling with polynucleotide kinase which added radiolabeled ATP to the 5' end of oligonucleotide"@en ;
  rdfs:subClassOf obo:COB_0000026 , obo:OBI_0001936 .

obo:OBI_0003172 a rdfs:Class ;
  rdfs:label "thyroid stimulating hormone concentration assay" ;
  rdfs:comment "A thyroid stimulating hormone assay that measures the concentration of thyroid stimulating hormone in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100033 .

obo:OBI_0000366 a rdfs:Class ;
  rdfs:label "metabolite profiling assay" ;
  rdfs:comment "An assay that detects and identifies chemical entities resulting from biochemical and cellular metabolism"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001871 a rdfs:Class ;
  rdfs:label "LSRFortessa X-20" ;
  rdfs:comment "A flow cytometer analyzer manifactured by Becton ans Dickinson. Can be configured with up to 5 lasers, 488nm, 532 or 561 nm, 640 nm, 405 nm, 355 nm for measuring up to 20 parameters simultaneously."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0000598 a rdfs:Class ;
  rdfs:label "ozone-induced chemiluminescence detector" ;
  rdfs:comment "Although there are many direct ozone chemiluminescent reactions with various gaseous molecules, the incorporation of a conversion step to convert various non-chemiluminescent analytes to a species capable of reacting with ozone to produce chemiluminescence broadens the horizon of this technique tremendously. The conversion of nearly all nitrogen- and sulfur-containing compounds to their respective chemiluminescent species for universal nitrogen and sulfur detection has made nitrogen/sulfur chemiluminescence detection the most widely used analytical methods based upon ozone-induced chemiluminescence. In addition to non-chromatographic applications, nitrogen/sulfur chemiluminescence detection has been adapted to various chromatographic techniques from gas chromatography to liquid and supercritical fluid chromatography as specialized element-specific detectors. The characteristics of these detectors are evaluated and compared to other element-selective detection techniques. The unique features of the chemiluminescence detectors have made them powerful tools in many diverse fields of analytical chemistry."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_0001492 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection based on survival" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from other challenge using survival."@en ;
  rdfs:subClassOf obo:OBI_0001189 , obo:OBI_0003462 .

obo:OBI_0000550 a rdfs:Class ;
  rdfs:label "nitrogen generator" ;
  rdfs:comment "A gas generator that generates nitrogen gas."@en ;
  rdfs:subClassOf obo:OBI_0000507 .

obo:OBI_2100286 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0003485 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-25 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-25 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0003484 .

obo:OBI_0200169 a rdfs:Class ;
  rdfs:label "normalization data transformation"@en ;
  rdfs:comment "A normalization data transformation is a data transformation that has objective normalization."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:UPHENO_0056253 a rdfs:Class ;
  rdfs:label "increased number of material anatomical entity in the urine" ;
  rdfs:comment "The presence of an increased number of material anatomical entity in the urine." ;
  rdfs:subClassOf obo:UPHENO_0001001 .

obo:OBI_0001177 a rdfs:Class ;
  rdfs:label "RNA sequencing assay" ;
  rdfs:comment "An assay that determines the sequence of an RNA molecule."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_0002051 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from infectious challenge based on pathogen burden" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from pathogen challenge using pathogen burden."@en ;
  rdfs:subClassOf obo:OBI_0001186 , obo:OBI_0003465 .

obo:OBI_0003715 a rdfs:Class ;
  rdfs:label "vital sign assay" ;
  rdfs:comment "An assay of a organism to measure basic physiological functions such as breathing, pulse, etc. (phylum bilateral)."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001027 a rdfs:Class ;
  rdfs:label "Terbium RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using Terbium as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_1110203 a rdfs:Class ;
  rdfs:label "epitope specific IL-6 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-6 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032635 , obo:OBI_0001193 .

obo:OBI_0000951 a rdfs:Class ;
  rdfs:label "compound treatment design" ;
  rdfs:comment "an intervention design in which the treatment is the administration of a compound"@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:OBI_2100170 a rdfs:Class ;
  rdfs:label "arterial blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:OBI_0000532 a rdfs:Class ;
  rdfs:label "column cartridge" ;
  rdfs:comment "A device that binds the chromatography column and additional connector elements and / or valves or syringes into one physical unity for further processing."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0001247 a rdfs:Class ;
  rdfs:label "genotyping by high throughput sequencing assay" ;
  rdfs:comment "A genotyping assay that uses a high througput sequencer"@en ;
  rdfs:subClassOf obo:OBI_0000435 .

obo:OBI_0000429 a rdfs:Class ;
  rdfs:label "intraperitoneal administration" ;
  rdfs:comment "The administration of a substance into the peritoneum of an organism"@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0000565 a rdfs:Class ;
  rdfs:label "electrical conductivity detector" ;
  rdfs:comment "The electrical conductivity detector measures the conductivity of the mobile phase. There is usually background conductivity which must be backed-off by suitable electronic adjustments. If the mobile phase contains buffers, the detector gives a base signal that completely overwhelms that from any solute usually making detection impossible. Thus, the electrical conductivity detector a bulk property detector. and senses all ions whether they are from a solute or from the mobile phase. In order to prevent polarization of the sensing electrodes, AC voltages must be used and so it is the impedance not the resistance of the electrode system that is actually measured. From a physical chemistry stand point the conductivity of a solution is more important than its resistance. However, it is the resistance (impedance) of the electrode system that determines the current across it. The resistance of any conductor varies directly as its length and inversely as its cross sectional area."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001811 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-27 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-27 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001198 , obo:OBI_0003115 .

obo:OBI_0001712 a rdfs:Class ;
  rdfs:label "obsolete B cell epitope direct binding assay" ;
  rdfs:comment "A direct binding assay using a assay"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002916 a rdfs:Class ;
  rdfs:label "human-biting outdoor arthropod specimen collection by aspiration" ;
  rdfs:comment "An arthropod specimen collection by aspiration designed to catch specimens that are in the process of biting a human outside a building."@en ;
  rdfs:subClassOf obo:OBI_0002914 .

obo:MRO_0001790 a rdfs:Class ;
  rdfs:label "rat MHC class I protein complex" ;
  rdfs:subClassOf obo:MRO_0001355 .

obo:OBI_0200094 a rdfs:Class ;
  rdfs:label "logarithmic transformation"@en ;
  rdfs:comment "A logarithmic transformation is a data transformation consisting in the application of the logarithm function with a given base a (where a>0 and a is not equal to 1) to a (one dimensional) positive real number input. The logarithm function with base a can be defined as the inverse of the exponential function with the same base. See e.g. http://en.wikipedia.org/wiki/Logarithm."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0000684 a rdfs:Class ;
  rdfs:label "specimen collection objective" ;
  rdfs:comment "A objective specification that is fulfilled by obtaining a material entity for potential use as an input upon which measurements or observations are performed."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_2100059 a rdfs:Class ;
  rdfs:label "automated differential venous blood lymphocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of lymphocytes in venous blood as part of a automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003024 , obo:OBI_0003040 .

obo:OBI_0002737 a rdfs:Class ;
  rdfs:label "organism detection by cytological chromosome examination assay" ;
  rdfs:comment "An organism detection assay that is based on analysis of polytene chromosomes through cytological examination of the banding pattern of the species."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:GO_0008217 a rdfs:Class ;
  rdfs:label "regulation of blood pressure" ;
  rdfs:comment "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0000847 a rdfs:Class ;
  rdfs:label "test substance role" ;
  rdfs:comment "A role born by a material entity and realized in a process where the substance is used as specified as the independent variable for an investigation"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003355 a rdfs:Class ;
  rdfs:label "image data set analysis" ;
  rdfs:comment "The process of deriving a data item from an image data set using computer algorithms. The produced data item can be an image data set, data measurement, or any other data item."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001792 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects macrophage inflammatory protein-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001333 .

obo:OBI_0002019 a rdfs:Class ;
  rdfs:label "transcription factor binding site identification by ChIP-Seq assay" ;
  rdfs:comment "A transcription factor binding site assay that utilizes ChIP-seq technology."@en ;
  rdfs:subClassOf obo:OBI_0000291 , obo:OBI_0000716 .

obo:OBI_0003426 a rdfs:Class ;
  rdfs:label "amylase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of amylase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0500020 a rdfs:Class ;
  rdfs:label "time series design" ;
  rdfs:comment "Groups of assays that are related as part of a time series."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0200124 a rdfs:Class ;
  rdfs:label "kurtosis calculation"@en ;
  rdfs:comment "A kurtosis calculation is a descriptive statistics calculation defined as a parameter that measures how large or small the tails of a distribution are relative to the mean.  For details, see http://davidmlane.com/hyperstat/A53638.html"@en ;
  rdfs:subClassOf obo:OBI_0200086 , obo:OBI_0200184 .

obo:IAO_0000098 a rdfs:Class ;
  rdfs:label "data format specification"@en ;
  rdfs:comment """A data format specification is the information content borne by the document published defining the specification.
Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file"""@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:CHEBI_4551 a rdfs:Class ;
  rdfs:label "digoxin" ;
  rdfs:comment "A  cardenolide glycoside that is digitoxin β-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, <em>Digitalis lanata</em>, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000728 a rdfs:Class ;
  rdfs:label "rodent care" ;
  rdfs:comment "rodent care  is the process by which rodents are being provided with a controlled living environment while kept in captivity for the purpose of research."@en ;
  rdfs:subClassOf obo:OBI_0000708 .

obo:OBI_0000110 a rdfs:Class ;
  rdfs:label "pH indicator dye role"@en ;
  rdfs:comment "the role of a dye that is realized when the dye is used in an experiment to measure the pH in a material entity"@en ;
  rdfs:subClassOf obo:OBI_0000250 .

obo:OBI_0001274 a rdfs:Class ;
  rdfs:label "genotyping by array assay" ;
  rdfs:comment "A genotyping assay that uses an array"@en ;
  rdfs:subClassOf obo:OBI_0000435 , obo:OBI_0001985 .

obo:OBI_0001108 a rdfs:Class ;
  rdfs:label "nucleic acid sequencer" ;
  rdfs:comment "An device that is used to determine the order of nucleotides in nucleic acid sequences."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:NCBITaxon_10407 a rdfs:Class ;
  rdfs:label "Hepatitis B virus" ;
  rdfs:subClassOf obo:NCBITaxon_2732514 .

obo:OBI_2100318 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:COB_0000014 a rdfs:Class ;
  rdfs:label "obsolete macromolecular entity" .

obo:CHEBI_28689 a rdfs:Class ;
  rdfs:label "dehydroepiandrosterone" ;
  rdfs:comment "An androstanoid that is androst-5-ene substituted by a β-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000377 a rdfs:Class ;
  rdfs:label "perturb function"@en ;
  rdfs:comment "A perturb function is a function that disrupts the normal function of a system induced through either internal or external means.  External means of perturbation include: (1) displacement fields in the physical sense - e.g., temperature change, osmotic shock, pressure change; (2) application of small molecules such as drugs or toxins to perturb the function of specific pathways or application of surfactants to perturb the normal function of plasma membrane.  Internal means of perturbation include: (1) manipulation of gene function via gene knockout or transcript knockdown via RNAi; (2) directed genetic mutation leading to minimal aa alterations that interfere with peptide function."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0001118 a rdfs:Class ;
  rdfs:label "multichannel pipette" ;
  rdfs:comment "A pipetting system that has a plurality of tip fittings and is used for multi-well plate applications."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001663 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific granulysin release by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects epitope specific granulysin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001810 .

obo:OBI_0001190 a rdfs:Class ;
  rdfs:label "epitope treatment experiment" ;
  rdfs:comment "An epitope intervention experiment that tests the ability of inducing an epitope immune response to treat an existing disease  in the host."@en ;
  rdfs:subClassOf obo:OBI_0001178 .

obo:OBI_0002373 a rdfs:Class ;
  rdfs:label "aunt clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in the female sibling of a parent."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0003790 a rdfs:Class ;
  rdfs:label "antibody-dependent complement deposition assay" ;
  rdfs:comment "An assay measuring antibody-dependent complement-dependent cytotoxicity."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003006 a rdfs:Class ;
  rdfs:label "well net for arthropod immatures" ;
  rdfs:comment "A device that is designed for the collection of arthropod larvae or pupae from water and consists of a conical net."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000702 a rdfs:Class ;
  rdfs:label "454 Genome Sequencer FLX" ;
  rdfs:comment "is a DNA sequencer which was first manufactured by 454 Life Science Corporation in 2008 and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are controlled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information.  It has the ability to sequence 400-600 million base pairs per run with 400-500 base pair read lengths."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_2100276 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_2100138 a rdfs:Class ;
  rdfs:label "random electrolytes urine potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in urine as part of a random electrolytes order"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100004 .

obo:OBI_0001882 a rdfs:Class ;
  rdfs:label "target material in specimen specification"@en ;
  rdfs:comment "A plan specification which specifies the type of material that will be assayed in an investigation."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0000113 a rdfs:Class ;
  rdfs:label "sequence feature identification objective"@en ;
  rdfs:comment "Sequence_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features exhibited at the level of a macromolecular sequence, e.g. nucleic acid, protein, polysaccharide."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0003401 a rdfs:Class ;
  rdfs:label "Illumina HumanHT-12 V4.0 expression beadchip" ;
  rdfs:comment "An Illumina BeadChip which employs direct-hybridization assay, for whole-genome expression profiling and expression-based quantitative trait loci (eQTL) studies. This BeadChip contains 12 arrays, each featuring more than 48,000 probes, targeting more than 31,000 annotated genes, providing genome-wide coverage of well-characterized genes, gene candidates, and splice variants."@en ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:OBI_0000709 a rdfs:Class ;
  rdfs:label "yeast artificial chromosome vector" ;
  rdfs:comment "a double-stranded DNA that was engineered to contain a yeast origin of replication, encodes for a selectable gene product, contains a cloning site, and has yeast telomerase sequences"@en ;
  rdfs:subClassOf obo:CHEBI_4705 , obo:OBI_0000737 .

obo:GO_0060259 a rdfs:Class ;
  rdfs:label "regulation of feeding behavior" ;
  rdfs:comment "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:NCBITaxon_9031 a rdfs:Class ;
  rdfs:label "Gallus gallus" ;
  rdfs:subClassOf obo:NCBITaxon_32524 .

obo:OBI_0001327 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific lymphotoxin A production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects lymphotoxin A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001400 .

obo:OBI_0003314 a rdfs:Class ;
  rdfs:label "mapping RNA-genome interactions assay" ;
  rdfs:comment "A nuclear ligation assay for probing RNA-DNA interactions in the nucleus. Nuclei are crosslinked, and RNA fragments are ligated to proximal DNA fragments via a special linker molecule. After reverse transcription, high-throughput sequencing is performed."@en ;
  rdfs:subClassOf obo:OBI_0002438 .

obo:OBI_0002468 a rdfs:Class ;
  rdfs:label "base calling algorithm"@en ;
  rdfs:comment "An algorithm that assigns nucleotides to temporal or spatial peaks generated by a detector, such as peaks of light intensities generated by a DNA sequencer"@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:IDO_0000586 a rdfs:Class ;
  rdfs:label "infection"@en ;
  rdfs:comment "A part of an extended organism that itself has as part a population of one or more infectious agents and that (1) exists as a result of processes initiated by members of the infectious agent population and is (2) clinically abnormal in virtue of the presence of this infectious agent population, or (3) has a disposition to bring clinical abnormality to immunocompetent organisms of the same Species as the host (the organism corresponding to the extended organism) through transmission of a member or offspring of a member of the infectious agent population."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0002067 a rdfs:Class ;
  rdfs:label "dermis" ;
  rdfs:comment "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003117 a rdfs:Class ;
  rdfs:label "3D molecular structure determination assay" ;
  rdfs:comment "An assay that determines the 3-dimensional configuration of a molecular entity or molecular complex."@en ;
  rdfs:subClassOf obo:OBI_0600045 .

obo:OBI_0001770 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific vascular endothelial growth factor production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects vascular endothelial growth factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001570 .

obo:OBI_0001641 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific complement-dependent cytotoxicity" ;
  rdfs:comment "A B cell epitope specific activation of additional immune response assay that detects complement-dependent cytotoxicity in vitro ."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001704 .

obo:OBI_0200012 a rdfs:Class ;
  rdfs:label "loess scale group transformation two-channel"@en ;
  rdfs:comment "A loess scale group transformation two-channel is a loess scale group transformation consisting in the application of a scale adjustment following a loess group transformation two-channel, to render the M group variances similar."@en ;
  rdfs:subClassOf obo:OBI_0200025 .

obo:OBI_0000514 a rdfs:Class ;
  rdfs:label "Bruker AMX series NMR instrument" ;
  rdfs:comment "A series of older Bruker NMR magnets, now out of production. The Bruker AMX500 has proven an extremely reliable workhorse, with excellent lineshape yielding superior water suppression even without gradients. The Oxford 11.7 Tesla 5.2 cm bore magnet rests on a TMC vibration damping table. Homogeneity is controlled by a BSN-18 and BSN-2 with 19 shim controls. In addition to the 5 mm triple resonance probe, the AMX is equipped with a 10mm broadband observe probe."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:OBI_0600017 a rdfs:Class ;
  rdfs:label "assay detecting a molecular label" ;
  rdfs:comment "An assay that detects the presence or a quality of a molecular label which is a proxy for the detection of the molecular target to which the label is attached"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002927 a rdfs:Class ;
  rdfs:label "dipper for arthropod immatures" ;
  rdfs:comment "A device that is designed for the collection of arthropod larvae or pupae from water and has the shape of a ladle or a pan."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000508 a rdfs:Class ;
  rdfs:label "column jacket" ;
  rdfs:comment "A column jacket is a piece of column chromatography equipment that covers a column in order to ensure thermoisolation and create a controllable thermostatic microenvironment."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0000438 a rdfs:Class ;
  rdfs:label "DNA sequence variation detection assay" ;
  rdfs:comment "An assay that measures changes (expansion, amplification, deletion, mutation) in the sequence of a DNA molecule."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0400067 a rdfs:Class ;
  rdfs:label "long pass filter" ;
  rdfs:comment "A long pass filter is an optical filter that passes high wavelengths of light but attenuates (or reduces) wavelengths lower than the cutoff frequency. A long pass filter with a cutoff of 500 nm would pass all wavelengths greater than 500 nm."@en ;
  rdfs:subClassOf obo:OBI_0400079 .

obo:OBI_0001947 a rdfs:Class ;
  rdfs:label "sequence annotation provider"@en ;
  rdfs:comment "A person or organization reporting the feature annotation results from the analysis of a macromolecular sequence."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003328 a rdfs:Class ;
  rdfs:label "magnetic resonance image data set" ;
  rdfs:comment "An image data set whose information content originates from some MR imaging assay and is about some MRI participant."@en ;
  rdfs:subClassOf obo:OBI_0003327 .

obo:OBI_0001060 a rdfs:Class ;
  rdfs:label "spot cutter" ;
  rdfs:comment "A robotic device that is used to excise spots from gels."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002618 a rdfs:Class ;
  rdfs:label "national biomedical registry"@en ;
  rdfs:comment "A national registry that contains information about individuals that was accumulated for a biomedical purpose, such as diagnoses, treatments, or outcomes."@en ;
  rdfs:subClassOf obo:OBI_0002617 .

obo:OBI_0000503 a rdfs:Class ;
  rdfs:label "Bruker LC-NMR platform" ;
  rdfs:comment "The LC-NMR/MS setup was first introduced by Bruker BioSpin in 1999. An LC-NMR system including a Bruker Peak Sampling Unit (BPSU-36) was coupled with a Bruker Daltonics esquire series ion trap mass spectrometer via a Bruker NMR-MS interface (BNMI). Since October 2004 the Bruker Daltonics microTOF-LC time-of-flight mass spectrometer can also be integrated in an LC-NMR setup."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:OBI_0002939 a rdfs:Class ;
  rdfs:label "resting arthropod trap" ;
  rdfs:comment "An arthropod trap that is designed to be attractive to an arthropod as a place to rest during a period of inactivity."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0002759 a rdfs:Class ;
  rdfs:label "ribosomal RNA-depleted RNA sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay in which highly abundant ribosomal RNAs are removed from total RNA before sequencing, resulting in more efficient transcript/gene detection."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0001617 a rdfs:Class ;
  rdfs:label "PubMed ID"@en ;
  rdfs:comment "A CRID symbol that is sufficient to look up a citation from the PubMed, a literature database of life sciences and biomedical information."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0001826 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-21 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001237 , obo:OBI_0600031 .

obo:OBI_0001893 a rdfs:Class ;
  rdfs:label "organization of specimen collector"@en ;
  rdfs:comment "An organization that is the affiliation of the person collecting the specimen"@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0001129 a rdfs:Class ;
  rdfs:label "voltage clamp device" ;
  rdfs:comment "A device that is used to measure the ion currents across the membrane of excitable cells, such as neurons, while holding the membrane voltage at a set level."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0400038 a rdfs:Class ;
  rdfs:label "FACS Canto2" ;
  rdfs:comment "A FACS_Canto2 is a flow_cytometer_analyser manufactured by BD. It features digital electronics, two solid state lasers at 488 and 633 nm with the option for a third 405 nm laser, and filters and collectors for measuring up to 8 fluorescent paramters with either the 2 or 3 laser option. The FACS_Canto2 is an analyser usually used in clinical applications."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0000050 a rdfs:Class ;
  rdfs:label "obsolete_platform" ;
  rdfs:comment "A platform is an object_aggregate that is the set of instruments and software needed to perform a process. definition_source: OBI."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000912 a rdfs:Class ;
  rdfs:label "X-ray crystallography 3D molecular structure determination assay" ;
  rdfs:comment "A 3D molecular structure determination assay in which the diffraction of pattern of X-ray beams in a crystal of purified material entities is used to resolve the 3-dimensional structure of the material entity of interest."@en ;
  rdfs:subClassOf obo:OBI_0003117 .

obo:OBI_0001500 a rdfs:Class ;
  rdfs:label "coelution assay measuring MHC ligand processing and presentation using T cell recognition of HPLC fractionated eluate compared to synthetic ligand" ;
  rdfs:comment "A MHC ligand processing and presentation assay in which an HPL chromatography is run to separate an input mixture of ligands eluted from MHC into fractions. These fractions are tested for recognition by T cells and compared to the recognition of a synthetic ligand that is presumed to be the recognized epitope. Identical HPLC fractionation and T cell recognition patterns confirm that the specific ligand was presented by MHC molecules."@en ;
  rdfs:subClassOf obo:OBI_1110125 .

obo:OBI_0003030 a rdfs:Class ;
  rdfs:label "oligonucleotide primer set" ;
  rdfs:comment "A processed material that consists of oligonucleotides that bear a primer role."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:RO_0000053 a rdf:Property ;
  rdfs:label "has characteristic"@en ;
  rdfs:comment "Inverse of characteristic_of"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0500016 a rdfs:Class ;
  rdfs:label "fractional factorial design" ;
  rdfs:comment "A fractional factorial design is_a study design in which only an adequately chosen fraction of the treatment combinations required for the complete factorial experiment is selected to be run"@en ;
  rdfs:subClassOf obo:OBI_0500014 .

obo:OBI_0003197 a rdfs:Class ;
  rdfs:label "estradiol concentration assay" ;
  rdfs:comment "An estradiol assay that measures the concentration of estradiol in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003196 .

obo:OBI_0002790 a rdfs:Class ;
  rdfs:label "N95 respirator" ;
  rdfs:comment "A face mask that meets the U.S. National Institute for Occupational Safety and Health (NIOSH) N95 classification of air filtration, meaning that it filters at least 95% of incoming airborne particles."@en ;
  rdfs:subClassOf obo:OBI_0002787 .

obo:OBI_2100196 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0002727 a rdfs:Class ;
  rdfs:label "insecticide resistance by short interspersed elements PCR assay" ;
  rdfs:comment "An insecticide resistance assay that is based on monitoring known mutations by PCR amplification of short interspersed elements (SINEs)."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0002696 .

obo:OBI_0001775 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 19 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-C motif) ligand 19 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0400108 a rdfs:Class ;
  rdfs:label "heating block" ;
  rdfs:comment "A heating block is an instrument or part of an instrument which raises or maintains the temperature of a sample to a defined constant temperature during certain parts of an assay"@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_0002180 a rdfs:Class ;
  rdfs:label "inside-out patch clamp assay" ;
  rdfs:comment "A patch-clamp assay where a patch of the membrane is attached to the patch pipette, detached from the rest of the cell, and the cytosolic surface of the membrane is exposed to the external media, or bath. This provides the experimenter has access to the intracellular surface of the membrane via the bath and can manipulate the environment at the intracellular surface of single ion channels. For example, channels that are activated by intracellular ligands can then be studied through a range of ligand concentrations."@en ;
  rdfs:subClassOf obo:OBI_0002177 .

obo:OBI_0002710 a rdfs:Class ;
  rdfs:label "Centre for Disease Control and Prevention bottle bioassay" ;
  rdfs:comment "A direct insecticide resistance diagnostic assay performs in a glass bottle coated with insecticides for detecting resistance to insecticides in vector populations."@en ;
  rdfs:subClassOf obo:OBI_0002707 .

obo:OBI_0003794 a rdfs:Class ;
  rdfs:label "bacterial lipopolysaccharide detection in feces assay" ;
  rdfs:comment "An analyte assay measuring bacterial lipopolysaccharide in a feces sample."@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003237 .

obo:GO_0042756 a rdfs:Class ;
  rdfs:label "drinking behavior" ;
  rdfs:comment "The specific behavior of an organism relating to the intake of liquids, especially water." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001781 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects macrophage inflammatory protein-1 gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001456 , obo:OBI_0003115 .

obo:GO_0032618 a rdfs:Class ;
  rdfs:label "interleukin-15 production" ;
  rdfs:comment "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0001296 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-17 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001295 , obo:OBI_0003115 .

obo:OBI_0100055 a rdfs:Class ;
  rdfs:label "obsolete_cell line cell" ;
  rdfs:comment "A material entity that represents generations of a primary culture."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003194 a rdfs:Class ;
  rdfs:label "creatine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatine"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_2100326 a rdfs:Class ;
  rdfs:label "intraoperative venous blood PTH assay" ;
  rdfs:comment "An analyte assay that measures the abundance of PTH in venous blood as part of a intraoperative order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100034 .

obo:OBI_0002378 a rdfs:Class ;
  rdfs:label "sister clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female sibling."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0001475 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from infectious challenge based on pathogen burden" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from pathogen challenge using pathogen burden."@en ;
  rdfs:subClassOf obo:OBI_0001186 , obo:OBI_0003460 .

obo:GO_0099536 a rdfs:Class ;
  rdfs:label "synaptic signaling" ;
  rdfs:comment "Cell-cell signaling to, from or within a synapse." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0001316 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-21 production by T cells" ;
  rdfs:comment "A process of interleukin-21 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032625 , obo:OBI_0001193 .

obo:OBI_0001999 a rdfs:Class ;
  rdfs:label "3D molecular structure determination assay of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A 3D structure determination of bound molecular complex assay that characterizes the 3-dimensional structure of a T cell epitope:MHC:TCR complex."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001145 , obo:OBI_0003128 .

obo:UBERON_0001062 a rdfs:Class ;
  rdfs:label "anatomical entity" ;
  rdfs:comment "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." .

obo:OBI_0000211 a rdfs:Class ;
  rdfs:label "proxy respondent role"@en ;
  rdfs:comment "Proxy respondent is a worker role of describing patient's symptoms or condition to medical personnel"@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:PATO_0001241 a rdfs:Class ;
  rdfs:label "physical object quality" ;
  rdfs:comment "A quality which inheres in a continuant." ;
  rdfs:subClassOf obo:PATO_0000001 .

obo:OBI_0001594 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring competitive binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that detects loss of binding of a known reference ligand to cell-bound-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001550 .

obo:GO_0001906 a rdfs:Class ;
  rdfs:label "cell killing" ;
  rdfs:comment "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0000064 a rdfs:Class ;
  rdfs:label "positive reference substance role"@en ;
  rdfs:comment "a reference role in which the characteristics or responses elicited by the substance playing the reference substance role are used to establish a \"100%\" response"@en ;
  rdfs:subClassOf obo:OBI_0000025 .

obo:OBI_1110125 a rdfs:Class ;
  rdfs:label "assay measuring MHC ligand processing and presentation" ;
  rdfs:comment "A MHC ligand assay that determines what ligands are processed and loaded onto MHC molecules by eluting ligands and identifying them."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002075 .

obo:OBI_0003183 a rdfs:Class ;
  rdfs:label "mean cell hemoglobin assay" ;
  rdfs:comment "A hemoglobin assay that measures the average concentration of hemoglobin in a population of erythrocytes."@en ;
  rdfs:subClassOf obo:OBI_2100014 .

obo:OBI_2100298 a rdfs:Class ;
  rdfs:label "bone profile venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a bone profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_0003142 a rdfs:Class ;
  rdfs:label "quantitative binding datum" ;
  rdfs:comment "A binding datum that is expressed using numbers."@en ;
  rdfs:subClassOf obo:OBI_0001181 .

obo:OBI_0003299 a rdfs:Class ;
  rdfs:label "DamID-seq" ;
  rdfs:comment "A DNA adenine methyltransferase identification (DamID) assay in which DamID-generated DNA fragments undergo high-throughput sequencing to determine a protein's DNA-binding site."@en ;
  rdfs:subClassOf obo:OBI_0003298 .

obo:GO_0035393 a rdfs:Class ;
  rdfs:label "chemokine (C-X-C motif) ligand 9 production" ;
  rdfs:comment "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0400146 a rdfs:Class ;
  rdfs:label "multispectral imaging flow cytometer" ;
  rdfs:comment "A multispectral_imaging_flow_cytometer is an instrument which combines quantitative image analysis and flow cytometry in a single platform. It measures the amount, location and movement of molecules on, in, or between cells, and  the location and co-localization of multiple markers on or in cells. It can also quantitate morphologically distinct cell subpopulations."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0002395 a rdfs:Class ;
  rdfs:label "number of live births" ;
  rdfs:comment "A measurement datum of the total number of live births a female has had."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:PR_000025477 a rdfs:Class ;
  rdfs:label "ribonuclease V1 (cobra)" ;
  rdfs:comment "A protein with ribonuclease activity that is a constituent of cobra venom." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0400112 a rdfs:Class ;
  rdfs:label "liquid handler" ;
  rdfs:comment "A device that is used for automated liquid transfer and handling."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001226 a rdfs:Class ;
  rdfs:label "environmental history design" ;
  rdfs:comment "A study design in which some aspect of the organism's environmental history is studied, such as exposure to teratogen, radiation, climate etc."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0600006 a rdfs:Class ;
  rdfs:label "killing"@en ;
  rdfs:comment "A protocol application in which an organism is intentionally put to death"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:UBERON_0001797 a rdfs:Class ;
  rdfs:label "vitreous humor" ;
  rdfs:comment "A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OBI_0002017 a rdfs:Class ;
  rdfs:label "histone modification identification by ChIP-Seq assay" ;
  rdfs:comment "An epigenetic modification assay that identifies regions containing specific histones and their modifications using ChIP-Seq techniques."@en ;
  rdfs:subClassOf obo:OBI_0000716 , obo:OBI_0002020 .

obo:OBI_0002552 a rdfs:Class ;
  rdfs:label "testis specimen" ;
  rdfs:comment "A specimen that is derived from testis."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001580 a rdfs:Class ;
  rdfs:label "material transport service" ;
  rdfs:comment "A service in which a service provider facilitates the transport of some material entity to a specified destination for the service consumer."@en ;
  rdfs:subClassOf obo:OBI_0001528 .

obo:OBI_0000579 a rdfs:Class ;
  rdfs:label "Varian UNITY spectrometer" ;
  rdfs:comment "The predecessor series of the Varian UNITY INOVA spectrometer."@en ;
  rdfs:subClassOf obo:OBI_0000611 .

obo:OBI_0003014 a rdfs:Class ;
  rdfs:label "uric acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of uric acid"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_2100388 a rdfs:Class ;
  rdfs:label "blood gas arterial blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0001135 a rdfs:Class ;
  rdfs:label "balance" ;
  rdfs:comment "A measuring instrument that is used to determine the weight or mass of an object."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0003925 a rdfs:Class ;
  rdfs:label "read-based taxonomic classification" ;
  rdfs:comment "A data transformation that assigns taxonomic labels to individual sequencing reads, or to a set of reads, by comparison against a reference sequence database and without prior assembly."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:PR_000016261 a rdfs:Class ;
  rdfs:label "serotransferrin" ;
  rdfs:comment "A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0001606 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that detects direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001550 .

obo:MRO_0001793 a rdfs:Class ;
  rdfs:label "rat MHC class II protein complex with RT1-A haplotype" ;
  rdfs:subClassOf obo:MRO_0001356 .

obo:OBI_0200161 a rdfs:Class ;
  rdfs:label "quantile number of false positives correction method"@en ;
  rdfs:comment "A quantile number of false positives correction method is a MTP that controls for the pth quantile of the distribution of the number of false positives out of the total number of tests performed'"@en ;
  rdfs:subClassOf obo:OBI_0200089 .

obo:OBI_0002692 a rdfs:Class ;
  rdfs:label "polymerase chain reaction assay" ;
  rdfs:comment "An assay that uses polymerase chain reaction technique to amplify DNA."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002924 a rdfs:Class ;
  rdfs:label "BG-Counter" ;
  rdfs:comment "A device manufactured by BioGents that is designed to count mosquitoes passing through the device, differentiating the mosquitoes from other arthropods."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_2100034 a rdfs:Class ;
  rdfs:label "prostate-specific antigen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of prostate-specific antigen"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:OBI_0302840 a rdfs:Class ;
  rdfs:label "curated information"@en ;
  rdfs:comment "An information content entity that has undergone a digital curation performed by a curator for accuracy checks and compliance with curation requirements. Information which has been assessed for accuracy by domain experts."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0001987 a rdfs:Class ;
  rdfs:label "assay measuring the association constant [KA] of a MHC:ligand complex" ;
  rdfs:comment "A MHC binding constant determination assay measuring equilibrium association constant (KA)."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001553 .

obo:OBI_2100106 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood basophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of basophils in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003021 , obo:OBI_0003040 .

obo:OBI_0000605 a rdfs:Class ;
  rdfs:label "chart recorder" ;
  rdfs:comment "The chart recorder is a device that transduces signal-intensities into a graphical peak output: As the separated components of the gas sample emerge into the detector, the change in voltage in the detecting bridge circuit causes a representative peak to be drawn on a chart recorder. The position of the peak along the time axis of the chart measures the component's retention time, which identifies the component. This is directly related to carrier gas flow rate, temperature and column packing and dimensions. The area under each peak is proportional to the concentration of the component of the sample. The area of the peaks inscribed on the chart recorder can be determined by multiplying the height of the peak in mm, by the width of the peak in mm at 1/2 the peak height. The calibration curves for use with the chart recorder are therefore peak area plotted against concentration."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_2100221 a rdfs:Class ;
  rdfs:label "random venous blood amikacin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of amikacin in venous blood as part of a random order"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_2100163 a rdfs:Class ;
  rdfs:label "venous blood lactic acid assay" ;
  rdfs:comment "An assay that measures lactic acid in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100042 .

obo:OBI_0002400 a rdfs:Class ;
  rdfs:label "neither hysterectomy nor oophorectomy history" ;
  rdfs:comment "A gynecologic surgery history in which a woman has not had either a hysterectomy or an oophorectomy."@en ;
  rdfs:subClassOf obo:OBI_0002397 .

obo:OBI_0003415 a rdfs:Class ;
  rdfs:label "peripheral blood mononuclear cell specimen" ;
  rdfs:comment "A processed specimen that is extracted from whole blood using gradient centrifugation that separates the blood into a layer of peripheral blood mononuclear cells under the top layer of plasma. It contains lymphocytes, monocytes or macrophages that are critical components in the immune system."@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0200176 a rdfs:Class ;
  rdfs:label "Fisher's exact test" ;
  rdfs:comment "Fisher's exact test is a data transformation used to determine if there are nonrandom associations between two Fisher's exact test is a statistical significance test used in the analysis of contingency tables where sample sizes are small where the significance of the deviation from a null hypothesis can be calculated exactly, rather than relying on an approximation that becomes exact in the limit as the sample size grows to infinity, as with many statistical tests."@en ;
  rdfs:subClassOf obo:OBI_0000673 .

obo:OBI_0400071 a rdfs:Class ;
  rdfs:label "MACS Quant" ;
  rdfs:comment "A MACS Quant is a flow_cytometer_analyser manufactured by Miltenyi. It uses digital electronics, and has three lasers of wavelengths 405 nm, 488 nm, and 635 nm. It has filters and detectors to collect 7 fluorescent parameters and 2 scatter parameters. The MACS Quant is an analyser usually used in research applications."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0000611 a rdfs:Class ;
  rdfs:label "Varian NMR instrument" ;
  rdfs:comment "An NMR instrument that is manufactured by Varian."@en ;
  rdfs:subClassOf obo:OBI_0000566 .

obo:OBI_0000638 a rdfs:Class ;
  rdfs:label "gas purifier" ;
  rdfs:comment "Gas purifiers are instruments used for the removal of gas impurities like hydrocarbons, oxygen, and moisture from carrier gas and fuel gases for GC or GC-MS systems."@en ;
  rdfs:subClassOf obo:OBI_0000542 .

obo:OBI_0001021 a rdfs:Class ;
  rdfs:label "RNASE T2 structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAse T2 as reagent and enzymatic probe"@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:OBI_2100297 a rdfs:Class ;
  rdfs:label "urine sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in urine"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100002 .

obo:IAO_0000178 a rdfs:Class ;
  rdfs:label "material information bearer"@en ;
  rdfs:comment "A material entity in which a concretization of an information content entity inheres."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0200017 a rdfs:Class ;
  rdfs:label "cosine transformation"@en ;
  rdfs:comment "A cosine transformation is a data transformation which consists in applying the cosine function to a (one dimensional) real number input. The cosine function is one of the basic trigonometric functions and a definition is provided, e.g., at http://mathworld.wolfram.com/Cosine.html."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0001511 a rdfs:Class ;
  rdfs:label "disposition to be a product of antigen processing and presentation" ;
  rdfs:comment "A disposition of a material entity to be presented by MHC molecules on the cell surface as a result of antigen processing by an antigen presenting cell."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_0000218 a rdfs:Class ;
  rdfs:label "investigation results report"@en ;
  rdfs:comment "An investigation report is a report on the results of an investigation."@en ;
  rdfs:subClassOf obo:IAO_0000088 .

obo:OBI_0400007 a rdfs:Class ;
  rdfs:label "analog-to-digital converter" ;
  rdfs:comment "An analog-to-digital_converter is an instrument that converts an infinite resolution analog signal to a finite resolution digital signal."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:COB_0000021 a rdfs:Class ;
  rdfs:label "gross anatomical part"@en ;
  rdfs:comment "A part of a multicellular organism that is a collection of cell components that are not all contained in one cell."@en ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_0001251 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-13 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002985 a rdfs:Class ;
  rdfs:label "magnetic resonance imaging assay" ;
  rdfs:comment "An imaging assay in which nuclear magnetic resonance is used to produce information about the interior structure and composition of an input material entity."@en ;
  rdfs:subClassOf obo:OBI_0000185 .

obo:OBI_0001199 a rdfs:Class ;
  rdfs:label "in vivo design" ;
  rdfs:comment "A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0000584 a rdfs:Class ;
  rdfs:label "anion exchange column" ;
  rdfs:comment "An anion exchange column is a chromatography column that is used in anion exchange chromatography and which enables the separation of anion mixtures."@en ;
  rdfs:subClassOf obo:OBI_0000560 .

obo:PATO_0001375 a rdfs:Class ;
  rdfs:label "haploid" ;
  rdfs:comment "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." ;
  rdfs:subClassOf obo:PATO_0001393 .

obo:OBI_0002185 a rdfs:Class ;
  rdfs:label "current clamp assay" ;
  rdfs:comment "The current clamp technique records the membrane potential by injecting current into a cell through the recording electrode. Unlike in the voltage clamp mode, where the membrane potential is held at a level determined by the experimenter, in \"current clamp\" mode the membrane potential is free to vary, and the amplifier records whatever voltage the cell generates on its own or as a result of stimulation. This technique is used to study how a cell responds when electric current enters a cell; this is important for instance for understanding how neurons respond to neurotransmitters that act by opening membrane ion channels."@en ;
  rdfs:subClassOf obo:OBI_0000447 .

obo:OBI_0001393 a rdfs:Class ;
  rdfs:label "comparative genomic hybridization by array assay" ;
  rdfs:comment "An assay that measures changes in DNA sequence copy number using a microarray. For example the analysis of LOH in tumor cells vs a non diseased sample or the comparison of clinical isolated of disease causing bacteria."@en ;
  rdfs:subClassOf obo:OBI_0000435 , obo:OBI_0001985 .

obo:OBI_0000812 a rdfs:Class ;
  rdfs:label "measuring neural activity in the caudate nucleus assay" ;
  rdfs:comment "An assay that measures neural activity in the caudate nucleus"@en ;
  rdfs:subClassOf obo:OBI_0000454 .

obo:OBI_0003895 a rdfs:Class ;
  rdfs:label "1M6 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 1-methyl-6-nitroisatoic anhydride as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0003025 a rdfs:Class ;
  rdfs:label "monocyte assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of monocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:PATO_0001339 a rdfs:Class ;
  rdfs:label "biomaterial purity" ;
  rdfs:comment "A composition quality inhering in an bearer by virtue of the bearer's homogeneity of a biomaterial." ;
  rdfs:subClassOf obo:PATO_0000025 .

obo:OBI_0001066 a rdfs:Class ;
  rdfs:label "top loading balance" ;
  rdfs:comment "A balance that consists of a metal plate on which to place an object and a digital readout of the measurement of its mass."@en ;
  rdfs:subClassOf obo:OBI_0001135 .

obo:OBI_0000489 a rdfs:Class ;
  rdfs:label "nitrogen phosphorous detector" ;
  rdfs:comment "The nitrogen phosphorus detector (NPD) (sometimes called the thermionic detector) is a very sensitive, specific detector the design of which, is based on the FID. Physically the sensor appears to be very similar to the FID but, in fact, operates on an entirely different principle. The nitrogen phosphorous detector (sometimes called the thermionic detector) is a very sensitive but specific detector that responds almost exclusively to nitrogen and phosphorous compounds. It is based on the flame ionization detector but differs in that it contains a rubidium or cesium silicate (glass) bead situated in a heater coil, a little distance from the hydrogen flame. If the detector is to respond to both nitrogen and phosphorous then the hydrogen flow should be minimal so that the gas does not ignite at the jet. If the detector is to respond to phosphorous only, a large flow of hydrogen is used which is burnt at the jet. The heated bead emits electrons by thermionic emission. These electrons are collected under a potential of a few volts by an appropriately placed anode, and provides a background current. When a solute containing nitrogen or phosphorous is eluted from the column, the partially combusted nitrogen and phosphorous materials are adsorbed on the surface of the bead. The adsorbed material reduces the work function of the surface and, as consequence, the emission of electrons is increased which raises the current collected at the electrode. The sensitivity of the detector to phosphorous is about 10-12 gram per ml and for nitrogen about 10-11 gram per ml at a signal to nose ratio of 2. The alkali bead as a finite life and needs regular replacement."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_0302732 a rdfs:Class ;
  rdfs:label "solvent role"@en ;
  rdfs:comment "solvent role is a role which inheres in a molecular entity capable of ensuring the dissolution of another chemical entity and realized by the process of solvation"@en ;
  rdfs:subClassOf obo:OBI_0003610 .

obo:OBI_0003114 a rdfs:Class ;
  rdfs:label "Illumina MiniSeq" ;
  rdfs:comment "A small benchtop DNA sequencer which is manufactured by the Illumina corporation with integrated cluster generation, sequencing and data analysis. The sequencer accommodates various flow cell configurations and can produce up to 25M single reads or 50M paired-end reads per run."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0000109 a rdfs:Class ;
  rdfs:label "obsolete biological vector role" ;
  rdfs:comment "a biological vector role is a material to be added role that is realized by the process of transmitting material to the organism that is the target of the transmission."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003260 a rdfs:Class ;
  rdfs:label "umbilical cord blood microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of an umbilical cord blood microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003244 , obo:OBI_0003259 .

obo:OBIB_0000659 a rdfs:Class ;
  rdfs:label "fixed tissue specimen"@en ;
  rdfs:comment "A processed specimen that is the output of a fixation process."@en ;
  rdfs:subClassOf obo:OBI_0000953 .

obo:OBI_0001640 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific immunoglobulin-mediated antigen activation" ;
  rdfs:comment "A B cell epitope dependent biological activity determination assay that detects antigen activation."@en ;
  rdfs:subClassOf obo:OBI_0001706 .

obo:OBI_2100044 a rdfs:Class ;
  rdfs:label "vancomycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of vancomycin"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002000 a rdfs:Class ;
  rdfs:label "Illumina Genome Analyzer IIx" ;
  rdfs:comment "An Illumina Genome Analyzer II which is manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology. The Genome Analyzer IIx is the most widely adopted next-generation sequencing platform and proven and published across the broadest range of research applications."@en ;
  rdfs:subClassOf obo:OBI_0000703 .

obo:UBERON_0002391 a rdfs:Class ;
  rdfs:label "lymph" ;
  rdfs:comment "Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP]." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0002028 a rdfs:Class ;
  rdfs:label "SAGE ditag library preparation"@en ;
  rdfs:comment "A library preparation in which tags identifiying transcripts are created, ligated to form ditags, amplified, concatemerized and ligated into a vector to create a library."@en ;
  rdfs:subClassOf obo:OBI_0000711 .

obo:UBERON_0002097 a rdfs:Class ;
  rdfs:label "skin of body" ;
  rdfs:comment "The organ covering the body that consists of the dermis and epidermis." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0001421 a rdfs:Class ;
  rdfs:label "epitope specific interferon-beta production by T cells" ;
  rdfs:comment "A process of interferon-beta production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032608 , obo:OBI_0001193 .

obo:OBI_0002629 a rdfs:Class ;
  rdfs:label "direct RNA sequencing assay" ;
  rdfs:comment "An assay to study transcription through direct RNA sequence determination, without prior conversion of RNA molecules to cDNA."@en ;
  rdfs:subClassOf obo:OBI_0001177 .

obo:UBERON_0001567 a rdfs:Class ;
  rdfs:label "cheek" ;
  rdfs:comment "A fleshy subdivision of one side of the face bounded by an eye, ear and the nose." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:IAO_0000308 a rdfs:Class ;
  rdfs:label "figure"@en ;
  rdfs:comment "An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:CHEBI_33262 a rdfs:Class ;
  rdfs:label "elemental oxygen" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001859 a rdfs:Class ;
  rdfs:label "formaldehyde-assisted isolation of regulatory elements assay" ;
  rdfs:comment "An assay to determine the sequences of those DNA regions in the genome associated with regulatory activity."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_0003103 a rdfs:Class ;
  rdfs:label "periodic acid-Schiff staining assay" ;
  rdfs:comment "A histological assay which is used on tissue samples to demonstrate the presence of carbohydrates and carbohydrate compounds such as polysaccharides, mucin, glycogen, or fungal cell wall components."@en ;
  rdfs:subClassOf obo:OBI_0600020 .

obo:OBI_0001236 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-22 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001217 .

obo:BFO_0000141 a rdfs:Class ;
  rdfs:label "immaterial entity"@en .

obo:OBI_0001087 a rdfs:Class ;
  rdfs:label "lyophilizer" ;
  rdfs:comment "A device that is used to freeze dry material."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:GO_0032625 a rdfs:Class ;
  rdfs:label "interleukin-21 production" ;
  rdfs:comment "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:GO_0034061 a rdfs:Class ;
  rdfs:label "DNA polymerase activity" ;
  rdfs:comment "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0002007 a rdfs:Class ;
  rdfs:label "SOLiD 3 Plus System" ;
  rdfs:comment "A DNA sequencer which is manufacted by the Applied Biosystems corporation. Built upon SOLiD sequencing technology, the machine generates greater than 1 billion mappable reads per run."@en ;
  rdfs:subClassOf obo:OBI_0000696 .

obo:UBERON_0001088 a rdfs:Class ;
  rdfs:label "urine" ;
  rdfs:comment "Excretion that is the output of a kidney." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OBI_0000633 a rdfs:Class ;
  rdfs:label "column heater" ;
  rdfs:comment "The glass liner can be fitted with a separate heater and the volatilization temperature can, thus, be controlled. This flash heater system is available in most chromatographs. By using a syringe with a long needle, the tip can be made to penetrate past the liner and discharge its contents directly into the column packing. This procedure is called 'on-column injection' and, as it reduces peak dispersion on injection and thus, provides higher column efficiencies, is often the preferred procedure."@en ;
  rdfs:subClassOf obo:OBI_0000485 .

obo:OBI_0000616 a rdfs:Class ;
  rdfs:label "high resolution probe with automatic tuning and matching" ;
  rdfs:comment "The Automatic Tuning and Matching (ATM) option for AVANCE spectrometers is available for double resonance probes in fixed-frequency and broadband tunable configurations with either direct or indirect detection. Thus, for multinuclear operation, as often required for applications in inorganic chemistry, ATM facilitates the accurate setting of 90 degree pulse widths on both observe and decoupling channels for each chosen nucleus and each individual sample - even with full automation. Triple resonance probes in fixed-frequency configurations, as typically used for inverse detection with high-field systems."@en ;
  rdfs:subClassOf obo:OBI_0000480 .

obo:OBI_0002447 a rdfs:Class ;
  rdfs:label "suppression subtractive hybridization" ;
  rdfs:comment "An artificially induced nucleic acid hybridization that is performed to compare gene expression in different cell or tissue types based on normalization and suppression, which creates a subtracted cDNA or genomic DNA library."@en ;
  rdfs:subClassOf obo:OBI_0000253 .

obo:OBI_0200135 a rdfs:Class ;
  rdfs:label "edge quality calculation"@en ;
  rdfs:comment "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of one of the edge relationships in the network."@en ;
  rdfs:subClassOf obo:OBI_0200080 .

obo:OBI_0000801 a rdfs:Class ;
  rdfs:label "spike train datum" ;
  rdfs:comment "A measurement datum which represents information about an ordered series of action potentials in an organism's CNS measured over time."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0002389 a rdfs:Class ;
  rdfs:label "clinical history of repeated HIV assays" ;
  rdfs:comment "A clinical history in which there is repeated reactive screening assays for human immunodeficiency virus (1 or 2) antibodies regardless of the results of supplemental assays."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0001898 a rdfs:Class ;
  rdfs:label "comment on investigation"@en ;
  rdfs:comment "A textual entity that is about any of the aspects of an investigation worth noting"@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:CHEBI_37586 a rdfs:Class ;
  rdfs:label "sodium phosphate" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002056 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 17 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects production of chemokine (C-C motif) ligand 17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001157 a rdfs:Class ;
  rdfs:label "age since hatching measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since hatching, the process of emergence from an egg."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0001486 a rdfs:Class ;
  rdfs:label "disposition to be bound by an MHC protein complex" ;
  rdfs:comment "Is the disposition borne by a material entity that is realized in a process of being bound in the antigen binding grove of an MHC protein complex."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_0002902 a rdfs:Class ;
  rdfs:label "solar light source" ;
  rdfs:comment "A light source that light is produced from solar energy."@en ;
  rdfs:subClassOf obo:OBI_0400065 .

obo:UBERON_0000955 a rdfs:Class ;
  rdfs:label "brain" ;
  rdfs:comment "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:CL_0001064 a rdfs:Class ;
  rdfs:label "malignant cell" ;
  rdfs:comment "A neoplastic cell that is capable of entering a surrounding tissue" ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0003288 a rdfs:Class ;
  rdfs:label "multiplex real time reverse-transcription polymerase chain reaction assay" ;
  rdfs:comment "A real time reverse-transcription polymerase chain reaction assay in which multiple DNA sequences are amplified in a single cycle."@en ;
  rdfs:subClassOf obo:OBI_0000911 .

obo:OBI_0000938 a rdfs:Class ;
  rdfs:label "categorical measurement datum" ;
  rdfs:comment "A measurement datum that is reported on a categorical scale."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0001410 a rdfs:Class ;
  rdfs:label "translation profiling design" ;
  rdfs:comment "A study design in which surface-bound, translationally competent ribosome complexes are used to generate a translation profile for mRNA, where mRNA may be a single molecular species, or a combination of species, including complex mixtures such as those found in the set of mRNAs isolated from a cell or tissue. One or more components of the surface-bound ribosome complex may be labeled at specific positions to permit analysis of multiple or single molecules for determination of ribosomal conformational changes and translation kinetics. Translation profiles are used as the basis for comparison of an mRNA or set of mRNA species. The translation profile can be used to determine such characteristics as kinetics of initiation, kinetic of elongation, identity of the polypeptide product, and the like. Analysis of translation profiles may be used to determine differential gene expression, optimization of mRNA sequences for expression, screening drug candidates for an effect on translation."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001576 a rdfs:Class ;
  rdfs:label "obsolete purified MHC binding constant determination assay" ;
  rdfs:comment "An assay that measures the affinity of a ligand to a purified MHC complex preparation and that quantifies the affinity with a binding constant."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001630 a rdfs:Class ;
  rdfs:label "analytical chromatography" ;
  rdfs:comment "An analyte assay that uses a biomaterial's preferential affinity for either the mobile phase or the stationary phase to separate it from other materials and thereby detect its presence in an input material."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:CL_0000738 a rdfs:Class ;
  rdfs:label "leukocyte" ;
  rdfs:comment "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0003615 a rdfs:Class ;
  rdfs:label "antibody purification of MHC protein complex" ;
  rdfs:comment "A purification to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0001505 .

obo:OBI_0001345 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-C motif) ligand 4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:NCBITaxon_2732406 a rdfs:Class ;
  rdfs:label "Kitrinoviricota" ;
  rdfs:subClassOf obo:NCBITaxon_2559587 .

obo:OBI_2100304 a rdfs:Class ;
  rdfs:label "ABG/electrolytes arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a ABG/electrolytes order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBA_2060190 a rdfs:Class ;
  rdfs:label "brachioradialis functionality" ;
  rdfs:comment "The functionality of a brachioradialis." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:OBI_0400061 a rdfs:Class ;
  rdfs:label "jet_in_air_flow_chamber"@en ;
  rdfs:comment "A flow cell in which the cells are pinched off as droplets and allowed to drop through the air. The laser intersects with the cell in mid-air. A jet in air flow chamber allows the laser to intersect with the cells without any intermittent media other than air."@en ;
  rdfs:subClassOf obo:BFO_0000029 .

obo:OBI_0000828 a rdfs:Class ;
  rdfs:label "research organization" ;
  rdfs:comment "An organization formed with a goal to have its members conduct investigations"@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0003541 a rdfs:Class ;
  rdfs:label "ELISA measuring Orientia tsutsugamushi IgM antibody" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects the IgM antibody that binds Orientia tsutsugamushi."@en ;
  rdfs:subClassOf obo:OBI_0000661 .

obo:OBI_2100049 a rdfs:Class ;
  rdfs:label "mesothelial cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of mesothelial cells"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0001481 a rdfs:Class ;
  rdfs:label "lowess global transformation"@en ;
  rdfs:comment "A lowess transformation where the same normalization curve is used for all members of the data set; e.g. Features on an array, picked spots on a gel, or measured metabolites in a sample."@en ;
  rdfs:subClassOf obo:OBI_0001477 .

obo:OBI_0003090 a rdfs:Class ;
  rdfs:label "bulk RNA-seq assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay in which the sample that is sequenced is derived from a collection of cells, such as a tissue sample or entire cell culture, and therefore provides results representative of the aggregate of sample cells."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_2100117 a rdfs:Class ;
  rdfs:label "venous blood uric acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of uric acid in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003014 , obo:OBI_0003040 .

obo:OBI_0003462 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from other challenge" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from a challenge other than pathogen, infection, or tumor."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0002073 .

obo:OBI_0000521 a rdfs:Class ;
  rdfs:label "flame ionization detector" ;
  rdfs:comment "A flame ionization detector is a GC detector that consist of a hydrogen/air flame and a collector plate which are normally heated independently of the chromatographic oven. Heating is necessary in order to prevent condensation of water generated by the flame and also to prevent any hold-up of solutes as they pass from the column to the flame. There is an electrode above the flame to collect the ions formed at a hydrogen/air flame. The number of ions hitting the collector is measured and a signal is generated. Flame ionization detectors are most widely used and generally applicable for gas chromatography and hence is used for routine and general purpose analysis. It is easy to use but destructive of the sample."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_2100012 a rdfs:Class ;
  rdfs:label "platelet count assay" ;
  rdfs:comment "A cytometry assay that measures the count of platelets"@en ;
  rdfs:subClassOf obo:OBI_0003028 .

obo:OBI_2100369 a rdfs:Class ;
  rdfs:label "total venous blood homocysteine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of homocysteine in venous blood as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_0002153 a rdfs:Class ;
  rdfs:label "EBV IgM antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect immunoglobulin M (IgM) antibodies that bind to Epstein-Barr virus (EBV) antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0000449 a rdfs:Class ;
  rdfs:label "obsolete_defined_output" ;
  rdfs:comment "This is only a placeholder for defined classes, as are its siblings _defined_material and _defined protocol application. Its children should be defined classes constructed as output of a process."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001976 a rdfs:Class ;
  rdfs:label "hydrogen/deuterium exchange footprinting assay" ;
  rdfs:comment "A footprinting assay that uses a chemical reaction whereby a covalently bonded hydrogen atom is replaced by a deuterium atom, or vice versa in order to gather information about the solvent accessibility of parts of a molecule and thus its tertiary structure."@en ;
  rdfs:subClassOf obo:OBI_0002162 .

obo:NCBITaxon_2157 a rdfs:Class ;
  rdfs:label "Archaea" ;
  rdfs:subClassOf obo:COB_0000022 .

obo:CHEBI_31624 a rdfs:Class ;
  rdfs:label "fluorescein (lactone form)" ;
  rdfs:comment "A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy." ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:OBI_0200171 a rdfs:Class ;
  rdfs:label "partitioning data transformation"@en ;
  rdfs:comment "A partitioning data transformation is a data transformation that has objective partitioning."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0200006 a rdfs:Class ;
  rdfs:label "biexponential transformation"@en ;
  rdfs:comment "A biexponential transformation is a data transformation that, for each (one dimensional) real number input x, outputs an approximation (found, e.g. with the Newton's method) to a solution y of the equation B(y)-x=0, where B denotes a b transformation."@en ;
  rdfs:subClassOf obo:OBI_0200072 , obo:OBI_0200169 .

obo:OBI_0002996 a rdfs:Class ;
  rdfs:label "blood meal source role" ;
  rdfs:comment "A role borne by an organism that is gained during a process in which another organism ingests blood as food from the organism."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0200097 a rdfs:Class ;
  rdfs:label "non-negative matrix factorization"@en ;
  rdfs:comment "Non negative matrix factorization is a data transformation in which factorises a matrix and which forces that all elements must be equal to or greater than zero."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_2100232 a rdfs:Class ;
  rdfs:label "chem11 venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:CHEBI_9754 a rdfs:Class ;
  rdfs:label "tris" ;
  rdfs:comment "A primary amino compound that is <em>tert</em>-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7—9; p<em>K</em><small><sub>a</sub></small> = 8.3 at 20 °C; p<em>K</em><small><sub>a</sub></small> = 7.82 at 37 °C." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001522 a rdfs:Class ;
  rdfs:label "sequence assembly algorithm"@en ;
  rdfs:comment "An algorithm used to assemble individual sequence reads into larger contiguous sequences (contigs).  Assembly details include but are not limited to assembler type (overlap-layout-consensus, deBruijn), assembler version, and any relevant quality control information such as per cent known genes/ESTs captured."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0500025 a rdfs:Class ;
  rdfs:label "ethical standard compliance rule"@en ;
  rdfs:comment "an ethical standard compliance rule is_a *compliance rule* which enable a  *ethical compliance process* to occur"@en ;
  rdfs:subClassOf obo:OBI_0500024 .

obo:OBI_2100185 a rdfs:Class ;
  rdfs:label "vented blood gas arterial blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a vented blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0003272 a rdfs:Class ;
  rdfs:label "bacteria in lung datum" ;
  rdfs:comment "A lung microbiology datum that is about bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003256 .

obo:OBI_1110021 a rdfs:Class ;
  rdfs:label "infection process"@en ;
  rdfs:comment "the detrimental process in which an infectious agent colonizes or replicates in a host environment"@en ;
  rdfs:subClassOf obo:OBI_1110122 .

obo:OBI_0003581 a rdfs:Class ;
  rdfs:label "nasal aspirate microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a nasal aspirate microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 .

obo:OBI_0001305 a rdfs:Class ;
  rdfs:label "genotype information"@en ;
  rdfs:comment "a genetic characteristics information that is about the genetic material of an organism and minimally includes information about the genetic background and can in addition contain information about specific alleles, genetic modifications, etc."@en ;
  rdfs:subClassOf obo:OBI_0001404 .

obo:OBI_0002512 a rdfs:Class ;
  rdfs:label "bone marrow specimen" ;
  rdfs:comment "A specimen that is derived from bone marrow."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000627 a rdfs:Class ;
  rdfs:label "quaternary pump system" ;
  rdfs:comment "A pump system that pump and mix up to four different solvents in parallel."@en ;
  rdfs:subClassOf obo:OBI_0000589 .

obo:OBI_1110002 a rdfs:Class ;
  rdfs:label "obsolete_occurrence of disease" ;
  rdfs:comment "An occurrence of disease is a process involving pathologic changes within an organism"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:CL_0000794 a rdfs:Class ;
  rdfs:label "CD8-positive, alpha-beta cytotoxic T cell" ;
  rdfs:comment "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." ;
  rdfs:subClassOf obo:CL_0000625 .

obo:OBI_0000450 a rdfs:Class ;
  rdfs:label "regulatory agency"@en ;
  rdfs:comment "A regulatory agency is a organization that has responsibility over or for  the legislation (acts and regulations) for a given sector of the government."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_2100265 a rdfs:Class ;
  rdfs:label "tube 4 count cerebrospinal fluid cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of cells in cerebrospinal fluid as part of a tube 4 count order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003232 .

obo:OBI_0001786 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects inflammatory protein-1 gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001456 , obo:OBI_0600031 .

obo:OBI_1110187 a rdfs:Class ;
  rdfs:label "epitope specific IL-10 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-10 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032613 , obo:OBI_0001193 .

obo:OBI_0001919 a rdfs:Class ;
  rdfs:label "Carbon-copy chromosome conformation capture assay" ;
  rdfs:comment "An assay that measures the organization of chromosomes at the genome-wide scale."@en ;
  rdfs:subClassOf obo:OBI_0000626 , obo:OBI_0002692 .

obo:OBI_0003368 a rdfs:Class ;
  rdfs:label "detection technique" ;
  rdfs:comment "An assay (A) that is part of another assay (B), where the target entities of A and B are disjoint, and the target entity of A is a proxy for the target of assay B."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001409 a rdfs:Class ;
  rdfs:label "cell cycle design" ;
  rdfs:comment "A study design that assays events that occur in relation to the cell cycle, which is the period between the formation of a cell, by division of its mother cell and the time when the cell itself divides to form two daughter cells."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001905 a rdfs:Class ;
  rdfs:label "secondary cultured cell population" ;
  rdfs:comment "A cultured cell population that is derived through one or more passages in culture."@en ;
  rdfs:subClassOf obo:OBI_0100060 .

obo:OBI_0200034 a rdfs:Class ;
  rdfs:label "jackknifing method"@en ;
  rdfs:comment "Jacknifing is a re-sampling data transformation process used to estimate the precision of sampling statistics and is a resampling method"@en ;
  rdfs:subClassOf obo:OBI_0000792 .

obo:CL_0000010 a rdfs:Class ;
  rdfs:label "cultured cell" ;
  rdfs:comment "A cell in vitro that is or has been maintained or propagated as part of a cell culture." ;
  rdfs:subClassOf obo:CL_0000578 .

obo:OBI_0001262 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-27 production by T cells" ;
  rdfs:comment "A process of interleukin-27 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032631 , obo:OBI_0001193 .

obo:SO_0001248 a rdfs:Class ;
  rdfs:label "assembly" ;
  rdfs:comment "A region of the genome of known length that is composed by ordering and aligning two or more different regions." ;
  rdfs:subClassOf obo:SO_0001410 .

obo:OBI_0002371 a rdfs:Class ;
  rdfs:label "diagnosis of cancer" ;
  rdfs:comment "A diagnosis that is an assertion that a patient who is the subject of a diagnostic process has cancer."@en ;
  rdfs:subClassOf obo:OGMS_0000073 .

obo:OBI_0003802 a rdfs:Class ;
  rdfs:label "urine color assay" ;
  rdfs:comment "A histological assay with urine evaluant that measures color."@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_0600020 .

obo:OBI_0001285 a rdfs:Class ;
  rdfs:label "in vitro design" ;
  rdfs:comment "A study design that is done in a test tube or a culture dish, e.g. A bacterial invasion assay in an established cell culture."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001538 a rdfs:Class ;
  rdfs:label "training service" ;
  rdfs:comment "A service  in which the service provider offers educational materials or events, such as courses, workshops or graduate programs, to the service consumer."@en ;
  rdfs:subClassOf obo:OBI_0001173 .

obo:OBI_2100146 a rdfs:Class ;
  rdfs:label "Biosite cardiac panel arterial blood creatine kinase MB assay" ;
  rdfs:comment "An assay that measures creatine kinase MB in arterial blood as part of a Biosite cardiac panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100041 .

obo:PATO_0000918 a rdfs:Class ;
  rdfs:label "volume" ;
  rdfs:comment "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies." ;
  rdfs:subClassOf obo:PATO_0001710 .

obo:OBI_0003653 a rdfs:Class ;
  rdfs:label "fasting"@en ;
  rdfs:comment "A planned process in which an organism drinks only water and does not eat for a specified period of time."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_1110114 a rdfs:Class ;
  rdfs:label "contact to pathogen carrying biological vector"@en ;
  rdfs:comment "a process in which a vector carrying an infectious agent comes close enough to a potential host organism that a contact can result"@en ;
  rdfs:subClassOf obo:OBI_1110111 .

obo:OBI_0003271 a rdfs:Class ;
  rdfs:label "bacteria in endotracheal tube aspirate datum" ;
  rdfs:comment "An endotracheal tube aspirate microbiology datum that is about bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003255 .

obo:OBA_2060189 a rdfs:Class ;
  rdfs:label "tendon of biceps brachii functionality" ;
  rdfs:comment "The functionality of a tendon of biceps brachii." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:OBI_0003390 a rdfs:Class ;
  rdfs:label "Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray" ;
  rdfs:comment "A DNA microarray manufactured with Agilent 60-mer SurePrint technology which provides comprehensive coverage of genes and transcripts using the latest annotation databases. The SurePrint G3 Mouse Gene Expression 8x60K v2 Microarray features complete coverage of established RefSeq coding transcripts (NM) from the latest build and updated long non-coding RNA (lncRNA) content to ensure relevant research.Each glass slide formatted with eight high-definition 60K arrays."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:IAO_0000006 a rdfs:Class ;
  rdfs:label "narrative object"@en ;
  rdfs:comment "A narrative object is an information content entity that is a set of propositions."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003711 a rdfs:Class ;
  rdfs:label "grip strength assay" ;
  rdfs:comment "A nervous system functionality assessment that uses the grip strength of a lab animal to measure neuromuscular function."@en ;
  rdfs:subClassOf obo:OBI_0003533 .

obo:OBI_0002136 a rdfs:Class ;
  rdfs:label "RNA Integrity Number calculation"@en ;
  rdfs:comment "A data transformation using the RIN algorithm to generate a quality measure of RNA based on features from an electrophoretic trace."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0003282 a rdfs:Class ;
  rdfs:label "lung microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a lung specimen."@en ;
  rdfs:subClassOf obo:OBI_0003235 , obo:OBI_0003498 .

obo:OBI_0002722 a rdfs:Class ;
  rdfs:label "insecticide resistance by ligase detection reaction assay" ;
  rdfs:comment "An insecticide resistance assay that is based on monitoring known mutations using ligase detection reaction exquisitely discriminate between a mismatched and complementary DNA helix."@en ;
  rdfs:subClassOf obo:OBI_0002696 .

obo:OBI_0200023 a rdfs:Class ;
  rdfs:label "loess global transformation"@en ;
  rdfs:comment "A loess global transformation is a loess transformation where only one loess fitting is performed, utilizing one subset of (or possibly all of) the data points in the input so that there is only one resulting loess curve y=f(x) which is used for the transformation."@en ;
  rdfs:subClassOf obo:OBI_0200071 .

obo:OBI_0000536 a rdfs:Class ;
  rdfs:label "fraction collector" ;
  rdfs:comment "A fraction detector is a device that allows regular or specified samples to be taken from a column eluate and stored in a retrievable form. The storage vessels are usually small sample tubes or vials that are oriented in a rotating disk or in a moving belt, there movement usually being controlled by a microprocessor. On receiving a signal from the microprocessor, the next vial is placed under the column outlet and the eluate collected until receiving another signal from the computer. Once the properties of the chromatogram that describes the separation has been ascertained, then the collection program can be defined. The fractions can be collected on a basis of time either at regular intervals or a specific times to collect specific peaks. Alternatively the fractions can be collected by monitoring the detector output and when a peak starts to elute the fraction collector is activated and the peak collected in a specific vial. When the peak returns to base line the column eluate is then directed to waste until the next peak starts eluting. Fraction collectors are in common use with most liquid chromatographs. They are used to collect samples for further purification, subsequent examination by spectroscopic techniques or for biological or organoleptic testing."@en ;
  rdfs:subClassOf obo:OBI_0000485 .

obo:GO_0009566 a rdfs:Class ;
  rdfs:label "fertilization" ;
  rdfs:comment "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001800 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-8 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-8 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001218 , obo:OBI_0600031 .

obo:OBI_1110010 a rdfs:Class ;
  rdfs:label "disposition to cause an allergic reaction"@en ;
  rdfs:comment "The role borne by a material entity that is realized when it is recognized by the immune system and results in the occurrence of an allergic disease."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:GO_0032634 a rdfs:Class ;
  rdfs:label "interleukin-5 production" ;
  rdfs:comment "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:GO_0035398 a rdfs:Class ;
  rdfs:label "helper T cell enhancement of T cell mediated immune response" ;
  rdfs:comment "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell." ;
  rdfs:subClassOf obo:GO_0035397 .

obo:OBI_0001569 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring binding off rate [koff] to determine direct binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures binding off rate [koff] to detect direct binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001993 .

obo:OBI_0600039 a rdfs:Class ;
  rdfs:label "artificially induced methylation"@en ;
  rdfs:comment "A planned process of adding methyl groups to polymers"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003918 a rdfs:Class ;
  rdfs:label "image segmentation" ;
  rdfs:comment "An image transformation that partitions an image into distinct objects, groups, or regions. Typically represented by spatial coordinates or an image mask of integer values at each pixel or voxel position."@en ;
  rdfs:subClassOf obo:OBI_0003917 .

obo:OBI_0003610 a rdfs:Class ;
  rdfs:label "reactant role"@en ;
  rdfs:comment "A role borne by a biological or chemical entity that participates or has molecular components that participate in a chemical reaction."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:IAO_0000028 a rdfs:Class ;
  rdfs:label "symbol"@en ;
  rdfs:comment "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:IAO_8000007 a rdfs:Class ;
  rdfs:label "curation subset ontology module"@en ;
  rdfs:comment "A subset ontology that is intended as a whitelist for curators using the ontology. Such a subset will exclude classes that curators should not use for curation."@en ;
  rdfs:subClassOf obo:IAO_8000006 .

obo:OBI_0000622 a rdfs:Class ;
  rdfs:label "gel permeation column" ;
  rdfs:comment "A gel permeation column is a chromatography column which is used in gel permeation chromatography and which employs as the stationary phase a swollen gel made by polymerizing and cross-linking styrene in the presence of a diluent which is a nonsolvent for the styrene polymer. The polymer to be analyzed is introduced at the top of the column and then is elutriated with a solvent. The polymer molecules diffuse through the gel at rates depending on their molecular size."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CHEBI_32142 a rdfs:Class ;
  rdfs:label "sodium citrate dihydrate" ;
  rdfs:comment "The dihydrate of trisodium citrate." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0200109 a rdfs:Class ;
  rdfs:label "b transformation"@en ;
  rdfs:comment "A b transformation is a data transformation obtained by applying the function B described in what follows to a (one dimensional) real number input. B(x)= a*exp(b*x)-c*exp(-d*x)+f, where exp denotes an exponential transformation and a, b, c, d, f are real constants with a, b, c, d positive with the objective of normalization."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0200165 a rdfs:Class ;
  rdfs:label "quantile proportion of false positives correction method"@en ;
  rdfs:comment "A quantile proportion of false positives correction method is a multiple testing procedure that controls the pth quantile of the distribution of the proportion of false positives among the rejected hypothesis (false discovery rate)."@en ;
  rdfs:subClassOf obo:OBI_0200089 .

obo:OBI_0002104 a rdfs:Class ;
  rdfs:label "bio-layer interferometry assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A bio-layer interferometry assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001703 , obo:OBI_0002107 .

obo:OBI_0001796 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific IP-10 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects IP-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001308 .

obo:OBI_0002062 a rdfs:Class ;
  rdfs:label "in vitro assay measuring epitope specific T cell killing" ;
  rdfs:comment "An in vitro cell killing assay that measures the killing of antigen presenting cells (APC) by T cells whose TCR recognizes an epitope presented by the APC."@en ;
  rdfs:subClassOf obo:OBI_0000903 , obo:OBI_1110130 .

obo:OBI_1110053 a rdfs:Class ;
  rdfs:label "cancer"@en ;
  rdfs:comment "A disease characterized by abnormal and uncontrolled cell division"@en ;
  rdfs:subClassOf obo:OGMS_0000031 .

obo:CHEBI_59053 a rdfs:Class ;
  rdfs:label "N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide" ;
  rdfs:comment "A carbodiimide having cyclcohexyl and 2-(4-morpholinyl)ethyl as the two <em>N</em>-substituents." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:GO_0010467 a rdfs:Class ;
  rdfs:label "gene expression" ;
  rdfs:comment "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0002147 a rdfs:Class ;
  rdfs:label "HIV group O antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) group O antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0000483 a rdfs:Class ;
  rdfs:label "APOLLO console" ;
  rdfs:comment "The APOLLO is a compact, modular, multiple-DSP, Windows XP Professional-based console that can be equipped with up to 8 DDS-based RF transmitter channels configurable from 2 kHz to 3.5 GHz. Each transmitter channel produces a nominal 1V output and has the most agile frequency, phase and amplitude control of any system on the market. An array of additional options are available including multiple RF transmitters, linear high-power RF amplifiers, digital receiver arrays, low noise figure preamplifiers, a gradient control system, shim unit, MAS spin-speed controller, variable temperature unit, digital lock system and probe/coil interface. With its numerous options, the Apollo can be configured for any NMR, NQR or MRI application."@en ;
  rdfs:subClassOf obo:OBI_0000599 .

obo:OBI_0002356 a rdfs:Class ;
  rdfs:label "performance status value specification" ;
  rdfs:comment "A categorical value specification that is an assessment of a participant's performance status (general well-being and activities of daily life)."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:MRO_0001460 a rdfs:Class ;
  rdfs:label "mouse MHC class I protein complex" ;
  rdfs:subClassOf obo:MRO_0001355 .

obo:OBI_2100333 a rdfs:Class ;
  rdfs:label "manual differential bodily fluid monocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of monocytes in bodily fluid as part of a manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003025 .

obo:OBI_0001497 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific perforin release by T cells" ;
  rdfs:comment "A T cell epitope specific cytotoxic T cell degranulation assay that detects perforin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001269 .

obo:OBI_2100098 a rdfs:Class ;
  rdfs:label "venous blood iron assay" ;
  rdfs:comment "An analyte assay that measures the abundance of iron in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003011 , obo:OBI_0003040 .

obo:BFO_0000040 a rdfs:Class ;
  rdfs:label "material entity"@en ;
  rdfs:comment "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en .

obo:OBI_0400168 a rdfs:Class ;
  rdfs:label "microtome" ;
  rdfs:comment "A microtome is a mechanical instrument used to cut biological specimens into very thin segments for further treatment (e.g. ISH) and ultimately microscopic or histologic examination. Most microtomes provide cooling facilities (cryo-microtome) and use a steel blade to cut a slice of defined thickness. Some are automatic, and some are driven by hand."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0003482 a rdfs:Class ;
  rdfs:label "lymph specimen" ;
  rdfs:comment "A specimen that is derived from a portion of lymph collected from an organism."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0001168 a rdfs:Class ;
  rdfs:label "age since fertilization measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since fertilization, the process of the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0000490 a rdfs:Class ;
  rdfs:label "cation exchange column" ;
  rdfs:comment "A cation exchange column is a chromatography column that is used in cation exchange chromatography."@en ;
  rdfs:subClassOf obo:OBI_0000560 .

obo:OBI_0400120 a rdfs:Class ;
  rdfs:label "temperature control bath" ;
  rdfs:comment "A temperature_control_bath is a device that has the function to regulate the temperature of a material, the function to contain fluid and the function to vary and maintain the temperature of the contained fluid. Heat exchange (energy transfer) between the material and the heating element is facilitated via the contained fluid. A temperature_control_bath is composed of a container, a heating element and/or a cooling element and a means to adjust the needed temperature. In most cases also a timer and a means to stir the fluid is provided as well."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0001504 a rdfs:Class ;
  rdfs:label "dissection"@en ;
  rdfs:comment "A planned process that separates and isolates tissues for surgical purposes, or for the analysis or study of their structures."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001718 a rdfs:Class ;
  rdfs:label "assay measuring the on rate [kon] of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope binding constant determination assay that measures the on rate."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001709 .

obo:OBI_0002569 a rdfs:Class ;
  rdfs:label "trimmed sequence data" ;
  rdfs:comment "The results of a data transformation of sequence data in which (e.g., low quality) read bases are removed, to achieve some specific objective."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001936 a rdfs:Class ;
  rdfs:label "molecular-labeled material" ;
  rdfs:comment "a material entity that is the specified output of an addition of molecular label process that aims to label some molecular target to allow for its detection in a detection of molecular label assay"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:GO_0071608 a rdfs:Class ;
  rdfs:label "macrophage inflammatory protein-1 alpha production" ;
  rdfs:comment "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0003841 a rdfs:Class ;
  rdfs:label "body weight assay at death" ;
  rdfs:comment "A body weight assay with evaluant individual organism specimen with quality dead."@en ;
  rdfs:subClassOf obo:OBI_0003839 .

obo:OBI_0003762 a rdfs:Class ;
  rdfs:label "cell death assay detecting lactate dehydrogenase (LDH) release using absorbance detection." ;
  rdfs:comment "A cell death assay detecting lactate dehydrogenase (LDH) release by absorbance of substrate"@en ;
  rdfs:subClassOf obo:OBI_0003761 .

obo:OBI_0003293 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific perforin release by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects epitope specific perforin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001497 , obo:OBI_0003115 .

obo:OBI_0003311 a rdfs:Class ;
  rdfs:label "DNA split-pool recognition of interactions and tag extension assay" ;
  rdfs:comment "A split-pool recognition of interactions and tag extension (SPRITE) assay that only assays interactions between regions of genomic DNA."@en ;
  rdfs:subClassOf obo:OBI_0003310 .

obo:OBI_0002681 a rdfs:Class ;
  rdfs:label "glass bottle" ;
  rdfs:comment "A container with a narrow neck that is made of glass."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0003129 a rdfs:Class ;
  rdfs:label "chemical mutagenesis" ;
  rdfs:comment "A form of random mutagenesis that produces a mutation by introducing the organism to a chemical mutagen."@en ;
  rdfs:subClassOf obo:OBI_0002620 .

obo:OBI_0000927 a rdfs:Class ;
  rdfs:label "lyophilization storage" ;
  rdfs:comment "a storage process with input material entity and output freeze dried material for long time storage"@en ;
  rdfs:subClassOf obo:OBI_0302893 .

obo:OBI_0600042 a rdfs:Class ;
  rdfs:label "recombinant plasmid cloning"@en ;
  rdfs:comment "the insertion of a particular DNA fragment into a plasmid in order to make copies of a biomaterial"@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_0001848 a rdfs:Class ;
  rdfs:label "chromatin interaction analysis by paired-end tag sequencing assay" ;
  rdfs:comment "An assay that incorporates chromatin immunoprecipitation (ChIP)-based enrichment, chromatin proximity ligation, Paired-End Tags, and high-throughput sequencing to determine de novo long-range chromatin interactions genome-wide."@en ;
  rdfs:subClassOf obo:OBI_0002438 , obo:OBI_0600047 .

obo:OBI_0500027 a rdfs:Class ;
  rdfs:label "inclusion criterion"@en ;
  rdfs:comment "an inclusion criterion (rule) is_a *eligibility criterion*  which defines and states a condition which, if met, makes an entity suitable for a given task or participation in a given process. For instance, in a study protocol, inclusion criteria indicate the conditions that prospective subjects MUST meet to be eligible for participation in a study."@en ;
  rdfs:subClassOf obo:OBI_0500026 .

obo:OBI_0003174 a rdfs:Class ;
  rdfs:label "3,3',5'-triiodothyronine concentration assay" ;
  rdfs:comment "A 3,3',5'-triiodothyronine assay that measures the concentration of 3,3',5'-triiodothyronine in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100046 .

obo:OBI_0001115 a rdfs:Class ;
  rdfs:label "ELISA microplate washer" ;
  rdfs:comment "A microplate washer that is used for enzyme-linked immunosorbent assays (ELISA)."@en ;
  rdfs:subClassOf obo:OBI_0001113 .

obo:OBI_0001852 a rdfs:Class ;
  rdfs:label "paired-end library preparation"@en ;
  rdfs:comment "A library preparation that results in the creation of a library of the 5' and 3' ends of DNA or cDNA fragments using adaptors and endonucleases. The preparation may or may not include cloning process."@en ;
  rdfs:subClassOf obo:OBI_0000711 .

obo:OBI_0400105 a rdfs:Class ;
  rdfs:label "arrayer" ;
  rdfs:comment "A device which deposits biological material onto a substrate in a defined pattern."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_2100077 a rdfs:Class ;
  rdfs:label "CBC venous blood platelet count assay" ;
  rdfs:comment "A cytometry assay that measures the count of platelets in venous blood as part of a CBC order"@en ;
  rdfs:subClassOf obo:OBI_0003028 , obo:OBI_0003040 .

obo:OBI_0000070 a rdfs:Class ;
  rdfs:label "assay"@en ;
  rdfs:comment "A planned process that has the objective to produce information about a material entity (the evaluant) by examining it."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002566 a rdfs:Class ;
  rdfs:label "file merge" ;
  rdfs:comment "A data transformation in which data contained in 2 or more files are merged into a single file."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0200117 a rdfs:Class ;
  rdfs:label "mode calculation"@en ;
  rdfs:comment "A mode calculation is a descriptive statistics calculation in which the mode is calculated which is the most common value in a data set. It is most often used as a measure of center for discrete data."@en ;
  rdfs:subClassOf obo:OBI_0200181 , obo:OBI_0200184 .

obo:PR_000003918 a rdfs:Class ;
  rdfs:label "albumin" ;
  rdfs:comment "A protein that is a translation product of the human ALB gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0000614 a rdfs:Class ;
  rdfs:label "guard column" ;
  rdfs:comment "Guard columns are installed between the injection valve and the analytical or preparative column and here will remove contaminants and prolong the lifetime of the columns."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_2100349 a rdfs:Class ;
  rdfs:label "direct venous blood bilirubin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin in venous blood as part of a direct order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100018 .

obo:OBI_0002981 a rdfs:Class ;
  rdfs:label "reference gene sequence start site" ;
  rdfs:comment "The position of the first nucleotide in a reference gene sequence (sequence being used for comparison)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0000988 a rdfs:Class ;
  rdfs:label "obsolete performing a diagnosis" ;
  rdfs:comment "The interpretation of the information available about bodily features (clinical picture) of a patient resulting in a diagnosis"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001384 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interleukin-3 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001406 .

obo:OBI_0000875 a rdfs:Class ;
  rdfs:label "viral hemagglutination inhibition assay" ;
  rdfs:comment "An assay that measures the ability of an evaluant to inhibit hemagglutination by a virus. Hemagglutinin is a viral protein which binds to sialic acid receptors on cells or to erythrocytes, causing the cells to clump. Loss of clumping indicates that the evaluant blocks binding of hemagglutinin to sialic acid receptors."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:PATO_0001394 a rdfs:Class ;
  rdfs:label "diploid" ;
  rdfs:comment "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." ;
  rdfs:subClassOf obo:PATO_0001393 .

obo:OBI_2100209 a rdfs:Class ;
  rdfs:label "SPEP protein electrophoresis venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a SPEP protein electrophoresis order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_0000275 a rdfs:Class ;
  rdfs:label "analyte role"@en ;
  rdfs:comment "A measurand role borne by a molecular entity or an atom and realized in an analyte assay which achieves the objective to measure the magnitude/concentration/amount of the analyte in the entity bearing evaluant role."@en ;
  rdfs:subClassOf obo:OBI_0002444 .

obo:RO_0000081 a rdf:Property ;
  rdfs:label "role of"@en ;
  rdfs:comment "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_2100400 a rdfs:Class ;
  rdfs:label "lipid panel reflex direct venous blood cholesterol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of cholesterol in venous blood as part of a Lipid panel reflex direct order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100031 .

obo:OBI_0003386 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 1500" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation, with a single flow cell. Built upon sequencing by synthesis technology, the machine employs dual surface imaging and offers two high-output options and one rapid-run option."@en ;
  rdfs:subClassOf obo:OBI_0003683 .

obo:SO_0000149 a rdfs:Class ;
  rdfs:label "contig" ;
  rdfs:comment "A contiguous sequence derived from sequence assembly. Has no gaps, but may contain N's from unavailable bases." ;
  rdfs:subClassOf obo:SO_0000353 .

obo:COB_0000110 a rdfs:Class ;
  rdfs:label "material processing"@en ;
  rdfs:comment "A completely executed planned process that intends to output material entities from input material entities"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001960 a rdfs:Class ;
  rdfs:label "taxonomic diversity assessment by targeted gene survey" ;
  rdfs:comment "An assay that dteremines taxonomic and community diversity information by sequencing specific genomic regions used as marker of identity or diversity."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_0001464 a rdfs:Class ;
  rdfs:label "strain comparison design" ;
  rdfs:comment "A study design that assays differences between multiple strains, cultivars, serovars, isolates, lines from organisms of a single species."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003203 a rdfs:Class ;
  rdfs:label "leptin concentration assay" ;
  rdfs:comment "An leptin assay that measures the concentration of leptin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003202 .

obo:OBI_0002732 a rdfs:Class ;
  rdfs:label "blood meal assay" ;
  rdfs:comment "An assay that analyzes the specimen taken from blood meal fed organism, such as insect."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001863 a rdfs:Class ;
  rdfs:label "shotgun bisulfite-seq assay" ;
  rdfs:comment "A bisulfite sequencing assay that identifies methylated cytosines across the genome using high throughput sequencing."@en ;
  rdfs:subClassOf obo:OBI_0000748 .

obo:OBI_0003885 a rdfs:Class ;
  rdfs:label "1M7 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 1-methyl-7-nitroisatoic anhydride as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0003412 a rdfs:Class ;
  rdfs:label "linked-read sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that uses microfluidics to partition and barcode high molecular weight DNA such that short reads derived from fragments of the large piece of DNA can be assembled within the context of the high molecular weight piece of DNA they are derived from, facilitating the use of short read data to sequence and assemble large genomes."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_2100294 a rdfs:Class ;
  rdfs:label "venous blood T4 assay" ;
  rdfs:comment "An analyte assay that measures the abundance of T4 in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100035 .

obo:OBI_0002464 a rdfs:Class ;
  rdfs:label "SRS identifier"@en ;
  rdfs:comment "An accession number that applies to a database record for an individual sample object in an NCBI Sequence Read Archive (SRA) submission. These records are imported from the NCBI BioSample database."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0001838 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001280 , obo:OBI_0600031 .

obo:OBI_2100175 a rdfs:Class ;
  rdfs:label "non-vented blood gas arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a non-vented blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0002411 a rdfs:Class ;
  rdfs:label "indeterminate menopausal status" ;
  rdfs:comment "A menopausal status that is neither pre- nor post-menopausal."@en ;
  rdfs:subClassOf obo:OBI_0002410 .

obo:PATO_0000033 a rdfs:Class ;
  rdfs:label "concentration of" ;
  rdfs:comment "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." ;
  rdfs:subClassOf obo:PATO_0000070 .

obo:OBI_0001040 a rdfs:Class ;
  rdfs:label "current amplification function" ;
  rdfs:comment "A current amplification function is an amplification function that increases the amplitude of a current."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0001555 a rdfs:Class ;
  rdfs:label "assay measuring binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A qualitative binding assay that detects the binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002072 .

obo:OBI_0003751 a rdfs:Class ;
  rdfs:label "neuronal differentiation assay" ;
  rdfs:comment "A cell differentiation assay that measures differentiation of neurons."@en ;
  rdfs:subClassOf obo:OBI_0003720 .

obo:OBI_0400116 a rdfs:Class ;
  rdfs:label "thermal cycler" ;
  rdfs:comment "An instrument that is capable of repeatedly altering and maintaining specific temperatures for defined periods of time."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0003423 a rdfs:Class ;
  rdfs:label "5'-nucleotidase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of 5'-nucleotidase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:CHEBI_59056 a rdfs:Class ;
  rdfs:label "EDTA methidiumpropylamide" ;
  rdfs:comment "A combined intercalating and chelating reagent. The iron chelate, prepared by adding Fe(NH4)2(SO4)2, effects random oxidative cleavage of DNA in the presence of O2 and a reducing agent. This activity is useful as a footprinting probe." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2000000 a rdfs:Class ;
  rdfs:label "uterine cervix specimen" ;
  rdfs:comment "A specimen that is derived from some uterine cervix"@en ;
  rdfs:subClassOf obo:OBI_0002553 .

obo:OBI_0003480 a rdfs:Class ;
  rdfs:label "Gram stain assay" ;
  rdfs:comment "An organism detection assay that identifies bacteria based on the differential retention of a crystal violet-iodine complex within the cell wall."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:NCBITaxon_10090 a rdfs:Class ;
  rdfs:label "Mus musculus" ;
  rdfs:subClassOf obo:NCBITaxon_39107 .

obo:OBI_0002067 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific macrophage migration inhibitory factor (MIF) production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects macrophage migration inhibitory factor (MIF) production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0002057 , obo:OBI_0003115 .

obo:OBI_0001734 a rdfs:Class ;
  rdfs:label "calorimetry assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A calorimetric binding assay that measures the dissociation constant [KD] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001634 , obo:OBI_0001708 .

obo:OBI_0001598 a rdfs:Class ;
  rdfs:label "data maintenance service" ;
  rdfs:comment "A maintenance service in which a service provider actively manages or maintains data or a database for the service consumer.  Maintenance of the data is performed to maintain its integrity or enhance its quality or utility for the consumer, but new data is not generated as a result of the maintenance."@en ;
  rdfs:subClassOf obo:OBI_0001530 .

obo:OBI_0001719 a rdfs:Class ;
  rdfs:label "assay measuring the association constant [KA] of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope binding constant determination assay that measures the association constant KA."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001709 .

obo:OBI_0003295 a rdfs:Class ;
  rdfs:label "positive binding datum" ;
  rdfs:comment "A categorical binding datum that states that there is a significant disposition of two or more entities to form a complex."@en ;
  rdfs:subClassOf obo:OBI_0003141 .

obo:OBI_0000973 a rdfs:Class ;
  rdfs:label "sequence data"@en ;
  rdfs:comment "A data item that representing the primary structure of a macromolecule(it's sequence) sometimes associated with an indicator of confidence of that measurement."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_1110132 a rdfs:Class ;
  rdfs:label "obsolete CD8 receptor" ;
  rdfs:comment "A transmembrane glycoprotein that serves as a co-receptor for the T cell receptor."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003348 a rdfs:Class ;
  rdfs:label "T2 weighted magnetic resonance image data set" ;
  rdfs:comment "A magnetic resonance image produced by a T2 weighted magnetic resonance image acquisition sequence."@en ;
  rdfs:subClassOf obo:OBI_0003334 .

obo:UBERON_0001873 a rdfs:Class ;
  rdfs:label "caudate nucleus" ;
  rdfs:comment "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0200020 a rdfs:Class ;
  rdfs:label "homogeneous polynomial transformation"@en ;
  rdfs:comment "A homogeneous polynomial transformation is a polynomial transformation where all the term of the polynomial have the same degree."@en ;
  rdfs:subClassOf obo:OBI_0200093 .

obo:OBI_0000932 a rdfs:Class ;
  rdfs:label "material separation device" ;
  rdfs:comment "A device with a separation function realized in a planed process"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003231 a rdfs:Class ;
  rdfs:label "leukapheresis" ;
  rdfs:comment "A blood specimen collection in which white blood cells are separated from a blood specimen."@en ;
  rdfs:subClassOf obo:OBI_1110095 .

obo:OBI_0000527 a rdfs:Class ;
  rdfs:label "flow high resolution probe" ;
  rdfs:comment "Hyphenated analytical techniques combining mass spectrometry and chromatography are well-established laboratory tools. The combination of chromatography and NMR has also made its way into the analytical laboratory. Further developments even combine all three techniques into an LC-NMR/NMR-MS system. The use of solid phase extraction provides an efficient interface between chromatography and NMR with demands for special type of flow probes."@en ;
  rdfs:subClassOf obo:OBI_0000480 .

obo:UBERON_0002813 a rdfs:Class ;
  rdfs:label "right cerebral hemisphere" ;
  rdfs:comment "A cerebral hemisphere that is in the right side of a brain." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003924 a rdfs:Class ;
  rdfs:label "metagenome binning" ;
  rdfs:comment "A data transformation that partitions metagenomic sequence data into groups (bins), each representing the putative genome of a single organism or population present in a metagenome."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:IAO_0000577 a rdfs:Class ;
  rdfs:label "centrally registered identifier symbol"@en ;
  rdfs:comment "A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry."@en ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:OBI_0001394 a rdfs:Class ;
  rdfs:label "epitope specific cytotoxic T cell degranulation" ;
  rdfs:comment "A process of cytotoxic T cell degranulation resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0043316 .

obo:OBI_0001095 a rdfs:Class ;
  rdfs:label "coagulation analyzer" ;
  rdfs:comment "A device for automatically analyzing blood coagulation in a clinical laboratory."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001222 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific RANTES production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects RANTES production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001232 .

obo:OBI_0003318 a rdfs:Class ;
  rdfs:label "granzyme A release during T cell degranulation" ;
  rdfs:comment "The release of granzyme A during cytotoxic T cell degranulation."@en ;
  rdfs:subClassOf obo:GO_0035746 .

obo:UBERON_0000978 a rdfs:Class ;
  rdfs:label "leg" ;
  rdfs:comment "The portion of the hindlimb that contains both the stylopod and zeugopod." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001897 a rdfs:Class ;
  rdfs:label "organization of sequencing facility contact person"@en ;
  rdfs:comment "An organization that is the affiliation of the contact representative at the sequencing facility"@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:MRO_0000966 a rdfs:Class ;
  rdfs:label "H2-Db protein complex" ;
  rdfs:subClassOf obo:MRO_0001759 .

obo:OBI_0000803 a rdfs:Class ;
  rdfs:label "denaturing" ;
  rdfs:comment "Is a process in which the tertiary or secondary structure of a polymer is disrupted"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0600043 a rdfs:Class ;
  rdfs:label "genetic transformation"@en ;
  rdfs:comment "the introduction. alteration or integration of genetic material into a cell or organism"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000632 a rdfs:Class ;
  rdfs:label "Bruker Metabolic Profiler" ;
  rdfs:comment "An NMR platform for conducting metabonomics studies, traditional metabolism studies, and analysis of complex mixtures, featuring an Avance NMR spectrometer and a microTOF from Bruker Daltonics. By combining the structural resolving power of NMR with mass accuracy of the microTOF Bruker offers a complete system for metabolic research. The Metabolic Profiler provides a simple, easy to use and inexpensive base-system to acquire the spectroscopic data, needed to do basic metabolic profiling including metabonomic statistical analysis."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:UBERON_0002409 a rdfs:Class ;
  rdfs:label "pericardial fluid" ;
  rdfs:comment "Transudate contained in the pericardial cavity.[FMA]." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0400016 a rdfs:Class ;
  rdfs:label "BioSorter250" ;
  rdfs:comment "A BioSorter250 is a flow_cytometer_sorter manufactured by Union Biometrica. It includes analog electronics, 488/514 nm multi-line Argon-ion laser for fluorescence and a light stabilized 670 nm forward scatter laser for extinction and time-of-flight. It has filters and PMTs for 3 fluorescent parameters and photodiodes for scatter, time of flight, and extinction. The flow cell is quartz cuvette. The BioSorterTM 250 is an instrument for analyzing and sorting objects from 40-200 microns in diameter."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_2100306 a rdfs:Class ;
  rdfs:label "CBC with automated differential venous blood nucleated RBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of nucleated RBCs in venous blood as part of a CBC with automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:GO_0071735 a rdfs:Class ;
  rdfs:label "IgG immunoglobulin complex" ;
  rdfs:comment "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ;
  rdfs:subClassOf obo:GO_0019814 .

obo:OBI_0003397 a rdfs:Class ;
  rdfs:label "Affymetrix Human Genome U219 Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, which comprises more than 530,000 probes covering more than 36,000 transcripts and variants, which represent more than 20,000 genes mapped through RefSeq or via UniGene annotation. Sequences used in the design of the array were selected from the RefSeq version 36, UniGene database 219, and full-length human mRNAs from GenBank™."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0302890 a rdfs:Class ;
  rdfs:label "polymerization"@en ;
  rdfs:comment "polymerization is process by which molecular entity of small mass are aggregated in motifs over the course of a chemical reaction catalyzed by enzymes or other molecular entities acting as catalyst. polymerization results in molecular entity of high molecular weight"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003798 a rdfs:Class ;
  rdfs:label "viral plaque assay" ;
  rdfs:comment "An analyte assay measuring the number of discrete viral plaques."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0500006 a rdfs:Class ;
  rdfs:label "parallel group design" ;
  rdfs:comment "A parallel group design or independent measure design is a study design which uses unique experimental unit each experimental group, in other word no two individuals are shared between experimental groups, hence also known as parallel group design. Subjects of a treatment group receive a unique combination of independent variable values making up a treatment"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001025 a rdfs:Class ;
  rdfs:label "binding constant determination assay" ;
  rdfs:comment "A binding assay where the specified output is a binding constant"@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0000538 a rdfs:Class ;
  rdfs:label "in-line filter" ;
  rdfs:comment "A solvent filter that sits between the pump and the injection valve that prevents dust particles, general debris and, to some extent, bacteria from entering the chromatography system. Contaminants can interfere with the low-pressure gradient former or the pump and particles entering valves may interfere with the proper function. The result could cause an increased baseline noise, non-repeatable gradient forming, unreliable flow rate or other interferences. Solvent in-line filters are low-pressure filters and will allow a high flow rate due to a large surface area and large porosity."@en ;
  rdfs:subClassOf obo:OBI_0000592 .

obo:CHEBI_2637 a rdfs:Class ;
  rdfs:label "amikacin" ;
  rdfs:comment "An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_1110195 a rdfs:Class ;
  rdfs:label "epitope specific IL-18 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-18 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032621 , obo:OBI_0001193 .

obo:OBI_0001080 a rdfs:Class ;
  rdfs:label "patch clamp device" ;
  rdfs:comment "A device used in electrophysiology that allows the study of single or multiple ion channels in cells."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:GO_0016231 a rdfs:Class ;
  rdfs:label "beta-N-acetylglucosaminidase activity" ;
  rdfs:comment "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0001561 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring half maximal effective concentration [EC50] to determine direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures half maximal effective concentration (EC50) to detect direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001991 .

obo:OBI_0003262 a rdfs:Class ;
  rdfs:label "virus in blood datum" ;
  rdfs:comment "A blood microbiology datum that is about a virus."@en ;
  rdfs:subClassOf obo:OBI_0003244 .

obo:OBI_2100384 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood plasma cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of plasma cells in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003024 , obo:OBI_0003040 .

obo:OBI_0003808 a rdfs:Class ;
  rdfs:label "multi-electrode array plate" ;
  rdfs:comment "A measurement device consisting of grid of tightly spaced microscopic electrodes that can detect the electrical signals of cells in close proximity."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001465 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects monocyte chemotactic protein-1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0200184 a rdfs:Class ;
  rdfs:label "descriptive statistical calculation data transformation"@en ;
  rdfs:comment "A descriptive statistical calculation data transformation is a data transformation that has objective descriptive statistical calculation and which concerns any calculation intended to describe a feature of a data set, for example, its center or its variability."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0002060 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 17 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-C motif) ligand 17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0002056 .

obo:OBI_0003123 a rdfs:Class ;
  rdfs:label "3D neural cell structure determination assay" ;
  rdfs:comment "A 3D cell structure determination assay that determines the 3-dimensional configuration of a neural cell."@en ;
  rdfs:subClassOf obo:OBI_0003122 .

obo:PR_000007141 a rdfs:Class ;
  rdfs:label "erythropoietin" ;
  rdfs:comment "A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:NCBITaxon_10376 a rdfs:Class ;
  rdfs:label "human gammaherpesvirus 4" ;
  rdfs:subClassOf obo:NCBITaxon_3044472 .

obo:OBI_0001014 a rdfs:Class ;
  rdfs:label "single-nucleotide-resolution nucleic acid structure mapping assay using enzymatic probing" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines structural information about the RNA species under study using proteins acting as enzymatic probes."@en ;
  rdfs:subClassOf obo:OBI_0000870 .

obo:PR_000003745 a rdfs:Class ;
  rdfs:label "double-stranded RNA-specific adenosine deaminase" ;
  rdfs:comment "A protein that is a translation product of the human ADAR gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_2100331 a rdfs:Class ;
  rdfs:label "manual differential bodily fluid segmented neutrophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of segmented neutrophils in bodily fluid as part of a manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003022 .

obo:OBI_0001254 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "A process of interleukin-3 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032632 , obo:OBI_0001193 .

obo:OBI_0002519 a rdfs:Class ;
  rdfs:label "skeletal muscle tissue specimen" ;
  rdfs:comment "A specimen that is derived from skeletal muscle."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0003029 a rdfs:Class ;
  rdfs:label "barcode target locus role" ;
  rdfs:comment "An evaluant role that is realized in a taxonomic diversity assessment by targeted gene survey involving sequencing a small defined region of genome amplified by PCR."@en ;
  rdfs:subClassOf obo:OBI_0000067 .

obo:OBI_0002013 a rdfs:Class ;
  rdfs:label "nCounter Human miRNA Expression array" ;
  rdfs:comment "A human array which is manufacutred by NanoString Technologies. Built upon color-coded molecular barcodes technology, the array profiles miRNA with increased specificity and sensitivty than microarrays."@en ;
  rdfs:subClassOf obo:OBI_0001865 .

obo:OBI_0001684 a rdfs:Class ;
  rdfs:label "methylation-specific polymerase chain reaction assay" ;
  rdfs:comment "An assay that uses initial modification of DNA by sodium bisulfite, converting all unmethylated, but not methylated, cytosines to uracil, and subsequent amplification with primers specific for methylated versus unmethylated DNA."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002793 a rdfs:Class ;
  rdfs:label "scrubs" ;
  rdfs:comment "A personal protective clothing item which is sterilized and which is worn by a health care professional.  It can reference a shirt and pants or dress, and depending on medical protocol, may include a medical cap."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_0000882 a rdfs:Class ;
  rdfs:label "cell-cell killing assay" ;
  rdfs:comment "A cytometry assay that monitors a cell population to track how many are killed by other cells."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002038 a rdfs:Class ;
  rdfs:label "ribosomal profiling by sequencing assay" ;
  rdfs:comment "A translation profiling assay that sequences only mRNA protected by the ribosome during translation and thus provides information on which transcipts are undergoing active translation."@en ;
  rdfs:subClassOf obo:OBI_0001282 .

obo:OBI_0003740 a rdfs:Class ;
  rdfs:label "childhood myositis assessment scale score"@en ;
  rdfs:comment "A clinical data item that quantifies the degree of muscle function in a child with myositis based on performance of 14 tasks associated with muscular strength and endurance."@en ;
  rdfs:subClassOf obo:OGMS_0000123 .

obo:OBI_2100088 a rdfs:Class ;
  rdfs:label "basic metabolic panel venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a basic metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0000669 a rdfs:Class ;
  rdfs:label "tritiated thymidine incorporation assay" ;
  rdfs:comment "A cell proliferation assay in which cells are cultured in the presence of tritiated thymidine which is incorporated into newly synthesized DNA of replicating cells (during the S phase of the cell cycle). The radioactivity of tritiated thymidine in a cell is a proxy for cells that were actively replicating."@en ;
  rdfs:subClassOf obo:OBI_0000891 .

obo:OBI_0003343 a rdfs:Class ;
  rdfs:label "T1 weighted GRE magnetic resonance image data set" ;
  rdfs:comment "T1 weighted image data set collected using a gradient recall echo sequence."@en ;
  rdfs:subClassOf obo:OBI_0003341 .

obo:OBI_0000859 a rdfs:Class ;
  rdfs:label "cytoplasmic RNA extraction" ;
  rdfs:comment "A RNA extraction process in which the desired output material is RNA in the cytoplasm."@en ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBI_0400066 a rdfs:Class ;
  rdfs:label "logarithmic voltage amplifier" ;
  rdfs:comment "A logarithmic voltage amplifier is an analog electronic circuit that puts out a voltage or current proportional to the voltage or current at its input, with logarithmic proportionality. In an analog system, the logarithmic voltage amplifier is used to present parameters with a high dynamic range on a more useful scale."@en ;
  rdfs:subClassOf obo:OBI_0400101 .

obo:OBI_2100391 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid segmented neutrophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of segmented neutrophils in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003022 , obo:OBI_0003232 .

obo:OBI_0001313 a rdfs:Class ;
  rdfs:label "transcription profiling by RT-PCR design" ;
  rdfs:comment "A study design which aims to examine the transcriptome of a biological sample by reverse transcription PCR (RT-PCR)."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001990 a rdfs:Class ;
  rdfs:label "assay measuring the half life of a MHC:ligand complex" ;
  rdfs:comment "A MHC binding constant determination assay measuring half life of binding."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001553 .

obo:OBI_0000621 a rdfs:Class ;
  rdfs:label "custom made column" ;
  rdfs:comment "A custom made column ia a chromatography column which is specifically tailored according to the needs of the separation as requested by a scientist or working group."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_1110036 a rdfs:Class ;
  rdfs:label "JY cell line"@en ;
  rdfs:comment "The JY cell line is an Epstein-Barr virus (EBV)-immortalised b cell lymphoblastoid line.(wikipedia)"@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0003557 a rdfs:Class ;
  rdfs:label "cervical administration" ;
  rdfs:comment "An administration of a substance to the cervix of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0002675 a rdfs:Class ;
  rdfs:label "massively parallel reporter assay" ;
  rdfs:comment "An assay in which multiplexing the construction and interrogation of larger libraries of reporter constructs allows measurement of the transcriptional regulatory activities of thousands to hundreds of thousands of DNA sequences."@en ;
  rdfs:subClassOf obo:OBI_0002082 .

obo:OBI_0002702 a rdfs:Class ;
  rdfs:label "insecticide resistance by detecting glutathione S-transferase activity assay" ;
  rdfs:comment "An insecticide resistance by detecting enzyme activity assay that measures activity of glutathione S-transferase (GST)."@en ;
  rdfs:subClassOf obo:OBI_0002697 .

obo:OBI_0001506 a rdfs:Class ;
  rdfs:label "specimen with pre- or post-mortem status" ;
  rdfs:comment "A specimen that has been established to be taken from a live (pre-mortem) or dead (post-mortem) organism."@en ;
  rdfs:subClassOf obo:OBI_0001479 , obo:OBI_0100051 .

obo:OBI_2100048 a rdfs:Class ;
  rdfs:label "megakaryocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of megakaryocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0001131 a rdfs:Class ;
  rdfs:label "slide warmer" ;
  rdfs:comment "A device that is used to heat microscope slides."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_0002556 a rdfs:Class ;
  rdfs:label "minimum age value specification"@en ;
  rdfs:comment "A value specifcation that specifies the youngest age when specifying an age range."@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:CHEBI_39867 a rdfs:Class ;
  rdfs:label "valproic acid" ;
  rdfs:comment "A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem." ;
  rdfs:subClassOf obo:CHEBI_35366 .

obo:OBI_2100301 a rdfs:Class ;
  rdfs:label "bone profile venous blood protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in venous blood as part of a bone profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0001227 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-6 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-6 production by T cells"@en ;
  rdfs:subClassOf obo:OBI_0001451 , obo:OBI_0600031 .

obo:OBI_0003717 a rdfs:Class ;
  rdfs:label "heart rate variability assay" ;
  rdfs:comment "A pulse rate assay that measures beat to beat variability in heart beats."@en ;
  rdfs:subClassOf obo:OBI_0003718 .

obo:PR_000006592 a rdfs:Class ;
  rdfs:label "deoxyribonuclease-1" ;
  rdfs:comment "A protein that is a translation product of the human DNASE1 gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0001001 a rdfs:Class ;
  rdfs:label "Edinburgh handedness assay" ;
  rdfs:comment "An assay that uses a set of questions (the Edinburgh Handedness inventory) to generate a score that can be used to assess the dominance of a person's right or left hand in everyday activities. The inventory can be used by an observer assessing the person, or by a person self-reporting hand use. The latter method tends to be less reliable due to a person over-attributing tasks to the dominant hand."@en ;
  rdfs:subClassOf obo:OBI_0000944 .

obo:OBI_0001174 a rdfs:Class ;
  rdfs:label "passive immunization" ;
  rdfs:comment "The injection of immune effector material (antibodies, T cells or B cells) into an organism so that the organisms immune system gains its  immune effector function to recognize specific antigens."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_1110126 a rdfs:Class ;
  rdfs:label "assay measuring binding of a MHC:ligand complex" ;
  rdfs:comment "A MHC ligand assay that detects the binding of a ligand to an MHC molecule."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002075 .

obo:OBI_0003608 a rdfs:Class ;
  rdfs:label "disease severity reduction objective"@en ;
  rdfs:comment "An objective specification that is fulfilled by reducing the severity of a disease in a particular organism."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0002024 a rdfs:Class ;
  rdfs:label "SOLiD 4 System" ;
  rdfs:comment "An AB SOLid System which is manufacted by the Applied Biosystems corporation. Built upon SOLiD sequencing technology, the machine generates greater than 1 billion mappable reads per run."@en ;
  rdfs:subClassOf obo:OBI_0000696 .

obo:CHEBI_16301 a rdfs:Class ;
  rdfs:label "nitrite" ;
  rdfs:comment "The nitrogen oxoanion formed by loss of a proton from nitrous acid." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003584 a rdfs:Class ;
  rdfs:label "cell viability assay using Annexin V staining" ;
  rdfs:comment "A cell viability assay that uses Annexin V staining to detect apoptotic cells."@en ;
  rdfs:subClassOf obo:OBI_0003583 .

obo:HP_0000855 a rdfs:Class ;
  rdfs:label "Insulin resistance" ;
  rdfs:comment "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_2100003 a rdfs:Class ;
  rdfs:label "creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0200080 a rdfs:Class ;
  rdfs:label "network analysis"@en ;
  rdfs:comment "A data transformation that takes as input data that describes biological networks in terms of the node (a.k.a. vertex) and edge graph elements and their characteristics and generates as output properties of the constituent nodes and edges, the sub-graphs, and the entire network."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0003134 a rdfs:Class ;
  rdfs:label "TALEN mediated mutagenesis" ;
  rdfs:comment "An endonuclease mediated mutagenesis in which guide RNAs and transcription activator-like effector nucleases (TALENs) are used to introduce a mutation at a specific location in the genome."@en ;
  rdfs:subClassOf obo:OBI_0003132 .

obo:OBI_0002422 a rdfs:Class ;
  rdfs:label "indicator of whether all inclusion criteria were met" ;
  rdfs:comment "An information content entity  that indicates whether or not  an entity  has met all specific requirements in order to take part in a given process."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003082 a rdfs:Class ;
  rdfs:label "extraction duration time" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration of an extraction process."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0002728 a rdfs:Class ;
  rdfs:label "pathogen detection assay" ;
  rdfs:comment "An organism detection assay that detects pathogens."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0000084 a rdfs:Class ;
  rdfs:label "polystyrene tube" ;
  rdfs:comment "A polystyrene tube is a test tube made of polystyrene"@en ;
  rdfs:subClassOf obo:OBI_0000836 .

obo:OBI_0002743 a rdfs:Class ;
  rdfs:label "molecular label role"@en ;
  rdfs:comment "A reagent role inhering in a molecular entity intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay."@en ;
  rdfs:subClassOf obo:OBI_0000086 .

obo:OBI_0001934 a rdfs:Class ;
  rdfs:label "predicted value" ;
  rdfs:comment "an information content entity that has been generated by a prediction process in which an estimate of a value of an entity is made which can be measured but without performing such a measurement. The value specification is intended to be close to the value a measurement process would produce modulo a prediction error."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0002649 a rdfs:Class ;
  rdfs:label "blood microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a blood specimen."@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_0003498 .

obo:OBI_2100237 a rdfs:Class ;
  rdfs:label "chem16 venous blood magnesium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of magnesium in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100021 .

obo:UBERON_0001225 a rdfs:Class ;
  rdfs:label "cortex of kidney" ;
  rdfs:comment "Outer cortical portion of the kidney, between the renal capsule and the renal medulla." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_2100316 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0002638 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from challenge resulting from adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that uses a epitope protection experiment after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0001710 , obo:OBI_0002677 .

obo:OBI_0000796 a rdfs:Class ;
  rdfs:label "purification objective" ;
  rdfs:comment "The objective to separate a material entity into different compositions of which one or more have are purified fractions that contain higher concentration of a desired component, while others contain impurities and are not of interest"@en ;
  rdfs:subClassOf obo:OBI_0000681 .

obo:OBI_0100086 a rdfs:Class ;
  rdfs:label "glucose in solution" ;
  rdfs:comment "A scattered aggregate of glucose molecules in a liquid"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003419 a rdfs:Class ;
  rdfs:label "antigen specific antibodies in milk assay" ;
  rdfs:comment "An antigen specific antibodies assay that has a milk specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0002145 , obo:OBI_0003236 .

obo:NCBITaxon_11709 a rdfs:Class ;
  rdfs:label "Human immunodeficiency virus 2" ;
  rdfs:subClassOf obo:NCBITaxon_11646 .

obo:OBI_0001196 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific IP-10 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects IP-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001308 , obo:OBI_0003115 .

obo:OBI_0000747 a rdfs:Class ;
  rdfs:label "material sample" ;
  rdfs:comment "A material entity that has the material sample role"@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0000356 a rdfs:Class ;
  rdfs:label "hypothesis generating investigation"@en ;
  rdfs:comment "is an investigation in which data is generated and analyzed with the purpose of generating new hypothesis"@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_0003899 a rdfs:Class ;
  rdfs:label "electrocardiogram assay" ;
  rdfs:comment "An electrophysiology assay that measures heart activity using electrodes placed to detect electrical signals from the heart."@en ;
  rdfs:subClassOf obo:OBI_0002176 .

obo:OBI_0002908 a rdfs:Class ;
  rdfs:label "arthropod resting in animal house specimen collection by aspiration" ;
  rdfs:comment "An arthropod specimen collection by aspiration that catches specimens resting inside an animal house."@en ;
  rdfs:subClassOf obo:OBI_0002912 .

obo:OBI_0302911 a rdfs:Class ;
  rdfs:label "validation"@en ;
  rdfs:comment "a planned process with objective to check that the accuracy or the quality of a claim or prediction  satisfies some criteria and which is assessed by comparing with independent results"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003498 a rdfs:Class ;
  rdfs:label "organism detection assay" ;
  rdfs:comment "An assay that detects a type of organism and/or the quantity of individuals of a type of organism."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001550 a rdfs:Class ;
  rdfs:label "assay measuring binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A qualitative binding assay that detects the binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002072 .

obo:OBI_0001200 a rdfs:Class ;
  rdfs:label "genotyping by high throughput sequencing design" ;
  rdfs:comment "A study design that classifies an individual or group of individuals on the basis of alleles, haplotypes, SNPs using high througput sequencing techniques."@en ;
  rdfs:subClassOf obo:OBI_0001444 .

obo:OBI_0001469 a rdfs:Class ;
  rdfs:label "monospecific T cell recognition assay measuring MHC ligand processing and presentation" ;
  rdfs:comment "A MHC ligand processing and presentation assay in which the presence of a specific ligand in an eluate is detected using the response of T cells that are known to be monospecific for that ligand as a readout."@en ;
  rdfs:subClassOf obo:OBI_1110125 .

obo:OBI_0000910 a rdfs:Class ;
  rdfs:label "radio immuno assay" ;
  rdfs:comment "An assay in which a radioactive labeled antigen or antibody is used to determine the interaction between an antigen and its receptor. This can be used to detect the presence of an antigen of interest in an input sample or determine the specificity of an input antibody."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_1110094 a rdfs:Class ;
  rdfs:label "immunization"@en ;
  rdfs:comment "The process of an epitope that is part of or derived from an immunogen coming into contact with adaptive immune cells resulting in these cells acquiring immune effector functions specific for the epitope."@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:UBERON_0013756 a rdfs:Class ;
  rdfs:label "venous blood" ;
  rdfs:comment "A blood that is part of a vein." ;
  rdfs:subClassOf obo:UBERON_0000178 .

obo:OBI_0003284 a rdfs:Class ;
  rdfs:label "umbilical cord blood microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in an umbilical cord blood specimen."@en ;
  rdfs:subClassOf obo:OBI_0002649 , obo:OBI_0003238 .

obo:OBI_0001070 a rdfs:Class ;
  rdfs:label "scintillation counter" ;
  rdfs:comment "A device that is used to measure ionizing radiation."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_1110109 a rdfs:Class ;
  rdfs:label "target of material addition" ;
  rdfs:comment "A material entity that receives the addition of another material entity in an “adding a material entity into a target” process."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003535 a rdfs:Class ;
  rdfs:label "deep tendon reflex assessment of the knee joint" ;
  rdfs:comment "A deep tendon reflex assessment of an individual's reaction to stimulus applied to a knee joint."@en ;
  rdfs:subClassOf obo:OBI_0003517 .

obo:OBI_0001615 a rdfs:Class ;
  rdfs:label "investigation description"@en ;
  rdfs:comment "A textual entity that describes an investigation."@en ;
  rdfs:subClassOf obo:OBI_0001898 .

obo:OBI_0200054 a rdfs:Class ;
  rdfs:label "global modularity calculation"@en ;
  rdfs:comment "A network graph quality calculation in which an input data set of subgraph modules and their in-degree and out-degree qualities is used to calculate the average modularity of subgraphs within the network."@en ;
  rdfs:subClassOf obo:OBI_0200147 .

obo:OBI_0002589 a rdfs:Class ;
  rdfs:label "unsupervised machine learning" ;
  rdfs:comment "A machine learning process that infers a function describing the structure of \"unlabeled\" data (i.e. data that has not been classified or categorized)."@en ;
  rdfs:subClassOf obo:OBI_0002587 .

obo:OBI_2100353 a rdfs:Class ;
  rdfs:label "hemoglobin and hematocrit venous blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a hemoglobin and hematocrit order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0200031 a rdfs:Class ;
  rdfs:label "differential expression analysis objective"@en ;
  rdfs:comment "A differential expression analysis objective is a data transformation objective whose input consists of expression levels of entities (such as transcripts or proteins), or of sets of such expression levels, under two or more conditions and whose output reflects which of these are likely to have different expression across such conditions."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0000000 a rdfs:Class ;
  rdfs:label "cell" ;
  rdfs:comment "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_0000188 a rdfs:Class ;
  rdfs:label "role of pathology review board"@en ;
  rdfs:comment "a worker role comprised of providing a confirmed and consensus diagnosis for histopathology results obtained during the investigation"@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:OBI_0002695 a rdfs:Class ;
  rdfs:label "insecticide resistance assay" ;
  rdfs:comment "An assay that aims to detect the presence and/or frequency of resistance to insecticides in an organism or organism population."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003592 a rdfs:Class ;
  rdfs:label "sequential organ failure assessment score"@en ;
  rdfs:comment "A clinical data item that quantifies the degree of function of a critically ill patient's organs."@en ;
  rdfs:subClassOf obo:OGMS_0000123 .

obo:UBERON_0002415 a rdfs:Class ;
  rdfs:label "tail" ;
  rdfs:comment "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:GO_0002250 a rdfs:Class ;
  rdfs:label "adaptive immune response" ;
  rdfs:comment "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." ;
  rdfs:subClassOf obo:GO_0006955 .

obo:OBI_2100189 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0200079 a rdfs:Class ;
  rdfs:label "arithmetic mean calculation"@en ;
  rdfs:comment "An arithmetic mean calculation is a descriptive statistics calculation in which the mean is calculated by taking the sum of all of the observations in a data set divided by the total number of observations. It gives a measure of the 'center of gravity' for the data set. It is also known as the first moment."@en ;
  rdfs:subClassOf obo:OBI_0200170 , obo:OBI_0200181 , obo:OBI_0200184 .

obo:OBI_0000391 a rdfs:Class ;
  rdfs:label "energy supply function"@en ;
  rdfs:comment "An energy supply function is a function to supply or transfer energy from an energy source to a consumer of the energy"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0500011 a rdfs:Class ;
  rdfs:label "latin square design" ;
  rdfs:comment "Latin square design is_a study design which allows in its simpler form controlling 2 levels of nuisance variables (also known as blocking variables).he 2 nuisance factors are divided into a tabular grid with the property that each row and each column receive each treatment exactly once."@en ;
  rdfs:subClassOf obo:OBI_0500007 .

obo:NCBITaxon_5820 a rdfs:Class ;
  rdfs:label "Plasmodium" ;
  rdfs:subClassOf obo:NCBITaxon_2759 .

obo:OBI_0000817 a rdfs:Class ;
  rdfs:label "fucoidan" ;
  rdfs:comment "Fucoidan is a sulfated polysaccharide (MW: average 20,000) found mainly in various species of brown seaweed such as kombu, limu moui,bladderwrack, wakame, mozuku, and hijiki (variant forms of fucoidan have also been found in animal species, including the sea cucumber)."@en ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002725 a rdfs:Class ;
  rdfs:label "insecticide resistance by fluorogenic PCR assay" ;
  rdfs:comment "An insecticide resistance assay that is based on monitoring known mutations by PCR technique that uses target specific probes labeled with fluorogenic chromophores to detect gene mutation."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0002696 .

obo:CHEBI_16247 a rdfs:Class ;
  rdfs:label "phospholipid" ;
  rdfs:comment "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0200139 a rdfs:Class ;
  rdfs:label "quantitative subgraph degree calculation"@en ;
  rdfs:comment "A network subgraph quality calculation in which an input data set describing subgraphs and quantitative relationship edges between subgraphs and other network objects is used to sum the quantitative relationships of an individual subgraph."@en ;
  rdfs:subClassOf obo:OBI_0200137 .

obo:OBI_0001648 a rdfs:Class ;
  rdfs:label "cross blocking assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A cross-blocking assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001699 , obo:OBI_0001703 .

obo:UBERON_0001530 a rdfs:Class ;
  rdfs:label "common carotid artery plus branches" ;
  rdfs:comment "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." ;
  rdfs:subClassOf obo:UBERON_0001637 .

obo:OBI_0001549 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to cell-bound-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001988 .

obo:OBI_0003491 a rdfs:Class ;
  rdfs:label "Panbio Dengue Early ELISA kit" ;
  rdfs:comment "An assay kit that is manufactured by Abbott to detect the NS1 Dengue viral protein with a protein microarray and an anti-NS1 monoclonal antibody."@en ;
  rdfs:subClassOf obo:OBI_0003369 .

obo:OBI_0001982 a rdfs:Class ;
  rdfs:label "protection from challenge in vivo intervention experiment" ;
  rdfs:comment "An in vivo intervention experiment that tests the ability of the intervention to prevent occurrence of a disease in a host."@en ;
  rdfs:subClassOf obo:OBI_0001980 .

obo:CHEBI_24875 a rdfs:Class ;
  rdfs:label "iron cation" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001261 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-1 alpha production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001388 .

obo:OBI_0000057 a rdfs:Class ;
  rdfs:label "allotransplantation"@en ;
  rdfs:comment "is the transplantation of organs between members of the same species."@en ;
  rdfs:subClassOf obo:OBI_0000105 .

obo:OBI_0001232 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific RANTES production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects RANTES production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001621 a rdfs:Class ;
  rdfs:label "longitude coordinate measurement datum"@en ;
  rdfs:comment "A measurement datum that is the measure of the longitude coordinate of a site."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0000785 a rdfs:Class ;
  rdfs:label "study design controlled variable"@en ;
  rdfs:comment "Controlled variable specification  is a part of a study design. They are the entities that could vary, but are kept constant to prevent their influence on the effect of the independent variable on the dependent."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:UBERON_0003126 a rdfs:Class ;
  rdfs:label "trachea" ;
  rdfs:comment "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003606 a rdfs:Class ;
  rdfs:label "Illumina NextSeq 1000" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation using sequence-by-synthesis chemistry that fits on a benchtop and uses P1 and P2 flow cells."@en ;
  rdfs:subClassOf obo:OBI_0003684 .

obo:OBI_0003339 a rdfs:Class ;
  rdfs:label "perfusion weighted magnetic resonance image data set" ;
  rdfs:comment "An magnetic resonance image data set that captures volume and flow of blood in the brain."@en ;
  rdfs:subClassOf obo:OBI_0003334 .

obo:OBI_0003493 a rdfs:Class ;
  rdfs:label "SD Bioline Chikungunya IgM capture ELISA kit" ;
  rdfs:comment "An assay kit that is manufactured by Abbott to detect human IgM antibodies for Chikungunya with a protein microarray and ELISA."@en ;
  rdfs:subClassOf obo:OBI_0003369 .

obo:OBI_0001518 a rdfs:Class ;
  rdfs:label "epitope specific tumor necrosis factor (ligand) superfamily member 11 production by T cells" ;
  rdfs:comment "A process of tumor necrosis factor (ligand) superfamily member 11 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0072535 , obo:OBI_0001351 .

obo:OBI_0002616 a rdfs:Class ;
  rdfs:label "genealogical record"@en ;
  rdfs:comment "A document about the family relationships of persons related as members of a domestic group linked through descent from a common ancestor, marriage, or adoption."@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0001695 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific immune complex formation" ;
  rdfs:comment "A B cell epitope specific activation of additional immune response assay that detects agglutination in vitro."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001704 .

obo:IAO_0000100 a rdfs:Class ;
  rdfs:label "homogenous data collection"@en ;
  rdfs:comment "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000345 a rdfs:Class ;
  rdfs:label "mass analyzer" ;
  rdfs:comment "A Mass analyzer is a device that separates ions according to their mass-to-charge ratio. All mass spectrometers are based on dynamics of charged particles in electric and magnetic fields in vacuum where the two laws of Lorentz force law and Newton's second law of motion apply."@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0000932 .

obo:OBI_2100103 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood nucleated RBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of nucleated RBCs in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:GO_0140730 a rdfs:Class ;
  rdfs:label "amphiregulin production" ;
  rdfs:comment "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_2100066 a rdfs:Class ;
  rdfs:label "CBC with automated differential venous blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a CBC with automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0003818 a rdfs:Class ;
  rdfs:label "crown rump length" ;
  rdfs:comment "A length measurement assay that measures the length of a neonate or fetus from crown of head to base of torso (rump)"@en ;
  rdfs:subClassOf obo:OBI_0003817 .

obo:OBI_0000729 a rdfs:Class ;
  rdfs:label "cloning plasmid" ;
  rdfs:comment "A cloning plasmid is a plasmid that was engineered to contain a bacterial origin of replication, encodes for a selectable gene product and contains a cloning site."@en ;
  rdfs:subClassOf obo:OBI_0000430 , obo:OBI_0000737 .

obo:RO_0000086 a rdf:Property ;
  rdfs:label "has quality"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:GO_0007283 a rdfs:Class ;
  rdfs:label "spermatogenesis" ;
  rdfs:comment "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." ;
  rdfs:subClassOf obo:GO_0022414 .

obo:OBI_0200027 a rdfs:Class ;
  rdfs:label "total intensity transformation paired"@en ;
  rdfs:comment "A total intensity transformation paired is a data transformation that takes as input two n-dimensional (real) vectors and multiplies each component of the first vector by a coefficient, where the coefficient is obtained by taking the ratio of the sum of the second input components or of a subset of these by the sum of the first input components or of a subset of these (the same subset is used for the two vectors)."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:IAO_8000002 a rdfs:Class ;
  rdfs:label "editors ontology module"@en ;
  rdfs:comment "An ontology module that is intended to be directly edited, typically managed in source control, and typically not intended for direct consumption by end-users."@en ;
  rdfs:subClassOf obo:IAO_8000000 .

obo:OBI_0001945 a rdfs:Class ;
  rdfs:label "scaffold N50"@en ;
  rdfs:comment "N50 statistic computed for the scaffold produced by the assembly process. The method for computing the value is similar to that of contig N50 but uses scaffold information instead of contig information"@en ;
  rdfs:subClassOf obo:OBI_0001940 .

obo:OBI_2100215 a rdfs:Class ;
  rdfs:label "hepatic panel venous blood human aspartate aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a hepatic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100019 .

obo:OBI_0002992 a rdfs:Class ;
  rdfs:label "prevalence of pathogen in specimens" ;
  rdfs:comment "A data item that is the frequency of detection of a specified pathogenic organism in collected specimens."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBA_2060184 a rdfs:Class ;
  rdfs:label "whole organism stability" ;
  rdfs:comment "The stability of a multicellular organism." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:OBI_0200043 a rdfs:Class ;
  rdfs:label "average linkage hierarchical clustering"@en ;
  rdfs:comment "An average linkage hierarchical clustering is an agglomerative hierarchical clustering which generates successive clusters based on a distance measure, where the distance between two clusters is calculated as the average distance between objects from the first cluster and objects from the second cluster."@en ;
  rdfs:subClassOf obo:OBI_0200154 .

obo:OBI_0003163 a rdfs:Class ;
  rdfs:label "methemoglobin percentage assay" ;
  rdfs:comment "A methemoglobin assay that measures the percentage of methemoglobin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100040 .

obo:OBI_0001806 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-27 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-27 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001198 .

obo:IAO_8000017 a rdfs:Class ;
  rdfs:label "ontology module subsetted by expressivity"@en ;
  rdfs:subClassOf obo:IAO_8000006 .

obo:GO_0071607 a rdfs:Class ;
  rdfs:label "macrophage inflammatory protein-1 gamma production" ;
  rdfs:comment "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0000893 a rdfs:Class ;
  rdfs:label "real time polymerase chain reaction assay" ;
  rdfs:comment "An assay, based on the PCR, that amplifies and simultaneously quantifies a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample."@en ;
  rdfs:subClassOf obo:OBI_0002692 .

obo:OBI_0002684 a rdfs:Class ;
  rdfs:label "nested polymerase chain reaction" ;
  rdfs:comment "A polymerase chain reaction with modification intended to reduce non-specific binding in products due to the amplification of unexpected primer binding sites. The nested polymerase chain reaction (PCR) involves the use of two primer sets and two successive PCR reactions. The first set of primers are designed to anneal to sequences upstream from the second set of primers and are used in an initial PCR reaction."@en ;
  rdfs:subClassOf obo:OBI_0000415 .

obo:MRO_0001434 a rdfs:Class ;
  rdfs:label "cattle MHC class I protein complex" ;
  rdfs:subClassOf obo:MRO_0001355 .

obo:OBI_0001572 a rdfs:Class ;
  rdfs:label "obsolete cell bound MHC binding constant determination assay" ;
  rdfs:comment "An assay that measures the affinity of a ligand to MHC moleculs bound to the cell surface and that quantifies the affinity with a binding constant."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000068 a rdfs:Class ;
  rdfs:label "reporting party role"@en ;
  rdfs:comment "a study personnel role played by a party who reports the outcome of a study component"@en ;
  rdfs:subClassOf obo:OBI_0000202 .

obo:OBI_0001212 a rdfs:Class ;
  rdfs:label "epitope specific type IV hypersensitivity by T cells" ;
  rdfs:comment "A process of type IV hypersensitivity by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0001806 .

obo:OBI_0200106 a rdfs:Class ;
  rdfs:label "discriminant analysis"@en ;
  rdfs:comment "Discriminant function analysis is used to determine which variables discriminate between two or more naturally occurring groups. Analysis is used to determine which variable(s) are the best predictors of a particular outcome."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0003546 a rdfs:Class ;
  rdfs:label "microarray ELISA measuring Chikungunya IgM antibody" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that uses a microarray as the solid support and detects the IgM antibody that binds Chikungunya."@en ;
  rdfs:subClassOf obo:OBI_0000661 .

obo:GO_0002027 a rdfs:Class ;
  rdfs:label "regulation of heart rate" ;
  rdfs:comment "Any process that modulates the frequency or rate of heart contraction." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:CHEBI_39025 a rdfs:Class ;
  rdfs:label "high-density lipoprotein" ;
  rdfs:comment "A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. They are synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport)." ;
  rdfs:subClassOf obo:CHEBI_6495 .

obo:CHMO_0000089 a rdfs:Class ;
  rdfs:label "confocal fluorescence microscopy assay" ;
  rdfs:comment "Microscopy where the specimen can be made to fluoresce (emit energy as visible light) by scanning a gas (Ar or Kr) laser spot of specific wavelength over its surface and using a spatial pinhole to eliminate out-of-focus fluorescence."@en ;
  rdfs:subClassOf obo:OBI_0002119 .

obo:CHEBI_47774 a rdfs:Class ;
  rdfs:label "low-density lipoprotein cholesterol" ;
  rdfs:comment "Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL)." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_1110014 a rdfs:Class ;
  rdfs:label "epitope binding by adaptive immune receptor"@en ;
  rdfs:comment "is the process in which an adaptive immune receptor binds to a material entity (realizing its disposition). The binding affinity is significant enough to trigger an immune response. Specifically, transient non-specific binding of adaptive immune receptors occurring during immune surveillance is not considered significant binding."@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001566 a rdfs:Class ;
  rdfs:label "50% dissociation of binding temperature (Tm)" ;
  rdfs:comment "A quantitative binding datum that specifies the temperature at which half of the binding partners are forming a complex and the other half are unbound."@en ;
  rdfs:subClassOf obo:OBI_0003142 .

obo:OBI_0003374 a rdfs:Class ;
  rdfs:label "remote patient assessment"@en ;
  rdfs:comment "An organism diagnostic process which involves a remote assessment of a patient by a clinician."@en ;
  rdfs:subClassOf obo:OBI_0003366 .

obo:GO_0007611 a rdfs:Class ;
  rdfs:label "learning or memory" ;
  rdfs:comment "The acquisition and processing of information and/or the storage and retrieval of this information over time." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003214 a rdfs:Class ;
  rdfs:label "progesterone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of progesterone"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003685 a rdfs:Class ;
  rdfs:label "Illumina NovaSeq series instrument" ;
  rdfs:comment "A DNA Sequencer manufactured and/or marketed by Illumina and branded with the word NovaSeq."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0003552 a rdfs:Class ;
  rdfs:label "proximity ligation-assisted ChIP-seq" ;
  rdfs:comment "A chromosome conformation capture assay in which proximity ligation is conducted in nuclei prior to chromatin shearing and immunoprecipitation. Immunopreciptation with an antibody that targets a transcription factor or histone modification allows for selection and enrichment of specific genomic regions for investigation of long-range chromosomal interactions."@en ;
  rdfs:subClassOf obo:OBI_0002439 .

obo:OBI_0003725 a rdfs:Class ;
  rdfs:label "survey administration assay" ;
  rdfs:comment "An assay that obtains data from one or more participants by using a survey or questionnaire"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003927 a rdfs:Class ;
  rdfs:label "read-based metagenome binning" ;
  rdfs:comment "A metagenome binning that clusters unassembled shotgun metagenomic reads de novo into bins by sequence composition, abundance, or overlap, without prior assembly into contigs and without comparison to a reference sequence database."@en ;
  rdfs:subClassOf obo:OBI_0003924 .

obo:OBI_0003245 a rdfs:Class ;
  rdfs:label "feces assay datum" ;
  rdfs:comment "A data entity that is the specified output of a feces assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:UBERON_0008188 a rdfs:Class ;
  rdfs:label "tendon of biceps brachii" ;
  rdfs:comment "A tendon that attaches_to a biceps brachii." ;
  rdfs:subClassOf obo:UBERON_0002384 .

obo:OBI_2100178 a rdfs:Class ;
  rdfs:label "quantitative venous blood IgM assay" ;
  rdfs:comment "An assay that measures IgM in venous blood as part of a quantitative order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0003206 a rdfs:Class ;
  rdfs:label "low-density lipoprotein concentration assay" ;
  rdfs:comment "A lipoprotein concentration assay that measures the concentration of low-density lipoprotein in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003204 .

obo:OBI_0001767 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 19 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-C motif) ligand 19 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001775 .

obo:OBI_0600028 a rdfs:Class ;
  rdfs:label "artificially induced reverse transcription"@en ;
  rdfs:comment "a protocol with the objective to transcribe single-stranded RNA into complementary DNA (cDNA)"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003595 a rdfs:Class ;
  rdfs:label "nasal lavage fluid" ;
  rdfs:comment "A specimen collected through nasal cavity lavage that contains the reagents used to for the lavage process, organisms, cells, cellular secretions, and other biomaterials present in the nasal cavity space."@en ;
  rdfs:subClassOf obo:OBI_0003666 .

obo:UBERON_0001558 a rdfs:Class ;
  rdfs:label "lower respiratory tract" ;
  rdfs:comment "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0100064 a rdfs:Class ;
  rdfs:label "screening library"@en ;
  rdfs:comment "a screening library is a collection of materials engineered to identify qualities of a subset of its members during a screening process?"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0001012 a rdfs:Class ;
  rdfs:label "RNASE V1 structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAse V1 as reagent and enzymatic probe"@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:OBI_0000590 a rdfs:Class ;
  rdfs:label "Bruker 1mm MicroProbe" ;
  rdfs:comment "Over the past few years there has been a significantly growing demand for miniaturization in all areas ofmodern research and development. Evoked by many exciting applications, there is a need for analytical methods which require less amounts of sample. Bruker BioSpin meets this challenge with a revolutionary NMR probe design: The 1mm MicroProbe. It operates with disposable 1mm capillary sample tubes and the sample volume of 5 microliters enables the use of lowest amounts of sample to run all high resolution NMR experiments with outstanding sensitivity and up to 16 times faster measurements. Due to the TXI-type probe design, the z-gradient coil and the automatic matching and tuning accessory, the 1mm MicroProbe can be used for a wide variety of NMR experiments. The key advantages of this probe include:n   up to 4 times higher mass sensitivity than 5mm conventional probes (with respect to the same sample amount)n   excellent solvent suppression propertiesn   virtually no salt effectn   discrete samples in tubes that can be sealed and storedn   automation accessory for sample preparation and handling available."@en ;
  rdfs:subClassOf obo:OBI_0000561 .

obo:OBI_0000962 a rdfs:Class ;
  rdfs:label "training objective" ;
  rdfs:comment "An objective specification which is fulfilled by the provision of some training."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0003285 a rdfs:Class ;
  rdfs:label "nasopharyngeal or oropharyngeal swab microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a nasopharyngeal or oropharyngeal swab specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:UBERON_0000992 a rdfs:Class ;
  rdfs:label "ovary" ;
  rdfs:comment "The gonad of a female organism which contains germ cells." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0001201 a rdfs:Class ;
  rdfs:label "epitope specific tolerance induction by T cells" ;
  rdfs:comment "A process of tolerance induction by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0002507 .

obo:OBI_0400135 a rdfs:Class ;
  rdfs:label "image cytometer" ;
  rdfs:comment "An image_cytometer is an instrument for image-based study or measurement of cells."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:GO_0008083 a rdfs:Class ;
  rdfs:label "growth factor activity" ;
  rdfs:comment "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." ;
  rdfs:subClassOf obo:GO_0003674 .

obo:GO_0001806 a rdfs:Class ;
  rdfs:label "type IV hypersensitivity" ;
  rdfs:comment "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." ;
  rdfs:subClassOf obo:GO_0002524 .

obo:OBI_0002504 a rdfs:Class ;
  rdfs:label "digestive system fluid or secretion specimen" ;
  rdfs:comment "A specimen that is derived from digestive system fluid or secretion."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:CHEBI_53526 a rdfs:Class ;
  rdfs:label "tritiated thymidine" ;
  rdfs:comment "Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002944 a rdfs:Class ;
  rdfs:label "sticky trap" ;
  rdfs:comment "An arthropod trap that is designed to capture arthropods resting on a surface by coating the surface with adhesive."@en ;
  rdfs:subClassOf obo:OBI_0002939 .

obo:OBI_0000281 a rdfs:Class ;
  rdfs:label "intraperitoneal injection" ;
  rdfs:comment "is the injection of a material entity (bearing the administered substance role) into the peritoneum (bearing the target role) of an organism using a syringe"@en ;
  rdfs:subClassOf obo:OBI_0000426 , obo:OBI_0000429 .

obo:OBI_0000814 a rdfs:Class ;
  rdfs:label "guar gum" ;
  rdfs:comment "Guar gum, also called guaran, is a galactomannan. It is primarily the ground endosperm of guar beans. The guar seeds are dehusked, milled and screened to obtain the guar gum.[1] It is typically produced as a free flowing, pale, off-white colored, coarse to fine ground powder."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0001003 a rdfs:Class ;
  rdfs:label "skin epidermis" ;
  rdfs:comment "The outer epithelial layer of the skin that is superficial to the dermis." ;
  rdfs:subClassOf obo:UBERON_0000483 , obo:UBERON_0003102 .

obo:PR_000050469 a rdfs:Class ;
  rdfs:label "hemoglobin A1c" ;
  rdfs:comment "A hemoglobin complex that is composed of at least one beta-N-1-deoxy fructosyl hemoglobin subunit, in which the glycan is attached to the N-terminal valine (after initiator methionine removal) of one or both beta subunits." ;
  rdfs:subClassOf obo:GO_0032991 .

obo:OBI_0500001 a rdfs:Class ;
  rdfs:label "clinical study design" ;
  rdfs:comment "Plan for the precise procedure to be followed in a clinical trial, including planned and actual timing of events, choice of control group, method of allocating treatments, blinding methods; assigns a subject to pass through one or more epochs in the course of a trial. Specific design elements, e.g., crossover, parallel; dose-escalation [Modified from Pocock, Clinical Trials: A Practical Approach]"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002977 a rdfs:Class ;
  rdfs:label "input gene sequence start site" ;
  rdfs:comment "The position of the first nucleotide in a gene sequence being analyzed (input gene sequence)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001185 a rdfs:Class ;
  rdfs:label "selectively maintained organism"@en ;
  rdfs:comment "An organism that is bred to have some uniform behavioral, morphological, physiological, or genetic characteristics with similarly bred organisms"@en ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0001745 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-1 alpha production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001388 , obo:OBI_0600031 .

obo:CL_0002319 a rdfs:Class ;
  rdfs:label "neural cell" ;
  rdfs:comment "A cell that is part of the nervous system." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0302729 a rdfs:Class ;
  rdfs:label "chemical solution"@en ;
  rdfs:comment "A material entity  that is made up of at least 2 scattered molecular aggregates, one playing the role of solvent and the other one playing the role of solute."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0001267 a rdfs:Class ;
  rdfs:label "epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "A process of transforming growth factor-beta production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071604 , obo:OBI_0001193 .

obo:OBI_0001454 a rdfs:Class ;
  rdfs:label "pathogenicity design" ;
  rdfs:comment "A study design in which an infective agent such as a bacterium, virus, protozoan, fungus etc. infects a host organism(s) and the infective agent is assayed."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001164 a rdfs:Class ;
  rdfs:label "age since sowing measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since sowing, the process of placing a seed or spore in some media with the intention to invoke germination."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0002798 a rdfs:Class ;
  rdfs:label "surgical gown" ;
  rdfs:comment "A medical gown which is subjected to a sterilization process and which is intended to be worn by a medical professional during surgical procedures."@en ;
  rdfs:subClassOf obo:OBI_0002796 .

obo:OBI_0002094 a rdfs:Class ;
  rdfs:label "MethylC-Capture sequencing assay" ;
  rdfs:comment "A bisulfite sequencing assay in which a whole-genome sequencing library is prepared, bisulfite converted and amplified, followed by a capture enriching for targeted bisulfite-converted DNA fragments that are are subsequently identified by DNA sequencing."@en ;
  rdfs:subClassOf obo:OBI_0000748 .

obo:OBI_0001748 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interferon-beta production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interferon-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001390 , obo:OBI_0600031 .

obo:OBI_0003505 a rdfs:Class ;
  rdfs:label "speech test assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to understandably repeat spoken sentences."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0001003 a rdfs:Class ;
  rdfs:label "agar stab storage" ;
  rdfs:comment "a storage process with input cell culture and agar and output agar stab for long time storage"@en ;
  rdfs:subClassOf obo:OBI_0302893 .

obo:OBI_0002477 a rdfs:Class ;
  rdfs:label "reference genome role"@en ;
  rdfs:comment "A reference substance role that is played by a reference genome when used during sequence alignment."@en ;
  rdfs:subClassOf obo:OBI_0000025 .

obo:IAO_0000572 a rdfs:Class ;
  rdfs:label "documenting"@en ;
  rdfs:comment "A planned process in which a document is created or added to by including the specified input in it."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:PATO_0002198 a rdfs:Class ;
  rdfs:label "quality of a substance" ;
  rdfs:comment "A quality inhering in a bearer by virtue of its constitution." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0000658 a rdfs:Class ;
  rdfs:label "data representational model" ;
  rdfs:comment "An information content entity representing the relationships between data items."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:GO_0048856 a rdfs:Class ;
  rdfs:label "anatomical structure development" ;
  rdfs:comment "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0002164 a rdfs:Class ;
  rdfs:label "mammalian 2-hybrid assay" ;
  rdfs:comment "A binding assay that increases the expression of a reporter gene in mammalian cells by proteins of interest attached to two portions of the transcriptional activator, bringing those portions closer together."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0200173 a rdfs:Class ;
  rdfs:label "background correction objective"@en ;
  rdfs:comment "A background correction objective is a data transformation objective where the aim is to remove irrelevant contributions from the measured signal, e.g. those due to instrument noise or sample preparation."@en ;
  rdfs:subClassOf obo:OBI_0200168 .

obo:OBI_0000092 a rdfs:Class ;
  rdfs:label "role of certified IRB professional"@en ;
  rdfs:comment "a role of which inheres in a Homo sapiens and realized during administration and oversight of the daily activities of Institutional Review Boards (IRBs) in the USA"@en ;
  rdfs:subClassOf obo:OBI_0000016 .

obo:CHEBI_145810 a rdfs:Class ;
  rdfs:label "insulin" ;
  rdfs:comment "A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the β cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies." ;
  rdfs:subClassOf obo:CHEBI_16670 .

obo:OBI_0001879 a rdfs:Class ;
  rdfs:label "reagent"@en ;
  rdfs:comment "A biological or chemical entity that bears a reagent role in virtue of it being intended for application in a scientific technique  to participate in (or have molecular parts that participate in) a chemical reaction that facilitates the generation of data about some distinct entity, or the generation of some distinct material specified output."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:BFO_0000023 a rdfs:Class ;
  rdfs:label "role"@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:OBI_0000603 a rdfs:Class ;
  rdfs:label "liquid chromatography column" ;
  rdfs:comment "A liquid chromatography column is a chromatography column that is used in liquid chromatography, i.e. a column that is provided with a liquid sample mix."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0003217 a rdfs:Class ;
  rdfs:label "testosterone concentration assay" ;
  rdfs:comment "A testosterone assay that measures the concentration of testosterone in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003216 .

obo:OBI_0001470 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-17F production by T cells" ;
  rdfs:comment "A process of interleukin-17F production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0097088 , obo:OBI_1110193 .

obo:PATO_0002003 a rdfs:Class ;
  rdfs:label "population quality" ;
  rdfs:comment "A quality that inheres in an entire population or part of a population." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBI_0400049 a rdfs:Class ;
  rdfs:label "Guava EasyCyte Plus" ;
  rdfs:comment "A Guava_EasyCyte_Plus System is a flow_cytometer_analyser that includes a single 488 nm laser, and filters and PMTs to collect up to 4 fluorescent parameters. It includes a photodiode forward scatter collector and an optional photodiode for side scatter collection.Guava cytometers use aspiration instead of fluid systems to transport cells within the machine. The EasyCyte plus accepts 96 well plates as well as tubes. The Guava_EasyCyte_Plus cytometer is a small portable cytometer particularly useful for field measurement."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0003766 a rdfs:Class ;
  rdfs:label "estrous cycle assay based on tissue morphology" ;
  rdfs:comment "A histological assay that evaluates cells in the vaginal endometrium to assess the estrous cycle phase the subject was in at the time of specimen collection."@en ;
  rdfs:subClassOf obo:OBI_0600020 .

obo:OBI_0001752 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific granulocyte colony stimulating factor production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects granulocyte colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001600 .

obo:PATO_0001293 a rdfs:Class ;
  rdfs:label "absorption quality" ;
  rdfs:comment "A scalar EM radiation quality which obtains by the capacity of the bearer to retain radiation." ;
  rdfs:subClassOf obo:PATO_0001292 .

obo:OBI_0003270 a rdfs:Class ;
  rdfs:label "virus in induced sputum datum" ;
  rdfs:comment "An induced sputum microbiology datum that is about a virus."@en ;
  rdfs:subClassOf obo:OBI_0003251 .

obo:GO_0071753 a rdfs:Class ;
  rdfs:label "IgM immunoglobulin complex" ;
  rdfs:comment "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ;
  rdfs:subClassOf obo:GO_0019814 .

obo:GO_0016477 a rdfs:Class ;
  rdfs:label "cell migration" ;
  rdfs:comment "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_2100212 a rdfs:Class ;
  rdfs:label "hepatic panel venous blood protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in venous blood as part of a hepatic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0002486 a rdfs:Class ;
  rdfs:label "verse algorithm"@en ;
  rdfs:comment "An alignment counting algorithm that assigns gene features to genomic alignments using a hierarchical assignment scheme, which allows simultaneous quantification of multiple feature types or annotation levels without repeatedly assigning reads."@en ;
  rdfs:subClassOf obo:OBI_0002466 .

obo:GO_0090128 a rdfs:Class ;
  rdfs:label "regulation of synapse maturation" ;
  rdfs:comment "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:CHEBI_30222 a rdfs:Class ;
  rdfs:label "neutron" ;
  rdfs:comment "Nuclear particle of zero charge, spin 1/2 and rest mass of 1.008664904(14) u." ;
  rdfs:subClassOf obo:CHEBI_36342 .

obo:OBI_0000380 a rdfs:Class ;
  rdfs:label "gas filter function"@en ;
  rdfs:comment "A gas filter function is a filter function which prevents the flow of solid objects, defined by specific qualities, in a gas-solid mixture"@en ;
  rdfs:subClassOf obo:OBI_0000378 .

obo:OBI_0003776 a rdfs:Class ;
  rdfs:label "synapse per neuron assay" ;
  rdfs:comment "A regulation of synapse maturation assay that determines the number of synaptic puncta in a culture and normalizes it by the number of neurons in the culture."@en ;
  rdfs:subClassOf obo:OBI_0003753 .

obo:OBI_0100010 a rdfs:Class ;
  rdfs:label "Epstein Barr virus transformed B cell"@en ;
  rdfs:comment "A material entity which results from viral transformation process using EBV as transformation agent when applied to B-cell entity"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000243 a rdfs:Class ;
  rdfs:label "sponsor role"@en ;
  rdfs:comment "a responsible party role involved with any of the following activities:  initiating, managing and funding a study"@en ;
  rdfs:subClassOf obo:OBI_0000102 .

obo:OBI_0001217 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-22 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_2100142 a rdfs:Class ;
  rdfs:label "cooximitery arterial blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a cooximitery order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0000505 a rdfs:Class ;
  rdfs:label "multiple wavelength detector" ;
  rdfs:comment "A chromatography detector, that can detect many discrete wavelengths in parallel and produces a multiple wavelength chromatographic profile."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001290 a rdfs:Class ;
  rdfs:label "transcription profiling by array design" ;
  rdfs:comment "A study design that identifies forms and abundance of transcripts in the genome using microarray technology."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:UBERON_0010414 a rdfs:Class ;
  rdfs:label "omental fat pad" ;
  rdfs:comment "Encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon." ;
  rdfs:subClassOf obo:UBERON_0001013 .

obo:GO_0097280 a rdfs:Class ;
  rdfs:label "histamine secretion mediated by immunoglobulin" ;
  rdfs:comment "Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface." ;
  rdfs:subClassOf obo:GO_0006955 .

obo:OBI_0001293 a rdfs:Class ;
  rdfs:label "disease state design" ;
  rdfs:comment "A study design in which the pathological condition of a part, organ, or system of an organism is studied. The etiology may be from infection, genetic defect, or environmental stress."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003273 a rdfs:Class ;
  rdfs:label "eukaryota in lung datum" ;
  rdfs:comment "A lung microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003256 .

obo:OBI_0001971 a rdfs:Class ;
  rdfs:label "Ion 316 Chip v2" ;
  rdfs:comment "An ion semiconductor chip manufactured by Life Technologies which detects polymerase-driven base incorporation to translate into digital form. The 316 chip is compatible with the Ion Torrent PGM and has a run time of: 3.0 hours for 200 bp reads with an output of 30-50 Mb, 4.9 hours for 400 bp reads with an output of 60 Mb-1 Gb."@en ;
  rdfs:subClassOf obo:OBI_0001973 .

obo:OBI_0200155 a rdfs:Class ;
  rdfs:label "divisive hierarchical clustering"@en ;
  rdfs:comment "A divisive hierarchical clustering is a hierarchical clustering which starts with a single cluster and then successively splits resulting clusters until only clusters of individual objects remain."@en ;
  rdfs:subClassOf obo:OBI_0200042 .

obo:OBI_0000524 a rdfs:Class ;
  rdfs:label "Varian VXR spectrometer" ;
  rdfs:comment "A Varian NMR spectrometer."@en ;
  rdfs:subClassOf obo:OBI_0000611 .

obo:GO_0008150 a rdfs:Class ;
  rdfs:label "biological_process" ;
  rdfs:comment "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBI_0002689 a rdfs:Class ;
  rdfs:label "detection of pathogenic organisms objective" ;
  rdfs:comment "An organism feature identification objective that aims to detect whether an organism contains pathogenic organisms."@en ;
  rdfs:subClassOf obo:OBI_0000268 .

obo:OBI_0000984 a rdfs:Class ;
  rdfs:label "dose" ;
  rdfs:comment "A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0001380 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-18 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-18 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0003337 a rdfs:Class ;
  rdfs:label "resting state functional magnetic resonance image data set" ;
  rdfs:comment "A type of functional MRI in which the participant is not given a task, but just rests during acquisision"@en ;
  rdfs:subClassOf obo:OBI_0003336 .

obo:CL_0002192 a rdfs:Class ;
  rdfs:label "metamyelocyte" ;
  rdfs:comment "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:GO_0031175 a rdfs:Class ;
  rdfs:label "neuron projection development" ;
  rdfs:comment "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0000889 a rdfs:Class ;
  rdfs:label "survival curve"@en ;
  rdfs:comment "A survival curve is a report graph which is a graphical representation of data where the percentage of survival is plotted as a function of time."@en ;
  rdfs:subClassOf obo:IAO_0000573 .

obo:OBI_2100160 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood alanine aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100016 .

obo:OBI_0400077 a rdfs:Class ;
  rdfs:label "neodymium-YAG laser" ;
  rdfs:comment "A Neodymium-YAG (yttrium aluminum garnet) laser is a solid state laser in which the lasing medium is a solid rod of crystalline material pumped by a flash lamp or a diode laser. Typical output wavelengths are 355, 532, and 1064 nm. A neodymium-YAG laser can by used to irradiate cells in a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400096 .

obo:OBI_0000639 a rdfs:Class ;
  rdfs:label "material separation objective" ;
  rdfs:comment "is an objective to transform a material entity into spatially separated components."@en ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:OBI_0500022 a rdfs:Class ;
  rdfs:label "stopping rule"@en ;
  rdfs:comment "a stopping rule (criterion) is_a *rule* which causes a *stopping process* to happen"@en ;
  rdfs:subClassOf obo:IAO_0000055 .

obo:OBI_2100234 a rdfs:Class ;
  rdfs:label "total venous blood IgE assay" ;
  rdfs:comment "An assay that measures IgE in venous blood as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0002750 a rdfs:Class ;
  rdfs:label "Oxford Nanopore MinION" ;
  rdfs:comment "A portable DNA sequencer which is manufactured by the Oxford Nanopore Technologies corporation, that uses consumable flow cells producing up to 30 Gb of DNA sequence data per flow cell. The sequencer produces real-time results and utilizes nanopore technology with up to 512 nanopore channels in the sensor array."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0001789 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific RANTES production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects RANTES production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001232 .

obo:OBI_1110031 a rdfs:Class ;
  rdfs:label "EL-4 cell line"@en ;
  rdfs:comment "A cell line derived from mouse (C57BL/6N) lymphoma cells."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0000926 a rdfs:Class ;
  rdfs:label "obsolete_ambidexterious handedness" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100226 a rdfs:Class ;
  rdfs:label "chem11 venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0003467 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from other challenge" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from a challenge other than pathogen, infection, or tumor."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0001710 .

obo:GO_0044807 a rdfs:Class ;
  rdfs:label "macrophage migration inhibitory factor production" ;
  rdfs:comment "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003363 a rdfs:Class ;
  rdfs:label "T2 FLAIR lesion mask" ;
  rdfs:comment "A lesion mask where the lesions are derived from a T2 FLAIR image data set."@en ;
  rdfs:subClassOf obo:OBI_0003361 .

obo:OBI_0000838 a rdfs:Class ;
  rdfs:label "material maintenance" ;
  rdfs:comment "A planned process with the objective to maintain some or all of the characteristics of an input material over time."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBA_0000001 a rdfs:Class ;
  rdfs:label "biological attribute" ;
  rdfs:subClassOf obo:COB_0000502 .

obo:OBI_0001740 a rdfs:Class ;
  rdfs:label "quenching assay measuring the off rate [koff] of a B cell epitope:antibody complex" ;
  rdfs:comment "A fluorescence quenching assay that measures the off rate [koff] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001635 , obo:OBI_0001723 .

obo:CHEBI_31643 a rdfs:Class ;
  rdfs:label "gadoteridol" ;
  rdfs:comment "A non-ionic gadolinium chelate having a macrocyclic tetraamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI)." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002143 a rdfs:Class ;
  rdfs:label "bromouride labeling and sequencing after UV exposure" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay used to identify transcription start sites and active enhancer elements through isolation of bromouridine (Bru) labelled RNAs after UV light exposure introduces transcription-blocking lesions."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0000957 a rdfs:Class ;
  rdfs:label "self reported handedness assessment" ;
  rdfs:comment "An assay where a person makes a statement that indicates what handedness he has from a choice of different categories."@en ;
  rdfs:subClassOf obo:OBI_0000944 .

obo:OBI_1110202 a rdfs:Class ;
  rdfs:label "epitope specific IL-5 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-5 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032634 , obo:OBI_0001193 .

obo:OBI_0001289 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-5 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-5 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001230 , obo:OBI_0003115 .

obo:UBERON_0000105 a rdfs:Class ;
  rdfs:label "life cycle stage" ;
  rdfs:comment "A spatiotemporal region encompassing some part of the life cycle of an organism." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001432 a rdfs:Class ;
  rdfs:label "operon identification design" ;
  rdfs:comment "A study design that identifies locations and members of operons in a genome."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002572 a rdfs:Class ;
  rdfs:label "polyA-depleted RNA sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay to study non-polyadenylated transcripts, such as, but not exclusive to unspliced and circular isoforms, through the depletion of polyadenylated transcripts prior to high-throughput sequencing."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0000543 a rdfs:Class ;
  rdfs:label "syringe filter" ;
  rdfs:comment "A small membrane filter of defined pore size, that filters samples from a syringe."@en ;
  rdfs:subClassOf obo:OBI_0000592 .

obo:OBI_0001426 a rdfs:Class ;
  rdfs:label "sex comparison design" ;
  rdfs:comment "A study design that assays differences associated with an organism's sex, gender or mating type."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:GO_0042575 a rdfs:Class ;
  rdfs:label "DNA polymerase complex" ;
  rdfs:comment "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." ;
  rdfs:subClassOf obo:GO_0032991 , obo:OBI_0000427 .

obo:PATO_0001019 a rdfs:Class ;
  rdfs:label "mass density" ;
  rdfs:comment "A physical quality which inheres in a bearer by virtue of some influence is exerted by the bearer's mass per unit size." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0002455 a rdfs:Class ;
  rdfs:label "clinically relevant exposure inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states one or more clinically relevant histories of exposure of an entity, which, if met, makes the entity suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0003307 a rdfs:Class ;
  rdfs:label "multi-contact Hi-C assay" ;
  rdfs:comment "A Hi-C assay that assesses interactions between multiple DNA fragments rather than only pairwise interactions as in traditional Hi-C. The experimental procedure of cross-linking, digestion, and ligation is performed similarly to traditional Hi-C, but after DNA is purified a long-read library is produced in which many ligated fragments may be contained in a single molecule. The library is then sequenced on a long read sequencer."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:OBI_0001163 a rdfs:Class ;
  rdfs:label "age since eclosion measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since eclosion, the process of emergence of an adult insect from its pupa or cocoon."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0001341 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects granulocyte macrophage colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001233 .

obo:OBI_0003900 a rdfs:Class ;
  rdfs:label "telemeter sensor detection assay" ;
  rdfs:comment "An assay which uses an implanted telemeter to measure physiological data in a living organism and transmit the measures via radio waves to a recording device."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001034 a rdfs:Class ;
  rdfs:label "environmental control device" ;
  rdfs:comment "An environmental control device is a device which has the function to control some aspect of the environment such as temperature, or humidity."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003573 a rdfs:Class ;
  rdfs:label "intrarectal administration" ;
  rdfs:comment "An administration of a substance into the rectum of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0003754 a rdfs:Class ;
  rdfs:label "Ames assay" ;
  rdfs:comment "A cell based DNA damage assay that uses several constructed bacterial strains to detect mutations."@en ;
  rdfs:subClassOf obo:OBI_0003721 .

obo:OBI_0000662 a rdfs:Class ;
  rdfs:label "error corrected data set"@en ;
  rdfs:comment "A data set that is produced as the output of an error correction data transformation and consists of producing a data set which has had erroneous contributions from the input to the data transformation removed (corrected for)."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0600032 a rdfs:Class ;
  rdfs:label "artificially induced DNA repair"@en ;
  rdfs:comment "a protocol application to repair damaged DNA molecules"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000977 a rdfs:Class ;
  rdfs:label "paraffin storage" ;
  rdfs:comment "a storage process with input organism or anatomical entity and paraffin and output material embedded in paraffin for long term storage"@en ;
  rdfs:subClassOf obo:OBI_0302893 .

obo:PATO_0001422 a rdfs:Class ;
  rdfs:label "dead" ;
  rdfs:comment "A viability quality inhering in a bearer by virtue of the cessation of the bearer's life." ;
  rdfs:subClassOf obo:PATO_0000169 .

obo:OBI_0000799 a rdfs:Class ;
  rdfs:label "recombinant phage cloning" ;
  rdfs:comment "Recombinant phage cloning is the process of using a phage plus some insert nucleic acid for the purposes of amplification of the insert material achieved by phage assembly in vitro."@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_0000710 a rdfs:Class ;
  rdfs:label "Li-Cor 4300 DNA Analysis System" ;
  rdfs:comment "is a DNA sequencer which is manufactured by Li-Cor corporation and enable automated chain termination based DNA sequencing"@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0000572 a rdfs:Class ;
  rdfs:label "transfer line" ;
  rdfs:comment "A combination of devices that are used in connection with a sampling head for transferring components of an applied sample to the analyzing part of a chromatography system."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0002967 a rdfs:Class ;
  rdfs:label "microwestern meso-scale quantitative western blot assay" ;
  rdfs:comment "A western blot assay that provides a high-throughput, sensitive, and quantitative measurement of proteins from numerous samples via an array of small western blots on a single sheet of nitrocellulose."@en ;
  rdfs:subClassOf obo:OBI_0000854 .

obo:OBI_0002761 a rdfs:Class ;
  rdfs:label "lipid profiling assay" ;
  rdfs:comment "An analyte assay assay that detects and identifies lipids resulting from biochemical and cellular metabolism."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003844 a rdfs:Class ;
  rdfs:label "developmental marker age of attainment assessment" ;
  rdfs:comment "An age determination assay which determines the age of the subject at the time of the change from a state where it did not have a developmental stage marker to one in which it does."@en ;
  rdfs:subClassOf obo:OBI_0001158 .

obo:OBI_2100342 a rdfs:Class ;
  rdfs:label "liver function venous blood protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in venous blood as part of a liver function order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_2100131 a rdfs:Class ;
  rdfs:label "venous blood folic acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of folic acid in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100037 .

obo:OBI_0003801 a rdfs:Class ;
  rdfs:label "urine opacity assay" ;
  rdfs:comment "A histological assay with urine evaluant that measures opacity of the urine"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_0600020 .

obo:OBI_0003427 a rdfs:Class ;
  rdfs:label "aspartate aminotransferase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of aspartate aminotransferase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:NCBITaxon_5140 a rdfs:Class ;
  rdfs:label "Neurospora" ;
  rdfs:subClassOf obo:NCBITaxon_716545 .

obo:PATO_0001196 a rdfs:Class ;
  rdfs:label "ventral to" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the abdomen of an organism relative to another entity." ;
  rdfs:subClassOf obo:PATO_0000140 .

obo:CHEBI_51232 a rdfs:Class ;
  rdfs:label "2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002561 a rdfs:Class ;
  rdfs:label "sex inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states one or more sexes which, if met, makes an entity suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0004002 a rdfs:Class ;
  rdfs:label "non-randomized clinical trial"@en ;
  rdfs:comment "A clinical trial in which the participants are not assigned by chance to different treatment groups. Participants may choose which group they want to be in, or they may be assigned to the groups by the researchers."@en ;
  rdfs:subClassOf obo:OBI_0003699 .

obo:GO_0003674 a rdfs:Class ;
  rdfs:label "molecular_function" ;
  rdfs:comment "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBI_0003126 a rdfs:Class ;
  rdfs:label "neuron morphology reconstruction assay" ;
  rdfs:comment "A neuron morphology assay where the morphology or structure of a neuron is represented. Often, this assay is a combination of different assays (sparse labelling, fluorescent labeling, fMOST)."@en ;
  rdfs:subClassOf obo:OBI_0003124 .

obo:CL_0000625 a rdfs:Class ;
  rdfs:label "CD8-positive, alpha-beta T cell" ;
  rdfs:comment "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." ;
  rdfs:subClassOf obo:CL_0000789 .

obo:OBI_0302894 a rdfs:Class ;
  rdfs:label "cell lysis"@en ;
  rdfs:comment "cell lysis is a process by which cell membrane integrity of live cells  is compromised and leads to cell death. Cell lysis may be achieved by means of viral action or osmotic shock."@en ;
  rdfs:subClassOf obo:OBI_0600006 .

obo:OBI_0000264 a rdfs:Class ;
  rdfs:label "obsolete_sample population" ;
  rdfs:comment "A sample population is an object aggregate that is selected from the population, e.g. the fish in the net that were sampled from the lake, the people that responded to the call for volunteers."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001271 a rdfs:Class ;
  rdfs:label "transcription profiling by RNA sequencing assay" ;
  rdfs:comment "A type of transcription profiling assay where transcripts are extracted from a sample, usually (but not always) transformed into cDNA, and then sequenced. Sequence reads are generally mapped to a reference and quantified to establish levels of gene transcription."@en ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_0400027 a rdfs:Class ;
  rdfs:label "CytoBuoy flow cytometer analyzer" ;
  rdfs:comment "A flow cytometer analyser which is manufactured by Cyto Buoy Inc. They are the buoy mounted version of the CytoSense, equipped with wireless transmission of control and data files. They are a single laser, multi parameter instrument. Various types of micro-laser are offered; available measuring parameters are forward light scatter, side scatter, and fluorescence (max. 9 colour bands). The current series have 5 parameters."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0003228 a rdfs:Class ;
  rdfs:label "fluorescent immunospot assay" ;
  rdfs:comment "A cytometry assay that detects the presence of cells that secrete a material of interest (analyte). In the assay, a plate is coated with an antibody specific to the analyte of interest. These antibodies capture the analytes secreted by the cells. The analytes are then detected using fluorescent labeled secondary antibodies."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:GO_0071612 a rdfs:Class ;
  rdfs:label "IP-10 production" ;
  rdfs:comment "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0003304 a rdfs:Class ;
  rdfs:label "single nucleus Hi-C assay" ;
  rdfs:comment "A Hi-C assay performed on isolated nuclei."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:OBI_1110300 a rdfs:Class ;
  rdfs:label "direct submission to IEDB" ;
  rdfs:comment "A report about experiments in an investigation that characterize immune epitopes, and was submitted directly by the authors to the Immune Epitope Database (IEDB)"@en ;
  rdfs:subClassOf obo:IAO_0000088 .

obo:OBI_0302888 a rdfs:Class ;
  rdfs:label "washing"@en ;
  rdfs:comment "washing is a process by which a material entity acting as  contaminant (e.g. excess staining reagent) is removed by application of one or more cycles of solution in flow."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003251 a rdfs:Class ;
  rdfs:label "induced sputum microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of an induced sputum microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003249 .

obo:NCBITaxon_8353 a rdfs:Class ;
  rdfs:label "Xenopus <genus>" ;
  rdfs:subClassOf obo:NCBITaxon_32523 .

obo:OBI_0000822 a rdfs:Class ;
  rdfs:label "single blind study execution" ;
  rdfs:comment "A single blind study execution is defined as any study execution in which the subjects are not informed of which study arm they are part of during the portion of the trial when the subjects are being treated"@en ;
  rdfs:subClassOf obo:OBI_0000826 .

obo:OBI_2100119 a rdfs:Class ;
  rdfs:label "venous blood thyroid stimulating hormone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of thyroid stimulating hormone in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100033 .

obo:OBI_0001914 a rdfs:Class ;
  rdfs:label "multiplex ligation-mediated amplification"@en ;
  rdfs:comment "A polymerase chain reaction that amplifies multiple targets with a single primer pair mediated by hybridization of a primer with its target sequence using ligation."@en ;
  rdfs:subClassOf obo:OBI_0000415 .

obo:OBI_0002201 a rdfs:Class ;
  rdfs:label "determination if assay will provide reliable results" ;
  rdfs:comment "A planned process that is used to assess whether an assay will provide reliable results based on the conditions or qualities of the inputs, devices, and other participants of the assay."@en ;
  rdfs:subClassOf obo:COB_0000082 .

obo:OBI_0000383 a rdfs:Class ;
  rdfs:label "transfer function"@en ;
  rdfs:comment "A transfer function is a function to displace a material from one location to another."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OMRSE_00000054 a rdfs:Class ;
  rdfs:label "hospital role"@en ;
  rdfs:comment "A healthcare provider role that inheres in an organization and is realized by providing inpatient care."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_2100380 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0001298 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-21 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001237 .

obo:OBI_0000509 a rdfs:Class ;
  rdfs:label "electron capture detector" ;
  rdfs:comment "The electron capture detector is a GC detector that uses a radioactive Beta emitter (electrons) to ionize some of the carrier gas and produce a current between a biased pair of electrodes. When organic molecules that contain electronegative functional groups, such as halogens, phosphorous, and nitro groups pass by the detector, they capture some of the electrons and reduce the current measured between the electrodes."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_0001148 a rdfs:Class ;
  rdfs:label "gene knock out"@en ;
  rdfs:comment "a genetic transformation that renders a gene non-functional, e.g. due to a point mutation, or the removal of all, or part of, the gene using recombinant methods."@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_1110151 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001414 .

obo:OBI_0001330 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects chemokine (C-X-C motif) ligand 9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001459 .

obo:OBI_0002787 a rdfs:Class ;
  rdfs:label "face mask" ;
  rdfs:comment "A personal protective device worn over the nose and mouth as a respiratory filter to inhibit the flow of particles."@en ;
  rdfs:subClassOf obo:OBI_0002786 .

obo:OBI_0000131 a rdfs:Class ;
  rdfs:label "molecular feature identification objective"@en ;
  rdfs:comment "Molecular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features of a biological system, e.g. expression profiling, copy number of molecular components, epigenetic modifications."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0200076 a rdfs:Class ;
  rdfs:label "column submatrix extraction"@en ;
  rdfs:comment "A column submatrix extraction is a submatrix extraction where all the rows of the input matrix are retained and selection only occurs on the columns."@en ;
  rdfs:subClassOf obo:OBI_0200074 .

obo:OBI_0000751 a rdfs:Class ;
  rdfs:label "study design dependent variable"@en ;
  rdfs:comment "dependent variable specification is part of a study design. The dependent variable is the event studied and expected to change when the independent variable varies."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:NCBITaxon_11646 a rdfs:Class ;
  rdfs:label "Lentivirus" ;
  rdfs:subClassOf obo:NCBITaxon_2732514 .

obo:OBI_0000427 a rdfs:Class ;
  rdfs:label "enzyme"@en ;
  rdfs:comment """(protein or rna) or has_part (protein or rna) and
has_function some GO:0003824 (catalytic activity)"""@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0200057 a rdfs:Class ;
  rdfs:label "replicate analysis"@en ;
  rdfs:comment "A replicate analysis is a data transformation in which data from replicates are combined, e.g. through descriptive statistics calculations, and the results might be utilized for a variety of purposes, like assessing reproducibility, identifying outliers, normalizing, etc."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0600014 a rdfs:Class ;
  rdfs:label "material component separation"@en ;
  rdfs:comment "a material processing in which components of an input material become segregated in space"@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0001923 a rdfs:Class ;
  rdfs:label "protein sequencing by tandem mass spectrometry assay" ;
  rdfs:comment "A sequencing assay that detremines amino acid sequences of proteins using multiple rounds of mass spectrometry and molecule fragmentation."@en ;
  rdfs:subClassOf obo:OBI_0000470 , obo:OBI_0600047 .

obo:OBI_0000248 a rdfs:Class ;
  rdfs:label "feed role"@en ;
  rdfs:comment "a role that inheres in a material entity and is realized in the use of that material entity by lab animal to provide all needed nourishment."@en ;
  rdfs:subClassOf obo:OBI_0000162 .

obo:CHEBI_17423 a rdfs:Class ;
  rdfs:label "methemoglobin" ;
  rdfs:comment "A hemoprotein that is the ferric (Fe<small><sup>3+</small></sup>) form of hemoglobin." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003072 a rdfs:Class ;
  rdfs:label "axillary temperature measurement datum" ;
  rdfs:comment "A temperature measurement datum that is about an axilla."@en ;
  rdfs:subClassOf obo:OBI_0003079 .

obo:OBI_0003487 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-25 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-25 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0003484 .

obo:OBI_0001540 a rdfs:Class ;
  rdfs:label "obsolete T cell recognition of eluted MHC ligand assay" ;
  rdfs:comment "An assay that identifies an MHC ligand using a T cell response assay as a readout"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002416 a rdfs:Class ;
  rdfs:label "exposure to arsenic history" ;
  rdfs:comment "An exposure to environmental and workplace carcinogens history where the carcinogen is arsenic."@en ;
  rdfs:subClassOf obo:OBI_0002415 .

obo:OBI_0002962 a rdfs:Class ;
  rdfs:label "kinase inhibitor assay" ;
  rdfs:comment "A type of assay that identifies compounds that inhibit the activity of kinases."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000651 a rdfs:Class ;
  rdfs:label "urine specimen" ;
  rdfs:comment "a portion of urine collected from an organism"@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:IAO_8000013 a rdfs:Class ;
  rdfs:label "reasoned ontology module"@en ;
  rdfs:comment "An ontology module that contains axioms generated by a reasoner. The generated axioms are typically direct SubClassOf axioms, but other possibilities are available."@en ;
  rdfs:seeAlso <http://robot.obolibrary.org/reason> ;
  rdfs:subClassOf obo:IAO_8000000 .

obo:OBI_0001868 a rdfs:Class ;
  rdfs:label "genetic material" ;
  rdfs:comment "A nucleic acid macromolecule that is part of a cell or virion and is inherited from an immediate ancestor, or incorporated in a manner that it has the disposition to be replicated and inherited by descendants."@en ;
  rdfs:subClassOf obo:CHEBI_33696 .

obo:OBI_0003033 a rdfs:Class ;
  rdfs:label "cleavage under targets and release using nuclease assay" ;
  rdfs:comment "A type of DNA sequencing assay employing in situ chromatin profiling in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific protein-DNA complexes into the the supernatant for sequencing."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:PATO_0001338 a rdfs:Class ;
  rdfs:label "mixed sex" ;
  rdfs:comment "A biological sex quality inhering in a population of multiple sexes." ;
  rdfs:subClassOf obo:PATO_0002003 .

obo:OBI_0002776 a rdfs:Class ;
  rdfs:label "cytometry analysis by automated gating" ;
  rdfs:comment "A gating in which the output of a flow- or mass- cytometry experiment is separated into gates that were set by an algorithm in order to quantify the frequency of different cell populations of interest."@en ;
  rdfs:subClassOf obo:OBI_0200077 .

obo:OBI_0001126 a rdfs:Class ;
  rdfs:label "digital microscope" ;
  rdfs:comment "A microscope that uses optics and a charge-coupled device (CCD) camera to output a digital image to a monitor."@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:OBI_0003513 a rdfs:Class ;
  rdfs:label "muscle atrophy assessment" ;
  rdfs:comment "An observational assesment of an individual's muscle tissue loss due to inactivity or disease."@en ;
  rdfs:subClassOf obo:OBI_0003536 .

obo:OBI_0000162 a rdfs:Class ;
  rdfs:label "complete nutrient role"@en ;
  rdfs:comment "A nutrient role that inheres in a material entity and is realized in the use of that material entity by an organism to provide all needed nourishment."@en ;
  rdfs:subClassOf obo:OBI_0000204 .

obo:GO_0097392 a rdfs:Class ;
  rdfs:label "chemokine (C-X-C motif) ligand 16 production" ;
  rdfs:comment "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0001618 a rdfs:Class ;
  rdfs:label "average depth of sequence coverage"@en ;
  rdfs:comment "An average value of the depth of sequence coverage based both on external (e.g. Cot-based size estimates) and internal (average coverage in the assembly) measures of genome size."@en ;
  rdfs:subClassOf obo:OBI_0000679 .

obo:OBI_0000237 a rdfs:Class ;
  rdfs:label "antigen role"@en ;
  rdfs:comment "A role of a material entity that is being recognized in whole or in part by receptors of the immune system such as antibodies or T cell receptors."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001629 a rdfs:Class ;
  rdfs:label "grant identifier"@en ;
  rdfs:comment "A CRID symbol used to identify a grant."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0002475 a rdfs:Class ;
  rdfs:label "number of PCR cycles during library construction"@en ;
  rdfs:comment "A data item that is the number of PCR cycles used during the construction of a sequencing library."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000841 a rdfs:Class ;
  rdfs:label "subject agrees they understand informed consent document" ;
  rdfs:comment "A planned process in which a subject receives an informed consent document and agrees that they have understood it."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001965 a rdfs:Class ;
  rdfs:label "decision analysis study design" ;
  rdfs:comment "a study design that has a decision analysis objective specification as part"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:IAO_0000180 a rdfs:Class ;
  rdfs:label "heatmap"@en ;
  rdfs:comment """A heatmap is a report graph which is a graphical representation of data
where the values taken by a variable(s) are shown as colors in a
two-dimensional map."""@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:CHEBI_6495 a rdfs:Class ;
  rdfs:label "lipoprotein" ;
  rdfs:comment "A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001051 a rdfs:Class ;
  rdfs:label "DNA extract" ;
  rdfs:comment "The output of an extraction process in which DNA molecules are purified in order to exclude DNA from organellas."@en ;
  rdfs:subClassOf obo:OBI_0001010 .

obo:OBI_0001778 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-X-C motif) ligand 16 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-X-C motif) ligand 16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002955 a rdfs:Class ;
  rdfs:label "mass spectrometry-based protein state assay" ;
  rdfs:comment "A type of protein state assay that employs mass spectrometry to measure levels of proteins in different phosphorylation states."@en ;
  rdfs:subClassOf obo:OBI_0002953 .

obo:OBI_0000394 a rdfs:Class ;
  rdfs:label "blot module" ;
  rdfs:comment "A blot module is a device which has the function to conatin and facilitate the material transfer process blotting to be realised"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002608 a rdfs:Class ;
  rdfs:label "oropharyngeal swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of a oropharynx."@en ;
  rdfs:subClassOf obo:OBI_0002599 , obo:OBI_2000006 .

obo:OBI_0003109 a rdfs:Class ;
  rdfs:label "obsolete single-nucleus RNA sequencing assay" ;
  rdfs:comment "A RNA-seq assay that is used for profiling gene expression in individual nuclei with optimized next generation sequencing (NGS) technologies. This allows the RNA-seq profiling of cell types that are more vulnerable to the tissue dissociation process, and that are therefore underrepresented in the final data set in single cell sequencing."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000401 a rdfs:Class ;
  rdfs:label "environment control function"@en ;
  rdfs:comment "An environmental control function is a function that regulates a contained environment within specified parameter ranges. For example the control of light exposure, humidity and temperature."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0200005 a rdfs:Class ;
  rdfs:label "feature extraction objective"@en ;
  rdfs:comment "A feature extraction objective is a data transformation objective where the aim of the data transformation is to generate quantified values from a scanned image."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0001091 a rdfs:Class ;
  rdfs:label "mechanical balance" ;
  rdfs:comment "A balance that is used to compare the weights of two bodies, to determine the difference in mass (or weight)."@en ;
  rdfs:subClassOf obo:OBI_0001135 .

obo:OBI_0000471 a rdfs:Class ;
  rdfs:label "study design execution" ;
  rdfs:comment "a planned process that carries out a study design"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003159 a rdfs:Class ;
  rdfs:label "low-density lipoprotein cholesterol concentration assay" ;
  rdfs:comment "A low-density lipoprotein cholesterol assay that measures the concentration of low-density lipoprotein cholesterol in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100032 .

obo:OBI_0003093 a rdfs:Class ;
  rdfs:label "co-detection by indexing assay" ;
  rdfs:comment "A multiplexed fluorescent antibody imaging assay that involves a highly multiplexed analysis of up to 40 proteins in a tissue using cyclic detection of DNA-indexed antibody panels."@en ;
  rdfs:subClassOf obo:OBI_0003091 .

obo:OBI_0002448 a rdfs:Class ;
  rdfs:label "differential screening hybridization" ;
  rdfs:comment "An artificially induced nucleic acid hybridization that is performed to identify differentially expressed genes through hybridization of cDNA probes."@en ;
  rdfs:subClassOf obo:OBI_0000253 .

obo:BFO_0000016 a rdfs:Class ;
  rdfs:label "disposition"@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:OBI_0000929 a rdfs:Class ;
  rdfs:label "obsolete_training service provider role" ;
  rdfs:comment "a service provider role which is realized by a servicer provider organization performing some training"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003236 a rdfs:Class ;
  rdfs:label "milk assay" ;
  rdfs:comment "An assay that has a milk specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002488 a rdfs:Class ;
  rdfs:label "pipette" ;
  rdfs:comment "A device that is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001673 a rdfs:Class ;
  rdfs:label "nano-cap analysis of gene expression assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that is performed using a very low amount (nanogram scale) of mRNA samples using Cap analysis gene expression (CAGE)."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0001536 a rdfs:Class ;
  rdfs:label "equilibrium dissociation constant (KD)" ;
  rdfs:comment "A binding constant defined as the ratio of kon over koff (on-rate of binding divided by off-rate)"@en ;
  rdfs:subClassOf obo:OBI_0001144 .

obo:OBI_0001835 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-18 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-18 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001380 , obo:OBI_0003115 .

obo:OBI_0003189 a rdfs:Class ;
  rdfs:label "mean cell volume assay" ;
  rdfs:comment "An erythrocyte assay that measures the average volume of erythrocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003190 .

obo:OBI_1110162 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-17 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001295 .

obo:OBI_0000431 a rdfs:Class ;
  rdfs:label "injection into organ section"@en ;
  rdfs:comment "A process in which an input substance is injected into a organ section."@en ;
  rdfs:subClassOf obo:OBI_0000426 .

obo:OBI_0100067 a rdfs:Class ;
  rdfs:label "bronchial alveolar lavage" ;
  rdfs:comment "Group of biomaterials present in the bronchial aveolar space of an organism which are collected through lavage including the reagents used to for the lavage process, organisms, cells, and cellular secretions present in the bronchial aveolar space."@en ;
  rdfs:subClassOf obo:OBI_0003666 .

obo:OBI_0001994 a rdfs:Class ;
  rdfs:label "assay measuring the MHC ligand binding on rate [kon] of a MHC:ligand complex" ;
  rdfs:comment "A MHC binding constant determination assay measuring binding on rate (kon)."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001553 .

obo:OBI_2100312 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:UBERON_0007650 a rdfs:Class ;
  rdfs:label "esophagogastric junction" ;
  rdfs:comment "The junction between the esophagus and the stomach epithelium." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0000704 a rdfs:Class ;
  rdfs:label "decision tree induction objective" ;
  rdfs:comment "A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:UBERON_0001637 a rdfs:Class ;
  rdfs:label "artery" ;
  rdfs:comment "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." ;
  rdfs:subClassOf obo:UBERON_0001981 .

obo:OBI_2100007 a rdfs:Class ;
  rdfs:label "eosinophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of eosinophils"@en ;
  rdfs:subClassOf obo:OBI_0003023 .

obo:UBERON_0000165 a rdfs:Class ;
  rdfs:label "mouth" ;
  rdfs:comment "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:CHEBI_23995 a rdfs:Class ;
  rdfs:label "N-ethyl-N-nitrosourea" ;
  rdfs:comment "A member of the class of <em>N</em>-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:CHEBI_59424 a rdfs:Class ;
  rdfs:label "bromophenol blue" ;
  rdfs:comment "3<em>H</em>-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002515 a rdfs:Class ;
  rdfs:label "pleural fluid specimen" ;
  rdfs:comment "A specimen that is derived from pleural fluid."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0001588 a rdfs:Class ;
  rdfs:label "binding" ;
  rdfs:comment "The process of material entities forming complexes."@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001954 a rdfs:Class ;
  rdfs:label "ChIP assay" ;
  rdfs:comment "An assay in which portions of chromatin, the ordered and organized complex of DNA and its interaction partners that make up a chormosome, is extracted and purified by immunoprecipitation with antibodies or tags, and subsequently analyzed"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001045 a rdfs:Class ;
  rdfs:label "capillary blotter" ;
  rdfs:comment "A device that is used to transfer nucleic acids from agarose gels onto a membrane, based on the movement of buffer from a reservoir through the gel and the blotting membrane to a stack of dry blotting paper by capillary force. The molecules are carried to the blotting membrane on which they are adsorbed."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002016 a rdfs:Class ;
  rdfs:label "histone modification identification by ChIP-chip assay" ;
  rdfs:comment "An epigenetic modification assay that identifies regions containing specific histones and their modifications using ChIP-chip techniques."@en ;
  rdfs:subClassOf obo:OBI_0001248 , obo:OBI_0002020 .

obo:OBI_0001529 a rdfs:Class ;
  rdfs:label "data analysis service" ;
  rdfs:comment "A service in which a service consumer provides some input data and a service provider transforms, models, or interprets the input data and returns this generated data as output."@en ;
  rdfs:subClassOf obo:OBI_0001530 .

obo:CHEBI_15422 a rdfs:Class ;
  rdfs:label "ATP" ;
  rdfs:comment "An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:IAO_0000030 a rdfs:Class ;
  rdfs:label "information content entity"@en ;
  rdfs:comment "A generically dependent continuant that is about some thing."@en .

obo:OBI_0003516 a rdfs:Class ;
  rdfs:label "position sense assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to sense the position of a finger or toe that has been manipulated by minimal random movements."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0003539 a rdfs:Class ;
  rdfs:label "deep tendon reflex assessment of the brachioradialis" ;
  rdfs:comment "A deep tendon reflex assessment of an individual's reaction to stimulus applied to a brachioradialis."@en ;
  rdfs:subClassOf obo:OBI_0003517 .

obo:PATO_0000025 a rdfs:Class ;
  rdfs:label "composition" ;
  rdfs:comment "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." ;
  rdfs:subClassOf obo:PATO_0000141 .

obo:OBI_0001437 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects chemokine (C-X-C motif) ligand 9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001459 .

obo:OBI_0200089 a rdfs:Class ;
  rdfs:label "multiple testing correction method"@en ;
  rdfs:comment "A multiple testing correction method is a hypothesis test performed simultaneously on M > 1 hypotheses.  Multiple testing procedures produce a set of rejected hypotheses that is an estimate for the set of false null hypotheses while controlling for a suitably define Type I error rate"@en ;
  rdfs:subClassOf obo:OBI_0000668 .

obo:OBI_0002179 a rdfs:Class ;
  rdfs:label "cell-attached patch clamp assay" ;
  rdfs:comment "A patch-clamp assay where the electrode is left in place on the cell, and the membrane patch has been left intact been perforated. This maintains the separation of the interior of the pipette to the intracellular space of the cell. Measurements made with this technique involve recording currents through multiple channels simultaneously, over the membrane of the entire cell."@en ;
  rdfs:subClassOf obo:OBI_0002177 .

obo:OBI_0003145 a rdfs:Class ;
  rdfs:label "assay measuring quantitative binding of a MHC:ligand complex" ;
  rdfs:comment "An assay that detects the binding of a MHC molecule with a ligand, and produces a quantitative measurement of the binding as an output."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110126 .

obo:OBI_0000341 a rdfs:Class ;
  rdfs:label "histological sample preparation"@en ;
  rdfs:comment "histological sample preparation is the preparation of an input tissue via slicing and labeling to make tissue microstructure of interest visible in a future histology assay"@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:OBI_0000715 a rdfs:Class ;
  rdfs:label "animal care protocol" ;
  rdfs:comment "An animal care protocol is a protocol which specifies the environment in which animals are being kept in captivity for research purposes"@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:OBI_1110173 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001445 .

obo:OBI_0003829 a rdfs:Class ;
  rdfs:label "luminescence detection assay" ;
  rdfs:comment "An assay that measures the luminescence of the evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0070358 a rdfs:Class ;
  rdfs:label "actin polymerization-dependent cell motility" ;
  rdfs:comment "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001282 a rdfs:Class ;
  rdfs:label "translation profiling assay" ;
  rdfs:comment "An assay in which surface-bound, translationally competent ribosome complexes are used to generate a translation profile for mRNA, which mRNA may be a single molecular species, or a combination of species, including complex mixtures such as those found in the set of mRNAs isolated from a cell or tissue. One or more components of the surface-bound ribosome complex may be labeled at specific positions to permit analysis of multiple or single molecules for determination of ribosomal conformational changes and translation kinetics. Translation profiles are used as the basis for comparison of an mRNA or set of mRNA species. The translation profile can be used to determine such characteristics as kinetics of initiation, kinetic of elongation, identity of the polypeptide product, and the like. Analysis of translation profiles may be used to determine differential gene expression, optimization of mRNA sequences for expression, screening drug candidates for an effect on translation."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002131 a rdfs:Class ;
  rdfs:label "Illumina Infinium MethylationEPIC v1.0 BeadChip" ;
  rdfs:comment "An Illumina methylation BeadChip which is an array that interrogates ~ 850,000 methylation sites per sample at single-nucleotide resolution."@en ;
  rdfs:subClassOf obo:OBI_0001870 .

obo:OBI_0000852 a rdfs:Class ;
  rdfs:label "record of missing knowledge" ;
  rdfs:comment "An information content entity created to indicate that information about something is not available to the person recording it."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_1110154 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-5 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-5 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001230 .

obo:OBI_0002035 a rdfs:Class ;
  rdfs:label "peptide mass fingerprinting assay" ;
  rdfs:comment "A mass spectrometry assay that measures the absolute mass of the cleaved peptides derived from an unknown protein of interest. These masses are then compared to values for known protein sequences to identify the unknown protein."@en ;
  rdfs:subClassOf obo:OBI_0000470 .

obo:OBI_0002534 a rdfs:Class ;
  rdfs:label "lung specimen" ;
  rdfs:comment "A specimen that is derived from lung."@en ;
  rdfs:subClassOf obo:OBI_0002783 .

obo:OBI_0003209 a rdfs:Class ;
  rdfs:label "luteinizing hormone concentration assay" ;
  rdfs:comment "A luteinizing hormone assay that measures the concentration of luteinizing hormone in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003208 .

obo:PATO_0001343 a rdfs:Class ;
  rdfs:label "Schizosaccharomyces pombe mating type" ;
  rdfs:comment "A S. pombe mating type determined by the gene configuration on the mat1 locus." ;
  rdfs:subClassOf obo:PATO_0001337 .

obo:OBI_0001583 a rdfs:Class ;
  rdfs:label "half life of binding datum" ;
  rdfs:comment "A half life datum of the time it takes for 50% of bound complexes in an ensemble to disassociate in absence of re-association."@en ;
  rdfs:subClassOf obo:OBI_0001144 , obo:OBI_0001171 .

obo:OBI_0003240 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a cerebrospinal fluid specimen."@en ;
  rdfs:subClassOf obo:OBI_0003232 , obo:OBI_0003498 .

obo:OBI_2100362 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood neutrophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of neutrophils in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003022 , obo:OBI_0003040 .

obo:NCBITaxon_2559587 a rdfs:Class ;
  rdfs:label "Riboviria" ;
  rdfs:subClassOf obo:NCBITaxon_10239 .

obo:OBI_0000370 a rdfs:Class ;
  rdfs:label "contain function"@en ;
  rdfs:comment "A contain function is a function to constrain a material entities location in space"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0001846 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-15 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-15 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001292 , obo:OBI_0600031 .

obo:UBERON_0001090 a rdfs:Class ;
  rdfs:label "synovial fluid" ;
  rdfs:comment "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0000952 a rdfs:Class ;
  rdfs:label "oral administration" ;
  rdfs:comment "An administering substance in vivo into the mouth of an organism"@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0000420 a rdfs:Class ;
  rdfs:label "obsolete_trypsinized material" ;
  rdfs:comment "A material entity that has undergone a process of digestion with trypsin"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:GO_0032604 a rdfs:Class ;
  rdfs:label "granulocyte macrophage colony-stimulating factor production" ;
  rdfs:comment "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:UBERON_0000466 a rdfs:Class ;
  rdfs:label "immaterial anatomical entity" ;
  rdfs:comment "Anatomical entity that has no mass." ;
  rdfs:subClassOf obo:BFO_0000141 , obo:UBERON_0001062 .

obo:OBI_0003225 a rdfs:Class ;
  rdfs:label "follicle stimulating hormone concentration assay" ;
  rdfs:comment "A follicle stimulating hormone assay that measures the concentration of follicle stimulating hormone in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003224 .

obo:OBI_0000419 a rdfs:Class ;
  rdfs:label "reverse transcriptase"@en ;
  rdfs:comment """enzyme and has_function some GO:0003964 (RNA-directed DNA polymerase
activity)"""@en ;
  rdfs:subClassOf obo:OBI_0000427 .

obo:OBI_0002919 a rdfs:Class ;
  rdfs:label "live arthropod specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process meant to collect live specimens."@en ;
  rdfs:subClassOf obo:OBI_0002913 .

obo:OBI_0002612 a rdfs:Class ;
  rdfs:label "fecal swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of a feces."@en ;
  rdfs:subClassOf obo:OBI_0002503 , obo:OBI_0002599 .

obo:OBA_2060188 a rdfs:Class ;
  rdfs:label "ankle joint functionality" ;
  rdfs:comment "The functionality of a ankle joint." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:OBI_2100373 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0003698 a rdfs:Class ;
  rdfs:label "observational clinical investigation"@en ;
  rdfs:comment "A clinical investigation that does not involve an intervention."@en ;
  rdfs:subClassOf obo:OBI_0003693 , obo:OBI_0003697 .

obo:OBI_0000725 a rdfs:Class ;
  rdfs:label "host role" ;
  rdfs:comment "host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0600064 a rdfs:Class ;
  rdfs:label "recombinant vector cloning"@en ;
  rdfs:comment "a planned process with the objective to insert genetic material into a cloning vector for future replication of the inserted material"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:PATO_0001995 a rdfs:Class ;
  rdfs:label "organismal quality" ;
  rdfs:comment "A quality that inheres in an entire organism or part of an organism." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBI_1110029 a rdfs:Class ;
  rdfs:label "C1R cell line"@en ;
  rdfs:comment "A cell line derived from human B cells. This cell line was created by EBV transformation (B-lymphoblastoid cell-line (BLCL))."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_2100338 a rdfs:Class ;
  rdfs:label "liver function venous blood bilirubin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin in venous blood as part of a liver function order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100018 .

obo:OBI_0000740 a rdfs:Class ;
  rdfs:label "material sample role" ;
  rdfs:comment "A material sample role is a specimen role borne by a material entity that is the output of a material sampling process."@en ;
  rdfs:subClassOf obo:OBI_0000112 .

obo:OBI_0003721 a rdfs:Class ;
  rdfs:label "cell based DNA damage assay" ;
  rdfs:comment "A cytometry assay that measures DNA damage in cells."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002820 a rdfs:Class ;
  rdfs:label "specimen collection swab stick" ;
  rdfs:comment "A specimen collection device which is a specimen pad attached to a long handle used to collect specimen material."@en ;
  rdfs:subClassOf obo:OBI_0002814 .

obo:OBI_0002453 a rdfs:Class ;
  rdfs:label "health status inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states one or more clinically significant bodily components, dispositions, and/or bodily processes of an entity that are inferred from relevant clinical findings or self-reported, which, if met, makes the entity suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:PATO_0000122 a rdfs:Class ;
  rdfs:label "length" ;
  rdfs:comment "A 1-D extent quality which is equal to the distance between two points." ;
  rdfs:subClassOf obo:PATO_0001708 .

obo:OBI_0001912 a rdfs:Class ;
  rdfs:label "cell freezing medium"@en ;
  rdfs:comment "A processed material that serves as a liquid vehicle for freezing cells for long term quiescent stroage, which contains chemicls needed to sustain cell viability across freeze-thaw cycles."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0002933 a rdfs:Class ;
  rdfs:label "Mosquito Magnet Pro trap" ;
  rdfs:comment "An arthropod trap that is powered by propane and is designed to emit a combination of carbon dioxide, heat, water, and oct-1-en-3-ol attractants while simultaneously using suction to trap arthropods."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_2100223 a rdfs:Class ;
  rdfs:label "venous blood GGT assay" ;
  rdfs:comment "An analyte assay that measures the abundance of GGT in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:MRO_0000994 a rdfs:Class ;
  rdfs:label "H2-Ks protein complex" ;
  rdfs:subClassOf obo:MRO_0001460 .

obo:OBI_0400042 a rdfs:Class ;
  rdfs:label "FC 500" ;
  rdfs:comment "A FC_500 is a flow_cytometer_analyser manufactured by Beckman Coulter. It features digital electronics, 488 nm and 635 nm lasers, filters and PMTs for 5 fluorescent parameters, a diode for collecting side scatter and a solid state detector for forward scatter. The FC 500 is an analyser usually used for either research or clinical applications."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0001857 a rdfs:Class ;
  rdfs:label "RNP (ribonuclear particle) immunoprecipitation high- throughput sequencing assay" ;
  rdfs:comment "An analyte assay that combines immunoprecipitation of an RNA-binding protein and RNA-seq to identify mRNAs associated with selected RNA binding proteins (RBPs)."@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0600047 .

obo:OBI_0003706 a rdfs:Class ;
  rdfs:label "study arm population"@en ;
  rdfs:comment "A population of organisms that are participants under investigation in the same study design execution."@en ;
  rdfs:subClassOf obo:OBI_0000181 .

obo:OBI_0003579 a rdfs:Class ;
  rdfs:label "bone marrow microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a bone marrow microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 .

obo:CHEBI_3098 a rdfs:Class ;
  rdfs:label "bile acid" ;
  rdfs:comment "Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2100041 a rdfs:Class ;
  rdfs:label "cytosolic creatine kinase complex, MB-type assay" ;
  rdfs:comment "An assay that measures cytosolic creatine kinase complex, MB-type"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001335 a rdfs:Class ;
  rdfs:label "microRNA profiling by array assay" ;
  rdfs:comment "An assay that analyses the microRNA component of the transcriptome using a microRNA array."@en ;
  rdfs:subClassOf obo:OBI_0001926 .

obo:OBI_0000103 a rdfs:Class ;
  rdfs:label "principal investigator role"@en ;
  rdfs:comment "a responsible party role played by a person responsible for the overall conduct of a study"@en ;
  rdfs:subClassOf obo:OBI_0000102 .

obo:OBI_0003502 a rdfs:Class ;
  rdfs:label "facial atrophy assessment" ;
  rdfs:comment "An observational assessment of the loss of facial muscle tissue due to inactivity or disease."@en ;
  rdfs:subClassOf obo:OBI_0003536 .

obo:OBI_0001152 a rdfs:Class ;
  rdfs:label "transfection"@en ;
  rdfs:comment "a genetic transformation which relies on the use of physical, electrical and chemical phenomena to introduce DNA or RNA into a cell"@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_0000941 a rdfs:Class ;
  rdfs:label "service consumer role" ;
  rdfs:comment "a role which inheres in a person who uses a service"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003167 a rdfs:Class ;
  rdfs:label "phosphate ion concentration assay" ;
  rdfs:comment "A phosphate ion assay that measures the concentration of phosphate ions in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100015 .

obo:OBI_0003477 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An in vivo assay measuring a B cell epitope specific protection from a tumor challenge after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001183 , obo:OBI_0002638 .

obo:OBI_0000557 a rdfs:Class ;
  rdfs:label "flash pump system" ;
  rdfs:comment "Any pump system used in flash column chromatography to push the solvent through the column. Better flow rates can be achieved by using a pump or by using compressed gas (e.g. air, nitrogen, or argon) to push the solvent through the column (flash column chromatography)."@en ;
  rdfs:subClassOf obo:OBI_0000589 .

obo:OBI_0003007 a rdfs:Class ;
  rdfs:label "arthropod trap containing small non-human animal bait" ;
  rdfs:comment "An arthropod trap that uses as attractant an animal that is not human and is the size of a chicken or smaller."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0002969 a rdfs:Class ;
  rdfs:label "cyclic immunofluoroescence assay" ;
  rdfs:comment "A type of microscopy assay resulting in highly multiplexed immunofluorescence imaging through sequential rounds of imaging followed by fluorophore inactivation."@en ;
  rdfs:subClassOf obo:OBI_0002119 .

obo:NCBITaxon_7742 a rdfs:Class ;
  rdfs:label "Vertebrata <vertebrates>" ;
  rdfs:subClassOf obo:NCBITaxon_33213 .

obo:OBI_0001925 a rdfs:Class ;
  rdfs:label "chromatin immunoprecipitation with exonuclease sequencing assay" ;
  rdfs:comment "A ChIP-seq assay which uses immunoprecipitation to isolate protein bound DNA followed by an exonuclease step to degrade DNA that is not protein bound to provide greater resolution of the DNA binding site"@en ;
  rdfs:subClassOf obo:OBI_0000716 .

obo:NCBITaxon_197562 a rdfs:Class ;
  rdfs:label "Pancrustacea" ;
  rdfs:subClassOf obo:NCBITaxon_6656 .

obo:OBI_0002772 a rdfs:Class ;
  rdfs:label "presence or over-threshold value specification"@en ;
  rdfs:comment """An ordinal value specification that indicates that either 
a) an analyte or mesaurand is present in an evaluant, or 
b) that the amount of analyte/measurand detected is over some predetermined threshold."""@en ;
  rdfs:subClassOf obo:OBI_0002756 .

obo:OBI_0001073 a rdfs:Class ;
  rdfs:label "microtome knife maker" ;
  rdfs:comment "A glass cutting and breaking device that is used to produce glass knives used in ultramicrotomy."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:GO_0007566 a rdfs:Class ;
  rdfs:label "embryo implantation" ;
  rdfs:comment "Attachment of the blastocyst to the uterine lining." ;
  rdfs:subClassOf obo:GO_0022414 .

obo:OBI_0002590 a rdfs:Class ;
  rdfs:label "molecular interaction identification design" ;
  rdfs:comment "A study design that investigates the features of interaction between molecules."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_1110018 a rdfs:Class ;
  rdfs:label "living in endemic area"@en ;
  rdfs:comment "a process in which a potential host organism lives in a geographic area in which an infectious agent is present to such a degree of frequency that contact is likely"@en ;
  rdfs:subClassOf obo:OBI_1110111 .

obo:OBI_2100291 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0001062 a rdfs:Class ;
  rdfs:label "densitometer" ;
  rdfs:comment "A device that measures the degree of darkness (the optical density) of a photographic or semitransparent material or of a reflecting surface."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0000233 a rdfs:Class ;
  rdfs:label "obsolete_defined_material" ;
  rdfs:comment "Place holder class, Utility class to gather the defined classes"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000966 a rdfs:Class ;
  rdfs:label "in live organism assay" ;
  rdfs:comment "An assay in which a measurement is made by observing entities located in an organism."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002095 a rdfs:Class ;
  rdfs:label "specimen family creation"@en ;
  rdfs:comment "A material processing that has as its input a specimen and as its output a collection of specimens."@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0003642 a rdfs:Class ;
  rdfs:label "antibody purification of mouse MHC class II protein complex" ;
  rdfs:comment "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003636 , obo:OBI_0003646 .

obo:OBI_0002664 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-15 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-15 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001292 , obo:OBI_0003115 .

obo:ENVO_00010483 a rdfs:Class ;
  rdfs:label "environmental material" ;
  rdfs:comment "A material entity which other material entities in an environmental system are primarily or partially composed of."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0002471 a rdfs:Class ;
  rdfs:label "date process started"@en ;
  rdfs:comment "A data item that is the date when a process was initiated."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002652 a rdfs:Class ;
  rdfs:label "computed tomography assisted biopsy" ;
  rdfs:comment "A needle biopsy guided by real-time computed tomography (CT) scan images."@en ;
  rdfs:subClassOf obo:OBI_0002651 .

obo:OBI_0000561 a rdfs:Class ;
  rdfs:label "Bruker NMR probe" ;
  rdfs:comment "An NMR probe that is manufactured by Bruker."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_0002754 a rdfs:Class ;
  rdfs:label "cDNA library"@en ;
  rdfs:comment "A collection of DNA molecules with sequences complementary to a specified set of mRNA molecules and commonly developed by enzymatic reverse transcription."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0002508 a rdfs:Class ;
  rdfs:label "sputum specimen" ;
  rdfs:comment "A specimen that is derived from sputum."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0003137 a rdfs:Class ;
  rdfs:label "gene-trap mutagenesis" ;
  rdfs:comment "A transgenic mutagenesis that produces a mutation by introducing a construct designed to capture the expression of an endogenous gene by creating a spliced fusion transcript when inserted into the genome of an organism."@en ;
  rdfs:subClassOf obo:OBI_0003136 .

obo:OBI_2100108 a rdfs:Class ;
  rdfs:label "cardiac enzymes venous blood creatine kinase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatine kinase in venous blood as part of a cardiac enzymes order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100025 .

obo:OBI_0000546 a rdfs:Class ;
  rdfs:label "capillary pump system" ;
  rdfs:comment "A pump system optimized for capillary chromatography."@en ;
  rdfs:subClassOf obo:OBI_0000589 .

obo:UBERON_0001268 a rdfs:Class ;
  rdfs:label "peritoneal fluid" ;
  rdfs:comment "Transudate contained in the peritoneal cavity." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0002121 a rdfs:Class ;
  rdfs:label "killer cell immunoglobulin-like receptor typing assay" ;
  rdfs:comment "A genotyping assay in which the alleles of genes encoding for killer cell immunoglobulin-like receptors are determined."@en ;
  rdfs:subClassOf obo:OBI_0000435 .

obo:OBI_0002433 a rdfs:Class ;
  rdfs:label "history of sex with someone with a history of intravenous drugs exclusion criterion" ;
  rdfs:comment "An exclusion criterion defined  as whether an individual has a history of sex with someone who has used intravenous drugs in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0001324 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific tolerance induction" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that uses a tolerance induction intervention experiment."@en ;
  rdfs:subClassOf obo:OBI_0001484 , obo:OBI_0001488 .

obo:GO_0032639 a rdfs:Class ;
  rdfs:label "TRAIL production" ;
  rdfs:comment "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:IAO_8000006 a rdfs:Class ;
  rdfs:label "subset ontology module"@en ;
  rdfs:comment "An ontology module that is extracted from a main ontology module and includes only a subset of entities or axioms."@en ;
  rdfs:seeAlso <http://robot.obolibrary.org/filter> , <http://www.geneontology.org/page/go-slim-and-subset-guide> ;
  rdfs:subClassOf obo:IAO_8000000 .

obo:OBI_0003096 a rdfs:Class ;
  rdfs:label "imaging mass cytometry assay" ;
  rdfs:comment "A cytometry time of flight assay in which molecules of interest on or in cells are imaged through a system in which samples are labeled with multiple different rare-earth tagged antibodies. The sample is then ablated with a laser and the labeled material is detected by cytometry time of flight mass spectrometry."@en ;
  rdfs:subClassOf obo:OBI_0002115 .

obo:OBI_0002950 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based drug synergy assay" ;
  rdfs:comment "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures to determine if drugs applied to cells in combination have a greater effect together than the sum of their separate effects."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000937 a rdfs:Class ;
  rdfs:label "obsolete_left handedness" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:MRO_0002027 a rdfs:Class ;
  rdfs:label "H2-Kq protein complex" ;
  rdfs:subClassOf obo:MRO_0001460 .

obo:UBERON_0000996 a rdfs:Class ;
  rdfs:label "vagina" ;
  rdfs:comment "A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0302905 a rdfs:Class ;
  rdfs:label "elution"@en ;
  rdfs:comment "the process of extracting one material from another by washing with a solvent to remove adsorbed material from an adsorbent (as in washing of loaded ion-exchange resins to remove captured ions)"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_2100320 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0003434 a rdfs:Class ;
  rdfs:label "sorbitol dehydrogenase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of sorbitol dehydrogenase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0002627 a rdfs:Class ;
  rdfs:label "ribosomal RNA-depleted RNA extract" ;
  rdfs:comment "An extract of RNA which is produced through rRNA (ribosomal RNA) depletion (the removal of highly abundant rRNA species)."@en ;
  rdfs:subClassOf obo:OBI_0000880 .

obo:OBI_0200192 a rdfs:Class ;
  rdfs:label "classified data visualization" ;
  rdfs:comment "A data visualization which has input of a classified data set and produces an output of a report graph which is capable of rendering data of this type."@en ;
  rdfs:subClassOf obo:OBI_0200111 .

obo:OBI_0001084 a rdfs:Class ;
  rdfs:label "vitrification apparatus" ;
  rdfs:comment "A device that is used to effect the transition of a substance into a glass."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003321 a rdfs:Class ;
  rdfs:label "venous blood microbiology assay" ;
  rdfs:comment "A blood microbiology assay that detects a microorganism in a venous blood specimen."@en ;
  rdfs:subClassOf obo:OBI_0002649 .

obo:OBI_0001577 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific intracellular cytokine staining (ICS) IL-22 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001217 , obo:OBI_0003115 .

obo:OBI_0001056 a rdfs:Class ;
  rdfs:label "DNA synthesizer" ;
  rdfs:comment "An oligonucleotide synthesizer that is used to custom-build DNA molecules to contain a particular sequence of nucleotides."@en ;
  rdfs:subClassOf obo:OBI_0400113 .

obo:OBI_0400094 a rdfs:Class ;
  rdfs:label "sheath tank" ;
  rdfs:comment "Part of the fluidics system. The sheath tank is the vessel that holds the sheath fluid at a constant pressure, allowing for it to be pushed into the flow chamber at a constant rate. The sheath tank holds the pressurized sheath fluid."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0000554 a rdfs:Class ;
  rdfs:label "gas chromatography oven" ;
  rdfs:comment "A gas chromatography oven is an oven with a heated connection between the GC and the MS instrument in a GCMS-analysis, that keeps compounds in the gas phase as they leave the GC oven."@en ;
  rdfs:subClassOf obo:OBI_0000542 .

obo:OBI_0001756 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects chemokine (C-X-C motif) ligand 9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001459 , obo:OBI_0600031 .

obo:OBI_0001243 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects monocyte chemotactic protein-1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001465 , obo:OBI_0003115 .

obo:OBI_0000995 a rdfs:Class ;
  rdfs:label "administration of material to specimen" ;
  rdfs:comment "The directed combination of a material entity with a specimen."@en ;
  rdfs:subClassOf obo:OBI_0000652 .

obo:MRO_0001149 a rdfs:Class ;
  rdfs:label "HLA-C protein complex" ;
  rdfs:subClassOf obo:MRO_0001454 .

obo:CHEBI_42098 a rdfs:Class ;
  rdfs:label "digoxigenin" ;
  rdfs:comment "A hydroxy steroid that consists of 5β-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3β-, 12β- and 14β-positions. It has been isolated from the plant species of the genus <em>Digitalis</em>." ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:OBI_0000272 a rdfs:Class ;
  rdfs:label "protocol"@en ;
  rdfs:comment "A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:UBERON_0001488 a rdfs:Class ;
  rdfs:label "ankle joint" ;
  rdfs:comment "A joint that connects the hindlimb autopod and zeugopod skeletons." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003085 a rdfs:Class ;
  rdfs:label "laboratory postal address" ;
  rdfs:comment "A postal address used as a directive to deliver something to a laboratory."@en ;
  rdfs:subClassOf obo:IAO_0000422 .

obo:OBI_0002041 a rdfs:Class ;
  rdfs:label "self-transcribing active regulatory region sequencing assay" ;
  rdfs:comment "An assay that identifies the sequences that act as transcriptional enhancers in a direct, quantitative, and genome-wide manner from sheared genomic DNA."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0002460 a rdfs:Class ;
  rdfs:label "defined population inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that is based on fitting within the defined characteristics of a population based study design."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0000458 a rdfs:Class ;
  rdfs:label "manufacturing objective"@en ;
  rdfs:comment "is the objective to manufacture a material of a certain function (device)"@en ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:OBI_2100186 a rdfs:Class ;
  rdfs:label "arterial blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0001604 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring 50% dissociation of binding temperature [Tm] of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures the 50% dissociation of binding temperature of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0003145 .

obo:OBI_0002653 a rdfs:Class ;
  rdfs:label "ultrasound-guided needle biopsy" ;
  rdfs:comment "A needle biopsy guided by ultrasound visualization."@en ;
  rdfs:subClassOf obo:OBI_0002651 .

obo:OBI_2100272 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0302837 a rdfs:Class ;
  rdfs:label "decapitated organism"@en ;
  rdfs:comment "decapitated organism is an organism which has had it's head removed"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_2100153 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_0003643 a rdfs:Class ;
  rdfs:label "antibody purification of H2-IA protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IA protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003642 .

obo:OBI_0001120 a rdfs:Class ;
  rdfs:label "portable fluorometer" ;
  rdfs:comment "A compact fluorometer that can be carried or moved with ease."@en ;
  rdfs:subClassOf obo:OBI_0400143 .

obo:OBI_0002713 a rdfs:Class ;
  rdfs:label "WHO larvicide diagnostic assay" ;
  rdfs:comment "A direct insecticide resistance diagnostic assay tests survival of larvae in a medium supplemented with insecticide."@en ;
  rdfs:subClassOf obo:OBI_0002707 .

obo:UBERON_0007106 a rdfs:Class ;
  rdfs:label "chorionic villus" ;
  rdfs:comment "One of the minute vascular projections of the fetal chorion that combines with maternal uterine tissue to form the placenta." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_0003772 a rdfs:Class ;
  rdfs:label "neurite count assay" ;
  rdfs:comment "A cytometry assay that measures the number of neurites in a cultured specimen."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0200101 a rdfs:Class ;
  rdfs:label "linear discriminant functional analysis"@en ;
  rdfs:comment "Linear discriminant functional analysis (LDFA) is a multivariate technique used in special applications where there are several intact groups (random assignment may be impossible) and they have been measured on several independent measures. Thus, you will want to describe how these groups differ on the basis of these measures. In this case, classification and prediction is the main objective."@en ;
  rdfs:subClassOf obo:OBI_0000663 , obo:OBI_0200106 , obo:OBI_0200175 .

obo:OBI_0002583 a rdfs:Class ;
  rdfs:label "DNA methylation profiling data" ;
  rdfs:comment "The results of a DNA methylation profiling assay"@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0002089 a rdfs:Class ;
  rdfs:label "container with environmental control" ;
  rdfs:comment "A container with an environmental control function."@en ;
  rdfs:subClassOf obo:OBI_0000967 , obo:OBI_0001034 .

obo:OBI_0001704 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific activation of additional immune response in vitro" ;
  rdfs:comment "A B cell epitope dependent biological activity determination assay that detects secondary in vitro activity."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001706 .

obo:NCBITaxon_2732514 a rdfs:Class ;
  rdfs:label "Revtraviricetes" ;
  rdfs:subClassOf obo:NCBITaxon_2559587 .

obo:PR_000050343 a rdfs:Class ;
  rdfs:label "alkaline phosphatase (human)" ;
  rdfs:comment "A protein that is a translation product of any of the following alkaline phosphatase genes in human: ALPG (encoding the germinal form; GCAP), ALPP (encoding the placental form; PLAP), ALPI (encoding the intestinal form; IAP), and ALPL (encoding the tissue non-specific form; TNAP)." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003148 a rdfs:Class ;
  rdfs:label "albumin concentration assay" ;
  rdfs:comment "An albumin assay that measures the concentration of albumin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100022 .

obo:OBI_0003359 a rdfs:Class ;
  rdfs:label "deterministic brain region atlas image data set" ;
  rdfs:comment "A brain atlas consisting of discrete integer values where a value X denotes a voxel is part of some brain component Y."@en ;
  rdfs:subClassOf obo:OBI_0003357 .

obo:OBI_0001875 a rdfs:Class ;
  rdfs:label "cultured immune cell population"@en ;
  rdfs:comment "a cultured cell population comprised of a single type of immune system cell"@en ;
  rdfs:subClassOf obo:OBI_0100060 .

obo:OBI_0002545 a rdfs:Class ;
  rdfs:label "ileum specimen" ;
  rdfs:comment "A specimen that is derived from ileum."@en ;
  rdfs:subClassOf obo:OBI_0003483 .

obo:OBI_0003375 a rdfs:Class ;
  rdfs:label "patch-seq assay" ;
  rdfs:comment "An assay that combines electrophysiological, transcriptomic, and morphological characterization of individual neurons. In this approach, patch-clamp is used to generate an electrophysiological recording of the neuron, then the neuron's cytoplasm and/or nucleus is collected and processed for RNAseq, and finally the cell is simultaneously filled with a dye that allows for subsequent morphological reconstruction."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0400143 a rdfs:Class ;
  rdfs:label "fluorometer" ;
  rdfs:comment "A fluorometer is an instrument for the detection and measurement of parameters of fluoresence, which in turn are used to identify the presence and amount of specific molecules in the sample."@en ;
  rdfs:subClassOf obo:OBI_0400115 .

obo:UBERON_0000477 a rdfs:Class ;
  rdfs:label "anatomical cluster" ;
  rdfs:comment "Anatomical group whose component anatomical structures lie in close proximity to each other." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_0600003 a rdfs:Class ;
  rdfs:label "obsolete performing a clinical assessment" ;
  rdfs:comment "A protocol application during which a series of tests are made of a patient leading to determination of disease state, or condition."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003693 a rdfs:Class ;
  rdfs:label "observational investigation"@en ;
  rdfs:comment "An investigation in which subjects are monitored in the absence of any active intervention by experimentalists."@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_0000946 a rdfs:Class ;
  rdfs:label "sterilization function" ;
  rdfs:comment "a function to remove viable organisms from an input material"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_2000008 a rdfs:Class ;
  rdfs:label "semen specimen" ;
  rdfs:comment "A specimen that is derived from some semen"@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_2100055 a rdfs:Class ;
  rdfs:label "panel5 venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a panel5 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0003332 a rdfs:Class ;
  rdfs:label "magnetic resonance pulse sequence protocol"@en ;
  rdfs:comment "The NMR/MRI machine protocol about the radiofrequency pulse sequence."@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:OBI_0000827 a rdfs:Class ;
  rdfs:label "pill" ;
  rdfs:comment "A dose of medicine or placebo in the form of a small pellet."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0000498 a rdfs:Class ;
  rdfs:label "NMR tube washing system" ;
  rdfs:comment "An automatic cleaning system for NMR tubes that removes previous probe and sample residues in order to allow for tube recycling."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:PR_000004580 a rdfs:Class ;
  rdfs:label "beta-2-microglobulin" ;
  rdfs:comment "A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0600021 a rdfs:Class ;
  rdfs:label "cell fixation"@en ;
  rdfs:comment "a protocol application to preserve defined  qualities of cells or tissues (sample) which may otherwise change over time"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000673 a rdfs:Class ;
  rdfs:label "statistical hypothesis test"@en ;
  rdfs:comment "A statistical hypothesis test data transformation is a data transformation that has objective statistical hypothesis test."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001306 a rdfs:Class ;
  rdfs:label "RNA stability design" ;
  rdfs:comment "A study design that examines the stability and/or decay of RNA transcripts."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:NCBITaxon_11676 a rdfs:Class ;
  rdfs:label "Human immunodeficiency virus 1" ;
  rdfs:subClassOf obo:NCBITaxon_11646 .

obo:OBI_0001785 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects macrophage inflammatory protein-1 gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001456 .

obo:OBI_0000967 a rdfs:Class ;
  rdfs:label "container" ;
  rdfs:comment "A device that can be used to restrict the location of material entities over time"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002551 a rdfs:Class ;
  rdfs:label "suprapubic skin specimen" ;
  rdfs:comment "A specimen that is derived from suprapubic skin."@en ;
  rdfs:subClassOf obo:OBI_0002526 .

obo:OBI_0002947 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based cell proliferation assay" ;
  rdfs:comment "A type of cell proliferation assay in which fluorescent dyes are ued to label and detect proteins or structures that can be used to count cells."@en ;
  rdfs:subClassOf obo:OBI_0000891 .

obo:OBI_0002601 a rdfs:Class ;
  rdfs:label "demultiplexed sequence data" ;
  rdfs:comment "Sequence data in which an identifier subsequence has been used to categorize each reads by source."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001480 a rdfs:Class ;
  rdfs:label "phage display library panning" ;
  rdfs:comment "Phage display library panning is a process in which a diverse collection of phages encoding peptides or proteins are screened and the ones encoding active peptides/proteins are selected in an iterative process similar to natural selection."@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0001685 a rdfs:Class ;
  rdfs:label "amplification of intermethylated sites assay" ;
  rdfs:comment "An assay that estimates genome-wide DNA methylation and measures methylation of DNA sequences. AIMS is based on the differential enzymatic digestion of genomic DNA with methylation-sensitive and methylation-insensitive isoschizomers followed by restrained PCR amplification of methylated sequences."@en ;
  rdfs:subClassOf obo:OBI_0000634 .

obo:OBI_0000054 a rdfs:Class ;
  rdfs:label "ratio of collected to emitted light"@en ;
  rdfs:comment "A measurement datum measuring the amount of light collected s compared to the total amount of emitted light in the detector component of a flow cytometer instrument. The datum has a qualitative role"@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0002507 a rdfs:Class ;
  rdfs:label "saliva specimen" ;
  rdfs:comment "A specimen that is derived from saliva."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0000338 a rdfs:Class ;
  rdfs:label "drawing a conclusion based on data"@en ;
  rdfs:comment "A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002459 a rdfs:Class ;
  rdfs:label "genotype phasing by Hi-C assay" ;
  rdfs:comment "A genotyping assay in which carbon-copy chromosome conformation is used to detect polymorphism in DNA samples."@en ;
  rdfs:subClassOf obo:OBI_0000435 .

obo:OBI_0002802 a rdfs:Class ;
  rdfs:label "laboratory coat" ;
  rdfs:comment "A personal protective clothing item which is an overcoat worn by medical or laboratory professionals."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_0002931 a rdfs:Class ;
  rdfs:label "light trap for indoor use" ;
  rdfs:comment "A light trap designed to be placed inside a building."@en ;
  rdfs:subClassOf obo:OBI_0002930 .

obo:OBI_0003486 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-25 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-25 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0003484 .

obo:UO_0000109 a rdfs:Class ;
  rdfs:label "pressure unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:OBI_0000654 a rdfs:Class ;
  rdfs:label "device setting" ;
  rdfs:comment "a quality inheres_in some device and is concretization of some (device_setting_specification and is_about a quality of the device"@en ;
  rdfs:subClassOf obo:COB_0000502 .

obo:OBI_0001726 a rdfs:Class ;
  rdfs:label "quenching assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A fluorescence quenching assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001635 , obo:OBI_0001703 .

obo:OBI_2100164 a rdfs:Class ;
  rdfs:label "venous blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0002518 a rdfs:Class ;
  rdfs:label "prostate gland specimen" ;
  rdfs:comment "A specimen that is derived from prostate gland."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:GO_0042571 a rdfs:Class ;
  rdfs:label "immunoglobulin complex, circulating" ;
  rdfs:comment "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." ;
  rdfs:subClassOf obo:GO_0019814 , obo:OBI_1110022 .

obo:OBI_0600022 a rdfs:Class ;
  rdfs:label "excision"@en ;
  rdfs:comment "the use physical means to remove a portion of a substance from the rest"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0002522 a rdfs:Class ;
  rdfs:label "adrenal gland specimen" ;
  rdfs:comment "A specimen that is derived from adrenal gland."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:IAO_0000414 a rdfs:Class ;
  rdfs:label "mass measurement datum"@en ;
  rdfs:comment "A scalar measurement datum that is the result of measurement of mass quality"@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0000666 a rdfs:Class ;
  rdfs:label "background correction data transformation"@en ;
  rdfs:comment "A background correction data transformation (sometimes called supervised classification) is a data transformation that has the objective background correction."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0200016 a rdfs:Class ;
  rdfs:label "sine transformation"@en ;
  rdfs:comment "A sine transformation is a data transformation which consists in applying the sine function to a (one dimensional) real number input. The sine function is one of the basic trigonometric functions and a definition is provided, e.g., at http://mathworld.wolfram.com/Sine.html."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0200049 a rdfs:Class ;
  rdfs:label "Benjamini and Yekutieli false discovery rate correction method"@en ;
  rdfs:comment "A data transformation in which the Benjamini and Yekutieli method is applied with the aim of correcting false discovery rate"@en ;
  rdfs:subClassOf obo:OBI_0200163 .

obo:OBI_0001030 a rdfs:Class ;
  rdfs:label "RNASE T1 structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale uses RNAse T1 as reagent and enzymatic probe."@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:OBI_0400056 a rdfs:Class ;
  rdfs:label "Influx Cell Sorter" ;
  rdfs:comment "A Influx Cell Sorter is a flow_cytometer_sorter manufactured by Cytopeia. It is a digital machine, with these laser options: Coherent 70, 90, 300 series water cooled lasers, solid state UV 355nm, Violet 408nm, Violet-Blue 479nm, Blue-488nm, Green-531nm, Red-635nm, Red-647nm. The sorting is multi-way, index, and proportional sorting. Filters and PMTs are used for all parameters (including forward light scatter), and up to 12 PMTs can be included. The Influx cell sorter can be used to measure, sort, and collect ndividual cells."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0001149 a rdfs:Class ;
  rdfs:label "gene knock in"@en ;
  rdfs:comment "a genetic transformation that involves the insertion of a protein coding cDNA sequence at a particular locus in an organism's chromosome. Typically, this is done in mice since the technology for this process is more refined, and because mouse embryonic stem cells are easily manipulated. The difference between knock-in technology and transgenic technology is that a knock-in involves a gene inserted into a specific locus, and is a \"targeted\" insertion."@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_0003710 a rdfs:Class ;
  rdfs:label "assessment of startle response in an organism" ;
  rdfs:comment "A nervous system functionality assessment of auditory startle response in an organism in an anechoic chamber by exposing to sound."@en ;
  rdfs:subClassOf obo:OBI_0003533 .

obo:OBI_2100387 a rdfs:Class ;
  rdfs:label "blood gas arterial blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0001275 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "A process of interleukin-16 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032619 , obo:OBI_0001193 .

obo:PATO_0000070 a rdfs:Class ;
  rdfs:label "amount" ;
  rdfs:comment "The number of entities of this type that are part of the whole organism." ;
  rdfs:subClassOf obo:PATO_0103000 .

obo:OBI_0002814 a rdfs:Class ;
  rdfs:label "specimen collection device" ;
  rdfs:comment "A device used to collect a specimen."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000482 a rdfs:Class ;
  rdfs:label "normal phase column" ;
  rdfs:comment "A normal phase column is a chromatography column in which the stationary phase is more polar than the mobile phase. Its counterpart is the reversed phase column."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:ENVO_02500000 a rdfs:Class ;
  rdfs:label "environmental system process"@en ;
  rdfs:comment "A process in which includes the components of an environmental system as participants." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:PR_000014060 a rdfs:Class ;
  rdfs:label "ribonuclease T2" ;
  rdfs:comment "A protein that is a translation product of the human RNASET2 gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0001791 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific lymphotoxin A production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects lymphotoxin A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001272 , obo:OBI_0001327 , obo:OBI_0600031 .

obo:OBI_0200091 a rdfs:Class ;
  rdfs:label "inter-rater reliability objective"@en ;
  rdfs:comment "a data transformation objective of determining the concordance or agreement between human judges."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0001774 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 21 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-C motif) ligand 21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:PATO_0070044 a rdfs:Class ;
  rdfs:label "anatomical structure quality" ;
  rdfs:comment "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:GO_0003824 a rdfs:Class ;
  rdfs:label "catalytic activity" ;
  rdfs:comment "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." ;
  rdfs:subClassOf obo:GO_0003674 .

obo:OBI_0003224 a rdfs:Class ;
  rdfs:label "follicle stimulating hormone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of follicle stimulating hormone"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000017 a rdfs:Class ;
  rdfs:label "regulatory role"@en ;
  rdfs:comment "a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0005246 a rdfs:Class ;
  rdfs:label "injection function" ;
  rdfs:comment "The function of a device realized when administering a substance in vivo, applied particularly to the forcible insertion of a liquid or gas by means of a syringe, pump, etc."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0003912 a rdfs:Class ;
  rdfs:label "in vitro CRISPR screen using single-cell ATAC-seq" ;
  rdfs:comment "An in vitro CRISPR screen assay that uses single-cell ATAC-Seq to detect induced changes in chromatin accessibility"@en ;
  rdfs:subClassOf obo:OBI_0003659 .

obo:OBI_0002958 a rdfs:Class ;
  rdfs:label "SWATH-MS protein profiling assay" ;
  rdfs:comment "A type of mass spectrometry assay using a data-independent acquisition method to identify target peptides."@en ;
  rdfs:subClassOf obo:OBI_0000615 .

obo:OBI_0302731 a rdfs:Class ;
  rdfs:label "buffer role"@en ;
  rdfs:comment "a role which inheres in some molecular entity realized during the process of buffering"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001077 a rdfs:Class ;
  rdfs:label "small-animal image acquisition device" ;
  rdfs:comment "A device that is used to image small laboratory animals (e.g., rats and mice) in vivo."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0003590 a rdfs:Class ;
  rdfs:label "serum anti-cytomegalovirus antibody level assay" ;
  rdfs:comment "A CMV antibody assay that has serum as an input."@en ;
  rdfs:subClassOf obo:OBI_0002154 , obo:OBI_0003040 .

obo:PR_000025402 a rdfs:Class ;
  rdfs:label "T cell receptor co-receptor CD8" ;
  rdfs:comment "A protein-containing complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0400169 a rdfs:Class ;
  rdfs:label "microscope" ;
  rdfs:comment "A microscope is an instrument which magnifies the view on objects (too small to be viewed by the naked eye) under increased resolution. A microscope can be an optical instrument but also and electronic instrument. There are various kind of optical microscopes, e.g confocal microscope, epifluoresence microscope)"@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0002493 a rdfs:Class ;
  rdfs:label "control role in case-control study"@en ;
  rdfs:comment "A role that is borne by a case-control study design participant under investigation that is not associated with the outcome mentioned in the study design."@en ;
  rdfs:subClassOf obo:OBI_0000097 .

obo:OBI_0000221 a rdfs:Class ;
  rdfs:label "vital dye role"@en ;
  rdfs:comment "A dye role that is realized when used to detect live cells in an experiment"@en ;
  rdfs:subClassOf obo:OBI_0000250 .

obo:OBI_0001414 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:GO_0016788 a rdfs:Class ;
  rdfs:label "hydrolase activity, acting on ester bonds" ;
  rdfs:comment "Catalysis of the hydrolysis of any ester bond." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0000288 a rdfs:Class ;
  rdfs:label "protein-protein interaction detection assay" ;
  rdfs:comment "An assay that determines interactions between proteins, such as protein-protein binding."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:NCBITaxon_9606 a rdfs:Class ;
  rdfs:label "Homo sapiens" ;
  rdfs:subClassOf obo:NCBITaxon_314146 .

obo:OBI_0002027 a rdfs:Class ;
  rdfs:label "Illumina Genome Analyzer IIe" ;
  rdfs:comment "An Illumina Genome Analyzer II which is manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology. The Genome Analyzer IIe makes industry-leading next-generation sequencing technology accessible to more laboratories."@en ;
  rdfs:subClassOf obo:OBI_0000703 .

obo:OBI_2100346 a rdfs:Class ;
  rdfs:label "venous blood reticulocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of reticulocytes in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003026 , obo:OBI_0003040 .

obo:OBI_2100283 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood promyelocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of promyelocytes in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003019 , obo:OBI_0003040 .

obo:OBI_0000232 a rdfs:Class ;
  rdfs:label "hardware optimization objective"@en ;
  rdfs:comment "Hardware_optimization is a hardware_testing_objective describing a study designed to identify the best hardware."@en ;
  rdfs:subClassOf obo:OBI_0000134 .

obo:CHEBI_38559 a rdfs:Class ;
  rdfs:label "cytochrome P450" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001849 a rdfs:Class ;
  rdfs:label "structural analysis by paired-end tag sequencing assay" ;
  rdfs:comment "An assay that incorporates Paired-End Tags and sequencing technology to determine structural variants."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_1000024 a rdfs:Class ;
  rdfs:label "cell pellet"@en ;
  rdfs:comment "A material entity which results from the aggregation of cells produced by the application of centrifugal force to a liquid containing cells in suspension"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0600038 a rdfs:Class ;
  rdfs:label "addition of molecular label"@en ;
  rdfs:comment "a material processing technique intended to add a molecular label to some input material entity, to allow detection of the molecular target of this label in a detection of molecular label assay"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003310 a rdfs:Class ;
  rdfs:label "split-pool recognition of interactions and tag extension assay" ;
  rdfs:comment "A sequencing assay designed to detect multi-way interactions between nucleic acids. The procedure involves crosslinking nuclei, and then splitting the lysate among wells in a 96-well or other multi-well plate. A different barcode is ligated to the fragments in each well, and the lysates are pooled together again. This sequence of splitting, tagging, and re-combining is repeated several times so that fragments with the same sequences of barcodes represent fragments that have co-associated throughout the experiment. Finally, a sequencing library is constructed and high-throughput sequencing is performed."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:CL_0000404 a rdfs:Class ;
  rdfs:label "electrically signaling cell" ;
  rdfs:comment "A cell that initiates an electrical signal and passes that signal to another cell." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0500009 a rdfs:Class ;
  rdfs:label "loop design" ;
  rdfs:comment "A loop experiment design is where labeled extracts are compared in consecutive pairs. synonym: circular design"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:CL_0000235 a rdfs:Class ;
  rdfs:label "macrophage" ;
  rdfs:comment "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." ;
  rdfs:subClassOf obo:CL_0000842 .

obo:OBI_0600049 a rdfs:Class ;
  rdfs:label "DNA polymerase amplification"@en ;
  rdfs:comment "DNA polymerase amplification is an enzymatic amplification which uses DNA polymerase enzyme to make copies of a DNA contained in biomaterial used as input"@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBI_0000260 a rdfs:Class ;
  rdfs:label "plan"@en ;
  rdfs:comment "A plan is a realizable entity that is the inheres in a bearer who is committed to realizing it as a completely executed planned process."@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:RO_0000059 a rdf:Property ;
  rdfs:label "concretizes"@en ;
  rdfs:comment "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0200195 a rdfs:Class ;
  rdfs:label "proportional hazards model estimation" ;
  rdfs:comment "Proportional hazards model is a data transformation model to estimate the effects of different covariates influencing the times-to-failure of a system."@en ;
  rdfs:subClassOf obo:OBI_0200194 .

obo:OBI_0400121 a rdfs:Class ;
  rdfs:label "molecular crosslinker" ;
  rdfs:comment "A device that is able to chemically join two or more molecules."@en ;
  rdfs:subClassOf obo:OBI_0001032 , obo:OBI_0001034 .

obo:OBI_0000407 a rdfs:Class ;
  rdfs:label "viral RNA extraction"@en ;
  rdfs:comment "The extraction of RNA from an input material that specifically isolates viral RNA"@en ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:UBERON_0001134 a rdfs:Class ;
  rdfs:label "skeletal muscle tissue" ;
  rdfs:comment "Muscle tissue that consists primarily of skeletal muscle fibers." ;
  rdfs:subClassOf obo:UBERON_0002385 .

obo:OBI_0002197 a rdfs:Class ;
  rdfs:label "tissue section thickness"@en ;
  rdfs:comment "A length measurement datum that is the result of an assay measuring the thickness of a tissue section."@en ;
  rdfs:subClassOf obo:IAO_0000408 .

obo:OBI_0002821 a rdfs:Class ;
  rdfs:label "cotton swab" ;
  rdfs:comment "A device which is a cotton pad mounted on one or both ends of a stick."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_1110020 a rdfs:Class ;
  rdfs:label "Immunization in vitro"@en ;
  rdfs:comment "A planned process with the objective to administer an object playing the role of immunogen to a cell culture."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001771 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific vascular endothelial growth factor production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects vascular endothelial growth factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001570 , obo:OBI_0600031 .

obo:OBI_0200132 a rdfs:Class ;
  rdfs:label "node in-degree calculation"@en ;
  rdfs:comment "A node quality calculation in which an input data set describing object nodes and directional relationship edges between object nodes is used to enumerate the number of unique relationships pointing into an individual object node."@en ;
  rdfs:subClassOf obo:OBI_0200129 .

obo:OBI_0002444 a rdfs:Class ;
  rdfs:label "measurand role"@en ;
  rdfs:comment "A role borne by a material entity and realized in an assay which achieves the objective to measure the magnitude/concentration/amount of the measurand in the entity bearing evaluant role."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003472 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An in vivo assay measuring a T cell epitope specific protection from a tumor challenge after adoptive transfer of epitope specific T cells."@en ;
  rdfs:subClassOf obo:OBI_0001183 , obo:OBI_0002637 .

obo:OBI_0001521 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific granulocyte colony stimulating factor production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects granulocyte colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001600 .

obo:OBI_0000125 a rdfs:Class ;
  rdfs:label "number of lost events electronic"@en ;
  rdfs:comment "A measurement datum measuring the number of analysis events lost due to errors in data acquisition electronic coincidence in a flow cytometer instrument. The datum has a qualitative role."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0003077 a rdfs:Class ;
  rdfs:label "entomological data item" ;
  rdfs:comment "A data item that is about a collection of insects."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0600033 a rdfs:Class ;
  rdfs:label "cell permeabilization"@en ;
  rdfs:comment "A protocol application to permeabilize cell membranes, allowing molecules to more easily pass through the membrane than was possible prior to the protocol application"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:COB_0000082 a rdfs:Class ;
  rdfs:label "planned process"@en ;
  rdfs:comment "A process that is initiated by an agent who intends to carry out a plan to achieve an objective through one or more actions as described in a plan specification."@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:UBERON_0002358 a rdfs:Class ;
  rdfs:label "peritoneum" ;
  rdfs:comment "A serous membrane that lines the peritoneal cavity[VHOG,modified]." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:OBI_0003044 a rdfs:Class ;
  rdfs:label "parasite species identification by PCR assay" ;
  rdfs:comment "A parasite detection by PCR assay that identifies the species of parasite."@en ;
  rdfs:subClassOf obo:OBI_0003045 .

obo:OBI_0200013 a rdfs:Class ;
  rdfs:label "loess global transformation one-channel"@en ;
  rdfs:comment "A loess global transformation one-channel is a loess global transformation in the special case where the input is the result of an MA transformation applied to intensities from two related one-channel assays."@en ;
  rdfs:subClassOf obo:OBI_0200023 .

obo:OBI_0003227 a rdfs:Class ;
  rdfs:label "total lymphocyte percentage assay" ;
  rdfs:comment "A lymphocyte assay that measures the percentage of lymphocytes and large unstained cells in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003024 .

obo:GO_0043316 a rdfs:Class ;
  rdfs:label "cytotoxic T cell degranulation" ;
  rdfs:comment "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." ;
  rdfs:subClassOf obo:GO_0001906 .

obo:COB_0000026 a rdfs:Class ;
  rdfs:label "processed material entity"@en ;
  rdfs:comment "A material entity processed by human activity with an intent to produce it."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:CHEBI_20067 a rdfs:Class ;
  rdfs:label "3-hydroxybutyric acid" ;
  rdfs:comment "A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001823 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-C motif) ligand 21 production by T cells" ;
  rdfs:comment "A process of chemokine (C-C motif) ligand 21 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0097389 , obo:OBI_0001193 .

obo:OBI_0000043 a rdfs:Class ;
  rdfs:label "xenotransplantation"@en ;
  rdfs:comment "is the transplantation of living cells, tissues or \\norgans from one species to another such as from pigs to humans"@en ;
  rdfs:subClassOf obo:OBI_0000105 .

obo:GO_0060206 a rdfs:Class ;
  rdfs:label "estrous cycle phase" ;
  rdfs:comment "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001968 a rdfs:Class ;
  rdfs:label "operational taxonomic unit matrix"@en ;
  rdfs:comment "Operational Taxonomic Unit matrix  is a data item, organized as a table, where organismal taxonomic units, computed by sequence analysis and genetic distance calculation, are counted in a set of biological or environmental samples. The table is  used to appraise biodiversity of a population or community of living organism."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002932 a rdfs:Class ;
  rdfs:label "light trap for outdoor use" ;
  rdfs:comment "A light trap designed to be placed outside a building."@en ;
  rdfs:subClassOf obo:OBI_0002930 .

obo:GO_0050905 a rdfs:Class ;
  rdfs:label "neuromuscular process" ;
  rdfs:comment "Any process pertaining to the functions of the nervous and muscular systems of an organism." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:IAO_0000184 a rdfs:Class ;
  rdfs:label "scatter plot"@en ;
  rdfs:comment "A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis."@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:UBERON_0002812 a rdfs:Class ;
  rdfs:label "left cerebral hemisphere" ;
  rdfs:comment "A cerebral hemisphere that is in the left side of a brain." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0002421 a rdfs:Class ;
  rdfs:label "indicator of whether an inclusion criterion was met" ;
  rdfs:comment "An information content entity that indicates whether or not  an entity has met a specific requirement in order to take part in a given process."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0000051 a rdfs:Class ;
  rdfs:label "liquid chromatography mass spectrometry platform" ;
  rdfs:comment "A liquid chromatography mass spectrometry platform is a platform that is the collection of instrument, software and reagents needed to perform a liquid chromatography mass spectrometry protocol. definition_source: OBI."@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0000932 .

obo:OBI_0001037 a rdfs:Class ;
  rdfs:label "obsolete_specimen fixation function" ;
  rdfs:comment "A specimen fixation function is a function that holds or fastens an entity in a fixed position."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002899 a rdfs:Class ;
  rdfs:label "compound study group role" ;
  rdfs:comment "A study group role that is the result of the allocation of a compound of geographically-proximate households with a shared component in a clinical trial to receive a specific intervention/treatment, or no intervention, according to the trial's protocol."@en ;
  rdfs:subClassOf obo:OBI_0000174 .

obo:OBI_0000399 a rdfs:Class ;
  rdfs:label "solid support function"@en ;
  rdfs:comment "A solid support function is a function of a device on which an entity is kept in a defined position and prevented in its movement"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0400170 a rdfs:Class ;
  rdfs:label "microscope slide" ;
  rdfs:comment "A microscope slide is a device usually made of glass which is used as a solid matrix for (biological) material deposited on its surface and which is compatible for use with a microscope instrument"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003811 a rdfs:Class ;
  rdfs:label "estrous cycle count assay" ;
  rdfs:comment "An estrous cycle assay based on tissue morphology that determines the number of estrous cycles observed in a defined time."@en ;
  rdfs:subClassOf obo:OBI_0003766 .

obo:OBI_0100046 a rdfs:Class ;
  rdfs:label "phosphate buffered saline solution"@en ;
  rdfs:comment "Phosphate buffered saline (abbreviated PBS) is a buffer solution commonly used in biochemistry. It is a salty solution containing sodium chloride, sodium phosphate and in some preparations potassium chloride and potassium phosphate. The buffer helps to maintain a constant pH. The concentration usually matches the human body (isotonic)."@en ;
  rdfs:subClassOf obo:OBI_0302729 .

obo:OBI_0002619 a rdfs:Class ;
  rdfs:label "site-directed mutagenesis" ;
  rdfs:comment "An induced mutation in which a specific base change is programmed into the sequence of a synthetic primer."@en ;
  rdfs:subClassOf obo:OBI_0001154 .

obo:OBI_2100030 a rdfs:Class ;
  rdfs:label "high-density lipoprotein cholesterol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of high-density lipoprotein cholesterol"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:UBERON_0001434 a rdfs:Class ;
  rdfs:label "skeletal system" ;
  rdfs:comment "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003890 a rdfs:Class ;
  rdfs:label "1M4 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 1-methylimidazole-4-carboxylic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0002511 a rdfs:Class ;
  rdfs:label "vitreous humor specimen" ;
  rdfs:comment "A specimen that is derived from vireous humor."@en ;
  rdfs:subClassOf obo:OBI_2000004 .

obo:OBI_0001510 a rdfs:Class ;
  rdfs:label "mass spectrometry assay measuring MHC ligand processing and presentation of MHC ligands eluted from secreted MHC" ;
  rdfs:comment "A mass spectrometry of MHC ligands that identifies eluted ligands from secreted MHC."@en ;
  rdfs:subClassOf obo:OBI_0001478 .

obo:OBI_0003105 a rdfs:Class ;
  rdfs:label "single-cell combinatorial indexing RNA sequencing assay" ;
  rdfs:comment "A single-cell transcription profiling by RNA sequencing assay that involves single cell combinatorial indexing ('sci-') strategy to profile the transcriptomes of single cells or nuclei without single cell isolation."@en ;
  rdfs:subClassOf obo:OBI_0002631 .

obo:OBI_0000860 a rdfs:Class ;
  rdfs:label "northern blot assay" ;
  rdfs:comment "An assay that determines the presence of gene transcripts by hybridizing labeled RNA or DNA probes against messenger RNAs isolated from tissue or cell cultures, resolved on denaturing gel, transfered by a blotting procedure to a solid support. Detection of hybridization signals is carried out by immunofluorescence or radioactivity measurements using photographic films or digital imaging devices such as Phosphor Imager."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000535 a rdfs:Class ;
  rdfs:label "gel filtration column" ;
  rdfs:comment "A Gel filtration column is a chromatography column for size-exclusion chromatography, in which the stationary phase is a gel. The main application of gel filtration chromatography is the fractionation of proteins and other water-soluble polymers."@en ;
  rdfs:subClassOf obo:OBI_0000618 .

obo:OBI_0001346 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-21 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001237 .

obo:OBI_0000540 a rdfs:Class ;
  rdfs:label "isolation of adherent cells" ;
  rdfs:comment "a material separation process in which cells that stick to the container in which they are grown as a cell culture are separated from those in the liquid component of the culture. The output of this process are adherent cells."@en ;
  rdfs:subClassOf obo:OBI_0000512 .

obo:OBI_1110155 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific tumor necrosis factor alpha production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects tumor necrosis factor alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001246 , obo:OBI_0001416 .

obo:OBI_0000845 a rdfs:Class ;
  rdfs:label "obsolete primary structure of RNA molecule" ;
  rdfs:comment "The primary structure of an RNA molecule that is completely defined by the set of its nucleic residue parts and the linear order induced by the peptide bonds that hold them together"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100070 a rdfs:Class ;
  rdfs:label "liver injury venous blood bilirubin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin in venous blood as part of a liver injury order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100018 .

obo:GO_0032615 a rdfs:Class ;
  rdfs:label "interleukin-12 production" ;
  rdfs:comment "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_2100339 a rdfs:Class ;
  rdfs:label "liver function venous blood alanine aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a liver function order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100016 .

obo:IDO_0000528 a rdfs:Class ;
  rdfs:label "pathogen"@en ;
  rdfs:comment "A material entity with a pathogenic disposition."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:MRO_0000971 a rdfs:Class ;
  rdfs:label "H2-IA protein complex" ;
  rdfs:subClassOf obo:MRO_0001461 .

obo:OBI_2100341 a rdfs:Class ;
  rdfs:label "liver function venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a liver function order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_0001403 a rdfs:Class ;
  rdfs:label "ChIP-chip design" ;
  rdfs:comment "A study design which aims to identify protein binding sites in genomic DNA by a combination of chromatin immunoprecipitation and DNA microarray (chip) assays."@en ;
  rdfs:subClassOf obo:OBI_0001425 .

obo:OBI_0400062 a rdfs:Class ;
  rdfs:label "krypton ion laser" ;
  rdfs:comment "A krypton-ion laser is an ion laser that uses krypton as the lasing medium. These lasers can emit at 468, 476, 482, 520, 531, 568, 647 (the most powerful line), and 676 nm all at once. They have much lower gain than argon lasers however."@en ;
  rdfs:subClassOf obo:OBI_0400060 .

obo:OBI_0001998 a rdfs:Class ;
  rdfs:label "immunohistochemistry assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A immunohistochemistry assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001652 , obo:OBI_0001986 .

obo:UBERON_0000483 a rdfs:Class ;
  rdfs:label "epithelium" ;
  rdfs:comment "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:OBI_1110083 a rdfs:Class ;
  rdfs:label "host of immune response role"@en ;
  rdfs:comment "is a role borne by an organism. It is realized by the organism during an immunization or an immune response taking place inside or on the surface of the organism, and in which the responding or stimulated immune system is part of the host."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_2100063 a rdfs:Class ;
  rdfs:label "CBC with automated differential venous blood platelet count assay" ;
  rdfs:comment "A cytometry assay that measures the count of platelets in venous blood as part of a CBC with automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003028 , obo:OBI_0003040 .

obo:OBI_0002190 a rdfs:Class ;
  rdfs:label "courier organization"@en ;
  rdfs:comment "An organization that delivers messages, packages, and mail."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0001644 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific opsonization" ;
  rdfs:comment "A B cell epitope specific activation of additional immune response assay that detects opsonization in vitro ."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001704 .

obo:OBI_0003185 a rdfs:Class ;
  rdfs:label "mean platelet volume assay" ;
  rdfs:comment "A platelet assay that measures the average volume of platelets in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003028 .

obo:NCBITaxon_11050 a rdfs:Class ;
  rdfs:label "Flaviviridae" ;
  rdfs:subClassOf obo:NCBITaxon_2732406 .

obo:OBI_0000435 a rdfs:Class ;
  rdfs:label "genotyping assay" ;
  rdfs:comment "An assay which generates data about a genotype from a specimen of genomic DNA. A variety of techniques and instruments can be used to produce information about sequence variation at particular genomic positions."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:GO_0052689 a rdfs:Class ;
  rdfs:label "carboxylic ester hydrolase activity" ;
  rdfs:comment "Catalysis of the hydrolysis of a carboxylic ester bond." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0000978 a rdfs:Class ;
  rdfs:label "in container assay" ;
  rdfs:comment "An assay in which a measurement is made by observing entities located in a container."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0100056 a rdfs:Class ;
  rdfs:label "obsolete_immortal cell line culture" ;
  rdfs:comment "A cell line that is expected to be capable of indefinite propagation in an vitro culture."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000588 a rdfs:Class ;
  rdfs:label "flame photometric detector" ;
  rdfs:comment "The determination of sulfur or phosphorus containing compounds is the job of the flame photometric detector (FPD). This device uses the chemiluminescent reactions of these compounds in a hydrogen/air flame as a source of analytical information that is relatively specific for substances containing these two kinds of atoms. The emitting species for sulfur compounds is excited S2. The lambda max for emission of excited S2 is approximately 394 nm. The emitter for phosphorus compounds in the flame is excited HPO (lambda max = doublet 510-526 nm). In order to selectively detect one or the other family of compounds as it elutes from the GC column, an interference filter is used between the flame and the photomultiplier tube (PMT) to isolate the appropriate emission band. The drawback here being that the filter must be exchanged between chromatographic runs if the other family of compounds is to be detected."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_2000007 a rdfs:Class ;
  rdfs:label "nasopharynx specimen" ;
  rdfs:comment "A specimen that is derived from some nasopharynx"@en ;
  rdfs:subClassOf obo:OBI_2000006 .

obo:OBI_0000628 a rdfs:Class ;
  rdfs:label "carbon nanotube column" ;
  rdfs:comment "Carbon nanotubes (CNTs) are known to have high thermal and mechanical stability and have the potential to be high-performance separation media that utilize the nanoscale interactions. CNT can be applied in long capillary tubes for the development of gas chromatography columns. A film of CNTs can be deposited by chemical vapor deposition (CVD) to form the stationary phase in the open tubular format. Altering the CVD conditions can vary the thickness and the morphology of the CNT film, which opens the possibility of selectivity tuning. The ability to fabricate long tubes coated with CNTs can be readily employed in other gas- and liquid-phase separations as well."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_1110003 a rdfs:Class ;
  rdfs:label "host exposure to infectious agent"@en ;
  rdfs:comment "a process in which an infectious agent comes into physical contact with a host organism."@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_2100356 a rdfs:Class ;
  rdfs:label "venous blood temperature assay" ;
  rdfs:comment "An assay that measures temperature in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0000146 a rdfs:Class ;
  rdfs:label "supernatant collection system harvesting frame" ;
  rdfs:comment "A device that is designed for collecting 90% of the supernatant in a microplate well and separating the living cell with no stress, eliminating centrifugation and other similar techniques. It can be used in a variety of release assays with different radioactive isotopes, such as Cr51 or I125."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:GO_0004540 a rdfs:Class ;
  rdfs:label "RNA nuclease activity" ;
  rdfs:comment "Catalysis of the cleavage of phosphodiester bonds in chains of RNA." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0400024 a rdfs:Class ;
  rdfs:label "CyFlow SL" ;
  rdfs:comment "a flow_cytometer_analyser manufactured by Partec. Its specs are: ultracompact and fully equipped mobile/portable instrument, dimensions [cm]: L 43 x H 16 x D 37, highest stability/robustness and highest precision, 5 optical parameters: FSC, SSC, FL-1, FL-2, FL-3, 20mW@488nm blue solid state laser , other laser light sources optional (UV, violet, green, red), WindowsTM XP FloMax (software for real time data acquisition, data display, and data evaluation), parallel 16 bit digital pulse processing Compact mobile Flow Cytometer for any kind of cell analysis and absolute volumetric counting. The CyFlow_SL allows to analyze forward and side scatter signals in combination with up to 3 fluorescence channels."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0003396 a rdfs:Class ;
  rdfs:label "Affymetrix Human Transcriptome Array 2.0" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, to go beyond gene-level expression profiling to accurately detect all known transcript isoforms produced by a gene. The array design covers >245,000 coding transcripts, >40,000 non-coding transcripts and >339,000 probe sets covering exon-exon junctions, thus ensuring uniform coverage of the transcriptome."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0002004 a rdfs:Class ;
  rdfs:label "Methylation 450K BeadChip" ;
  rdfs:comment "A methylation BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array interrogates ~ 485,000 methylation sites per sample at single-nucleotide resolution."@en ;
  rdfs:subClassOf obo:OBI_0001870 .

obo:OBI_0000204 a rdfs:Class ;
  rdfs:label "nutrient role"@en ;
  rdfs:comment "a role that inheres in a material entity and is realized in the use of that material entity by an organism when it is used in that organism's metabolism and provides nourishment."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000856 a rdfs:Class ;
  rdfs:label "obsolete intracellular material detection by flow cytometry assay" ;
  rdfs:comment "An assay in which the presence of a material inside a cell is measured by permeabilizing the cell membrane to allow entry of specific antibodies, and counting the stained cells using a flow cytometer."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001924 a rdfs:Class ;
  rdfs:label "micrococcal nuclease digestion followed by high throughput sequencing assay" ;
  rdfs:comment "An assay that identifies nucleosome positioning by genome wide sequencing of regions sensitive to digestion by micrococal nuclease"@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0003022 a rdfs:Class ;
  rdfs:label "neutrophil assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of neutrophils"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0003739 a rdfs:Class ;
  rdfs:label "manual muscle testing 8 score"@en ;
  rdfs:comment "A clinical data item that quantifies the muscle function of a person based on the person's ability to hold a series of eight body positions that target different muscle groups."@en ;
  rdfs:subClassOf obo:OGMS_0000123 .

obo:OBI_0200085 a rdfs:Class ;
  rdfs:label "mass spectrometry analysis"@en ;
  rdfs:comment "A data transformation which has the objective of spectrum analysis."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001831 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-17F production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-17F production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001772 , obo:OBI_1110162 .

obo:OBI_0003141 a rdfs:Class ;
  rdfs:label "categorical binding datum" ;
  rdfs:comment "A binding datum that is expressed as a categorical value."@en ;
  rdfs:subClassOf obo:OBI_0001181 .

obo:CL_0000556 a rdfs:Class ;
  rdfs:label "megakaryocyte" ;
  rdfs:comment "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0003099 a rdfs:Class ;
  rdfs:label "matrix assisted laser desorption ionization imaging mass spectrometry assay" ;
  rdfs:comment "A mass spectrometry assay that involves collection of spatially resolved mass spectra of a sample during microscopy where a pulse laser is used to produce both ionisation and vaporization. The sample is held in a matrix (such as dihydrobenzoic acid) to protect it from direct laser illumination and to separate the sample molecules. The spectra are used to visualise the spatial distribution of biomolecules by their molecular masses."@en ;
  rdfs:subClassOf obo:OBI_0000470 .

obo:OBI_0000493 a rdfs:Class ;
  rdfs:label "rapid resolution column" ;
  rdfs:comment "A rapid resolution column is a chromatography column as marketed by Agilent, which is used with a rapid resolution cartridge to ensure a fast chromatography process with good separation resolution."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:GO_0002524 a rdfs:Class ;
  rdfs:label "hypersensitivity" ;
  rdfs:comment "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0002082 a rdfs:Class ;
  rdfs:label "reporter gene assay" ;
  rdfs:comment "An assay that detects expression of a reporter gene that was inserted under the control of a regulatory sequence of interest."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001666 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring binding on rate [kon] to determine direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures binding on rate (kon) to detect direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001994 .

obo:OBI_0000907 a rdfs:Class ;
  rdfs:label "supplying" ;
  rdfs:comment "A planned process with the objective to provide material entities to be used in an investigation."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:IAO_8000011 a rdfs:Class ;
  rdfs:label "external import ontology module"@en ;
  rdfs:comment "An imported ontology module that is derived from an external ontology. Derivation methods include the OWLAPI SLME approach."@en ;
  rdfs:subClassOf obo:IAO_8000005 .

obo:OBI_0003433 a rdfs:Class ;
  rdfs:label "lactate dehydrogenase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of lactate dehydrogenase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0600027 a rdfs:Class ;
  rdfs:label "artificially induced cell membrane lysis"@en ;
  rdfs:comment "a material transformation to break the membranes of cells, releasing the cells contents; input=>cells; output=>cell_lysate"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000374 a rdfs:Class ;
  rdfs:label "excitation function"@en ;
  rdfs:comment "A excitation function is a function  to inject energy by bombarding a material with energetic particles (e.g., photons) thereby imbuing internal material components such as electrons with additional energy.  These internal, 'excited' particles may lead to the rupturing of covalent chemical bonds or may quickly relax back to there unexcited state with an exponential time course thereby locally emitting energy in the form of photons."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0002370 a rdfs:Class ;
  rdfs:label "unknown clinical history of cancer" ;
  rdfs:comment "A clinical history in which it is not known whether there was a diagnosis of cancer."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0001918 a rdfs:Class ;
  rdfs:label "RNA-binding protein immunoprecipitation array profiling assay" ;
  rdfs:comment "An assay that combines immunoprecipitation of an RNA-binding protein and array technology to identify mRNAs associated with selected RNA binding proteins (RBPs)."@en ;
  rdfs:subClassOf obo:OBI_0001985 .

obo:OBI_0002175 a rdfs:Class ;
  rdfs:label "ATP bioluminescence assay" ;
  rdfs:comment "An analyte assay that detects ATP concentration through light intensity when luciferase catalyzes the oxidation of luciferin in the presence of ATP, magnesium ions, and molecular oxygen."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003833 a rdfs:Class ;
  rdfs:label "neuron action potential rate assay" ;
  rdfs:comment "An electrophysiology assay that measures action potential events in neurons during a time period."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0002176 .

obo:GO_0002367 a rdfs:Class ;
  rdfs:label "cytokine production involved in immune response" ;
  rdfs:comment "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0400088 a rdfs:Class ;
  rdfs:label "quartz cuvette flow chamber" ;
  rdfs:comment "A flow cell in which the laser irradiates the cell as it passes through a quartz cuvette. A quartz cuvette flow chamber can be used to allow the laser to irradiate cells."@en ;
  rdfs:subClassOf obo:OBI_0400043 .

obo:OBI_0002657 a rdfs:Class ;
  rdfs:label "surgical biopsy" ;
  rdfs:comment "A biopsy involving a surgical incision into an organism to access the biopsy material."@en ;
  rdfs:subClassOf obo:OBI_0002650 .

obo:OBI_0001607 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific tumor necrosis factor (ligand) superfamily member 11 production by T cells" ;
  rdfs:comment "An assay of epitope specific tumor necrosis factor (ligand) superfamily member 11 production by T cells that detects tumor necrosis factor production."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001400 .

obo:OBI_0001286 a rdfs:Class ;
  rdfs:label "RNAi profiling by array design" ;
  rdfs:comment "A study design in which experiment double stranded RNA is synthesized with a sequence complementary to a gene(s) of interest and introduced into a cell or organism, where it is recognized as exogenous genetic material and activates the RNAi pathway resulting in knockdown of the transcripts and providing a means to study downstream changes in gene expression."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001674 a rdfs:Class ;
  rdfs:label "cap analysis of gene expression assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay which measures RNA transcript abundances in biological samples by extracting 5' ends of capped transcripts, RTPCR and sequence those. Copy numbers of CAGE tags provide a way of quantification and provide a measure of expression of the transcriptome"@en ;
  rdfs:subClassOf obo:OBI_0001177 , obo:OBI_0001271 , obo:OBI_0002692 .

obo:OBI_0002705 a rdfs:Class ;
  rdfs:label "direct insecticide resistance bioassay" ;
  rdfs:comment "An insecticide resistance bioassay without the use of any synergist."@en ;
  rdfs:subClassOf obo:OBI_0002698 .

obo:OBI_0003771 a rdfs:Class ;
  rdfs:label "neurite degree of arborization assay" ;
  rdfs:comment "A cytometry assay that measures the degree of arborization, or branching, in neuronal processes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000606 a rdfs:Class ;
  rdfs:label "open tubular column" ;
  rdfs:comment "An open tubular column is a chromatography column in which the particles of the solid stationary phase or the support coated with a liquid stationary phase are concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CLO_0009829 a rdfs:Class ;
  rdfs:label "mortal cell line"@en ;
  rdfs:comment "A cell line is able to support only a limited number of passages in vitro." ;
  rdfs:subClassOf obo:CLO_0000031 .

obo:OBI_0000793 a rdfs:Class ;
  rdfs:label "double blind study execution" ;
  rdfs:comment "A double blind study execution is defined as any study execution in which neither the subjects nor the investigators are informed of which study arm the subjects are part of during the portion of the trial when the subjects are being treated"@en ;
  rdfs:subClassOf obo:OBI_0000822 , obo:OBI_0000826 .

obo:OBI_0003326 a rdfs:Class ;
  rdfs:label "high throughput multiplexed assay measuring MHC ligand processing and presentation" ;
  rdfs:comment "A MHC ligand assay that determines what ligands are processed and loaded onto MHC molecules by eluting ligands and identifying them using a high throughput multiplexed assay."@en ;
  rdfs:subClassOf obo:OBI_1110125 .

obo:OBI_0000424 a rdfs:Class ;
  rdfs:label "transcription profiling assay" ;
  rdfs:comment "An assay that determines gene expression and transcription activity using ribonucleic acids collected from a material entity."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002052 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection after tumor burden challenge" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from tumor challenge using tumor burden."@en ;
  rdfs:subClassOf obo:OBI_0003458 , obo:OBI_0003466 .

obo:OBI_0002978 a rdfs:Class ;
  rdfs:label "input gene sequence stop site" ;
  rdfs:comment "The position of the last nucelotide in a gene sequence being analyzed (input gene sequence)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:PR_000005897 a rdfs:Class ;
  rdfs:label "C-reactive protein" ;
  rdfs:comment "A protein that is a translation product of the human CRP gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:IAO_0000007 a rdfs:Class ;
  rdfs:label "action specification"@en ;
  rdfs:comment "A directive information entity that describes an action the bearer will take."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:GO_0032608 a rdfs:Class ;
  rdfs:label "interferon-beta production" ;
  rdfs:comment "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0302901 a rdfs:Class ;
  rdfs:label "obsolete_activation" ;
  rdfs:comment "a process by which a material entity status is modified and conferred a capability of reacting (this sounds like a circular definition , hugh!)"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001801 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-8 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-8 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001218 .

obo:OBI_2000015 a rdfs:Class ;
  rdfs:label "capillary blood specimen" ;
  rdfs:comment "A specimen that is derived from some capillary blood"@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0001367 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-10 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001209 .

obo:OBI_0000744 a rdfs:Class ;
  rdfs:label "material sampling process" ;
  rdfs:comment "A specimen gathering process with the objective to obtain a specimen that is representative of the input material entity"@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:OBI_0002071 a rdfs:Class ;
  rdfs:label "in vitro assay measuring epitope specific proliferation of T cells" ;
  rdfs:comment "A T cell epitope specific proliferation assay that is performed on cells in vitro."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110131 .

obo:OBI_0003156 a rdfs:Class ;
  rdfs:label "hemoglobin concentration assay" ;
  rdfs:comment "A hemoglobin assay that measures the amount of hemoglobin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100014 .

obo:CHEBI_32875 a rdfs:Class ;
  rdfs:label "methyl group" ;
  rdfs:comment "An alkyl group that is the univalent group derived from methane by removal of a hydrogen atom." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003917 a rdfs:Class ;
  rdfs:label "image transformation" ;
  rdfs:comment "A data transformation that applies a rule or formula to each pixel or set of pixels in an image to change that image in some way. Produces a transformed image data set or derived data item."@en ;
  rdfs:subClassOf obo:OBI_0003355 .

obo:GO_0071745 a rdfs:Class ;
  rdfs:label "IgA immunoglobulin complex" ;
  rdfs:comment "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ;
  rdfs:subClassOf obo:GO_0019814 .

obo:PATO_0000051 a rdfs:Class ;
  rdfs:label "morphology" ;
  rdfs:comment "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBI_0001339 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-4 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001450 .

obo:OBI_0200121 a rdfs:Class ;
  rdfs:label "standard deviation calculation"@en ;
  rdfs:comment "A standard deviation calculation is a descriptive statistics calculation defined as the square root of the variance.  Also thought of as the average distance of each value to the mean."@en ;
  rdfs:subClassOf obo:OBI_0200086 , obo:OBI_0200184 .

obo:OBI_0200002 a rdfs:Class ;
  rdfs:label "logistic-log curve fitting"@en ;
  rdfs:comment "A logistic-log curve fitting is a curve fitting where a curve of the form y=d+((a-d)/(1+(x/c)^b)) is obtained, where a, b, c, and d are determined so to optimize its fit to the input data points (x_1, y_1), (x_2, y_2), ..., (x_n, y_n)."@en ;
  rdfs:subClassOf obo:OBI_0200072 .

obo:OBI_0002915 a rdfs:Class ;
  rdfs:label "human-biting indoor arthropod specimen collection by aspiration" ;
  rdfs:comment "An arthropod specimen collection by aspiration that occurs while the arthropod is biting a human inside a building."@en ;
  rdfs:subClassOf obo:OBI_0002914 .

obo:OBI_0001067 a rdfs:Class ;
  rdfs:label "perfusion station" ;
  rdfs:comment "A device or system in which perfusion units are integrated."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_1110054 a rdfs:Class ;
  rdfs:label "autoimmune disease"@en ;
  rdfs:comment "Is a disease characterized by an immune response of an organism against parts of itself"@en ;
  rdfs:subClassOf obo:OGMS_0000031 .

obo:OBI_0001711 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific disease exacerbation" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that uses a disease exacerbation in vivo intervention experiment."@en ;
  rdfs:subClassOf obo:OBI_0001188 , obo:OBI_0001698 .

obo:GO_0044809 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 17 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0001248 a rdfs:Class ;
  rdfs:label "ChIP-chip assay" ;
  rdfs:comment "An assay in which chromatin is immunoprecipitated and subsequently analyzed using a DNA microarray to identify which parts of DNA are part of the isolated chromatin"@en ;
  rdfs:subClassOf obo:OBI_0001954 .

obo:OBI_0001109 a rdfs:Class ;
  rdfs:label "bead array reader" ;
  rdfs:comment "A device that is used to acquire and image bead array data."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:IAO_0000088 a rdfs:Class ;
  rdfs:label "report"@en ;
  rdfs:comment "A document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record)."@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0002404 a rdfs:Class ;
  rdfs:label "no hormonal birth control use history" ;
  rdfs:comment "A hormonal birth control use history that indicates an individual has not ever been a hormonal birth control user."@en ;
  rdfs:subClassOf obo:OBI_0002401 .

obo:OBI_0002807 a rdfs:Class ;
  rdfs:label "disposable footwear cover" ;
  rdfs:comment "A footwear cover which is designed for a single period of continuous use and then disposed of."@en ;
  rdfs:subClassOf obo:OBI_0002806 .

obo:CHEBI_23965 a rdfs:Class ;
  rdfs:label "estradiol" ;
  rdfs:comment "A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002116 a rdfs:Class ;
  rdfs:label "high performance liquid chromatography assay" ;
  rdfs:comment "An analytical chromatography assay that utilizes a high performance liquid chromatography instrument for separation of compounts in a solution."@en ;
  rdfs:subClassOf obo:OBI_0001630 .

obo:GO_0003939 a rdfs:Class ;
  rdfs:label "L-iditol 2-dehydrogenase (NAD+) activity" ;
  rdfs:comment "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. Acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0002003 a rdfs:Class ;
  rdfs:label "Illumina MiSeq" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation. Built upon sequencing by synthesis technology, the machine provides an end-to-end solution (cluster generation, amplification, sequencing, and data analysis) in a single machine."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_2100097 a rdfs:Class ;
  rdfs:label "total venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:NCBITaxon_4896 a rdfs:Class ;
  rdfs:label "Schizosaccharomyces pombe" ;
  rdfs:subClassOf obo:NCBITaxon_4890 .

obo:OBI_0003906 a rdfs:Class ;
  rdfs:label "neural network spike duration assay" ;
  rdfs:comment "A multi-electrode assay that measures the mean duration of events when multiple electrodes detect an action potential"@en ;
  rdfs:subClassOf obo:OBI_0003901 .

obo:GO_0001764 a rdfs:Class ;
  rdfs:label "neuron migration" ;
  rdfs:comment "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." ;
  rdfs:subClassOf obo:GO_0016477 .

obo:NCBITaxon_39107 a rdfs:Class ;
  rdfs:label "Murinae" ;
  rdfs:subClassOf obo:NCBITaxon_9989 .

obo:OBI_0002989 a rdfs:Class ;
  rdfs:label "material supplier" ;
  rdfs:comment "A person or organization that provides material supplies to other people or organizations."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0100015 a rdfs:Class ;
  rdfs:label "obsolete_anatomical entity" ;
  rdfs:comment "An anatomical entity is a material entity that is part of a multicellular organism, and which is large enough so that it forms an identifiable structure in the organism. Specifically, it excludes granular parts of the organism, such as atoms, molecules, cells, which can be removed from the organism without affecting it. It is defined as the union of 'multi-tissue structure', 'body substance' and 'portion of tissue'"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000708 a rdfs:Class ;
  rdfs:label "laboratory animal care" ;
  rdfs:comment "a process that realizes an animal care protocol that specifies how animals are kept and maintained"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002995 a rdfs:Class ;
  rdfs:label "blood meal source organism" ;
  rdfs:comment "An organism that is the source of a blood meal."@en ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0003116 a rdfs:Class ;
  rdfs:label "antibody detection by cytometric bead array assay" ;
  rdfs:comment "A cytometric bead array assay that detects antigen-specific antibodies. In the assay a series of beads are coated with antigens which capture antibodies specific to the antigens. Fluorescent labeled secondary antibodies are used to detect the antibodies of interest."@en ;
  rdfs:subClassOf obo:OBI_0000920 .

obo:OBI_0003315 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific amphiregulin production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects amphiregulin production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001515 a rdfs:Class ;
  rdfs:label "material maintenance service" ;
  rdfs:comment "A material processing service in which a service provider makes physical modifications to a specified input material, such that at least one of the specified outputs of this process is a modified version of a specified input material."@en ;
  rdfs:subClassOf obo:OBI_0001528 .

obo:OBI_0400031 a rdfs:Class ;
  rdfs:label "dichroic mirror" ;
  rdfs:comment "A dichroic mirror is an optical filter which is used to selectively reflect light of a small range of colors while passing other colors. A dichroic filter passes the specified range of light whereas a dichroic mirror reflects the specified range of light."@en ;
  rdfs:subClassOf obo:OBI_0400079 .

obo:OBI_0000463 a rdfs:Class ;
  rdfs:label "column chromatography detector" ;
  rdfs:comment "There is a wide range of detectors available for both GC and LC each having their own particular areas of application. In general the more catholic the response, the less sensitive the detector and the most sensitive detectors are those that have a specific response. The performance of all detectors should be properly specified so that the user can determine which is most suitable for a specific application. Such specifications are also essential to compare the performance of different detectors supplied by alternative instrument manufactures. Detector specifications should be presented in a standard form and in standard units, so that detectors can be compared that function on widely different principles."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0003438 a rdfs:Class ;
  rdfs:label "galactosidase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of galactosidase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0001479 a rdfs:Class ;
  rdfs:label "specimen from organism" ;
  rdfs:comment "A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm)."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0002623 a rdfs:Class ;
  rdfs:label "whole metagenome sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that intends to provide information on the DNA sequences of multiple genomes (a metagenome) from different organisms present in the same input sample."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:CHEBI_31991 a rdfs:Class ;
  rdfs:label "phenol red" ;
  rdfs:comment "3<em>H</em>-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001700 a rdfs:Class ;
  rdfs:label "immunoprecipitation assay" ;
  rdfs:comment "An analyte assay in which an input material is mixed with antibodies and bound antigen:antibody complexes are separated out using immunoprecipitation. Either the antibody has known specificy, and the antigen mixture is tested for the presence of a specific antigen, or the antigen solution is well defined and the antibody solution is tested for the presence of antigen specific antibodies."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0400102 a rdfs:Class ;
  rdfs:label "waste tank" ;
  rdfs:comment "Part of the fluidics systems. In analyzers the sheath and sample fluid, once analyzed is dumped into a waste tank. The waste tank is where the fluids passing through the cytometer end up after the analysis is finished."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0003767 a rdfs:Class ;
  rdfs:label "organism development assay in late embryo" ;
  rdfs:comment "An organism development assay performed with a late embryo stage subject."@en ;
  rdfs:subClassOf obo:OBI_0003713 .

obo:OBI_0001328 a rdfs:Class ;
  rdfs:label "organism development design" ;
  rdfs:comment "A study design that assays events associated with development. Development applies to organism(s) acquiring a mature state."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002954 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based protein phosphorylation state assay" ;
  rdfs:comment "A type of protein state assay that employs high-throughput microscopy to measure levels of proteins in different phosphorylation states."@en ;
  rdfs:subClassOf obo:OBI_0002953 .

obo:IAO_0000573 a rdfs:Class ;
  rdfs:label "line graph"@en ;
  rdfs:comment """A line graph is a type of graph created by connecting a series of data
points together with a line."""@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:OBI_0001485 a rdfs:Class ;
  rdfs:label "purified MHC molecule preparation" ;
  rdfs:comment "A mixture containing MHC molecules that was purified to remove non-MHC molecular entities."@en ;
  rdfs:subClassOf obo:OBI_0001633 .

obo:OBI_0400051 a rdfs:Class ;
  rdfs:label "Guava Personal Cell Analysis-96" ;
  rdfs:comment "The Guava_Personal_Cell_Analysis-96 Systems is a flow_cytometer_analyser that includes a single 532 nm laser, and filters and PMTs to collect up to 2 fluorescent parameters. It includes a photodiode forward scatter collector. Guava cytometers use aspiration instead of fluid systems to transport cells within the machine. The PCA96 uses either tubes or 96 well plates to introduce specimen. The Guava PCA -96 cytometer is a small portable cytometer particularly useful for field measurement."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0000513 a rdfs:Class ;
  rdfs:label "DISCOVERY console" ;
  rdfs:comment "The Discovery console is a Windows XP Professional-based, integrated console designed especially for Solid-State NMR. The console includes everything needed to interface to any magnet and solids probe - from computer to cables to duplexing network."@en ;
  rdfs:subClassOf obo:OBI_0000599 .

obo:CHEBI_28358 a rdfs:Class ;
  rdfs:label "rac-lactic acid" ;
  rdfs:comment "A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-lactic acid." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0001909 a rdfs:Class ;
  rdfs:label "conclusion based on data" ;
  rdfs:comment "An information content entity that is inferred from data."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003466 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from tumor challenge" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from tumor challenge."@en ;
  rdfs:subClassOf obo:OBI_0001183 , obo:OBI_0001710 .

obo:OBI_0002920 a rdfs:Class ;
  rdfs:label "arthropod trap" ;
  rdfs:comment "A device designed to catch arthropods."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001722 a rdfs:Class ;
  rdfs:label "B cell epitope specific hypersensitivity" ;
  rdfs:comment "hypersensitivity resulting from antibody binding to epitope"@en ;
  rdfs:subClassOf obo:GO_0002524 .

obo:OBI_0001737 a rdfs:Class ;
  rdfs:label "obsolete B cell epitope specific X-ray crystallography assay" ;
  rdfs:comment "A X-ray crystallography assay measuring epitope specfic antibody binding event in angstroms"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0302899 a rdfs:Class ;
  rdfs:label "decapitation"@en ;
  rdfs:comment "decapitation is a process by which the head of a living organism is physically removed from the body, usually resulting in rapid death (in the case of Rhodnius prolixus, it might take a bit longer..)"@en ;
  rdfs:subClassOf obo:OBI_0000919 .

obo:OBI_0001827 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-C motif) ligand 1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001276 .

obo:OBI_0003238 a rdfs:Class ;
  rdfs:label "umbilical cord blood assay" ;
  rdfs:comment "An assay that has an umbilical cord blood specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003040 .

obo:OBI_0000423 a rdfs:Class ;
  rdfs:label "extract"@en ;
  rdfs:comment "an extract is a material entity which results from an extraction process"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0001532 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-9 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001253 , obo:OBI_0003115 .

obo:OBI_0002926 a rdfs:Class ;
  rdfs:label "Centers for Disease Control and Prevention light trap" ;
  rdfs:comment "A light trap that is designed similarly to the New Jersey trap—in that it uses motorized suction and light attractant—and is powered by a six-volt battery."@en ;
  rdfs:subClassOf obo:OBI_0002930 .

obo:CHEBI_4431 a rdfs:Class ;
  rdfs:label "deoxyribonucleotide" ;
  rdfs:comment "A nucleotide in which the ribose moiety has one or more of its hydroxy groups substituted by hydrogen." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000169 a rdfs:Class ;
  rdfs:label "placebo role"@en ;
  rdfs:comment "a negative reference substance is a reference role in which the substance playing the reference substance role is physically similar in appearance to the test substance"@en ;
  rdfs:subClassOf obo:OBI_0000214 .

obo:GO_0071742 a rdfs:Class ;
  rdfs:label "IgE immunoglobulin complex" ;
  rdfs:comment "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ;
  rdfs:subClassOf obo:GO_0019814 .

obo:OBI_0001442 a rdfs:Class ;
  rdfs:label "q-value" ;
  rdfs:comment """A quantitative confidence value that measures the minimum false discovery rate that is incurred when calling that test significant. 
To compute q-values, it is necessary to know the p-value produced by a test and possibly set a false discovery rate level."""@en ;
  rdfs:subClassOf obo:OBI_0000071 .

obo:OBI_0002085 a rdfs:Class ;
  rdfs:label "transcript expression location detection by hybridization chain reaction assay" ;
  rdfs:comment "An in situ hybridization assay in which the location (e.g. anatomical/tissue) of a transcript is detected by a multiplexed fluorescent in situ hybridization, based on orthogonal amplification with hybridization chain reactions (HCR). RNA probes complementary to mRNA targets trigger chain reactions in which fluorophore-labeled RNA hairpins self-assemble into tethered fluorescent amplification polymers."@en ;
  rdfs:subClassOf obo:OBI_0001686 .

obo:OBI_0000405 a rdfs:Class ;
  rdfs:label "primer role"@en ;
  rdfs:comment "a complementary nucleotide probe role which inheres in nucleic acid molecular entity and is realized by the use of the entity bearing the role to initiate chain elongation."@en ;
  rdfs:subClassOf obo:OBI_0000857 .

obo:OBI_0000736 a rdfs:Class ;
  rdfs:label "single fragment library" ;
  rdfs:comment "is a collection of short tags from DNA fragments, are extracted and covalently linked as single tag constructs"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0002594 a rdfs:Class ;
  rdfs:label "direct interaction identification design" ;
  rdfs:comment "A molecular interaction identification design that investigates the influence of molecules, which are in direct contact, on one another."@en ;
  rdfs:subClassOf obo:OBI_0002590 .

obo:OBI_1110057 a rdfs:Class ;
  rdfs:label "MHC:epitope complex binding to TCR"@en ;
  rdfs:comment "a process of an MHC molecule binding to an entity playing the role of epitope to create an MHC:epitope complex which is then bound by a TCR molecule."@en ;
  rdfs:subClassOf obo:OBI_0001588 , obo:OBI_1110014 .

obo:OBI_0003196 a rdfs:Class ;
  rdfs:label "estradiol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of estradiol"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:BFO_0000015 a rdfs:Class ;
  rdfs:label "process"@en .

obo:OBI_0400099 a rdfs:Class ;
  rdfs:label "flow cytometer sorter" ;
  rdfs:comment "A flow_cytometer_sorter is a flow_cytometer that analyzes and separates or sorts particles passing through (based on properties measured during analysis) to collect cells of interest."@en ;
  rdfs:subClassOf obo:OBI_0000932 , obo:OBI_0400044 .

obo:OBI_2100197 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood lactic acid assay" ;
  rdfs:comment "An assay that measures lactic acid in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100042 .

obo:GO_0042098 a rdfs:Class ;
  rdfs:label "T cell proliferation" ;
  rdfs:comment "The expansion of a T cell population by cell division. Follows T cell activation." ;
  rdfs:subClassOf obo:GO_0008283 .

obo:OBI_0002984 a rdfs:Class ;
  rdfs:label "capture Hi-C assay" ;
  rdfs:comment "A Hi-C assay in which a selection step is performed on ligated fragments in order to enrich for ligation products containing specific regions of interest."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:OBI_0000454 a rdfs:Class ;
  rdfs:label "extracellular electrophysiology recording assay" ;
  rdfs:comment "An electrophysiology assay where the recording location of the electrode is extracellular."@en ;
  rdfs:subClassOf obo:OBI_0002176 .

obo:UBERON_0001264 a rdfs:Class ;
  rdfs:label "pancreas" ;
  rdfs:comment "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0001362 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-C motif) ligand 4 production by T cells" ;
  rdfs:comment "A process of chemokine (C-C motif) ligand 4 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071606 , obo:OBI_0001193 .

obo:OBI_0001979 a rdfs:Class ;
  rdfs:label "fluorescence quenching binding assay" ;
  rdfs:comment "A binding assay in which the proximity of two entities is monitored by measuring a fluorescent signal of one of the entities that gets reduced if the two entities are cliose to each other."@en ;
  rdfs:subClassOf obo:OBI_0001499 .

obo:OBI_0001759 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-X-C motif) ligand 12 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-X-C motif) ligand 12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001776 .

obo:OBI_0001842 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-1 beta production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-1 beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001449 , obo:OBI_0600031 .

obo:OBI_0400147 a rdfs:Class ;
  rdfs:label "microarray" ;
  rdfs:comment "A processed material that is made to be used in an analyte assay. It consists of a physical immobilisation matrix in which substances that bind the analyte are placed in regular spatial position."@en ;
  rdfs:subClassOf obo:OBI_0001865 .

obo:OBI_0001655 a rdfs:Class ;
  rdfs:label "phage display assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A phage display binding assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001476 , obo:OBI_0001703 .

obo:OBI_0003726 a rdfs:Class ;
  rdfs:label "maximum data transformation" ;
  rdfs:comment "A data transformation that has as its output the greatest value in the input data set."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0002663 a rdfs:Class ;
  rdfs:label "skinpunch biopsy" ;
  rdfs:comment "A biopsy that involves the collection of a cylinder of skin (including epidermis, dermis and superficial fat) using a punch tool."@en ;
  rdfs:subClassOf obo:OBI_0002650 .

obo:OBI_0302859 a rdfs:Class ;
  rdfs:label "genetically modified organism"@en ;
  rdfs:comment "an organism that is the output of a genetic transformation process"@en ;
  rdfs:subClassOf obo:COB_0000022 , obo:OBI_0001151 .

obo:OBI_0001782 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects macrophage inflammatory protein-1 gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001456 .

obo:OBI_0000918 a rdfs:Class ;
  rdfs:label "Dulbecco's modified Eagle medium" ;
  rdfs:comment "A culture medium containing iron, phenol red, amino acids, salts, glucose and vitamins."@en ;
  rdfs:subClassOf obo:OBI_0000079 .

obo:OBI_2100204 a rdfs:Class ;
  rdfs:label "venous blood digoxin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of digoxin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_2100182 a rdfs:Class ;
  rdfs:label "ionized arterial blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in arterial blood as part of a ionized order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:MRO_0001498 a rdfs:Class ;
  rdfs:label "mouse MHC protein complex with H2-p haplotype" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:GO_0043565 a rdfs:Class ;
  rdfs:label "sequence-specific DNA binding" ;
  rdfs:comment "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." ;
  rdfs:subClassOf obo:OBI_0001588 .

obo:OBI_2100323 a rdfs:Class ;
  rdfs:label "venous blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:PATO_0000014 a rdfs:Class ;
  rdfs:label "color" ;
  rdfs:comment "A composite chromatic quality composed of hue, saturation and intensity parts." ;
  rdfs:subClassOf obo:PATO_0000051 , obo:PATO_0001300 .

obo:OBI_0003709 a rdfs:Class ;
  rdfs:label "assessment of learning and/or memory response in an organism" ;
  rdfs:comment "A nervous system functionality assessment of learning or memory in an organism"@en ;
  rdfs:subClassOf obo:OBI_0003533 .

obo:UBERON_0000473 a rdfs:Class ;
  rdfs:label "testis" ;
  rdfs:comment "A gonad of a male animal. A gonad produces and releases sperm." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0002668 a rdfs:Class ;
  rdfs:label "in vivo assay measuring epitope specific proliferation of T cells resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "A T cell epitope specific proliferation assay that is performed in vivo after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002070 , obo:OBI_0002676 .

obo:NCBITaxon_33154 a rdfs:Class ;
  rdfs:label "Opisthokonta" ;
  rdfs:subClassOf obo:NCBITaxon_2759 .

obo:OBI_0302714 a rdfs:Class ;
  rdfs:label "obsolete_collection (of entities of organismal origin)" ;
  rdfs:comment "a collection is a bfo:aggregate object, that is a set of material object of the same kind"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003252 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid assay datum" ;
  rdfs:comment "A data entity that is the specified output of a cerebrospinal fluid assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000617 a rdfs:Class ;
  rdfs:label "fluorine-induced chemiluminescence detector" ;
  rdfs:comment "A gas chromatographic detection system based on the low pressure, gas phase chemiluminescence of the reaction mixture of molecular fluorine with organo-sulfur, -selenium, and -tellurium compounds separated from (gas phase) headspace samples. This detector was originally developed in the research group of John Birks at the University of Colorado, USA and was manufactured and sold by Sievers Instruments (Boulder Colorado, USA). This system can be divided up into three parts: the chromatograph, transfer line, and reaction cell; PMT and photon counting electronics; and the molecular fluorine generator."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_2100118 a rdfs:Class ;
  rdfs:label "total venous blood protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in venous blood as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0600053 a rdfs:Class ;
  rdfs:label "electrophoresis"@en ;
  rdfs:comment "a protocol application that uses an electrical potential to move material through a defined matrix in order to separate it by its resistance to movement and its charge"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0000609 a rdfs:Class ;
  rdfs:label "glass column" ;
  rdfs:comment "A glass column is a chromatography column made out of glass that is usually used for larger scale and preparative liquid chromatography separations."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0002099 a rdfs:Class ;
  rdfs:label "assay measuring the off rate [koff] of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A T cell epitope binding constant determination assay that measures the off rate."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002059 .

obo:OBI_0002588 a rdfs:Class ;
  rdfs:label "supervised machine learning" ;
  rdfs:comment "A machine learning process using a function that maps an input to an output based on example input-output pairs. It infers a function from labeled training data consisting of a set of training examples."@en ;
  rdfs:subClassOf obo:OBI_0002587 .

obo:OBI_0002100 a rdfs:Class ;
  rdfs:label "assay measuring the association constant [KA] of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A T cell epitope binding constant determination assay that measures the association constant KA."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002059 .

obo:UBERON_0001013 a rdfs:Class ;
  rdfs:label "adipose tissue" ;
  rdfs:comment "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." ;
  rdfs:subClassOf obo:UBERON_0002384 .

obo:OBI_0003614 a rdfs:Class ;
  rdfs:label "disease prevalence reduction objective"@en ;
  rdfs:comment "An objective specification that is fulfilled by reducing the prevalence of a disease in a population of organisms."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0000296 a rdfs:Class ;
  rdfs:label "obsolete_enrollment" ;
  rdfs:comment "enrollment is a process of identifying a set of objects for further use in an investigation based on a set of criteria or rules"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003478 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using survival."@en ;
  rdfs:subClassOf obo:OBI_0003469 , obo:OBI_0003477 .

obo:OBI_0000388 a rdfs:Class ;
  rdfs:label "connection function"@en ;
  rdfs:comment "A connection function is a function to couple two or more flow channels so that material or signals can be transported from one set of channels to another."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0001351 a rdfs:Class ;
  rdfs:label "epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "A process of tumor necrosis factor superfamily cytokine production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071706 , obo:OBI_0001193 .

obo:OBI_2100261 a rdfs:Class ;
  rdfs:label "total venous blood T3 assay" ;
  rdfs:comment "An analyte assay that measures the abundance of T3 in venous blood as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100046 .

obo:OBI_0001436 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific granzyme B release by T cells" ;
  rdfs:comment "A T cell epitope specific cytotoxic T cell degranulation assay that detects granzyme B release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001269 .

obo:OBI_0200188 a rdfs:Class ;
  rdfs:label "cross validation objective"@en ;
  rdfs:comment "A cross validation objective is a data transformation objective in which the aim is to partition a sample of data into subsets such that the analysis is initially performed on a single subset, while the other subset(s) are retained for subsequent use in confirming and validating the initial analysis."@en ;
  rdfs:subClassOf obo:OBI_0200172 .

obo:OBI_0003697 a rdfs:Class ;
  rdfs:label "clinical investigation"@en ;
  rdfs:comment "An investigation on human subjects with the objective to produce information on human health."@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_0003826 a rdfs:Class ;
  rdfs:label "specific gravity assay" ;
  rdfs:comment "An assay that measures the specific gravity of a sample."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001708 a rdfs:Class ;
  rdfs:label "assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope binding constant determination assay that measures the dissociation constant KD."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001709 .

obo:OBI_2100094 a rdfs:Class ;
  rdfs:label "venous blood creatine kinase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatine kinase in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100025 .

obo:OBI_0000691 a rdfs:Class ;
  rdfs:label "ABI 377 automated sequencer" ;
  rdfs:comment "is a DNA sequencer which is manufactured by Applied Biosystems corporation (formerly Perkin-Elmer). It allows automated chain termination DNA sequencing. It has part polyacrylamide gel electrophoresis system and a laser -based detection system to detect fluorescence intensity emitted by the dyes attached to the dideoxyterminator nucleotides or to the primers."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_2100171 a rdfs:Class ;
  rdfs:label "venous blood tacrolimus assay" ;
  rdfs:comment "An analyte assay that measures the abundance of tacrolimus in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_0000871 a rdfs:Class ;
  rdfs:label "viral hemagglutination assay" ;
  rdfs:comment "An assay that quantifies viruses by their hemagglutination activity."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000610 a rdfs:Class ;
  rdfs:label "auto injector" ;
  rdfs:comment "A gas chromatography device that can auto-inject a small number of samples an inlet."@en ;
  rdfs:subClassOf obo:OBI_0000504 .

obo:OBI_0302912 a rdfs:Class ;
  rdfs:label "electroporation"@en ;
  rdfs:comment "a process in which a significant increase in the electrical conductivity and permeability of the cell plasma membrane caused by an externally applied electrical field. It is usually used in molecular biology as a way of introducing some substance into a cell, such as loading it with a molecular probe, a drug that can change the cell's function, or a piece of coding DNA"@en ;
  rdfs:subClassOf obo:OBI_0600033 .

obo:OBI_0002904 a rdfs:Class ;
  rdfs:label "adult arthropod specimen collection process" ;
  rdfs:comment "A live arthropod specimen collection process in which the arthropods are in the adult stage."@en ;
  rdfs:subClassOf obo:OBI_0002919 .

obo:GO_0071924 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 22 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0003896 a rdfs:Class ;
  rdfs:label "5NIA RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 5-nitroisatoic anhydride as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0003528 a rdfs:Class ;
  rdfs:label "bulbar assessment" ;
  rdfs:comment "A functional assessment of an individual's lower cranial nerve function via proxy of facial muscle performance."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:PATO_0001161 a rdfs:Class ;
  rdfs:label "diluted" ;
  rdfs:comment "A concentration which relatively low." ;
  rdfs:subClassOf obo:PATO_0000033 .

obo:OBI_0000251 a rdfs:Class ;
  rdfs:label "cluster"@en ;
  rdfs:comment "A data set which is a subset of data that are a similar to each other in some way."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0001460 a rdfs:Class ;
  rdfs:label "genetic modification design" ;
  rdfs:comment "A study design in which an organism(s) is studied that has had genetic material removed, rearranged, mutagenized or added, such as in a knock out."@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:OBI_0001136 a rdfs:Class ;
  rdfs:label "surface plasmon resonance instrument" ;
  rdfs:comment "A tool for measuring adsorption of material onto planar metal (typically gold and silver) surfaces or onto the surface of metal nanoparticles."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_2100268 a rdfs:Class ;
  rdfs:label "tube 1 count cerebrospinal fluid cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of cells in cerebrospinal fluid as part of a tube 1 count order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003232 .

obo:OBI_0003263 a rdfs:Class ;
  rdfs:label "eukaryota in blood datum" ;
  rdfs:comment "A blood microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003244 .

obo:PR_000009758 a rdfs:Class ;
  rdfs:label "leptin" ;
  rdfs:comment "A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003416 a rdfs:Class ;
  rdfs:label "mid-upper arm circumference datum" ;
  rdfs:comment "A length measurement datum that is the specified output of an assay measuring the length around an upper arm, taken midway along the upper arm."@en ;
  rdfs:subClassOf obo:IAO_0000408 .

obo:OBI_0001689 a rdfs:Class ;
  rdfs:label "cytochalasin-induced inhibition of actin polymerization assay" ;
  rdfs:comment "An assay which uses compound cytochalasin (CHEBI: 23528) to block actin polymerization-dependent cell motility (GO:0070358) and actin filament polymerization (GO:0030041)."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002482 a rdfs:Class ;
  rdfs:label "specimen harvest quantity"@en ;
  rdfs:comment "A scalar measurement datum that indicates the amount of specimen collected."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0002605 a rdfs:Class ;
  rdfs:label "cheek swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the cheek portion of the inside surface of a mouth."@en ;
  rdfs:subClassOf obo:OBI_0002607 .

obo:OBI_0000531 a rdfs:Class ;
  rdfs:label "Bruker CryoProbe" ;
  rdfs:comment "The Bruker BioSpin CryoProbe is a high-performance cryogenically cooled probe developed for high-resolution applications. It has improved signal/noise (S/N) ratios obtained by reducing the operating temperature of the coil and the pre-amplifier. As a result, the efficiency of the coil is improved and the noise of the coil and the pre-amplifier are reduced.The dramatic increase in the S/N ratio by a factor of 3-4, as compared to conventional probes, leads to a possible reduction in experiment time of up to 16 or a reduction in required sample concentration by a factor of up to 4. The CryoProbes possess key characteristics for NMR analysis:n   Significant S/N gains (with moderately salty samples also)n   Short pulse widthsn   Short ring down timesn   Linear behavior in power responsen   Gradient capabilityn   CryoProbes are available as Triple Resonance, Dual, Selective X Detection, MicroImaging, and Quad Nucleus Probes configurations at 400 MHz and highern   All high resolution probes have a lock circuitn   All high resolution probes have Z-gradient."@en ;
  rdfs:subClassOf obo:OBI_0000561 .

obo:PATO_0002027 a rdfs:Class ;
  rdfs:label "osmolality" ;
  rdfs:comment "A concentration quality inhering in a bearer by virtue of the bearer's amount of osmoles of solute per kilogram of solvent." ;
  rdfs:subClassOf obo:PATO_0000033 .

obo:OBI_0003652 a rdfs:Class ;
  rdfs:label "albumin-free serum" ;
  rdfs:comment "A blood serum specimen that contains no albumin."@en ;
  rdfs:subClassOf obo:OBI_0100017 .

obo:OBI_1110111 a rdfs:Class ;
  rdfs:label "environmental proximity to infectious agent"@en ;
  rdfs:comment "Is a process in which an infectious agent comes close enough to a potential host organism in its habitat that a contact can result"@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:CLO_0000001 a rdfs:Class ;
  rdfs:label "cell line cell" ;
  rdfs:comment """A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
""" ;
  rdfs:subClassOf obo:CL_0000010 .

obo:CHEBI_59052 a rdfs:Class ;
  rdfs:label "1,1-dihydroxy-3-ethoxy-2-butanone" ;
  rdfs:comment "A butanone derivative having two hydroxy substituents at the 1-position and an ethoxy substituent at the 3-position." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000367 a rdfs:Class ;
  rdfs:label "light emission function"@en ;
  rdfs:comment "A light emission function is an excitation function to excite a material to a specific excitation state that it emits light."@en ;
  rdfs:subClassOf obo:OBI_0000374 .

obo:OBI_0200177 a rdfs:Class ;
  rdfs:label "center calculation objective"@en ;
  rdfs:comment "A center calculation objective is a data transformation objective where the aim is to calculate the center of an input data set."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002645 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific tolerance induction resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that uses a tolerance induction intervention experiment after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0001324 , obo:OBI_0001488 , obo:OBI_0002676 .

obo:OBI_0002111 a rdfs:Class ;
  rdfs:label "enhanced cross-linking immunoprecipitation high-throughput sequencing assay" ;
  rdfs:comment "An iCLIP assay that is enhanced to robustly identify protein-RNA interactions with high efficiency through improvements in library preparation of RNA fragments."@en ;
  rdfs:subClassOf obo:OBI_0002043 .

obo:CHEBI_33252 a rdfs:Class ;
  rdfs:label "atomic nucleus" ;
  rdfs:comment "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." ;
  rdfs:subClassOf obo:CHEBI_36342 .

obo:OBI_0000551 a rdfs:Class ;
  rdfs:label "needle assembly" ;
  rdfs:comment "The needle assembly attached to the autosampler, comprises the injector needle that feeds a sample or carrier gas into the inlet"@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0003089 a rdfs:Class ;
  rdfs:label "bulk assay for transposase-accessible chromatin using sequencing" ;
  rdfs:comment "An assay for transposase-accessible chromatin using sequencing in which the sample that is sequenced is derived from a collection of cells, such as a tissue sample or entire cell culture, and therefore provides results representative of the aggregate of sample cells."@en ;
  rdfs:subClassOf obo:OBI_0002039 .

obo:OBI_0001145 a rdfs:Class ;
  rdfs:label "3D structure determination of bound molecular complex assay" ;
  rdfs:comment "A 3D molecular structure determination assay in which a complex of 2 or more molecular enties is characterized which provides information on their binding configuration."@en ;
  rdfs:subClassOf obo:OBI_0003117 .

obo:OBI_0002540 a rdfs:Class ;
  rdfs:label "coronary artery specimen" ;
  rdfs:comment "A specimen that is derived from coronary artery."@en ;
  rdfs:subClassOf obo:OBI_0001479 , obo:OBI_0002520 .

obo:OBI_0200143 a rdfs:Class ;
  rdfs:label "subgraph in-degree calculation"@en ;
  rdfs:comment "A network subgraph quality calculation in which an input data set describing subgraphs and directional relationship edges between subgraphs and other network objects is used to enumerate the number of unique relationships pointing into an individual subgraph."@en ;
  rdfs:subClassOf obo:OBI_0200137 .

obo:OBI_0003714 a rdfs:Class ;
  rdfs:label "reproductive assay" ;
  rdfs:comment "A physical examination of an organism that provides information about some reproductive process in that organism."@en ;
  rdfs:subClassOf obo:OBI_0002441 .

obo:OBI_0000685 a rdfs:Class ;
  rdfs:label "creating a mixture of molecules in solution" ;
  rdfs:comment "is a process with the objective to prepare a liquid solution of one or more chemicals at desired concentrations."@en ;
  rdfs:subClassOf obo:OBI_0000652 .

obo:OBI_0001491 a rdfs:Class ;
  rdfs:label "binding assay using radioactivity detection" ;
  rdfs:comment "A binding assay that uses radioactivity detection as an indicator of binding."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0000599 a rdfs:Class ;
  rdfs:label "tecmag NMR console" ;
  rdfs:comment "An NMR console manufactured by tecmac."@en ;
  rdfs:subClassOf obo:OBI_0000499 .

obo:CL_0000128 a rdfs:Class ;
  rdfs:label "oligodendrocyte" ;
  rdfs:comment "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." ;
  rdfs:subClassOf obo:CL_0002319 .

obo:OBI_0001929 a rdfs:Class ;
  rdfs:label "mass value specification" ;
  rdfs:comment "A value specification that specifies the mass of some thing."@en ;
  rdfs:subClassOf obo:OBI_0001931 .

obo:OBI_0002186 a rdfs:Class ;
  rdfs:label "electroencephalography" ;
  rdfs:comment "An extracellular electrophysiology assay where electrodes are mounted outside the brain (either on the surface of the scalp on onto the brain surface itself during surgery) to measure the electrical field over the external surface."@en ;
  rdfs:subClassOf obo:OBI_0000454 .

obo:OBI_0200166 a rdfs:Class ;
  rdfs:label "data transformation objective"@en ;
  rdfs:comment "An objective specification to transformation input data into output data"@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0500019 a rdfs:Class ;
  rdfs:label "self vs self design" ;
  rdfs:comment "A study design that investigates variance and error estimates in the experimental system, and is where the same extract is compared."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001373 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-8 production by T cells" ;
  rdfs:comment "A process of interleukin-8 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032637 , obo:OBI_0001193 .

obo:OBI_0001812 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-23 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-23 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001363 .

obo:UBERON_0000945 a rdfs:Class ;
  rdfs:label "stomach" ;
  rdfs:comment "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0001398 a rdfs:Class ;
  rdfs:label "protein and DNA interaction identification objective"@en ;
  rdfs:comment "A sequence feature identification objective that aims to characterize the interactions between protein and DNA which includes identification of transcription factor binding sites."@en ;
  rdfs:subClassOf obo:OBI_0000113 .

obo:OBI_2100250 a rdfs:Class ;
  rdfs:label "POC chem8 arterial blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in arterial blood as part of a POC chem8 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0003354 a rdfs:Class ;
  rdfs:label "raw magnetic resonance image data set" ;
  rdfs:comment "An image data set that is the direct output of an magnetic resonance imaging assay and whose values encode spatial frequencies produced by the NMR or MRI instrument."@en ;
  rdfs:subClassOf obo:OBI_0003328 , obo:OBI_0003331 .

obo:OBI_0002736 a rdfs:Class ;
  rdfs:label "organism detection by cross mating assay" ;
  rdfs:comment "An organism detection assay that is based on genetic crossings between specimens collected in the field to determine whether fertile progeny is produced."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0001002 a rdfs:Class ;
  rdfs:label "Faraday cage" ;
  rdfs:comment "A device formed by conducting material or by a mesh of such material, that blocks out external static electric fields."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_0000583 a rdfs:Class ;
  rdfs:label "refractive index detector" ;
  rdfs:comment "For analyzing non-UV absorbing substances, such as carbohydrates, lipids and polymers. This is also the detector of choice for gel permeation chromatography. The refractive index detector is one of the least sensitive LC detectors. It is very sensitive to changes in ambient temperature, pressure changes, flow-rate changes and can not be used for gradient elution. Despite these many disadvantages, this detector is extremely useful for detecting those compounds that are nonionic, do not adsorb in the UV, and do not fluoresce. There are many optical systems used in refractive index detectors but one of the most common is the differential refractive index detector."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0200151 a rdfs:Class ;
  rdfs:label "exponential base"@en ;
  rdfs:comment "The exponential base is a feature of an exponential function which is defined in http://en.wikipedia.org/wiki/Exponential_function. Its value can be any positive real number (typically different from 1)."@en ;
  rdfs:subClassOf obo:OBI_0200140 .

obo:OBI_0000292 a rdf:Property ;
  rdfs:label "has_feature_value"@en ;
  rdfs:comment "has_feature_value datatype property is used to describe the feature values which the feature class can contain, for example has_base can have feature values of nonNegativeInteger values."@en ;
  rdfs:domain obo:OBI_0200140 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0002599 a rdfs:Class ;
  rdfs:label "swab specimen" ;
  rdfs:comment "A specimen that is stored on a swab as the output of a collecting specimen with swab process."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0002063 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific granzyme A release by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects epitope specific granzyme A release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001809 , obo:OBI_0003115 .

obo:OBI_0003274 a rdfs:Class ;
  rdfs:label "virus in lung datum" ;
  rdfs:comment "A lung microbiology datum that is about a virus."@en ;
  rdfs:subClassOf obo:OBI_0003256 .

obo:OBI_0000848 a rdfs:Class ;
  rdfs:label "polyA RNA extraction" ;
  rdfs:comment "A RNA extraction process typically involving the use of poly dT oligomers in which the desired output material is polyA RNA."@en ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBI_0002527 a rdfs:Class ;
  rdfs:label "pancreas specimen" ;
  rdfs:comment "A specimen that is derived from pancreas."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001453 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific lymphotoxin A production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects lymphotoxin A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001327 , obo:OBI_0001385 .

obo:OBI_0001611 a rdfs:Class ;
  rdfs:label "obsolete purified MHC direct binding assay" ;
  rdfs:comment "direct binding assay measuring MHC ligand binding using MHC derived from a purified MHC molecule preparation"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001626 a rdfs:Class ;
  rdfs:label "Bioinformatics Resource Center"@en ;
  rdfs:comment "An organization that  is one of the Internet-based research centers established and funded by NIAID (the National Institute of Allergy and Infectious Diseases). The Bioinformatics Resource Centers (BRCs) were formed in response to the threats posed by emerging and re-emerging pathogens, particularly CDC Category A, B, and C pathogens, and their potential use in bioterrorism. The intention of NIAID in funding these bioinformatics centers is to assist researchers involved in the experimental characterization of such pathogens and the formation of drugs, vaccines, or diagnostic tools to combat them."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0000625 a rdfs:Class ;
  rdfs:label "JEOL ECX NMR spectrometer" ;
  rdfs:comment "The ECX series of NMR spectrometers is designed for any laboratory needing an easy-to-use, reliable, routine NMR system. The ECX NMR series is available from 300 to 500 MHz. The console is designed around a modular, digital NMR electronics chassis controlled by an intelligent acquisition computer. For unprecedented flexibility, the JEOL NMR system offers a Windows XP, Mac OSX or LINUX. Both the workstation and spectrometer may be connected to a standard network, allowing seamless remote operation anywhere in the world."@en ;
  rdfs:subClassOf obo:OBI_0000600 .

obo:OBI_0001715 a rdfs:Class ;
  rdfs:label "obsolete B cell epitope competitive binding assay" ;
  rdfs:comment "A competitive inhibition of binding assay using a assay"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001957 a rdfs:Class ;
  rdfs:label "hardware testing design" ;
  rdfs:comment "A study design that aims to compare different types of hardware for performance, reproducibility, accuracy and precision."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0600050 a rdfs:Class ;
  rdfs:label "specific enzymatic cleavage"@en ;
  rdfs:comment "an enzymatic cleavage that uses an enzyme with a strong affinity for specific cleavage sites in the input material"@en ;
  rdfs:subClassOf obo:OBI_0000231 .

obo:OBI_0001537 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001988 .

obo:OBI_0000636 a rdfs:Class ;
  rdfs:label "acquisition computer" ;
  rdfs:comment "A Computer used for NMR, can be divided into central processing unit (CPU), consisting of instruction, interpretation and arithmetic unit plus fast access memory, and peripheral devices such as bulk data storage and input and output devices (including, via the interface, the spectrometer). Under software control, the computer controls the RF pulses and gradients necessary to acquire data, and process the data to produce spectra or images. Note that devices such as the spectrometer may themselves incorporate small computers."@en ;
  rdfs:subClassOf obo:OBI_0400107 .

obo:OBI_2100008 a rdfs:Class ;
  rdfs:label "lymphocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of lymphocytes"@en ;
  rdfs:subClassOf obo:OBI_0003024 .

obo:OBI_0001496 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-22 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001217 .

obo:OBI_0001760 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-X-C motif) ligand 13 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-X-C motif) ligand 13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001779 .

obo:CHEBI_39127 a rdfs:Class ;
  rdfs:label "magnesium cation" ;
  rdfs:comment "Any magnesium ion that is positively charged." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003235 a rdfs:Class ;
  rdfs:label "lung assay" ;
  rdfs:comment "An assay that has a lung specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003292 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific granulysin release by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects epitope specific granulysin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001810 , obo:OBI_0003115 .

obo:OBI_0001238 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-9 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001253 .

obo:OBI_0001935 a rdfs:Class ;
  rdfs:label "predicted mass value" ;
  rdfs:comment "A predicted value where the prediction specifies the mass of some thing."@en ;
  rdfs:subClassOf obo:OBI_0001934 .

obo:OBI_0003456 a rdfs:Class ;
  rdfs:label "in vivo challenge" ;
  rdfs:comment "The administration of a challenge to a live host."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0000807 a rdfs:Class ;
  rdfs:label "presentation of stimulus" ;
  rdfs:comment "A planned process with the objective to expose an organism to a stimulus."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003920 a rdfs:Class ;
  rdfs:label "point operation" ;
  rdfs:comment "An image transformation that modifies pixel values using a mathematical operation that could be independent of neighboring pixels or spatial location of those pixels. Produces a mathematically transformed image data set."@en ;
  rdfs:subClassOf obo:OBI_0003917 .

obo:OBI_0003259 a rdfs:Class ;
  rdfs:label "umbilical cord blood assay datum" ;
  rdfs:comment "A data entity that is the specified output of an umbilical cord blood assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 , obo:OBI_0003243 .

obo:OBI_0001119 a rdfs:Class ;
  rdfs:label "cell harvester" ;
  rdfs:comment "A device that is used to harvest cells from microplates and deposit samples on a filter mat. NOT AN INSTRUMENT?"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002810 a rdfs:Class ;
  rdfs:label "protective coverall" ;
  rdfs:comment "A personal protective clothing item which is a loose fitting coverall for ease of movement, with sleeves, full leggings and often a hood to cover the head. These can also include overshoe pieces to cover footwear and protect against contamination."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_0400012 a rdfs:Class ;
  rdfs:label "Bactiflow" ;
  rdfs:comment "A Bactiflow is a flow_cytometer_analyser manufactured by Chemunex SA. It is a cell counter for bacteria and other micro organisms. Bacteria are stained with a fluorochrome and the number of particles that fluoresce are counted. The system uses digital electronics, a single laser and a single detector. An ALS version is available as well - Automatic Labeling System. The Bactiflow is specialized cytometer used exclusively for counting microbes."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0002410 a rdfs:Class ;
  rdfs:label "menopausal status" ;
  rdfs:comment "An information content entity that indicates the state of a female's cessation of menstruation."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0000696 a rdfs:Class ;
  rdfs:label "AB SOLiD System" ;
  rdfs:comment "is a DNA sequencer which is manufactured by Applied Biosystems and which enable DNA sequencing by ligation"@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0002739 a rdfs:Class ;
  rdfs:label "organism detection by morphological examination assay" ;
  rdfs:comment "An organism detection assay that is based on examination of morphology and the use of specific taxonomic keys to determine the species of the specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0001237 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-21 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001853 a rdfs:Class ;
  rdfs:label "DNase I hypersensitive sites sequencing assay" ;
  rdfs:comment "An assay that identifies the location of regulatory regions, based on the genome-wide sequencing of regions super sensitive to cleavage by DNase I."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0400083 a rdfs:Class ;
  rdfs:label "photodiode" ;
  rdfs:comment "A photodiode is a semiconductor photodetector used to detect light and generate an electrical current. Typically used in forward scatter (FSC) detection. The photodiode collects the forward light scatter in a cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400082 .

obo:OBI_0002567 a rdfs:Class ;
  rdfs:label "sequence alignment" ;
  rdfs:comment "A data transformation in which one or more sequences (reads) are positioned on a reference sequence template (often a reference set of genes), according to the genetic base-pairing paradigm."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_0003884 a rdfs:Class ;
  rdfs:label "light sheet microscope" ;
  rdfs:comment "A microscope that uses illumination and detection objectives to image a sample illuminated with a thin sheet of laser light."@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:UBERON_0001621 a rdfs:Class ;
  rdfs:label "coronary artery" ;
  rdfs:comment "An artery that supplies the myocardium." ;
  rdfs:subClassOf obo:UBERON_0001637 .

obo:OBI_0200140 a rdfs:Class ;
  rdfs:label "mathematical feature"@en ;
  rdfs:comment "feature is a (parent_class) that describes a characteristic, trait or quality of a data transformation"@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0000118 a rdfs:Class ;
  rdfs:label "gene list"@en ;
  rdfs:comment "A data set of the names or identifiers of genes that are the outcome of an analysis or have been put together for the purpose of an analysis."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0400158 a rdfs:Class ;
  rdfs:label "digital-to-analog converter" ;
  rdfs:comment "A digital-to-analog_converter is an instrument that converts a finite resolution digital signal into an infinite resolution analog signal."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003636 a rdfs:Class ;
  rdfs:label "antibody purification of MHC class II protein complex" ;
  rdfs:comment "An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class II protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003615 .

obo:OBI_0002074 a rdfs:Class ;
  rdfs:label "assay measuring T cell epitope specific suppression in vitro" ;
  rdfs:comment "T cell epitope dependent biological activity assay that detects suppression of an in vitro response."@en ;
  rdfs:subClassOf obo:OBI_0002055 .

obo:OBI_0003000 a rdfs:Class ;
  rdfs:label "resting flight-capable arthropod specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process that occurs while an arthropod that is capable of flight is resting outdoors during a period of inactivity."@en ;
  rdfs:subClassOf obo:OBI_0002913 .

obo:OBI_0003644 a rdfs:Class ;
  rdfs:label "antibody purification of H2-IAg7 protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAg7 protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003642 , obo:OBI_0003643 .

obo:OBI_0001088 a rdfs:Class ;
  rdfs:label "tandem mass spectrometer" ;
  rdfs:comment "A mass spectrometer in which ions are subjected to two or more sequential stages of analysis (which may be separated spatially or temporally) according to the quotient mass/charge."@en ;
  rdfs:subClassOf obo:OBI_0000049 .

obo:UBERON_0012168 a rdfs:Class ;
  rdfs:label "umbilical cord blood" ;
  rdfs:comment "Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]." ;
  rdfs:subClassOf obo:UBERON_0013755 .

obo:OBI_0000921 a rdfs:Class ;
  rdfs:label "labeled RNA extract" ;
  rdfs:comment "a labeled specimen that is the output of a labeling process and has grain labeled RNA to be able to detect RNA in future experiments."@en ;
  rdfs:subClassOf obo:OBI_0001143 .

obo:OBI_0003220 a rdfs:Class ;
  rdfs:label "fatty acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of fatty acid"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001356 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interferon-beta production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interferon-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001390 .

obo:OBI_0002469 a rdfs:Class ;
  rdfs:label "base calling application"@en ;
  rdfs:comment "A base-calling application that implments a base-calling algorithm to convert BCL (binary base call) files, (e.g., those generated by Illumina sequencing systems) to standard FASTQ file formats for downstream analysis."@en ;
  rdfs:subClassOf obo:IAO_0000594 .

obo:PR_000050219 a rdfs:Class ;
  rdfs:label "alanine aminotransferase" ;
  rdfs:comment "A protein that is a translation product of the human GPT or GPT2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_2100074 a rdfs:Class ;
  rdfs:label "CBC venous blood RBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of RBCs in venous blood as part of a CBC order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0002970 a rdfs:Class ;
  rdfs:label "multiplex bead-based protein state immunoassay" ;
  rdfs:comment "A type of protein state assay in which antibodies attached to different colored beads and fluorescent reporter dye labels are used in a multiplexed mixture to assay for proteins in specific states."@en ;
  rdfs:subClassOf obo:OBI_0002953 .

obo:OBI_0003815 a rdfs:Class ;
  rdfs:label "organism development assay in late embryo based on examination of anatomical system" ;
  rdfs:comment "An organism development assay in late embryo that evaluates the anatomical system of the organism"@en ;
  rdfs:subClassOf obo:OBI_0003767 .

obo:OBI_0001696 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection based on survival" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from other challenge using survival."@en ;
  rdfs:subClassOf obo:OBI_0001189 , obo:OBI_0003467 .

obo:OBI_0001946 a rdfs:Class ;
  rdfs:label "forward PCR primer"@en ;
  rdfs:comment "A short oligonucleotide complementary to target DNA (5'->3' on plus strand) that acts as the leader for DNA extension in a PCR reaction. The polymerase starts replication at the 3'-end of the primer, and copies the opposite strand. A primer is characterized by its 'melting temperature' (Tm) and pairs of primers should have similar Tm."@en ;
  rdfs:subClassOf obo:CHEBI_16991 , obo:OBI_0001879 .

obo:OBI_0003625 a rdfs:Class ;
  rdfs:label "antibody purification of cattle MHC class I protein complex" ;
  rdfs:comment "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class I protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003616 , obo:OBI_0003635 .

obo:OBI_0003191 a rdfs:Class ;
  rdfs:label "manual hematocrit assay" ;
  rdfs:comment "A hematocrit assay that measures the percentage of erythrocytes in a specimen by manual processes."@en ;
  rdfs:subClassOf obo:OBI_0003018 .

obo:OBI_0000129 a rdfs:Class ;
  rdfs:label "calibration substance role"@en ;
  rdfs:comment "A reference substance role that is realized when characteristics or responses elicited by the bearer are used to ensure an instrument is within protocol specification of accuracy or performance"@en ;
  rdfs:subClassOf obo:OBI_0000025 .

obo:OBI_0002670 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific helper T cell enhancement of a T cell mediated immune response resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance a T cell response after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001263 , obo:OBI_0002676 .

obo:OBI_0003660 a rdfs:Class ;
  rdfs:label "in vitro CRISPR screen using single-cell RNA-seq" ;
  rdfs:comment "An in vitro CRISPR screen assay that uses single-cell RNA-Seq to detect induced changes in gene expression."@en ;
  rdfs:subClassOf obo:OBI_0003659 .

obo:OBI_0002679 a rdfs:Class ;
  rdfs:label "vacuum-assisted biopsy needle" ;
  rdfs:comment "A core biopsy needle integrated with a vacuum system which facilitates the collection of specimen material."@en ;
  rdfs:subClassOf obo:OBI_0000436 .

obo:OBI_0001930 a rdfs:Class ;
  rdfs:label "categorical value specification" ;
  rdfs:comment "A value specification that is specifies one category out of a fixed number of nominal categories"@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:UBERON_0001557 a rdfs:Class ;
  rdfs:label "upper respiratory tract" ;
  rdfs:comment "The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_2100395 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid monocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of monocytes in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003025 , obo:OBI_0003232 .

obo:OBI_1110159 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-13 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001251 .

obo:OBI_0003563 a rdfs:Class ;
  rdfs:label "intracranial administration" ;
  rdfs:comment "An administration of a substance into the cranium of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:GO_0032626 a rdfs:Class ;
  rdfs:label "interleukin-22 production" ;
  rdfs:comment "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0200024 a rdfs:Class ;
  rdfs:label "loess group transformation"@en ;
  rdfs:comment "A loess group transformation is a loess transformation where the input is partitioned into groups and for each group a loess fitting is performed, utilizing a subset of (or possibly all of) the data points in that group. Thus, a collection of loess curves y=f_i(x) is generated, one per group. Each (x, y) in the input is transformed into (x, y-f_i(x)), where f_i(x) is the curve corresponding to the group to which that data point belongs."@en ;
  rdfs:subClassOf obo:OBI_0200071 .

obo:OBI_0600009 a rdfs:Class ;
  rdfs:label "exposure of material to environment"@en ;
  rdfs:comment "a planned process in which an input material is exposed to a defined set of conditions in a controlled environment. The environment is a specified input."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001592 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring half maximal effective concentration [EC50] to determine direct binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures half maximal effective concentration (EC50) to detect direct binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001991 .

obo:OBI_1110191 a rdfs:Class ;
  rdfs:label "epitope specific IL-13 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-13 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032616 , obo:OBI_0001193 .

obo:OBI_0001447 a rdfs:Class ;
  rdfs:label "epitope specific macrophage inflammatory protein-1 gamma production by T cells" ;
  rdfs:comment "A process of macrophage inflammatory protein-1 gamma production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071607 , obo:OBI_0001193 .

obo:OBI_0000915 a rdfs:Class ;
  rdfs:label "freezing storage" ;
  rdfs:comment "A storage process in temperature that maintenance the frozen status of the stored entities."@en ;
  rdfs:subClassOf obo:OBI_0302893 .

obo:OBI_0003793 a rdfs:Class ;
  rdfs:label "bacterial lipopolysaccharide detection in plasma assay" ;
  rdfs:comment "An analyte assay measuring bacterial lipopolysaccharide in a plasma sample."@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_0003281 a rdfs:Class ;
  rdfs:label "eukaryota in umbilical cord blood datum" ;
  rdfs:comment "An umbilical cord blood microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003260 , obo:OBI_0003263 .

obo:OBI_2000012 a rdfs:Class ;
  rdfs:label "umbilical cord blood specimen" ;
  rdfs:comment "A specimen that is derived from some umbilical cord blood"@en ;
  rdfs:subClassOf obo:OBI_0000655 , obo:OBI_2000013 .

obo:OBI_0001317 a rdfs:Class ;
  rdfs:label "flow cytometry assay measuring cell-cell binding of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A flow cytometry assay that measures the cell-cell binding of an epitope:MHC complex binding with a T cell receptor."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_1110124 .

obo:IAO_0000312 a rdfs:Class ;
  rdfs:label "publication about an investigation"@en ;
  rdfs:comment "A publication that is about an investigation"@en ;
  rdfs:subClassOf obo:IAO_0000311 .

obo:OBI_0001211 a rdfs:Class ;
  rdfs:label "ex vivo design" ;
  rdfs:comment "A study design where all or part of an organism is removed and studied in vitro, e.g. part of a mouse is removed and cultured in vitro. A cell culture with an established cell line is an in vitro experiment."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0000079 a rdfs:Class ;
  rdfs:label "culture medium"@en ;
  rdfs:comment "a processed material that provides the needed nourishment for microorganisms or cells grown in vitro."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0001526 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-17A production by T cells" ;
  rdfs:comment "A process of interleukin-17A production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0097087 , obo:OBI_1110193 .

obo:CL_0000560 a rdfs:Class ;
  rdfs:label "band form neutrophil" ;
  rdfs:comment "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." ;
  rdfs:subClassOf obo:CL_0000775 .

obo:OBI_1110039 a rdfs:Class ;
  rdfs:label "T2 cell line"@en ;
  rdfs:comment "A human T-B lymphoblastoid hybrid cell line"@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0003011 a rdfs:Class ;
  rdfs:label "iron assay" ;
  rdfs:comment "An analyte assay that measures the abundance of iron"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003619 a rdfs:Class ;
  rdfs:label "antibody purification of HLA protein complex with A24 serotype" ;
  rdfs:comment "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A24 serotype, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003617 .

obo:OBI_2100305 a rdfs:Class ;
  rdfs:label "ABG/electrolytes arterial blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a ABG/electrolytes order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_2100376 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood temperature assay" ;
  rdfs:comment "An assay that measures temperature in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0003540 a rdfs:Class ;
  rdfs:label "tandem mass spectrometry assay" ;
  rdfs:comment "A mass spectrometry assay that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules)."@en ;
  rdfs:subClassOf obo:OBI_0000470 .

obo:OBI_0001223 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-1 beta production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-1 beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001449 , obo:OBI_0003115 .

obo:OBI_0001733 a rdfs:Class ;
  rdfs:label "calorimetry assay measuring the association constant [KA] of a B cell epitope:antibody complex" ;
  rdfs:comment "A calorimetric binding assay that measures the association constant [KA] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001634 , obo:OBI_0001719 .

obo:OBI_2100335 a rdfs:Class ;
  rdfs:label "manual differential bodily fluid macrophage count assay" ;
  rdfs:comment "A cytometry assay that measures the count of macrophages in bodily fluid as part of a manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003027 .

obo:OBI_0001633 a rdfs:Class ;
  rdfs:label "purified material" ;
  rdfs:comment "A material entity that is generated by a purification process in which an input material is separated to obtain a fraction with a higher concentration of a desired component"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:GO_0032905 a rdfs:Class ;
  rdfs:label "transforming growth factor beta1 production" ;
  rdfs:comment "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003130 a rdfs:Class ;
  rdfs:label "irradiation mutagenesis" ;
  rdfs:comment "A form of random mutagenesis that produces a random mutation by exposing the organism to radiation."@en ;
  rdfs:subClassOf obo:OBI_0002620 .

obo:PATO_0001741 a rdfs:Class ;
  rdfs:label "radioactive" ;
  rdfs:comment "A radiation quality inhering in bearer by virtue of the bearer's exhibiting or being caused by radioactivity." ;
  rdfs:subClassOf obo:PATO_0001740 .

obo:UBERON_0013757 a rdfs:Class ;
  rdfs:label "capillary blood" ;
  rdfs:comment "A blood that is part of a capillary." ;
  rdfs:subClassOf obo:UBERON_0000178 .

obo:OBI_2100126 a rdfs:Class ;
  rdfs:label "hemoglobin oxygen saturation arterial blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in arterial blood as part of a hemoglobin oxygen saturation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:GO_0032619 a rdfs:Class ;
  rdfs:label "interleukin-16 production" ;
  rdfs:comment "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003889 a rdfs:Class ;
  rdfs:label "I5 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using indoline-5-carboxylic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0003663 a rdfs:Class ;
  rdfs:label "Illumina NovaSeq X" ;
  rdfs:comment "A DNA sequencer with three flow cell types manufactured by Illumina. The NovaSeq X provides an output of up to 8 Tb (26-52 billion reads per run). The sequencer utilizes XLEAP-SBS chemistry, an advanced version of Illumina's sequencing by synthesis (SBS) technology, which enables faster and more accurate sequencing."@en ;
  rdfs:subClassOf obo:OBI_0003685 .

obo:OBI_0200021 a rdfs:Class ;
  rdfs:label "linlog transformation"@en ;
  rdfs:comment "A linlog transformation is a data transformation, described in PMID 16646782, whose input is a matrix [y_ik] and whose output is a matrix obtained by applying formula (9) of this paper, where values below an appropriately determined threshold (dependent on the row i) are transformed via a polynomial of degree 1, and values above this threshold are transformed via a logarithm."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_1110122 a rdfs:Class ;
  rdfs:label "pathologic process"@en ;
  rdfs:comment "abnormal, harmful processes caused by or associated with a disease"@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003455 a rdfs:Class ;
  rdfs:label "tumor challenge" ;
  rdfs:comment "The administration of a malignant cell to a host."@en ;
  rdfs:subClassOf obo:OBI_0003456 .

obo:OBI_0200170 a rdfs:Class ;
  rdfs:label "averaging data transformation"@en ;
  rdfs:comment "An averaging data transformation is a data transformation that has objective averaging."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0003568 a rdfs:Class ;
  rdfs:label "skin scarification administration" ;
  rdfs:comment "An intraepidermal administration in which the skin is scratched before the substance is administered to the skin."@en ;
  rdfs:subClassOf obo:OBI_0003564 .

obo:OBI_0003580 a rdfs:Class ;
  rdfs:label "nasal aspirate microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a nasal aspirate specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0001302 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects macrophage inflammatory protein-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001333 .

obo:CHEBI_27889 a rdfs:Class ;
  rdfs:label "lead(0)" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000479 a rdfs:Class ;
  rdfs:label "solid NMR probe" ;
  rdfs:comment "An NMR probe that is designed to hold a solid sample."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_0001094 a rdfs:Class ;
  rdfs:label "plate shaker" ;
  rdfs:comment "A device that provides shaking motion for microplates."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002747 a rdfs:Class ;
  rdfs:label "passage process"@en ;
  rdfs:comment "A material processing that consists of first growing an organism in an environmental system and then removing the organism to be grown in another environmental system, a process which may be repeated with the objective of altering the organism or increasing its number."@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:COB_0000502 a rdfs:Class ;
  rdfs:label "characteristic"@en .

obo:OBI_2100084 a rdfs:Class ;
  rdfs:label "liver evaluation venous blood alanine aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a liver evaluation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100016 .

obo:OBI_2000003 a rdfs:Class ;
  rdfs:label "throat specimen" ;
  rdfs:comment "A specimen that is derived from some throat"@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100233 a rdfs:Class ;
  rdfs:label "chem11 venous blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_0002764 a rdfs:Class ;
  rdfs:label "single-cell ATAC-seq" ;
  rdfs:comment "An ATAC assay designed to robustly map the accessible genome of individual cells, using sequencing integrated into a programmable microfluidics platform, in order to provide insights into cell-to-cell variation in accessibility profiles."@en ;
  rdfs:subClassOf obo:OBI_0002039 .

obo:OBI_0000416 a rdfs:Class ;
  rdfs:label "cloning insert role"@en ;
  rdfs:comment "cloning insert role is a role which inheres in DNA or RNA and is realized by the process of being inserted into a cloning vector in a cloning process."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000269 a rdfs:Class ;
  rdfs:label "number of lost events computer"@en ;
  rdfs:comment "A measurement datum recording the number of measurement events lost due to overloading of the analysis chip in a flow cytometer instrument. The datum has a qualitative role"@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0002634 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific disease exacerbation resulting from the adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that uses a disease exacerbation in vivo intervention experiment after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001188 , obo:OBI_0001711 , obo:OBI_0002677 .

obo:OBI_1110047 a rdfs:Class ;
  rdfs:label "cultured CD3+ T cell population"@en ;
  rdfs:comment "A T cell population characterized by expressing the CD3 molecule on its surface."@en ;
  rdfs:subClassOf obo:OBI_0001875 .

obo:GO_0048871 a rdfs:Class ;
  rdfs:label "multicellular organismal-level homeostasis" ;
  rdfs:comment "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0002940 a rdfs:Class ;
  rdfs:label "resting box trap" ;
  rdfs:comment "An arthropod trap that consists of a box that is open on one end. The placement of the box and modifications to it are done in such a way that it becomes attractive to an arthropod as a place to rest during a period of inactivity."@en ;
  rdfs:subClassOf obo:OBI_0002939 .

obo:OBI_0000722 a rdfs:Class ;
  rdfs:label "paired-end library" ;
  rdfs:comment "is a collection of short paired tags from the two ends of DNA fragments are extracted and covalently linked as ditag constructs"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0001018 a rdfs:Class ;
  rdfs:label "Rhodium DNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using Rhodium as reagent and chemical probe."@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0002127 a rdfs:Class ;
  rdfs:label "single cell specimen" ;
  rdfs:comment "A cell specimen that contains only one cell."@en ;
  rdfs:subClassOf obo:OBI_0001468 .

obo:OBI_2100352 a rdfs:Class ;
  rdfs:label "bodily fluid triglyceride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of triglyceride in bodily fluid"@en ;
  rdfs:subClassOf obo:OBI_2100029 .

obo:OBI_0400113 a rdfs:Class ;
  rdfs:label "oligonucleotide synthesizer" ;
  rdfs:comment "An instrument used to chemically synthesize oligonucleotides."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_0002782 a rdfs:Class ;
  rdfs:label "obsolete_upper respiratory specimen" ;
  rdfs:comment "A specimen that is derived from the upper respiratory tract"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0400020 a rdfs:Class ;
  rdfs:label "cell sorter collection tube" ;
  rdfs:comment "Part of the fluidics subsystem. The collection tube is a vessel for capturing cells of interest that have been identified by a sorter. The collection tube is the end location of sorted cells."@en ;
  rdfs:subClassOf obo:OBI_0000836 .

obo:GO_0097087 a rdfs:Class ;
  rdfs:label "interleukin-17A production" ;
  rdfs:comment "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032620 .

obo:OBI_0000516 a rdfs:Class ;
  rdfs:label "NMR probe" ;
  rdfs:comment "Part of an NMR instrument that detects the signals emitted from a sample. No single probe can perform the full range of experiments, and probes that are designed to perform more than one type of measurement usually suffer from performance compromises. The probe represents a rather fragile single point of failure that can render an NMR system completely unusable if the probe is dropped or otherwise damaged. Probes are usually characterised by Sample diameter and Frequency.n  alt The instrument that transmits and receives radiofrequency to and from the NMR sample."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0400080 a rdfs:Class ;
  rdfs:label "optical subsystem" ;
  rdfs:comment "A device or part of a device that deals with the behavior and properties of light and the interaction of light with matter. Commonly optical subsystems consist of an excitation optics and collection optics. The excitation optics of a flow cytometer optical subsystem consist of the laser and lenses that are used to shape and focus the laser beam. The collections optics consist of a collection lens to collect light emitted from the particle laser beam interaction and a system of optical mirrors and filters to route specified wavelengths of the collected light to designated optical detectors. The optical subsystem in a flow cytometer consists of the equipment used to irradiate particles, and collect the light either emitted or scattered by those particles."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0200035 a rdfs:Class ;
  rdfs:label "boostrapping"@en ;
  rdfs:comment "Bootstrapping is a statistical method for estimating the sampling distribution of a statistic by sampling with replacement from the original data, most often with the purpose of deriving robust estimates of standard errors and confidence intervals of a population parameter like a mean, median, proportion, odds ratio, correlation coefficient or regression coefficient"@en ;
  rdfs:subClassOf obo:OBI_0000792 .

obo:OBI_0002910 a rdfs:Class ;
  rdfs:label "arthropod resting outdoors on natural support specimen collection by aspiration" ;
  rdfs:comment "An arthropod resting outdoors specimen collection by aspiration that occurs while the arthropod rests on an unprocessed material such as a plant."@en ;
  rdfs:subClassOf obo:OBI_0002911 .

obo:GO_0002244 a rdfs:Class ;
  rdfs:label "hematopoietic progenitor cell differentiation" ;
  rdfs:comment "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." ;
  rdfs:subClassOf obo:GO_0030154 .

obo:OBI_0001378 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects chemokine (C-C motif) ligand 4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001345 .

obo:OBI_0002691 a rdfs:Class ;
  rdfs:label "arthropod meal of blood specimen" ;
  rdfs:comment "A specimen of the blood ingested by an arthropod."@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0000073 a rdfs:Class ;
  rdfs:label "sample preparation for assay"@en ;
  rdfs:comment "A sample_preparation_for_assay is a protocol_application including material_enrollments and biomaterial_transformations. definition_source: OBI."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:CHEBI_52673 a rdfs:Class ;
  rdfs:label "Alexa Fluor 555" ;
  rdfs:comment "A fluorescent dye of absorption wavelength 555 nm and emission wavelength 565 nm, derived from a 3,6-diaminoxanthene-4,5-disulfate." ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:OBI_0001904 a rdfs:Class ;
  rdfs:label "sequencing service"@en ;
  rdfs:comment "A service provides sequencing service which is the realization of some sequencing such as RNA and DNA sequencing in which the service provider role is realized."@en ;
  rdfs:subClassOf obo:OBI_0001528 , obo:OBI_0001547 .

obo:ENVO_00001998 a rdfs:Class ;
  rdfs:label "soil" ;
  rdfs:comment "An environmental material which is primarily composed of minerals, varying proportions of sand, silt, and clay, organic material such as humus, interstitial gases, liquids, and a broad range of resident micro- and macroorganisms."@en ;
  rdfs:subClassOf obo:ENVO_00010483 .

obo:OBI_0003658 a rdfs:Class ;
  rdfs:label "ring trial design" ;
  rdfs:comment "A study design with the objective of establishing the reproducibility of an experimental approach by performing experiments in different laboratories under the same conditions and comparing the experimental outcomes."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_2100317 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0002716 a rdfs:Class ;
  rdfs:label "insecticide resistance dose response by WHO paper kit assay" ;
  rdfs:comment "An insecticide resistance dose response assay using WHO paper kit."@en ;
  rdfs:subClassOf obo:OBI_0002708 .

obo:OBI_0000378 a rdfs:Class ;
  rdfs:label "filter function"@en ;
  rdfs:comment "A filter function is a function to prevent the flow of certain entities based on a quality or qualities of the entity while allowing entities which have different qualities to pass through"@en ;
  rdfs:subClassOf obo:OBI_0000372 .

obo:OBI_2100089 a rdfs:Class ;
  rdfs:label "basic metabolic panel venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a basic metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_1110091 a rdfs:Class ;
  rdfs:label "immune epitope carrier role"@en ;
  rdfs:comment "A role inhering in a material entity that is covalently bound to an epitope in order to increase the epitopes immunogenicity."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002105 a rdfs:Class ;
  rdfs:label "bio-layer interferometry assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A bio-layer interferometry assay that measures the dissociation constant [KD] of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001708 , obo:OBI_0002107 .

obo:OBI_0200162 a rdfs:Class ;
  rdfs:label "tail probability for the proportion of false positives correction method"@en ;
  rdfs:comment "A TPPFP correction method is a MTP that controls the probability that the proportion of false positives among all rejected hypotheses is no greater than a constant q, where q is between 0 and 1."@en ;
  rdfs:subClassOf obo:OBI_0200089 .

obo:OBI_0001986 a rdfs:Class ;
  rdfs:label "immunohistochemistry" ;
  rdfs:comment "An immunostaining assay to detect and potentially localize antigens within the cells of a tissue section."@en ;
  rdfs:subClassOf obo:OBI_0001632 .

obo:OBI_0002139 a rdfs:Class ;
  rdfs:label "volume value specification"@en ;
  rdfs:comment "A value specification that specifies the volume of some thing."@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_0002951 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based cell morphology assay" ;
  rdfs:comment "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures in order to determine cell morphology."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000215 a rdfs:Class ;
  rdfs:label "role of legally acceptable representative"@en ;
  rdfs:comment "a role which inheres in a human or organization who are able subject to applicable law to consent, on behalf of a prospective subject, to the subject`s participation in as clinical trial."@en ;
  rdfs:subClassOf obo:OBI_0000016 .

obo:OBI_2100328 a rdfs:Class ;
  rdfs:label "total bodily fluid protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in bodily fluid as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_2100023 .

obo:GO_0061028 a rdfs:Class ;
  rdfs:label "establishment of endothelial barrier" ;
  rdfs:comment "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." ;
  rdfs:subClassOf obo:GO_0048856 , obo:GO_0048869 .

obo:OBI_0002753 a rdfs:Class ;
  rdfs:label "PRO-cap" ;
  rdfs:comment "Precision nuclear run-on and sequencing to detect Pol II initiation sites"@en ;
  rdfs:subClassOf obo:OBI_0001177 , obo:OBI_0002692 .

obo:OBI_0000468 a rdfs:Class ;
  rdfs:label "protein column" ;
  rdfs:comment "A protein column is a chromatography column used for the separation of complex protein mixtures. Protein columns enable sample desalting, followed by chromatographic separation or fractionation of complex protein samples, e.g. immunodepleted serum or plasma proteins."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CHEBI_15956 a rdfs:Class ;
  rdfs:label "biotin" ;
  rdfs:comment "An organic heterobicyclic compound that consists of 2-oxohexahydro-1<em>H</em>-thieno[3,4-<em>d</em>]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins." ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:OBI_0003055 a rdfs:Class ;
  rdfs:label "blood specimen on filter paper" ;
  rdfs:comment "A blood specimen that is located on a filter paper."@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0003248 a rdfs:Class ;
  rdfs:label "urine microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a urine microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003247 .

obo:OBI_0003894 a rdfs:Class ;
  rdfs:label "BzCN RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using benzoyl cyanide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0000789 a rdfs:Class ;
  rdfs:label "survival rate" ;
  rdfs:comment "A measurement data that represents the percentage of people or animals in a study or treatment group who are alive for a given period of time after diagnosis or initiation of monitoring."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_2100109 a rdfs:Class ;
  rdfs:label "venous blood haptoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of haptoglobin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0002721 a rdfs:Class ;
  rdfs:label "insecticide resistance by nested polymerase chain reaction assay" ;
  rdfs:comment "An insecticide resistance by monitoring known mutations assay that detects gene mutation based on nested polymerase chain reaction technique."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0002696 .

obo:OBI_0001022 a rdfs:Class ;
  rdfs:label "gene dosage assay" ;
  rdfs:comment "An assay that measures changes in phenotype due to increased or decreased dosage of a single allele of a gene."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100107 a rdfs:Class ;
  rdfs:label "venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_0400005 a rdfs:Class ;
  rdfs:label "A10-Analyzer" ;
  rdfs:comment "A A10 is a flow_cytometer_analyser manufactured by Apogee. It uses an arc lamp as a light source, with choices of 75W Xe, 75W Xe/Hg or 100W Hg arc lamps. It has filters and collectors for up to three fluorescent parameters and two scatter parameters. It uses analog electronics. The A10 can be used for measuring the properties of individual cells."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0003050 a rdfs:Class ;
  rdfs:label "Centers for Disease Control and Prevention gravid trap" ;
  rdfs:comment "A gravid trap that consists of a pan holding a hay infusion, motorized fan, and collection bag. This trap is designed to attract gravid female arthropods to the infused material, which would serve as an oviposition medium, and then draw them into the bag with the current generated by the fan."@en ;
  rdfs:subClassOf obo:OBI_0002929 .

obo:OBI_0000741 a rdfs:Class ;
  rdfs:label "topologically preserved clustered data set" ;
  rdfs:comment "A clustered data set in which the topology, i.e. the spatial properties between data points, is preserved from the original input data from which it was derived."@en ;
  rdfs:subClassOf obo:OBI_0000648 .

obo:OBI_0000569 a rdfs:Class ;
  rdfs:label "mass selective detector" ;
  rdfs:comment "A mass selective detector is a GC detector that uses mass spectrometry. It is based upon the ionization of solute molecules in the ion source and the separation of the ions generated on the basis of their mass/charge ratio by an analyzer unit. This may be a magnetic sector analyzer, a quadruple mass filter, or an ion trap. Ions are detected by a dynode electron multiplier."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:COB_0000020 a rdfs:Class ;
  rdfs:label "obsolete subcellular structure" .

obo:OBI_0001678 a rdfs:Class ;
  rdfs:label "epitope specific granzyme A production by T cells" ;
  rdfs:comment "A process of granzyme A production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0035746 .

obo:OBI_0001250 a rdfs:Class ;
  rdfs:label "obsolete intracellular material detection by flow cytometry assay  of epitope specific cytotoxic T cell degranulation" ;
  rdfs:comment "An intracellular material detection by flow cytometry assay  that measures epitope specific cytotoxic T cell degranulation"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000867 a rdfs:Class ;
  rdfs:label "establishing cancer cell line" ;
  rdfs:comment "is a planned process in which the objective is to generate a cell line from a natural population of cancer cells which are already immortal"@en ;
  rdfs:subClassOf obo:OBI_0001867 .

obo:OBI_0000897 a rdfs:Class ;
  rdfs:label "DEPC structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay which determines nucleic acid secondary structure at a nucleotide resolution scale using DEPC as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001007 a rdfs:Class ;
  rdfs:label "image creation" ;
  rdfs:comment "A planned process that captures an image of an object."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002680 a rdfs:Class ;
  rdfs:label "pseudovirus entry assay" ;
  rdfs:comment "An assay that measures the entry in target cells of reporter viral particles that express an envelope protein of a different virus of interest."@en ;
  rdfs:subClassOf obo:OBI_0001187 .

obo:UBERON_0001830 a rdfs:Class ;
  rdfs:label "minor salivary gland" ;
  rdfs:comment "One of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands[MP]." ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:CHEBI_29101 a rdfs:Class ;
  rdfs:label "sodium(1+)" ;
  rdfs:comment "A monoatomic monocation obtained from sodium." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003111 a rdfs:Class ;
  rdfs:label "SOMAscan assay" ;
  rdfs:comment "An analyte assay that uses aptamers to detect protein analytes in serum."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001691 a rdfs:Class ;
  rdfs:label "cellular structure feature identification objective"@en ;
  rdfs:comment "is an objective specification which aims to discover cellular structure properties"@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:CL_0000776 a rdfs:Class ;
  rdfs:label "immature neutrophil" ;
  rdfs:comment "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." ;
  rdfs:subClassOf obo:CL_0000775 .

obo:OBI_0001216 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001445 .

obo:OBI_0001797 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-9 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001253 , obo:OBI_0600031 .

obo:OBI_0003602 a rdfs:Class ;
  rdfs:label "quartz crystal microbalance assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A quartz crystal microbalance assay that measures the dissociation constant [KD] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001708 , obo:OBI_0003601 .

obo:OBI_0400110 a rdfs:Class ;
  rdfs:label "hybridization chamber" ;
  rdfs:comment "A device which is used to maintain constant contact of a liquid on an array.  This can be either a glass vial or slide."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0002709 a rdfs:Class ;
  rdfs:label "insecticide resistance time response assay" ;
  rdfs:comment "A direct insecticide resistance assay to determine resistance as a consequence of the time of exposure to insecticide."@en ;
  rdfs:subClassOf obo:OBI_0002705 .

obo:OBI_0000136 a rdfs:Class ;
  rdfs:label "incubator" ;
  rdfs:comment "A device in which environmental conditions (light, photoperiod, temperature, humidity, etc.) can be controlled"@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_2100398 a rdfs:Class ;
  rdfs:label "lipid panel reflex direct venous blood low density lipoprotein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of low density lipoprotein in venous blood as part of a Lipid panel reflex direct order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100032 .

obo:OBI_0001503 a rdfs:Class ;
  rdfs:label "MHC protein complex binding to ligand" ;
  rdfs:comment "The process in which a ligand binds to an MHC molecule to form a stable complex."@en ;
  rdfs:subClassOf obo:OBI_0001588 .

obo:OBI_0002487 a rdfs:Class ;
  rdfs:label "microraft" ;
  rdfs:comment "A material separation device also commerically known as Isoraft, that is used to isolate single cells."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_1110180 a rdfs:Class ;
  rdfs:label "3H-thymidine assay measuring epitope specific proliferation of T cells" ;
  rdfs:comment "A tritiated thymidine incorporation assay that detects T cell epitope specific proliferation in vitro."@en ;
  rdfs:subClassOf obo:OBI_0000669 , obo:OBI_0002071 .

obo:NCBITaxon_6656 a rdfs:Class ;
  rdfs:label "Arthropoda" ;
  rdfs:subClassOf obo:NCBITaxon_1206794 .

obo:OBI_2100052 a rdfs:Class ;
  rdfs:label "panel5 venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a panel5 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0001048 a rdfs:Class ;
  rdfs:label "digital camera" ;
  rdfs:comment "An image acquisition device that takes video or still photographs, or both, digitally by recording images via an electronic image sensor."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0002769 a rdfs:Class ;
  rdfs:label "karyotype information"@en ;
  rdfs:comment "A genetic characteristics information that is about the number and appearance of chromosomes in the nucleus of an eukaryotic cell."@en ;
  rdfs:subClassOf obo:OBI_0001404 .

obo:OBI_0500028 a rdfs:Class ;
  rdfs:label "exclusion criterion"@en ;
  rdfs:comment "an exclusion criterion (rule) is_a *eligibility criterion*  which defines and states a condition which, if met, makes an entity unsuitable for a given task or participation in a given process. For instance, in a study protocol, exclusion criteria indicate the conditions that prospective subjects SHOULD NOT meet to be eligible for participation in a study"@en ;
  rdfs:subClassOf obo:OBI_0500026 .

obo:OBI_0001941 a rdfs:Class ;
  rdfs:label "contig N50"@en ;
  rdfs:comment "N50 statistic computed for the contigs produced by the assembly process. A contig N50 is calculated by first ordering every contig by length from longest to shortest. Next, starting from the longest contig, the lengths of each contig are summed, until this running sum equals one-half of the total length of all contigs in the assembly. The contig N50 of the assembly is the length of the shortest contig in this list."@en ;
  rdfs:subClassOf obo:OBI_0001940 .

obo:CL_0002368 a rdfs:Class ;
  rdfs:label "respiratory tract epithelial cell" ;
  rdfs:comment "An epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:OBI_0001817 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-18 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-18 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001380 , obo:OBI_0600031 .

obo:OBI_0100035 a rdfs:Class ;
  rdfs:label "obsolete_immortal cell" ;
  rdfs:comment "a cell derived from a multicellular organism that has the potential to replicate indefinitely"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:IAO_0000104 a rdfs:Class ;
  rdfs:label "plan specification"@en ;
  rdfs:comment "A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0200154 a rdfs:Class ;
  rdfs:label "agglomerative hierarchical clustering"@en ;
  rdfs:comment "An agglomerative hierarchical clustering is a hierarchical clustering which starts with separate clusters and then successively combines these clusters until there is only one cluster remaining."@en ;
  rdfs:subClassOf obo:OBI_0200042 .

obo:OBI_0001543 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring equilibrium dissociation constant [KD] to determine direct binding of a purified-MHC:ligand complex approximated by EC50" ;
  rdfs:comment "A fluorescence detection assay that measures equilibrium dissociation constant (KD) to detect direct binding of a purified-MHC molecule with a ligand and provides EC50 values determined under assay conditions where the EC50 approximates a KD value."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001592 , obo:OBI_0001988 .

obo:OBI_2100330 a rdfs:Class ;
  rdfs:label "count bodily fluid cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of cells in bodily fluid as part of a count order"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:PR_000005794 a rdfs:Class ;
  rdfs:label "ceruloplasmin" ;
  rdfs:comment "A protein that is a translation product of the human CP gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:UBERON_0013755 a rdfs:Class ;
  rdfs:label "arterial blood" ;
  rdfs:comment "A blood that is part of a artery." ;
  rdfs:subClassOf obo:UBERON_0000178 .

obo:OBI_0002202 a rdfs:Class ;
  rdfs:label "GX" ;
  rdfs:comment "A cannot be assessed determination for histologic tumor grade."@en ;
  rdfs:subClassOf obo:OBI_0002200 .

obo:MRO_0001530 a rdfs:Class ;
  rdfs:label "HLA protein complex with A2 serotype" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:OBI_0000680 a rdfs:Class ;
  rdfs:label "whole organism preparation" ;
  rdfs:comment "A material entity which is the output of a process in which one or more whole organisms are prepared in a way to make it easier to study them, and in which the great majority of organismal parts are maintained"@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0001205 a rdfs:Class ;
  rdfs:label "cell component comparison design" ;
  rdfs:comment "A study design that compares samples from different cell components."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001763 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 22 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-C motif) ligand 22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001777 .

obo:OBI_0001559 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring half life to determine direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures half life to detect the direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001990 .

obo:OBI_2100114 a rdfs:Class ;
  rdfs:label "lipid panel venous blood cholesterol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of cholesterol in venous blood as part of a lipid panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100031 .

obo:CHEBI_10545 a rdfs:Class ;
  rdfs:label "electron" ;
  rdfs:comment "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." ;
  rdfs:subClassOf obo:CHEBI_36342 .

obo:OBI_0003490 a rdfs:Class ;
  rdfs:label "Panbio Dengue IgM capture ELISA kit" ;
  rdfs:comment "An assay kit that is manufactured by Abbott to test for IgM antibodies for Dengue with a two-plate protein microarray. One plate contains stabilized Dengue viruses 1 through 4, and the other plate contains anti-human IgM antibody."@en ;
  rdfs:subClassOf obo:OBI_0003369 .

obo:OBI_0003213 a rdfs:Class ;
  rdfs:label "phospholipid concentration assay" ;
  rdfs:comment "A phospholipid assay that measures the concentration of phospholipids in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003212 .

obo:OBI_0003551 a rdfs:Class ;
  rdfs:label "resting clay pot trap" ;
  rdfs:comment "A resting arthropod trap that consists of a container composed primarily of clay."@en ;
  rdfs:subClassOf obo:OBI_0002939 .

obo:OBI_0000158 a rdfs:Class ;
  rdfs:label "eSource document"@en ;
  rdfs:comment "an eSource document is a digital document consisting of a logical collection of Source data and other eSource documents that can be presented in an ordered way and capture the time of completion, change, and any signatures"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:UBERON_0002072 a rdfs:Class ;
  rdfs:label "hypodermis" ;
  rdfs:comment "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003761 a rdfs:Class ;
  rdfs:label "cell death assay detecting lactate dehydrogenase (LDH) release" ;
  rdfs:comment "A cell death assay that measures the release of intracellular LDH."@en ;
  rdfs:subClassOf obo:OBI_0003759 .

obo:OBI_0003100 a rdfs:Class ;
  rdfs:label "multiplexed ion beam imaging assay" ;
  rdfs:comment "A cytometry time of flight assay in which molecules of interest on or in cells are imaged through a system in which samples are labeled with multiple different rare-earth tagged antibodies. A primary ion beam is ued to rasterize sections under vacuum, releasing showers of secondary ions detected by cytometry time of flight mass spectrometry."@en ;
  rdfs:subClassOf obo:OBI_0002115 .

obo:OBI_0600024 a rdfs:Class ;
  rdfs:label "maintaining cell culture"@en ;
  rdfs:comment "A planned process with the objective to keep cells alive in a defined environment outside of an organism."@en ;
  rdfs:subClassOf obo:OBI_0000838 .

obo:OBI_0000443 a rdfs:Class ;
  rdfs:label "analyte assay" ;
  rdfs:comment "An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003759 a rdfs:Class ;
  rdfs:label "cell death assay" ;
  rdfs:comment "A cell viability assay which measures the number or proportion of dead cells in a population."@en ;
  rdfs:subClassOf obo:OBI_0003583 .

obo:UBERON_0001089 a rdfs:Class ;
  rdfs:label "sweat" ;
  rdfs:comment "Secretion produced by a sweat gland." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0003241 a rdfs:Class ;
  rdfs:label "endotracheal tube aspirate microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in an endotracheal aspirate specimen."@en ;
  rdfs:subClassOf obo:OBI_0003233 , obo:OBI_0003498 .

obo:OBI_0001279 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-22 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001217 .

obo:PATO_0001793 a rdfs:Class ;
  rdfs:label "right side of" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity." ;
  rdfs:subClassOf obo:PATO_0000140 .

obo:OBI_0000989 a rdfs:Class ;
  rdfs:label "PCR instrument" ;
  rdfs:comment "A device that is used to amplify a single or few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence."@en ;
  rdfs:subClassOf obo:OBI_0400116 .

obo:OBI_0003591 a rdfs:Class ;
  rdfs:label "chronic allograft damage index score"@en ;
  rdfs:comment "A clinical data item that quantifies the degree of tissue damage in biopsies taken from transplanted kidneys."@en ;
  rdfs:subClassOf obo:OGMS_0000123 .

obo:OBI_0002442 a rdfs:Class ;
  rdfs:label "hydroxyl-radical footprinting assay" ;
  rdfs:comment "A footprinting assay that uses the reaction of hydroxyl radicals with side-chain sites in molecules (proteins, DNA, etc)_ with the resultant mass shift demonstrating the site of modification, used to_ to asses the accessibility of that site."@en ;
  rdfs:subClassOf obo:OBI_0002162 .

obo:OBI_0002369 a rdfs:Class ;
  rdfs:label "clinical history devoid of cancer" ;
  rdfs:comment "A clinical history in which there was no diagnosis of cancer."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0200181 a rdfs:Class ;
  rdfs:label "center calculation data transformation"@en ;
  rdfs:comment "A center calculation data transformation is a data transformation that has objective of center calculation."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_2100242 a rdfs:Class ;
  rdfs:label "chem16 venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0002529 a rdfs:Class ;
  rdfs:label "pituitary gland specimen" ;
  rdfs:comment "A specimen that is derived from pituitary gland."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001622 a rdfs:Class ;
  rdfs:label "investigation title"@en ;
  rdfs:comment "A textual entity that denotes an investigation."@en ;
  rdfs:subClassOf obo:OBI_0001898 .

obo:OBI_0003329 a rdfs:Class ;
  rdfs:label "magnetic resonance imaging participant"@en ;
  rdfs:comment "The subject being scanned in an MRI study, and bearor of data derived from that study."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0000956 a rdfs:Class ;
  rdfs:label "cerebral cortex" ;
  rdfs:comment "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001099 a rdfs:Class ;
  rdfs:label "immunoblot scanner" ;
  rdfs:comment "A device that is used for the imaging of immunoblots."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0002936 a rdfs:Class ;
  rdfs:label "Onderstepoort Veterinary Institute light-suction trap" ;
  rdfs:comment "A light trap that is designed to use motorized suction to trap arthropods in a collection bag once they approach the attractant. The light is supplied by an 8 watt tube, and the fan providing the suction has an 11-centimeter diameter."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0000006 a rdfs:Class ;
  rdfs:label "role of being consumer safety officer"@en ;
  rdfs:comment "the role of a human being that is realized by enforcing regulations to ensure consumer safety"@en ;
  rdfs:subClassOf obo:OBI_0000273 .

obo:OBI_2100193 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0003152 a rdfs:Class ;
  rdfs:label "cholesterol concentration assay" ;
  rdfs:comment "A cholesterol assay that measures the concentration of cholesterol in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100031 .

obo:PATO_0000040 a rdfs:Class ;
  rdfs:label "distance" ;
  rdfs:comment "A quality that is the extent of space between two entities." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0003422 a rdfs:Class ;
  rdfs:label "enzymatic activity level assay" ;
  rdfs:comment "An assay in which the level of catalytic activity of an enzyme is determined."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000418 a rdfs:Class ;
  rdfs:label "measuring glucose concentration in blood serum assay" ;
  rdfs:comment "An assay that determines the concentration of glucose molecules in a blood serum sample"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0002500 a rdfs:Class ;
  rdfs:label "amniotic fluid specimen" ;
  rdfs:comment "A specimen that is derived from amniotic fluid."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0200199 a rdfs:Class ;
  rdfs:label "gas chromatography mass spectrometry" ;
  rdfs:comment """Gas chromatography mass spectrometry is a data transformation combining mass spectrometry and  
gas chromatography for the qualitative as well as quantitative  
determinations of compounds."""@en ;
  rdfs:subClassOf obo:OBI_0200085 .

obo:UBERON_0002116 a rdfs:Class ;
  rdfs:label "ileum" ;
  rdfs:comment "The portion of the small intestine that extends from the jejunum to the colon." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0000818 a rdfs:Class ;
  rdfs:label "calibration" ;
  rdfs:comment "A planned process with the objective to establish the relationship between data produced by a measurement device and physical qualities. This is done by using the measurement device under defined conditions, and either tuning it to adjust the measured output, or record the output and use it as a reference in future measurements."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003202 a rdfs:Class ;
  rdfs:label "leptin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of leptin"@en ;
  rdfs:subClassOf obo:OBI_2100023 .

obo:OBI_0001297 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-10 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001209 , obo:OBI_0003115 .

obo:VO_0000002 a rdfs:Class ;
  rdfs:label "vaccination" ;
  rdfs:comment "Process of administering a vaccine in vivo to a recipient (e.g., a human), with the intent to invoke a protective or therapeutic adaptive immune response." ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0003822 a rdfs:Class ;
  rdfs:label "radial glial migration assay" ;
  rdfs:comment "A cell migration assay that measures migration of a radial glia cell"@en ;
  rdfs:subClassOf obo:OBI_0003820 .

obo:OBI_2100327 a rdfs:Class ;
  rdfs:label "venous blood parathyroid hormone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of parathyroid hormone in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OMRSE_00000012 a rdfs:Class ;
  rdfs:label "health care provider role"@en ;
  rdfs:comment "A health care role inhering in an organization or human being that is realized by a process of providing health care services to an organism."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001474 a rdfs:Class ;
  rdfs:label "lowess group transformation"@en ;
  rdfs:comment "A lowess transformation where a potentially different normalization curve is generated and used for two or more groups (delineated by some criteria); criteria could include blocks (e.g. print-tip groups) on an array, or the day on which mass spectrometry was performed."@en ;
  rdfs:subClassOf obo:OBI_0001477 .

obo:OBI_0400140 a rdfs:Class ;
  rdfs:label "gel tank" ;
  rdfs:comment "A device which holds a gel and running buffers to allow electrophoresis to be performed. A gel tank has the function to contain and to control the contained environment and transfer energy from an energy supply through the running buffers to the gel matrix and the material with charged molecules in an electric field across a porous matrix or medium with the objective to separate the charged molecules."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_2100249 a rdfs:Class ;
  rdfs:label "chem16 venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0001059 a rdfs:Class ;
  rdfs:label "ELISA microplate reader" ;
  rdfs:comment "A microplate reader that is used for enzyme-linked immunosorbent assays (ELISA)."@en ;
  rdfs:subClassOf obo:OBI_0001058 .

obo:OBI_2100200 a rdfs:Class ;
  rdfs:label "random venous blood tobramycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of tobramycin in venous blood as part of a random order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100045 .

obo:OBI_0200128 a rdfs:Class ;
  rdfs:label "directed network graph construction"@en ;
  rdfs:comment "A network graph construction in which an input data set describing objects and directional relationships between objects is transformed into and output representation of these objects as nodes and the directional relationships as directed edges of a network graph."@en ;
  rdfs:subClassOf obo:OBI_0200126 .

obo:OBI_2100090 a rdfs:Class ;
  rdfs:label "basic metabolic panel venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood as part of a basic metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:OBI_0003066 a rdfs:Class ;
  rdfs:label "easting coordinate measurement datum" ;
  rdfs:comment "A one dimensional Cartesian spatial coordinate datum that is the eastward component of a distance from a point on a map projection."@en ;
  rdfs:subClassOf obo:IAO_0000401 .

obo:OBI_0001104 a rdfs:Class ;
  rdfs:label "analytical balance" ;
  rdfs:comment "A balance with weighing pan(s) inside a transparent enclosure that is used to measure mass to a very high degree of precision and accuracy."@en ;
  rdfs:subClassOf obo:OBI_0001135 .

obo:OBI_2100134 a rdfs:Class ;
  rdfs:label "venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:UBERON_0001913 a rdfs:Class ;
  rdfs:label "milk" ;
  rdfs:comment "An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0003180 a rdfs:Class ;
  rdfs:label "direct bilirubin concentration assay" ;
  rdfs:comment "A bilirubin IXalpha assay that measures the concentration of direct bilirubin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100018 .

obo:COB_0000116 a rdfs:Class ;
  rdfs:label "obsolete cellular membrane" .

obo:OBI_0003501 a rdfs:Class ;
  rdfs:label "functional assessment of individual" ;
  rdfs:comment "A physical examination of an organism's ability to perform functional activities."@en ;
  rdfs:subClassOf obo:OBI_0002441 .

obo:OBI_0000594 a rdfs:Class ;
  rdfs:label "column adapter" ;
  rdfs:comment "An Adapter that enabled the connection of a column to additional devices."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0000549 a rdfs:Class ;
  rdfs:label "column cartridger" ;
  rdfs:comment "A chromatography device where the column cartridge is inserted into and stabilised."@en ;
  rdfs:subClassOf obo:OBI_0000485 .

obo:OBI_0002432 a rdfs:Class ;
  rdfs:label "history of sex with someone with a history of blood borne infection  exclusion criterion" ;
  rdfs:comment "An exclusion criterion defined  as whether an individual has a history of sex with someone who has been diagnosed or at risk for a blood borne infections disease in a specified time frame, which if met, makes the individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0003461 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from tumor challenge" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from tumor challenge."@en ;
  rdfs:subClassOf obo:OBI_0001183 , obo:OBI_0002073 .

obo:OBI_0002674 a rdfs:Class ;
  rdfs:label "case series design" ;
  rdfs:comment "A study design that samples only subjects who have experienced a particular event (outcome or exposure). Such a design, in contrast to a cohort study, does not permit calculation of absolute risk as non-case subjects are not included."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0000520 a rdfs:Class ;
  rdfs:label "clinical chemistry assay" ;
  rdfs:comment "An analyte assay which uses analytical methods to produce measurements and data on the concentration of chemical parameters (analytes) present in a specimen collected from an organism in order to determine a phenotype of that organism."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002049 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 4000" ;
  rdfs:comment "A DNA sequencer manufactured by Illumina corporation, with two flow cell and a throughput of more than 400 Gb per day."@en ;
  rdfs:subClassOf obo:OBI_0003683 .

obo:CHEBI_37445 a rdfs:Class ;
  rdfs:label "folic acids" ;
  rdfs:comment "A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more <small>L</small>-glutamic acid units." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000904 a rdfs:Class ;
  rdfs:label "reporter cell line analyte detection bioassay" ;
  rdfs:comment "An analyte assay in which a cell line whose growth is known to be affected by the presence of a specific type of material (the anlyte) is cultured in the presence of an input material (the evaluant) in order to detect presence of the analyte in the evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003587 .

obo:OBI_0003092 a rdfs:Class ;
  rdfs:label "Cell DIVE multiplexed imaging assay" ;
  rdfs:comment "A multiplexed fluorescent antibody imaging assay that involves an iterative staining, imaging and dye inactivation workflow for over 60 biomarkers on a single fixed tissue section."@en ;
  rdfs:subClassOf obo:OBI_0003091 .

obo:OBI_0003598 a rdfs:Class ;
  rdfs:label "single cell B cell receptor repertoire sequencing assay" ;
  rdfs:comment "A B cell receptor repertoire sequencing assay that determines the sequence of DNA or RNA molecules that encode the repertoire of B cell receptors that can be traced to a single cell of origin."@en ;
  rdfs:subClassOf obo:OBI_0002991 .

obo:GO_0032627 a rdfs:Class ;
  rdfs:label "interleukin-23 production" ;
  rdfs:comment "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_1110206 a rdfs:Class ;
  rdfs:label "epitope specific TNF release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce TNF resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032640 , obo:OBI_0001351 .

obo:OBI_0001744 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-1 alpha production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001388 .

obo:OBI_0003246 a rdfs:Class ;
  rdfs:label "feces microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a feces microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003245 .

obo:OBI_0000499 a rdfs:Class ;
  rdfs:label "NMR console" ;
  rdfs:comment "A component of an NMR instrument that controls the activities of the other components."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001560 a rdfs:Class ;
  rdfs:label "obsolete cell lysate MHC binding constant determination assay" ;
  rdfs:comment "An assay that measures the affinity of a ligand to a MHC in a cell lysate preparation and that quantifies the affinity with a binding constant."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:GO_0005216 a rdfs:Class ;
  rdfs:label "monoatomic ion channel activity" ;
  rdfs:comment "Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_2100143 a rdfs:Class ;
  rdfs:label "cooximitery arterial blood methemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of methemoglobin in arterial blood as part of a cooximitery order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100040 .

obo:GO_0007565 a rdfs:Class ;
  rdfs:label "female pregnancy" ;
  rdfs:comment "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." ;
  rdfs:subClassOf obo:GO_0022414 .

obo:OBI_0002998 a rdfs:Class ;
  rdfs:label "arthropod collection process with automated identification" ;
  rdfs:comment "An arthropod specimen collection process that involves a device that produces data specifying the types of arthropod collected."@en ;
  rdfs:subClassOf obo:OBI_0002913 .

obo:OBI_0200037 a rdfs:Class ;
  rdfs:label "pareto scaling"@en ;
  rdfs:comment "A pareto scaling is a data transformation that divides all measurements of a variable by the square root of the standard deviation of that variable."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0001202 a rdfs:Class ;
  rdfs:label "innate behavior design" ;
  rdfs:comment "A study design in which the innate behavior of the organism is examined, e.g. path finding in bees."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0400013 a rdfs:Class ;
  rdfs:label "band pass filter" ;
  rdfs:comment "A band pass filter is an optical filter that passes wavelengths of light within a certain range and rejects (attenuates) frequencies outside that range. The passed wavelengths are indicated in the specifications of the filter and its name. A 480/20 band-pass filter pass light with at wavelengths of 460 to 500 nm and attenuates all others."@en ;
  rdfs:subClassOf obo:OBI_0400079 .

obo:OBI_0003122 a rdfs:Class ;
  rdfs:label "3D cell structure determination assay" ;
  rdfs:comment "A 3D structure determination assay that determines the 3-dimensional configuration of a cell."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0600045 .

obo:GO_0045087 a rdfs:Class ;
  rdfs:label "innate immune response" ;
  rdfs:comment "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." ;
  rdfs:subClassOf obo:GO_0006955 .

obo:OBI_0000922 a rdfs:Class ;
  rdfs:label "frozen specimen" ;
  rdfs:comment "A specimen that has been frozen in order to store it."@en ;
  rdfs:subClassOf obo:OBI_0001472 , obo:OBI_0100051 .

obo:OBI_0002098 a rdfs:Class ;
  rdfs:label "assay measuring the on rate [kon] of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A T cell epitope binding constant determination assay that measures the on rate."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002059 .

obo:OBI_0003286 a rdfs:Class ;
  rdfs:label "urine microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a urine specimen."@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_0003498 .

obo:OBI_0002824 a rdfs:Class ;
  rdfs:label "surface wipe" ;
  rdfs:comment "A sample collection device consisting of a thin, less absorbent sheet, used to collect material from surfaces."@en ;
  rdfs:subClassOf obo:OBI_0002814 .

obo:OBI_0003805 a rdfs:Class ;
  rdfs:label "opacity determination assay" ;
  rdfs:comment "An assay that measures the opacity of the evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000560 a rdfs:Class ;
  rdfs:label "ion exchange column" ;
  rdfs:comment "An ion exchange column is a chromatography column that is used in ion exchange chromatography and anion or cation exchange resins to enable separation."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_1110196 a rdfs:Class ;
  rdfs:label "epitope specific IL-1b release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-1b resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032611 , obo:OBI_0001193 .

obo:OBI_0001389 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-6 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-6 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001451 .

obo:OBI_0000011 a rdfs:Class ;
  rdfs:label "obsolete planned process" ;
  rdfs:comment "A process that realizes a plan which is the concretization of a plan specification."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100392 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid mesothelial cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of mesothelial cells in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003232 .

obo:OBI_0001931 a rdfs:Class ;
  rdfs:label "scalar value specification" ;
  rdfs:comment "A value specification that consists of two parts: a numeral and a unit label"@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_0302867 a rdfs:Class ;
  rdfs:label "predicted data item"@en ;
  rdfs:comment "A data item that was generated on the basis of a calculation or logical reasoning"@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0001422 a rdfs:Class ;
  rdfs:label "organism part comparison design" ;
  rdfs:comment "A study design that compares tissues, regions, organs within or between organisms"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003558 a rdfs:Class ;
  rdfs:label "conjunctival administration" ;
  rdfs:comment "An administration of a substance to the conjunctiva of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:PATO_0001337 a rdfs:Class ;
  rdfs:label "yeast mating type" ;
  rdfs:comment "A yeast mating type." ;
  rdfs:subClassOf obo:PATO_0001895 .

obo:OBI_0002918 a rdfs:Class ;
  rdfs:label "knockdown arthropod specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process that involves exposing arthropods to pesticide, then collecting them once they become dead or immobilized."@en ;
  rdfs:subClassOf obo:OBI_0002919 .

obo:OBI_0002198 a rdfs:Class ;
  rdfs:label "molecular analysis facility organization"@en ;
  rdfs:comment "An organization that provides molecular analysis service."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0200196 a rdfs:Class ;
  rdfs:label "correlation study objective" ;
  rdfs:comment "A data transformation objective in which correlation is obtained (often measured as a correlation coefficient, ρ) which indicates the strength and direction of a relationship between two random variables."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0001697 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific treatment of disease" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that detects a decrease in disease."@en ;
  rdfs:subClassOf obo:OBI_0001190 , obo:OBI_0001698 .

obo:CHEBI_17855 a rdfs:Class ;
  rdfs:label "triglyceride" ;
  rdfs:comment "Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0400095 a rdfs:Class ;
  rdfs:label "short pass filter" ;
  rdfs:comment "A short pass filter is an optical filter that passes low wavelengths of light but attenuates (or reduces) wavelengths higher than the cutoff frequency. A short pass filter with a cutoff of 500 nm would pass all wavelengths less than 500 nm."@en ;
  rdfs:subClassOf obo:OBI_0400079 .

obo:OBI_0001985 a rdfs:Class ;
  rdfs:label "microarray assay" ;
  rdfs:comment "An analyte assay where binding of the analyte to immobilized matrix is measured."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001165 a rdfs:Class ;
  rdfs:label "age since coitus measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since coitus, the process of copulation that occurs during the process of sexual reproduction."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0003400 a rdfs:Class ;
  rdfs:label "Affymetrix Clariom S Assay, Mouse" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, to obtain a gene-level view of the mouse transcriptome. The assay design covers >20,000 well-annotated genes, providing researchers with the ability to perform gene-level expression profiling studies, to identify expression biomarkers, and to quickly assess changes in key genes and pathways."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0001751 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interferon-beta production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interferon-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001390 .

obo:OBI_0003718 a rdfs:Class ;
  rdfs:label "pulse rate assay" ;
  rdfs:comment "A vital sign assay that measures the heart beat rate of an organism."@en ;
  rdfs:subClassOf obo:OBI_0003715 .

obo:OBI_0001749 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interferon-beta production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interferon-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001390 .

obo:OBI_0002609 a rdfs:Class ;
  rdfs:label "rectal swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of a rectum."@en ;
  rdfs:subClassOf obo:OBI_0002599 , obo:OBI_0003483 .

obo:OBI_0000426 a rdfs:Class ;
  rdfs:label "injection"@en ;
  rdfs:comment "injection is process which aims at introducing a compound or a mixture into a material entity (either biological entity or instrument) by relying on devices such as syringe or injector connection, attached or forced into a vascular system (veins of an organism or tubes of a machine) or in a tissue."@en ;
  rdfs:subClassOf obo:OBI_0000274 .

obo:OBI_0002412 a rdfs:Class ;
  rdfs:label "premenopausal status" ;
  rdfs:comment "A menopausal status indicating that less than 6 months has passed since the last menstrual period and there has not been prior bilateral oophorectomy and not on estrogen replacement."@en ;
  rdfs:subClassOf obo:OBI_0002410 .

obo:OBI_0003010 a rdfs:Class ;
  rdfs:label "fibrinogen assay" ;
  rdfs:comment "An assay that measures fibrinogen"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0200099 a rdfs:Class ;
  rdfs:label "discriminant function analysis"@en ;
  rdfs:comment "Discriminant function analysis is a form of discriminant analysis used to determine which variables discriminate between two or more naturally occurring groups. Analysis is used to determine which variable(s) are the best predictors of a particular outcome."@en ;
  rdfs:subClassOf obo:OBI_0000663 , obo:OBI_0200106 , obo:OBI_0200175 .

obo:OBI_0002478 a rdfs:Class ;
  rdfs:label "reference genome-transcriptome alignment algorithm"@en ;
  rdfs:comment "An algorithm that attempts to align a nucleic acid sequence to a reference genome and transcriptome."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_2100058 a rdfs:Class ;
  rdfs:label "automated differential venous blood eosinophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of eosinophils in venous blood as part of a automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003023 , obo:OBI_0003040 .

obo:OBI_0003280 a rdfs:Class ;
  rdfs:label "virus in pleural fluid datum" ;
  rdfs:comment "A pleural fluid microbiology datum that is about a virus."@en ;
  rdfs:subClassOf obo:OBI_0003258 .

obo:OBI_0003483 a rdfs:Class ;
  rdfs:label "digestive tract specimen" ;
  rdfs:comment "A specimen that is derived from part of a digestive tract."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0003587 a rdfs:Class ;
  rdfs:label "cell culture assay" ;
  rdfs:comment "An assay that has cell culture as an input."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002510 a rdfs:Class ;
  rdfs:label "synovial fluid specimen" ;
  rdfs:comment "A specimen that is derived from synovial fluid."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_2100238 a rdfs:Class ;
  rdfs:label "chem16 venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0001186 a rdfs:Class ;
  rdfs:label "epitope protection from infectious challenge experiment based on pathogen burden" ;
  rdfs:comment "An epitope protection from infectious challenge experiment in which the readout is a reduction in the presence of pathogens in the host compared to controls."@en ;
  rdfs:subClassOf obo:OBI_0001179 .

obo:GO_0003015 a rdfs:Class ;
  rdfs:label "heart process" ;
  rdfs:comment "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0500023 a rdfs:Class ;
  rdfs:label "compliance rule"@en ;
  rdfs:comment "a compliance rule is a rule which ensures a compliance process occurs"@en ;
  rdfs:subClassOf obo:IAO_0000055 .

obo:OBI_0001889 a rdfs:Class ;
  rdfs:label "specimen provider principal investigator"@en ;
  rdfs:comment "A person who is a principal investigator and provides the specimen"@en ;
  rdfs:subClassOf obo:NCBITaxon_9606 .

obo:OBI_0000646 a rdf:Property ;
  rdfs:label "provisions" ;
  rdfs:comment "A relation between an organisation or person and a material entity, where the organization or person provides or supplies the material entity for others to use"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_2100083 a rdfs:Class ;
  rdfs:label "liver evaluation venous blood human aspartate aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a liver evaluation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100019 .

obo:UBERON_0001103 a rdfs:Class ;
  rdfs:label "diaphragm" ;
  rdfs:comment "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0000826 a rdfs:Class ;
  rdfs:label "treatment portion of study execution" ;
  rdfs:comment "A planned process, part of a study design execution, during which the treatment of subjects is ongoing"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000795 a rdfs:Class ;
  rdfs:label "glucometer" ;
  rdfs:comment "A measurement device with the function to measure and record the level/amount of glucose in a blood sample"@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0002535 a rdfs:Class ;
  rdfs:label "esophagus muscularis mucosa specimen" ;
  rdfs:comment "A specimen that is derived from esophagus muscularis mucosa."@en ;
  rdfs:subClassOf obo:OBI_0002532 , obo:OBI_0003483 .

obo:OBI_2100115 a rdfs:Class ;
  rdfs:label "lipid panel venous blood low density lipoprotein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of low density lipoprotein in venous blood as part of a lipid panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100032 .

obo:OBI_0001354 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-17 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001295 , obo:OBI_0600031 .

obo:OBI_0001303 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects granulocyte macrophage colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001233 .

obo:OBI_0001672 a rdfs:Class ;
  rdfs:label "gene knock-down assay" ;
  rdfs:comment "An assay which transiently disrupts gene transcripts by expressing antisense RNA constructs or delivering RNA interfering molecules in cells."@en ;
  rdfs:subClassOf obo:OBI_0003587 .

obo:OBI_0001974 a rdfs:Class ;
  rdfs:label "Ion 314 Chip v2" ;
  rdfs:comment "An ion semiconductor chip manufactured by Life Technologies which detects polymerase-driven base incorporation to translate into digital form. The 314 chip is compatible with the Ion Torrent PGM and has a run time of: 2.3 hours for 200 bp reads with an output of 30-50 Mb, 3.7 hours for 400 bp reads with an output of 60-100 Mb."@en ;
  rdfs:subClassOf obo:OBI_0001973 .

obo:GO_0004111 a rdfs:Class ;
  rdfs:label "creatine kinase activity" ;
  rdfs:comment "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0002788 a rdfs:Class ;
  rdfs:label "non-medical mask" ;
  rdfs:comment "A face mask not manufactured according to medical equipment standards."@en ;
  rdfs:subClassOf obo:OBI_0002787 .

obo:GO_0097281 a rdfs:Class ;
  rdfs:label "immune complex formation" ;
  rdfs:comment "The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus." ;
  rdfs:subClassOf obo:GO_0016064 .

obo:OBI_0001046 a rdfs:Class ;
  rdfs:label "bioreactor" ;
  rdfs:comment "A device or system that supports a biologically active environment."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_2100379 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0003893 a rdfs:Class ;
  rdfs:label "NIC RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using nicotinic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001556 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring direct binding of a cell-lysate-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that detects direct binding of a cell-lysate-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001579 .

obo:OBI_0003504 a rdfs:Class ;
  rdfs:label "forced cough assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to cough forcefully."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:IAO_0000033 a rdfs:Class ;
  rdfs:label "directive information entity"@en ;
  rdfs:comment "An information content entity whose concretizations indicate to their bearer how to realize them in a process."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:PATO_0001585 a rdfs:Class ;
  rdfs:label "conductivity" ;
  rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's disposition to transmit of an entity through a medium." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_2100006 a rdfs:Class ;
  rdfs:label "neutrophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of neutrophils"@en ;
  rdfs:subClassOf obo:OBI_0003022 .

obo:OBI_2100018 a rdfs:Class ;
  rdfs:label "bilirubin IXalpha assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin IXalpha"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000911 a rdfs:Class ;
  rdfs:label "real time reverse-transcription polymerase chain reaction assay" ;
  rdfs:comment "An assay that uses a reverse transcription step (an RNA strand is reverse transcribed into its DNA complement using the enzyme reverse transcriptase) before a PCR assay."@en ;
  rdfs:subClassOf obo:OBI_0002692 .

obo:OBI_0001614 a rdfs:Class ;
  rdfs:label "GenBank ID"@en ;
  rdfs:comment "A CRID symbol uniquely indentifies the submitted GeneBank sequence record."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:GO_0006006 a rdfs:Class ;
  rdfs:label "glucose metabolic process" ;
  rdfs:comment "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001192 a rdfs:Class ;
  rdfs:label "epitope specific immune intervention" ;
  rdfs:comment "An administration in vivo to either actively or passively immunize an organism in order to induce a response against a specific immune epitope"@en ;
  rdfs:subClassOf obo:OBI_0001174 .

obo:OBI_0002431 a rdfs:Class ;
  rdfs:label "intravenous drug use exclusion criterion" ;
  rdfs:comment "An exclusion criterion defined as when an individual has a history of intravenous drug abuse for a specific timeframe, which if met, makes the individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0000340 a rdfs:Class ;
  rdfs:label "obsolete_documenting" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001264 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects transforming growth factor-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_1110095 a rdfs:Class ;
  rdfs:label "blood specimen collection"@en ;
  rdfs:comment "A specimen collection in which blood is collected from an organism."@en ;
  rdfs:subClassOf obo:OBI_0600005 .

obo:IAO_0000306 a rdfs:Class ;
  rdfs:label "table"@en ;
  rdfs:comment "A textual entity that contains a two-dimensional arrangement of texts repeated at regular intervals across a spatial range, such that the spatial relationships among the constituent texts expresses propositions"@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:OBI_0001116 a rdfs:Class ;
  rdfs:label "vacuum manifold" ;
  rdfs:comment "A device that is used for the vacuum-driven processing of multiwell strips or plates, or spin columns. IS THIS AN INSTRUMENT? IS THE DEFINTION CORRECT - TO DISTRIBUTE PRESSURE EVENLY."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001383 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific IP-10 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects IP-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001308 .

obo:OBI_0200032 a rdfs:Class ;
  rdfs:label "K-fold cross validation method"@en ;
  rdfs:comment "K-fold cross-validation randomly partitions the original sample into K subsamples. Of the K subsamples, a single subsample is retained as the validation data for testing the model, and the remaining K - 1 subsamples are used as training data. The cross-validation process is then repeated K times (the folds), with each of the K subsamples used exactly once as the validation data. The K results from the folds then can be averaged (or otherwise combined) to produce a single estimation. The advantage of this method over repeated random sub-sampling is that all observations are used for both training and validation, and each observation is used for validation exactly once. 10-fold cross-validation is commonly used"@en ;
  rdfs:subClassOf obo:OBI_0000792 .

obo:OBI_0002662 a rdfs:Class ;
  rdfs:label "bone marrow biopsy" ;
  rdfs:comment "A biopsy where a small amount of bone and a small amount of fluid and bone marrow are collected."@en ;
  rdfs:subClassOf obo:OBI_0002650 .

obo:OBI_0600051 a rdfs:Class ;
  rdfs:label "gradient separation"@en ;
  rdfs:comment "a protocol application that uses different concentrations of materials in a defined order to create a gradient to facilitate the separation of an input material into its components with specific qualities"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0400076 a rdfs:Class ;
  rdfs:label "multi-well plate"@en ;
  rdfs:comment "A particle deliver vessel. A multi-well plate is a vessel that can deliver multiple samples to a flow cytometer in a specified order. It must be used with a plate loader."@en ;
  rdfs:subClassOf obo:OBI_0400081 .

obo:OBI_0000925 a rdfs:Class ;
  rdfs:label "infectious agent"@en ;
  rdfs:comment "is a material entity bearing the disposition to infect an organism"@en ;
  rdfs:subClassOf obo:COB_0000022 .

obo:IAO_0000401 a rdfs:Class ;
  rdfs:label "one dimensional cartesian spatial coordinate datum"@en ;
  rdfs:comment "A cartesion spatial coordinate datum that  uses one value to specify a position along a one dimensional spatial region"@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002982 a rdfs:Class ;
  rdfs:label "reference gene sequence stop site" ;
  rdfs:comment "The position of the last nucelotide in a reference sequence (sequence being used for comparison)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001283 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-15 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-15 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001292 .

obo:OBI_2100240 a rdfs:Class ;
  rdfs:label "chem16 venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_2100176 a rdfs:Class ;
  rdfs:label "non-vented blood gas arterial blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a non-vented blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0000181 a rdfs:Class ;
  rdfs:label "population"@en ;
  rdfs:comment "a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003788 a rdfs:Class ;
  rdfs:label "cellular indexing of transcriptomes and epitopes by sequencing" ;
  rdfs:comment "An assay performed on single cells that simultaneously measures transcript expression via single-cell RNA sequencing and profiles surface proteins via sequencing of DNA-barcodes attached to antibodies recognizing particular surface proteins from individual cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000517 a rdfs:Class ;
  rdfs:label "NMR magnet" ;
  rdfs:comment "A magnet which induces a certain frequency (MHz) and which has a certain bore diameter.n  alt The NMR signal is a natural physical property of the certain atomic nuclei but it can only be detected with an external magnetic field. A magnet is a fundamental part of an NMR instrument which induces an electromagnetic force field (RF pulse) and by this excites and aligns the spins of the electrons of the NMR acquisition nucleus. It is usually a big (superconducting) electromagnet which is cooled by liquid helium and can be adjusted to a frequency between 200 and 950 MHz. The magnetic field strength is measured in Tesla or Gauss."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:UBERON_0000007 a rdfs:Class ;
  rdfs:label "pituitary gland" ;
  rdfs:comment "The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN]." ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:OBI_0002604 a rdfs:Class ;
  rdfs:label "breast swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of a breast."@en ;
  rdfs:subClassOf obo:OBI_0002523 , obo:OBI_0002599 .

obo:OBI_0600018 a rdfs:Class ;
  rdfs:label "material portioning"@en ;
  rdfs:comment "a material processing in which the input substance is partitioned into a number of portions that are similar in composition."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0000201 a rdfs:Class ;
  rdfs:label "radioactivity detection" ;
  rdfs:comment "An assay that measures the amount of radiation in the radioactive spectrum (alpha, beta or gamma rays) emitted from an input material."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001743 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-1 beta production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-1 beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001449 .

obo:OBI_0000390 a rdfs:Class ;
  rdfs:label "thermostatic circulator" ;
  rdfs:comment "A thermostatic circulator is a device which cools or heats a circulating liquid. It has the function to contain control the contained environment and transfer energy from or to the circulating liquid"@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0001567 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring binding off rate [koff] to determine direct binding of a cell-lysate-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures binding off rate [koff] to detect direct binding of a cell-lysate-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001993 .

obo:OBI_0001427 a rdfs:Class ;
  rdfs:label "transcription profiling by tiling array design" ;
  rdfs:comment "A study design in which gene expression on a genome-wide basis is evaluated, without bias toward coding or noncoding regions, using tiling arrays containing oligonucleotides that are either overlapping or spaced at regular intervals."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:CL_0000540 a rdfs:Class ;
  rdfs:label "neuron" ;
  rdfs:comment "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." ;
  rdfs:subClassOf obo:CL_0000404 , obo:CL_0002319 .

obo:OBI_2100148 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0000596 a rdfs:Class ;
  rdfs:label "Bruker NMR instrument" ;
  rdfs:comment "An NMR instrument that is manufactured by Bruker."@en ;
  rdfs:subClassOf obo:OBI_0000566 .

obo:SO_0000148 a rdfs:Class ;
  rdfs:label "supercontig" ;
  rdfs:comment "One or more contigs that have been ordered and oriented using end-read information. Contains gaps that are filled with N's." ;
  rdfs:subClassOf obo:SO_0000353 .

obo:OBI_0000837 a rdfs:Class ;
  rdfs:label "oral ingestion of pill" ;
  rdfs:comment "An adding a material entity to target with the entity is a pill and the target is the mouth"@en ;
  rdfs:subClassOf obo:OBI_0000952 .

obo:OBI_0200088 a rdfs:Class ;
  rdfs:label "Kaplan Meier"@en ;
  rdfs:comment "a nonparametric (actuarial) data transformation technique for estimating time-related events. It is a univariate analysis that estimates the probability of the proportion of subjects in remission at a particular time, starting from the initiation of active date (time zero), and takes into account those lost to follow-up or not yet in remission at end of study (censored)"@en ;
  rdfs:subClassOf obo:OBI_0200194 .

obo:OBI_0002171 a rdfs:Class ;
  rdfs:label "dot blot assay" ;
  rdfs:comment "An analyte assay that detects molecules in a mixture dotted on a membrane using DNA probes or antibodies."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000953 a rdfs:Class ;
  rdfs:label "processed specimen" ;
  rdfs:comment "A specimen that has been intentionally physically modified."@en ;
  rdfs:subClassOf obo:COB_0000026 , obo:OBI_0100051 .

obo:OBI_0001160 a rdfs:Class ;
  rdfs:label "assay validation objective"@en ;
  rdfs:comment "an objective specification to check the accuracy or the quality of the results of an assay by comparison with independent results"@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0002644 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on tumor burden" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using tumor burden."@en ;
  rdfs:subClassOf obo:OBI_0002052 , obo:OBI_0003477 .

obo:OBI_0001487 a rdfs:Class ;
  rdfs:label "B cell epitope specific immune intervention" ;
  rdfs:comment "An epitope specific immune intervention in which the induced response targets a B cell epitope"@en ;
  rdfs:subClassOf obo:OBI_0001192 .

obo:OBI_0003177 a rdfs:Class ;
  rdfs:label "total thyroxine concentration assay" ;
  rdfs:comment "A thyroxine assay that measures the concentration of total thyroxine in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100035 .

obo:OBI_2100191 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:PATO_0001710 a rdfs:Class ;
  rdfs:label "3-D extent" ;
  rdfs:comment "A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions." ;
  rdfs:subClassOf obo:PATO_0000117 .

obo:GO_0032611 a rdfs:Class ;
  rdfs:label "interleukin-1 beta production" ;
  rdfs:comment "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032612 .

obo:UBERON_0001874 a rdfs:Class ;
  rdfs:label "putamen" ;
  rdfs:comment "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001647 a rdfs:Class ;
  rdfs:label "NMR assay determining the 3D structure of a B cell epitope:antibody complex" ;
  rdfs:comment "A nuclear magnetic resonance 3D molecular structure determination assay that characterizes the 3-dimensional structure of a B cell epitope:antibody complex."@en ;
  rdfs:subClassOf obo:OBI_0000182 , obo:OBI_0001721 .

obo:OBI_0003819 a rdfs:Class ;
  rdfs:label "path length assay" ;
  rdfs:comment "An assay that measures the distance traveled in a defined period of time."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002611 a rdfs:Class ;
  rdfs:label "vagina swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of a vagina."@en ;
  rdfs:subClassOf obo:OBI_0002554 , obo:OBI_0002599 .

obo:OBI_0200163 a rdfs:Class ;
  rdfs:label "false discovery rate correction method"@en ;
  rdfs:comment "The false discovery rate is a  data transformation used in multiple hypothesis testing to correct for multiple comparisons. It controls the expected proportion of incorrectly rejected null hypotheses (type I errors) in a list of rejected hypotheses. It is a less conservative comparison procedure with greater power than familywise error rate (FWER) control, at a cost of increasing the likelihood of obtaining type I errors. ."@en ;
  rdfs:subClassOf obo:OBI_0200089 .

obo:OBI_0001805 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-7 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-7 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001587 .

obo:OBI_0001272 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects tumor necrosis factor superfamily cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001400 , obo:OBI_0600031 .

obo:OBI_0001840 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-17A production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-17A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001291 , obo:OBI_0001773 .

obo:OBI_0002579 a rdfs:Class ;
  rdfs:label "adapter-trimmed sequence data" ;
  rdfs:comment "The results of a data transformation of sequence data in which reference subsequences corresponding to ligated library adapters are removed."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0400043 a rdfs:Class ;
  rdfs:label "flow cell" ;
  rdfs:comment "Aparatus in the fluidic subsystem where the sheath and sample meet. Can be one of several types; jet-in-air, quartz cuvette, or a hybrid of the two. The sample flows through the center of a fluid column of sheath fluid in the flow cell."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0002676 a rdfs:Class ;
  rdfs:label "in vivo assay measuring a T cell epitope specific response after adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that is performed after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001484 .

obo:OBI_0003624 a rdfs:Class ;
  rdfs:label "antibody purification of pig MHC class I protein complex" ;
  rdfs:comment "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003616 , obo:OBI_0003635 .

obo:OBI_0003162 a rdfs:Class ;
  rdfs:label "metamyelocyte percentage assay" ;
  rdfs:comment "A metamyelocyte assay that measures the percentage of metamyelocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003017 .

obo:OBI_0002149 a rdfs:Class ;
  rdfs:label "core HBV antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to hepatitis B virus (HBV) core antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0002150 a rdfs:Class ;
  rdfs:label "core HBV IgM antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detectimmunoglobulin M (IgM) antibodies that bind to hepatitis B virus (HBV) core antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0003843 a rdfs:Class ;
  rdfs:label "tissue mass percent of body mass assay" ;
  rdfs:comment "A mass measurement assay with evaluant tissue expressed as a percentage of the body weight of the organism from which the specimen was derived."@en ;
  rdfs:subClassOf obo:OBI_0000445 .

obo:OBI_0000896 a rdfs:Class ;
  rdfs:label "secondary structure of RNA molecule" ;
  rdfs:comment ""@en ;
  rdfs:subClassOf obo:OBI_0000885 .

obo:OBI_0001571 a rdfs:Class ;
  rdfs:label "equilibrium dissociation constant (KD) approximated by IC50" ;
  rdfs:comment "A measurement of an IC50 value under specific assay conditions approximates KD, namely the binding reaction is at an equilibrium, there is a single population of sites on the receptor that competitor and ligand are binding to, and the concentration of the receptor must be much less than the KD for the competitor and the ligand.  In this case, according to Cheng and Prussoff, KD = IC50 / (1 + Lstot / KDs), in which Lstot is the total concentration of the labeled competitor and KDs is the KD value of that competitor."@en ;
  rdfs:subClassOf obo:OBI_0001536 , obo:OBI_0003144 .

obo:OBI_0002959 a rdfs:Class ;
  rdfs:label "tandem mass tag mass spectrometry assay" ;
  rdfs:comment "A type of tandem mass spectrometry where isotopomer labels are employed for accurate quantification and identification of specific proteins."@en ;
  rdfs:subClassOf obo:OBI_0003540 .

obo:PATO_0001193 a rdfs:Class ;
  rdfs:label "lateral to" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the side relative to another entity." ;
  rdfs:subClassOf obo:PATO_0000140 .

obo:OBI_0002031 a rdfs:Class ;
  rdfs:label "genotyping by SNP array assay" ;
  rdfs:comment "A genotyping by array assay that uses SNP array technology."@en ;
  rdfs:subClassOf obo:OBI_0001274 .

obo:OBI_2100159 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:GO_0071606 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 4 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:CHEBI_30660 a rdfs:Class ;
  rdfs:label "thyroxine" ;
  rdfs:comment "An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001452 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific tumor necrosis factor alpha production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects tumor necrosis factor alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001416 , obo:OBI_0003488 .

obo:OBI_2100180 a rdfs:Class ;
  rdfs:label "arterial blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0302897 a rdfs:Class ;
  rdfs:label "asphyxiation"@en ;
  rdfs:comment "asphyxiation is a process by which oxygen supplies are restricted (by mechanical, e.g obstructing airways or chemical means, e.g. increasing CO2 partial pressure) resulting in termination of life in oxygen reliant organisms."@en ;
  rdfs:subClassOf obo:OBI_0000919 .

obo:OBI_0000885 a rdfs:Class ;
  rdfs:label "secondary structure of sequence macromolecule" ;
  rdfs:comment """A quality inhering in a molecule that refers to general three-dimensional form of local segments of biopolymers such as proteins and nucleic acids (DNA/RNA). It does not, however, describe specific atomic positions in three-dimensional space, which are considered to be tertiary structure.
Secondary structure was introduced by Kaj Ulrik Linderstrøm-Lang in the 1952 Lane medical lectures at Stanford."""@en ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBI_0001942 a rdfs:Class ;
  rdfs:label "grant agency"@en ;
  rdfs:comment "An organization that provides funding support for projects such as investigations."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:UBERON_0001968 a rdfs:Class ;
  rdfs:label "semen" ;
  rdfs:comment "Organism substance that is composed of sperm cells suspended in seminal fluid." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OBI_0003724 a rdfs:Class ;
  rdfs:label "sperm count assay" ;
  rdfs:comment "A cytometry assay to count the number of mature sperm in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000700 a rdfs:Class ;
  rdfs:label "support vector machine" ;
  rdfs:comment "A support vector machine is a data transformation with a class prediction objective based on the construction of a separating hyperplane that maximizes the margin between two data sets of vectors in n-dimensional space."@en ;
  rdfs:subClassOf obo:OBI_0000663 .

obo:OBI_0003215 a rdfs:Class ;
  rdfs:label "progesterone concentration assay" ;
  rdfs:comment "A progesterone assay that measures the concentration of progesterone in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003214 .

obo:OBI_0001476 a rdfs:Class ;
  rdfs:label "phage display binding assay" ;
  rdfs:comment "A binding assay in which a collection of phages expressing a library of different peptides or protein fragnments is used to infect cells, followed by screening for cells that bind a protein of interest, and identifiying the sequence of infecting phages to determine a suitable binding partner."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:CL_0000236 a rdfs:Class ;
  rdfs:label "B cell" ;
  rdfs:comment "A lymphocyte of B lineage that is capable of B cell mediated immunity." ;
  rdfs:subClassOf obo:CL_0000542 .

obo:OBI_0001041 a rdfs:Class ;
  rdfs:label "stabilization function" ;
  rdfs:comment "A stabilization function is a function that holds or isolates an entity such as an instrument or specimen steadfast or at an unfluctuating level or quantity."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0003510 a rdfs:Class ;
  rdfs:label "finger taps assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to touch their finger-tip to thumb as many times as possible during a specified duration of time."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:CHEBI_17650 a rdfs:Class ;
  rdfs:label "cortisol" ;
  rdfs:comment "A 17α-hydroxy-C<small><sub>21</sub></small>-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the \"stress hormone\" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001455 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-5 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-5 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001230 , obo:OBI_0600031 .

obo:OBI_0003547 a rdfs:Class ;
  rdfs:label "liquid chromatography" ;
  rdfs:comment "A preparative chromatography in which material components are separated in a liquid solution."@en ;
  rdfs:subClassOf obo:OBI_0600046 .

obo:OBI_0001438 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects macrophage inflammatory protein-1 gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001456 .

obo:ENVO_00002257 a rdfs:Class ;
  rdfs:label "podzol" ;
  rdfs:comment "Podzols are soils with a typically ash-grey upper subsurface horizon, bleached by loss of organic matter and iron oxides, on top of a dark accumulation horizon with brown, reddish or black illuviated humus and/or reddish Fe compounds. Podzols occur in humid areas in the boreal and temperate zones and locally also in the tropics." ;
  rdfs:subClassOf obo:ENVO_00001998 .

obo:OBI_0001365 a rdfs:Class ;
  rdfs:label "cellular process design" ;
  rdfs:comment "A study design that aims to study the processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001015 a rdfs:Class ;
  rdfs:label "DMS structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay which determins nucleic acid secondary structure at a nucleotide resolution scale using DMS as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001762 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 21 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-C motif) ligand 21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001774 .

obo:OBI_2100166 a rdfs:Class ;
  rdfs:label "blood gas venous blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in venous blood as part of a blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0002203 a rdfs:Class ;
  rdfs:label "pTX" ;
  rdfs:comment "A cannot be assessed determination for pathologic primary tumor staging."@en ;
  rdfs:subClassOf obo:OBI_0002200 .

obo:OBI_0001182 a rdfs:Class ;
  rdfs:label "negative binding datum" ;
  rdfs:comment "A categorical binding datum that states that there is no significant disposition of two or more entities to form a complex."@en ;
  rdfs:subClassOf obo:OBI_0003141 .

obo:OBI_0302910 a rdfs:Class ;
  rdfs:label "prediction"@en ;
  rdfs:comment "a process by which an  event or an entity is described before it actually happens or is being discovered and identified."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001816 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-X-C motif) ligand 13 production by T cells" ;
  rdfs:comment "A process of chemokine (C-X-C motif) ligand 13 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0097391 , obo:OBI_0001193 .

obo:OBI_0100016 a rdfs:Class ;
  rdfs:label "blood plasma specimen" ;
  rdfs:comment "a material entity which corresponds to the liquid component of blood, in which the blood cells are suspended."@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0001134 a rdfs:Class ;
  rdfs:label "agarose gel electrophoresis system" ;
  rdfs:comment "A gel electrophoresis system that is used to separate DNA or RNA molecules by size, achieved by moving negatively charged nucleic acid molecules through an agarose matrix with an electric field."@en ;
  rdfs:subClassOf obo:OBI_0001121 .

obo:OBI_0003291 a rdfs:Class ;
  rdfs:label "in silico design" ;
  rdfs:comment "A study design that is executed primarily on a computer."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_2100385 a rdfs:Class ;
  rdfs:label "venous blood erythropoietin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of erythropoietin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0002971 a rdfs:Class ;
  rdfs:label "endotracheal tube specimen" ;
  rdfs:comment "A specimen that derives from a biofilm that forms on the inner surface of an endotracheal tube while the tube is in the trachea. The specimen is collected upon removal of the tube from the trachea."@en ;
  rdfs:subClassOf obo:OBI_0002783 .

obo:OBI_0400069 a rdfs:Class ;
  rdfs:label "Luminex 100" ;
  rdfs:comment "The Luminex 100 is a flow_cytometer_analyser manufactured by Luminex. It is a single laser system (575 nm) with avalanche photodiodes in red and infrared and a single PMT for fluorescence. The flow chamber is a square quartz cuvette."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0003365 a rdfs:Class ;
  rdfs:label "milk assay datum" ;
  rdfs:comment "A data entity that is the specified output of a milk assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002434 a rdfs:Class ;
  rdfs:label "HIV exclusion criterion" ;
  rdfs:comment "An exclusion criterion defined  as whether an individual has a history of repeatedly reactive screening assays for HIV-1 or HIV-2 antibody regardless of the results of supplemental assays, which if met, makes the individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0003297 a rdfs:Class ;
  rdfs:label "tyramide signal amplification sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that uses tyramide signal amplification (TSA) to assess distance of DNA regions to a targeted nuclear compartment or protein, typically on a scale of 100-1000 nm."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0002622 a rdfs:Class ;
  rdfs:label "in vitro transcription reconstitution assay" ;
  rdfs:comment "A reconstitution assay in which RNA synthesis is investigated using RNA polymerase II transcription systems replicated in vitro from their base components."@en ;
  rdfs:subClassOf obo:OBI_0002621 .

obo:PR_000008725 a rdfs:Class ;
  rdfs:label "haptoglobin" ;
  rdfs:comment "A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003782 a rdfs:Class ;
  rdfs:label "metabolomics by mass spectrometry assay" ;
  rdfs:comment "A mass spectrometry assay that identifies and measures metabolites."@en ;
  rdfs:subClassOf obo:OBI_0000366 .

obo:OBI_0400098 a rdfs:Class ;
  rdfs:label "SomaScope" ;
  rdfs:comment "The SomaScope is an instrument to quantify somatic cells in milk."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0002987 a rdfs:Class ;
  rdfs:label "positron emission tomography imaging assay" ;
  rdfs:comment "An imaging assay in which positron-emitting radionuclides are used to visualize functional processes of an input material entity."@en ;
  rdfs:subClassOf obo:OBI_0000185 .

obo:OBI_0002830 a rdfs:Class ;
  rdfs:label "catheter" ;
  rdfs:comment "A device which is a flexible tube inserted into a body and which enables transfer of fluids into or out of a body."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001314 a rdfs:Class ;
  rdfs:label "epitope specific T cell enhancement of B cell mediated immune response" ;
  rdfs:comment "A process of T cell enhancement of B cell mediated immune response resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0035399 .

obo:OBI_0002417 a rdfs:Class ;
  rdfs:label "exposure to asbestos history" ;
  rdfs:comment "An exposure to environmental and workplace carcinogens history where the carcinogen is asbestos."@en ;
  rdfs:subClassOf obo:OBI_0002415 .

obo:OBI_0002925 a rdfs:Class ;
  rdfs:label "BG-Sentinel trap" ;
  rdfs:comment "An arthropod trap that is manufactured by Biogents and is designed to attract arthropods through the use of a motorized fan to mimic convection currents produced by a human. The current also pulls arthropods into the trap, where a layer of gauze prevents the arthropods from escaping along with the air current."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0000909 a rdfs:Class ;
  rdfs:label "cloacal specimen" ;
  rdfs:comment "A specimen obtained by inserting a swab deeply into the vent of the cloaca of an organism and vigorously swabbing the wall. The swab should be deeply stained with fecal material and is then placed in transport medium."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001683 a rdfs:Class ;
  rdfs:label "chromosome organization assay by fluorescence in-situ hybridization" ;
  rdfs:comment "An in-situ hybridization assay that uses fluorescence to detect chromosomal integrity"@en ;
  rdfs:subClassOf obo:OBI_0001686 .

obo:OBI_0000448 a rdfs:Class ;
  rdfs:label "packed column" ;
  rdfs:comment "A packed column is a chromatography column where the particles of the solid stationary phase or the support coated with a liquid stationary phase may fill the whole inside volume of the tube."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0002086 a rdfs:Class ;
  rdfs:label "Tet-assisted bisulfite sequencing assay" ;
  rdfs:comment "A bisulfite sequencing assay that identifies genomic methylation patterns by using a bisulfite based protocol with the Tet enzyme to differentiate 5-hydroxylmethylcytosine (5hmC) from 5-methylcytosine (5mC) through a step-wise oxidative demethylation of 5mC, converting it to 5-carboxylcytosine (5caC) while keeping 5hmC protected."@en ;
  rdfs:subClassOf obo:OBI_0000748 .

obo:OBI_0003342 a rdfs:Class ;
  rdfs:label "post-Gd T1 weighted magnetic resonance image data set" ;
  rdfs:comment "A T1 weighted image data set where gadolidium contrast agent has been administered to the participant before image acquistion."@en ;
  rdfs:subClassOf obo:OBI_0003341 .

obo:OBI_2100220 a rdfs:Class ;
  rdfs:label "fasting venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood as part of a fasting order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0002777 a rdfs:Class ;
  rdfs:label "cytometry analysis by manual gating" ;
  rdfs:comment "A gating in which the output of a flow- or mass- cytometry experiment is separated into gates that were set by a human operator in order to quantify the frequency of different cell populations of interest."@en ;
  rdfs:subClassOf obo:OBI_0200077 .

obo:PATO_0001167 a rdfs:Class ;
  rdfs:label "damaged" ;
  rdfs:comment "A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired." ;
  rdfs:subClassOf obo:PATO_0001020 .

obo:OBI_0003512 a rdfs:Class ;
  rdfs:label "heel to shin assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to tap their heel to the midpoint of the contralateral shin a number of times."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0000711 a rdfs:Class ;
  rdfs:label "library preparation" ;
  rdfs:comment "is a process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_2100292 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood lactic acid assay" ;
  rdfs:comment "An assay that measures lactic acid in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100042 .

obo:OBI_0001147 a rdfs:Class ;
  rdfs:label "cell culture expansion"@en ;
  rdfs:comment "a process that results in the increase of cell numbers"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001507 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific treatment of disease" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that detects a decrease in disease."@en ;
  rdfs:subClassOf obo:OBI_0001190 , obo:OBI_0001484 .

obo:OBI_0000223 a rdfs:Class ;
  rdfs:label "obsolete_blinded medication role" ;
  rdfs:comment "Is a role which inheres in a material entity which is manufactured to be similar in appearance to a test material entity in e.g. a clinical trial to prevent participants from detecting which is the active and inactive substance"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002079 a rdfs:Class ;
  rdfs:label "specimens collected in one encounter"@en ;
  rdfs:comment "A collection of specimens that is collected from one source (e.g. one organism) during a time period which for the purpose of the study can be considered to be taken at the same sampling time."@en ;
  rdfs:subClassOf obo:OBI_0002076 .

obo:OBI_9999994 a rdfs:Class ;
  rdfs:label "chromium release assay" ;
  rdfs:comment "An in vitro cell killing assay in which radioactive chromium is absorbed by cells and released into supernatant when the cells die. The amount of radioactivity measured in the supernatant is a proxy for the number of cells that have died."@en ;
  rdfs:subClassOf obo:OBI_0000903 .

obo:UBERON_0000061 a rdfs:Class ;
  rdfs:label "anatomical structure" ;
  rdfs:comment "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_2100324 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood megakaryocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of megakaryocytes in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:OBI_0001123 a rdfs:Class ;
  rdfs:label "microdissection instrument" ;
  rdfs:comment "A device that is used for the dissection of tissues under magnification."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000553 a rdfs:Class ;
  rdfs:label "Bruker Capillary LC-NMR platform" ;
  rdfs:comment "Capillary LC-NMR is a hyphenated technique coupling capillary liquid chromatography and NMR, which increases sensitivity dramatically through the use of miniaturization of the chromatographic techniques and NMR detection volume. LC-NMR hyphenated systems separate a mixture into its pure components and couple the output to NMR for automatic sample analysis. The ever increasing need to measure lower sample amounts and lower level impurities demands the highest NMR sensitivity. Traditional LC-NMR systems with relatively large peak volumes are not optimized for such low levels of detection. Bruker BioSpin, together with Waters and Protasis has developed a Capillary LC-NMR system. The latest capillary LC attributes and highest capillary flow probe sensitivity combine with state of the art NMR systems technology. Greater mass sensitivity and faster spectral analysis with smaller sample volumes is possible. This system is ideal for analysis of metabolites and impurities associated with the drug development process."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:OBI_0200185 a rdfs:Class ;
  rdfs:label "scaling data transformation"@en ;
  rdfs:comment "A scaling data transformation is a data transformation that has objective scaling."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001171 a rdfs:Class ;
  rdfs:label "half life datum (t 1/2)" ;
  rdfs:comment "The time it takes for 50% of a class of stochastic processes to occur."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:PATO_0001347 a rdfs:Class ;
  rdfs:label "F mating type" ;
  rdfs:comment "A bacterial mating type indicating the presence of F plasmid in a bacterial cell." ;
  rdfs:subClassOf obo:PATO_0001335 .

obo:OBI_0001878 a rdfs:Class ;
  rdfs:label "establishing primary cell culture"@en ;
  rdfs:comment "an establishing cell culture process whereby cells explanted directly from an organismal source or specimen, and placed in culture for maintenance or propagation as a primary cell culture"@en ;
  rdfs:subClassOf obo:OBI_0600036 .

obo:OBI_0002025 a rdfs:Class ;
  rdfs:label "Human Exon 1.0 ST tilling array" ;
  rdfs:comment "A tiling microarray which is manufactured by the Affymetrix corporation. Built to analyze 3' DNA sequence copy number by comparative genomic hybridization for human DNA against 28,000 genes. It  can be used for gene expression and alternative splicing assay"@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_2100154 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood human alkaline phosphatase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100017 .

obo:OBI_2100125 a rdfs:Class ;
  rdfs:label "hemoglobin oxygen saturation arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a hemoglobin oxygen saturation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0003081 a rdfs:Class ;
  rdfs:label "extraction date" ;
  rdfs:comment "A time measurement datum that specifies when some material was extracted from an input material."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0002712 a rdfs:Class ;
  rdfs:label "WHO paper kit diagnostic assay" ;
  rdfs:comment "A direct insecticide resistance diagnostic assay uses WHO paper kit."@en ;
  rdfs:subClassOf obo:OBI_0002707 .

obo:IAO_0000064 a rdfs:Class ;
  rdfs:label "algorithm"@en ;
  rdfs:comment "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0002509 a rdfs:Class ;
  rdfs:label "sweat specimen" ;
  rdfs:comment "A specimen that is derived from sweat."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0001228 a rdfs:Class ;
  rdfs:label "in vivo assay measuring epitope specific helper T cell enhancement of a B cell mediated immune response" ;
  rdfs:comment "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance an antibody response."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001495 .

obo:OBI_0003133 a rdfs:Class ;
  rdfs:label "cas mediated mutagenesis" ;
  rdfs:comment "An endonuclease mediated mutagenesis in which guide RNAs and cas are used to introduce a mutation at a specific location in the genome."@en ;
  rdfs:subClassOf obo:OBI_0003132 .

obo:CL_0000057 a rdfs:Class ;
  rdfs:label "fibroblast" ;
  rdfs:comment "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0002597 a rdfs:Class ;
  rdfs:label "chromosome conformation capture sequencing assay" ;
  rdfs:comment "A chromosome conformation capture-on-chip assay quantitates the products with multiplexed high-throughput sequencing."@en ;
  rdfs:subClassOf obo:OBI_0002458 , obo:OBI_0600047 .

obo:OBI_0002633 a rdfs:Class ;
  rdfs:label "PacBio Sequel II" ;
  rdfs:comment "A DNA sequencer built upon single molecule real-time sequencing technology, optimized for generation of highly accurate (\"HiFi\") long reads, and which is manufactured by the Pacific Biosciences corporation."@en ;
  rdfs:subClassOf obo:OBI_0003923 .

obo:OBI_0001294 a rdfs:Class ;
  rdfs:label "wild type organism genotype information"@en ;
  rdfs:comment "a genotype information about an organism and includes information that there are no known modifications to the genetic background. Generally it is the genotype information of a representative individual from a class of organisms."@en ;
  rdfs:subClassOf obo:OBI_0001305 .

obo:OBI_0003149 a rdfs:Class ;
  rdfs:label "basophil percentage assay" ;
  rdfs:comment "A basophil assay that measures the percentage of basophils in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003021 .

obo:OBI_0003638 a rdfs:Class ;
  rdfs:label "antibody purification of human MHC class II protein complex" ;
  rdfs:comment "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class II protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003636 .

obo:GO_0032622 a rdfs:Class ;
  rdfs:label "interleukin-19 production" ;
  rdfs:comment "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:UBERON_0000310 a rdfs:Class ;
  rdfs:label "breast" ;
  rdfs:comment "The upper ventral region of the torso of an organism." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001433 a rdfs:Class ;
  rdfs:label "radio immuno assay measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "A radio immuno assay that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000910 , obo:OBI_0001414 .

obo:PR_000025475 a rdfs:Class ;
  rdfs:label "ribonuclease U2" ;
  rdfs:comment "A protein that is a translation product of the Ustilago sphaerogena RNU2 gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003654 a rdfs:Class ;
  rdfs:label "overnight fasting"@en ;
  rdfs:comment "A fasting with a duration of 8–12 hours, typically occurring overnight."@en ;
  rdfs:subClassOf obo:OBI_0003653 .

obo:OBI_0003257 a rdfs:Class ;
  rdfs:label "nasopharyngeal or oropharyngeal swab microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a nasopharyngeal or oropharyngeal swab microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 .

obo:OBI_0003629 a rdfs:Class ;
  rdfs:label "antibody purification of H2-Db protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Db protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003627 , obo:OBI_0003631 , obo:OBI_0003633 .

obo:SO_0000104 a rdfs:Class ;
  rdfs:label "polypeptide" ;
  rdfs:comment "A sequence of amino acids linked by peptide bonds which may lack appreciable tertiary structure and may not be liable to irreversible denaturation." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:CL_0000775 a rdfs:Class ;
  rdfs:label "neutrophil" ;
  rdfs:comment "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." ;
  rdfs:subClassOf obo:CL_0000081 , obo:CL_0000738 .

obo:OBI_0001732 a rdfs:Class ;
  rdfs:label "quenching assay measuring the association constant [KA] of a B cell epitope:antibody complex" ;
  rdfs:comment "A fluorescence quenching assay that measures the association constant [KA] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001635 , obo:OBI_0001719 .

obo:PR_000050353 a rdfs:Class ;
  rdfs:label "aspartate aminotransferase (human)" ;
  rdfs:comment "A protein that is a translation product of any of the following genes in human: GOT1/GOT2." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003515 a rdfs:Class ;
  rdfs:label "vibratory sense assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to sense vibration."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0000542 a rdfs:Class ;
  rdfs:label "gas chromatography equipment" ;
  rdfs:comment "Any device used in a gas chromatography experiment."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0200174 a rdfs:Class ;
  rdfs:label "curve fitting objective"@en ;
  rdfs:comment "A curve fitting objective is a data transformation objective in which the aim is to find a curve which matches a series of data points and possibly other constraints."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:UBERON_0000467 a rdfs:Class ;
  rdfs:label "anatomical system" ;
  rdfs:comment "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0000219 a rdfs:Class ;
  rdfs:label "cellular feature identification objective"@en ;
  rdfs:comment "Cellular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the cellular level, e.g. stage of cell cycle, stage of differentiation."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0002745 a rdfs:Class ;
  rdfs:label "vacuum-assisted biopsy" ;
  rdfs:comment "A biopsy performed with a needle augmented with a vacuum device."@en ;
  rdfs:subClassOf obo:OBI_0002654 .

obo:OBI_0000210 a rdfs:Class ;
  rdfs:label "analytical cytology data file"@en ;
  rdfs:comment "A digital entity intended to capture data in analytical cytology domain."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0002172 a rdfs:Class ;
  rdfs:label "Northwestern blot assay" ;
  rdfs:comment "A direct binding assay that detects interactions of labeled RNA with immobilized protein on a membrane."@en ;
  rdfs:subClassOf obo:OBI_0001591 .

obo:OBI_0000942 a rdfs:Class ;
  rdfs:label "intradermal injection" ;
  rdfs:comment "is the injection of a material entity (bearing the administered substance role) into the dermis (bearing the target role) of an organism using a syringe"@en ;
  rdfs:subClassOf obo:OBI_0000426 , obo:OBI_0600007 .

obo:OBI_0002463 a rdfs:Class ;
  rdfs:label "SIRV RNA spike-in"@en ;
  rdfs:comment "A processed material that consists of transcript isoforms of 7 spike-in RNA variant (SIRV) genes and possibly the 92 External RNA Controls Consortium (ERCC) RNA spike-in genes."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:COB_0000073 a rdfs:Class ;
  rdfs:label "obsolete gene product" .

obo:NCBITaxon_7227 a rdfs:Class ;
  rdfs:label "Drosophila melanogaster" ;
  rdfs:subClassOf obo:NCBITaxon_7147 .

obo:OBI_0001649 a rdfs:Class ;
  rdfs:label "RIA measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A radio immuno assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000910 , obo:OBI_0001703 .

obo:OBI_2100227 a rdfs:Class ;
  rdfs:label "chem11 venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0000437 a rdfs:Class ;
  rdfs:label "analyte measurement objective"@en ;
  rdfs:comment "an assay objective to determine the presence or concentration of an analyte in the evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000441 .

obo:OBI_0002081 a rdfs:Class ;
  rdfs:label "specimens collected longitudinally"@en ;
  rdfs:comment "A collection of specimens that was derived from the same source material entity at different time points in order to observe changes in that entity."@en ;
  rdfs:subClassOf obo:OBI_0002076 .

obo:PATO_0001393 a rdfs:Class ;
  rdfs:label "euploid" ;
  rdfs:comment "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." ;
  rdfs:subClassOf obo:PATO_0001374 .

obo:OBI_0002717 a rdfs:Class ;
  rdfs:label "insecticide resistance time response by bottle assay" ;
  rdfs:comment "An insecticide resistance time response assay that is performed in a glass bottle coated with insecticides, with the presence of a synergist."@en ;
  rdfs:subClassOf obo:OBI_0002709 .

obo:OBI_0002059 a rdfs:Class ;
  rdfs:label "assay measuring a binding constant of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A T cell epitope recognition assay that quantitavely characterizes the binding of a TCR with a ligand by determining a binding constant."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003147 .

obo:OBI_0002740 a rdfs:Class ;
  rdfs:label "organism detection by PCR assay" ;
  rdfs:comment "An organism detection assay that is based on PCR."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0003498 .

obo:OBI_0000250 a rdfs:Class ;
  rdfs:label "dye role"@en ;
  rdfs:comment "A molecular label role which inheres in a material entity and which is realized in the process of detecting a molecular dye that imparts color to some material of interest."@en ;
  rdfs:subClassOf obo:OBI_0002743 .

obo:OBI_2100386 a rdfs:Class ;
  rdfs:label "blood gas arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0001845 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-15 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-15 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001292 .

obo:OBI_0002525 a rdfs:Class ;
  rdfs:label "tibial artery specimen" ;
  rdfs:comment "A specimen that is derived from tibial artery."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0400059 a rdfs:Class ;
  rdfs:label "interrogation_point"@en ;
  rdfs:comment "Point within the fluidic subsystem at which the laser intersects the stream, illuminating the cells where they emit their fluorescence and scatter the light. The laser irradiates the cell at the interrogation point."@en ;
  rdfs:subClassOf obo:BFO_0000029 .

obo:OBI_0500017 a rdfs:Class ;
  rdfs:label "dye swap design" ;
  rdfs:comment "An experiment design type where the label orientations are reversed. exact synonym: flip dye, dye flip"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:CHEBI_35729 a rdfs:Class ;
  rdfs:label "gadolinium molecular entity" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2100295 a rdfs:Class ;
  rdfs:label "free venous blood T4 assay" ;
  rdfs:comment "An analyte assay that measures the abundance of T4 in venous blood as part of a free order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100035 .

obo:OBI_0001669 a rdfs:Class ;
  rdfs:label "far-western blot assay" ;
  rdfs:comment "An assay that measures protein-protein interactions by separating target proteins on an SDS-PAGE gel, transfering them to a solid substrate, hybridizing with a protein probe and visualizing bound proteins using a probe-directed antibody. This is a adaptation on the western blot assay."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:SO_0005836 a rdfs:Class ;
  rdfs:label "regulatory_region" ;
  rdfs:comment "A region of sequence that is involved in the control of a biological process." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:PR_000034459 a rdfs:Class ;
  rdfs:label "luciferase-like monooxygenase" ;
  rdfs:comment "A protein that is a translation product of the Escherichia coli K-12 yhbW gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0001839 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001280 .

obo:OBI_0001463 a rdfs:Class ;
  rdfs:label "transcription profiling by array assay" ;
  rdfs:comment "A transcription profiling assay that uses array technology."@en ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_0002091 a rdfs:Class ;
  rdfs:label "5' rapid amplification of cDNA ends"@en ;
  rdfs:comment "A rapid amplication of cDNA ends to amplify a mRNA sequence between a defined internal site and the 5' end of the mRNA."@en ;
  rdfs:subClassOf obo:OBI_0002090 .

obo:OBI_0001052 a rdfs:Class ;
  rdfs:label "two-photon laser/detector" ;
  rdfs:comment "A light source used in fluorescence imaging that allows the imaging of living tissue up to a depth of 1 mm, based on the concept that two photons of low energy can excite a fluorophore in a quantum event, resulting in the emission of a fluorescence photon, typically at a higher energy than either of the two excitatory photons."@en ;
  rdfs:subClassOf obo:OBI_0400065 .

obo:GO_0032633 a rdfs:Class ;
  rdfs:label "interleukin-4 production" ;
  rdfs:comment "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:IAO_0000429 a rdfs:Class ;
  rdfs:label "email address"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0001582 a rdfs:Class ;
  rdfs:label "obsolete cell bound MHC direct binding assay" ;
  rdfs:comment "direct binding assay measuring MHC ligand binding using MHC derived from a cell"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003413 a rdfs:Class ;
  rdfs:label "administering substance in vivo to cause disease" ;
  rdfs:comment "An administration of substance in vivo with the intention to induce disease in the organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0001444 a rdfs:Class ;
  rdfs:label "genotyping design" ;
  rdfs:comment "A study design that classifies an individual or group of individuals on the basis of alleles, haplotypes, SNPs."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0000397 a rdfs:Class ;
  rdfs:label "image acquisition function"@en ;
  rdfs:comment "An image acquisition function is a function to acquire an image of a material"@en ;
  rdfs:subClassOf obo:OBI_0000453 .

obo:OBI_0001074 a rdfs:Class ;
  rdfs:label "cryofixation device" ;
  rdfs:comment "A device that is used for the fixation or stabilization of biological materials as the first step in specimen preparation for electron microscopy."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:MRO_0001465 a rdfs:Class ;
  rdfs:label "pig MHC class I protein complex" ;
  rdfs:subClassOf obo:MRO_0001355 .

obo:OBI_0001253 a rdfs:Class ;
  rdfs:label "assay measuring interleukin-9 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_2100104 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood monocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of monocytes in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003025 , obo:OBI_0003040 .

obo:OBI_0000539 a rdfs:Class ;
  rdfs:label "imaging NMR probe" ;
  rdfs:comment "An NMR probe that is designed for generating pictures from sample states via NMR imaging."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_0001694 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific induction of hypersensitivity" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that detects a hypersensitivity response by monitoring skin reactions."@en ;
  rdfs:subClassOf obo:OBI_0001178 , obo:OBI_0001698 .

obo:OBI_0003349 a rdfs:Class ;
  rdfs:label "T2 weighted FLAIR magnetic resonance image data set" ;
  rdfs:comment "A T2 weighted image data set collected using a FLAIR sequence."@en ;
  rdfs:subClassOf obo:OBI_0003348 .

obo:OBI_2000001 a rdfs:Class ;
  rdfs:label "urethra specimen" ;
  rdfs:comment "A specimen that is derived from some urethra"@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0003605 a rdfs:Class ;
  rdfs:label "single molecule fluorescence in situ hybridization" ;
  rdfs:comment "A fluorescence in-situ hybridization assay that detects single RNA molecules in fixed cells, allowing for both the quantification and localization at the single-cell level and single-molecule resolution."@en ;
  rdfs:subClassOf obo:OBI_0003094 .

obo:OBI_2000014 a rdfs:Class ;
  rdfs:label "venous blood specimen" ;
  rdfs:comment "A specimen that is derived from some venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0100058 a rdfs:Class ;
  rdfs:label "xenograft"@en ;
  rdfs:comment "A material entity which results from the transplantation of living cells, tissues or organs  from on organism of one species to an organism of another species."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:GO_0019882 a rdfs:Class ;
  rdfs:label "antigen processing and presentation" ;
  rdfs:comment "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_2100397 a rdfs:Class ;
  rdfs:label "venous blood beta-2-microglobulin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of beta-2-microglobulin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0000933 a rdfs:Class ;
  rdfs:label "positron emission tomography scanner" ;
  rdfs:comment "A device that produces a three-dimensional image or picture of functional processes in the body. It detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0002966 a rdfs:Class ;
  rdfs:label "microenvironment microarray assay" ;
  rdfs:comment "A type of cytometry assay where cells are incubated for three days with a standardized set of extracellular matrix proteins in combination with various ligands creating varying microenvironment perterbations for the cells. Immunofluorescent imaging of cells is used to measure features such as morphology, metabolism, cell cycle, and nuclear activity."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0200026 a rdfs:Class ;
  rdfs:label "total intensity transformation single"@en ;
  rdfs:comment "A total intensity transformation single is a data transformation that takes as input an n-dimensional (real) vector and multiplies each component of this vector by a coefficient, where the coefficient is obtained by taking the sum of the input components or of a subset of these, multiplied by a constant of choice."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0002452 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interferon-alpha production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interferon-alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:PATO_0001344 a rdfs:Class ;
  rdfs:label "alpha mating type (yeast)" ;
  rdfs:comment "A S. cerevisiae mating type cells that secrete a pheromone that stimulates a haploids." ;
  rdfs:subClassOf obo:PATO_0001342 .

obo:OBI_0002960 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based reporter gene assay" ;
  rdfs:comment "A type of reporter gene assay that employs fluorescence imaging to detect a reporter gene's expression."@en ;
  rdfs:subClassOf obo:OBI_0002082 .

obo:UBERON_0000002 a rdfs:Class ;
  rdfs:label "uterine cervix" ;
  rdfs:comment "Lower, narrow portion of the uterus where it joins with the top end of the vagina." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001390 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interferon-beta production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interferon-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0003230 a rdfs:Class ;
  rdfs:label "T cell activation induced marker assay" ;
  rdfs:comment "A flow cytometry assay that detects the presence/amount of antigen-specific T cells without the need to identify their cytokine production. Instead, antigen-specific T cells are detected on the basis of upregulation of TCR stimulation-induced surface markers."@en ;
  rdfs:subClassOf obo:OBI_0000916 .

obo:COB_0000049 a rdfs:Class ;
  rdfs:label "nucleic acid chain"@en ;
  rdfs:comment "A molecule that consists of nucleotides (unmodified nucleotide residues and/or modified nucleotide residues) linked by phosphodiester bonds or derivatives of such bonds."@en ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_1000029 a rdfs:Class ;
  rdfs:label "phage display library"@en ;
  rdfs:comment "a phage display library is a collection of materials in which a mixture of genes or gene fragments is expressed and can be individually selected and amplified."@en ;
  rdfs:subClassOf obo:OBI_0000731 .

obo:OBI_0002751 a rdfs:Class ;
  rdfs:label "Oxford Nanopore GridION Mk1" ;
  rdfs:comment "A DNA sequencer that is manufactured by the Oxford Nanopore Technologies corporation, that can run and analyze up to five individual flow cells producing up to 150 Gb of data per run. The sequencer produces real-time results and utilizes nanopore technology with the option of running the flow cells concurrently or individually."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0002183 a rdfs:Class ;
  rdfs:label "two electrode voltage clamp assay" ;
  rdfs:comment "The two electrode voltage clamp (TEVC) method utilizes two low-resistance pipettes, one sensing voltage and the other injecting current. The microelectrodes are filled with conductive solution and inserted into the cell to artificially control membrane potential. The membrane acts as a dielectric as well as a resistor, while the fluids on either side of the membrane function as capacitors.[9] The microelectrodes compare the membrane potential against a command voltage, giving an accurate reproduction of the currents flowing across the membrane. Current readings can be used to analyze the electrical response of the cell to different applications. This technique is mainly used in the Oocyte preparation."@en ;
  rdfs:subClassOf obo:OBI_0002182 .

obo:OBI_0000802 a rdfs:Class ;
  rdfs:label "prothrombin time assay" ;
  rdfs:comment "An assay that measures the prothrombin ratio, which is the prothrombin time for a patient, divided by the result for control plasma. Most commonly the test is preformed using blood plasma. Blood is drawn into a test tube containing liquid citrate, which acts as an anticoagulant. An excess of calcium is added to enable the blood to clot again.Tissue factor (also known as factor III or thromboplastin) is added, and the time the sample takes to clot is measured optically as the prothrombin time, which is compared to a control sample."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0032907 a rdfs:Class ;
  rdfs:label "transforming growth factor beta3 production" ;
  rdfs:comment "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000192 a rdfs:Class ;
  rdfs:label "microtiter plate" ;
  rdfs:comment "A microtiter_plate is a flat plate with multiple wells used as small test tubes."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0001221 a rdfs:Class ;
  rdfs:label "ChIP-chip by SNP array assay" ;
  rdfs:comment "A ChIP-ChIP assay in which immunoprecipitated chromatin is run on a SNP array to detect polymorphism specific DNA elements in the isolated chromatin"@en ;
  rdfs:subClassOf obo:OBI_0001248 .

obo:OBI_0000439 a rdfs:Class ;
  rdfs:label "agarose gel"@en ;
  rdfs:comment "a material entity resulting from the polymerization of agarose after heating agarose suspended in some buffer solution"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000690 a rdfs:Class ;
  rdfs:label "immunoprecipitation" ;
  rdfs:comment "is a process which realizes a material separation objective by relying on antibodies to specifically binding to material entity"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:CL_0002193 a rdfs:Class ;
  rdfs:label "myelocyte" ;
  rdfs:comment "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:CHEBI_39026 a rdfs:Class ;
  rdfs:label "low-density lipoprotein" ;
  rdfs:comment "A class of lipoproteins of small size (18-25 nm) and low density (1.019-1.063 g/ml) particles with a core composed mainly of cholesterol esters and smaller amounts of triglycerides. The surface monolayer consists mostly of phospholipids, a single copy of apolipoprotein B-100, and free cholesterol molecules. The main function of LDL is to transport cholesterol and cholesterol esters from the liver. Excessive levels are associated with cardiovascular disease." ;
  rdfs:subClassOf obo:CHEBI_6495 .

obo:OBI_0600007 a rdfs:Class ;
  rdfs:label "administering substance in vivo"@en ;
  rdfs:comment "A process by which a substance is intentionally given to an organism resulting in exposure of the organism to that substance."@en ;
  rdfs:subClassOf obo:OBI_0000274 .

obo:OBI_0002686 a rdfs:Class ;
  rdfs:label "counter current immunoelectrophoresis" ;
  rdfs:comment "An electrophoresis in which antigen and antibody move in opposite directions and form precipitates in the area between the cells where they meet in concentrations of optimal proportions."@en ;
  rdfs:subClassOf obo:OBI_0600053 .

obo:OBI_2100231 a rdfs:Class ;
  rdfs:label "chem11 venous blood magnesium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of magnesium in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100021 .

obo:GO_0001047 a rdfs:Class ;
  rdfs:subClassOf obo:OBI_0001588 .

obo:OBI_0003398 a rdfs:Class ;
  rdfs:label "Affymetrix Human Gene 2.0 ST Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, which provides the most accurate, sensitive, and comprehensive measurement of protein coding (mRNA) and long intergenic non-coding RNA (lincRNA) transcripts. The array design covers >33,500 coding transcripts and >11,000 lincRNA transcripts thus enabling researchers to understand whole-transcriptome gene expression at the gene and exon levels, which allows the study of transcript variants and alternative splicing events."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0200073 a rdfs:Class ;
  rdfs:label "family wise error rate correction method"@en ;
  rdfs:comment "A family wise error rate correction method is a multiple testing procedure that controls the probability of at least one false positive."@en ;
  rdfs:subClassOf obo:OBI_0200089 .

obo:OBI_0100061 a rdfs:Class ;
  rdfs:label "primary cultured cell population"@en ;
  rdfs:comment "A cultured cell population comprised of cells expanded directly from living tissue prior to being passaged."@en ;
  rdfs:subClassOf obo:OBI_0100060 .

obo:OBI_1110015 a rdfs:Class ;
  rdfs:label "Immunization in vivo"@en ;
  rdfs:comment "Process of administering an object playing the role of immunogen to a living organism"@en ;
  rdfs:subClassOf obo:OBI_1110094 .

obo:OBI_0000476 a rdfs:Class ;
  rdfs:label "manual injection system" ;
  rdfs:comment "The traditional hardware system that allows a human to inject a sample into an inlet by hand, using a syringe."@en ;
  rdfs:subClassOf obo:OBI_0000504 .

obo:OBI_0003475 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An in vivo assay measuring a B cell epitope specific protection from a pathogen challenge after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001179 , obo:OBI_0002638 .

obo:CL_0000578 a rdfs:Class ;
  rdfs:label "experimentally modified cell in vitro" ;
  rdfs:comment "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_1110179 a rdfs:Class ;
  rdfs:label "MHC tetramer/multimer assay measuring binding of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A MHC tetramer/multimer assay that measures the binding of an epitope:MHC complex binding with a T cell receptor."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001501 , obo:OBI_1110124 .

obo:OBI_0400052 a rdfs:Class ;
  rdfs:label "helium cadmium ion laser" ;
  rdfs:comment "A helium-cadmium laser is a metal vapor laser that emits wavelengths of 442, 325 and 354 nms. This laser is a metal vapor laser. A helium-cadmium laser can by used to irradiate cells in a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400073 .

obo:OBI_0003692 a rdfs:Class ;
  rdfs:label "case-control investigation"@en ;
  rdfs:comment "An investigation that has participants that bear either a case or control role and which examines the hypothesis that the presence of the outcome in case participants is associated with an exposure that is not associated with control participants."@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_0000376 a rdfs:Class ;
  rdfs:label "synthesizing function"@en ;
  rdfs:comment "A synthesizing function is a function to assemble new output materials from distinct input materials.  The output materials typically consist of chemically distinct monomeric objects or object aggregate polymers."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:NCBITaxon_3702 a rdfs:Class ;
  rdfs:label "Arabidopsis thaliana" ;
  rdfs:subClassOf obo:NCBITaxon_2759 .

obo:OBI_0003768 a rdfs:Class ;
  rdfs:label "pregnancy assessment based on tissue morphology assay" ;
  rdfs:comment "A histological assay that measures the number of implantation sites in an organism."@en ;
  rdfs:subClassOf obo:OBI_0600020 .

obo:OBI_0003635 a rdfs:Class ;
  rdfs:label "antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex" ;
  rdfs:comment "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003616 .

obo:OBI_1110056 a rdfs:Class ;
  rdfs:label "epitope specific IL-2 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-2 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032623 , obo:OBI_0001193 .

obo:CL_0000232 a rdfs:Class ;
  rdfs:label "erythrocyte" ;
  rdfs:comment "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." ;
  rdfs:subClassOf obo:CL_0000081 .

obo:OBI_0002194 a rdfs:Class ;
  rdfs:label "Microm Ergostar HM200" ;
  rdfs:comment "A microtome that is manufactured by Microm and uses a vertical cutting stroke common to all rotary microtomes engaged by a horizontal sliding movement. An operating arm replaces the handwheel and is attached to both sides of the instrument for greater convenience to permit control of sectioning from the left or right."@en ;
  rdfs:subClassOf obo:OBI_0400168 .

obo:OBI_0002014 a rdfs:Class ;
  rdfs:label "DNA methylation profiling by ChIP-chip assay" ;
  rdfs:comment "An epigenetic modification assay that identifies sites of DNA methylation using ChIP-chip technologies."@en ;
  rdfs:subClassOf obo:OBI_0001248 , obo:OBI_0002020 .

obo:OBI_0400149 a rdfs:Class ;
  rdfs:label "protein microarray" ;
  rdfs:comment "A protein-microarray is a microarray, ususlly a piece of glass, on which different molecules of protein have been affixed at separate locations in an ordered manner. These are used to identify protein-protein or protein-small molecule interactions."@en ;
  rdfs:subClassOf obo:OBI_0400147 .

obo:OBI_0003138 a rdfs:Class ;
  rdfs:label "enhancer-trap mutagenesis" ;
  rdfs:comment "A transgenic mutagenesis that produces a mutation by introducing a construct designed to monitor transcriptionally active regions when inserted into the genome of an organism by inserting a reporter gene that requires cis-acting DNA sequences in the genome to activate reporter gene expression."@en ;
  rdfs:subClassOf obo:OBI_0003136 .

obo:COB_0000005 a rdfs:Class ;
  rdfs:label "obsolete elementary charge" .

obo:OBI_0100026 a rdfs:Class ;
  rdfs:label "obsolete organism" ;
  rdfs:comment "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002503 a rdfs:Class ;
  rdfs:label "feces specimen" ;
  rdfs:comment "A specimen that is derived from feces."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001209 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-10 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002953 a rdfs:Class ;
  rdfs:label "protein state assay" ;
  rdfs:comment "A type of assay that measures the quantity and/or identity of proteins in their modficied and unmodified states where modifications include phosphorylation, methylation, acetylation, etc."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001991 a rdfs:Class ;
  rdfs:label "assay measuring the half maximal effective concentration [EC50] of a MHC:ligand complex" ;
  rdfs:comment "A MHC binding constant determination assay measuring half maximal effective concentration (EC50)."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003145 .

obo:OBI_0003435 a rdfs:Class ;
  rdfs:label "acyl-CoA oxidase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of Acyl-CoA oxidase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_2100368 a rdfs:Class ;
  rdfs:label "automated count venous blood reticulocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of reticulocytes in venous blood as part of a automated count order"@en ;
  rdfs:subClassOf obo:OBI_0003026 , obo:OBI_0003040 .

obo:OBI_0003097 a rdfs:Class ;
  rdfs:label "liquid chromatography mass spectrometry assay" ;
  rdfs:comment "A mass spectrometry assay where a sample mixture is first separated by liquid chromatography before being converted into ions which are characterized by using mass spectrometry based on their mass-to-charge ratio and relative abundance."@en ;
  rdfs:subClassOf obo:OBI_0000470 .

obo:OBI_0001541 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring binding on rate [kon] to determine direct binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay measuring binding on rate (kon) to detect direct binding of a purified-MHC:ligand complex."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001994 .

obo:IAO_0000574 a rdfs:Class ;
  rdfs:label "assigning a centrally registered identifier"@en ;
  rdfs:comment "A planned process in which a new CRID is created, associated with an entity, and stored in the CRID registry thereby registering it as being associated with some entity"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0200191 a rdfs:Class ;
  rdfs:label "gene list visualization" ;
  rdfs:comment "Adata visualization which has input of a gene list and produces an output of a report graph which is capable of rendering data of this type."@en ;
  rdfs:subClassOf obo:OBI_0200111 .

obo:OBI_0001402 a rdfs:Class ;
  rdfs:label "promoter activity detection by reporter gene assay measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "A promoter activity detection by reporter gene assay that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000913 , obo:OBI_0001445 .

obo:OBI_0001885 a rdfs:Class ;
  rdfs:label "specimen repository organization"@en ;
  rdfs:comment "An organization that provides a service to store and distribute specimens"@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0003320 a rdfs:Class ;
  rdfs:label "granulysin release during T cell degranulation" ;
  rdfs:comment "The release of granulysin during cytotoxic T cell degranulation."@en ;
  rdfs:subClassOf obo:GO_0036262 .

obo:OBI_0000809 a rdfs:Class ;
  rdfs:label "amplified DNA" ;
  rdfs:comment "DNA that has been produced in an enzymatic amplification process"@en ;
  rdfs:subClassOf obo:CHEBI_16991 .

obo:OBI_0000441 a rdfs:Class ;
  rdfs:label "assay objective"@en ;
  rdfs:comment "an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role)"@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0001867 a rdfs:Class ;
  rdfs:label "establishing cell line" ;
  rdfs:comment "a process whereby a new type of cell line is created, either through passaging of a primary cell culture to relative genetic stability and compositional homogeneity, or through some experimental modification of an existing cell line to produce a new line with novel characteristics  (e.g. immortalization or some other stable genetic modification, or selection of some defined subset)."@en ;
  rdfs:subClassOf obo:OBI_0600036 .

obo:OBI_0200072 a rdfs:Class ;
  rdfs:label "curve fitting data transformation"@en ;
  rdfs:comment "A curve fitting is a data transformation that has objective curve fitting and that consists of finding a curve which matches a series of data points and possibly other constraints."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0001096 a rdfs:Class ;
  rdfs:label "laser capture microdissection microscope" ;
  rdfs:comment "A microscope that uses low-energy laser beams and special transfer film to lift single cells from a tissue."@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:UBERON_0002048 a rdfs:Class ;
  rdfs:label "lung" ;
  rdfs:comment "Respiration organ that develops as an outpocketing of the esophagus." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0001809 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific granzyme A release by T cells" ;
  rdfs:comment "A T cell epitope specific cytotoxic T cell degranulation assay that detects granzyme A release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001269 .

obo:OBI_0001057 a rdfs:Class ;
  rdfs:label "high performance liquid chromatography instrument" ;
  rdfs:comment "A liquid chromatography instrument that consists of a reservoir of mobile phase, a pump, an injector, a separation column, and a detector. The pump (rather than gravity) provides the higher pressure required to propel the mobile phase and analyte through the densely packed column."@en ;
  rdfs:subClassOf obo:OBI_0001139 .

obo:OBI_0000950 a rdfs:Class ;
  rdfs:label "paraffin specimen" ;
  rdfs:comment "a specimen that is output of a paraffin storage process in which specimen is embedded in paraffin"@en ;
  rdfs:subClassOf obo:OBI_0001472 , obo:OBI_0100051 .

obo:OBI_0001755 a rdfs:Class ;
  rdfs:label "selection criterion"@en ;
  rdfs:comment "A directive information entity which defines and states a principle of standard by which selection process may take place."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0003741 a rdfs:Class ;
  rdfs:label "capillary electrophoresis mass spectrometry assay" ;
  rdfs:comment "A mass spectrometry assay where a sample mixture is first separated by capillary electrophoresis before being analysed by mass spectrometry."@en ;
  rdfs:subClassOf obo:OBI_0000470 .

obo:OBI_0001231 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects transforming growth factor-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001264 .

obo:OBI_0000840 a rdfs:Class ;
  rdfs:label "unblinding process" ;
  rdfs:comment "A planned process that is the part of the study execution in which the subjects are told what study arm they are in and in which the investigators are told which subjects are in which trials."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000936 a rdfs:Class ;
  rdfs:label "obsolete_material access provider role" ;
  rdfs:comment "a service provider role which is realized by a servicer provider organization performing access to some material"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001964 a rdfs:Class ;
  rdfs:label "decision-theoretic analysis objective" ;
  rdfs:comment "An objective specification which what includes a description of two or more alternative actions to take in a particular situation and a metric that enables comparisons of the two actions. The objective specified is achieved in a planned process which includes a data transformation, the output of which is an identification of the 'best' choice according to the metric."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_2100187 a rdfs:Class ;
  rdfs:label "arterial blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_0001418 a rdfs:Class ;
  rdfs:label "dose response design" ;
  rdfs:comment "A study design that examines the relationship between the size of the administered dose and the extent of the response."@en ;
  rdfs:subClassOf obo:OBI_0000951 .

obo:OBI_2100375 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0000400 a rdfs:Class ;
  rdfs:label "display function"@en ;
  rdfs:comment "A display function is a function to present information by translating that information through some lookup process into visual form."@en ;
  rdfs:subClassOf obo:OBI_0000392 .

obo:OBI_2100047 a rdfs:Class ;
  rdfs:label "C-reactive protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of C-reactive protein"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:OBI_2100002 a rdfs:Class ;
  rdfs:label "sodium(1+) assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium(1+)"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003360 a rdfs:Class ;
  rdfs:label "image segmentation map" ;
  rdfs:comment "An image data set of integer values in which each value corresponds to some shared characteristic or computed property. The values often belong to a group of pixels or voxels that share the same characteristic, such as a tissue type or anatomical region."@en ;
  rdfs:subClassOf obo:OBI_0003333 .

obo:OBI_0002420 a rdfs:Class ;
  rdfs:label "exposure to silica history" ;
  rdfs:comment "An exposure to environmental and workplace carcinogens history where the carcinogen is silica."@en ;
  rdfs:subClassOf obo:OBI_0002415 .

obo:OBI_0001350 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001414 .

obo:OBI_0500012 a rdfs:Class ;
  rdfs:label "graeco latin square design" ;
  rdfs:comment "Greco-Latin square design is a study design which relates to Latin square design"@en ;
  rdfs:subClassOf obo:OBI_0500007 .

obo:OBI_2100273 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0400063 a rdfs:Class ;
  rdfs:label "LactoScope C4" ;
  rdfs:comment "A LactoScope_C4 is a spectrophotometer with which the composition of milk and milk products is analysed via infrared technology. The LactoScope determines the amount of the constituents fat, protein, lactose and the total solids content with extreme accuracy."@en ;
  rdfs:subClassOf obo:OBI_0400115 .

obo:OBI_0003464 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific survival after pathogen challenge" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from pathogen challenge using survival."@en ;
  rdfs:subClassOf obo:OBI_0003457 , obo:OBI_0003460 .

obo:OBI_0003613 a rdfs:Class ;
  rdfs:label "electron microscopy assay determining the 3D structure of a MHC:ligand complex" ;
  rdfs:comment "An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a MHC:ligand complex."@en ;
  rdfs:subClassOf obo:OBI_0002050 , obo:OBI_0003118 .

obo:OBI_0002921 a rdfs:Class ;
  rdfs:label "artificial pit shelter" ;
  rdfs:comment "An arthropod trap, consisting of a pit dug in the ground to provide a space for arthropods to rest and be collected."@en ;
  rdfs:subClassOf obo:OBI_0002939 .

obo:OBI_0002489 a rdfs:Class ;
  rdfs:label "differential medium assay" ;
  rdfs:comment "An organism detection assay that uses a differential medium to achieve its objective."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0001705 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific antigen inhibition of antibody activity" ;
  rdfs:comment "A B cell epitope dependent biological activity determination assay that detects inhibition of the antibody's activity by the antigen."@en ;
  rdfs:subClassOf obo:OBI_0001706 .

obo:PO_0025131 a rdfs:Class ;
  rdfs:label "plant anatomical entity" ;
  rdfs:comment "An anatomical entity that is or was part of a plant." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_0002474 a rdfs:Class ;
  rdfs:label "material sequencing library preparation role"@en ;
  rdfs:comment "A worker role played by the person who performs the library preparation process to generate a sequencing library for a sample to be sequenced."@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:OBI_0000703 a rdfs:Class ;
  rdfs:label "Illumina Genome Analyzer II" ;
  rdfs:comment "is a DNA sequence which is manufactured by Illumina (Solexa) corporation. it support sequencing of single or paired end clone libraries relying on sequencing by synthesis technology"@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_2000004 a rdfs:Class ;
  rdfs:label "eye specimen" ;
  rdfs:comment "A specimen that is derived from some eye"@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100087 a rdfs:Class ;
  rdfs:label "basic metabolic panel venous blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in venous blood as part of a basic metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_0002449 a rdfs:Class ;
  rdfs:label "footprinting assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A footprinting assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001703 , obo:OBI_0002162 .

obo:OBI_0003376 a rdfs:Class ;
  rdfs:label "droplet-based single-cell RNA sequencing assay" ;
  rdfs:comment "A single-cell transcription profiling by RNA sequencing assay that analyzes mRNA transcripts from droplets of individual cells. The process involves the following steps: (1) prepare a single-cell suspension from a tissue; (2) co-encapsulate each cell with a distinctly barcoded microparticle (bead) in a nanoliter-scale droplet; (3) lyse cells after they have been isolated in droplets; (4) capture a cell’s mRNAs on its companion microparticle, forming STAMPs (single-cell transcriptomes attached to microparticles); (5) reverse-transcribe, amplify, and sequence."@en ;
  rdfs:subClassOf obo:OBI_0002631 .

obo:PATO_0001348 a rdfs:Class ;
  rdfs:label "F minus mating type" ;
  rdfs:comment "A bacterial mating type indicating the absence of F plasmid in a bacterial cell." ;
  rdfs:subClassOf obo:PATO_0001335 .

obo:OBI_0001218 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-8 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-8 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0000242 a rdfs:Class ;
  rdfs:label "software testing objective"@en ;
  rdfs:comment "Software_testing_objective is a hardware_optimization role describing a study designed to examine the effects of using different software or software parameters, e.g. data processing software."@en ;
  rdfs:subClassOf obo:OBI_0000208 .

obo:OBI_2100091 a rdfs:Class ;
  rdfs:label "basic metabolic panel venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood as part of a basic metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0001851 a rdfs:Class ;
  rdfs:label "transcription start site identification objective"@en ;
  rdfs:comment "A transcription profiling identification objective that aims to characterize the transcription start sites of genes."@en ;
  rdfs:subClassOf obo:OBI_0001331 .

obo:OBI_0000676 a rdfs:Class ;
  rdfs:label "reduced dimension data set"@en ;
  rdfs:comment "A data set that is produced as the output of a data vector reduction data transformation and consists of producing a data set which has fewer vectors than the input data set."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0001085 a rdfs:Class ;
  rdfs:label "radiography instrument" ;
  rdfs:comment "An image acquisition device that uses ionizing electromagnetic radiation such as X-rays to view objects."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0002767 a rdfs:Class ;
  rdfs:label "amplicon sequencing assay" ;
  rdfs:comment "A sequencing assay in which a DNA or RNA input molecule is amplified by PCR and the product sequenced."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_0200100 a rdfs:Class ;
  rdfs:label "canonical variate analysis"@en ;
  rdfs:comment "canonical variate analysis is a form of discriminant analysis that takes several continuous predictor variables and uses the entire set to predict several criterion variables, each of which is also continuous. CVA simultaneously calculates a linear composite of all x variables and  a linear composite of all y variables. Unlike other multivariate techniques, these weighted composites are derived in pairs. Each linear combination is called a canonical variate and takes the general linear form."@en ;
  rdfs:subClassOf obo:OBI_0200106 , obo:OBI_0200171 .

obo:OBI_0200008 a rdfs:Class ;
  rdfs:label "hyperlog transformation"@en ;
  rdfs:comment "A hyperlog transformation ia a data transformation that, for each (one dimensional) real number input x, outputs an approximation (found, e.g. with the Newton's method) to a solution y of the equation EH(y)-x=0, where EH denotes an eh transformation."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0002781 a rdfs:Class ;
  rdfs:label "lower respiratory tract aspirate specimen" ;
  rdfs:comment "A specimen that is collected with a suctioning tube from the lower respiratory tract."@en ;
  rdfs:subClassOf obo:OBI_0002783 .

obo:OBI_0003777 a rdfs:Class ;
  rdfs:label "absorbance quality detection assay" ;
  rdfs:comment "An assay that measures the absorbance quality of the evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:CHEBI_25078 a rdfs:Class ;
  rdfs:label "luciferin" ;
  rdfs:comment "A low-molecular-mass compound present in bioluminescent organisms that emits light when oxidized in presence of enzyme luciferase." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000665 a rdfs:Class ;
  rdfs:label "obsolete intracellular cytokine staining assay" ;
  rdfs:comment "The measurement of cytokines within the cytoplasm of a cell by permeabilizing the cell membrane to allow entry of specific antibodies, and counting the stained cells using a flow cytometer."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_1110116 a rdfs:Class ;
  rdfs:label "splenocyte specimen" ;
  rdfs:comment "A cell specimen comprised of a mixed cell population obtained by processing whole spleen into individual cells, typically performed using a sieve or blender. This population includes T cells, B cells, macrophages, and other cell types."@en ;
  rdfs:subClassOf obo:OBI_0001468 .

obo:OBI_0001112 a rdfs:Class ;
  rdfs:label "autoclave" ;
  rdfs:comment "A device that is used to sterilize equipment and supplies by subjecting them to high pressure steam at 121 C or more, typically for 15 to 20 minutes depending on the size of the load and the contents."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_0001788 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects tumor necrosis factor superfamily cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001400 .

obo:OBI_0003338 a rdfs:Class ;
  rdfs:label "task-based functional magnetic resonance image data set" ;
  rdfs:comment "A type of functional MRI in which the participant is given a task or tasks, which are timed with the acquisition"@en ;
  rdfs:subClassOf obo:OBI_0003336 .

obo:UBERON_0005022 a rdfs:Class ;
  rdfs:label "mucosa of nasopharynx" ;
  rdfs:comment "A mucosa that is part of a nasopharynx [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OPL_0000267 a rdfs:Class ;
  rdfs:label "Plasmodium gametocyte" ;
  rdfs:comment "A Plasmodium that is located either in the bloodstream of the vertebrate host or midgut of mosquito vector during gametocyte stage. Gametocytes are the precursor cells of the macro- or microgametes" ;
  rdfs:subClassOf obo:NCBITaxon_5820 .

obo:OBI_0000523 a rdfs:Class ;
  rdfs:label "magic angle spinning rotor" ;
  rdfs:comment "A rotor device that holds the NMR sample and enables the adjustment of the orientation of the rotation axis for a sample in a NMR instrument in the magic angle."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:UBERON_0007311 a rdfs:Class ;
  rdfs:label "sputum" ;
  rdfs:comment "Matter ejected from the lungs, bronchi, and trachea, through the mouth." ;
  rdfs:subClassOf obo:UBERON_0006538 .

obo:OBI_0003525 a rdfs:Class ;
  rdfs:label "stance on one foot assessment" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance on one foot."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:UBERON_0002371 a rdfs:Class ;
  rdfs:label "bone marrow" ;
  rdfs:comment "The soft tissue that fills the cavities of bones." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:OBI_0001407 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific T cell activation" ;
  rdfs:comment "A T cell epitope dependent biological activity assay that detects T cell activation."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002055 .

obo:OBI_0000227 a rdfs:Class ;
  rdfs:label "data encoding"@en ;
  rdfs:comment "a documenting process to encode an information entity into a digital document"@en ;
  rdfs:subClassOf obo:IAO_0000572 .

obo:OBI_0002907 a rdfs:Class ;
  rdfs:label "aquatic arthropod specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process that has the objective of collecting mosquitoes from an aquatic environment."@en ;
  rdfs:subClassOf obo:OBI_0002913 .

obo:OBI_0000528 a rdfs:Class ;
  rdfs:label "liquid chromatography valve" ;
  rdfs:comment "A sample valve that must be able to sustain pressures up to 10,000 p.s.i., although it is most likely to operate on a continuous basis, at pressures of 3,000 p.s.i. or less. The higher the operating pressure the tighter the valve seating surfaces must be forced together to eliminate any leak. It follows that any abrasive material, however fine, that passes into the valve can cause the valve seating to become scored each time it is rotated which will ultimately lead to leaks. This will cause the sample size to vary between samples and eventually affect the accuracy of the analysis. It follows that any solid material must be carefully removed from any sample before filling the valve. The sample volume of an internal loop valve is situated in the connecting slot of the valve rotor and can be used only for relatively small sample volumes. Internal sample loop valves provide samples with volumes ranging from 0.1 ml to about 0.5 ml. Valve operation is shown in figure 6. The left-hand side diagram shows the load position. The sample occupies the rotor slot and has been filled by passing the sample from an appropriate syringe through the rotor slot to waste. While loading the sample, the mobile phase supply is passed through the valve directly to the column. To place the sample onto the column, the valve is then rotated and the valve slot containing the sample is now placed between the solvent supply and the column. As a result, the sample is passed into the column by the flow of solvent."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:PR_000000001 a rdfs:Class ;
  rdfs:label "protein" ;
  rdfs:comment "An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." ;
  rdfs:subClassOf obo:CHEBI_16670 , obo:PR_000018263 .

obo:OBI_0001387 a rdfs:Class ;
  rdfs:label "genotyping by array design" ;
  rdfs:comment "A study design that classifies an individual or group of individuals on the basis of alleles, haplotypes, SNPs using microarray technology."@en ;
  rdfs:subClassOf obo:OBI_0001444 .

obo:OBI_0002392 a rdfs:Class ;
  rdfs:label "exposure to second hand smoke in current household" ;
  rdfs:comment "An exposure to second hand smoke in person's current household."@en ;
  rdfs:subClassOf obo:OBI_0002390 .

obo:IAO_0000037 a rdfs:Class ;
  rdfs:label "dot plot"@en ;
  rdfs:comment "A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions."@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:UBERON_0002389 a rdfs:Class ;
  rdfs:label "manual digit" ;
  rdfs:comment "A digit that is part of a manus (hand)." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_1110201 a rdfs:Class ;
  rdfs:label "allergen" ;
  rdfs:comment "A material entity bearing the disposition to cause an allergic reaction"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:CL_0000001 a rdfs:Class ;
  rdfs:label "primary cultured cell" ;
  rdfs:comment "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." ;
  rdfs:subClassOf obo:CL_0000010 .

obo:OBI_0002730 a rdfs:Class ;
  rdfs:label "pathogen detection by Rapid Analyte Measurement Platform assay" ;
  rdfs:comment "A pathogen detection assay that is based on Rapid Analyte Measurement Platform (RAMP) technology to quantify immunologically active substances."@en ;
  rdfs:subClassOf obo:OBI_0002728 .

obo:OBI_0002586 a rdfs:Class ;
  rdfs:label "digital acquisition card" ;
  rdfs:comment "The digital acquisition card acts as the interface between the computer and a measurement device via the computer bus. It converts the signal generated by a measurement device (output from device) to a digital signal via an analog-to-digital converter, ADC. It also converts a digital signal to an analog signal via a digital-to-analog converter, DAC. This analog signal (e.g., stimulus) is fed to a measurement device (input to device)."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000492 a rdfs:Class ;
  rdfs:label "Bruker B-ACS system" ;
  rdfs:comment "The Bruker Automatic Sample Changer (B-ACS 60/120), used in conjunction with Bruker DISNMR, UXNMR or XWIN-NMR software, provides dialog-guided facilities which allow the user to easily and effectively perform automatic (continuous) experiments. Features include a 60 or 120 sample capacity, random accessing of samples, positive sample identification with the optional bar code reader, and temperature control of individual samples with the optional sample heater unit."@en ;
  rdfs:subClassOf obo:OBI_0000464 .

obo:OBI_2100363 a rdfs:Class ;
  rdfs:label "creatinine clearance urine creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in urine as part of a creatinine clearance order"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100003 .

obo:OBI_2100132 a rdfs:Class ;
  rdfs:label "count venous blood reticulocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of reticulocytes in venous blood as part of a count order"@en ;
  rdfs:subClassOf obo:OBI_0003026 , obo:OBI_0003040 .

obo:CL_0000814 a rdfs:Class ;
  rdfs:label "mature NK T cell" ;
  rdfs:comment "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." ;
  rdfs:subClassOf obo:CL_0000789 .

obo:OBI_0002648 a rdfs:Class ;
  rdfs:label "individual organism specimen" ;
  rdfs:comment "A specimen composed of an individual organism to be studied in an investigation."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0001029 a rdfs:Class ;
  rdfs:label "OH-radical structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay hat determines nucleic acid secondary structure at a nucleotide resolution scale using hydroxyl radical as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0002706 a rdfs:Class ;
  rdfs:label "topical application insecticide resistance bioassay" ;
  rdfs:comment "An insecticide resistance bioassay by adding insecticide directly to the thorax of the insect."@en ;
  rdfs:subClassOf obo:OBI_0002698 .

obo:OBI_0003387 a rdfs:Class ;
  rdfs:label "Illumina NextSeq 550" ;
  rdfs:comment "A DNA sequencer manufactured by the Illumina corporation, which provides the increased flexibility of microarray scanning in addition to sequencing."@en ;
  rdfs:subClassOf obo:OBI_0003684 .

obo:OBI_0000534 a rdfs:Class ;
  rdfs:label "tecmag NMR instrument" ;
  rdfs:comment "An NMR instrument that is manufactured by tecmag."@en ;
  rdfs:subClassOf obo:OBI_0000566 .

obo:OBI_0000784 a rdfs:Class ;
  rdfs:label "anticoagulant-containing test tube" ;
  rdfs:comment "A 'blue top' test tube that contains anticoagulant for storing blood specimens'"@en ;
  rdfs:subClassOf obo:OBI_0000836 .

obo:OBI_0000274 a rdfs:Class ;
  rdfs:label "adding a material entity into a target"@en ;
  rdfs:comment "is a process with the objective to place a material entity bearing the 'material to be added role' into a material bearing the 'target of material addition role'."@en ;
  rdfs:subClassOf obo:OBI_0000652 .

obo:OBI_0002724 a rdfs:Class ;
  rdfs:label "insecticide resistance by PCR amplification of specific alleles assay" ;
  rdfs:comment "An insecticide resistance assay that is based on monitoring known mutations by PCR amplification of specific alleles to detect polymorphic or mutant alleles."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0002696 .

obo:OBI_1110099 a rdfs:Class ;
  rdfs:label "L cell line"@en ;
  rdfs:comment "A cell line derived from mouse fibroblasts."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:MRO_0001455 a rdfs:Class ;
  rdfs:label "human MHC class II protein complex" ;
  rdfs:subClassOf obo:MRO_0001356 .

obo:OBI_0002731 a rdfs:Class ;
  rdfs:label "pathogen detection by loop-mediated isothermal amplification assay" ;
  rdfs:comment "A pathogen detection assay that is based on loop-mediated isothermal amplification."@en ;
  rdfs:subClassOf obo:OBI_0002728 .

obo:OBI_0003753 a rdfs:Class ;
  rdfs:label "regulation of synapse maturation assay" ;
  rdfs:comment "A cell differentiation assay that measures synapse formation and maturation using antibodies to protein found in synaptic puncta."@en ;
  rdfs:subClassOf obo:OBI_0003720 .

obo:OGMS_0000031 a rdfs:Class ;
  rdfs:label "disease" ;
  rdfs:comment "A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_0002756 a rdfs:Class ;
  rdfs:label "ordinal value specification"@en ;
  rdfs:comment "A categorical value specification in which the available categories were created with an explicit order."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0000465 a rdfs:Class ;
  rdfs:label "organic acid column" ;
  rdfs:comment "An organic acid column is a chromatography column which enables (reversed-phase) separation of hydrophilic aliphatic and aromatic organic acids with UV detection. Organic acid columns allow retention of polar and apolar organic acids and are hydrolysis resistant."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0000671 a rdfs:Class ;
  rdfs:label "sample from organism" ;
  rdfs:comment "a material obtained from an organism in order to be a representative of the whole"@en ;
  rdfs:subClassOf obo:OBI_0000747 , obo:OBI_0001479 .

obo:OBI_0002057 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific macrophage migration inhibitory factor (MIF) production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects macrophage migration inhibitory factor (MIF) production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001069 a rdfs:Class ;
  rdfs:label "array manufacturer role"@en ;
  rdfs:comment "a manufacturer role which is played by the person or organization that manufactured the array"@en ;
  rdfs:subClassOf obo:OBI_0000571 .

obo:OBI_0001260 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-3 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001406 .

obo:OBI_0001620 a rdfs:Class ;
  rdfs:label "latitude coordinate measurement datum"@en ;
  rdfs:comment "A measurement datum that is the measure of the latitude coordinate of a site."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0002408 a rdfs:Class ;
  rdfs:label "patch delivery form for hormonal replacement therapy" ;
  rdfs:comment "A delivery form for hormonal replacement therapy that is a patch for transdermal administration."@en ;
  rdfs:subClassOf obo:OBI_0002406 .

obo:OBI_0002799 a rdfs:Class ;
  rdfs:label "personal protective glove" ;
  rdfs:comment "A personal protective device which is a glove."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_1110007 a rdfs:Class ;
  rdfs:label "administration in vivo with infectious agent" ;
  rdfs:comment "is an administration of an infectious agent to a host organism"@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0200040 a rdfs:Class ;
  rdfs:label "modular decomposition"@en ;
  rdfs:comment "Molecular decomposition is the partition of a network into distinct subgraphs for the purpose of identifying functional clusters. The network data is run through any of several existing algorithms designed to partition a network into distinct subgraphs for the purpose of isolating groups of functionally linked biological elements such as proteins."@en ;
  rdfs:subClassOf obo:OBI_0200080 .

obo:IAO_0000101 a rdfs:Class ;
  rdfs:label "image"@en ;
  rdfs:comment "An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface."@en ;
  rdfs:subClassOf obo:IAO_0000308 .

obo:OBA_2060187 a rdfs:Class ;
  rdfs:label "knee joint functionality" ;
  rdfs:comment "The functionality of a knee joint." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:OBI_0002068 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific oncostatin M production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects oncostatin M production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0002058 , obo:OBI_0003115 .

obo:GO_0033036 a rdfs:Class ;
  rdfs:label "macromolecule localization" ;
  rdfs:comment "Any process in which a macromolecule is transported to, or maintained in, a specific location." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003699 a rdfs:Class ;
  rdfs:label "clinical trial"@en ;
  rdfs:comment "A clinical investigation that involves an intervention."@en ;
  rdfs:subClassOf obo:OBI_0003697 .

obo:OBI_0003424 a rdfs:Class ;
  rdfs:label "alanine aminotransferase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of alanine aminotransferase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:GO_0140779 a rdfs:Class ;
  rdfs:label "XCL1 production" ;
  rdfs:comment "The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0002375 a rdfs:Class ;
  rdfs:label "daughter clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a person's female child."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0002673 a rdfs:Class ;
  rdfs:label "enrichment culture medium" ;
  rdfs:comment "A culture medium that is designed to favor the growth of a particular microorganism or cells over others, enriching a sample for the microorganism or cells of interest."@en ;
  rdfs:seeAlso <https://github.com/obi-ontology/obi/issues/997> ;
  rdfs:subClassOf obo:OBI_0000079 .

obo:OBI_0001249 a rdfs:Class ;
  rdfs:label "epitope specific T cell tolerance induction" ;
  rdfs:comment "A process of T cell tolerance induction resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0002517 , obo:OBI_0001201 .

obo:OBI_0001790 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific RANTES production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects RANTES production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001232 , obo:OBI_0600031 .

obo:OBI_0200180 a rdfs:Class ;
  rdfs:label "spread calculation objective"@en ;
  rdfs:comment "is a data transformation objective whereby the aim is to the calculate the spread of a dataset, spread is a descriptive statistic which describes the variability of values in a data set."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_1110087 a rdfs:Class ;
  rdfs:label "donor role"@en ;
  rdfs:comment "A role which inheres in an organism or part thereof from which any part including cell, organ or tissue is removed with the intention that the donated part will be placed into another organism and/or cultured in vitro."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002762 a rdfs:Class ;
  rdfs:label "single-nucleus ATAC-seq" ;
  rdfs:comment "An ATAC-seq assay in which single nuclei are isolated from frozen tissue samples, through a protocol designed to maximally preserve nucleus integrity during sample processing and optimize transposase-mediated fragmentation of chromatin in individual nuclei."@en ;
  rdfs:subClassOf obo:OBI_0002039 .

obo:OBI_0000040 a rdfs:Class ;
  rdfs:label "drug role"@en ;
  rdfs:comment "a role borne by a molecular entity and is realized in a process of absorption by an organism  alters, or effects  (or is assumed to effect) a function(s) which inhere in an organism"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003720 a rdfs:Class ;
  rdfs:label "cell differentiation assay" ;
  rdfs:comment "A cytometry assay that monitors the differentiation stage of cells in culture."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0001710 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from challenge" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that uses a epitope protection experiment."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0001698 .

obo:OBI_0002914 a rdfs:Class ;
  rdfs:label "human-biting arthropod specimen collection by aspiration" ;
  rdfs:comment "An arthropod specimen collection by aspiration that occurs while the arthropod is biting a human."@en ;
  rdfs:subClassOf obo:OBI_0002912 .

obo:OBI_0003019 a rdfs:Class ;
  rdfs:label "promyelocyte assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of promyelocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000185 a rdfs:Class ;
  rdfs:label "imaging assay" ;
  rdfs:comment "An assay that produces a picture of an entity."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003508 a rdfs:Class ;
  rdfs:label "dysmetria assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to accurately touch a moving target with their finger and then touch their own chin a number of times in a row."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0001638 a rdfs:Class ;
  rdfs:label "antigen inhibition assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex approximated by IC50" ;
  rdfs:comment "A B cell epitope equilibrium dissociation constant (KD) assay that provides IC50 values determined under assay conditions where the IC50 approximates a KD value using a B cell epitope antigen inhibition of binding assay."@en ;
  rdfs:subClassOf obo:OBI_0001708 .

obo:OBI_0000571 a rdfs:Class ;
  rdfs:label "manufacturer role" ;
  rdfs:comment "Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001530 a rdfs:Class ;
  rdfs:label "data service" ;
  rdfs:comment "A service that has some information content entity as input and output."@en ;
  rdfs:subClassOf obo:OBI_0001173 .

obo:OBI_0002560 a rdfs:Class ;
  rdfs:label "family status inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states one or more family statuses, which, if met, makes a human being suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0200200 a rdfs:Class ;
  rdfs:label "chi square test" ;
  rdfs:comment "The chi-square test is a data transformation with the objective of statistical hypothesis testing, in which the sampling distribution of the test statistic is a chi-square distribution when the null hypothesis is true, or any in which this is asymptotically true, meaning that the sampling distribution (if the null hypothesis is true) can be made to approximate a chi-square distribution as closely as desired by making the sample size large enough."@en ;
  rdfs:subClassOf obo:OBI_0000673 .

obo:OBI_2100284 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0001896 a rdfs:Class ;
  rdfs:label "investigation assay specification"@en ;
  rdfs:comment "A plan specification which indicates the assay type used to obtain data."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0003707 a rdfs:Class ;
  rdfs:label "mortar and pestle device" ;
  rdfs:comment "A device which is a set of two tools used to crush or grind material into smaller particles. A mortar is used to contain the material, and a pestle is a handheld blunt object used to apply force to the material."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_1110185 a rdfs:Class ;
  rdfs:label "epitope specific IFN-g release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IFNg resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032609 , obo:OBI_0001193 .

obo:OBI_0002200 a rdfs:Class ;
  rdfs:label "cannot be assessed determination" ;
  rdfs:comment "A reason for lack of data item that is the negative output of a determination if assay will provide reliable results."@en ;
  rdfs:subClassOf obo:OBI_0002199 .

obo:OBI_0000021 a rdfs:Class ;
  rdfs:label "list-mode data file"@en ;
  rdfs:comment "A list-mode data file is a binary digital entity where events are stored sequentially, parameter by parameter."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003127 a rdfs:Class ;
  rdfs:label "B cell epitope assay" ;
  rdfs:comment "An immune epitope assay that characterizes the structrue of an antibody-epitope complex, or measures the binding of an antibody receptor to epitope, or the immune response process resulting from such a binding event or the recognition of the epitope."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110128 .

obo:CL_0000836 a rdfs:Class ;
  rdfs:label "promyelocyte" ;
  rdfs:comment "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:CHEBI_28001 a rdfs:Class ;
  rdfs:label "vancomycin" ;
  rdfs:comment "A complex glycopeptide from <em>Streptomyces orientalis</em>. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria <em>Staphylococcus aureus</em> and <em>Clostridium difficile</em>." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002381 a rdfs:Class ;
  rdfs:label "grandmother clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female parent of a parent."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:PR_000050331 a rdfs:Class ;
  rdfs:label "lactate dehydrogenase complex" ;
  rdfs:comment "A protein-containing complex that is composed of four subunits of L-lactate dehydrogenase, cytoplasmic." ;
  rdfs:subClassOf obo:GO_0032991 .

obo:OBI_0000481 a rdfs:Class ;
  rdfs:label "chromatography detector" ;
  rdfs:comment "A chromatography detector is a device that locates in the dimensions of space and time, the positions of the components of a mixture that has been subjected to a chromatographic process and thus permits the senses to appreciate the nature of the separation.  Defining characteristics are Dynamic Range, Response Index or Linearity, Linear Dynamic range, Detector Response,  Detector Noise Level, Detector Sensitivity or Minimum Detectable Concentration, Total System Dispersion, Sensor Dimensions, Detector Time Constant, Pressure Sensitivity, Flow Sensitivity, Operating Temperature Range."@en ;
  rdfs:subClassOf obo:OBI_0000485 .

obo:OBI_0002020 a rdfs:Class ;
  rdfs:label "epigenetic modification assay" ;
  rdfs:comment "An assay that identifies epigenetic modifications including histone modifications, open chromatin, and DNA methylation."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:UBERON_0006538 a rdfs:Class ;
  rdfs:label "respiratory system fluid/secretion" ;
  rdfs:comment "A portion of organism substance that secreted_by a respiratory system." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OBI_0200103 a rdfs:Class ;
  rdfs:label "multiple linear regression analysis"@en ;
  rdfs:comment """multiple linear regression is a regression method that models the relationship between a dependent variable Y, independent variables Xi, i = 1, ..., p, and a random term epsilon. The model can be written as
    Y = \\beta_0 + \\beta_1 X_1 + \\beta_2 X_2 + \\cdots +\\beta_p X_p + \\varepsilon
where \\beta_0 =  0 is the intercept (\"constant\" term), the \\beta_i s  are the respective parameters of independent variables, and p is the number of parameters to be estimated in the linear regression."""@en ;
  rdfs:subClassOf obo:OBI_0200102 .

obo:OBI_0003166 a rdfs:Class ;
  rdfs:label "neutrophil percentage assay" ;
  rdfs:comment "A neutrophil assay that measures the percentage of neutrophils in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003022 .

obo:GO_0006915 a rdfs:Class ;
  rdfs:label "apoptotic process" ;
  rdfs:comment "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0302893 a rdfs:Class ;
  rdfs:label "storage"@en ;
  rdfs:comment "A planned process with the objective to preserve and protect material entities by placing them in an identified location which may have a controlled environment."@en ;
  rdfs:subClassOf obo:OBI_0000838 .

obo:OBI_0001336 a rdfs:Class ;
  rdfs:label "quality control testing design" ;
  rdfs:comment "A study design in which some aspects of the experiment is quality controlled for the purposes of quality assurance."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0600048 a rdfs:Class ;
  rdfs:label "vector mediated amplification"@en ;
  rdfs:comment "The process of creating a copy of some biological entity in cell culture"@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_0003476 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific pathogen protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on survival" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using survival."@en ;
  rdfs:subClassOf obo:OBI_0003468 , obo:OBI_0003475 .

obo:CL_0000624 a rdfs:Class ;
  rdfs:label "CD4-positive, alpha-beta T cell" ;
  rdfs:comment "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." ;
  rdfs:subClassOf obo:CL_0000789 .

obo:OBI_0000014 a rdfs:Class ;
  rdfs:label "regulator role"@en ;
  rdfs:comment "a regulatory role involved with making and/or enforcing relevant legislation and governmental orders"@en ;
  rdfs:subClassOf obo:OBI_0000017 .

obo:OBI_0003008 a rdfs:Class ;
  rdfs:label "trap for emerging adult arthropods" ;
  rdfs:comment "An arthropod trap that is designed to trap an arthropod as it emerges from water at the beginning of its adult stage."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0002575 a rdfs:Class ;
  rdfs:label "isoform sequencing" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay for sequencing isoforms by enriching a cDNA library for full-length reads spanning entire transcript isoforms."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:CHEBI_16670 a rdfs:Class ;
  rdfs:label "peptide" ;
  rdfs:comment "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from α-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." ;
  rdfs:subClassOf obo:CHEBI_33839 .

obo:OBI_0001299 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-5 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-5 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001230 .

obo:OBI_0001766 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific vascular endothelial growth factor production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects vascular endothelial growth factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001570 .

obo:OBI_0400155 a rdfs:Class ;
  rdfs:label "water bath" ;
  rdfs:comment "A water bath is a temperature control bath in which a water acts as contact medium enabling temperature transfer from the heating element or cooling element to the sample. The temperature can be controlled in the 0 to 100 degree centigrade range (under normal pressure)."@en ;
  rdfs:subClassOf obo:OBI_0400120 .

obo:OBI_0001820 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-X-C motif) ligand 16 production by T cells" ;
  rdfs:comment "A process of chemokine (C-X-C motif) ligand 16 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0097392 , obo:OBI_0001193 .

obo:OBI_0001952 a rdfs:Class ;
  rdfs:label "flash freezing"@en ;
  rdfs:comment "A freezing process by which material entities are quickly frozen by subjecting them to cryogenic temperatures, or in direct contact with Liquid nitrogen at -320.8F or -196°C."@en ;
  rdfs:subClassOf obo:OBI_0001953 .

obo:OBI_0001242 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific tumor necrosis factor alpha production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects tumor necrosis factor alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001416 , obo:OBI_0001788 .

obo:OBI_0001361 a rdfs:Class ;
  rdfs:label "transcription profiling by RT-PCR assay" ;
  rdfs:comment "A transcription profiling assay that uses reverse transcription PCR (RT-PCR)."@en ;
  rdfs:subClassOf obo:OBI_0000424 , obo:OBI_0002692 .

obo:OBI_2100289 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0000096 a rdfs:Class ;
  rdfs:label "protocol testing objective"@en ;
  rdfs:comment "Protocol_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different protocols."@en ;
  rdfs:subClassOf obo:OBI_0000208 .

obo:OBI_0002546 a rdfs:Class ;
  rdfs:label "liver specimen" ;
  rdfs:comment "A specimen that is derived from liver."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002701 a rdfs:Class ;
  rdfs:label "insecticide resistance by detecting acetylcholinesterase activity assay" ;
  rdfs:comment "An insecticide resistance by detecting enzyme activity assay that measures activity of acetylcholinesterase."@en ;
  rdfs:subClassOf obo:OBI_0002697 .

obo:OBI_0001138 a rdfs:Class ;
  rdfs:label "X-ray source" ;
  rdfs:comment "A device that is used to generate X-rays."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0200010 a rdfs:Class ;
  rdfs:label "loess scale group transformation one-channel"@en ;
  rdfs:comment "A loess scale group transformation one-channel is a loess scale group transformation consisting in the application of a scale adjustment following a loess group transformation one-channel, to render the M group variances similar."@en ;
  rdfs:subClassOf obo:OBI_0200025 .

obo:MRO_0001454 a rdfs:Class ;
  rdfs:label "human MHC class I protein complex" ;
  rdfs:subClassOf obo:MRO_0001355 .

obo:OBI_0400032 a rdfs:Class ;
  rdfs:label "differential pressure gauge" ;
  rdfs:comment "Part of the fluidics subsystem. The differential pressure gauge monitors the difference between sample and sheath fluid pressures in systems where pressure is used to force the sample fluid to flow in the center of the sheath fluid. A differential pressure gauge can be used by the operator to make sure that the sample fluid is at a greater pressure than the sheath fluid, which maintains a core of sample fluid."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001011 a rdfs:Class ;
  rdfs:label "ENU structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines the secondary structure of a nucleic acid at the nucleotide resolution scale which uses ENU as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0302733 a rdfs:Class ;
  rdfs:label "solute role"@en ;
  rdfs:comment "solute role is a role played by a chemical entity which is dissolved by another chemical entity (the solvent) when creating a solution"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003837 a rdfs:Class ;
  rdfs:label "action potential interval assay" ;
  rdfs:comment "An electrophysiology assay that measures the time elapsed between the peaks of consecutive action potential spikes in a neuron burst."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0002176 .

obo:OBI_0200058 a rdfs:Class ;
  rdfs:label "b cell epitope prediction"@en ;
  rdfs:comment "A B cell epitope prediction takes as input an antigen sequence, and through an analysis of this sequence, produces as output a prediction of the likelihood the biomaterial is a B Cell Epitope."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_0302847 a rdfs:Class ;
  rdfs:label "methylated polymer"@en ;
  rdfs:comment "A methylated polymer which has artificially acquired one or more methyl groups"@en ;
  rdfs:subClassOf obo:CHEBI_33839 .

obo:OBI_0003641 a rdfs:Class ;
  rdfs:label "antibody purification of HLA protein complex with DQ3 serotype" ;
  rdfs:comment "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with DQ3 serotype, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003638 .

obo:OBI_0001920 a rdfs:Class ;
  rdfs:label "DNA replication timing by sequencing assay" ;
  rdfs:comment "An assay in which timing of DNA replication is quantified as a function of genome position based on genome-wide sequencing."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_0003488 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects tumor necrosis factor superfamily cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001400 .

obo:CL_2000001 a rdfs:Class ;
  rdfs:label "peripheral blood mononuclear cell" ;
  rdfs:comment "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." ;
  rdfs:subClassOf obo:CL_0000842 .

obo:OBI_0002423 a rdfs:Class ;
  rdfs:label "age of majority inclusion criterion" ;
  rdfs:comment "An inclusion criterion that uses the age of majority for a state or institution, where one is generally considered to be an adult, which if met, makes an individual suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:CL_0000084 a rdfs:Class ;
  rdfs:label "T cell" ;
  rdfs:comment "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." ;
  rdfs:subClassOf obo:CL_0000542 .

obo:OBI_0200111 a rdfs:Class ;
  rdfs:label "data visualization"@en ;
  rdfs:comment "A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002792 a rdfs:Class ;
  rdfs:label "patient gown" ;
  rdfs:comment "A personal protective clothing item which is a gown designed for use by a patient to facilitate caregiving by medical staff."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_0001325 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific RANTES production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects RANTES production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001232 .

obo:UBERON_0036149 a rdfs:Class ;
  rdfs:label "suprapubic skin" ;
  rdfs:comment "Area of skin in the hypoastric region of the abdomen." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0400065 a rdfs:Class ;
  rdfs:label "light source" ;
  rdfs:comment "A light source is an optical subsystem that provides light for use in a distant area using a delivery system (e.g., fiber optics). Light sources may include one of a variety of lamps (e.g., xenon, halogen, mercury). Most light sources are operated from line power, but some may be powered from batteries. They are mostly used in endoscopic, microscopic, and other examination and/or in surgical procedures. The light source is part of the optical subsystem. In a flow cytometer the light source directs high intensity light at particles at the interrogation point. The light source in a flow cytometer is usually a laser."@en ;
  rdfs:subClassOf obo:OBI_0001032 .

obo:UBERON_0000995 a rdfs:Class ;
  rdfs:label "uterus" ;
  rdfs:comment "The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:REO_0000280 a rdfs:Class ;
  rdfs:label "obsolete molecular label" ;
  rdfs:comment "A molecular reagent intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003032 a rdfs:Class ;
  rdfs:label "genotyping by PCR assay" ;
  rdfs:comment "A genotyping assay that uses polymerase chain reaction."@en ;
  rdfs:subClassOf obo:OBI_0000435 , obo:OBI_0002692 .

obo:OBI_0000253 a rdfs:Class ;
  rdfs:label "artificially induced nucleic acid hybridization"@en ;
  rdfs:comment "Is a material transformation in which strands of nucleic acids that are (somewhat) complementary form a double-stranded molecule. Has input at least two single stranded molecules of nucleic acid molecules."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001545 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects macrophage inflammatory protein-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001333 .

obo:OBI_0001721 a rdfs:Class ;
  rdfs:label "3D molecular structure determination assay of an antigen:antibody complex" ;
  rdfs:comment "A 3D structure determination of bound molecular complex assay that characterizes the 3-dimensional structure of an antigen:antobody complex."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001145 , obo:OBI_0003127 .

obo:OBI_0002557 a rdfs:Class ;
  rdfs:label "maximum age value specification"@en ;
  rdfs:comment "A value specifcation that specifies the oldest age when specifying an age range."@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_0003316 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific amphiregulin production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects amphiregulin production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0003315 .

obo:OBI_2100198 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0200095 a rdfs:Class ;
  rdfs:label "exponential transformation"@en ;
  rdfs:comment "An exponential transformation is a data transformation consisting in the application of the exponential function with a given base a (where a>0 and a is typically not equal to 1) to a (one dimensional) real number input. For alternative definitions and properties of this function see, e.g., http://en.wikipedia.org/wiki/Exponential_function and http://en.wikipedia.org/wiki/Characterizations_of_the_exponential_function."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0003618 a rdfs:Class ;
  rdfs:label "antibody purification of HLA protein complex with A2 serotype" ;
  rdfs:comment "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003617 , obo:OBI_0003620 .

obo:OBI_0001619 a rdfs:Class ;
  rdfs:label "specimen collection time measurement datum"@en ;
  rdfs:comment "A time measurement datum that is the measure of the time when the specimens are collected."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_2100150 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0001127 a rdfs:Class ;
  rdfs:label "freeze substitution system" ;
  rdfs:comment "A device or system for dehydrating and then chemically fixing electron microscopy samples at low temperatures in preparation for various treatments including embedding in resins."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:MRO_0002026 a rdfs:Class ;
  rdfs:label "H2-Dq protein complex" ;
  rdfs:subClassOf obo:MRO_0001460 .

obo:OBI_0003119 a rdfs:Class ;
  rdfs:label "antigen:antibody complex" ;
  rdfs:comment "A complex of molecular entitites which is the result of an antibody binding to an antigen."@en ;
  rdfs:subClassOf obo:COB_0000080 .

obo:OBI_2000018 a rdfs:Class ;
  rdfs:label "leukocyte specimen" ;
  rdfs:comment "A specimen that is derived from some leukocytes"@en ;
  rdfs:subClassOf obo:OBI_0001468 .

obo:OBI_0002729 a rdfs:Class ;
  rdfs:label "VectorTest assay" ;
  rdfs:comment "A pathogen detection assay that identifies the presence or absence of specific peptide epitopes of circumsporozoite (CS) protein of the most important Plasmodium falciparum and two strains (variants 210 and 247) of the more widespread Plasmodium vivax using a dipstick wicking test strip."@en ;
  rdfs:subClassOf obo:OBI_0002728 .

obo:OBI_2100137 a rdfs:Class ;
  rdfs:label "random electrolytes urine sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in urine as part of a random electrolytes order"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100002 .

obo:OBI_0001783 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects monocyte chemotactic protein-1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001465 .

obo:OBI_0001903 a rdfs:Class ;
  rdfs:label "email address of specimen provider principal investigator"@en ;
  rdfs:comment "An email address of the principal investigator providing the specimens for the investigation"@en ;
  rdfs:subClassOf obo:IAO_0000429 .

obo:GO_0032616 a rdfs:Class ;
  rdfs:label "interleukin-13 production" ;
  rdfs:comment "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0200062 a rdfs:Class ;
  rdfs:label "continuum mass spectrum analysis"@en ;
  rdfs:comment "A continuum mass spectrum is a data transformation that contains the full profile of the detected signals for a given ion."@en ;
  rdfs:subClassOf obo:OBI_0200085 .

obo:OBI_1110127 a rdfs:Class ;
  rdfs:label "assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope assay that measures the binding of an antibody receptor to an epitope."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003127 .

obo:OBI_0200083 a rdfs:Class ;
  rdfs:label "survival analysis objective"@en ;
  rdfs:comment "A data transformation objective which has the data transformation aims to model time to event data (where events are e.g. death and or disease recurrence); the purpose of survival analysis is to model the underlying distribution of event times and to assess the dependence of the event time on other explanatory variables"@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:MRO_0001461 a rdfs:Class ;
  rdfs:label "mouse MHC class II protein complex" ;
  rdfs:subClassOf obo:MRO_0001356 .

obo:OBI_0001777 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 22 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-C motif) ligand 22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001603 a rdfs:Class ;
  rdfs:label "binding off rate measurement datum (koff)" ;
  rdfs:comment "A rate measurement datum of how quickly bound complexes disassociate"@en ;
  rdfs:subClassOf obo:OBI_0001144 , obo:OBI_0001554 .

obo:OBI_0001993 a rdfs:Class ;
  rdfs:label "assay measuring the off rate measurement [koff] of a MHC:ligand complex" ;
  rdfs:comment "A MHC binding constant determination assay measuring binding off rate measurement data item (koff)."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001553 .

obo:OBI_0003609 a rdfs:Class ;
  rdfs:label "disease prevention objective"@en ;
  rdfs:comment "An objective specification that is fulfilled by preventing the development of a disease in a particular organism."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0000813 a rdfs:Class ;
  rdfs:label "to be treated with active ingredient role" ;
  rdfs:comment "A study subject role which begins to exist when a subject is assigned to be one of those who will receive active ingredient, and is realized in a study execution in which they receive the active ingredient"@en ;
  rdfs:subClassOf obo:OBI_0000097 .

obo:OBI_0002042 a rdfs:Class ;
  rdfs:label "carbon-copy chromosome conformation capture assay followed by sequencing assay" ;
  rdfs:comment "A carbon-copy chromosome conformation capture assay to analyze the organization of chromosomes in an unbiased, genome-wide manner using high throughput sequening following carbon-copy chromosome conformation capture."@en ;
  rdfs:subClassOf obo:OBI_0001919 .

obo:PATO_0002204 a rdfs:Class ;
  rdfs:label "ambidextrous handedness" ;
  rdfs:comment "Handedness where the organism exhibits no overall dominance in the use of right or left hand or foot in the performance of tasks that require one hand or foot or a dominant hand or foot." ;
  rdfs:subClassOf obo:PATO_0002201 .

obo:OBI_0000474 a rdfs:Class ;
  rdfs:label "nano pump system" ;
  rdfs:comment "A pump system optimized for nano flow chromatography."@en ;
  rdfs:subClassOf obo:OBI_0000589 .

obo:OBI_0001874 a rdfs:Class ;
  rdfs:label "random access memory size"@en ;
  rdfs:comment "random access memory size is a scalar measurement datum which denotes the amount of physical memory know as random access memory present of a computer or required by a computational process or data transformation"@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0001090 a rdfs:Class ;
  rdfs:label "multimode microplate reader" ;
  rdfs:comment "A microplate reader that can detect multiple types of absorbance, luminescence or fluorescence."@en ;
  rdfs:subClassOf obo:OBI_0001058 .

obo:OBI_0000602 a rdfs:Class ;
  rdfs:label "column frit" ;
  rdfs:comment "A part of the column content that separates column packing compartments. In radial columns the packing is supported between two cylindrical frits and the gap between represents the bed height or column length. The outer frit is the column inlet and consequently the sample initially has a large area of stationary phase with which to interact. Frits are porous metal products to prevent unwanted particles from entering the chromatography system. These particles may come from the sample, the solvent or debris generated by the chromatography system itself. Such particles entering the system may lead to clogging of capillaries, interference with the chromatography by changing chromatographic parameters or disturbance of the detector function. Characteristics of a frit, besides the diameter and the thickness, is the porosity (pore distribution, density)."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:PATO_0000011 a rdfs:Class ;
  rdfs:label "age" ;
  rdfs:comment "A time quality inhering in a bearer by virtue of how long the bearer has existed." ;
  rdfs:subClassOf obo:PATO_0000165 .

obo:UBERON_0000057 a rdfs:Class ;
  rdfs:label "urethra" ;
  rdfs:comment "The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0002943 a rdfs:Class ;
  rdfs:label "sticky resting bucket" ;
  rdfs:comment "An arthropod trap that consists of a bucket, which is lined with adhesive and placed on its side, and a wet cloth inside the bucket. The placement of the box and modifications to it are done in such a way that it becomes attractive to an arthropod as a place to rest during a period of inactivity. The trap is designed for arthropods to become caught in the adhesive so that they can be collected."@en ;
  rdfs:subClassOf obo:OBI_0002939 .

obo:OBI_0001535 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-7 production by T cells" ;
  rdfs:comment "A process of interleukin-7 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032636 , obo:OBI_0001193 .

obo:OBI_0000589 a rdfs:Class ;
  rdfs:label "chromatography pump system" ;
  rdfs:comment "Better flow rates can be achieved by using a pump or by using compressed gas (e.g. air, nitrogen, or argon) to push the solvent through the column (flash column chromatography)."@en ;
  rdfs:subClassOf obo:OBI_0000485 .

obo:OBI_0000434 a rdfs:Class ;
  rdfs:label "adding material objective"@en ;
  rdfs:comment "is the specification of an objective to add a material into a target material. The adding is asymmetric in the sense that the target material largely retains its identity"@en ;
  rdfs:subClassOf obo:OBI_0000686 .

obo:OBI_0000996 a rdfs:Class ;
  rdfs:label "device creation objective" ;
  rdfs:comment "an objective which aims to create a device with a specified function"@en ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:OBI_0002637 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that uses a epitope protection experiment after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0002073 , obo:OBI_0002676 .

obo:OBI_0000115 a rdfs:Class ;
  rdfs:label "intervention design" ;
  rdfs:comment "An intervention design is a study design in which a controlled process applied to the subjects (the intervention) serves as the independent variable manipulated by the experimentalist. The treatment (perturbation or intervention) defined can be defined as a combination of values taken by independent variable manipulated by the experimentalists are applied to the recruited subjects assigned (possibly by applying specific methods) to treatment groups. The specificity of intervention design is the fact that independent variables are being manipulated and a response of the biological system is evaluated via response variables as monitored by possibly a series of assays."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_2100357 a rdfs:Class ;
  rdfs:label "venous blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0000234 a rdfs:Class ;
  rdfs:label "trial statistician role"@en ;
  rdfs:comment "a worker role that analyzes data obtained during a trial or study; this role occurs after the trial or study is completed or terminated."@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:OBI_0001498 a rdfs:Class ;
  rdfs:label "atmosphere"@en ;
  rdfs:comment "A growth environment pertaining to the atmospheric conditions that is used to culture or grow an organism."@en ;
  rdfs:subClassOf obo:OBI_0000997 .

obo:OBI_0003237 a rdfs:Class ;
  rdfs:label "feces assay" ;
  rdfs:comment "An assay that has a feces specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003188 a rdfs:Class ;
  rdfs:label "nucleated erythrocyte percentage assay" ;
  rdfs:comment "An erythrocyte assay that measures the percentage of nucleated erythrocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003190 .

obo:OBI_0000660 a rdfs:Class ;
  rdfs:label "background corrected data set"@en ;
  rdfs:comment "A data set that is produced as the output of a background correction data transformation."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0003108 a rdfs:Class ;
  rdfs:label "single-nucleus chromatin accessibility and mRNA expression sequencing assay" ;
  rdfs:comment "An assay that involves joint profiling of accessible chromatin and RNA within the same cells which enables direct matching of transcriptional regulation to its outputs."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002742 a rdfs:Class ;
  rdfs:label "organism detection by salinity tolerance assay" ;
  rdfs:comment "An organism detection assay of mosquito species that is on the basis of mosquito survival depending on the salt concentration in the water used to lay their eggs to differentiate between morphologically very similar species."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:CHEBI_30682 a rdfs:Class ;
  rdfs:label "ruthenium atom" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2100381 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_2100129 a rdfs:Class ;
  rdfs:label "inpatient profile venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a inpatient profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:GO_0009987 a rdfs:Class ;
  rdfs:label "cellular process" ;
  rdfs:comment "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001953 a rdfs:Class ;
  rdfs:label "freezing"@en ;
  rdfs:comment "A planned process with the objective to bring some material entity to a temperature below its freezing point."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002015 a rdfs:Class ;
  rdfs:label "transcription profiling by MPSS assay" ;
  rdfs:comment "A transcription profiling assay that uses Massive Parallel Signature Sequencing (MPSS)."@en ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_2100069 a rdfs:Class ;
  rdfs:label "liver injury venous blood human alkaline phosphatase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a liver injury order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100017 .

obo:OBI_0003289 a rdfs:Class ;
  rdfs:label "mosquito membrane feeding device" ;
  rdfs:comment "A device that contains blood in a membrane penetrable to mosquitoes, designed to feed mosquitoes without the need for an animal host."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001154 a rdfs:Class ;
  rdfs:label "induced mutagenesis"@en ;
  rdfs:comment "A genetic transformation that is the modification of the genetic material (either coding or non-coding) of an organism caused by mutagenic processes, compounds, or irradiation."@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_2100161 a rdfs:Class ;
  rdfs:label "venous blood LDH assay" ;
  rdfs:comment "An assay that measures LDH in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100028 .

obo:OBI_0003519 a rdfs:Class ;
  rdfs:label "sitting posture assessment" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain unsupported posture while sitting over a given time period."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0002467 a rdfs:Class ;
  rdfs:label "alignment counting application"@en ;
  rdfs:comment "A software application that implements an alignment counting algorithm, used to count the overlap of aligned sequencing reads with genes."@en ;
  rdfs:subClassOf obo:IAO_0000594 .

obo:OBI_0000577 a rdfs:Class ;
  rdfs:label "obsolete_molecular concentration" ;
  rdfs:comment "A concentration is a relational quality that inheres in a material entity towards molecular scattered aggregate that is part of it by virtue of some ratio of masses of the two or the counts of the grains of the two or volume occupied by the larger material entity."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003402 a rdfs:Class ;
  rdfs:label "Illumina MouseRef-8 v2.0 beadchip" ;
  rdfs:comment "An Illumina BeadChip which employs direct-hybridization assay, for whole-genome expression profiling in the mouse.This Beadchip contains 8 microarrays, featuring more than 25,000 probes per array, derived from the NCBI RefSeq database and supplemented with MEEBO and RIKEN FANTOM2 content."@en ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:PR_000016801 a rdfs:Class ;
  rdfs:label "transthyretin" ;
  rdfs:comment "A protein that is a translation product of the human TTR gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0001834 a rdfs:Class ;
  rdfs:label "drawing a conclusion" ;
  rdfs:comment "A planned process in which new information is inferred from existing information."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0600059 a rdfs:Class ;
  rdfs:label "DNA transduction"@en ;
  rdfs:comment "a genetic transformation which relies on the use of lysogenic infection to transfer DNA sequences into an organism"@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_1110108 a rdfs:Class ;
  rdfs:label "material to be added" ;
  rdfs:comment "A material entity that is added to another material entity in an “adding a material entity into a target” process."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003536 a rdfs:Class ;
  rdfs:label "observational assessment of individual" ;
  rdfs:comment "A physical examination of an organism through visual assesment."@en ;
  rdfs:subClassOf obo:OBI_0002441 .

obo:GO_0008347 a rdfs:Class ;
  rdfs:label "glial cell migration" ;
  rdfs:comment "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." ;
  rdfs:subClassOf obo:GO_0016477 .

obo:OBI_0000032 a rdfs:Class ;
  rdfs:label "clinical research coordinator role"@en ;
  rdfs:comment "a worker role comprised of handling the administrative duties of a trial or study."@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:OBI_0000196 a rdfs:Class ;
  rdfs:label "role of impartial witness"@en ;
  rdfs:comment "a role which inheres in a Homo sapiens and is realized during a clinical trial - the impartial witness is independent of the trial and cannot be unfairly influenced by people involved with the trial"@en ;
  rdfs:subClassOf obo:OBI_0000016 .

obo:OBI_0002176 a rdfs:Class ;
  rdfs:label "electrophysiology assay" ;
  rdfs:comment "An assay that measures the electrical properties of biological cells or tissues. Typically, this assay will generate measurements of voltage changes or electric current (or other associated variables such as impedence or capacitance)."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0032605 a rdfs:Class ;
  rdfs:label "hepatocyte growth factor production" ;
  rdfs:comment "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003489 a rdfs:Class ;
  rdfs:label "Scrub Typhus Detect IgM ELISA kit" ;
  rdfs:comment "An assay kit that is manufactured by InBios International to use ELISA to test for IgM antibodies for Orientia tsutsugamushi strains Karp, Kato, Gilliam, and TA 716, with a protein microarray that has a 96-well plate and the 56-kDa type-specific antigen."@en ;
  rdfs:subClassOf obo:OBI_0003369 .

obo:OBI_0002571 a rdfs:Class ;
  rdfs:label "polyA-selected RNA sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay to study transcriptomes through the enrichment of polyadenylated transcripts or removal of ribosomal RNA prior to high-throughput sequencing."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_2100029 a rdfs:Class ;
  rdfs:label "triglyceride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of triglyceride"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002036 a rdfs:Class ;
  rdfs:label "array based nucleic acid structure mapping assay" ;
  rdfs:comment "An assay which aims to provide information about the in vivo organization/structure of nucleic acids using chemical or enzymatic probes using a microarray."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_1110174 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific tumor necrosis factor alpha production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects tumor necrosis factor alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001385 , obo:OBI_0001416 .

obo:OBI_2100208 a rdfs:Class ;
  rdfs:label "SPEP protein electrophoresis venous blood beta-globin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of beta-globin in venous blood as part of a SPEP protein electrophoresis order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0002144 a rdfs:Class ;
  rdfs:label "extrachromosomal circular DNA sequencing assay" ;
  rdfs:comment "An assay which aims at identifying the endogenous population of extrachromosomal circular DNA originating from a subset of genomic loci and potentially having profound consequences on the regulatory and coding capabilities of these regions. The assay includes creation of a library out of the circular DNA molecules and subsequent sequencing using parallelized sequencing methods."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0000613 a rdfs:Class ;
  rdfs:label "Bruker SPE-NMR platform" ;
  rdfs:comment "A Solid Phase Extraction (SPE) system provides an interface between liquid chromatography (LC) and NMR. For the process of LC-SPE  NMR a chromatographic separation is done and the peaks of interest are trapped on an individual SPE cartridge after the column. The peak selection is done either by UV detection or by evaluation of the on-line registered MS or MSn spectra."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:OBI_0001890 a rdfs:Class ;
  rdfs:label "email address of specimen collector"@en ;
  rdfs:comment "An email address of the person collecting the specimen"@en ;
  rdfs:subClassOf obo:IAO_0000429 .

obo:OBI_0200019 a rdfs:Class ;
  rdfs:label "loess group transformation two-channel"@en ;
  rdfs:comment "A loess group transformation two-channel is a loess group transformation in the special case where the input is the result of an MA transformation applied to intensities from the two channels of a two-channel assay."@en ;
  rdfs:subClassOf obo:OBI_0200024 .

obo:OBI_0002803 a rdfs:Class ;
  rdfs:label "medical glove" ;
  rdfs:comment "A personal protective glove which is disposable and is used during medical examinations and procedures to help prevent cross-contamination between caregivers and patients."@en ;
  rdfs:subClassOf obo:OBI_0002799 .

obo:CHEBI_31642 a rdfs:Class ;
  rdfs:label "gadodiamide hydrate" ;
  rdfs:comment "The hydrate of gadodiamide." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:PR_000003777 a rdfs:Class ;
  rdfs:label "adiponectin" ;
  rdfs:comment "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0002456 a rdfs:Class ;
  rdfs:label "gravidity inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states one or more gravidity statuses of an organism, which, if met, makes the entity suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:UBERON_0009097 a rdfs:Class ;
  rdfs:label "gravid organism" ;
  rdfs:comment "An organism containing a developing embryo, fetus, or unborn offspring within the body." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:PATO_0000383 a rdfs:Class ;
  rdfs:label "female" ;
  rdfs:comment "A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes." ;
  rdfs:subClassOf obo:PATO_0001894 .

obo:OBI_0001862 a rdfs:Class ;
  rdfs:label "reduced representation bisulfite sequencing assay" ;
  rdfs:comment "A bisulfite sequencing assay that identifies genomic methylation patterns using a bisulfite based protocol that enriches CG-rich parts of the genome."@en ;
  rdfs:subClassOf obo:OBI_0000748 .

obo:OBI_0003576 a rdfs:Class ;
  rdfs:label "skin of body microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in a skin of body specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0002948 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based cell cycle state assay" ;
  rdfs:comment "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures associated with particular cell cycle states."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0003226 a rdfs:Class ;
  rdfs:label "total lymphocyte count assay" ;
  rdfs:comment "A lymphocyte assay that measures the number of lymphocytes and large unstained cells in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003024 .

obo:OBI_2100370 a rdfs:Class ;
  rdfs:label "venous blood Ceruloplasmin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of Ceruloplasmin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0001035 a rdfs:Class ;
  rdfs:label "Nuclease S1 structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution deoxyribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using DNAse 1 as reagent and enzymatic probe."@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:OBI_0002521 a rdfs:Class ;
  rdfs:label "renal medulla specimen" ;
  rdfs:comment "A specimen that is derived from renal medulla."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100080 a rdfs:Class ;
  rdfs:label "liver evaluation venous blood bilirubin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin in venous blood as part of a liver evaluation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100018 .

obo:OBI_0003901 a rdfs:Class ;
  rdfs:label "multi-electrode array assay" ;
  rdfs:comment "A multi-unit recording assay using a multi-electrode array (MEA) on the surface of a well on a cell culture plate."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0002188 .

obo:OBI_0001449 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-1 beta production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-1 beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:CL_0000562 a rdfs:Class ;
  rdfs:label "nucleate erythrocyte" ;
  rdfs:comment "An erythrocyte having a nucleus." ;
  rdfs:subClassOf obo:CL_0000232 .

obo:OBI_0001376 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-3 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001406 .

obo:OBI_0600065 a rdfs:Class ;
  rdfs:label "obsolete_defined processes" ;
  rdfs:comment "Place holder class, see editor note"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000566 a rdfs:Class ;
  rdfs:label "NMR instrument" ;
  rdfs:comment "An Instrument which is used to carry out a NMR analysis of some sample."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001519 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring direct binding of a cell-lysate-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that detects direct binding of a cell-lysate-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001579 .

obo:OBI_2100216 a rdfs:Class ;
  rdfs:label "hepatic panel venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a hepatic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_0001599 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring competitive binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that detects loss of binding of a known reference ligand to cell-bound-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001550 .

obo:GO_0008253 a rdfs:Class ;
  rdfs:label "5'-nucleotidase activity" ;
  rdfs:comment "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0302889 a rdfs:Class ;
  rdfs:label "planned irradiation"@en ;
  rdfs:comment "A planned process by which a material entity is exposed to radiative energy, which could be ionizing radiation (such as gamma rays, X-rays, charged particles or neutrons) or non-ionizing radiation (such as UV light or microwaves)"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:GO_0001755 a rdfs:Class ;
  rdfs:label "neural crest cell migration" ;
  rdfs:comment "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." ;
  rdfs:subClassOf obo:GO_0016477 .

obo:OBI_0002550 a rdfs:Class ;
  rdfs:label "sigmoid colon specimen" ;
  rdfs:comment "A specimen that is derived from sigmoid colon."@en ;
  rdfs:subClassOf obo:OBI_0002533 , obo:OBI_0003483 .

obo:OBI_0200149 a rdfs:Class ;
  rdfs:label "unit-variance scaling"@en ;
  rdfs:comment "A unit-variance scaling is a data transformation that divides all measurements of a variable by the standard deviation of that variable."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_1110026 a rdfs:Class ;
  rdfs:label "host of immune response"@en ;
  rdfs:comment "An organism in which an immune response process occurs."@en ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0000810 a rdfs:Class ;
  rdfs:label "informed consent process" ;
  rdfs:comment "A planned process with the objective to inform a person or their legal representative of legally and ethically relevant facts about a process that the person in question is asked to participate in, and which results in a documented decision as to whether the person in question will participate."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003923 a rdfs:Class ;
  rdfs:label "PacBio Sequel series instrument" ;
  rdfs:comment "A DNA sequencer manufactured and/or marketed by Pacific Biosciences and branded with the word Sequel."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0000694 a rdfs:Class ;
  rdfs:label "animal feeding" ;
  rdfs:comment "animal feeding is a process in which animals are provided with food"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000144 a rdfs:Class ;
  rdfs:label "role of independent data monitoring committee"@en ;
  rdfs:comment "a trial monitor role charged recommending whether to continue, modify, or end the trial"@en ;
  rdfs:subClassOf obo:OBI_0000060 .

obo:OBI_0002403 a rdfs:Class ;
  rdfs:label "hormonal birth control current use history" ;
  rdfs:comment "A hormonal birth control use history that indicates an individual is currently a hormonal birth control user."@en ;
  rdfs:subClassOf obo:OBI_0002401 .

obo:OBI_0003305 a rdfs:Class ;
  rdfs:label "single cell Hi-C assay" ;
  rdfs:comment "A Hi-C assay performed on a single cell."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:OBI_0003319 a rdfs:Class ;
  rdfs:label "granzyme B release during T cell degranulation" ;
  rdfs:comment "The release of granzyme B during cytotoxic T cell degranulation."@en ;
  rdfs:subClassOf obo:GO_0071613 .

obo:OBI_0002942 a rdfs:Class ;
  rdfs:label "Shannon trap" ;
  rdfs:comment "An arthropod trap that is made of cloth and netting and is designed to be suspended from above (e.g. from a tree). It is also designed so that the arthropod enters the trap from beneath, being attracted to some bait, and is prevented from escaping upward by the suspended cloth, which allows them to be collected from the upper interior of the trap."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0001413 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-6 production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interleukin-6 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001451 .

obo:OBI_2100042 a rdfs:Class ;
  rdfs:label "rac-lactic acid assay" ;
  rdfs:comment "An assay that measures rac-lactic acid"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003249 a rdfs:Class ;
  rdfs:label "induced sputum assay datum" ;
  rdfs:comment "A data entity that is the specified output of a induced sputum assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0001913 a rdfs:Class ;
  rdfs:label "computation run time"@en ;
  rdfs:comment "computation run time is a time measurement datum which corresponds the time expressed in second, minute, hour necessary for a computer program to complete a process execution, for example genome assembly. It is an important metrics as it indicates the resource occupancy and computer program efficiency."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0001636 a rdfs:Class ;
  rdfs:label "grant"@en ;
  rdfs:comment "A plan specification of organization A to give money to organization B so that B conducts investigations. Organization A has funder role and Organization B has research organization role."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0002813 a rdfs:Class ;
  rdfs:label "medical cap" ;
  rdfs:comment "A personal protective device which is worn on the head that helps prevent transmission of contaminants contained in hair and scalp."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_0002187 a rdfs:Class ;
  rdfs:label "single-unit recording" ;
  rdfs:comment "An extracellular electrophysiology assay where a single microelectrode is placed in close proximity to a single neuron to measure voltage and current changes over time. This is the technicque used by Hubel and Wiesel to measure firing properties of primary visual cortex neurons in the 1950s in their original Nobel-prize winning study. A classic, old technique."@en ;
  rdfs:subClassOf obo:OBI_0000454 , obo:OBI_0001977 .

obo:OBI_0001578 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific vascular endothelial growth factor production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects vascular endothelial growth factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001570 .

obo:OBI_1110160 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-12 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001391 .

obo:OBI_0003799 a rdfs:Class ;
  rdfs:label "analyte detection by flow based bead assay" ;
  rdfs:comment "An analyte assay that uses beads to measure the concentration of an analyte with a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0000920 .

obo:OBI_0002665 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001280 , obo:OBI_0003115 .

obo:OBI_2100060 a rdfs:Class ;
  rdfs:label "automated differential venous blood monocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of monocytes in venous blood as part of a automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003025 , obo:OBI_0003040 .

obo:REO_0000171 a rdfs:Class ;
  rdfs:label "obsolete molecular label role" ;
  rdfs:comment "A reagent role inhering in a molecular entity intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001520 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring half maximal inhibitory concentration [IC50] to determine competitive binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures half maximal inhibitory concentration (IC50) to detect the loss of binding of a known reference ligand to cell-bound-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001992 .

obo:OBI_0002445 a rdfs:Class ;
  rdfs:label "transcription start site mapping by primer extension assay" ;
  rdfs:comment "A transcription profiling assay in which the transcription start site for a gene is determined by identifying the 5' end of mRNA. A radio-labeled primer is annealed to a complementary mRNA sequence near the 3' end, then cDNA is synthesized until the 5' end is reached."@en ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_0003883 a rdfs:Class ;
  rdfs:label "multiphoton microscope" ;
  rdfs:comment "A microscope that uses simultaneous absorption of multiple photons to excite fluorescent molecules."@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:OBI_0200133 a rdfs:Class ;
  rdfs:label "node out-degree calculation"@en ;
  rdfs:comment "A node quality calculation in which an input data set describing object nodes and directional relationship edges between object nodes is used to enumerate the number of unique relationships pointing out of an individual object node."@en ;
  rdfs:subClassOf obo:OBI_0200129 .

obo:NCBITaxon_32523 a rdfs:Class ;
  rdfs:label "Tetrapoda" ;
  rdfs:subClassOf obo:NCBITaxon_117571 .

obo:CHEBI_35143 a rdfs:Class ;
  rdfs:label "hemoglobin" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:CHEBI_17709 a rdfs:Class ;
  rdfs:label "5'-adenylyl sulfate" ;
  rdfs:comment "An adenosine 5'-phosphate having a sulfo group attached to one the phosphate OH groups." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003479 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An in vivo assay measuring a B cell epitope specific protection from other challenge after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0002638 .

obo:OBI_0003645 a rdfs:Class ;
  rdfs:label "antibody purification of H2-IAd protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAd protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003642 , obo:OBI_0003643 .

obo:OBI_0003758 a rdfs:Class ;
  rdfs:label "cell death assay using caspase abundance to detect apoptosis" ;
  rdfs:comment "A cell death assay that uses fluorescence imaging-based detection of caspases involved in apoptosis"@en ;
  rdfs:subClassOf obo:OBI_0003759 .

obo:OBI_0003507 a rdfs:Class ;
  rdfs:label "nose to finger assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to touch their own nose and then touch an examiners finger in front of them and then touch their own nose once more."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:GO_0019835 a rdfs:Class ;
  rdfs:label "cytolysis" ;
  rdfs:comment "The rupture of cell membranes and the loss of cytoplasm." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0002773 a rdfs:Class ;
  rdfs:label "single-value binding of antibody with reporter to antigen assay" ;
  rdfs:comment "An assay that detects the linking of antigens and antibodies via special signaling mechanisms, such as EIA, ELISA, chemiluminescence, etc. that produces one measure (quantitative or qualitative) of the analyte of interest"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003381 a rdfs:Class ;
  rdfs:label "placental blood microbiology assay" ;
  rdfs:comment "A blood microbiology assay that detects microorganisms in a placental blood specimen."@en ;
  rdfs:subClassOf obo:OBI_0002649 .

obo:OBI_0001234 a rdfs:Class ;
  rdfs:label "epigenetic modification identification objective"@en ;
  rdfs:comment "A molecular feature identification objective that aims to detect epigenetic modifications, such as DNA methylation, histone modifications."@en ;
  rdfs:subClassOf obo:OBI_0000131 .

obo:GO_0007009 a rdfs:Class ;
  rdfs:label "plasma membrane organization" ;
  rdfs:comment "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." ;
  rdfs:subClassOf obo:GO_0009987 .

<http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> a rdfs:Class ;
  rdfs:label "Obsolete Class" .

obo:OBI_0001089 a rdfs:Class ;
  rdfs:label "microhardness tester" ;
  rdfs:comment "A hardness testing device that is used in light-optical microscopes."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:COB_0000056 a rdfs:Class ;
  rdfs:label "obsolete immaterial anatomical entity" .

obo:OBI_0001495 a rdfs:Class ;
  rdfs:label "in vivo assay measuring epitope specific T cell helper activity" ;
  rdfs:comment "A T cell epitope dependent biological activity assay that detects the ability of epitope specific helper T cells to enhance either B cell or T cell adaptive immune response function."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001484 .

obo:OBI_0000044 a rdfs:Class ;
  rdfs:label "physical document"@en ;
  rdfs:comment "A physical document is an object serving as a record of information by means of symbolic marks."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:PR_000036824 a rdfs:Class ;
  rdfs:label "NS1" ;
  rdfs:comment "A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:NCBITaxon_44689 a rdfs:Class ;
  rdfs:label "Dictyostelium discoideum" ;
  rdfs:subClassOf obo:NCBITaxon_2759 .

obo:CL_0000542 a rdfs:Class ;
  rdfs:label "lymphocyte" ;
  rdfs:comment "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." ;
  rdfs:subClassOf obo:CL_0000842 .

obo:OBI_2100364 a rdfs:Class ;
  rdfs:label "venous blood beta hydroxybutryic acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of beta hydroxybutryic acid in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100051 .

obo:OBI_0001441 a rdfs:Class ;
  rdfs:label "proteomic profiling by array design" ;
  rdfs:comment "A study design in which proteins in a sample are detected, quantified or otherwise analysed, through an array-based technology."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002965 a rdfs:Class ;
  rdfs:label "landmark transcript profiling assay" ;
  rdfs:comment "A type of transcription profiling assay in which a set of landmark transcripts that have been determined to provide a comprehensive profile of cell activity, plus numerous steady-state controls, are assayed via ligation-mediated amplification followed by capture on fluorescently labeled microspheres followed by detection of fluorescence."@en ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:CHEBI_37333 a rdfs:Class ;
  rdfs:label "gadodiamide" ;
  rdfs:comment "A non-ionic gadolinium chelate having a macrocyclic triamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI)." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0200077 a rdfs:Class ;
  rdfs:label "gating"@en ;
  rdfs:comment "Gating is a property-based vector selection with the objective of partitioning a data vector set into vector subsets based on dimension values of individual vectors (events), in which vectors represent individual physical particles (often cells) of a sample and dimension values represent light intensity qualities as measured by flow cytometry."@en ;
  rdfs:subClassOf obo:OBI_0200171 , obo:OBI_0200182 .

obo:OBI_0003239 a rdfs:Class ;
  rdfs:label "saliva assay" ;
  rdfs:comment "An assay that has a saliva specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:CHEBI_37987 a rdfs:Class ;
  rdfs:label "Cy3 dye" ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:OBI_0001531 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring half life to determine direct binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures half life to detect the direct binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001990 .

obo:OBI_0000393 a rdfs:Class ;
  rdfs:label "signal conversion function"@en ;
  rdfs:comment "A signal conversion function is an information processor function which transforms a signal into another type of signal. For example an analog-to-digital_converter, Ac/Ac converter, a synapse converts electrical action potentials into an intermediate chemical signal. The post synapse converts it back into an electric one passed on to the axon."@en ;
  rdfs:subClassOf obo:OBI_0000392 .

obo:OBI_0002900 a rdfs:Class ;
  rdfs:label "ultraviolet light source" ;
  rdfs:comment "A light source that provides ultraviolet (UV) light for use in a distant area using a delivery system."@en ;
  rdfs:subClassOf obo:OBI_0400065 .

obo:OBI_0003267 a rdfs:Class ;
  rdfs:label "eukaryota in urine datum" ;
  rdfs:comment "A urine microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003248 .

obo:OBI_0400171 a rdfs:Class ;
  rdfs:label "animal cage" ;
  rdfs:comment "A processed material which has the function to define a bounded habitat which is amenable to keeping animals."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0200025 a rdfs:Class ;
  rdfs:label "loess scale group transformation"@en ;
  rdfs:comment "A loess scale group transformation is a data transformation consisting in the application of a scale adjustment following a loess group transformation, to render the group variances for the second variable (y) similar.  Has objective scaling."@en ;
  rdfs:subClassOf obo:OBI_0200185 .

obo:OBI_0002593 a rdfs:Class ;
  rdfs:label "functional association identification design" ;
  rdfs:comment "A molecular interaction identification design that investigates a relationship that is the result of intermediate steps between two or more molecules that are not necessarily in direct contact with each other."@en ;
  rdfs:subClassOf obo:OBI_0002590 .

obo:OBI_0002058 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific oncostatin M production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects oncostatin M production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0302903 a rdfs:Class ;
  rdfs:label "nucleic acid hybridization"@en ;
  rdfs:comment "a planned process by which totally or partially complementary, single-stranded nucleic acids are  combined into a single molecule called heteroduplex or homoduplex to an extent depending on the amount of complementarity."@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:CHEBI_472552 a rdfs:Class ;
  rdfs:label "5-bromo-2'-deoxyuridine" ;
  rdfs:comment "A pyrimidine 2'-deoxyribonucleoside compound having 5-bromouracil as the nucleobase." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003518 a rdfs:Class ;
  rdfs:label "limits of stability assessment" ;
  rdfs:comment "The functional assessment of an individual's ability to maintain balance, posture or upright stability."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0000834 a rdfs:Class ;
  rdfs:label "high molecular weight DNA extract" ;
  rdfs:comment "The output of an extraction process in which DNA molecules above a molecular weight cutoff are purified in order to exclude DNA from organellas."@en ;
  rdfs:subClassOf obo:OBI_0001051 .

obo:OBI_0400073 a rdfs:Class ;
  rdfs:label "metal vapor laser" ;
  rdfs:comment "A metal vapor laser is a gas laser in which the lasing medium is metal vapor. A metal vapor laser can by used to irradiate cells in a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400047 .

obo:IAO_0000311 a rdfs:Class ;
  rdfs:label "publication"@en ;
  rdfs:comment "A document that is the output of a publishing process."@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0000707 a rdfs:Class ;
  rdfs:label "decision tree building data transformation"@en ;
  rdfs:comment "A decision tree building data transformation is a data transformation that has objective decision tree induction."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0002374 a rdfs:Class ;
  rdfs:label "brother clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male sibling."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0003617 a rdfs:Class ;
  rdfs:label "antibody purification of human MHC class I protein complex" ;
  rdfs:comment "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class I protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003616 , obo:OBI_0003635 .

obo:OBI_0001841 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-1 beta production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-1 beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001449 .

obo:OBI_0001632 a rdfs:Class ;
  rdfs:label "immuno staining assay" ;
  rdfs:comment "A assay detecting a molecular label assay in which the label is attached to an antibody so that substances are marked based on the antibody's binding specificity."@en ;
  rdfs:subClassOf obo:OBI_0600017 .

obo:OBI_1200000 a rdfs:Class ;
  rdfs:label "FFPE specimen" ;
  rdfs:comment "A specimen that has been fixed in formalin and embedded in paraffin."@en ;
  rdfs:subClassOf obo:OBI_0000950 .

obo:PATO_0000140 a rdfs:Class ;
  rdfs:label "position" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0200004 a rdfs:Class ;
  rdfs:label "log-log curve fitting"@en ;
  rdfs:comment "A log-log curve fitting is a curve fitting where first a logarithmic transformation is applied both to the x and the y coordinates of the input data points (x_1, y_1), (x_2, y_2), ..., (x_n, y_n), and then coefficients a and b are determined to optimize the fit of log(y)=a+b*log(x) to these input data points."@en ;
  rdfs:subClassOf obo:OBI_0200072 .

obo:OBI_0001406 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-3 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002999 a rdfs:Class ;
  rdfs:label "gravid female arthropod specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process that has the objective of collecting gravid female arthropods."@en ;
  rdfs:subClassOf obo:OBI_0002913 .

obo:OBI_0000469 a rdfs:Class ;
  rdfs:label "solvent mixer" ;
  rdfs:comment "A liquid chromatography device that mixes different solvents, e.g. under high pressure and in differrent volumes ranging from 5 ml to 5 L capacity. Powerful magnetic mixers provide vigorous agitation required for high pressure reaction chemistry."@en ;
  rdfs:subClassOf obo:OBI_0000485 .

obo:OBI_0200201 a rdfs:Class ;
  rdfs:label "ANOVA" ;
  rdfs:comment "A statistical hypothesis test in which the means of several groups are all equal."@en ;
  rdfs:subClassOf obo:OBI_0000673 .

obo:OBI_0000041 a rdfs:Class ;
  rdfs:label "pump valve switch" ;
  rdfs:comment "A pump valve switch is a cardinal part of a liquid chromatography instrument that controls the flow."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003018 a rdfs:Class ;
  rdfs:label "hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_2100201 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood metamyelocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of metamyelocytes in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003017 , obo:OBI_0003040 .

obo:OBI_0002650 a rdfs:Class ;
  rdfs:label "biopsy" ;
  rdfs:comment "A specimen collection that obtains a sample of tissue or cell from a living multicellular organism body for diagnostic purposes by means intended to be minimally invasive."@en ;
  rdfs:subClassOf obo:OBI_0600005 .

obo:OBI_0000089 a rdfs:Class ;
  rdfs:label "role of regulator of chemical manufacturer"@en ;
  rdfs:comment "a regulator involved with making and enforcing legislation and governmental orders relevant to chemical manufacture"@en ;
  rdfs:subClassOf obo:OBI_0000014 .

obo:OBI_0003073 a rdfs:Class ;
  rdfs:label "organismal body temperature measurement datum" ;
  rdfs:comment "A temperature measurement datum that is about an organism."@en ;
  rdfs:subClassOf obo:OBI_0003079 .

obo:OBI_0003696 a rdfs:Class ;
  rdfs:label "animal investigation"@en ;
  rdfs:comment "An investigation that has non-human animals as its subjects."@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_0000404 a rdfs:Class ;
  rdfs:label "gel dryer" ;
  rdfs:comment "A gel dryer is a device which has the function to contain and to control the contained environment to facilitate the drying of gels"@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0002165 a rdfs:Class ;
  rdfs:label "protein localization assay" ;
  rdfs:comment "An assay that determines the specific location of a protein. Subcellular localization is distinguished from tissue-based localization based on the type of microscopy applied."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:CHEBI_39123 a rdfs:Class ;
  rdfs:label "calcium cation" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_1110052 a rdfs:Class ;
  rdfs:label "cultured CD4-/CD8- T cell population"@en ;
  rdfs:comment "A T cell population characterized by not expressing the CD4 nor the CD8 molecule on its surface."@en ;
  rdfs:subClassOf obo:OBI_0001875 , obo:OBI_1110050 , obo:OBI_1110051 .

obo:PR_000001018 a rdfs:Class ;
  rdfs:label "CD3 subunit with immunoglobulin domain" ;
  rdfs:comment "A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0600054 a rdfs:Class ;
  rdfs:label "selection by survival"@en ;
  rdfs:comment "the use of environmental conditions to select for the organism or cells that have a certain trait"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:PATO_0001740 a rdfs:Class ;
  rdfs:label "activity (of a radionuclide)" ;
  rdfs:comment "A radiation quality inhering in a radioactive substance by virtue of its transformation (disintegration) rate." ;
  rdfs:subClassOf obo:PATO_0002198 .

obo:OBI_1110161 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-1 beta production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-1 beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001449 .

obo:OBI_2100183 a rdfs:Class ;
  rdfs:label "vented blood gas arterial blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a vented blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0002005 a rdfs:Class ;
  rdfs:label "Methylation 27K BeadChip" ;
  rdfs:comment "A methylation BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array interrogates ~ 27,000 CpG sites per sample at single-nucleotide resolution."@en ;
  rdfs:subClassOf obo:OBI_0001870 .

obo:OBI_0003278 a rdfs:Class ;
  rdfs:label "bacteria in pleural fluid datum" ;
  rdfs:comment "A pleural fluid microbiology datum that is about bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003258 .

obo:OBI_2100020 a rdfs:Class ;
  rdfs:label "glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000844 a rdfs:Class ;
  rdfs:label "obsolete hospital" ;
  rdfs:comment "A medical organization at which sick or injured people are given clinical care"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:GO_0003094 a rdfs:Class ;
  rdfs:label "glomerular filtration" ;
  rdfs:comment "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." ;
  rdfs:subClassOf obo:GO_0003014 .

obo:OBI_0001709 a rdfs:Class ;
  rdfs:label "assay measuring a binding constant of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope recognition assay that quantitavely characterizes the binding of an antibody / BCR with a ligand by determining a binding constant."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003146 .

obo:OBI_0003021 a rdfs:Class ;
  rdfs:label "basophil assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of basophils"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002160 a rdfs:Class ;
  rdfs:label "multiplexed indexed T7 ChIP-seq assay" ;
  rdfs:comment "A ChIP-seq assay which leverages T7 promoter amplification to allow low sample input and chromatin barcoding and pool-and-split multiplexing for high-throughput, quantitative profiling of chromatin states."@en ;
  rdfs:subClassOf obo:OBI_0000716 .

obo:OBI_0000788 a rdfs:Class ;
  rdfs:label "fluorescently labeled MHC multimer" ;
  rdfs:comment "A complex of two or more linked MHC molecules including a fluorescent label that can be loaded with a ligand, and is used in flow cytometry assay to bind to T cell receptors of T cells specific for the ligand"@en ;
  rdfs:subClassOf obo:COB_0000026 , obo:OBI_0001936 .

obo:OBI_0000496 a rdfs:Class ;
  rdfs:label "capillary column" ;
  rdfs:comment "A capillary column is a thin tube with a small inner diameter, usually around 0.5 mm."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CHEBI_33321 a rdfs:Class ;
  rdfs:label "rare earth metal atom" ;
  rdfs:subClassOf obo:COB_0000011 .

obo:OBI_0001379 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001414 , obo:OBI_0003115 .

obo:OBI_0000411 a rdfs:Class ;
  rdfs:label "cloning vector role"@en ;
  rdfs:comment "A material to be added role played by a small, self-replicating DNA or RNA molecule - usually a plasmid or chromosome - and realized in a process whereby foreign DNA or RNA is inserted into the vector during the process of cloning."@en ;
  rdfs:subClassOf obo:OBI_0000319 .

obo:OBI_0003648 a rdfs:Class ;
  rdfs:label "liquid chromatrography mass spectrometry analysis" ;
  rdfs:subClassOf obo:OBI_0200085 .

obo:OBI_2100267 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003232 , obo:OBI_2100020 .

obo:OBI_0002053 a rdfs:Class ;
  rdfs:label "microarray assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A microarray assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001703 , obo:OBI_0001985 .

obo:OBI_0003832 a rdfs:Class ;
  rdfs:label "hemolysis assay" ;
  rdfs:comment "A hematology assay that measures the fragility of red blood cells by observing spillage of hemoglobin from burst cells."@en ;
  rdfs:subClassOf obo:OBI_0000630 , obo:OBI_0003040 .

obo:OBI_0001917 a rdfs:Class ;
  rdfs:label "chromosome conformation identification objective"@en ;
  rdfs:comment "A molecular feature identification objective that aims to determine spatial organization of chromatin."@en ;
  rdfs:subClassOf obo:OBI_0000131 .

obo:MRO_0001355 a rdfs:Class ;
  rdfs:label "MHC class I protein complex" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:OBI_2100280 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood temperature assay" ;
  rdfs:comment "An assay that measures temperature in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_2100188 a rdfs:Class ;
  rdfs:label "arterial blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0000379 a rdfs:Class ;
  rdfs:label "mechanical function"@en ;
  rdfs:comment "A mechanical function is a function that is realised via mechanical work (through an certain amount of energy transferred by some force)."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0003432 a rdfs:Class ;
  rdfs:label "isocitrate dehydrogenase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of isocitrate dehydrogenase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0003392 a rdfs:Class ;
  rdfs:label "Affymetrix Mouse Genome 430A 2.0 Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix for gene expression analysis focusing on approximately 14,000 well-characterized genes in the transcribed mouse genome using single-array cartridge. Sequences used in the design of the array were selected from GenBank™, dbEST, and RefSeq. The sequence clusters were created from the UniGene database."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0001265 a rdfs:Class ;
  rdfs:label "FWER adjusted p-value" ;
  rdfs:comment "A quantitative confidence value resulting from a multiple testing error correction method which adjusts the p-value used as input to control for Type I error in the context of multiple pairwise tests"@en ;
  rdfs:subClassOf obo:OBI_0000071 .

obo:OBI_0001490 a rdfs:Class ;
  rdfs:label "cytometric bead array measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects granulocyte macrophage colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001233 , obo:OBI_0003115 .

obo:OBI_0000714 a rdfs:Class ;
  rdfs:label "graph of vertices" ;
  rdfs:comment "A construct that consists of many nodes connected with edges. The edges represent a relationship between the objects represented by the nodes.  A graph can be equivalently represented as a matrix."@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:OBI_0003468 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific survival after pathogen challenge" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from pathogen challenge using survival."@en ;
  rdfs:subClassOf obo:OBI_0003457 , obo:OBI_0003465 .

obo:PATO_0000008 a rdfs:Class ;
  rdfs:label "speed" ;
  rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position." ;
  rdfs:subClassOf obo:PATO_0001906 .

obo:OBI_0000530 a rdfs:Class ;
  rdfs:label "Bruker UltraShield Plus NMR magnet" ;
  rdfs:comment "An NMR magnet of which Brukers claims it is the latest and most advanced self-shielding NMR magnet technology ever developed. These magnets are the ultimate advancement in high performance, actively-shielded NMR solutions. They offer unprecedented shielding performance whilst ensuring no compromise in system homogeneity, stability or cryogenic specifications."@en ;
  rdfs:subClassOf obo:OBI_0000597 .

obo:CHEBI_22868 a rdfs:Class ;
  rdfs:label "bile salt" ;
  rdfs:comment "A sodium salt of the conjugate of any bile acid with either glycine or taurine." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002720 a rdfs:Class ;
  rdfs:label "insecticide resistance by primer introduced restriction analysis PCR assay" ;
  rdfs:comment "An insecticide resistance by monitoring known mutations assay that detects Single Nucleotide Polymorphisms (SNPs) using PCR technique and mismatched primers that is close to the mutation of interest and digested the PCR productions using restriction enzymes."@en ;
  rdfs:subClassOf obo:OBI_0002692 , obo:OBI_0002696 .

obo:OBI_0200114 a rdfs:Class ;
  rdfs:label "euclidean distance calculation"@en ;
  rdfs:comment "An euclidean distance calculation is a similarity calculation that attaches to each pair of real number vectors of the same dimension n the square root of the sum of the square differences between corresponding components. The smaller this number, the more similar the two vectors are considered."@en ;
  rdfs:subClassOf obo:OBI_0200113 .

obo:OBI_0003327 a rdfs:Class ;
  rdfs:label "image data set" ;
  rdfs:comment "A data set that is comprised of multidimensional structured measurements and metadata required for a morphological representation of an entity. An image data set can be the source from which an image (such as a 2D image using pixels or a 3D image using voxels) is produced."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0000686 a rdfs:Class ;
  rdfs:label "material combination objective" ;
  rdfs:comment "is an objective to obtain an output material that contains several input materials."@en ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:OBI_0000980 a rdfs:Class ;
  rdfs:label "obsolete_protocol service provider role" ;
  rdfs:comment "a service provider role which is realized by a servicer provider organization performing a protocol execution"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002110 a rdfs:Class ;
  rdfs:label "digital object identifier"@en ;
  rdfs:comment "A centrally registered identifier symbol used to uniquely identify objects given by International DOI Foundation. The DOI system is particularly used for electronic documents such as journal articles."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0000151 a rdfs:Class ;
  rdfs:label "filter paper" ;
  rdfs:comment "A device manufacture with the intent to provide a porous unsized paper used for filtering."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0302900 a rdfs:Class ;
  rdfs:label "group randomization"@en ;
  rdfs:comment "A group assignment which relies on chance to assign materials to a group of materials in order to avoid bias in experimental set up."@en ;
  rdfs:subClassOf obo:OBI_0600015 .

obo:OBI_0001802 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-3 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001406 , obo:OBI_0600031 .

obo:HP_0002664 a rdfs:Class ;
  rdfs:label "Neoplasm" ;
  rdfs:comment "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor)." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_0001928 a rdfs:Class ;
  rdfs:label "selection"@en ;
  rdfs:comment "A planned process with the objective to create a group of entities by applying a predefined criteria to a larger group of entities."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:CLO_0000019 a rdfs:Class ;
  rdfs:label "immortal cell line cell" ;
  rdfs:comment "A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line." ;
  rdfs:subClassOf obo:CLO_0000001 .

obo:GO_0097088 a rdfs:Class ;
  rdfs:label "interleukin-17F production" ;
  rdfs:comment "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032620 .

obo:OBI_0001245 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific perforin release" ;
  rdfs:comment "A detection of specific nucleic acids with complementary probes assay that detects epitope specific perforin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001497 .

obo:OBI_0200107 a rdfs:Class ;
  rdfs:label "partial least square discriminant analysis"@en ;
  rdfs:comment "PLS Discriminant Analysis (PLS-DA) is a discriminant analysis performed in order to sharpen the separation between groups of observations, by hopefully rotating PCA (Principal Components Analysis) components such that a maximum separation among classes is obtained, and to understand which variables carry the class separating information."@en ;
  rdfs:subClassOf obo:OBI_0200106 .

obo:OBI_2100199 a rdfs:Class ;
  rdfs:label "trough venous blood tobramycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of tobramycin in venous blood as part of a trough order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100045 .

obo:GO_0003014 a rdfs:Class ;
  rdfs:label "renal system process" ;
  rdfs:comment "An organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003155 a rdfs:Class ;
  rdfs:label "globulin concentration assay" ;
  rdfs:comment "A globulin assay that measures the concentration of globulin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003015 .

obo:OBI_0002064 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific granzyme A release by T cells" ;
  rdfs:comment "A detection of specific nucleic acids with complementary probes assay that detects epitope specific granzyme A release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001809 .

obo:IAO_0000144 a rdfs:Class ;
  rdfs:label "conclusion textual entity"@en ;
  rdfs:comment "A textual entity that expresses the results of reasoning about a problem, for instance as typically found towards the end of scientific papers."@en ;
  rdfs:subClassOf obo:IAO_0000300 , obo:OBI_0001909 .

obo:OBI_0001813 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-27 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-27 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001198 , obo:OBI_0600031 .

obo:OBI_0003428 a rdfs:Class ;
  rdfs:label "cholinesterase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of cholinesterase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:IAO_8000016 a rdfs:Class ;
  rdfs:label "taxonomic bridge ontology module"@en ;
  rdfs:subClassOf obo:IAO_8000004 .

obo:OBI_0000485 a rdfs:Class ;
  rdfs:label "chromatography instrument" ;
  rdfs:comment "Any instrument that is used to carry out a chromatography experiment."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0002010 a rdfs:Class ;
  rdfs:label "Human 3x720K Whole Genome CGH Tiling Array" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 3x720,000 features."@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_1110051 a rdfs:Class ;
  rdfs:label "cultured CD8- T cell population"@en ;
  rdfs:comment "A T cell population characterized by not expressing the CD8 molecule on its surface."@en ;
  rdfs:subClassOf obo:OBI_0001875 .

obo:CHEBI_59055 a rdfs:Class ;
  rdfs:label "(S)-1-(4-bromoacetamidobenzyl)EDTA" ;
  rdfs:comment "A tetracarboxylic acid consisting of ethylenediaminetetraacetic acid having a 4-bromoacetamidobenzyl group at the C1-position and (<i>S</i>)-configuration." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000689 a rdfs:Class ;
  rdfs:label "454 Genome Sequence 20" ;
  rdfs:comment "is a DNA sequencer first manufactured by 454 Life Science Corporation in 2005, and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are controlled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0200122 a rdfs:Class ;
  rdfs:label "interquartile-range calculation"@en ;
  rdfs:comment "The interquartile range is a descriptive statistics calculation defined as the difference between the 0.75 quantile and the 0.25 quantile for a set of data."@en ;
  rdfs:subClassOf obo:OBI_0200086 , obo:OBI_0200184 .

obo:OBI_0002735 a rdfs:Class ;
  rdfs:label "organism detection by size assay" ;
  rdfs:comment "An organism detection assay that is based on the size of organism."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_2100057 a rdfs:Class ;
  rdfs:label "automated differential venous blood neutrophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of neutrophils in venous blood as part of a automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003022 , obo:OBI_0003040 .

obo:OBI_0003800 a rdfs:Class ;
  rdfs:label "bacterial lipopolysaccharide"@en ;
  rdfs:comment "A molecule that is a component of the outermost membrane of the cell envelope of gram-negative bacteria and which consists of three parts: an outer core polysaccharide termed the O-antigen, an inner core oligosaccharide, and Lipid A, all covalently linked."@en ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002774 a rdfs:Class ;
  rdfs:label "platelet-poor plasma specimen" ;
  rdfs:comment "A blood plasma specimen that is the output of some platelet-poor plasma preparation and is the portion of plasma that contains fewer than 10,000 platelets per microliter."@en ;
  rdfs:subClassOf obo:OBI_0100016 .

obo:CHEBI_16919 a rdfs:Class ;
  rdfs:label "creatine" ;
  rdfs:comment "A glycine derivative having methyl and amidino groups attached to the nitrogen." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0200092 a rdfs:Class ;
  rdfs:label "Westfall and Young family wise error rate correction"@en ;
  rdfs:comment "Is a data transformation process in which the Westfall and Young method is applied with the aim of controlling for multiple testing"@en ;
  rdfs:subClassOf obo:OBI_0200073 .

obo:OBI_0002520 a rdfs:Class ;
  rdfs:label "heart specimen" ;
  rdfs:comment "A specimen that is derived from heart."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100017 a rdfs:Class ;
  rdfs:label "alkaline phosphatase (human) assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alkaline phosphatase (human)"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:OBI_0001958 a rdfs:Class ;
  rdfs:label "systematic review study design" ;
  rdfs:comment "A study design for identifying in the literature prior studies of a pre-determined phenomenon or set of related phenomena according to certain criteria, extracting findings from these studies, and summarizing these findings and/or attempting to draw new conclusions from them which were not justified by any of the individual, prior studies. Many systematic reviews also assess the quality of the studies so reviewed."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0600040 a rdfs:Class ;
  rdfs:label "synthesis"@en ;
  rdfs:comment "the construction of a biomaterial from simpler biomaterials"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:MRO_0001167 a rdfs:Class ;
  rdfs:label "HLA-DP protein complex" ;
  rdfs:subClassOf obo:MRO_0001455 .

obo:SO_0001410 a rdfs:Class ;
  rdfs:label "experimental_feature" ;
  rdfs:comment "A region which is the result of some arbitrary experimental procedure. The procedure may be carried out with biological material or inside a computer." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:CHEBI_24621 a rdfs:Class ;
  rdfs:label "hormone" ;
  rdfs:comment "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2100278 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0001625 a rdfs:Class ;
  rdfs:label "sequence annotation algorithm"@en ;
  rdfs:comment "An algorithm used to identify sequence features (e.g. protein coding regions) in the assembled contig sequence.  This may also include a description of any manual curation that may have generated or validated the annotation."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0002768 a rdfs:Class ;
  rdfs:label "whole virome sequencing assay" ;
  rdfs:comment "A whole metagenome sequencing assay that intends to provide information on multiple genome sequences from different viruses present in the same input sample."@en ;
  rdfs:subClassOf obo:OBI_0002623 .

obo:OBI_0000635 a rdfs:Class ;
  rdfs:label "JEOL CapNMR probe" ;
  rdfs:comment "The JEOL ECA and ECX NMR spectrometers now support the MRM/Protasis CapNMR Probe for well plate-based and microvial-based NMR analysis. The CapNMR probe is available at proton frequencies ranging from 300 MHz to 800 MHz in both indirect configurations (e.g. 1H{13C} and 1H {31P}) and also in triple resonance configurations (e.g. 1H{13C, 15N}, 1H{31P, 15N}). Both employ a high-strength z-directed field gradient. The flowprobes come with the choice of two flowcell volumes: a 5 μl flowcell with an NMR active volume of 2.5 μl, and a 10 μl flowcell with an NMR active volume of 5 μl. The fluidic connections are 75 μm i.d. and 1/32 o.d. FEP Teflon with hastelloy unions for exceptional solvent compatibility."@en ;
  rdfs:subClassOf obo:OBI_0000529 .

obo:OBI_2100096 a rdfs:Class ;
  rdfs:label "venous blood ferritin assay" ;
  rdfs:comment "An assay that measures ferritin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003009 , obo:OBI_0003040 .

obo:UBERON_8470000 a rdfs:Class ;
  rdfs:label "placental blood" ;
  rdfs:comment "Blood located in the placenta." ;
  rdfs:subClassOf obo:UBERON_0000178 .

obo:OBI_0003792 a rdfs:Class ;
  rdfs:label "bacterial flagellin detection in feces assay" ;
  rdfs:comment "An analyte assay measuring bacterial flagellin in a feces sample."@en ;
  rdfs:subClassOf obo:OBI_0003237 , obo:OBI_2100023 .

obo:NCBITaxon_9989 a rdfs:Class ;
  rdfs:label "Rodentia" ;
  rdfs:subClassOf obo:NCBITaxon_314146 .

obo:OBI_0000018 a rdfs:Class ;
  rdfs:label "material supplier role"@en ;
  rdfs:comment "a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation."@en ;
  rdfs:subClassOf obo:OBI_0000947 .

obo:OBI_0001665 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring binding off rate [koff] to determine direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures binding off rate [koff] to detect direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001993 .

obo:OBI_2100309 a rdfs:Class ;
  rdfs:label "venous blood valproic acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of valproic acid in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_0001784 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects monocyte chemotactic protein-1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001465 , obo:OBI_0600031 .

obo:OBI_1110181 a rdfs:Class ;
  rdfs:label "BrdU assay measuring epitope specific proliferation of T cells" ;
  rdfs:comment "A BrdU incorporation assay that detects T cell epitope specific proliferation in vitro."@en ;
  rdfs:subClassOf obo:OBI_0000664 , obo:OBI_0002071 .

obo:OBI_0002683 a rdfs:Class ;
  rdfs:label "short interspersed nuclear elements polymerase chain reaction" ;
  rdfs:comment "A polymerase chain reaction that amplifies short interspersed nuclear elements (SINEs)."@en ;
  rdfs:subClassOf obo:OBI_0000415 .

obo:UBERON_0001323 a rdfs:Class ;
  rdfs:label "tibial nerve" ;
  rdfs:comment "The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_2100194 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0001997 a rdfs:Class ;
  rdfs:label "hydrogen/deuterium exchange footprinting assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A hydrogen/deuterium exchange footprinting assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001976 , obo:OBI_0002449 .

obo:OBI_1110030 a rdfs:Class ;
  rdfs:label "experimental infection of cell culture"@en ;
  rdfs:comment "is the administration of an infectious agent to a cell culture with the objective to have the agent colonize and replicate in culture"@en ;
  rdfs:subClassOf obo:OBI_0600000 .

obo:OBI_2100262 a rdfs:Class ;
  rdfs:label "24 hour urine protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in urine as part of a 24 hour order"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100023 .

obo:CHEBI_33696 a rdfs:Class ;
  rdfs:label "nucleic acid" ;
  rdfs:comment "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), <small>D</small>-ribose or 2-deoxy-<small>D</small>-ribose and phosphoric acid." ;
  rdfs:subClassOf obo:CHEBI_33839 .

obo:IAO_8000001 a rdfs:Class ;
  rdfs:label "base ontology module"@en ;
  rdfs:comment "An ontology module that comprises only of asserted axioms local to the ontology, excludes import directives, and excludes axioms or declarations from external ontologies."@en ;
  rdfs:seeAlso <https://github.com/INCATools/ontology-starter-kit/issues/50> ;
  rdfs:subClassOf obo:IAO_8000000 .

obo:OBI_0003115 a rdfs:Class ;
  rdfs:label "antigen detection by cytometric bead array assay" ;
  rdfs:comment "A cytometric bead array assay in which a series of beads are coated with antibodies specific to antigens of interest. Antigens of interest attach to antibodies on the beads. Fluorescent labeled secondary antibodies are used to detect the antigens of interest."@en ;
  rdfs:subClassOf obo:OBI_0000920 .

obo:OBI_0002385 a rdfs:Class ;
  rdfs:label "diagnosis of infectious disease" ;
  rdfs:comment "A diagnosis that is an assertion that a patient who is the subject of a diagnostic process has an infectious disease."@en ;
  rdfs:subClassOf obo:OGMS_0000073 .

obo:OBI_0000877 a rdfs:Class ;
  rdfs:label "cell line immortalization" ;
  rdfs:comment "an establishing cell line process whereby a mortal cell line is intentionally genetically modified to be capable of indefinite propagation and re-established as a new immortal cell line"@en ;
  rdfs:subClassOf obo:OBI_0001867 .

obo:OBI_0001357 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects granulocyte macrophage colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001233 .

obo:OBI_0003076 a rdfs:Class ;
  rdfs:label "age since birth at time of visit" ;
  rdfs:comment "An age since birth measurement datum at the time of a clinical visit."@en ;
  rdfs:subClassOf obo:OBI_0001169 .

obo:GO_0097278 a rdfs:Class ;
  rdfs:label "complement-dependent cytotoxicity" ;
  rdfs:comment "Cell killing caused by the membrane attack complex formed following complement activation." ;
  rdfs:subClassOf obo:GO_0001906 .

obo:OBI_0400084 a rdfs:Class ;
  rdfs:label "photomultiplier tube" ;
  rdfs:comment "A photomultiplier is a device that is normally in the form of a tube, that uses a photocathode to convert photons into photoelectrons which are then amplified. PMTs are typically used to detect SSC and fluorescent parameters. Cytometers have a PMT for each color they can collect."@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0000967 .

obo:OBI_0001153 a rdfs:Class ;
  rdfs:label "genetic transformation objective"@en ;
  rdfs:comment "a material transformation objective aims to create genetically modified organism or cell"@en ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:OBI_0001908 a rdfs:Class ;
  rdfs:label "testable hypothesis" ;
  rdfs:comment "An information content entity that expresses an assertion that is intended to be tested."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003043 a rdfs:Class ;
  rdfs:label "urine assay" ;
  rdfs:comment "An assay that has a urine specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001772 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-17F production by T cells" ;
  rdfs:comment "An assay of epitope specific interleukin-17 production by T cells that detects interleukin-17F production."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001295 .

obo:OBI_0000119 a rdfs:Class ;
  rdfs:label "number of particles in subset"@en ;
  rdfs:comment "A measurement datum measuring the number of subjects in a defined subset in a flow cytometer instrument. The datum has a qualitative role"@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0000737 a rdfs:Class ;
  rdfs:label "cloning vector" ;
  rdfs:comment "A cloning vector is an engineered material that is used as an input material for a recombinant vector cloning process to carry inserted nucleic acids. It contains an origin of replication for a specific destination host organism, encodes for a selectable gene product and contains a cloning site."@en ;
  rdfs:subClassOf obo:BFO_0000040 , obo:OBI_1110108 .

obo:OBI_0200014 a rdfs:Class ;
  rdfs:label "split-scale transformation"@en ;
  rdfs:comment "A split-scale transformation is a data transformation which is an application of a function f described as follows to a (one dimensional) real number input. f(x)=a*x+b if x=for x>t; where log denotes a logarithmic transformation and a, b, c, d, r, t are real constants, with a, c, d, r, t positive, chosen so that f is continuous with a continuous derivative at the transition point t."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:GO_0048709 a rdfs:Class ;
  rdfs:label "oligodendrocyte differentiation" ;
  rdfs:comment "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." ;
  rdfs:subClassOf obo:GO_0030154 .

obo:OBI_0000512 a rdfs:Class ;
  rdfs:label "isolation of cell population" ;
  rdfs:comment "a process in which a population of cells with certain characteristics is isolated from a larger population"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0001329 a rdfs:Class ;
  rdfs:label "family history design" ;
  rdfs:comment "A study design in which the family history such as traits, characteristics, susceptibility to disease is studied."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002466 a rdfs:Class ;
  rdfs:label "alignment counting algorithm" ;
  rdfs:comment "An algorithm used to assign aligned sequence reads, resulting from a reference genome transcriptome alignment algorithm, to sequence features (e.g. genes or transcripts)."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0001824 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-18 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-18 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001380 .

obo:OBI_0000286 a rdfs:Class ;
  rdfs:label "precipitate"@en ;
  rdfs:comment "a precipitate is a material entity which is output of a precipitation process"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0002746 a rdfs:Class ;
  rdfs:label "induced sputum specimen" ;
  rdfs:comment "A sputum specimen that is collected from an organism following its inhalation of a nebulized salt solution."@en ;
  rdfs:subClassOf obo:OBI_0002508 .

obo:OBI_0001828 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects chemokine (C-C motif) ligand 1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001276 , obo:OBI_0003115 .

obo:OBI_0002937 a rdfs:Class ;
  rdfs:label "outlet window trap" ;
  rdfs:comment "An arthropod trap that is positioned adjacent to a window of a building and is designed to collect arthropods flying out of the building."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0003352 a rdfs:Class ;
  rdfs:label "T2 weighted STIR magnetic resonance image data set" ;
  rdfs:comment "A T2 weighted magnetic resonance image data set collected using a STIR sequence to suppress the signal coming from fat."@en ;
  rdfs:subClassOf obo:OBI_0003348 .

obo:OBI_0000624 a rdfs:Class ;
  rdfs:label "Bruker SampleJet system" ;
  rdfs:comment "Bruker BioSpin introduces the SampleJet, a robot for NMR tube automation. The SampleJet has been consciously designed to meet the growing customer demand for simplicity, versatility and higher throughput in NMR sample tube automation.n  The SampleJet utilizes the modern-day industry standard for sample arrangements-the 96 well plate array. Therefore, the samples may be handled by standard lab automation devices before or after the NMR measurement."@en ;
  rdfs:subClassOf obo:OBI_0000464 .

obo:OBI_0003465 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from pathogen challenge" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from pathogen challenge."@en ;
  rdfs:subClassOf obo:OBI_0001179 , obo:OBI_0001710 .

obo:OBI_0001969 a rdfs:Class ;
  rdfs:label "biodiversity assessment objective"@en ;
  rdfs:comment "biodiversity assessment objective is an objective of a planned process aimed at producing data item whose interpretation should provide insight about variety of biological species found in a biological sample at macroscopic or microscopic level"@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0002763 a rdfs:Class ;
  rdfs:label "16s ribosomal gene sequencing assay" ;
  rdfs:comment "An amplicon sequencing assay in which the amplicon is derived from universal primers used to amplify the 16S ribosomal RNA gene from isolate bacterial genomic DNA or metagenomic DNA from a microbioal community. Resulting sequences are compared to reference 16S sequence databases to identify or classify bacteria present within a given sample."@en ;
  rdfs:subClassOf obo:OBI_0001960 , obo:OBI_0002767 .

obo:OBI_0400036 a rdfs:Class ;
  rdfs:label "FACS Calibur" ;
  rdfs:comment "The FACS Calibur is one of the most popular cytometers in use for research."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0000052 a rdfs:Class ;
  rdfs:label "microarray platform" ;
  rdfs:comment "A microarray platform is a platform that contains the instruments, software and reagents needed to perform a microarray protocol. definition_source: OBI."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_0001668 a rdfs:Class ;
  rdfs:label "split-ubiquitin assay" ;
  rdfs:comment "A binding assay that screens membrane soluble proteins by fusion of two integral membrane proteins (bait and prey) to two different ubiquitin moieties. One moiety is also fused to a transcription factor (TF) that can be cleaved off by ubiquitin specific proteases. Upon bait and prey interaction, Nub and Cub-moieties assemble, reconstituting the split-ubiquitin. The reconstituted split-ubiquitin molecule is recognized by ubiquitin specific proteases, which cleave off the reporter protein, allowing it to induce the transcription of reporter genes."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0001939 a rdfs:Class ;
  rdfs:label "genome coverage" ;
  rdfs:comment "A data item that is the total number of bases in reads, divided by genome size, assumed to be the reference size (for instance of 3.10 Gb for human and 2.73 Gb for mouse) and refers to the percentage of the genome that is contained in the assembly based on size estimates; these are usually based on cytological techniques. Genome coverage of 90–95% is generally considered to be good, as most genomes contain a considerable fraction of repetitive regions that are difficult to sequence. So it is not a cause for concern if the genome coverage of an assembly is a bit less than 100%."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_2100245 a rdfs:Class ;
  rdfs:label "chem16 venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_0600015 a rdfs:Class ;
  rdfs:label "group assignment"@en ;
  rdfs:comment "group assignment is a process which has an organism as specified input and during which a role is assigned"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:SO_0000235 a rdfs:Class ;
  rdfs:label "TF_binding_site" ;
  rdfs:comment "A DNA site where a transcription factor binds." ;
  rdfs:subClassOf obo:SO_0005836 .

obo:OBI_2100031 a rdfs:Class ;
  rdfs:label "cholesterol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of cholesterol"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001036 a rdfs:Class ;
  rdfs:label "specimen fixation function" ;
  rdfs:comment "a function that allows specific identification of individual speciment from one another."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0000629 a rdfs:Class ;
  rdfs:label "Bruker solid magic angle spinning probe" ;
  rdfs:comment "Magic angle spinning, nowadays a routine technique for solids NMR, still offers the capability of innovation. The high mechanical performance of MAS probes in conjunction with efficient rf pulse techniques open new exciting fields in solids NMR of biological samples and in the field of quadrupolar nuclei."@en ;
  rdfs:subClassOf obo:OBI_0000561 .

obo:OBI_1110150 a rdfs:Class ;
  rdfs:label "51 chromium assay measuring epitope specific T cell killing" ;
  rdfs:comment "A chromium release assay that detects the killing of an antigen presenting cell (APC) by a T cell whose TCR recognizes an epitope presented by the APC."@en ;
  rdfs:subClassOf obo:OBI_0002062 , obo:OBI_9999994 .

obo:CHEBI_33839 a rdfs:Class ;
  rdfs:label "macromolecule" ;
  rdfs:comment "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003269 a rdfs:Class ;
  rdfs:label "eukaryota in induced sputum datum" ;
  rdfs:comment "An induced sputum microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003251 .

obo:OBI_0003195 a rdfs:Class ;
  rdfs:label "creatine concentration assay" ;
  rdfs:comment "A creatine assay that measures the concentration of creatine in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003194 .

obo:OBI_0001589 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-17A production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-17A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001773 , obo:OBI_1110178 .

obo:OBI_0000721 a rdfs:Class ;
  rdfs:label "glucose tolerance test" ;
  rdfs:comment "An assay that measures glucose clearance from blood over time by repeated glucose measurement in blood serum or plasma after the administration of a glucose bolus in-vivo. This assay can be used to evaluate the severity of insulin resistance or the efficiency of glucose clearance."@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:IAO_8000012 a rdfs:Class ;
  rdfs:label "species subset ontology module"@en ;
  rdfs:comment "A subset ontology that is crafted to either include or exclude a taxonomic grouping of species."@en ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/Taxon-constraints> ;
  rdfs:subClassOf obo:IAO_8000006 .

obo:OBI_0003086 a rdfs:Class ;
  rdfs:label "laboratory-based population" ;
  rdfs:comment "A population where the collection of individuals is located and maintained in a laboratory, research, or production facility."@en ;
  rdfs:subClassOf obo:OBI_0000181 .

obo:OBI_0400148 a rdfs:Class ;
  rdfs:label "DNA microarray" ;
  rdfs:comment "A DNA-microarray is a microarray that is used as a physical 2D immobilisation matrix for DNA sequences. DNA microarray-bound DNA fragments are used as targets for a hybridising probed sample."@en ;
  rdfs:subClassOf obo:OBI_0400147 .

obo:OBI_0001654 a rdfs:Class ;
  rdfs:label "mass spectrometry assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A mass spectrometry assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000470 , obo:OBI_0001703 .

obo:OBI_0000956 a rdfs:Class ;
  rdfs:label "obsolete_handedness" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001430 a rdfs:Class ;
  rdfs:label "transcription profiling design" ;
  rdfs:comment "A study design that identifies forms and abundance of transcripts in the genome."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0000066 a rdfs:Class ;
  rdfs:label "investigation"@en ;
  rdfs:comment "a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s)."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001058 a rdfs:Class ;
  rdfs:label "microplate reader" ;
  rdfs:comment "A measurement device that detects biological, chemical or physical events of samples in microtiter plates."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0000208 a rdfs:Class ;
  rdfs:label "methodology testing objective"@en ;
  rdfs:comment "Methodology_testing_objective is an objective role carried out by a proposition defining the aim of the study is to examine the effect of using different methodologies."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0003341 a rdfs:Class ;
  rdfs:label "T1 weighted magnetic resonance image data set" ;
  rdfs:comment "An magnetic resonance image acquired using a T1 weighted magnetic resonance image acquisition sequence."@en ;
  rdfs:subClassOf obo:OBI_0003334 .

obo:OBI_0002654 a rdfs:Class ;
  rdfs:label "needle biopsy" ;
  rdfs:comment "A biopsy that uses a hollow needle to extract cells."@en ;
  rdfs:subClassOf obo:OBI_0002650 .

obo:OBI_0002427 a rdfs:Class ;
  rdfs:label "radiation treatment within the recent past exclusion criterion" ;
  rdfs:comment "An exclusion criterion that defines whether radiation was received within a certain timeframe, which when met, makes an individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:CHEBI_81567 a rdfs:Class ;
  rdfs:label "thyroid stimulating hormone" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000249 a rdfs:Class ;
  rdfs:label "technical replicate role"@en ;
  rdfs:comment "technical replicate role is realized when two portions from one evaluant are used in replicate runs of an assay"@en ;
  rdfs:subClassOf obo:OBI_0000220 .

obo:GO_0032612 a rdfs:Class ;
  rdfs:label "interleukin-1 production" ;
  rdfs:comment "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0002564 a rdfs:Class ;
  rdfs:label "histopathology assay" ;
  rdfs:comment "A histological assay that is intended to check for the presence or level of a specific disease."@en ;
  rdfs:subClassOf obo:OBI_0600020 .

obo:OBI_0001525 a rdfs:Class ;
  rdfs:label "PDB file" ;
  rdfs:comment "A 3d structural organization datum capturing the results of X-ray crystallography or NMR experiment that is formatted as specified by the Protein Databank (http://www.wwpdb.org/docs.html). A PDB file can describe the structure of multiple molecules, each of which has a different chain identifier assigned."@en ;
  rdfs:subClassOf obo:OBI_0001155 .

obo:OBI_2100133 a rdfs:Class ;
  rdfs:label "venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0003104 a rdfs:Class ;
  rdfs:label "single cell combinatorial indexing assay for transposase-accessessable chromatin using sequencing" ;
  rdfs:comment "An assay for transposase-accessible chromatin that uses sequencing which involves single cell combinatorial indexing ('sci-') strategy where nucleic acids from each of many cells are uniquely tagged through several rounds of split-pool barcoding which enables identification of single cells without single cell isolation."@en ;
  rdfs:subClassOf obo:OBI_0002039 .

obo:OBI_2100071 a rdfs:Class ;
  rdfs:label "liver injury venous blood human aspartate aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a liver injury order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100019 .

obo:OBI_0003886 a rdfs:Class ;
  rdfs:label "NAI RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 2-methylnicotinic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001596 a rdfs:Class ;
  rdfs:label "PDB file chain" ;
  rdfs:comment "A 3D structural organization datum that is part of a PDB file and has a specific chain identifier that identifies the entire information on a subset of the material entities."@en ;
  rdfs:subClassOf obo:OBI_0001155 .

obo:OBI_2100340 a rdfs:Class ;
  rdfs:label "liver function venous blood human aspartate aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a liver function order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100019 .

obo:OBI_0002697 a rdfs:Class ;
  rdfs:label "insecticide resistance by detecting enzyme activity assay" ;
  rdfs:comment "An insecticide resistance assay that is based on determination the catalytic activity of an enzyme associated with insecticide resistance phenotypes."@en ;
  rdfs:subClassOf obo:OBI_0002695 .

obo:OMRSE_00000056 a rdfs:Class ;
  rdfs:label "hospital organization"@en ;
  rdfs:comment "An organization that is the bearer of a hospital role."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0001643 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific immunoglobulin-mediated neutralization" ;
  rdfs:comment "A B cell epitope dependent biological activity determination assay that detects neutralization of the antigen."@en ;
  rdfs:subClassOf obo:OBI_0001706 .

obo:OBI_0002109 a rdfs:Class ;
  rdfs:label "Human 6x630K CGH Whole Genome Tiling Array" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 6x630,000 features."@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_0003825 a rdfs:Class ;
  rdfs:label "acidity quality assay" ;
  rdfs:comment "An assay that measures the acidity of a specimen on the pH scale."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001412 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific RANTES production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects RANTES production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001232 , obo:OBI_0003115 .

obo:OBI_0003181 a rdfs:Class ;
  rdfs:label "indirect bilirubin concentration assay" ;
  rdfs:comment "A bilirubin IXalpha assay that measures the concentration of indirect bilirubin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100018 .

obo:OBI_0003184 a rdfs:Class ;
  rdfs:label "mean cell hemoglobin concentration assay" ;
  rdfs:comment "A hemoglobin assay that measures the concentration of hemoglobin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100014 .

obo:OBI_0003331 a rdfs:Class ;
  rdfs:label "raw image data set" ;
  rdfs:comment "An image data set that encodes measurement values produced by some instrument before undergoing a data transformation."@en ;
  rdfs:subClassOf obo:OBI_0003327 .

obo:OBI_2100313 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0000055 a rdfs:Class ;
  rdfs:label "software optimization objective"@en ;
  rdfs:comment "Software_optimization is a software_testing_objective role describing a study designed to identify the best software or parameters of the software."@en ;
  rdfs:subClassOf obo:OBI_0000242 .

obo:OBI_0000593 a rdfs:Class ;
  rdfs:label "cation trap column" ;
  rdfs:comment "A cation trap column is a trap column and ion-exchange column which contains anionic cation-exchange resins."@en ;
  rdfs:subClassOf obo:OBI_0000518 .

obo:GO_0032641 a rdfs:Class ;
  rdfs:label "lymphotoxin A production" ;
  rdfs:comment "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." ;
  rdfs:subClassOf obo:GO_0071706 .

obo:OBI_0302737 a rdfs:Class ;
  rdfs:label "PCR-SSCP assay" ;
  rdfs:comment "An assay that identifies DNA sequence variation (mutation, deletion, insertions) in target DNA sequences amplified using polymerase chain reaction using gel electrophoresis and denaturating conditions"@en ;
  rdfs:subClassOf obo:OBI_0000435 , obo:OBI_0002692 .

obo:UBERON_0002106 a rdfs:Class ;
  rdfs:label "spleen" ;
  rdfs:comment "The organ that functions to filter blood and to store red corpuscles and platelets." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:COB_0000083 a rdfs:Class ;
  rdfs:label "failed planned process"@en ;
  rdfs:subClassOf obo:COB_0000082 .

obo:OBI_0003736 a rdfs:Class ;
  rdfs:label "genetic characteristic assay" ;
  rdfs:comment "An assay that produces information about a genetic characteristic of an organism."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000697 a rdfs:Class ;
  rdfs:label "Helicos sequencing assay" ;
  rdfs:comment "A DNA sequencing by synthesis assay that identifiies the sequnece of billions of DNA molecules immobilized to a surface using DNA polymerase and fluorescently labeled nucleotides added one at a time. The sequencing process does not require an amplification step and is typically able to produce reads of 25 base pair length."@en ;
  rdfs:subClassOf obo:OBI_0000734 .

obo:OBI_0400114 a rdfs:Class ;
  rdfs:label "sonicator" ;
  rdfs:comment "A device that converts a variable electrical current to mechanical vibration of a metallic probe. The device is used for the lysis of cells, the mixing of compounds or solutions, to framgent molecules of DNA, or to create emulsions."@en ;
  rdfs:subClassOf obo:OBI_0001033 .

obo:OBI_0002046 a rdfs:Class ;
  rdfs:label "surface plasmon resonance sensor chip" ;
  rdfs:comment "A device that is used as a binding surface for ligand during a surface plasmon resonance assay, consisting of a glass plate to which a metal film is attached"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000945 a rdfs:Class ;
  rdfs:label "vibration isolation table" ;
  rdfs:comment "A device  that supports another device such as a precision instrument by isolating it from vibration that is transmitted from the floor."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_0000470 a rdfs:Class ;
  rdfs:label "mass spectrometry assay" ;
  rdfs:comment "An assay that identifies the amount and type of material entities present in a sample by fragmenting the sample and measuring the mass-to-charge ratio of the resulting particles."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001307 a rdfs:Class ;
  rdfs:label "tiling microarray" ;
  rdfs:comment "A DNA microarray which has short fragments of nucleic acid immobilized on a substrate. These are designed to cover the whole genome of the target species. Tiling arrays are used to determine genome binding in ChIP assays or to identify transcribed regions."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0200066 a rdfs:Class ;
  rdfs:label "Holm-Bonferroni family-wise error rate correction method"@en ;
  rdfs:comment "a data transformation that performs more than one hypothesis test simultaneously, a closed-test procedure, that  controls the familywise error rate for all the k hypotheses at level α in the strong sense. Objective: multiple testing correction"@en ;
  rdfs:subClassOf obo:OBI_0200073 .

obo:OBI_0002582 a rdfs:Class ;
  rdfs:label "sequence library feature count data" ;
  rdfs:comment "The results of a sequence data feature count tabulation."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0001417 a rdfs:Class ;
  rdfs:label "ChIP-chip by tiling array design" ;
  rdfs:comment "A study design which aims to identify protein binding sites in genomic DNA by a combination of chromatin immunoprecipitation and tiling microarray (chip) assays."@en ;
  rdfs:subClassOf obo:OBI_0001403 .

obo:OBI_0001830 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-17F production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-17F production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001354 , obo:OBI_0001772 , obo:OBI_0600031 .

obo:UPHENO_0001001 a rdfs:Class ;
  rdfs:label "phenotype" ;
  rdfs:comment "A phenotypic effect related to http://www.w3.org/2002/07/owl#Thing." ;
  rdfs:subClassOf obo:PATO_0000001 .

obo:OBI_0003144 a rdfs:Class ;
  rdfs:label "IC50 binding datum" ;
  rdfs:comment "A quantitative binding datum that is expressed as a half-maximal inhibitory concentration (IC50)."@en ;
  rdfs:subClassOf obo:OBI_0001191 , obo:OBI_0003142 .

obo:OBI_0000985 a rdfs:Class ;
  rdfs:label "growth condition intervention design" ;
  rdfs:comment "A study design in which the independent variable is the environmental condition in which the specimen is growing"@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:OBI_0001137 a rdfs:Class ;
  rdfs:label "protein sequencer" ;
  rdfs:comment "An device that is used to determine the order of amino acids in protein sequences."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0003229 a rdfs:Class ;
  rdfs:label "plasma proteomics assay" ;
  rdfs:comment "A proteomics profiling assay that detects proteins in a blood plasma specimen."@en ;
  rdfs:subClassOf obo:OBI_0001318 .

obo:OBI_0001608 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring direct binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that detects direct binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001555 .

obo:UBERON_0000481 a rdfs:Class ;
  rdfs:label "multi-tissue structure" ;
  rdfs:comment "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:GO_0045202 a rdfs:Class ;
  rdfs:label "synapse" ;
  rdfs:comment "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." ;
  rdfs:subClassOf obo:GO_0005575 .

obo:OBI_0001727 a rdfs:Class ;
  rdfs:label "RIA measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A radio immuno assay that measures the dissociation constant [KD] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000910 , obo:OBI_0001708 .

obo:OBI_2100036 a rdfs:Class ;
  rdfs:label "elemental oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of elemental oxygen"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000447 a rdfs:Class ;
  rdfs:label "intracellular electrophysiology recording assay" ;
  rdfs:comment "An electrophysiology assay where the recording location of the electrode is intracellular."@en ;
  rdfs:subClassOf obo:OBI_0002176 .

obo:OBI_0000582 a rdfs:Class ;
  rdfs:label "Bruker LC-NMR/MS platform" ;
  rdfs:comment "Includes the connection to a high-resolution TOF-LC-MS system."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:OBI_0002694 a rdfs:Class ;
  rdfs:label "DNA fingerprinting assay" ;
  rdfs:comment "An assay to identify a specific individual organism from a DNA specimen by looking at unique patterns in their DNA."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001675 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-17A production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-17A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001773 , obo:OBI_1110162 .

obo:GO_0032601 a rdfs:Class ;
  rdfs:label "connective tissue growth factor production" ;
  rdfs:comment "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_2100165 a rdfs:Class ;
  rdfs:label "venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:OBI_0200015 a rdfs:Class ;
  rdfs:label "loess global transformation two-channel"@en ;
  rdfs:comment "A loess global transformation two-channel is a loess global transformation in the special case where the input the result of an MA transformation applied to intensities from the two channels of a two-channel assay."@en ;
  rdfs:subClassOf obo:OBI_0200023 .

obo:OBI_0001031 a rdfs:Class ;
  rdfs:label "array image creation" ;
  rdfs:comment "An image creation process that generate an image from the array."@en ;
  rdfs:subClassOf obo:OBI_0001007 .

obo:CL_0000786 a rdfs:Class ;
  rdfs:label "plasma cell" ;
  rdfs:comment "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." ;
  rdfs:subClassOf obo:CL_0000542 .

obo:OBI_0003838 a rdfs:Class ;
  rdfs:label "rate of action potentials in neuron burst assay" ;
  rdfs:comment "An electrophysiology assay that measures the number of action potential spikes occurring within a neuron burst"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0002176 .

obo:OBI_0002132 a rdfs:Class ;
  rdfs:label "pulse stable isotope labeling by amino acids in cell culture" ;
  rdfs:comment "An assay that detects differences in protein abundance using samples that have been metabolically labeled in vivo with a stable non-radioactive heavy isotope containing amino acid for a short period of time. After diluting the pulsed cells into growth media without label, high resolution mass spectrometry-based proteomics is used to analyze the time-dependent decay and determine protein stability."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:PATO_0001842 a rdfs:Class ;
  rdfs:label "acidity" ;
  rdfs:comment "A concentration quality inhering in a bearer by virtue of the bearer's containing acid (hydrogen ions)." ;
  rdfs:subClassOf obo:PATO_0000033 .

obo:OBI_1110170 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-10 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001209 , obo:OBI_0600031 .

obo:PR_000008457 a rdfs:Class ;
  rdfs:label "beta-globin" ;
  rdfs:comment "A hemoglobin subunit that is a translation product of the human HBB gene, a 1:1 ortholog thereof, or pro-orthologs thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_1110041 a rdfs:Class ;
  rdfs:label "lymph node cell specimen" ;
  rdfs:comment "A cell specimen comprised of a mixed population of cells obtained by processing whole lymph node into individual cells, typically performed using a sieve. This population includes T cells, B cells, macrophages, and other cell types."@en ;
  rdfs:subClassOf obo:OBI_0001468 .

obo:OBI_0001773 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-17A production by T cells" ;
  rdfs:comment "An assay of epitope specific interleukin-17 production by T cells that detects interleukin-17A production."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001295 .

obo:PR_000007928 a rdfs:Class ;
  rdfs:label "glial cell line-derived neurotrophic factor" ;
  rdfs:comment "A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:PATO_0000047 a rdfs:Class ;
  rdfs:label "biological sex" ;
  rdfs:comment "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved." ;
  rdfs:subClassOf obo:PATO_0001995 .

obo:OBI_0400009 a rdfs:Class ;
  rdfs:label "arc lamp" ;
  rdfs:comment "Arc lamp is a light source that produces light by an electric arc (or voltaic arc). The lamp consists of two electrodes typically made of tungsten which are separated by a gas. The type of lamp is often named by the gas contained in the bulb; including neon, argon, xenon, krypton, sodium, metal halide, and mercury. The electric arc in an arc lamp consists of gas which is initially ionized by a voltage and is therefore electrically conductive. To start an arc lamp, usually a very high voltage is needed to ignite or strike the arc. This requires an electrical circuit sometimes called an igniter, which is part of a larger circuit called the ballast. The ballast supplies a suitable voltage and current to the lamp as its electrical characteristics change with temperature and time. Older cytometers may use arc lamps to irradiate particles at the interrogation point."@en ;
  rdfs:subClassOf obo:OBI_0400065 .

obo:OBI_0000487 a rdfs:Class ;
  rdfs:label "fourier transformation NMR instrument" ;
  rdfs:comment "In fourier transformation NMR, all frequencies in a spectrum are irradiated simultaneously with a radio frequency pulse. Following the pulse, the nuclei return to thermal equilibrium. A time domain emission signal is recorded by the instrument as the nuclei relax. A frequency domain spectrum is obtained by Fourier transformation."@en ;
  rdfs:subClassOf obo:OBI_0000566 .

obo:OBI_0002117 a rdfs:Class ;
  rdfs:label "whole genome sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that intends to provide information about the sequence of an entire genome of an organism."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:NCBITaxon_2759 a rdfs:Class ;
  rdfs:label "Eukaryota" ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0001368 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects tumor necrosis factor superfamily cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001400 , obo:OBI_0003115 .

obo:OBI_0200003 a rdfs:Class ;
  rdfs:label "logit-log curve fitting"@en ;
  rdfs:comment "A logit-log curve fitting is a curve fitting where first the limits y_0 an y_infty of y when x->0 and x->infinity, respectively, are estimated from the input data points (x_1, y_1), (x_2,y_2), ..., (x_n, y_n). Then a curve with equation log((y-y_0)/(y_infty-y))=a+b log(x) is obtained, where a and b are determined to optimize its fit to the input data points."@en ;
  rdfs:subClassOf obo:OBI_0200072 .

obo:OBI_0001068 a rdfs:Class ;
  rdfs:label "SPECT scanner" ;
  rdfs:comment "A nuclear medicine tomographic imaging device that uses gamma rays to provide 3D information, typically presented as cross-sectional slices through the specimen but with the ability to be freely reformatted or manipulated as required."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0001229 a rdfs:Class ;
  rdfs:label "plasmon resonance assay measuring the dissociation constant [KD] of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A surface plasmon resonance binding assay that measures the dissociation constant [KD] of an epitope:MHC complex binding with a T cell receptor."@en ;
  rdfs:subClassOf obo:OBI_0000923 , obo:OBI_0002097 .

obo:OBI_2100374 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0001391 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-12 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:CHEBI_16113 a rdfs:Class ;
  rdfs:label "cholesterol" ;
  rdfs:comment "A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3β-hydroxy group." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002526 a rdfs:Class ;
  rdfs:label "skin of body specimen" ;
  rdfs:comment "A specimen that is derived from skin."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100025 a rdfs:Class ;
  rdfs:label "creatine kinase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatine kinase"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:OBI_0001542 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-13 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001251 .

obo:CHEBI_168396 a rdfs:Class ;
  rdfs:label "mycophenolic acid" ;
  rdfs:comment "A member of the class of 2-benzofurans that is 2-benzofuran-1(3<em>H</em>)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2<i>E</i>)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by <em>Penicillium brevi-compactum, P. stoloniferum, P. echinulatum</em> and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:PATO_0001548 a rdfs:Class ;
  rdfs:label "quality of a liquid" ;
  rdfs:comment "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." ;
  rdfs:subClassOf obo:PATO_0002198 .

obo:OBI_0003905 a rdfs:Class ;
  rdfs:label "neural network spike rate assay" ;
  rdfs:comment "An multi-electrode assay that measures the number of events when multiple electrodes simultaneously detect an action potential during a time period."@en ;
  rdfs:subClassOf obo:OBI_0003901 .

obo:CHEBI_166899 a rdfs:Class ;
  rdfs:label "globulin type" ;
  rdfs:comment "One of the major classifications of proteins, which may be further divided into the euglobulins and the pseudoglobulins. The former group is insoluble in water but soluble in saline solutions and may be precipitated in water that has been half-saturated with a salt such as ammonium sulfate. The latter group is soluble in water and has properties that resemble those of the true globulins. Globulins are an important source of protein in seed plants and are found in minute amounts in cereals. Globulins found in animal fluids are enzymes, antibodies, and fibrous and contractile proteins usually contained in the blood plasma." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003752 a rdfs:Class ;
  rdfs:label "oligodendrocyte differentiation assay" ;
  rdfs:comment "A cell differentiation assay that measures differentiation of oligodendrocytes."@en ;
  rdfs:subClassOf obo:OBI_0003720 .

obo:OBI_0002026 a rdfs:Class ;
  rdfs:label "Human Genome U133 tiling array" ;
  rdfs:comment "A tiling array which is manufactured by the Affymetrix corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 39,000 transcripts and variants."@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_0001686 a rdfs:Class ;
  rdfs:label "in-situ hybridization assay" ;
  rdfs:comment "An assay that localizes a specific DNA or RNA sequence within a portion or section of tissue using artificially induced nucleic hybridization."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003101 a rdfs:Class ;
  rdfs:label "nanospray desorption electrospray ionization assay" ;
  rdfs:comment "A mass spectrometry assay that analyzes organic and biological molecules on a substrate by desorption of an analyte into a solvent bridge formed between two capillaries and the analysis surface. One capillary supplies solvent to create and maintain the bridge, while the second capillary transports the dissolved analyte from the bridge to the mass spectrometer. A high voltage applied between the inlet of mass spectrometer and the primary capillary creates a self-aspirating nanospray."@en ;
  rdfs:subClassOf obo:OBI_0000470 .

obo:OBI_0000823 a rdfs:Class ;
  rdfs:label "thrombin time assay" ;
  rdfs:comment "An assay that measures the time between the addition of the thrombin and the clot formation in plasma."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003371 a rdfs:Class ;
  rdfs:label "epitope specific XCL1 release by T cells" ;
  rdfs:comment "A biological process where T cells produce XCL1 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0140779 , obo:OBI_0001193 .

obo:OBI_0000140 a rdfs:Class ;
  rdfs:label "obsolete_label role" ;
  rdfs:comment "Label role is a role which inheres in a material entity and which is realized in a detection of label assay"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002407 a rdfs:Class ;
  rdfs:label "pill delivery form for hormonal replacement therapy" ;
  rdfs:comment "A delivery form for hormonal replacement therapy that is a pill for oral administration."@en ;
  rdfs:subClassOf obo:OBI_0002406 .

obo:OBI_0000991 a rdfs:Class ;
  rdfs:label "Edinburgh score" ;
  rdfs:comment "A score that measures the dominance of a person's right or left hand in everyday activities."@en ;
  rdfs:subClassOf obo:OBI_0000970 .

obo:OBI_0002976 a rdfs:Class ;
  rdfs:label "input protein sequence stop site" ;
  rdfs:comment "The position of the last amino acid in a protein sequence being analyzed (input protein sequence)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0003760 a rdfs:Class ;
  rdfs:label "cell viability assay based on detection of resorufin using fluorescence to qualtify the presence of resorufin." ;
  rdfs:comment "A cell viability assay based on detection of resorufin that uses fluorescence to quantify resorufin"@en ;
  rdfs:subClassOf obo:OBI_0003757 .

obo:OBI_0002994 a rdfs:Class ;
  rdfs:label "presence of blood from host organism in blood meal specimen" ;
  rdfs:comment "A data item that indicates whether blood in a blood meal specimen came from a specified host organism."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:UBERON_0001981 a rdfs:Class ;
  rdfs:label "blood vessel" ;
  rdfs:comment "A vessel through which blood circulates in the body." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:IAO_0000079 a rdfs:Class ;
  rdfs:label "density plot"@en ;
  rdfs:comment "A density plot is a report graph which is a graphical representation of data where the tint of a particular pixel corresponds to some kind of function corresponding the the amount of data points relativelly with their distance from the the pixel."@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:OBI_2100111 a rdfs:Class ;
  rdfs:label "venous blood prealbunin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of prealbunin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0001206 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects granulocyte macrophage colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001233 , obo:OBI_0600031 .

obo:GO_0042101 a rdfs:Class ;
  rdfs:label "T cell receptor complex" ;
  rdfs:comment "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." ;
  rdfs:subClassOf obo:OBI_1110022 .

obo:OBI_0001484 a rdfs:Class ;
  rdfs:label "assay measuring T cell epitope specific in vivo activity" ;
  rdfs:comment "A T cell epitope dependent biological activity determination assay that uses an in vivo intervention experiment."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002055 .

obo:OBI_0001679 a rdfs:Class ;
  rdfs:label "yeast 2-hybrid assay" ;
  rdfs:comment "An assay that detects protein protein interactions and protein DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively. The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the binding domain (BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. The Y2H is thus a protein-fragment complementation assay."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0002988 a rdfs:Class ;
  rdfs:label "specimen collection duration" ;
  rdfs:comment "A time measurement datum that is the count of collection cycles over which a specimen collection process occurs."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0002154 a rdfs:Class ;
  rdfs:label "CMV antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to cytomegalovirus (CMV) antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0200152 a rdfs:Class ;
  rdfs:label "polynomial degree"@en ;
  rdfs:comment "The polynomial degree is a feature of a polynomial function defined as the highest power of the polynomial's terms, where the terms of a polynomial are the individual summands with the coefficients omitted."@en ;
  rdfs:subClassOf obo:OBI_0200140 .

obo:UBERON_0006618 a rdfs:Class ;
  rdfs:label "atrium auricular region" ;
  rdfs:comment "A small conical pouch projections located on the upper anterior portion of each atrium of the heart." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:OBI_0003212 a rdfs:Class ;
  rdfs:label "phospholipid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of phospholipid"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003781 a rdfs:Class ;
  rdfs:label "proteomics by mass spectrometry assay" ;
  rdfs:comment "A mass spectrometry assay that identifies and measures proteins."@en ;
  rdfs:subClassOf obo:OBI_0000615 .

obo:IDO_0000666 a rdfs:Class ;
  rdfs:label "human pathogenicity disposition"@en ;
  rdfs:comment "A disposition to initiate processes that result in a disorder in a human organism." ;
  rdfs:subClassOf obo:IDO_0000450 .

obo:OBI_2100064 a rdfs:Class ;
  rdfs:label "CBC with automated differential venous blood WBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of WBCs in venous blood as part of a CBC with automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:OBI_0001278 a rdfs:Class ;
  rdfs:label "DNA methylation profiling by array design" ;
  rdfs:comment "A study design in which the methylation state of DNA is determined and is compared between samples using array technology."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003242 a rdfs:Class ;
  rdfs:label "induced sputum microbiology assay" ;
  rdfs:comment "An organism detection assay that detects microorganisms in an induced sputum specimen."@en ;
  rdfs:subClassOf obo:OBI_0003234 , obo:OBI_0003498 .

obo:OBI_0002806 a rdfs:Class ;
  rdfs:label "footwear cover" ;
  rdfs:comment "A personal protective device which is an impermiable material which covers a shoe or boot in order to prevent spread of specific environmental contaminants."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:OBI_0002669 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific helper T cell enhancement of a B cell mediated immune response resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance an antibody response after adoptive transfer of epitope specfic T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001228 , obo:OBI_0002676 .

obo:CL_0000451 a rdfs:Class ;
  rdfs:label "dendritic cell" ;
  rdfs:comment "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." ;
  rdfs:subClassOf obo:CL_0000842 .

obo:OBI_0002037 a rdfs:Class ;
  rdfs:label "micrococcal nuclease digestion followed by tiling array assay" ;
  rdfs:comment "An array based nucleic acid structure mapping assay that identifies nucleosome positions genome wide, by detection of regions protected by nucleosomes from digestion by micrococal nuclease using tiling array assays"@en ;
  rdfs:subClassOf obo:OBI_0002036 .

obo:OBI_0001159 a rdfs:Class ;
  rdfs:label "age since egg laying measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since egg laying, the process of the production of egg(s) by an organism."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0400091 a rdfs:Class ;
  rdfs:label "cytometer sample tube" ;
  rdfs:comment "A particle delivery vessel. The cytometer sample tube is a vessel in which the sample is introduced to the cytometer. Frequently the tube is placed on the cytometer in such a manner that a seal is formed between the tube and cytometer, and gas is used to create enough pressure to push the sample out of the tube and into the cytometer."@en ;
  rdfs:subClassOf obo:OBI_0000836 .

obo:OBI_0000455 a rdfs:Class ;
  rdfs:label "consume data function"@en ;
  rdfs:comment "Process data function is a function that is borne by in a material entity by virtue of its structure. When realized the material entity consumes data."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_2100120 a rdfs:Class ;
  rdfs:label "venous blood prostate specific antigen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of prostate specific antigen in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100034 .

obo:GO_0032623 a rdfs:Class ;
  rdfs:label "interleukin-2 production" ;
  rdfs:comment "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003628 a rdfs:Class ;
  rdfs:label "antibody purification of H2-Dd protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003627 , obo:OBI_0003632 .

obo:OBI_0003207 a rdfs:Class ;
  rdfs:label "very-low-density lipoprotein concentration assay" ;
  rdfs:comment "A lipoprotein concentration assay that measures the concentration of very-low-density lipoprotein in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003204 .

obo:OBI_2100302 a rdfs:Class ;
  rdfs:label "bone profile venous blood phosphate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of phosphate in venous blood as part of a bone profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100015 .

obo:OBI_0003809 a rdfs:Class ;
  rdfs:label "Transepithelial Electrical Resistance (TEER) device" ;
  rdfs:comment "A measurement device that measures monolayer barrier integrity via measurement of membrane potential and electrical resistance across a cell monolayer in culture."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0100069 a rdfs:Class ;
  rdfs:label "obsolete_polymer" ;
  rdfs:comment "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003816 a rdfs:Class ;
  rdfs:label "distance measurement assay" ;
  rdfs:comment "An assay that measures the space between two entities."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003382 a rdfs:Class ;
  rdfs:label "placental blood microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a placental blood microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003244 .

obo:CHEBI_51756 a rdfs:Class ;
  rdfs:label "Alexa Fluor 532" ;
  rdfs:subClassOf obo:OBI_0002744 .

obo:UBERON_0001004 a rdfs:Class ;
  rdfs:label "respiratory system" ;
  rdfs:comment "Functional system which consists of structures involved in respiration." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OBI_2100396 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid eosinophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of eosinophils in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003023 , obo:OBI_0003232 .

obo:OBI_0002161 a rdfs:Class ;
  rdfs:label "systematic evolution of ligands by exponential enrichment assay" ;
  rdfs:comment "A binding assay that identifies protein-binding sites on nucleic acids by selecting high-affinity target ligands from a randomized pool. The process is repeated in rounds, then the bound nucleic acids are separated from the unbound nucleic acids and amplified by PCR._"@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0002578 a rdfs:Class ;
  rdfs:label "adapter sequence data" ;
  rdfs:comment "Nucleotide sequences of molecules that are ligated to assay samples prior to sequencing of these samples;  these sequences are provided by assay kit manufacturers and typically used to combine sequencing of multiple samples in one assay run."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001210 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects transforming growth factor-beta production by T cells"@en ;
  rdfs:subClassOf obo:OBI_0001264 , obo:OBI_0003115 .

obo:OBI_2100205 a rdfs:Class ;
  rdfs:label "urine protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in urine"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100023 .

obo:OBI_0002741 a rdfs:Class ;
  rdfs:label "organism detection by specific DNA hybridization assay" ;
  rdfs:comment "An organism detection assay that is based on DNA hybrdization."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:GO_0022414 a rdfs:Class ;
  rdfs:label "reproductive process" ;
  rdfs:comment "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001466 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-12 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001391 .

obo:OBI_0002961 a rdfs:Class ;
  rdfs:label "global chromatin profiling by mass spectrometry assay" ;
  rdfs:comment "A type of epigenetic modification assay that employs targeted quantitative mass spectrometry to profile modifications of the core histones of chromatin."@en ;
  rdfs:subClassOf obo:OBI_0002020 .

obo:OBI_0003393 a rdfs:Class ;
  rdfs:label "Affymetrix Mouse Gene 1.0 ST Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, which is a whole-transcript array that includes probes to measure both messenger (mRNA) and long intergenic non-coding RNA transcripts (lincRNA). This whole-transcript array design provides a complete expression profile of mRNA as well as the intermediary lincRNA transcripts that impact the mRNA expression profile."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:GO_0140058 a rdfs:Class ;
  rdfs:label "neuron projection arborization" ;
  rdfs:comment "The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0003687 a rdfs:Class ;
  rdfs:label "m6A-MTase sequencing assay" ;
  rdfs:comment "A DNA methylation profiling assay in which chromatin stencils are created by treating nuclei with m6A methyltransferase (MTase) and then sequenced using single-molecule circular consensus sequencing to identify regions of accessible DNA at nucleotide resolution."@en ;
  rdfs:subClassOf obo:OBI_0003686 .

obo:OBI_0600034 a rdfs:Class ;
  rdfs:label "precipitation"@en ;
  rdfs:comment "a protocol application to cause a material to precipitate (becoming a solid) out of solution. Input is a solution, output is a solution plus a solid component (the precipitate)"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0001660 a rdfs:Class ;
  rdfs:label "intracellular material detection assay measuring epitope specific granzyme A release by T cells" ;
  rdfs:comment "A flow cytometry assay that detects epitope specific granzyme A release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001809 .

obo:OBI_0000174 a rdfs:Class ;
  rdfs:label "study group role"@en ;
  rdfs:comment "a study population role where the bearer is a population of material entities and the role is realized in the implementation of a study design wherein the entities bearing the study population role are observed or subjected to intervention according to the study design and are biological replicates, i.e. they receive the same treatment under the protocol"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_2100014 a rdfs:Class ;
  rdfs:label "hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:GO_0032991 a rdfs:Class ;
  rdfs:label "protein-containing complex" ;
  rdfs:comment "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
  rdfs:subClassOf obo:COB_0000080 , obo:GO_0005575 .

obo:UBERON_0001970 a rdfs:Class ;
  rdfs:label "bile" ;
  rdfs:comment "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0002441 a rdfs:Class ;
  rdfs:label "physical examination of an organism" ;
  rdfs:comment "An assay that produces a description of the qualities of an organism that has not been transformed, through observation and physical, non-invasive techniques."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0200127 a rdfs:Class ;
  rdfs:label "weighted network graph construction"@en ;
  rdfs:comment "A network graph construction in which an input data set describing objects and quantitative relationships between objects is transformed into and output representation of these objects as nodes and the quantitative relationships as weighted edges of a network graph."@en ;
  rdfs:subClassOf obo:OBI_0200126 .

obo:PATO_0001894 a rdfs:Class ;
  rdfs:label "phenotypic sex" ;
  rdfs:comment "An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics." ;
  rdfs:subClassOf obo:PATO_0000047 .

obo:NCBITaxon_716545 a rdfs:Class ;
  rdfs:label "saccharomyceta" ;
  rdfs:subClassOf obo:NCBITaxon_4890 .

obo:OBI_1110084 a rdfs:Class ;
  rdfs:label "effector T cell function"@en ;
  rdfs:comment "The function inhering in a T cell that is realized in an immune response that results from the T cell receptor binding to the MHC:epitope complex."@en ;
  rdfs:subClassOf obo:OBI_1110016 .

obo:OBI_0001042 a rdfs:Class ;
  rdfs:label "pump function" ;
  rdfs:comment "a transfer unction where the transfer requires work to move the entity, often against a gradient."@en ;
  rdfs:subClassOf obo:OBI_0000383 .

obo:OBI_0000049 a rdfs:Class ;
  rdfs:label "mass spectrometer" ;
  rdfs:comment "A mass spectrometer is an instrument which is used to measure the mass to charge ratio of ions. All mass spectrometers consist of three basic parts: an ion source, a mass analyzer, and a detector system. The stages within the mass spectrometer are: 1. Production of ions from the sample 2. Separation of ions with different masses 3. Detection of the number of ions of each mass produced 4.Collection of data to generate the mass spectrum"@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_1110048 a rdfs:Class ;
  rdfs:label "cultured CD3- T cell population"@en ;
  rdfs:comment "A T cell population characterized by not expressing the CD3 molecule on its surface."@en ;
  rdfs:subClassOf obo:OBI_0001875 .

obo:OBI_0002514 a rdfs:Class ;
  rdfs:label "peritoneal fluid specimen" ;
  rdfs:comment "A specimen that is derived from peritoneal fluid."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0002048 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 3000" ;
  rdfs:comment "A DNA sequencer manufactured by Illumina corporation, with a single flow cell and a throughput of more than 200 Gb per day."@en ;
  rdfs:subClassOf obo:OBI_0003683 .

obo:OBI_2100351 a rdfs:Class ;
  rdfs:label "bodily fluid albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in bodily fluid"@en ;
  rdfs:subClassOf obo:OBI_2100022 .

obo:OBI_0003804 a rdfs:Class ;
  rdfs:label "color detection assay" ;
  rdfs:comment "An assay that measures the color of the evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:CHMO_0000087 a rdfs:Class ;
  rdfs:label "fluorescence microscopy assay" ;
  rdfs:comment "Any type of light microscopy assay where the specimen can be made to fluoresce (emit energy as visible light) by illuminating it with light of specific wavelengths. These specimens are called fluorophores."@en ;
  rdfs:subClassOf obo:CHMO_0000102 , obo:OBI_0001501 .

obo:OBI_0002539 a rdfs:Class ;
  rdfs:label "tibial nerve specimen" ;
  rdfs:comment "A specimen that is derived from tibial nerve."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0200036 a rdfs:Class ;
  rdfs:label "Benjamini and Hochberg false discovery rate correction method"@en ;
  rdfs:comment "A data transformation process in which the Benjamini and Hochberg method sequential p-value procedure  is applied with the aim of correcting false discovery rate"@en ;
  rdfs:subClassOf obo:OBI_0200163 .

obo:OBI_2100093 a rdfs:Class ;
  rdfs:label "basic metabolic panel venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a basic metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:CHEBI_24636 a rdfs:Class ;
  rdfs:label "proton" ;
  rdfs:comment "Nuclear particle of charge number +1, spin ½ and rest mass of 1.007276470(12) u." ;
  rdfs:subClassOf obo:CHEBI_36342 , obo:COB_0000013 .

obo:OBI_0001659 a rdfs:Class ;
  rdfs:label "flow cytometry assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A flow cytometry assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001703 .

obo:OBI_0200118 a rdfs:Class ;
  rdfs:label "quantile calculation"@en ;
  rdfs:comment "A quantile calculation is a descriptive statistics calculation in which the kth quantile is the data value for which an approximate k fraction of the data is less than or equal to that value.  See http://www.stat.wvu.edu/SRS/Modules/Quantiles/quantiles.html for details."@en ;
  rdfs:subClassOf obo:OBI_0200184 .

obo:OBI_0100060 a rdfs:Class ;
  rdfs:label "cultured cell population" ;
  rdfs:comment "A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0400087 a rdfs:Class ;
  rdfs:label "preamplifier" ;
  rdfs:comment "A preamplifier is part of the electronics subsystem. It converts the current output from its associated detector to a voltage. The preamplifier is the first stage in analog electronics signal processing."@en ;
  rdfs:subClassOf obo:OBI_0400101 .

obo:PR_000003252 a rdfs:Class ;
  rdfs:label "antithrombin-III" ;
  rdfs:comment "A serpin that is a translation product of the human SERPINC1 gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_2100053 a rdfs:Class ;
  rdfs:label "panel5 venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a panel5 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0003173 a rdfs:Class ;
  rdfs:label "triglyceride concentration assay" ;
  rdfs:comment "A triglyceride assay that measures the concentration of triglycerides in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100029 .

obo:OBI_2100144 a rdfs:Class ;
  rdfs:label "electrolytes urine sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in urine as part of a electrolytes order"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100002 .

obo:OBI_0003659 a rdfs:Class ;
  rdfs:label "in vitro CRISPR screen assay" ;
  rdfs:comment "An assay in which cells expressing a Cas system are infected with a library of guide RNAs with the intent of causing a perturbation at the target of the guide RNAs."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0001175 a rdfs:Class ;
  rdfs:label "selective organism creation objective"@en ;
  rdfs:comment "an objective specification to generate a population or type of organism within species that have some uniform behavioral, morphological, physiological, or genetic characteristics with similarly bred organisms."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:UBERON_0001987 a rdfs:Class ;
  rdfs:label "placenta" ;
  rdfs:comment "Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:GO_0043227 a rdfs:Class ;
  rdfs:label "membrane-bounded organelle" ;
  rdfs:comment "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." ;
  rdfs:subClassOf obo:GO_0005575 .

obo:OBI_0000718 a rdfs:Class ;
  rdfs:label "pathogen role" ;
  rdfs:comment "pathogen role is a role which inheres in an organism and realized in the process of disease course in the organism bearing host role caused by the organism bearing pathogen role"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002106 a rdfs:Class ;
  rdfs:label "carboxyfluorescein succinimidyl ester staining assay" ;
  rdfs:comment "An assay using carboxyfluorescein succinimidyl ester staining."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001750 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific granulocyte colony stimulating factor production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects granulocyte colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001600 .

obo:UBERON_0000029 a rdfs:Class ;
  rdfs:label "lymph node" ;
  rdfs:comment "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0000415 a rdfs:Class ;
  rdfs:label "polymerase chain reaction"@en ;
  rdfs:comment "PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified."@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBI_0002138 a rdfs:Class ;
  rdfs:label "temperature value specification"@en ;
  rdfs:comment "A value specification that specifies the temperature of some thing."@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_2100219 a rdfs:Class ;
  rdfs:label "DT60 venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood as part of a DT60 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:NCBITaxon_6668 a rdfs:Class ;
  rdfs:label "Daphnia" ;
  rdfs:subClassOf obo:NCBITaxon_197562 .

obo:OBI_0003170 a rdfs:Class ;
  rdfs:label "reticulocyte percentage assay" ;
  rdfs:comment "A reticulocyte assay that measures the percentage of reticulocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003026 .

obo:OBI_0003054 a rdfs:Class ;
  rdfs:label "blood specimen in vacutainer" ;
  rdfs:comment "A blood specimen that is located in a vacutainer."@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_1110156 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-10 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001209 .

obo:OBI_0000830 a rdfs:Class ;
  rdfs:label "obsolete_primary structure of sequence macromolecule" ;
  rdfs:comment "A quality inhering in a molecule that is completely defined by the linear sequence of a set of residues which are connected by directional, linear bonds"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003330 a rdfs:Class ;
  rdfs:label "magnetic resonance imaging evaluant role"@en ;
  rdfs:comment "An evaluant role that inheres in a material entity that is realized in a MR imaging assay in which MR imaging data is generated about the bearer of the evaluant role."@en ;
  rdfs:subClassOf obo:OBI_0000067 .

obo:OBI_0000855 a rdfs:Class ;
  rdfs:label "total RNA extraction" ;
  rdfs:comment "A RNA extraction process in which total cellular and organelle RNA are extracted."@en ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBI_0003204 a rdfs:Class ;
  rdfs:label "lipoprotein concentration assay" ;
  rdfs:comment "An analyte assay that measures the abundance of lipoprotein"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003247 a rdfs:Class ;
  rdfs:label "urine assay datum" ;
  rdfs:comment "A data entity that is the specified output of a urine assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_2100172 a rdfs:Class ;
  rdfs:label "random venous blood vancomycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of vancomycin in venous blood as part of a random order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100044 .

obo:ENVO_01000813 a rdfs:Class ;
  rdfs:label "geophysical entity"@en ;
  rdfs:comment "A material part of an astronomical body." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003713 a rdfs:Class ;
  rdfs:label "organism development assay" ;
  rdfs:comment "A physical examination of an organism that provides information about some developmental process in that organism."@en ;
  rdfs:subClassOf obo:OBI_0002441 .

obo:OBI_0002600 a rdfs:Class ;
  rdfs:label "collecting specimen with swab" ;
  rdfs:comment "A specimen collection process that uses a swab as the collection device. A swab is an absorbent material (e.g. cotton) on a rod (e.g., wooden stick)."@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:UBERON_0000970 a rdfs:Class ;
  rdfs:label "eye" ;
  rdfs:comment "An organ that detects light." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_1000036 a rdfs:Class ;
  rdfs:label "cell lysate"@en ;
  rdfs:comment "a cell lysate is a material entity which is output of a cell lysis process"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003223 a rdfs:Class ;
  rdfs:label "insulin concentration assay" ;
  rdfs:comment "A insulin assay that measures the concentration of insulin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003222 .

obo:OBI_0003494 a rdfs:Class ;
  rdfs:label "Advantage Chikungunya IgM Card kit" ;
  rdfs:comment "An assay kit that is manufactured by J. Mitra to detect human IgM antibodies for Chikungunya virus with a protein microarray and double-antigen sandwich ELISA."@en ;
  rdfs:subClassOf obo:OBI_0003369 .

obo:OBI_0003916 a rdfs:Class ;
  rdfs:label "digital image channel" ;
  rdfs:comment "A data item that is a component of a digital image that represents spatially registered measurements collected for a specific spectral band, detector, or sensor output."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000245 a rdfs:Class ;
  rdfs:label "organization"@en ;
  rdfs:comment "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000563 a rdfs:Class ;
  rdfs:label "fluorescene detector" ;
  rdfs:comment "A single wavelength detector, where the excitation light wavelength is normally a mercury lamp generated high intensity UV light at 253.7 nm. Many substances that fluoresce will be excited by light of this wavelength and hence be detected."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:GO_0002514 a rdfs:Class ;
  rdfs:label "B cell tolerance induction" ;
  rdfs:comment "A process involving any mechanism for tolerance induction in B cells." ;
  rdfs:subClassOf obo:GO_0002507 .

obo:GO_0032636 a rdfs:Class ;
  rdfs:label "interleukin-7 production" ;
  rdfs:comment "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:CL_0000019 a rdfs:Class ;
  rdfs:label "sperm" ;
  rdfs:comment "A mature male germ cell that develops from a spermatid." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0000849 a rdfs:Class ;
  rdfs:label "organellar RNA extraction" ;
  rdfs:comment "A RNA extraction process in which the desired output material is RNA in the organelle(s)."@en ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBI_0001761 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-X-C motif) ligand 16 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-X-C motif) ligand 16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001778 .

obo:OBI_0001980 a rdfs:Class ;
  rdfs:label "in vivo intervention experiment" ;
  rdfs:comment "An assay in which the effect of a targeted process (the intervention) on an organism is tested."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_1110055 a rdfs:Class ;
  rdfs:label "obsolete_disease" ;
  rdfs:comment "placeholder to be imported from disease ontology"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002993 a rdfs:Class ;
  rdfs:label "prevalence of blood meal specimens from a host organism" ;
  rdfs:comment "A data item that is the frequency of blood whose source is from a specified host organism in collected blood meal specimens."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000974 a rdfs:Class ;
  rdfs:label "obsolete_right handedness" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100009 a rdfs:Class ;
  rdfs:label "monocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of monocytes"@en ;
  rdfs:subClassOf obo:OBI_0003025 .

obo:OBI_0000743 a rdfs:Class ;
  rdfs:label "immune response assay" ;
  rdfs:comment "An assay that determines information about an immune response"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003275 a rdfs:Class ;
  rdfs:label "bacteria in nasopharyngeal or oropharyngeal swab datum" ;
  rdfs:comment "A nasopharyngeal or oropharyngeal swab microbiology datum that is about bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003257 .

obo:OBI_0001798 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-9 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001253 .

obo:OBI_0003353 a rdfs:Class ;
  rdfs:label "T2* weighted GRE magnetic resonance image data set" ;
  rdfs:comment "T2* weighted image data set collected using a gradient echo sequence."@en ;
  rdfs:subClassOf obo:OBI_0003348 .

obo:OBI_0000368 a rdfs:Class ;
  rdfs:label "record function"@en ;
  rdfs:comment "A record function is a function that registers or collects information in a particular format on a particular recording medium. For example on paper or a digital representation"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0001716 a rdfs:Class ;
  rdfs:label "B cell epitope specific complement-dependent cytotoxicity" ;
  rdfs:comment "complement-dependent cytotoxicity resulting from antibody binding to epitope"@en ;
  rdfs:subClassOf obo:GO_0097278 .

obo:OBI_0001130 a rdfs:Class ;
  rdfs:label "vacuum oven" ;
  rdfs:comment "A device that heats materials in a vacuum."@en ;
  rdfs:subClassOf obo:OBI_0000967 , obo:OBI_0001034 .

obo:OBI_0001502 a rdfs:Class ;
  rdfs:label "epitope specific perforin production by T cells" ;
  rdfs:comment "The production of perforin, an immune mediator molecule involved in T cell degranulation,  resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0035944 .

obo:OBI_0002615 a rdfs:Class ;
  rdfs:label "disease specific study design" ;
  rdfs:comment "A study design for which material and information is collected from subjects that have already developed a particular disease."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:CHEBI_36342 a rdfs:Class ;
  rdfs:label "subatomic particle" ;
  rdfs:comment "A particle smaller than an atom." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0002897 a rdfs:Class ;
  rdfs:label "surveillance process"@en ;
  rdfs:comment "An investigation in which some entity is monitored, and data concerning that entity collected, interpreted, and disseminated, for the purpose of managing, directing, or protecting that entity, or some other entity."@en ;
  rdfs:subClassOf obo:OBI_0000066 .

obo:OBI_2100155 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood bilirubin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100018 .

obo:OBI_0002492 a rdfs:Class ;
  rdfs:label "case role in case-control study"@en ;
  rdfs:comment "A role that is borne by a case-control study design participant under investigation that is associated with the outcome mentioned in the study design."@en ;
  rdfs:subClassOf obo:OBI_0000097 .

obo:OBI_2100019 a rdfs:Class ;
  rdfs:label "aspartate aminotransferase (human) assay" ;
  rdfs:comment "An analyte assay that measures the abundance of aspartate aminotransferase (human)"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:OBI_0001459 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-X-C motif) ligand 9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002182 a rdfs:Class ;
  rdfs:label "voltage clamp assay" ;
  rdfs:comment "An cellular electrophysiology assay where the membrane potential of a cell is controlled by the experimentalist. This is accomplished through a feedback mechanism where any change in membrane potential is countered by permitting electrical current to flow into or out of the cell."@en ;
  rdfs:subClassOf obo:OBI_0000447 .

obo:OBI_0003258 a rdfs:Class ;
  rdfs:label "pleural fluid microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a pleural fluid microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 .

obo:OBI_0001900 a rdfs:Class ;
  rdfs:label "specimen identifier assigned by specimen repository"@en ;
  rdfs:comment "A specimen identifier which is assigned by a specimen repository"@en ;
  rdfs:subClassOf obo:OBI_0001616 .

obo:OBI_0500018 a rdfs:Class ;
  rdfs:label "replicate design" ;
  rdfs:comment "A replicate experimental design type is where a series of replicates are performed to evaluate reproducibility or as a pilot study to determine the appropriate number of replicates for a subsequent experiments."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_2100248 a rdfs:Class ;
  rdfs:label "chem16 venous blood alanine aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100016 .

obo:OBI_0200050 a rdfs:Class ;
  rdfs:label "dimensionality reduction"@en ;
  rdfs:comment "A dimensionality reduction is data partitioning which transforms each input m-dimensional vector (x_1, x_2, ..., x_m) into an output n-dimensional vector (y_1, y_2, ..., y_n), where n is smaller than m."@en ;
  rdfs:subClassOf obo:OBI_0200175 .

obo:OBI_0000373 a rdfs:Class ;
  rdfs:label "ionize process"@en ;
  rdfs:comment "a physical process of converting an atom or molecule into an ion by adding or removing charged particles such as electrons or other ions. This excludes chemical processes of dissociation."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0001197 a rdfs:Class ;
  rdfs:label "comparative genome hybridization by array design" ;
  rdfs:comment "A study design that detects genomic copy number variations using microarray technology."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001019 a rdfs:Class ;
  rdfs:label "RNA ADA I RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNA adenosine deaminase I as reagent and enzymatic probe."@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:GO_0009636 a rdfs:Class ;
  rdfs:label "response to toxic substance" ;
  rdfs:comment "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." ;
  rdfs:subClassOf obo:GO_0050896 .

obo:OBI_0002438 a rdfs:Class ;
  rdfs:label "nuclear ligation assay" ;
  rdfs:comment "An assay that detects the proximity of chromosomal DNA through the use of a ligation reaction in isolated nuclei."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002075 a rdfs:Class ;
  rdfs:label "MHC ligand assay" ;
  rdfs:comment "An immune epitope assay that characterizes the structrue of a MHC-ligand complex, or detects the processing and presentation of a ligand by an antigen presenting cell, or the binding of a ligand to an MHC molecule."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110128 .

obo:OBI_0000903 a rdfs:Class ;
  rdfs:label "in vitro cell killing assay" ;
  rdfs:comment "A cell killing assay that measures if and how many target cells are actively killed by other cells in a cell culture."@en ;
  rdfs:subClassOf obo:OBI_0000882 , obo:OBI_0003587 .

obo:OBI_0002568 a rdfs:Class ;
  rdfs:label "sequence data feature count tabulation" ;
  rdfs:comment "The counting of features (typically, genes) within aligned sequence data, and organization of these counts into one or more tables."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:UBERON_0002367 a rdfs:Class ;
  rdfs:label "prostate gland" ;
  rdfs:comment "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:PATO_0001296 a rdfs:Class ;
  rdfs:label "luminous flux" ;
  rdfs:comment "A scalar optical quality which obtains by the magnitude of the light emitted by the bearer." ;
  rdfs:subClassOf obo:PATO_0001300 .

obo:OBI_0001701 a rdfs:Class ;
  rdfs:label "antigen inhibition assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope qualitative binding to antibody assay that measures the ability of an antigen to inhibit antibody binding to a known ligand."@en ;
  rdfs:subClassOf obo:OBI_0001703 .

obo:OBI_0400103 a rdfs:Class ;
  rdfs:label "DNA sequencer" ;
  rdfs:comment "A DNA sequencer is an instrument that determines the order of deoxynucleotides in deoxyribonucleic acid sequences."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0000163 a rdfs:Class ;
  rdfs:label "radiolabel role"@en ;
  rdfs:comment "a molecular label role which inheres in a material entity which is realized by the process of radioactivity detection"@en ;
  rdfs:subClassOf obo:OBI_0002743 .

obo:GO_0002507 a rdfs:Class ;
  rdfs:label "tolerance induction" ;
  rdfs:comment "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_2100075 a rdfs:Class ;
  rdfs:label "CBC venous blood WBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of WBCs in venous blood as part of a CBC order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:CHEBI_15377 a rdfs:Class ;
  rdfs:label "water" ;
  rdfs:comment "An oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:CHEBI_61057 a rdfs:Class ;
  rdfs:label "tacrolimus hydrate" ;
  rdfs:comment "A hydrate that is the monohydrate form of tacrolimus." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0302914 a rdfs:Class ;
  rdfs:label "digital curation"@en ;
  rdfs:comment "Digital curation is the process of establishing and developing long term repositories of digital assets for current and future reference by researchers, scientists, and historians, and scholars generally."@en ;
  rdfs:subClassOf obo:IAO_0000572 .

obo:OBI_0003522 a rdfs:Class ;
  rdfs:label "stance feet together assessment" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet together."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0000038 a rdfs:Class ;
  rdfs:label "chromatography column" ;
  rdfs:comment "Chromatography column in chemistry is a tube and contents (typically glass) used to purify individual chemical compounds from mixtures of compounds. It is often used for preparative applications on scales from micrograms up to kilograms."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0001170 a rdfs:Class ;
  rdfs:label "reverse transcription polymerase chain reaction assay" ;
  rdfs:comment "An assay that determines the concentration of RNA in a sample in which an RNA strand is first reverse transcribed into its DNA complement (complementary DNA, or cDNA) using the enzyme reverse transcriptase, and the resulting cDNA is amplified using traditional or real-time PCR."@en ;
  rdfs:subClassOf obo:OBI_0002692 .

obo:OBI_0000444 a rdfs:Class ;
  rdfs:label "target of material addition role"@en ;
  rdfs:comment "A role of a material entity that is realized in an \"adding a material entity into a target\" process where the bearer of the role (the target) receives the addition of another material entity."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001514 a rdfs:Class ;
  rdfs:label "minimal inhibitory concentration" ;
  rdfs:comment "A scalar measurement datum that indicates the lowest concentration at which a specific compound significantly inhibits a process from occurring compared to in the absence of the compound."@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0001276 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects production of chemokine (C-C motif) ligand 1 by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002929 a rdfs:Class ;
  rdfs:label "gravid trap" ;
  rdfs:comment "An arthropod trap that is designed to collect gravid female arthropods or their eggs."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0003691 a rdfs:Class ;
  rdfs:label "liquid nitrogen bath" ;
  rdfs:comment "A temperature control bath in which liquid nitrogen acts as contact medium providing a constant temperature of −195.8 °C at 1 atm."@en ;
  rdfs:subClassOf obo:OBI_0400120 .

obo:OBI_2100177 a rdfs:Class ;
  rdfs:label "quantitative venous blood IgG assay" ;
  rdfs:comment "An assay that measures IgG in venous blood as part of a quantitative order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:IAO_8000005 a rdfs:Class ;
  rdfs:label "import ontology module"@en ;
  rdfs:comment "A subset ontology module that is intended to be imported from another ontology."@en ;
  rdfs:seeAlso <http://robot.obolibrary.org/extract> ;
  rdfs:subClassOf obo:IAO_8000006 .

obo:OBI_0002070 a rdfs:Class ;
  rdfs:label "in vivo assay measuring epitope specific proliferation of T cells" ;
  rdfs:comment "A T cell epitope specific proliferation assay that is performed in vivo."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001484 , obo:OBI_1110131 .

obo:OBI_0001181 a rdfs:Class ;
  rdfs:label "binding datum" ;
  rdfs:comment "A data item that states if two or more material entities have the disposition to form a complex, and if so, how strong that disposition is."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0001738 a rdfs:Class ;
  rdfs:label "X-ray crystallography assay determining the 3D structure of a B cell epitope:antibody complex" ;
  rdfs:comment "A X-ray crystallography 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a B cell epitope:antibody complex."@en ;
  rdfs:subClassOf obo:OBI_0000912 , obo:OBI_0001721 .

obo:IAO_0000003 a rdfs:Class ;
  rdfs:label "measurement unit label"@en ;
  rdfs:comment "A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure."@en ;
  rdfs:subClassOf obo:IAO_0000009 .

obo:OBI_0003421 a rdfs:Class ;
  rdfs:label "antigen specific antibodies in milk assay datum" ;
  rdfs:comment "An antigen specific antibodies assay datum that is the specified output of an antigen specific antibodies in milk assay."@en ;
  rdfs:subClassOf obo:OBI_0003365 , obo:OBI_0003417 .

obo:OBI_0004001 a rdfs:Class ;
  rdfs:label "randomized clinical trial"@en ;
  rdfs:comment "A clinical trial in which the participants are divided by chance into separate groups that compare different treatments or other interventions. Using chance to divide people into groups means that the groups will be similar and that the effects of the treatments they receive can be compared more fairly. At the time of the trial, it is not known which treatment is best."@en ;
  rdfs:subClassOf obo:OBI_0003699 .

obo:OBI_0000501 a rdfs:Class ;
  rdfs:label "variable wavelength detector" ;
  rdfs:comment "A chromatography detector, that can detect signals within a certain range at user-defined wavelengths."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0200061 a rdfs:Class ;
  rdfs:label "data imputation"@en ;
  rdfs:comment "Imputation is a means of filling in missing data values from a predictive distribution of the missing values.  The predictive distribution can be created either based on a formal statistical model (i,e, a multivariate normal distribution) or an algorithm."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_2100122 a rdfs:Class ;
  rdfs:label "T4 uptake venous blood T4 assay" ;
  rdfs:comment "An analyte assay that measures the abundance of T4 in venous blood as part of a T4 uptake order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100035 .

obo:OBI_0003902 a rdfs:Class ;
  rdfs:label "transepithelial / transendothelial electrical resistance (TEER) assay" ;
  rdfs:comment "An extracellular electrophysiology recording assay to measure the integrity of a cell monolayer"@en ;
  rdfs:subClassOf obo:OBI_0000454 , obo:OBI_0001977 .

obo:OBI_2100100 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood WBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of WBCs in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:OBI_0000506 a rdfs:Class ;
  rdfs:label "photoionization detector" ;
  rdfs:comment "The selective determination of aromatic hydrocarbons or organo-heteroatom species is the job of the photoionization detector (PID). This device uses ultraviolet light as a means of ionizing an analyte exiting from a GC column. The ions produced by this process are collected by electrodes. The current generated is therefore a measure of the analyte concentration. f the amount of ionization is reproducible for a given compound, pressure, and light source then the current collected at the PID's reaction cell electrodes is reproducibly proportional to the amount of that compound entering the cell. The reason why the compounds that are routinely analyzed are either aromatic hydrocarbons or heteroatom containing compounds (like organosulfur or organophosphorus species) is because these species have ionization potentials (IP) that are within reach of commercially available UV lamps. The available lamp energies range from 8.3 to 11.7 ev, that is, lambda max ranging from 150 nm to 106 nm. Although most PIDs have only one lamp, lamps in the PID are exchanged depending on the compound selectivity required in the analysis."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_0002626 a rdfs:Class ;
  rdfs:label "RNAi gene knockdown" ;
  rdfs:comment "A gene knockdown that silences genes through artificially-induced RNA interference. This is accomplished by introducing small double-stranded interfering RNA complementary to the target mRNA to be silenced, which is then cleaved by a ribonuclease."@en ;
  rdfs:subClassOf obo:OBI_0002625 .

obo:OBI_0001448 a rdfs:Class ;
  rdfs:label "individual genetic characteristics comparison design" ;
  rdfs:comment "A study design where genotype, haplotype, or other individual genetic characteristics are compared."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001591 a rdfs:Class ;
  rdfs:label "direct binding assay" ;
  rdfs:comment "A binding assay that measures the formation or disassociation of a complex of 2 material entities directly without use of a competitve ligand."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0003151 a rdfs:Class ;
  rdfs:label "chloride concentration assay" ;
  rdfs:comment "A chloride assay that measures the concentration of chloride in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100010 .

obo:OBI_0002983 a rdfs:Class ;
  rdfs:label "altitude measurement datum" ;
  rdfs:comment "A length measurement datum between a point at sea or ground level and some point above it."@en ;
  rdfs:subClassOf obo:IAO_0000408 .

obo:GO_0006955 a rdfs:Class ;
  rdfs:label "immune response" ;
  rdfs:comment "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." ;
  rdfs:subClassOf obo:GO_0050896 .

obo:OBI_0003562 a rdfs:Class ;
  rdfs:label "intracerebral administration" ;
  rdfs:comment "An administration of a substance into the cerebrum of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0002470 a rdfs:Class ;
  rdfs:label "bcl2fastq software application"@en ;
  rdfs:comment "A base calling application that implments a base calling algorithm to convert BCL (binary base call) files generated by Illumina sequencing systems to standard FASTQ file formats for downstream analysis."@en ;
  rdfs:subClassOf obo:OBI_0002469 .

obo:NCBITaxon_3052230 a rdfs:Class ;
  rdfs:label "Hepacivirus hominis" ;
  rdfs:subClassOf obo:NCBITaxon_11050 .

obo:OBI_0003814 a rdfs:Class ;
  rdfs:label "organism development assay in late embryo based on examination of skeletal system" ;
  rdfs:comment "An organism development assay in late embryo that evaluates the skeletal system of the organism"@en ;
  rdfs:subClassOf obo:OBI_0003767 .

obo:OBI_0302886 a rdfs:Class ;
  rdfs:label "centrifugation"@en ;
  rdfs:comment "centrifugation is a process separating molecules by size or density using centrifugal forces generated by a spinning rotor. G-forces of several hundred thousand times gravity are generated in ultracentrifugation"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_1110037 a rdfs:Class ;
  rdfs:label "assay measuring binding of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A T cell epitope assay that measures the binding of T cell receptor to an epitope."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003128 .

obo:OBI_0000748 a rdfs:Class ;
  rdfs:label "bisulfite sequencing assay" ;
  rdfs:comment "A DNA methylation profiling assay which determines the methylation status of genomic DNA using DNA sequencing techniques preceded by a bisulfite based chemical modification of genomic DNA at CpG island location."@en ;
  rdfs:subClassOf obo:OBI_0000626 , obo:OBI_0000634 .

obo:OBI_0200141 a rdfs:Class ;
  rdfs:label "log base"@en ;
  rdfs:comment "The log base is a feature of a logarithmic function which is defined in http://en.wikipedia.org/wiki/Logarithm. Its value can be any positive real number different from 1."@en ;
  rdfs:subClassOf obo:OBI_0200140 .

obo:OBI_0003218 a rdfs:Class ;
  rdfs:label "bile salt assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bile salt"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001063 a rdfs:Class ;
  rdfs:label "automatic staining machine" ;
  rdfs:comment "A device that is used to automatically stain tissue sections on slides or tissue specimens."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:UBERON_0002469 a rdfs:Class ;
  rdfs:label "esophagus mucosa" ;
  rdfs:comment "A mucosa that is part of a esophagus [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_2000011 a rdfs:Class ;
  rdfs:label "meconium specimen" ;
  rdfs:comment "A specimen that is derived from some meconium"@en ;
  rdfs:subClassOf obo:OBI_0002503 .

obo:CL_0000771 a rdfs:Class ;
  rdfs:label "eosinophil" ;
  rdfs:comment "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." ;
  rdfs:subClassOf obo:CL_0000081 , obo:CL_0000738 .

obo:PATO_0001574 a rdfs:Class ;
  rdfs:label "flow rate" ;
  rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's motion characteristic." ;
  rdfs:subClassOf obo:PATO_0001906 .

obo:OBI_0000914 a rdfs:Class ;
  rdfs:label "nasopharyngeal aspirate specimen" ;
  rdfs:comment "A specimen which derives from nasopharyngeal mucosa after aspiration."@en ;
  rdfs:subClassOf obo:OBI_2000007 .

obo:OBI_2100256 a rdfs:Class ;
  rdfs:label "POC chem8 arterial blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in arterial blood as part of a POC chem8 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:IAO_0000109 a rdfs:Class ;
  rdfs:label "measurement datum"@en ;
  rdfs:comment "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0003770 a rdfs:Class ;
  rdfs:label "neurite length assay" ;
  rdfs:comment "A cytometry assay that uses a distance measurement assay to determine the length of a neurite."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0001473 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection after tumor burden challenge" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from tumor challenge using tumor burden."@en ;
  rdfs:subClassOf obo:OBI_0003458 , obo:OBI_0003461 .

obo:OBI_0001318 a rdfs:Class ;
  rdfs:label "proteomic profiling by array assay" ;
  rdfs:comment "An assay that detects proteins in a sample (quantified or otherwise analyzed), e.g. antibody profiling using an array based technology."@en ;
  rdfs:subClassOf obo:OBI_0001985 , obo:OBI_2100023 .

obo:OBI_0003454 a rdfs:Class ;
  rdfs:label "Mosquito Magnet Liberty Plus trap" ;
  rdfs:comment "An arthropod trap that is designed to emit a combination of carbon dioxide, heat, water, and oct-1-en-3-ol attractants while simultaneously using suction to trap arthropods. This trap has the same design as the Mosquito Magnet Pro trap but is smaller, is more lightweight, and uses a main line electricity supply instead of propane to power itself. Both use propane to produce the arthropod attractor."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:GO_0042446 a rdfs:Class ;
  rdfs:label "hormone biosynthetic process" ;
  rdfs:comment "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0000091 a rdfs:Class ;
  rdfs:label "detector reagent role"@en ;
  rdfs:comment "a role which inheres in a molecular entity and is realized by the process of recording or registering a stimulus."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003569 a rdfs:Class ;
  rdfs:label "intrauteral administration" ;
  rdfs:comment "An adminstration of a substance into the uterus of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0003192 a rdfs:Class ;
  rdfs:label "adiponectin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of adiponectin"@en ;
  rdfs:subClassOf obo:OBI_2100023 .

obo:OBI_0003253 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a cerebrospinal fluid microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 , obo:OBI_0003252 .

obo:OBI_1110167 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-4 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001450 , obo:OBI_0600031 .

obo:OBI_0002752 a rdfs:Class ;
  rdfs:label "Oxford Nanopore PromethION" ;
  rdfs:comment "A DNA sequencer that is manufactured by the Oxford Nanopore Technologies corporation, capable of running up to 48 flow cells and producing up to 7.6 Tb of data per run. The sequencer produces real-time results and utilizes Nanopore technology, with each flow cell allowing up to 3,000 nanopores to be sequencing simultaneously."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0600023 a rdfs:Class ;
  rdfs:label "non specific enzymatic cleavage"@en ;
  rdfs:comment "an enzymatic cleavage that uses an enzyme without a strong affinity for specific cleavage sites in the input material"@en ;
  rdfs:subClassOf obo:OBI_0000231 .

obo:OBI_0000949 a rdfs:Class ;
  rdfs:label "accessed material role" ;
  rdfs:comment "is realized in a planned process where the bearer participates"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002911 a rdfs:Class ;
  rdfs:label "arthropod resting outdoors specimen collection by aspiration" ;
  rdfs:comment "An animal-biting arthropod specimen collection by aspiration that occurs while the arthropod is resting outside a building during a period of inactivity."@en ;
  rdfs:subClassOf obo:OBI_0002905 .

obo:OBI_0002128 a rdfs:Class ;
  rdfs:label "Illumina Genome Analyzer" ;
  rdfs:comment "A DNA sequencer manufactured by Solexa as one of its first sequencer lines, launched in 2006, and capable of sequencing 1 gigabase (Gb) of data in a single run."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0000389 a rdfs:Class ;
  rdfs:label "isoelectric focusing device" ;
  rdfs:comment "An isoelectric focusing device is a device in which isoelectric focusing can be performed. An isoelectric focussing device had the function to contain and control the contained environment and transfer electrical energy from a power supply to a separation medium and the charged material to be separated."@en ;
  rdfs:subClassOf obo:OBI_0002089 .

obo:OBI_0000574 a rdfs:Class ;
  rdfs:label "high temperature column" ;
  rdfs:comment "A high temperature column is a chromatography column which is suitable for and withstands very high temperatures in chromatography ovens."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0600019 a rdfs:Class ;
  rdfs:label "non-specific labeling"@en ;
  rdfs:comment "The addition of a reagent labeling the entire input biomaterial enabling future detection of the output biomaterial"@en ;
  rdfs:subClassOf obo:OBI_0600038 .

obo:OBI_0000874 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acid polymers with complementary probes" ;
  rdfs:comment "An analyte assay in which a specified input material (the evaluant) is examined for the presence or quantity of specified nucleic acid polymers, which are identified based on the use of complementary nucleic acid probes."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000642 a rdfs:Class ;
  rdfs:label "atomic emission detector" ;
  rdfs:comment "Instead of measuring simple gas phase (carbon containing) ions created in a flame as with the flame ionization detector, or the change in background current because of electronegative element capture of thermal electrons as with the electron capture detector, the AED has a much wider applicability because it is based on the detection of atomic emissions. The strength of the AED lies in the detector's ability to simultaneously determine the atomic emissions of many of the elements in analytes that elute from a GC capillary column (called eluants or solutes in some books). As eluants come off the capillary column they are fed into a microwave powered plasma (or discharge) cavity where the compounds are destroyed and their atoms are excited by the energy of the plasma. The light that is emitted by the excited particles is separated into individual lines via a photodiode array. The associated computer then sorts out the individual emission lines and can produce chromatograms made up of peaks from eluants that contain only a specific element."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_0600004 a rdfs:Class ;
  rdfs:label "human subject enrollment"@en ;
  rdfs:comment "A planned process with the objective to obtain a population of human subjects to participate in an investigation by determining eligibility of subjects and obtaining informed consent."@en ;
  rdfs:subClassOf obo:OBI_0001928 .

obo:OBI_0400025 a rdfs:Class ;
  rdfs:label "CyFlow SL3" ;
  rdfs:comment "A CyFlow_Sl3 is a flow_cytometer_analyser manufactured by Partec. Its specs are: ultracompact and fully equipped mobile/portable instrument, dimensions [cm]: L 43 x H 16 x D 37 , highest stability/robustness and highest precision, 5 optical parameters: FSC, SSC, FL-1, FL-2, FL-3, 20mW@488nm blue solid state laser, other laser light sources optional (UV, violet, green, red), WindowsTM XP FloMax (software for real time data acquisition, data display, and data evaluation), parallel 16 bit digital pulse processing. The CyFlow SL3 is a compact and dedicated portable Flow Cytometer for accurate and affordable cell analysis and true volumetric absolute counting in HIV Monitoring and AIDS patient follow-up by precise and direct CD4 and CD4% measurement."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0200189 a rdfs:Class ;
  rdfs:label "merging objective"@en ;
  rdfs:comment "A merging objective is a data transformation objective in which the data transformation has the aim of performing a union of two or more sets."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0001105 a rdfs:Class ;
  rdfs:label "scanning force microscope" ;
  rdfs:comment "A microscope that forms images of surfaces using a physical probe that scans the specimen."@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:OBI_0000205 a rdfs:Class ;
  rdfs:label "obsolete_dropout role" ;
  rdfs:comment "Dropout is a study subject role borne by an entity realized by a process of leaving the study earlier than the protocol specified and where the bearer of the dropout role had been borne study subject role prior to bearing dropout role."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003821 a rdfs:Class ;
  rdfs:label "oligodendrocyte migration assay" ;
  rdfs:comment "A cell migration assay that measures migration of an oligodendrocyte"@en ;
  rdfs:subClassOf obo:OBI_0003820 .

obo:OBI_0003140 a rdfs:Class ;
  rdfs:label "transposon-induced mutagenesis" ;
  rdfs:comment "A random mutagenesis in which expression of a transposase causes the mobilization of an artificial or modified transposable element with the insertion of the element into the genome creating a mutation."@en ;
  rdfs:subClassOf obo:OBI_0002620 .

obo:OBI_0003897 a rdfs:Class ;
  rdfs:label "cell count assay" ;
  rdfs:comment "An assay that measures the number of cells in a portion of a cell culture or tissue or bodily fluid"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:UBERON_0000463 a rdfs:Class ;
  rdfs:label "organism substance" ;
  rdfs:comment "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." ;
  rdfs:subClassOf obo:UBERON_0000465 .

obo:OBI_1110153 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-4 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001450 .

obo:OBI_0001256 a rdfs:Class ;
  rdfs:label "epitope specific lymphotoxin A production by T cells" ;
  rdfs:comment "A process of lymphotoxin A production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032641 , obo:OBI_0001351 .

obo:OBI_0002690 a rdfs:Class ;
  rdfs:label "insecticide resistance detection objective" ;
  rdfs:comment "An organism feature identification objective that aims to detect insecticide resistance of an insect."@en ;
  rdfs:subClassOf obo:OBI_0000268 .

obo:OBI_0200059 a rdfs:Class ;
  rdfs:label "mhc binding prediction"@en ;
  rdfs:comment "An MHC binding prediction takes an input of a biomaterial sequence and through an analysis of this sequence, produces as output a prediction of the likelihood that the biomaterial will bind to an MHC molecule."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_2100401 a rdfs:Class ;
  rdfs:label "lipid panel reflex direct venous blood high density lipoprotein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of high density lipoprotein in venous blood as part of a Lipid panel reflex direct order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100030 .

obo:OBI_0003417 a rdfs:Class ;
  rdfs:label "antigen specific antibodies assay datum" ;
  rdfs:comment "A data entity that is the specified output of an antigen specific antibodies assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_2100169 a rdfs:Class ;
  rdfs:label "blood gas venous blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in venous blood as part of a blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:PATO_0001340 a rdfs:Class ;
  rdfs:label "hermaphrodite" ;
  rdfs:comment "A biological sex quality inhering in an organism or a population with both male and female sexual organs in one individual." ;
  rdfs:subClassOf obo:PATO_0001894 .

obo:OBI_0400081 a rdfs:Class ;
  rdfs:label "particle delivery vessel"@en ;
  rdfs:comment "Part of the fluidics subsystem. A particle delivery vessel is used to introduce either a single sample or multiple samples to a flow cytometer. The most common particle delivery vessel is a sample tube."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:COB_0000077 a rdfs:Class ;
  rdfs:label "obsolete action specification" .

obo:OBI_0003264 a rdfs:Class ;
  rdfs:label "bacteria in feces datum" ;
  rdfs:comment "A feces microbiology datum that is about bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003246 .

obo:MRO_0001622 a rdfs:Class ;
  rdfs:label "HLA protein complex with DQ3 serotype" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:OBI_0002402 a rdfs:Class ;
  rdfs:label "hormonal birth control former use history" ;
  rdfs:comment "A hormonal birth control use history that indicates an individual has previously been a hormonal birth control user but is not a current user."@en ;
  rdfs:subClassOf obo:OBI_0002401 .

obo:OBI_0003296 a rdfs:Class ;
  rdfs:label "antibodies from lymphocyte secretions assay" ;
  rdfs:comment "An assay that evaluates a blood specimen for antibodies currently being produced by lymphocytes in the specimen, by separating peripheral blood mononuclear cells, culturing them, and then collecting the supernatant containing the antibodies secreted from those cells."@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0001142 a rdfs:Class ;
  rdfs:label "dye swap quality control role"@en ;
  rdfs:comment "a reference substance role that is borne by a material entity used in a dye swap design experiment for quality control or data normalization purposes"@en ;
  rdfs:subClassOf obo:OBI_0000025 .

obo:OBI_0002391 a rdfs:Class ;
  rdfs:label "exposure to second hand smoke in household during childhood" ;
  rdfs:comment "An exposure to second hand smoke that occurred in the (patient's) household when the person was a child."@en ;
  rdfs:subClassOf obo:OBI_0002390 .

obo:OBI_2100251 a rdfs:Class ;
  rdfs:label "POC chem8 arterial blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a POC chem8 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0000339 a rdfs:Class ;
  rdfs:label "planning"@en ;
  rdfs:comment "a process of creating or modifying a plan specification"@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBI_0400055 a rdfs:Class ;
  rdfs:label "inFlux Analyzer" ;
  rdfs:comment "The inFlux Analyzer is a flow_cytometer_analyser manufactured by Cytopeia. It is a digital machine, with these laser options: Coherent 70, 90, 300 series water cooled lasers, solid state UV 355nm, Violet 408nm, Violet-Blue 479nm, Blue-488nm, Green-531nm, Red-635nm, Red-647nm. Filters and PMTs are used for all parameters (including forward light scatter), and up to 12 PMTs can be included. The Influx analyser can be used to measure the properties of individual cells."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0001141 a rdfs:Class ;
  rdfs:label "individual organism identifier"@en ;
  rdfs:comment "a CRID symbol used to distinguish one individual organism from another."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0200144 a rdfs:Class ;
  rdfs:label "subgraph out-degree calculation"@en ;
  rdfs:comment "A network subgraph quality calculation in which an input data set describing subgraphs and relationship edges between subgraphs and other network objects is used to enumerate the number of unique relationships pointing out of an individual subgraph."@en ;
  rdfs:subClassOf obo:OBI_0200137 .

obo:OBI_0002922 a rdfs:Class ;
  rdfs:label "baited net trap" ;
  rdfs:comment "An arthropod trap designed to work with an animal (which could be human) inside a netted structure. This structure is designed so that an arthropod, attracted by the animal, can fly into the netted structure but can neither escape nor reach the animal."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0000653 a rdfs:Class ;
  rdfs:label "fuzzy clustering objective"@en ;
  rdfs:comment "A fuzzy clustering objective is a data transformation objective where the aim is to assign input objects (typically vectors of attributes) a probability that a point belongs to a class, where the number of class and their specifications are not known a priori."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0003051 a rdfs:Class ;
  rdfs:label "egg specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process in which the arthropods are in the embryo stage."@en ;
  rdfs:subClassOf obo:OBI_0002907 .

obo:OBI_0000732 a rdfs:Class ;
  rdfs:label "restriction enzyme" ;
  rdfs:comment "an enzyme that has a specific target cleavage sites within nucleic acids"@en ;
  rdfs:subClassOf obo:PR_000000001 .

obo:RO_0000056 a rdf:Property ;
  rdfs:label "participates in"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0200138 a rdfs:Class ;
  rdfs:label "subgraph degree calculation"@en ;
  rdfs:comment "A network subgraph quality calculation in which an input data set describing subgraphs and relationship edges between subgraphs and other network objects is used to enumerate the number of unique relationships of an individual subgraph."@en ;
  rdfs:subClassOf obo:OBI_0200137 .

obo:OBI_0003511 a rdfs:Class ;
  rdfs:label "heel along shin assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to slide their heel back and forth along their contralateral tibia from the patella to the ankle with the contralateral leg extended."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0001023 a rdfs:Class ;
  rdfs:label "Fe-BABE RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic secondary structure at a nucleotide resolution scale using Fe-BABE as reagent and chemical probe."@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_1110207 a rdfs:Class ;
  rdfs:label "assay detecting IFN-gamma production" ;
  rdfs:comment "An assay that determines information about the production of the cytokine interferon gamma"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001078 a rdfs:Class ;
  rdfs:label "infrared image acquisition device" ;
  rdfs:comment "An image acquisition device that is responsive to an infrared emissive target within a given field of view."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:PATO_0001377 a rdfs:Class ;
  rdfs:label "polyploid" ;
  rdfs:comment "A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes." ;
  rdfs:subClassOf obo:PATO_0001393 .

obo:GO_0016491 a rdfs:Class ;
  rdfs:label "oxidoreductase activity" ;
  rdfs:comment "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0001008 a rdfs:Class ;
  rdfs:label "MPE-Fe(II) structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using Fe-MP as reagent and chemical probe."@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001395 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-23 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-23 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001363 .

obo:SO_0000276 a rdfs:Class ;
  rdfs:label "miRNA" ;
  rdfs:comment "Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes). Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:OBI_0003112 a rdfs:Class ;
  rdfs:label "Olink assay" ;
  rdfs:comment "A proximity extension assay that uses quantitative polymerase chain reaction (qPCR) technology to determine the concentration/presence of proteins using a high-multiplex, high-throughput protein biomarker platform. The assay utilizes two distinct oligonucleotide-labeled antibodies (‘probes’) that bind at different sites for each detected protein. When the two probes are in close proximity, a new PCR target sequence is formed by a proximity-dependent DNA polymerization event. The resulting sequence is subsequently detected and quantified using standard real-time PCR."@en ;
  rdfs:subClassOf obo:OBI_0003113 .

obo:CHEBI_23528 a rdfs:Class ;
  rdfs:label "cytochalasin" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003913 a rdfs:Class ;
  rdfs:label "single-cell metabolically labeled new RNA tagging sequencing" ;
  rdfs:comment "A single-cell transcription profiling by RNA sequencing assay in which mRNA transcripts are metabolically labeled with 4-thiouridine to investigate temporal RNA dynamics."@en ;
  rdfs:subClassOf obo:OBI_0002631 .

obo:CHEBI_33359 a rdfs:Class ;
  rdfs:label "rhodium atom" ;
  rdfs:comment "A cobalt group element atom of atomic number 45." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003601 a rdfs:Class ;
  rdfs:label "quartz crystal microbalance assay" ;
  rdfs:comment "An assay that measures the change in frequency of a quartz crystal resonator resulting from the addition or removal of a small mass of a ligand specifically binding at the surface of the resonator."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0004035 a rdfs:Class ;
  rdfs:label "alkaline phosphatase activity" ;
  rdfs:comment "Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0002481 a rdfs:Class ;
  rdfs:label "single-end library"@en ;
  rdfs:comment "A cDNA library that is a collection of short tags from only one end of DNA fragments."@en ;
  rdfs:subClassOf obo:OBI_0002754 .

obo:OBI_0001690 a rdfs:Class ;
  rdfs:label "molecular function identification objective"@en ;
  rdfs:comment "is an objective specification which aims to discover molecular function realized by a molecular entity"@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:UBERON_0002199 a rdfs:Class ;
  rdfs:label "integument" ;
  rdfs:comment "The dermis, epidermis and hypodermis." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0002396 a rdfs:Class ;
  rdfs:label "age when gave birth to first child" ;
  rdfs:comment "An age measurement datum performed on a female when her first biological child was born."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:MRO_0000013 a rdfs:Class ;
  rdfs:label "HLA-DR protein complex" ;
  rdfs:subClassOf obo:MRO_0001455 .

obo:PR_000023089 a rdfs:Class ;
  rdfs:label "DNA ligase" ;
  rdfs:comment "A protein that is a translation product of the Escherichia coli K-12 ligA gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:OBI_0000427 , obo:PR_000000001 .

obo:NCBITaxon_7157 a rdfs:Class ;
  rdfs:label "Culicidae" ;
  rdfs:subClassOf obo:NCBITaxon_7147 .

obo:OBI_0002380 a rdfs:Class ;
  rdfs:label "uncle clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male sibling of a parent."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0500008 a rdfs:Class ;
  rdfs:label "balanced incomplete block design" ;
  rdfs:comment "balanced incomplete block design is a kind of factorial design where all treatment pairs occur together within a block an equal number ?? times. ??ii' is the number of times treatment i occurs with i'"@en ;
  rdfs:subClassOf obo:OBI_0500014 .

obo:OBI_0002972 a rdfs:Class ;
  rdfs:label "endotracheal aspirate specimen" ;
  rdfs:comment "A specimen that derives from a biofilm that forms on the inner surface of an endotracheal tube while the tube is in the trachea. The specimen is collected by suction without removing the tube."@en ;
  rdfs:subClassOf obo:OBI_0002781 .

obo:OBI_0003234 a rdfs:Class ;
  rdfs:label "induced sputum assay" ;
  rdfs:comment "An assay that has an induced sputum specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002002 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 2500" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation, with two flow cells and a throughput of up to 160 Gb per day. Built upon sequencing by synthesis technology, the machine is optimized for generation of data for batching multiple samples or rapid results on a few samples."@en ;
  rdfs:subClassOf obo:OBI_0003683 .

obo:OBI_0003639 a rdfs:Class ;
  rdfs:label "antibody purification of HLA-DP protein complex" ;
  rdfs:comment "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DP protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003638 .

obo:OBI_0001610 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific intracellular cytokine staining (ICS) IL-23 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-23 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001363 , obo:OBI_0003115 .

obo:OBI_0001047 a rdfs:Class ;
  rdfs:label "pH meter" ;
  rdfs:comment "A device that is used to measure the pH (acidity or alkalinity) of a liquid."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0003909 a rdfs:Class ;
  rdfs:label "bile acid concentration assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bile acid in a volume of sample."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:MRO_0001435 a rdfs:Class ;
  rdfs:label "cattle MHC class II protein complex" ;
  rdfs:subClassOf obo:MRO_0001356 .

obo:OBI_0003040 a rdfs:Class ;
  rdfs:label "blood assay" ;
  rdfs:comment "An assay that has a blood specimen as evaulant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:FOODON_00002403 a rdfs:Class ;
  rdfs:label "food material"@en ;
  rdfs:comment "Any substance that can be consumed by an organism to satisfy nutritional or other health needs, or to provide a social or organoleptic food experience"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000806 a rdfs:Class ;
  rdfs:label "material maintenance objective" ;
  rdfs:comment "An objective specification maintains some or all of the qualities of a material over time."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0003256 a rdfs:Class ;
  rdfs:label "lung microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a lung microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 .

obo:OBI_0100065 a rdfs:Class ;
  rdfs:label "synthetic peptide"@en ;
  rdfs:comment "a synthetic peptide is an material entity which is artificially engineered and results from the synthesis of a chain of amino acids which may also be found in natural protein and be identical in sequence to a protein fragment"@en ;
  rdfs:subClassOf obo:CHEBI_16670 .

obo:OBI_0001239 a rdfs:Class ;
  rdfs:label "transcription profiling by high throughput sequencing design" ;
  rdfs:comment "A study design in which sequencing technology (e.g. Solexa/454) is used to generate RNA sequence, analyse the transcibed regions of the genome, and/or to quantitate transcript abundance"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:CHEBI_26710 a rdfs:Class ;
  rdfs:label "sodium chloride" ;
  rdfs:comment "An inorganic chloride salt having sodium(1+) as the counterion." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2100190 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0003457 a rdfs:Class ;
  rdfs:label "epitope protection from infectious challenge experiment based on survival" ;
  rdfs:comment "An epitope protection from infectious challenge experiment that determines the success of the epitope intervention based on increased survival of the host compared to controls."@en ;
  rdfs:subClassOf obo:OBI_0001179 .

obo:OBI_0003537 a rdfs:Class ;
  rdfs:label "deep tendon reflex assessment of the ankle joint" ;
  rdfs:comment "A deep tendon reflex assessment of an individual's reaction to stimulus applied to an ankle joint."@en ;
  rdfs:subClassOf obo:OBI_0003517 .

obo:CHEBI_28774 a rdfs:Class ;
  rdfs:label "3,3',5'-triiodothyronine" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001488 a rdfs:Class ;
  rdfs:label "epitope tolerance induction experiment" ;
  rdfs:comment "An efficacy of epitope intervention experiment that tests the ability of the intervention to decrease an existing immune response"@en ;
  rdfs:subClassOf obo:OBI_0001178 .

obo:OBI_0001284 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-12 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001391 , obo:OBI_0003115 .

obo:OBI_0003147 a rdfs:Class ;
  rdfs:label "assay measuring quantitative binding of an epitope:MHC:TCR complex" ;
  rdfs:comment "An assay that detects the binding of a MHC:epitope complex with a T cell receptor, and produces a quantitative measurement of the binding as an output."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110037 .

obo:OBI_0003431 a rdfs:Class ;
  rdfs:label "glutamate dehydrogenase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of glutamate dehydrogenase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0002559 a rdfs:Class ;
  rdfs:label "hospital patient inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion defines that a human being has to be a hospital patient to be suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0001916 a rdfs:Class ;
  rdfs:label "DNA replication identification objective"@en ;
  rdfs:comment "A molecular feature identification objective that aims to examine charateristics of DNA replication, such as replication time."@en ;
  rdfs:subClassOf obo:OBI_0000131 .

obo:OBI_0001439 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ;
  rdfs:comment "A process of chemokine (C-X-C motif) ligand 9 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0035393 , obo:OBI_0001193 .

obo:OBI_1110092 a rdfs:Class ;
  rdfs:label "adjuvant role"@en ;
  rdfs:comment "Adjuvant role is a role that inheres in a material entity and which is realized through a process of modifying a biological response."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001053 a rdfs:Class ;
  rdfs:label "electrophoresis system" ;
  rdfs:comment "A device that moves charged particles through a medium by using an electric field induced by electrodes."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0002018 a rdfs:Class ;
  rdfs:label "transcription factor binding site identification by ChIP-chip assay" ;
  rdfs:comment "A transcription factor binding site assay that utilizes ChIP-chip technology."@en ;
  rdfs:subClassOf obo:OBI_0000291 , obo:OBI_0001248 .

obo:OBI_0001155 a rdfs:Class ;
  rdfs:label "3D structural organization datum" ;
  rdfs:comment "A measurement datum that describes the structural orientation of a material entity in 3D space."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0002173 a rdfs:Class ;
  rdfs:label "Southwestern blot assay" ;
  rdfs:comment "A direct binding assay that detects interactions of labeled DNA with immobilized protein on a membrane."@en ;
  rdfs:subClassOf obo:OBI_0001591 .

obo:OBI_0001833 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-17A production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-17A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001354 , obo:OBI_0001773 , obo:OBI_0600031 .

obo:OBI_0001635 a rdfs:Class ;
  rdfs:label "antibody binding detection by fluorescence quenching" ;
  rdfs:comment "A binding assay in which affinity is measured by detecting a change in fluorescence (usually quenching) that occurs upon binding of the antibody to the ligand. The fluorescent signal that is affected by binding is either from an exogenous fluorophore attached to the ligand, or is the intrisic fluorescence of aromatic (tryptophan) residues on the binding site of the antibody (no conjugated fluorophore necessary) or, less commonly, on the ligand binding region (epitope)."@en ;
  rdfs:subClassOf obo:OBI_0001979 .

obo:OBI_0000731 a rdfs:Class ;
  rdfs:label "recombinant vector" ;
  rdfs:comment "A recombinant vector is created by a recombinant vector cloning process, and contains nucleic acids that can be amplified. It retains functions of the original cloning vector."@en ;
  rdfs:subClassOf obo:BFO_0000040 , obo:COB_0000026 .

obo:OBI_0001263 a rdfs:Class ;
  rdfs:label "in vivo assay measuring epitope specific helper T cell enhancement of a T cell mediated immune response" ;
  rdfs:comment "A T cell epitope specific helper activity assay that detects the ability of a T cell epitope to enhance a T cell response."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001495 .

obo:OBI_0003053 a rdfs:Class ;
  rdfs:label "pupal specimen collection process" ;
  rdfs:comment "An arthropod specimen collection process in which the arthropods are in the pupal stage."@en ;
  rdfs:subClassOf obo:OBI_0002907 .

obo:OBI_2100028 a rdfs:Class ;
  rdfs:label "lactate dehydrogenase complex assay" ;
  rdfs:comment "An assay that measures lactate dehydrogenase complex"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:IAO_0000038 a rdfs:Class ;
  rdfs:label "graph"@en ;
  rdfs:comment "A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way."@en ;
  rdfs:subClassOf obo:IAO_0000308 .

obo:GO_0007049 a rdfs:Class ;
  rdfs:label "cell cycle" ;
  rdfs:comment "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_2100068 a rdfs:Class ;
  rdfs:label "liver injury venous blood alanine aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alanine aminotransferase in venous blood as part of a liver injury order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100016 .

obo:OBI_0400086 a rdfs:Class ;
  rdfs:label "plate loader" ;
  rdfs:comment "Part of the fluidics system. A plate loader positions the wells of a multi-well plate under the aspiration tube is a preset order. A plate loader is used for high throughput applications."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0002033 a rdfs:Class ;
  rdfs:label "translation-associated transcript leader sequencing assay" ;
  rdfs:comment "A translation profiling assay that combines transcript leader sequencing with polysome fractionation. TATL-seq works by applying TL-seq across fractions of a polysome gradient, generating TL-specific translational measurements to identify how different transcript leader sequences effect translation."@en ;
  rdfs:subClassOf obo:OBI_0001282 .

obo:OBI_1110175 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-4 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001450 .

obo:PATO_0001345 a rdfs:Class ;
  rdfs:label "h minus" ;
  rdfs:comment "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." ;
  rdfs:subClassOf obo:PATO_0001343 .

obo:GO_0003990 a rdfs:Class ;
  rdfs:label "acetylcholinesterase activity" ;
  rdfs:comment "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0003471 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific pathogen protection from challenge resulting from the adoptive transfer of epitope specific T cells based on survival" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific T cells using survival."@en ;
  rdfs:subClassOf obo:OBI_0003464 , obo:OBI_0003470 .

obo:OBI_0003656 a rdfs:Class ;
  rdfs:label "water filtration"@en ;
  rdfs:comment "A filtration process of water intended to remove or reduce the concentration of particulate matter, such as suspended particles, parasites, bacteria, algae, viruses, and fungi, as well as other undesirable chemical and biological contaminants."@en ;
  rdfs:subClassOf obo:OBI_0302885 .

obo:OBI_0000410 a rdfs:Class ;
  rdfs:label "recombinant plasmid"@en ;
  rdfs:comment "a plasmid in which extraneous DNA has been inserted."@en ;
  rdfs:subClassOf obo:OBI_0000430 , obo:OBI_0000731 .

obo:OBI_0001020 a rdfs:Class ;
  rdfs:label "Lead structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that determines nucleic acid secondary structure at nucleotide resolution scale using lead as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:GO_0032632 a rdfs:Class ;
  rdfs:label "interleukin-3 production" ;
  rdfs:comment "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0001585 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-7 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-7 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001587 , obo:OBI_0003115 .

obo:IDO_0000562 a rdfs:Class ;
  rdfs:label "antibacterial"@en ;
  rdfs:comment "A material entity bearing an antibacterial disposition."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_2100243 a rdfs:Class ;
  rdfs:label "chem16 venous blood phosphate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of phosphate in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100015 .

obo:OBI_0003324 a rdfs:Class ;
  rdfs:label "high throughput multiplexed assay measuring binding of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A T cell epitope assay that measures the binding of T cell receptor to an epitope using a high throughput multiplexed assay."@en ;
  rdfs:subClassOf obo:OBI_1110037 .

obo:OBI_0000075 a rdfs:Class ;
  rdfs:label "diagnosis textual entity"@en ;
  rdfs:comment "diagnosis is an assessment of a disease or injury, its likely prognosis and treatment."@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:OBI_0002107 a rdfs:Class ;
  rdfs:label "bio-layer interferometry assay" ;
  rdfs:comment "A binding assay that detects a shift in the interference pattern reflected from a layer of immobilized material on the biosensor tip to measure binding to- or dissociating from the material on the biosensor."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0001309 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-13 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001251 .

obo:OBI_0002409 a rdfs:Class ;
  rdfs:label "cream delivery form for hormonal replacement therapy" ;
  rdfs:comment "A delivery form for hormonal replacement therapy that is a cream for transdermal administration."@en ;
  rdfs:subClassOf obo:OBI_0002406 .

obo:OBI_2100270 a rdfs:Class ;
  rdfs:label "venous blood cortisol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of cortisol in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:GO_0032602 a rdfs:Class ;
  rdfs:label "chemokine production" ;
  rdfs:comment "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_1110011 a rdfs:Class ;
  rdfs:label "allergic reaction"@en ;
  rdfs:comment "an allergic reaction is an pathologic immune response by an organism to a non-self entity that is normally harmless(the allergen)"@en ;
  rdfs:subClassOf obo:OBI_1110122 .

obo:OBI_1110044 a rdfs:Class ;
  rdfs:label "cultured PBMC cell population"@en ;
  rdfs:comment "A mixed cell population obtained by processing whole blood. The cells are characterized by having a similar density and are largely mononuclear cells (includes T cells, B cells, and other cell types)."@en ;
  rdfs:subClassOf obo:OBI_0001875 .

obo:OBI_0001613 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring half maximal inhibitory concentration [IC50] to determine competitive binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures half maximal inhibitory concentration (IC50) to detect the loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001992 .

obo:IAO_0000102 a rdfs:Class ;
  rdfs:label "data about an ontology part"@en ;
  rdfs:comment "Data about an ontology part is a data item about a part of an ontology, for example a term"@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:UBERON_0008979 a rdfs:Class ;
  rdfs:label "carcass" ;
  rdfs:comment "A body of a multi-cellular organism that is no longer living." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:GO_0032610 a rdfs:Class ;
  rdfs:label "interleukin-1 alpha production" ;
  rdfs:comment "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032612 .

obo:OBI_0000648 a rdfs:Class ;
  rdfs:label "clustered data set"@en ;
  rdfs:comment "A data set that is produced as the output of a class discovery data transformation and consists of a data set with assigned discovered class labels."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0000954 a rdfs:Class ;
  rdfs:label "subcutaneous injection" ;
  rdfs:comment "is the injection of a material entity (bearing the administered substance role) into the hypodermis (bearing the target role) of an organism using a syringe"@en ;
  rdfs:subClassOf obo:OBI_0000426 , obo:OBI_0600007 .

obo:OBI_0000466 a rdfs:Class ;
  rdfs:label "thermal conductivity detector" ;
  rdfs:comment "The most commonly used detector in preparative GC is the thermal conductivity detector (hot wire detector). Even this detector, however, is often too sensitive and has too high a flow impedance. Under such circumstances, the procedure mentioned above must be employed. The eluent from the preparative column is split and a small portion diverted through the detector (sometimes with further dilution with carrier gas to reduce sensitivity)."@en ;
  rdfs:subClassOf obo:OBI_0000637 .

obo:OBI_0001910 a rdfs:Class ;
  rdfs:label "primary cell culture"@en ;
  rdfs:comment "A cell culture comprised of primary cultured cells and the media in which they are being actively propaged or quiescently stored."@en ;
  rdfs:subClassOf obo:OBI_0001876 .

obo:OBI_0003158 a rdfs:Class ;
  rdfs:label "iron concentration assay" ;
  rdfs:comment "An iron assay that measures the concentration of iron cation in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003011 .

obo:OBI_0200041 a rdfs:Class ;
  rdfs:label "k-means clustering"@en ;
  rdfs:comment "A k-means clustering is a data transformation which achieves a class discovery or partitioning objective, which takes as input a collection of objects (represented as points in multidimensional space) and which partitions them into a specified number k of clusters. The algorithm attempts to find the centers of natural clusters in the data. The most common form of the algorithm starts by partitioning the input points into k initial sets, either at random or using some heuristic data. It then calculates the mean point, or centroid, of each set. It constructs a new partition by associating each point with the closest centroid. Then the centroids are recalculated for the new clusters, and the algorithm repeated by alternate applications of these two steps until convergence, which is obtained when the points no longer switch clusters (or alternatively centroids are no longer changed)."@en ;
  rdfs:subClassOf obo:OBI_0200171 , obo:OBI_0200175 .

obo:OBI_0600056 a rdfs:Class ;
  rdfs:label "protease cleavage"@en ;
  rdfs:comment "protease cleavage is an enzymatic cleavage which relies on enzyme with protease activity to act on proteins and produce polypeptides (protein fragments)."@en ;
  rdfs:subClassOf obo:OBI_0000231 .

obo:OBI_0003683 a rdfs:Class ;
  rdfs:label "Illumina HiSeq series instrument" ;
  rdfs:comment "A DNA Sequencer manufactured and/or marketed by Illumina and branded with the word HiSeq."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:IAO_8000004 a rdfs:Class ;
  rdfs:label "bridge ontology module"@en ;
  rdfs:comment "An ontology module that consists entirely of axioms that connect or bridge two distinct ontology modules. For example, the Uberon-to-ZFA bridge module."@en ;
  rdfs:seeAlso <https://github.com/obophenotype/uberon/wiki/inter-anatomy-ontology-bridge-ontologies> ;
  rdfs:subClassOf obo:IAO_8000000 .

obo:OBI_0003919 a rdfs:Class ;
  rdfs:label "geometric image transformation" ;
  rdfs:comment "An image transformation that alters the geometrical structure of images by shifting image pixels from their original positions to new positions, ideally without modifying the original pixel values. Produces a geometrically modified image data set."@en ;
  rdfs:subClassOf obo:OBI_0003917 .

obo:NCBITaxon_388799 a rdfs:Class ;
  rdfs:label "HIV-1 group O" ;
  rdfs:subClassOf obo:NCBITaxon_11676 .

obo:OBI_0001808 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-3 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-3 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001406 .

obo:OBI_0001501 a rdfs:Class ;
  rdfs:label "fluorescence detection assay" ;
  rdfs:comment "An assay in which a material's fluorescence is determined."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003727 a rdfs:Class ;
  rdfs:label "minimum data transformation" ;
  rdfs:comment "A data transformation that has as its output the least value in the input data set."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:MRO_0000992 a rdfs:Class ;
  rdfs:label "H2-Kd protein complex" ;
  rdfs:subClassOf obo:MRO_0001460 .

obo:OBI_0002935 a rdfs:Class ;
  rdfs:label "New Jersey light trap" ;
  rdfs:comment "A light trap that is designed to use motorized suction to trap arthropods in a collection bag once they approach the light attractant."@en ;
  rdfs:subClassOf obo:OBI_0002930 .

obo:OBI_0001252 a rdfs:Class ;
  rdfs:label "array platform variation design" ;
  rdfs:comment "A study design in which the array platform is compared, e.g. Agilent versus Affymetrix."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001943 a rdfs:Class ;
  rdfs:label "software pipeline"@en ;
  rdfs:comment "A plan specification that specifies a chain encoded in software of processing elements (processes, threads, coroutines, etc.), arranged so that the output of each element is the input of the next. Usually some amount of buffering is provided between consecutive elements."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:GO_0071605 a rdfs:Class ;
  rdfs:label "monocyte chemotactic protein-1 production" ;
  rdfs:comment "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0002723 a rdfs:Class ;
  rdfs:label "insecticide resistance by ligase detection reaction-fluorescent microsphere assay" ;
  rdfs:comment "An insecticide resistance by ligase detection reaction assay that uses fluorescently labeled conserved probes in ligase detection reaction."@en ;
  rdfs:subClassOf obo:OBI_0002722 .

obo:OBI_0001799 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-9 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001253 .

obo:CHEBI_81569 a rdfs:Class ;
  rdfs:label "Follicle stimulating hormone" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0400044 a rdfs:Class ;
  rdfs:label "flow cytometer" ;
  rdfs:comment "A flow_cytometer is an instrument for counting, examining and sorting microscopic particles in suspension. It allows simultaneous multiparametric analysis of the physical and/or chemical characteristics of single cells flowing through an optical and/or electronic detection apparatus. A flow cytometer is an instrument that can be used to quantitatively measure the properties of individual cells in a flowing medium."@en ;
  rdfs:subClassOf obo:OBI_0400137 .

obo:OBI_0000515 a rdfs:Class ;
  rdfs:label "chromatofocusing column" ;
  rdfs:comment "A chromatofocusing column is a chromatography column in which a resin is equilibrated at one pH and eluted at a second pH. The use of a weak ion-exchange resin causes a pH gradient to be formed at the solvent front owing to the buffering action of the resin. This pH gradient in turn leads to an ordering of proteins by isoelectric point. Molecules of charge sign opposite the resin bind; those of charge sign like the resin do not bind."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0002429 a rdfs:Class ;
  rdfs:label "blood transfusion exclusion criterion" ;
  rdfs:comment "An exclusion criterion that is defined by whether the specimen donor received a whole blood transfusion within a specified time frame prior to death, which if met, makes a specimen donor unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0002451 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interferon-alpha production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interferon-alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0002452 .

obo:PATO_0000186 a rdfs:Class ;
  rdfs:label "behavioral quality" ;
  rdfs:comment "An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation." ;
  rdfs:subClassOf obo:PATO_0001995 .

obo:OBI_0001906 a rdfs:Class ;
  rdfs:label "cancer cell line" ;
  rdfs:comment "An immortal cell line derived from a transformed cell that was part of a malignant tumor."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0003708 a rdfs:Class ;
  rdfs:label "infrared gas analyzer" ;
  rdfs:comment "A measurement device that measures the concentration of gases in an air sample based on their absorption of infrared radiation."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0002044 a rdfs:Class ;
  rdfs:label "RNA Bind-n-Seq assay" ;
  rdfs:comment "An assay that comprehensively characterizes sequence and structural specificity of RNA binding proteins (RBPs)."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_1000207 a rdfs:Class ;
  rdfs:label "assay bead"@en ;
  rdfs:comment "A globular or round particle of defined physicochemical properties and size which can be exploited as either the primary substance for detection or as a secondary solid platform for the attachment of bioactive molecules."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0001333 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects macrophage inflammatory protein-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001150 a rdfs:Class ;
  rdfs:label "chromosomal substitution"@en ;
  rdfs:comment "A genetic transformation in which all, or part, of a chromosome from a donor replaces that of the recipient. It does not include chromosome recombination. For single gene insertion, use the term 'gene knock in'."@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_0003577 a rdfs:Class ;
  rdfs:label "skin of body microbiology datum" ;
  rdfs:comment "An organism detection datum that is the specified output of a skin of body microbiology assay."@en ;
  rdfs:subClassOf obo:OBI_0003064 .

obo:OBI_0002011 a rdfs:Class ;
  rdfs:label "Human 2.1M Whole-Genome CGH Tiling Array v2.0" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 2.1 million features."@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_0300311 a rdfs:Class ;
  rdfs:label "observation design" ;
  rdfs:comment "observation design is a study design in which subjects are monitored in the absence of any active intervention by experimentalists."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:GO_0005577 a rdfs:Class ;
  rdfs:label "fibrinogen complex" ;
  rdfs:comment "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." ;
  rdfs:subClassOf obo:GO_0032991 .

obo:OBI_2100043 a rdfs:Class ;
  rdfs:label "hydrogencarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hydrogencarbonate"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001343 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific monocyte chemotactic protein-1 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects monocyte chemotactic protein-1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001465 .

obo:OBI_0002118 a rdfs:Class ;
  rdfs:label "exome sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that intends to provide information about the sequence of the protein coding components of a genome (exons)."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:CHEBI_16990 a rdfs:Class ;
  rdfs:label "bilirubin IXalpha" ;
  rdfs:comment "A member of the class of  biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBA_2060186 a rdfs:Class ;
  rdfs:label "peripheral nervous system function" ;
  rdfs:comment "The functionality of a peripheral nervous system." ;
  rdfs:subClassOf obo:OBA_0000001 .

obo:UBERON_0001723 a rdfs:Class ;
  rdfs:label "tongue" ;
  rdfs:comment "A muscular organ in the floor of the mouth." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0000020 a rdfs:Class ;
  rdfs:label "contract research organization role"@en ;
  rdfs:comment "a worker role of carrying out the study according to the protocol document or study plan delivered by the PI, under the control of the study director.  This role cannot make decisions about the study execution"@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:OBI_0100062 a rdfs:Class ;
  rdfs:label "obsolete_cell line" ;
  rdfs:comment "A secondary cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (ie has been successively passaged together in culture)."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0003544 a rdfs:Class ;
  rdfs:label "analytical chromatography measuring Chikungunya IgM antibody" ;
  rdfs:comment "Analytical chromatography that detects the IgM antibody that binds Chikungunya."@en ;
  rdfs:subClassOf obo:OBI_0001630 .

obo:OBI_0003460 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from pathogen challenge" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from pathogen challenge."@en ;
  rdfs:subClassOf obo:OBI_0001179 , obo:OBI_0002073 .

obo:OBI_0002574 a rdfs:Class ;
  rdfs:label "RNA extraction with polyA depletion" ;
  rdfs:comment "A RNA extraction process in which only RNAs lacking a polyA tail are retained"@en ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBI_0001819 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-C motif) ligand 22 production by T cells" ;
  rdfs:comment "A process of chemokine (C-C motif) ligand 22 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071924 , obo:OBI_0001193 .

obo:OBI_0001214 a rdfs:Class ;
  rdfs:label "normalization testing design" ;
  rdfs:comment "A study design that tests different normalization procedures."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001574 a rdfs:Class ;
  rdfs:label "obsolete cell lysate MHC competitive binding assay using radioactivity detection" ;
  rdfs:comment "competitive inhibition of binding assay measuring MHC ligand binding by radioactivity detection using MHC derived from a cell lysate"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:PR_000036195 a rdfs:Class ;
  rdfs:label "bacterial protein" ;
  rdfs:comment "A protein that is encoded in the genome of some Bacteria <prokaryote>." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0000252 a rdfs:Class ;
  rdfs:label "cohort role"@en ;
  rdfs:comment "a cohort role is a biological replicate role played by a group of study participants who share a common characteristic of interest to the study."@en ;
  rdfs:subClassOf obo:OBI_0000198 .

obo:OBI_0400006 a rdfs:Class ;
  rdfs:label "A40-MiniFCM" ;
  rdfs:comment "A A40-MiniFCM is a flow_cytometer_analyser that allows for the choice of one of four lasers (375nm, 405nm,488nm, 532nm, 635nm), and PMTs and filters for collecting up to four parameters. It uses digital electronics. A military version of this cytometer is available as well. The A40-MiniFCM is geared towards the most demanding applications such as archaea, bacteria and large virus."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0003769 a rdfs:Class ;
  rdfs:label "cell death assay using  vital dye" ;
  rdfs:comment "A cell death assay that uses the Trypan blue vital dye to stain cells which have lost membrane integrity."@en ;
  rdfs:subClassOf obo:OBI_0003759 .

obo:OBI_0001183 a rdfs:Class ;
  rdfs:label "epitope protection from tumor challenge experiment" ;
  rdfs:comment "An epitope protection experiment in which the ability of the epitope to protect the host from developing tumors is assessed."@en ;
  rdfs:subClassOf obo:OBI_0001184 .

obo:OBI_0001440 a rdfs:Class ;
  rdfs:label "all pairs design" ;
  rdfs:comment "A study design in which all specimens are compared to every other specimen."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:UBERON_0002385 a rdfs:Class ;
  rdfs:label "muscle tissue" ;
  rdfs:comment "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." ;
  rdfs:subClassOf obo:UBERON_0000479 .

obo:OBI_2100288 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0400014 a rdfs:Class ;
  rdfs:label "BioSorter1000" ;
  rdfs:comment "A BioSorter1000 is a flow_cytometer_sorter manufactured by Union Biometrica. It includes analog electronics, 488/514 nm multi-line Argon-ion laser for fluorescence and a light stabilized 670 nm forward scatter laser for extinction and time-of-flight. It has filters and PMTs for 3 fluorescent parameters and photodiodes for scatter, time of flight, and extinction. The flow cell is quartz cuvette. The BioSorterTM 1000 is an instrument for analyzing and sorting objects from 200-600 microns in diameter."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:GO_0030154 a rdfs:Class ;
  rdfs:label "cell differentiation" ;
  rdfs:comment "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." ;
  rdfs:subClassOf obo:GO_0048869 .

obo:OBI_0002134 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-C motif) ligand 20 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-C motif) ligand 20 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002809 a rdfs:Class ;
  rdfs:label "surgical N95 respirator" ;
  rdfs:comment "A N95 respirator which has been approved by the FDA as a surgical mask."@en ;
  rdfs:subClassOf obo:OBI_0002790 .

obo:OBI_0002928 a rdfs:Class ;
  rdfs:label "encephalitis virus surveillance trap" ;
  rdfs:comment "A light trap that uses carbon dioxide as attractant. The trap consists of a container of dry ice with holes in the bottom to allow the carbon dioxide to flow downward into a separate container, in which a motorized fan creates suction to collect arthropods."@en ;
  rdfs:subClassOf obo:OBI_0002930 .

obo:OBI_0000235 a rdfs:Class ;
  rdfs:label "standard error"@en ;
  rdfs:comment "A quantitative confidence value which is the standard deviations of the sample in a frequency distribution, obtained by dividing the standard deviation by the total number of cases in the frequency distribution."@en ;
  rdfs:subClassOf obo:OBI_0000071 .

obo:OBI_0001101 a rdfs:Class ;
  rdfs:label "electronic repeater pipette" ;
  rdfs:comment "A micropipette that can be programmed by the user to aspirate a volume of liquid reagent or sample and dispense a series of aliquots in successive dispensing operations."@en ;
  rdfs:subClassOf obo:OBI_0001128 .

obo:OGMS_0000063 a rdfs:Class ;
  rdfs:label "disease course" ;
  rdfs:comment "The totality of all processes through which a given disease instance is realized."@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_1110012 a rdfs:Class ;
  rdfs:label "occurrence of allergy"@en ;
  rdfs:comment "The process of an allergic disease occurring in an organism."@en ;
  rdfs:subClassOf obo:OGMS_0000063 .

obo:CHMO_0000102 a rdfs:Class ;
  rdfs:label "light microscopy assay" ;
  rdfs:comment "Microscopy where the specimen is illuminated with visible light and a system of lenses is used to produce an image."@en ;
  rdfs:subClassOf obo:OBI_0002119 .

obo:OBI_0003640 a rdfs:Class ;
  rdfs:label "antibody purification of HLA-DR protein complex" ;
  rdfs:comment "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DR protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003638 .

obo:OBI_0002666 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific induction of hypersensitivity resulting from the adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that detects a hypersensitivity response by monitoring skin reactions after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001178 , obo:OBI_0001694 , obo:OBI_0002677 .

obo:OBI_0003098 a rdfs:Class ;
  rdfs:label "lightsheet fluorescence microscopy assay" ;
  rdfs:comment "A fluorescence microscopy that involves capturing of photons emitted by fluorophores excited with a thin sheet of laser light in a sample only in a relatively narrow plane by a detection objective oriented perpendicularly to the light sheet and imaged onto a detection device such as a CCD camera."@en ;
  rdfs:subClassOf obo:CHMO_0000087 .

obo:OBI_0003243 a rdfs:Class ;
  rdfs:label "blood assay datum" ;
  rdfs:comment "A data entity that is the specified output of a blood assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0100017 a rdfs:Class ;
  rdfs:label "blood serum specimen" ;
  rdfs:comment "A material entity which derives from blood and corresponds to blood plasma without fibrinogen or the other clotting factors."@en ;
  rdfs:subClassOf obo:OBI_0100016 .

obo:OBI_0002087 a rdfs:Class ;
  rdfs:label "containing a specimen function"@en ;
  rdfs:comment "A contain function that involves physical contact with a specimen. This function is typically performed in such a way that the specimen is usable for an investigation or assay."@en ;
  rdfs:subClassOf obo:OBI_0000370 .

obo:OBI_1110059 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interferon-gamma production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interferon-gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001414 , obo:OBI_0600031 .

obo:OBI_0003420 a rdfs:Class ;
  rdfs:label "antigen specific antibodies in blood assay datum" ;
  rdfs:comment "An antigen specific antibodies assay datum that is the specified output of an antigen specific antibodies in blood assay."@en ;
  rdfs:subClassOf obo:OBI_0003243 , obo:OBI_0003417 .

obo:OBI_0002506 a rdfs:Class ;
  rdfs:label "pericardial fluid specimen" ;
  rdfs:comment "A specimen that is derived from pericardial fluid."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_1110106 a rdfs:Class ;
  rdfs:label "cultured antigen presenting cell population" ;
  rdfs:comment "a cell culture including cells that have an antigen presentation function"@en ;
  rdfs:subClassOf obo:OBI_0001875 .

obo:OBI_0302868 a rdfs:Class ;
  rdfs:label "mean-centered data"@en ;
  rdfs:comment "a data item which has been processed by a mean centering data transformation where each output value is produced by subtracting the mean from the inout value"@en ;
  rdfs:subClassOf obo:OBI_0000451 .

obo:OBI_0003139 a rdfs:Class ;
  rdfs:label "targeted mutagenesis" ;
  rdfs:comment "A directed mutation in which a construct is used to introduce a mutation into a specific genome location through homologous recombination."@en ;
  rdfs:subClassOf obo:OBI_0003131 .

obo:OBI_0001054 a rdfs:Class ;
  rdfs:label "PET synthesizer" ;
  rdfs:comment "A device that is used to produce targeted molecular pharmaceuticals for use in positron emission tomography."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:FOODON_00004325 a rdfs:Class ;
  rdfs:label "animal feed" ;
  rdfs:comment "Food material which can be used to meet nutritional requirements of animals, particularly livestock such as cattle, goats, sheep, horses, chickens and pigs." ;
  rdfs:subClassOf obo:FOODON_03309997 .

obo:OBI_0200190 a rdfs:Class ;
  rdfs:label "clustered data visualization" ;
  rdfs:comment "A data visualization which has input of a clustered data set and produces an output of a report graph which is capable of rendering data of this type."@en ;
  rdfs:subClassOf obo:OBI_0200111 .

obo:OBI_0003118 a rdfs:Class ;
  rdfs:label "electron-microscopy 3D molecular structure determination assay" ;
  rdfs:comment "A 3D molecular structure determination assay that uses electron microscopy imaging."@en ;
  rdfs:subClassOf obo:OBI_0003117 .

obo:OBI_0002946 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based apoptosis assay" ;
  rdfs:comment "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures associated with molecular processes of apoptosis."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0003383 a rdfs:Class ;
  rdfs:label "eukaryota in placental blood datum" ;
  rdfs:comment "A placental blood microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003263 , obo:OBI_0003382 .

obo:OBI_0000500 a rdfs:Class ;
  rdfs:label "dual loop autosampler" ;
  rdfs:comment "A dual loop autosampler is an autosampler that is designed for handling both analytical (10 mL/min flow rate) to preparative scale sample purification (100 mL/min flow rate)."@en ;
  rdfs:subClassOf obo:OBI_0000494 .

obo:OBI_0400033 a rdfs:Class ;
  rdfs:label "diode laser" ;
  rdfs:comment "A diode laser is a laser in which the active medium is a p-n junction semiconductor laser diode, similar to that found in a light-emitting diode. Laser diodes emit at wavelengths from 375 nm to 1800 nm, and wavelengths of over 3 micrometer have been demonstrated. A diode laser can by used to irradiate cells in a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400064 .

obo:OBI_0000548 a rdfs:Class ;
  rdfs:label "isolation of PBMCs" ;
  rdfs:comment "a process in which cells with a single nucleus are isolated from a blood sample"@en ;
  rdfs:subClassOf obo:OBI_0000512 .

obo:OBI_0000935 a rdfs:Class ;
  rdfs:label "micromanipulator" ;
  rdfs:comment "A device that is used to physically interact with a sample under a microscope, where a level of precision of movement is necessary that cannot be achieved by the unaided human hand."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001332 a rdfs:Class ;
  rdfs:label "DNA methylation profiling by array assay" ;
  rdfs:comment "A DNA methylation profiling assay in which the methylation state of DNA is determined and can be compared between samples using array technology"@en ;
  rdfs:subClassOf obo:OBI_0000634 .

obo:OBI_0200197 a rdfs:Class ;
  rdfs:label "spectrum analysis objective" ;
  rdfs:comment "is a data transformation objective where the aim is to analyse some aspect of spectral data by some data transformation process."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0001364 a rdfs:Class ;
  rdfs:label "genetic alteration information"@en ;
  rdfs:comment "a genetic characteristics information that is about known changes or the lack thereof from the genetic background, including allele information, duplication, insertion, deletion, etc."@en ;
  rdfs:subClassOf obo:OBI_0001404 .

obo:PATO_0001346 a rdfs:Class ;
  rdfs:label "h plus" ;
  rdfs:comment "A S. pombe mating type determined by the mat1-Pc and mat1-Pi on the mat1 locus." ;
  rdfs:subClassOf obo:PATO_0001343 .

obo:OBI_0000675 a rdfs:Class ;
  rdfs:label "statistical hypothesis test objective"@en ;
  rdfs:comment "is a data transformation objective where the aim is to estimate statistical significance with the aim of proving or disproving a hypothesis by means of some data transformation."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_1110190 a rdfs:Class ;
  rdfs:label "epitope specific IL-12 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-12 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032615 , obo:OBI_0001193 .

obo:OBI_0002092 a rdfs:Class ;
  rdfs:label "3' rapid amplification of cDNA ends"@en ;
  rdfs:comment "A rapid amplication of cDNA ends to amplify a mRNA sequence between a defined internal site and the 3' end of the mRNA."@en ;
  rdfs:subClassOf obo:OBI_0002090 .

obo:OBI_0200186 a rdfs:Class ;
  rdfs:label "error correction objective"@en ;
  rdfs:comment "An error correction objective is a data transformation objective where the aim is to remove (correct for) erroneous contributions arising from the input data, or the transformation itself."@en ;
  rdfs:subClassOf obo:OBI_0200168 .

obo:OBI_0302874 a rdfs:Class ;
  rdfs:label "edited document"@en ;
  rdfs:comment "A document which is the output of a document editing process"@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0400096 a rdfs:Class ;
  rdfs:label "solid state laser" ;
  rdfs:comment "A solid-state laser is a laser that uses a lasing medium that is a solid, rather than a liquid such as dye lasers or a gas such as gas lasers. Semiconductor-based diode lasers are also in the solid state, but are generally considered separately from solid-state lasers. The first laser developed was an optical pumped ruby crystal solid state laser."@en ;
  rdfs:subClassOf obo:OBI_0400064 .

obo:OBI_0001984 a rdfs:Class ;
  rdfs:label "treatment intervention experiment" ;
  rdfs:comment "An in vivo intervention experiment in which the ability of the intervention to reduce or cure the effects of a disease are tested."@en ;
  rdfs:subClassOf obo:OBI_0001980 .

obo:OBI_0002528 a rdfs:Class ;
  rdfs:label "stomach specimen" ;
  rdfs:comment "A specimen that is derived from stomach."@en ;
  rdfs:subClassOf obo:OBI_0003483 .

obo:OBI_0000601 a rdfs:Class ;
  rdfs:label "chromatography consumable" ;
  rdfs:comment "A chromatography consumable is a consumable that is used in a chromatography experiment."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0001122 a rdfs:Class ;
  rdfs:label "diffractometer" ;
  rdfs:comment "A measurement device for analyzing the structure of a material from the scattering pattern produced when a beam of radiation or particles (e.g. X rays or neutrons) interacts with it."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:CL_0011114 a rdfs:Class ;
  rdfs:label "segmented neutrophil of bone marrow" ;
  rdfs:comment "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." ;
  rdfs:subClassOf obo:CL_0000775 .

obo:OBI_0000993 a rdfs:Class ;
  rdfs:label "service provision objective" ;
  rdfs:comment "An objective which is fulfilled by the provision of some service e.g. a training service"@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0001873 a rdfs:Class ;
  rdfs:label "number of errors"@en ;
  rdfs:comment "a data item that is the number of times that a given process failed, as an integer"@en ;
  rdfs:subClassOf obo:IAO_0000027 , obo:OBI_0001933 .

obo:OBI_0003254 a rdfs:Class ;
  rdfs:label "endotracheal aspirate assay datum" ;
  rdfs:comment "An organism detection datum that is the specified output of an endotracheal aspirate assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000816 a rdfs:Class ;
  rdfs:label "micro electrode" ;
  rdfs:comment "An electrode of very fine caliber consisting usually of a fine wire or a glass tube of capillary diameter drawn to a fine point and filled with saline or a metal used in physiological experiments to stimulate or record action currents of extracellular or intracellular origin in the nervous system."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001602 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that detects direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001550 .

obo:OBI_0001106 a rdfs:Class ;
  rdfs:label "pulsed-field gel electrophoresis system" ;
  rdfs:comment "A gel electrophoresis system in which the gel matrix is subjected to an electric field that periodically changes direction."@en ;
  rdfs:subClassOf obo:OBI_0001121 .

obo:OBI_0500013 a rdfs:Class ;
  rdfs:label "hyper graeco latin square design" ;
  rdfs:comment "PRS to do"@en ;
  rdfs:subClassOf obo:OBI_0500007 .

obo:UBERON_0002107 a rdfs:Class ;
  rdfs:label "liver" ;
  rdfs:comment "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:GO_0007596 a rdfs:Class ;
  rdfs:label "blood coagulation" ;
  rdfs:comment "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003774 a rdfs:Class ;
  rdfs:label "cell-body-associated presynaptic puncta count assay" ;
  rdfs:comment "A regulation of synapse maturation assay that determines the number of  synaptic puncta in the cell body compartment of a neuron."@en ;
  rdfs:subClassOf obo:OBI_0003753 .

obo:OBI_0000906 a rdfs:Class ;
  rdfs:label "induced hemagglutination" ;
  rdfs:comment "The clumping or clustering of red blood cells caused by certain viruses, antibodies, or other substances"@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0003655 a rdfs:Class ;
  rdfs:label "fasted"@en ;
  rdfs:comment "An organismal quality that inheres in an organism that has completed a fasting process, and which ceases to inhere in that organism once that organism drinks a liquid other than water or eats."@en ;
  rdfs:subClassOf obo:PATO_0001995 .

obo:OBI_0003357 a rdfs:Class ;
  rdfs:label "brain region atlas image data set" ;
  rdfs:comment "An image data set consisting of values computed from multiple image data sets encoded to represent the spatial location of individual functional or structural regions of a canonical brain."@en ;
  rdfs:subClassOf obo:OBI_0003333 .

obo:OBI_0001794 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific lymphotoxin A production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects lymphotoxin A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001327 , obo:OBI_0001788 .

obo:PR_000029983 a rdfs:Class ;
  rdfs:label "protein-glutamine gamma-glutamyltransferase" ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0001295 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-17 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0400082 a rdfs:Class ;
  rdfs:label "photodetector" ;
  rdfs:comment "A photodetector is a device used to detect and measure the intensity of radiant energy through photoelectric action. In a cytometer, photodetectors measure either the number of photons of laser light scattered on impact with a cell (for example), or the flourescence emitted by excitation of a fluorescent dye."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0002102 a rdfs:Class ;
  rdfs:label "bio-layer interferometry assay measuring the on rate [kon] of a B cell epitope:antibody complex" ;
  rdfs:comment "A bio-layer interferometry assay that measures the on rate of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001718 , obo:OBI_0002107 .

obo:OBI_0003334 a rdfs:Class ;
  rdfs:label "reconstructed magnetic resonance image data set" ;
  rdfs:comment "An image data set that is the direct output of a raw magnetic resonance image data set reconstruction or a transformation of another MR image data set."@en ;
  rdfs:subClassOf obo:OBI_0003328 , obo:OBI_0003333 .

obo:UBERON_0001728 a rdfs:Class ;
  rdfs:label "nasopharynx" ;
  rdfs:comment "The section of the pharynx that lies above the soft palate." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0200044 a rdfs:Class ;
  rdfs:label "complete linkage hierarchical clustering"@en ;
  rdfs:comment "an agglomerative hierarchical clustering which generates successive clusters based on a distance measure, where the distance between two clusters is calculated as the maximum distance between objects from the first cluster and objects from the second cluster."@en ;
  rdfs:subClassOf obo:OBI_0200154 .

obo:OBI_0500024 a rdfs:Class ;
  rdfs:label "standard compliance rule"@en ;
  rdfs:comment "a  standard compliance rule is a compliance rule which defines conformity to a representation standard"@en ;
  rdfs:subClassOf obo:OBI_0500023 .

obo:OBI_0002715 a rdfs:Class ;
  rdfs:label "insecticide resistance dose response by survival of larvae assay" ;
  rdfs:comment "An insecticide resistance dose response assay that tests survival of larvae in a medium supplemented with insecticide."@en ;
  rdfs:subClassOf obo:OBI_0002708 .

obo:OBI_0001399 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-22 production by T cells" ;
  rdfs:comment "A process of interleukin-22 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032626 , obo:OBI_0001193 .

obo:OBI_0001706 a rdfs:Class ;
  rdfs:label "assay measuring biological activity resulting from B cell epitope:antibody binding" ;
  rdfs:comment "A B cell epitope assay that measures the immune response process resulting from the binding of an antibody receptor to epitope or recognition of the epitope."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003127 .

obo:OBI_0000960 a rdfs:Class ;
  rdfs:label "reagent application function" ;
  rdfs:comment "A function that is realized when a reagent is automatically added to some research material."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:UBERON_0000479 a rdfs:Class ;
  rdfs:label "tissue" ;
  rdfs:comment "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:IAO_8000009 a rdfs:Class ;
  rdfs:label "single layer subset ontology module"@en ;
  rdfs:comment "A subset ontology that is largely comprised of a single layer or strata in an ontology class hierarchy. The purpose is typically for rolling up for visualization. The classes in the layer need not be disjoint."@en ;
  rdfs:subClassOf obo:IAO_8000006 .

obo:OBI_0003463 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific survival after tumor challenge" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from tumor challenge using survival."@en ;
  rdfs:subClassOf obo:OBI_0003459 , obo:OBI_0003461 .

obo:OBI_0003068 a rdfs:Class ;
  rdfs:label "clinical study center" ;
  rdfs:comment "Organization that undertakes a clinical study at some point in time."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0000948 a rdfs:Class ;
  rdfs:label "oscilloscope" ;
  rdfs:comment "A device that measures and displayes signal voltages, usually as a two-dimensional graph of one or more electrical potential differences (vertical axis) plotted as a function of time or of some other voltage (horizontal axis)."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001880 a rdfs:Class ;
  rdfs:label "organization of specimen provider principal investigator"@en ;
  rdfs:comment "An organization that is the affiliation of the principal investigator providing the specimens for the investigation"@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0000868 a rdfs:Class ;
  rdfs:label "pattern matching objective" ;
  rdfs:comment "A pattern matching objective aims to detect the presence of the constituents of a given pattern. In contrast to pattern recognition, the pattern is rigidly specified. Patterns are typicall sequences or trees."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0001477 a rdfs:Class ;
  rdfs:label "lowess transformation"@en ;
  rdfs:comment "A data transformation of normalizing ratio data by using a locally weighted polynomial regression (typically after a log transformation). The regression can be performed on log ratios resulting from the relation of two data sets versus the average log intensity data from the same two data sets or it can be performed on raw or log transformed values from one data set versus values from another. The goal could be to remove intensity-dependent dye-specific effects from the set of pair wise ratios. This method can be applied globally, or limited by one or more specified criteria."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0001382 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-27 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-27 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001198 .

obo:OBI_0400107 a rdfs:Class ;
  rdfs:label "computer" ;
  rdfs:comment "A computer is an instrument which manipulates (stores, retrieves, and processes) data according to a list of instructions."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001973 a rdfs:Class ;
  rdfs:label "ion semiconductor chip" ;
  rdfs:comment "An ion detector that is organized as an electronic circuit whose components, such as transistors and resistors, are etched or deposited on a single slice of semiconductor material to produce a chip. The specific chip detects ion charge induced when an ion passes by or hits a surface."@en ;
  rdfs:subClassOf obo:OBI_0000364 .

obo:OBI_0002553 a rdfs:Class ;
  rdfs:label "uterus specimen" ;
  rdfs:comment "A specimen that is derived from uterus."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000612 a rdfs:Class ;
  rdfs:label "Bruker MATCH tube holder system" ;
  rdfs:comment "The Bruker Multiple Adjustable Tube Clamp Holder MATCH system is a holder for 100 mm long NMR sample tubes with diameters ranging from micro tubes up to 5 mm NMR tubes. The MATCH insert fits into a standard 10 mm Bruker spinner and is suitable for all non-spinning applications.n   The MATCH system provides an easy and cost efficient means of optimizing the signal-to-noise ratio of each sample. By matching the NMR tube diameter to the size of the sample, most of the sample can be placed in the active column of the NMR coil. This leads to an enhanced signal detection compared to diluting the same sample quantity in a larger tube."@en ;
  rdfs:subClassOf obo:OBI_0000484 .

obo:OBI_0000924 a rdfs:Class ;
  rdfs:label "labeled specimen" ;
  rdfs:comment "A specimen  that has been modified in order to be able to detect it in future experiments"@en ;
  rdfs:subClassOf obo:OBI_0001936 , obo:OBI_0100051 .

obo:OBI_0000637 a rdfs:Class ;
  rdfs:label "gas chromatography detector" ;
  rdfs:comment "A gas chromatography detector is a chromatography detector that locates in the dimensions of space and time, the positions of the components of a mixture that has been subjected to a gas chromatographic process and thus permits the senses to appreciate the nature of the separation. There is no LC detector that has an equivalent performance to the flame ionization detector (FID) used in GC. In general, LC detectors have sensitivities of two to three orders of magnitude less than their GC counterparts and linear dynamic ranges one to two orders of magnitude lower. Only highly specific LC detectors have sensitivities that can approach those of GC detectors."@en ;
  rdfs:subClassOf obo:OBI_0000481 .

obo:PR_000085778 a rdfs:Class ;
  rdfs:label "modified histone" ;
  rdfs:comment "A histone that contains one or more amino acid modifications." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003309 a rdfs:Class ;
  rdfs:label "transposase-mediated analysis of chromatin looping assay" ;
  rdfs:comment "A DNA sequencing assay designed to detect interacting genomic regions. Rather than the traditional Hi-C approach of digestion and proximity ligation, the procedure involves transposase-mediated insertion of an oligonucleotide linker between the pair of interacting regions."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0002156 a rdfs:Class ;
  rdfs:label "rapid plasma reagin test" ;
  rdfs:comment "An analyte assay that is meant to detect with the aid of carbon or charcoal particles general antibodies that react with substances that are produced by cellular damage caused by Treponema pallidum indicating a syphilis infection. RPR tests can be done without a microscope."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003712 a rdfs:Class ;
  rdfs:label "assay of organismal behavior" ;
  rdfs:comment "A physical examination to assess behavior quality in a live organism."@en ;
  rdfs:subClassOf obo:OBI_0002441 .

obo:OBI_2100173 a rdfs:Class ;
  rdfs:label "venous blood mycophenolic acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of mycophenolic acid in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0003040 .

obo:OBI_0003458 a rdfs:Class ;
  rdfs:label "epitope protection from tumor challenge experiment based on burden" ;
  rdfs:comment "An epitope protection from tumor challenge experiment in which the readout is a reduction in the presence of malignant cells in the host compared to controls."@en ;
  rdfs:subClassOf obo:OBI_0001183 .

obo:OBI_0000982 a rdfs:Class ;
  rdfs:label "computed tomography scanner" ;
  rdfs:comment "An image acquisition device that generates a three-dimensional image of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation."@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0000805 a rdfs:Class ;
  rdfs:label "antithrombin-III berichrome assay" ;
  rdfs:comment "An antithrombin-III (AT-III) assay in which exogenous bovine thrombin and heparin are added to test plasma to form a thrombin-heparin-AT complex. The residual thrombin not bound then hydrolyzes the p-nitroalanine substrate to produce a yellow color, which is read at 405 nm. The intensity of color produced is inversely proportional to the AT present. A calibration is done with standard human plasma reagent and results for a given specimen are reported as a percentage relative to the standard"@en ;
  rdfs:subClassOf obo:OBI_0000787 .

obo:GO_0045289 a rdfs:Class ;
  rdfs:label "luciferin monooxygenase activity" ;
  rdfs:comment "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." ;
  rdfs:subClassOf obo:GO_0016491 .

obo:MOP_0000543 a rdfs:Class ;
  rdfs:label "physico-chemical process" ;
  rdfs:comment "A process in which at least one of the participants is a molecule." ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBI_0003388 a rdfs:Class ;
  rdfs:label "Agilent-026655 Whole Mouse Genome Microarray 4x44K v2" ;
  rdfs:comment "A DNA microarray manufactured with Agilent 60-mer SurePrint Technology .The SurePrint G3 Mouse Gene Expression 4x44K v2 Microarray provide full coverage of the mouse transcriptome using the latest annotation databases, including long non-coding RNA(lncRNA). Each glass slide is formatted with four high-definition 44K arrays."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_2100347 a rdfs:Class ;
  rdfs:label "bodily fluid cholesterol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of cholesterol in bodily fluid"@en ;
  rdfs:subClassOf obo:OBI_2100031 .

obo:OBI_0001742 a rdfs:Class ;
  rdfs:label "quenching assay measuring the on rate [kon] of a B cell epitope:antibody complex" ;
  rdfs:comment "A fluorescence quenching assay that measures the on rate [kon] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001635 , obo:OBI_0001718 .

obo:OBI_0001161 a rdfs:Class ;
  rdfs:label "age since germination measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since germination, the process consisting of physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0000959 a rdfs:Class ;
  rdfs:label "vibrotome" ;
  rdfs:comment "A preparation device that uses a vibrating razor blade to cut through tissue."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0001445 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002647 a rdfs:Class ;
  rdfs:label "Giemsa stain assay" ;
  rdfs:comment "An assay that uses a Giemsa stain to characterize cells."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002949 a rdfs:Class ;
  rdfs:label "fluorescence imaging-based cell viability assay" ;
  rdfs:comment "A type of cytometry assay in which fluorescent dyes are used to label and detect proteins or structures associated with cell viability."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:UBERON_0001460 a rdfs:Class ;
  rdfs:label "arm" ;
  rdfs:comment "The part of the forelimb extending from the shoulder to the autopod[cjm]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0002457 a rdfs:Class ;
  rdfs:label "precision nuclear run-on sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that maps the genome-wide distribution of transcriptionally-engaged Pol II at base-pair resolution by using biotin-labeled ribonucleotide triphosphate analogs (biotin-NTP) for nuclear run-on reactions, allowing the efficient affinity purification of nascent RNAs for high throughput sequencing from their 3' ends."@en ;
  rdfs:subClassOf obo:OBI_0001271 , obo:OBI_0002692 .

obo:OBI_0000619 a rdfs:Class ;
  rdfs:label "chromatography splitter" ;
  rdfs:comment "An adjustable restriction that is placed in the waste outlet to allow the necessary pressure to develop at the column inlet to force a flow (q ml/min) through the column. If the flow of mobile phase is Q ml/min then the waste flow will be (Q-q) ml/min. by adjusting the waste flow, the proportion of the sample entering the capillary column can be varied over a wide range of values and the necessary minimum permissible volume for the particular column in use can be selected for analysis. Unfortunately, the fraction taken in this way may not be representative of the original sample. This is due to the individual solutes in the mixture having different diffusivities and, thus, they distribute themselves across the sampling tube in an irregular manner. In general, the components with higher diffusivities (e.g., those solutes of lower molecular weight) will diffuse away from the bulk sample more quickly than those having lower diffusivities."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0000831 a rdfs:Class ;
  rdfs:label "DNA residue methylation" ;
  rdfs:comment "a quality of a DNA residue that has a methyl group attached to it"@en ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBI_0600008 a rdfs:Class ;
  rdfs:label "acquisition"@en ;
  rdfs:comment "A planned process with the objective of gaining possession of an entity."@en ;
  rdfs:subClassOf obo:OBI_0001928 .

obo:OBI_0302835 a rdfs:Class ;
  rdfs:label "denatured polymer"@en ;
  rdfs:comment "Is a polymer which has lost secondary or tertiary structure"@en ;
  rdfs:subClassOf obo:CHEBI_33839 .

obo:OBI_0000971 a rdfs:Class ;
  rdfs:label "fresh specimen" ;
  rdfs:comment "a specimen that is output of a specimen creation process used for an investigation without storage."@en ;
  rdfs:subClassOf obo:OBI_0001472 .

obo:PATO_0001757 a rdfs:Class ;
  rdfs:label "electrical conductivity" ;
  rdfs:comment "A conductivity quality inhering in a bearer by virtue of the bearer's ability to convey electricity." ;
  rdfs:subClassOf obo:PATO_0001585 .

obo:OBI_0000369 a rdfs:Class ;
  rdfs:label "magnify function"@en ;
  rdfs:comment "A magnify function is a function to increase the size of a transmitted object image through the precise arrangement of energy diffraction elements along an imaging path."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0003575 a rdfs:Class ;
  rdfs:label "scratching"@en ;
  rdfs:comment "A process in which the target material entity is scraped by another material entity."@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBI_0001861 a rdfs:Class ;
  rdfs:label "methylation-sensitive restriction enzyme sequencing assay" ;
  rdfs:comment "An assay that identifies unmethylated CpGs using methylation sensitive restriction enzymes to fragment DNA."@en ;
  rdfs:subClassOf obo:OBI_0000626 , obo:OBI_0001266 .

obo:OBI_0000664 a rdfs:Class ;
  rdfs:label "BrdU incorporation assay" ;
  rdfs:comment "A cell proliferation assay in which cells are cultured in the presence of BrdU which is incorporated into newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication, which can be quantified by BrdU specific antibodies."@en ;
  rdfs:subClassOf obo:OBI_0000891 .

obo:OBI_0000015 a rdfs:Class ;
  rdfs:label "biological feature identification objective"@en ;
  rdfs:comment "Biological_feature_identification_objective is an objective role carried out by the proposition defining the aim of a study designed to examine or characterize a particular biological feature."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:UBERON_0000947 a rdfs:Class ;
  rdfs:label "aorta" ;
  rdfs:comment "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." ;
  rdfs:subClassOf obo:UBERON_0001981 .

obo:OBI_2100079 a rdfs:Class ;
  rdfs:label "corrected venous blood leukocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of leukocytes in venous blood as part of a corrected order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:OBI_0001769 a rdfs:Class ;
  rdfs:label "specimen collector role"@en ;
  rdfs:comment """An Investigation agent role borne by a person or organization which 
is realized in a specimen collection process."""@en ;
  rdfs:subClassOf obo:OBI_0000202 .

obo:MRO_0001538 a rdfs:Class ;
  rdfs:label "HLA protein complex with A29 serotype" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:OBI_0003702 a rdfs:Class ;
  rdfs:label "phase III clinical trial"@en ;
  rdfs:comment "A clinical trial that produces information about a drug's safety and effectiveness in different populations, with different dosages, and in combination with other drugs."@en ;
  rdfs:subClassOf obo:OBI_0003699 .

obo:OBI_0002554 a rdfs:Class ;
  rdfs:label "vagina specimen" ;
  rdfs:comment "A specimen that is derived from vagina."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001273 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-5 production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interleukin-5 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001230 .

obo:OBI_0200164 a rdfs:Class ;
  rdfs:label "proportion of expected false positives correction method"@en ;
  rdfs:comment "A proportion of expected false positives correction method is a multiple testing procedure that controls the ratio of the expected value of the numbers of false positives to the expected value of the numbers of rejected hypotheses."@en ;
  rdfs:subClassOf obo:OBI_0200089 .

obo:OBI_0000570 a rdfs:Class ;
  rdfs:label "spin column" ;
  rdfs:comment "A spin column is a chromatography column which is suitable for putting it into a centrifuge. A spin column enforces separation through increased G-forces while spinning the column in a centrifuge. It is often used in DNA gel extraction kits."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0001079 a rdfs:Class ;
  rdfs:label "confocal microscope" ;
  rdfs:comment "A microscope that is used to increase micrograph contrast and/or reconstruct three-dimensional images by using a spatial pinhole to eliminate out-of-focus light in specimens that are thicker than the focal plane."@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:OBI_0000870 a rdfs:Class ;
  rdfs:label "single-nucleotide-resolution nucleic acid structure mapping assay" ;
  rdfs:comment "An assay that provides information about the secondary structure of nucleic acids using chemical or enzymatic probing to establish the extent of base-pairing or solvent accessiblity."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100039 a rdfs:Class ;
  rdfs:label "osmolality assay" ;
  rdfs:comment "An assay that measures osmolality"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002032 a rdfs:Class ;
  rdfs:label "parallel analysis of RNA structure assay" ;
  rdfs:comment "A single-nucleotide-resolution nucleic acid structure mapping assay that performs simultaneous in vitro profiling of the secondary structure of thousands of RNA species at single nucleotide resolution using enzymatic probing based on deep sequencing fragments of RNAs that were treated with structure-specific enzymes"@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:OBI_2100285 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0002188 a rdfs:Class ;
  rdfs:label "multi-unit recording" ;
  rdfs:comment "An extracellular electrophysiology assay where a collection of microelectrodes (often in an 'array' configuration) is placed into neural tissue to measure the distribution of voltage and current changes for a population of cells over time."@en ;
  rdfs:subClassOf obo:OBI_0000454 .

obo:OBI_0003233 a rdfs:Class ;
  rdfs:label "endotracheal aspirate assay" ;
  rdfs:comment "An assay that has an endotracheal aspirate specimen as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0302896 a rdfs:Class ;
  rdfs:label "cervical dislocation"@en ;
  rdfs:comment "cervical dislocation is a process by which a Vertebrate organism has its life terminated by rupturing spinal cord between cervical vertebrae induced by excessive mechanical torsion"@en ;
  rdfs:subClassOf obo:OBI_0000919 .

obo:PATO_0000001 a rdfs:Class ;
  rdfs:label "quality" ;
  rdfs:comment "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" ;
  rdfs:subClassOf obo:COB_0000502 .

obo:OBI_0600052 a rdfs:Class ;
  rdfs:label "dialysis"@en ;
  rdfs:comment "a protocol application that uses diffusion through a semi-permeable membrane to separate an input material into two fractions of different composition"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:GO_0032906 a rdfs:Class ;
  rdfs:label "transforming growth factor beta2 production" ;
  rdfs:comment "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003779 a rdfs:Class ;
  rdfs:label "chemiluminescent assay" ;
  rdfs:comment "An analyte assay that detects a substance by measuring the release of light triggered by a chemical reaction."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003276 a rdfs:Class ;
  rdfs:label "eukaryota in nasopharyngeal or oropharyngeal swab datum" ;
  rdfs:comment "A nasopharyngeal or oropharyngeal swab microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003257 .

obo:OBI_0001895 a rdfs:Class ;
  rdfs:label "specimen collector"@en ;
  rdfs:comment "A person who collects the specimen"@en ;
  rdfs:subClassOf obo:NCBITaxon_9606 .

obo:OBI_0001191 a rdfs:Class ;
  rdfs:label "half maximal inhibitory concentration (IC50)" ;
  rdfs:comment "Half maximal inhibitory concentration (IC50) is a scalar measurement datum that measures the effectiveness of a compound to competitively inhibit a given process, and corresponds to the concentration of the compound at which it reaches half of its maximum inhibitory effect."@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0003302 a rdfs:Class ;
  rdfs:label "micro-C assay" ;
  rdfs:comment "A Hi-C assay which uses micrococcal nuclease digestion in place of the restriction enzyme digestion step."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:OBI_0000385 a rdfs:Class ;
  rdfs:label "ionization function"@en ;
  rdfs:comment "An ionization function is a function to physically convert an atom or molecule into an ion by adding or removing charged particles such as electrons or other ions."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0003128 a rdfs:Class ;
  rdfs:label "T cell epitope assay" ;
  rdfs:comment "An immune epitope assay that characterizes the structrue of an epitope-T cell receptor complex, or measures the binding of a T cell receptor to epitope, or the immune response process resulting from such a binding event or the recognition of the epitope."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110128 .

obo:OBI_0001371 a rdfs:Class ;
  rdfs:label "epitope specific granzyme B production by T cells" ;
  rdfs:comment "A process of granzyme B production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071613 .

obo:CHEBI_25555 a rdfs:Class ;
  rdfs:label "nitrogen atom" ;
  rdfs:subClassOf obo:COB_0000011 .

obo:OBI_0500004 a rdfs:Class ;
  rdfs:label "n-to-1 design" ;
  rdfs:comment "N-of-1 design is a cross-over design in which the same patient is repeatedly randomised to receive either the experimental treatment or its control (Senn, 1993)."@en ;
  rdfs:subClassOf obo:OBI_0500003 .

obo:OBI_0000477 a rdfs:Class ;
  rdfs:label "Varian GEMINI spectrometer" ;
  rdfs:comment "An older Varian Broadband NMR spectrometer."@en ;
  rdfs:subClassOf obo:OBI_0000611 .

obo:OBI_1110178 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-17 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-17 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001295 .

obo:OBI_0002140 a rdfs:Class ;
  rdfs:label "temperature measurement assay" ;
  rdfs:comment "An assay to determine the temperature of an evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_1110022 a rdfs:Class ;
  rdfs:label "adaptive immune receptor"@en ;
  rdfs:comment "is a receptor produced by cells of the adaptive immune system with the purpose of binding epitopes."@en ;
  rdfs:subClassOf obo:GO_0032991 .

obo:IAO_0000010 a rdfs:Class ;
  rdfs:label "software"@en ;
  rdfs:comment """Software is a plan specification composed of a series of instructions that can be 
interpreted by or directly executed by a processing unit."""@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0001921 a rdfs:Class ;
  rdfs:label "RNA-binding protein immunoprecipitation tiling array profiling assay" ;
  rdfs:comment "An RNA-binding protein immunoprecipitation array profiling assay that combines immunoprecipitation of an RNA-binding protein and RNA tiling array to identify mRNAs associated with selected RNA binding proteins (RBPs)."@en ;
  rdfs:subClassOf obo:OBI_0001918 .

obo:OBI_0003532 a rdfs:Class ;
  rdfs:label "lower limb coordination assessment" ;
  rdfs:comment "A limb coordination assessment designed to assess an individual's ability to coordinate lower limb movement."@en ;
  rdfs:subClassOf obo:OBI_0003530 .

obo:OBI_0200055 a rdfs:Class ;
  rdfs:label "dye swap merge"@en ;
  rdfs:comment "A dye swap merge is a replicate analysis which takes as input data from paired two-channel microarray assays where the sample labeled with one dye in the first assay is labeled with the other dye in the second assay and vice versa. The output for each reporter is obtained by combining its (raw or possibly pre-processed) M values in the two assays, where the M value in an assay is defined as the difference of the log intensities in the two channels. This can be used as a normalization step, when appropriate assumptions are met."@en ;
  rdfs:subClassOf obo:OBI_0200057 .

obo:OBI_0003662 a rdfs:Class ;
  rdfs:label "single-nucleus methylcytosine and transcriptome sequencing assay" ;
  rdfs:comment "A DNA methylation profiling by high throughput sequencing assay that measures the cytosine DNA methylation and gene expression signature of single nuclei."@en ;
  rdfs:subClassOf obo:OBI_0001177 , obo:OBI_0001266 .

obo:OBI_0001714 a rdfs:Class ;
  rdfs:label "B cell epitope specific immunoglobulin-mediated neutralization" ;
  rdfs:comment "immunoglobulin-mediated neutralization resulting from antibody binding to epitope"@en ;
  rdfs:subClassOf obo:GO_0097282 .

obo:OBI_0400068 a rdfs:Class ;
  rdfs:label "LSR2" ;
  rdfs:comment "A LSR2 is a sorter manufactured by Becton Dickinson. It features digital electronics, a solid state 488 nm blue laser and optionally can also have any combination of solid state UV (355 nm) and violet (405 nm) lasers and the a HeNe (633 nm) ion laser. The LSR2 has the filters and PMTs to work with 13 fluorescent parameters. The LSR II is one of the most common sorters in use."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0003623 a rdfs:Class ;
  rdfs:label "antibody purification of HLA-C protein complex" ;
  rdfs:comment "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-C protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003617 .

obo:OBI_0001932 a rdfs:Class ;
  rdfs:label "comparing prediction to measurement" ;
  rdfs:comment "A planned process in which predicted values for some thing are compared to measured values for that thing."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002672 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific perforin release by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects epitope specific perforin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001497 .

obo:OBI_0001039 a rdfs:Class ;
  rdfs:label "inline probing RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at nucleotide resolution scale using intromolecular reactivity"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0003222 a rdfs:Class ;
  rdfs:label "insulin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of insulin"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003165 a rdfs:Class ;
  rdfs:label "myelocyte count assay" ;
  rdfs:comment "A myelocyte assay that measures the number of myelocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003016 .

obo:OBI_0000224 a rdfs:Class ;
  rdfs:label "sub-investigator role"@en ;
  rdfs:comment "a worker role authorized to make study-related decisions and carry out tasks related to the study; this role occurs during the study timeline"@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:OBI_0001093 a rdfs:Class ;
  rdfs:label "microtome knife sharpener" ;
  rdfs:comment "A device that is used to sharpen knives used in microtomy."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000742 a rdfs:Class ;
  rdfs:label "nucleic acid restriction enzyme digest" ;
  rdfs:comment "A nucleic acid digest is a material that is the output of a process in which nucleic acids are combined with a restriction enzyme resulting in digested fragments with defined ends based on the enzymes cleavage site"@en ;
  rdfs:subClassOf obo:CHEBI_33696 .

obo:OBI_0001124 a rdfs:Class ;
  rdfs:label "micropipette puller" ;
  rdfs:comment "A device that is used to fabricate glass micropipettes."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001627 a rdfs:Class ;
  rdfs:label "country name"@en ;
  rdfs:comment "A textual entity that denotes a geographic location that is a site or part of a site that is identified as a country in the political geography."@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:OBI_0002199 a rdfs:Class ;
  rdfs:label "reason for lack of data item" ;
  rdfs:comment "An information content entity that provides an explanation why a data item is not provided."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:CHEBI_29103 a rdfs:Class ;
  rdfs:label "potassium(1+)" ;
  rdfs:comment "A monoatomic monocation obtained from potassium." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0302885 a rdfs:Class ;
  rdfs:label "filtration"@en ;
  rdfs:comment "filtration is a process which separates components suspended in a fluid based on granularity properties relying on a filter device"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0000093 a rdfs:Class ;
  rdfs:label "patient role"@en ;
  rdfs:comment "a role which inheres in a person and is realized by the process of being under the care of a physician or health care provider"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000917 a rdfs:Class ;
  rdfs:label "nasal swab specimen" ;
  rdfs:comment "A specimen obtained using a cotton swab on a stick, passed up the nostril to obtain a sample of exudate and epithelial debris for microbiological or cellular examination."@en ;
  rdfs:subClassOf obo:OBI_0002599 , obo:OBI_2000006 .

obo:OBI_0003125 a rdfs:Class ;
  rdfs:label "mosaicism with repeat frameshift genetic sparse labeling" ;
  rdfs:comment "A 3D neural cell structure determination assay where sparse and stochastic methods are used to label genetically-defined neurons."@en ;
  rdfs:subClassOf obo:OBI_0003123 .

obo:OBI_0003914 a rdfs:Class ;
  rdfs:label "single cell massively parallel reporter assay" ;
  rdfs:comment "A massively parallel reporter assay in which libraries of reporter constructs are transfected into samples and then measured via single cell transcriptomic methods to enable discovery of cell-specific transcriptional regulatory activity"@en ;
  rdfs:subClassOf obo:OBI_0002675 .

obo:OBI_0003853 a rdfs:Class ;
  rdfs:label "hypersensitivity assay" ;
  rdfs:comment "An immune response assay to assess the hypersensitivity response in an organism or cell culture."@en ;
  rdfs:subClassOf obo:OBI_0000743 .

obo:OBI_1110038 a rdfs:Class ;
  rdfs:label "RMA cell line"@en ;
  rdfs:comment "A cell line derived from a mouse lymphoma, specifically a Rauscher virus-induced tumor.This cell ine is antigen processing-defective and expresses a very low level of MHC molecules on its surface."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0001146 a rdfs:Class ;
  rdfs:label "binding assay" ;
  rdfs:comment "An assay with the objective to characterize the disposition of two or more material entities to form a complex."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003555 a rdfs:Class ;
  rdfs:label "vaginal administration" ;
  rdfs:comment "An administration of a substance into the vagina of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0001866 a rdfs:Class ;
  rdfs:label "secondary cultured cell" ;
  rdfs:comment "A cultured cell that has been passaged or derives from a cell that has been passaged in culture."@en ;
  rdfs:subClassOf obo:CL_0000010 .

obo:OBI_0001180 a rdfs:Class ;
  rdfs:label "half maximal effective concentration (EC50)" ;
  rdfs:comment "half maximal effective concentration (EC50) is a scalar measurement datum corresponding to the concentration of a compound which induces a response halfway between the baseline and maximum after some specified exposure time."@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0003572 a rdfs:Class ;
  rdfs:label "intraplacental administration" ;
  rdfs:comment "An administration of a substance into the placenta of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0002606 a rdfs:Class ;
  rdfs:label "nasopharyngeal swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of a nasopharynx."@en ;
  rdfs:subClassOf obo:OBI_0002599 , obo:OBI_2000007 .

obo:OBI_0002170 a rdfs:Class ;
  rdfs:label "genomic SELEX" ;
  rdfs:comment "A systematic evolution of ligands by exponential enrichment assay that starts with a library derived from genomic DNA instead of synthetically derived random DNA molecules."@en ;
  rdfs:subClassOf obo:OBI_0002161 .

obo:OBI_0400070 a rdfs:Class ;
  rdfs:label "Luminex 200" ;
  rdfs:comment "A Luminex_200 is a flow_cytometer_analyser manufactured by Luminex. The optical specifications are: Reporter laser: 532 nm, nominal output 10 - 15 mW, maximum 500 mW, frequency-doubled diode; mode of operation, continuous wave (CW). Classification laser: 635 nm, 9.1 __ 6%, maximum output 25 mW, diode; mode of operation, continuous wave (CW) Reporter detector: Photomultiplier tube, detection bandwidth of 565 - 585 nm Classification detector and doublet discriminator: Avalanche photo diodes with temperature compensation"@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0003013 a rdfs:Class ;
  rdfs:label "transferrin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of transferrin"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:OBI_2100157 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood human aspartate aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100019 .

obo:OBI_0003701 a rdfs:Class ;
  rdfs:label "phase II clinical trial"@en ;
  rdfs:comment "A clinical trial that produces information about a drug's effectiveness and short-term adverse events associated with the drug."@en ;
  rdfs:subClassOf obo:OBI_0003699 .

obo:OBI_0003586 a rdfs:Class ;
  rdfs:label "Annexin V staining"@en ;
  rdfs:comment "Staining using Annexin V to detect apoptotic cells."@en ;
  rdfs:subClassOf obo:OBI_0302887 .

obo:OBI_0001172 a rdfs:Class ;
  rdfs:label "dose response curve" ;
  rdfs:comment "A data item of paired values, one indicating the dose of a material, the other quantitating a measured effect at that dose. The dosing intervals are chosen so that effect values be interpolated by a plotting a curve."@en ;
  rdfs:subClassOf obo:IAO_0000573 .

obo:OBI_0000626 a rdfs:Class ;
  rdfs:label "DNA sequencing assay" ;
  rdfs:comment "A sequencing assay which determines information on the sequence of a DNA molecule."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:PR_000025478 a rdfs:Class ;
  rdfs:label "ribonuclease CL3 (chicken)" ;
  rdfs:comment "A protein with ribonuclease activity that is purified from chicken liver." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003850 a rdfs:Class ;
  rdfs:label "cytochrome P450 assay" ;
  rdfs:comment "A protein assay that measures the abundance of cytochrome P450 in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100023 .

obo:OBI_0002513 a rdfs:Class ;
  rdfs:label "placenta specimen" ;
  rdfs:comment "A specimen that is derived from placenta."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0003187 a rdfs:Class ;
  rdfs:label "immature neutrophil percentage assay" ;
  rdfs:comment "An neutrophil assay that measures the percentage of immature neutrophils in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003022 .

obo:OBI_0000720 a rdfs:Class ;
  rdfs:label "immunologic adjuvant role" ;
  rdfs:comment "The role a material entity plays when it is co-administered with an immunogen in order to enhance the immune response to the immunogen."@en ;
  rdfs:subClassOf obo:OBI_1110092 .

obo:OBI_0001902 a rdfs:Class ;
  rdfs:label "sample preparation for sequencing assay"@en ;
  rdfs:comment "A sample preparation for assay that preparation of nucleic acids for a sequencing assay"@en ;
  rdfs:subClassOf obo:OBI_0000073 .

obo:SO_0000001 a rdfs:Class ;
  rdfs:label "region" ;
  rdfs:comment "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0002424 a rdfs:Class ;
  rdfs:label "chemotherapy treatment exclusion criterion" ;
  rdfs:comment "An exclusion criterion that defines whether chemotherapy was received or is being received for a previous  or current cancer, which when met, makes an individual unsuitable for a given task or participation in a given process"@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0003789 a rdfs:Class ;
  rdfs:label "immune receptor repertoire profiling assay" ;
  rdfs:comment "An assay that determines the sequence of a DNA or RNA molecules that encode the repertoire of B cell receptors or T cell receptors within an input sample."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100046 a rdfs:Class ;
  rdfs:label "3,3',5'-triiodothyronine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of 3,3',5'-triiodothyronine"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002632 a rdfs:Class ;
  rdfs:label "PacBio Sequel" ;
  rdfs:comment "A DNA sequencer built upon single molecule real-time sequencing technology, optimized for generation with long reads and high consensus accuracy, and manufactured by the Pacific Biosciences corporation"@en ;
  rdfs:subClassOf obo:OBI_0003923 .

obo:CL_0011012 a rdfs:Class ;
  rdfs:label "neural crest cell" ;
  rdfs:comment "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0000618 a rdfs:Class ;
  rdfs:label "size exclusion column" ;
  rdfs:comment "A size exclusion column is a chromatography column as used in size exclusion chromatography and which enables the separation of mixtures according to differrences in molecular size."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0001348 a rdfs:Class ;
  rdfs:label "in vivo skin test assay measuring T cell epitope specific type IV hypersensitivity" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that detects epitope specific type IV hypersensitivity."@en ;
  rdfs:subClassOf obo:OBI_0001178 , obo:OBI_0001484 .

obo:CHEBI_61073 a rdfs:Class ;
  rdfs:label "oxygen radical" ;
  rdfs:comment "An inorganic radical in which a free electron resides on one or more oxygen atoms of an oxygen species." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:GO_0032609 a rdfs:Class ;
  rdfs:label "type II interferon production" ;
  rdfs:comment "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0003887 a rdfs:Class ;
  rdfs:label "NAI-N3 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using 2-(azidomethyl)nicotinic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0003107 a rdfs:Class ;
  rdfs:label "slide-seq assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that involves transfer of RNA from tissue sections onto a surface covered in DNA-barcoded beads with known positions, allowing the locations of the RNA to be inferred by sequencing."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0002596 a rdfs:Class ;
  rdfs:label "self interaction identification design" ;
  rdfs:comment "A molecular interaction identification design that investigates intra-molecular interactions between two or more regions of a single molecule."@en ;
  rdfs:subClassOf obo:OBI_0002590 .

obo:OBI_0400111 a rdfs:Class ;
  rdfs:label "hybridization station" ;
  rdfs:comment "A device which is used to maintain the temperature of one or more hybridization_chamber(s) at a defined, constant temperature."@en ;
  rdfs:subClassOf obo:OBI_0001034 .

obo:OBI_2100124 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of cells in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:OBI_2100358 a rdfs:Class ;
  rdfs:label "venous blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0001187 a rdfs:Class ;
  rdfs:label "infectious agent detection assay" ;
  rdfs:comment "An assay that measures the presence or amount of an infectious agent in an evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0032621 a rdfs:Class ;
  rdfs:label "interleukin-18 production" ;
  rdfs:comment "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0001996 a rdfs:Class ;
  rdfs:label "chromatography assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "An analytical chromatography assay that measures the dissociation constant [KD] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001630 , obo:OBI_0001708 .

obo:NCBITaxon_7147 a rdfs:Class ;
  rdfs:label "Diptera" ;
  rdfs:subClassOf obo:NCBITaxon_197562 .

obo:OBI_2100086 a rdfs:Class ;
  rdfs:label "liver evaluation venous blood protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in venous blood as part of a liver evaluation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0003379 a rdfs:Class ;
  rdfs:label "switching mechanism at the 5' end of RNA template sequencing 2 assay" ;
  rdfs:comment "A single cell transcription profiling by RNA sequencing assay that is a variation on the switching mechanism at the 5' end of RNA template sequencing assay (SMARTseq) that allows the generation of full-length cDNA and sequencing libraries by using standard reagents."@en ;
  rdfs:subClassOf obo:OBI_0002631 .

obo:GO_0016064 a rdfs:Class ;
  rdfs:label "immunoglobulin mediated immune response" ;
  rdfs:comment "An immune response mediated by immunoglobulins, whether cell-bound or in solution." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBIB_0000661 a rdfs:Class ;
  rdfs:label "fixed tissue slide specimen"@en ;
  rdfs:comment "A fixed tissue specimen that is placed in a slide."@en ;
  rdfs:subClassOf obo:OBIB_0000659 .

obo:PATO_0002201 a rdfs:Class ;
  rdfs:label "handedness" ;
  rdfs:comment "A behavioral quality inhering ina bearer by virtue of the bearer's unequal distribution of fine motor skill between its left and right hands or feet." ;
  rdfs:subClassOf obo:PATO_0000186 .

obo:OBI_0002125 a rdfs:Class ;
  rdfs:label "H&E-stained fixed tissue slide specimen" ;
  rdfs:comment "A fixed tissue slide specimen that is the output of H&E slide staining."@en ;
  rdfs:subClassOf obo:OBIB_0000661 .

obo:OBI_1110033 a rdfs:Class ;
  rdfs:label "JAWS II cell line"@en ;
  rdfs:comment "A cell line derived from mouse dendritic cells."@en ;
  rdfs:subClassOf obo:CLO_0009828 .

obo:OBI_0003027 a rdfs:Class ;
  rdfs:label "macrophage assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of macrophages"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000171 a rdfs:Class ;
  rdfs:label "autotransplantation"@en ;
  rdfs:comment "is the transplantation of tissue from one part of \\nthe body to another in the same individual. )"@en ;
  rdfs:subClassOf obo:OBI_0000105 .

obo:OBI_0002006 a rdfs:Class ;
  rdfs:label "1M-Duo Infinium HD BeadChip" ;
  rdfs:comment "A BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array integrates ~ 1 million markers per sample for genotyping, and copy number variation (CNV) and Cytogenetic analysis."@en ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:OBI_0000819 a rdfs:Class ;
  rdfs:label "anticoagulant tube storage of blood specimen" ;
  rdfs:comment "Storage of a blood specimen in a tube with anticoagulant"@en ;
  rdfs:subClassOf obo:OBI_0302893 .

obo:UBERON_0003102 a rdfs:Class ;
  rdfs:label "surface structure" ;
  rdfs:comment "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001043 a rdfs:Class ;
  rdfs:label "cell transfer function" ;
  rdfs:comment "is a transfer function that displaces cells from one place to another"@en ;
  rdfs:subClassOf obo:OBI_0000383 .

obo:OBI_0400011 a rdfs:Class ;
  rdfs:label "avalanche photodiode" ;
  rdfs:comment "An avalanche photodiode is typically used to collect photons emitted by forward scatter because it is far less sensitive, and less likely o be burned out, than a PMT. A photodiode with high quantum efficiency and a mechanism for producing gains as high as a few thousand."@en ;
  rdfs:subClassOf obo:OBI_0400083 .

obo:OBI_1110049 a rdfs:Class ;
  rdfs:label "allergy"@en ;
  rdfs:comment "is a disease in which an abnormally strong inflammatory immune response is triggered against non-self entities, and the immune response has no protective effect"@en ;
  rdfs:subClassOf obo:OGMS_0000031 .

obo:IAO_0000032 a rdfs:Class ;
  rdfs:label "scalar measurement datum"@en ;
  rdfs:comment "A scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_2100310 a rdfs:Class ;
  rdfs:label "high sensitivity cardiac/neonatal venous blood c-reactive protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of c-reactive protein in venous blood as part of a high sensitivity cardiac/neonatal order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100047 .

obo:NCBITaxon_4890 a rdfs:Class ;
  rdfs:label "Ascomycota" ;
  rdfs:subClassOf obo:NCBITaxon_33154 .

obo:OBI_0000310 a rdfs:Class ;
  rdfs:label "adverse event trigger"@en ;
  rdfs:comment "revisit?"@en ;
  rdfs:subClassOf obo:IAO_0000001 .

obo:OBI_0003892 a rdfs:Class ;
  rdfs:label "B5 RNA structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at the nucleotide resolution scale using benzotriazole-5-carboxylic acid imidazolide as reagent and chemical probe"@en ;
  rdfs:subClassOf obo:OBI_0001017 .

obo:OBI_0001956 a rdfs:Class ;
  rdfs:label "assay using chromatin immunoprecipitation" ;
  rdfs:comment "An assay that produces data about protein-DNA interaction or DNA epigenetic modification using immunoprecipitation"@en ;
  rdfs:subClassOf obo:OBI_0001700 .

obo:OBI_0001731 a rdfs:Class ;
  rdfs:label "surface plasmon resonance assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A surface plasmon resonance binding assay that measures the dissociation constant [KD] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000923 , obo:OBI_0001708 .

obo:OBI_1110001 a rdfs:Class ;
  rdfs:label "epitope"@en ;
  rdfs:comment "A material entity with the disposition to be bound by an adaptive immune receptor."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_2100005 a rdfs:Class ;
  rdfs:label "basophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of basophils"@en ;
  rdfs:subClassOf obo:OBI_0003021 .

obo:OBI_0000879 a rdfs:Class ;
  rdfs:label "random primed DNA labeling" ;
  rdfs:comment "a labeling in which random primers are used to uniformly label input DNA"@en ;
  rdfs:subClassOf obo:OBI_0600038 .

obo:OBI_0000717 a rdfs:Class ;
  rdfs:label "HeliScope Single Molecule Sequencer" ;
  rdfs:comment "is a DNA sequencer manufacturer by Helicos Corporation to carry out Single Molecule sequencing using reversible termination chemistry"@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0000735 a rdfs:Class ;
  rdfs:label "NTP-2000" ;
  rdfs:comment "a material consisting of 14.5% protein, 8.5% fat and 9.5% fiber produced to feed rodents"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0003057 a rdfs:Class ;
  rdfs:label "antibiotic administration process" ;
  rdfs:comment "Administering substance in vivo where an antibiotic substance is administered to a living organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:ENVO_01001110 a rdfs:Class ;
  rdfs:label "ecosystem"@en ;
  rdfs:comment "An environmental system which includes both living and non-living components." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0003554 a rdfs:Class ;
  rdfs:label "intracolonic administration" ;
  rdfs:comment "An administration of a substance into the colon of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0003533 a rdfs:Class ;
  rdfs:label "nervous system functionality assessment" ;
  rdfs:comment "A functional assesment of an individual's nerve performance. Specifically the nerves connecting the sensory and motor structures with the central nervous system."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0001609 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific interleukin-8 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects interleukin-8 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001218 .

obo:UBERON_0002032 a rdfs:Class ;
  rdfs:label "areola" ;
  rdfs:comment "Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle and modified sebaceous glands and which surrounds the nipple." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003827 a rdfs:Class ;
  rdfs:label "speed measurement assay" ;
  rdfs:comment "An assay to determine the speed of an evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002393 a rdfs:Class ;
  rdfs:label "pregnancy history" ;
  rdfs:comment "A clinical history in which a female has had a pregnancy."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0000529 a rdfs:Class ;
  rdfs:label "JEOL NMR probe" ;
  rdfs:comment "An NMR probe that is manufactured by JEOL."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_0001111 a rdfs:Class ;
  rdfs:label "paraffin oven" ;
  rdfs:comment "A device that is used for the warming of paraffin embedding medium."@en ;
  rdfs:subClassOf obo:OBI_0000967 , obo:OBI_0001034 .

obo:OBI_0002718 a rdfs:Class ;
  rdfs:label "insecticide resistance time response by WHO paper kit assay" ;
  rdfs:comment "An insecticide resistance time response assay using WHO paper kit, with the presence of a synergist."@en ;
  rdfs:subClassOf obo:OBI_0002709 .

obo:OBI_0000436 a rdfs:Class ;
  rdfs:label "needle" ;
  rdfs:comment "A needle is a sharp, hollow device used to penetrate tissue or soft material. When attached to a syringe. it allows delivery of a specific volume of liquid or gaseous mixture."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0200137 a rdfs:Class ;
  rdfs:label "network subgraph quality calculation"@en ;
  rdfs:comment "A network analysis in which an input data set describing node objects and edge relationships between node objects is used to determine the output quality of a subgraph partition of the network."@en ;
  rdfs:subClassOf obo:OBI_0200080 .

obo:OBI_0002169 a rdfs:Class ;
  rdfs:label "ChIP-qPCR assay" ;
  rdfs:comment "A ChIP assay that uses quantitative PCR to determine levels of specific DNA in immunoprecipitated samples."@en ;
  rdfs:subClassOf obo:OBI_0001954 , obo:OBI_0002692 .

obo:OBI_0002430 a rdfs:Class ;
  rdfs:label "history of metastatic cancer exclusion criterion" ;
  rdfs:comment "An exclusion criterion defined as whether an individual has ever been diagnosed with metastatic cancer (cancer that spread beyond the initial site such as to other organs like brain bone or liver), which if met, makes the individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:OBI_0002177 a rdfs:Class ;
  rdfs:label "patch clamp assay" ;
  rdfs:comment "An intracellular electrophysiology assay where a glass micropipette is sealed to the surface of the cell membrane as a recording electrode to study ion channel activity. The key distinction of this technique is the electrical resistance of the seal between the cell membrane and the pipette is of the order 10-100 gigaohms, permitting high-resolution current measurements over the cell membrane in several different standard configurations."@en ;
  rdfs:subClassOf obo:OBI_0000447 .

obo:OBI_0003038 a rdfs:Class ;
  rdfs:label "parasite detection assay" ;
  rdfs:comment "An assay that detects parasite in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0003024 a rdfs:Class ;
  rdfs:label "lymphocyte assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of lymphocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:GO_0001964 a rdfs:Class ;
  rdfs:label "startle response" ;
  rdfs:comment "An action or movement due to the application of a sudden unexpected stimulus." ;
  rdfs:subClassOf obo:GO_0050896 , obo:GO_0050905 .

obo:OBI_0400101 a rdfs:Class ;
  rdfs:label "voltage amplifier" ;
  rdfs:comment "A voltage amplifier is a device that amplifies the voltage signal."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003594 a rdfs:Class ;
  rdfs:label "human leukocyte antigen mismatch count"@en ;
  rdfs:comment "A genetic characteristics information that is about the number of dissimilarities in the human leukocyte antigen gene complexes of two humans."@en ;
  rdfs:subClassOf obo:OBI_0001404 .

obo:UBERON_0002386 a rdfs:Class ;
  rdfs:label "forelimb zeugopod" ;
  rdfs:comment "The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0200052 a rdfs:Class ;
  rdfs:label "probabilistic algorithm"@en ;
  rdfs:comment "A probabilistic algorithm is one which involves an element of probability or randomness in the transformation of the data."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0003612 a rdfs:Class ;
  rdfs:label "electron microscopy assay determining the 3D structure of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a T cell epitope:MHC:TCR complex."@en ;
  rdfs:subClassOf obo:OBI_0001999 , obo:OBI_0003118 .

obo:OBI_0002215 a rdfs:Class ;
  rdfs:label "histologic grade for ovarian tumor" ;
  rdfs:comment "A categorical value specification that is a histologic grade assigned to a ovarian tumor."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0000422 a rdfs:Class ;
  rdfs:label "syringe" ;
  rdfs:comment "A processed material which is used to introduce or draw fluids from a material entity. A syringe is made of a piston and body. the movement of the piston in the body determines the amount/volume of fluid to inject or draw"@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000182 a rdfs:Class ;
  rdfs:label "NMR 3D molecular structure determination assay" ;
  rdfs:comment "A 3D molecular structure determination assay that uses magnetic properties of atomic nuclei to determine the 3D structure and dynamics of molecules in the input sample."@en ;
  rdfs:subClassOf obo:OBI_0003117 .

obo:OBI_0003048 a rdfs:Class ;
  rdfs:label "BG-lure scent dispenser" ;
  rdfs:comment "A device manufactured by BioGents that is designed for operation with the BG-Sentinel trap and releases an attractant that mimics the scent of human skin."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:MRO_0000997 a rdfs:Class ;
  rdfs:label "H2-Ld protein complex" ;
  rdfs:subClassOf obo:MRO_0001460 .

obo:OBI_0001547 a rdfs:Class ;
  rdfs:label "material analysis service" ;
  rdfs:comment "A service in which a service consumer provides some input material and a service provider performs some analysis of this material to generate data that is returned to the service consumer."@en ;
  rdfs:subClassOf obo:OBI_0001528 .

obo:OBI_0000202 a rdfs:Class ;
  rdfs:label "investigation agent role" ;
  rdfs:comment "A role borne by an entity and that is realized in a process that is part of an investigation in which an objective is achieved. These processes include, among others: planning, overseeing, funding, reviewing."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002387 a rdfs:Class ;
  rdfs:label "diagnosis of hepatitis C" ;
  rdfs:comment "A diagnosis of infectious disease caused by the hepatitis C virus."@en ;
  rdfs:subClassOf obo:OBI_0002385 .

obo:OBI_0000154 a rdfs:Class ;
  rdfs:label "role of Institutional Review Board"@en ;
  rdfs:comment "the role of a organization that is realized by members reviewing study designs for their agreement with regulations"@en ;
  rdfs:subClassOf obo:OBI_0000014 .

obo:OBI_0001646 a rdfs:Class ;
  rdfs:label "electron microscopy assay determining the 3D structure of a B cell epitope:antibody complex" ;
  rdfs:comment "An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a B cell epitope:antibody complex"@en ;
  rdfs:subClassOf obo:OBI_0001721 , obo:OBI_0003118 .

obo:OBI_1110131 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific proliferation of T cells" ;
  rdfs:comment "A T cell epitope dependent biological activity assay that detects T cell proliferation."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002055 .

obo:PATO_0000384 a rdfs:Class ;
  rdfs:label "male" ;
  rdfs:comment "A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes." ;
  rdfs:subClassOf obo:PATO_0001894 .

obo:OBI_0001736 a rdfs:Class ;
  rdfs:label "RIA measuring the association constant [KA] of a B cell epitope:antibody complex" ;
  rdfs:comment "A radio immuno assay that measures the association constant [KA] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000910 , obo:OBI_0001719 .

obo:OBI_0003323 a rdfs:Class ;
  rdfs:label "high throughput multiplexed assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope assay that measures the binding of an antibody receptor to an epitope using a high throughput multiplexed assay."@en ;
  rdfs:subClassOf obo:OBI_1110127 .

obo:GO_0002517 a rdfs:Class ;
  rdfs:label "T cell tolerance induction" ;
  rdfs:comment "A process involving any mechanism for tolerance induction in T cells." ;
  rdfs:subClassOf obo:GO_0002507 .

obo:OBI_0001639 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific Ig-mediated histamine release" ;
  rdfs:comment "A B cell epitope specific activation of additional immune response assay that detects histamine release in vitro."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001704 .

obo:OBI_0200029 a rdfs:Class ;
  rdfs:label "mean centering"@en ;
  rdfs:comment "A mean centering is a data transformation that takes as input an n-dimensional (real) vector, performs a mean calculation on its components, and subtracts the resulting mean from each component of the input."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_2100336 a rdfs:Class ;
  rdfs:label "manual differential bodily fluid basophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of basophils in bodily fluid as part of a manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003021 .

obo:OBI_0001804 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-7 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-7 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001587 , obo:OBI_0600031 .

obo:OBI_1110040 a rdfs:Class ;
  rdfs:label "infectious disease"@en ;
  rdfs:comment "is a disease caused by an infectious agent"@en ;
  rdfs:subClassOf obo:OGMS_0000031 .

obo:OBI_0000343 a rdfs:Class ;
  rdfs:label "inductive reasoning"@en ;
  rdfs:comment "a interpreting data that is used to ascribe properties or relations to types based on an observation instance (i.e., on a number of observations or experiences); or to formulate laws based on limited observations of recurring phenomenal patterns."@en ;
  rdfs:subClassOf obo:OBI_0000338 .

obo:OBI_0003035 a rdfs:Class ;
  rdfs:label "coma severity assay" ;
  rdfs:comment "A physical examination of an organism that has the objective to determine the severity of coma in a patient."@en ;
  rdfs:subClassOf obo:OBI_0002441 .

obo:GO_0016160 a rdfs:Class ;
  rdfs:label "amylase activity" ;
  rdfs:comment "Catalysis of the hydrolysis of amylose or an amylose derivative." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0003604 a rdfs:Class ;
  rdfs:label "multiplexed error-robust fluorescence in situ hybridization assay" ;
  rdfs:comment "A fluorescence in-situ hybridization assay that uses combinatorial FISH labeling with error resistant encoding schemes for highly multiplexed single-molecule imaging."@en ;
  rdfs:subClassOf obo:OBI_0003094 .

obo:OBI_1110008 a rdfs:Class ;
  rdfs:label "occurrence of infectious disease"@en ;
  rdfs:comment "Is an occurrence of a disease caused by an infection"@en ;
  rdfs:subClassOf obo:OGMS_0000063 .

obo:OBI_0002192 a rdfs:Class ;
  rdfs:label "Leica Peloris rapid tissue processor" ;
  rdfs:comment "An automatic tissue processor that is a dual retort tissue processor manufactured by the Leica company to provide fast, high quality tissue processing for histology laboratories."@en ;
  rdfs:subClassOf obo:OBI_0001064 .

obo:UBERON_0006314 a rdfs:Class ;
  rdfs:label "bodily fluid" ;
  rdfs:comment "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:OBI_0002610 a rdfs:Class ;
  rdfs:label "tongue swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of a tongue."@en ;
  rdfs:subClassOf obo:OBI_0002607 .

obo:IAO_8000019 a rdfs:Class ;
  rdfs:label "ontology module subsetted by OWL profile"@en ;
  rdfs:subClassOf obo:IAO_8000017 .

obo:OBI_0002707 a rdfs:Class ;
  rdfs:label "direct insecticide resistance diagnostic assay" ;
  rdfs:comment "A direct insecticide resistance assay that at preset insecticide dosage scoring mortality to determine resistance of a population."@en ;
  rdfs:subClassOf obo:OBI_0002705 .

obo:OBA_2060182 a rdfs:Class ;
  rdfs:label "lower limb coordination efficacy" ;
  rdfs:comment "The process efficacy of a lower limb coordination." ;
  rdfs:subClassOf obo:OBA_2060180 .

obo:OBI_2100101 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood eosinophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of eosinophils in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003023 , obo:OBI_0003040 .

obo:OBI_0003548 a rdfs:Class ;
  rdfs:label "upper limit of detection" ;
  rdfs:comment "A value specification that specifies the largest concentration/amount of a substance that can be quantified in an analyte assay."@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_0003738 a rdfs:Class ;
  rdfs:label "blood type assay" ;
  rdfs:comment "An assay that classifies an organism's blood within one or more blood group classification systems by identifying antigens present in the blood."@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0002151 a rdfs:Class ;
  rdfs:label "HCV antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to Hepacivirus C (HCV) antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0002548 a rdfs:Class ;
  rdfs:label "omentum specimen" ;
  rdfs:comment "A specimen that is derived from omentum."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001564 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a purified-MHC:ligand complex approximated by IC50" ;
  rdfs:comment "A radioactivity detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation and provides IC50 values determined under assay conditions where the IC50 approximates a KD value."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001568 , obo:OBI_0001989 .

obo:OBI_0003583 a rdfs:Class ;
  rdfs:label "cell viability assay" ;
  rdfs:comment "A cytometry assay which measures the number of living cells in a population."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:PATO_0000018 a rdfs:Class ;
  rdfs:label "fluorescence" ;
  rdfs:comment "A luminous flux quality inhering in a bearer by virtue of the bearer's emitting longer wavelength light following the absorption of shorter wavelength radiation; fluorescence is common with aromatic compounds with several rings joined together." ;
  rdfs:subClassOf obo:PATO_0001296 .

obo:OBI_0001693 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific tolerance induction" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that uses a tolerance induction intervention experiment."@en ;
  rdfs:subClassOf obo:OBI_0001488 , obo:OBI_0001698 .

obo:OBI_0001951 a rdfs:Class ;
  rdfs:label "reverse PCR primer"@en ;
  rdfs:comment "A short oligonucleotide complementary to target DNA (5'->3' on minus strand) that acts as the leader for DNA extension in a PCR reaction. The polymerase starts replication at the 3'-end of the primer, and copies the opposite strand. A primer is characterized by its 'melting temperature' (Tm) and pairs of primers should have similar Tm."@en ;
  rdfs:subClassOf obo:CHEBI_16991 , obo:OBI_0001879 .

obo:OBI_0000511 a rdfs:Class ;
  rdfs:label "injector lubricant" ;
  rdfs:comment "A lubricant used in liquid chromatography that eases sample injector penetration."@en ;
  rdfs:subClassOf obo:OBI_0000601 .

obo:OBI_0000143 a rdfs:Class ;
  rdfs:label "baseline participant role"@en ;
  rdfs:comment "a reference participant role which is realized by making the reference to qualities at the start of the study or intervention"@en ;
  rdfs:subClassOf obo:OBI_0000220 .

obo:OBI_0002682 a rdfs:Class ;
  rdfs:label "glass bottle coated with insecticides" ;
  rdfs:comment "A glass bottle that coated with material designed to control insects."@en ;
  rdfs:subClassOf obo:OBI_0002681 .

obo:OBI_0000943 a rdfs:Class ;
  rdfs:label "chemical cleavage" ;
  rdfs:comment "chemical cleavage is a protocol application relying on a chemical compound to cause the fragmentation of an input material that is susceptible to that chemical agent"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000559 a rdfs:Class ;
  rdfs:label "liquid NMR probe" ;
  rdfs:comment "An NMR probe that is designed to hold a liquid sample."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_0001978 a rdfs:Class ;
  rdfs:label "immunoblot assay" ;
  rdfs:comment "An analyte assay that detects specific molecules in an input material by separating it using gel electrophoresis, transfering the separated molecules to a membrane, and staining them with_ antibodies specific to the analyte molecules."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000406 a rdfs:Class ;
  rdfs:label "PCR product"@en ;
  rdfs:comment "is double stranded DNA that is the specified output of a polymerase chain reaction"@en ;
  rdfs:subClassOf obo:CHEBI_4705 , obo:OBI_0000809 .

obo:PATO_0001233 a rdfs:Class ;
  rdfs:label "dorsal to" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity." ;
  rdfs:subClassOf obo:PATO_0000140 .

obo:CHEBI_17544 a rdfs:Class ;
  rdfs:label "hydrogencarbonate" ;
  rdfs:comment "The carbon oxoanion resulting from the removal of a proton from carbonic acid." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000682 a rdfs:Class ;
  rdfs:label "obsolete_study result" ;
  rdfs:comment "Study result is an information content entity  that is a specified data output of a study."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000375 a rdfs:Class ;
  rdfs:label "freeze function"@en ;
  rdfs:comment "A freeze function is a function to decrease the internal kinetic energy of a material below the freezing point of that type of material."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:CHEBI_39027 a rdfs:Class ;
  rdfs:label "very-low-density lipoprotein" ;
  rdfs:comment "A class of lipoproteins of large size (30-80 nm), very low density (0.93-1.006 g/ml) particles with a core composed mainly of triglycerides and a surface monolayer of phospholipids and cholesterol into which are imbedded the apolipoproteins B, E, and C. VLDL facilitate the transport of endogenously made triglycerides to extrahepatic tissues." ;
  rdfs:subClassOf obo:CHEBI_6495 .

obo:OBI_0000112 a rdfs:Class ;
  rdfs:label "specimen role"@en ;
  rdfs:comment "A role borne by a material entity that is obtained during a specimen collection process and that can be realized by performing measurements or observations on the specimen."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_2100112 a rdfs:Class ;
  rdfs:label "lipid panel venous blood triglyceride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of triglyceride in venous blood as part of a lipid panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100029 .

obo:OBI_0400137 a rdfs:Class ;
  rdfs:label "cytometer" ;
  rdfs:comment "A cytometer is an instrument for counting and/or measuring characteristics of cells."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0600045 a rdfs:Class ;
  rdfs:label "3D structure determination assay" ;
  rdfs:comment "An assay that determines the 3-dimensional configuration of an input material."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:CL_0000081 a rdfs:Class ;
  rdfs:label "blood cell" ;
  rdfs:comment "A cell found predominately in the blood." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0002543 a rdfs:Class ;
  rdfs:label "atrial appendage specimen" ;
  rdfs:comment "A specimen that is derived from the atrium auricular region."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001360 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-6 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-6 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001451 , obo:OBI_0003115 .

obo:OBI_0400100 a rdfs:Class ;
  rdfs:label "syringe pump" ;
  rdfs:comment "Part of the fluidics system. A syringe pump can be used to inject the sample fluid and cells into the sheath fluid in the flow chamber. Syringe pumps are useful for creating stable flow rates."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0002531 a rdfs:Class ;
  rdfs:label "cortex of kidney specimen" ;
  rdfs:comment "A specimen that is derived from cortex of kidney."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002805 a rdfs:Class ;
  rdfs:label "transparent droplet barrier" ;
  rdfs:comment "A device which is a transparent constructed barrier, usually made out of acrylic (Plexiglass) or polycarbonate plastic, installed in facilities to intercept respiratory droplets, encourage physical distancing requirements."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001815 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-18 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-18 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001380 .

obo:OBI_0001884 a rdfs:Class ;
  rdfs:label "specimen-based scope of investigation specification"@en ;
  rdfs:comment "A plan specification which specifies the scope of an investigation based on the heterogeneity of organisms or type of material that are the specified input of specimen collection."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0001720 a rdfs:Class ;
  rdfs:label "B cell epitope specific immune complex formation" ;
  rdfs:comment "immune complex formation resulting from antibody binding to epitope"@en ;
  rdfs:subClassOf obo:GO_0097281 , obo:OBI_0001702 .

obo:OBI_2100229 a rdfs:Class ;
  rdfs:label "chem11 venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:GO_0004104 a rdfs:Class ;
  rdfs:label "cholinesterase activity" ;
  rdfs:comment "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0600026 a rdfs:Class ;
  rdfs:label "longitudinal mass measurement assay" ;
  rdfs:comment "An assay that measures the mass of a material at two or more time points"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003366 a rdfs:Class ;
  rdfs:label "organism diagnostic process"@en ;
  rdfs:comment "A drawing a conclusion based on data that involves the interpretation of data about a given organism (human, animal, or plant) and the assertion to the effect that the organism has or had a disease, disorder, or syndrome of a certain type, or none of these as output."@en ;
  rdfs:subClassOf obo:OBI_0000338 .

obo:OBI_0003763 a rdfs:Class ;
  rdfs:label "ovulation assessment in rodent assay" ;
  rdfs:comment "A histological assay that measures the number of corpora lutea (UBERON:0002512) in the ovary of an organism; corpora lutea develop from the postovulatory follicle."@en ;
  rdfs:subClassOf obo:OBI_0600020 .

obo:OBI_0003836 a rdfs:Class ;
  rdfs:label "neuron burst duration assay" ;
  rdfs:comment "An electrophysiology assay that measures the time elapsed between the first action potential in a neuron burst and the last in that burst."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0002176 .

obo:OBI_0000895 a rdfs:Class ;
  rdfs:label "total RNA extract" ;
  rdfs:comment "A RNA extract that is the output of an extraction process in which total celluar and organelle RNA molecules are isolated from a specimen."@en ;
  rdfs:subClassOf obo:OBI_0000880 .

obo:UBERON_0002530 a rdfs:Class ;
  rdfs:label "gland" ;
  rdfs:comment "An organ that functions as a secretory or excretory organ." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0002621 a rdfs:Class ;
  rdfs:label "reconstitution assay" ;
  rdfs:comment "An assay in which a cellular process is replicated from the bottom-up using isolated components in order to observe how the components work together."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0000471 .

obo:OBI_0001388 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-1 alpha production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001097 a rdfs:Class ;
  rdfs:label "liquid extraction robot" ;
  rdfs:comment "A liquid handling device that provides automatic liquid extraction."@en ;
  rdfs:subClassOf obo:OBI_0400112 .

obo:OBI_0001203 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects transforming growth factor-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001264 .

obo:OBI_0003436 a rdfs:Class ;
  rdfs:label "N-acetyl-beta-glucosaminidase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of N-acetyl-beta-glucosaminidase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_0002114 a rdfs:Class ;
  rdfs:label "bromouridine pulse-chase and sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay used to identify RNA populations of specific ages through isolation of RNAs first labelled with bromouridine (Bru) followed by chasing in uridine for different periods of time."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0002502 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid specimen" ;
  rdfs:comment "A specimen that is derived from cerbrospinal fluid."@en ;
  rdfs:subClassOf obo:OBI_2000009 .

obo:OBI_0001661 a rdfs:Class ;
  rdfs:label "chromatography assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An analytical chromatography assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001630 , obo:OBI_0001703 .

obo:OBI_0001423 a rdfs:Class ;
  rdfs:label "intracellular material detection measuring epitope specific granzyme B release by T cells" ;
  rdfs:comment "A flow cytometry assay that detects epitope specific granzyme B release by T cells"@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001436 .

obo:OBI_0001010 a rdfs:Class ;
  rdfs:label "nucleic acid extract" ;
  rdfs:comment "An extract that is the output of an extraction process in which nucleic acid molecules are isolated from a specimen."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0002435 a rdfs:Class ;
  rdfs:label "exposure to blood borne infectious disease exclusion criterion" ;
  rdfs:comment "An exclusion criterion defined  as whether an individual has been exposed to a blood borne infections disease through needle sticks and/or contact with non-intact skin and/or contact with open wounds and/or contact with mucous membranes, which if met, makes the individual unsuitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500028 .

obo:NCBITaxon_10116 a rdfs:Class ;
  rdfs:label "Rattus norvegicus" ;
  rdfs:subClassOf obo:NCBITaxon_39107 .

obo:OBI_0003543 a rdfs:Class ;
  rdfs:label "microarray assay measuring NS1" ;
  rdfs:comment "A microarray assay that detects NS1."@en ;
  rdfs:subClassOf obo:OBI_0001985 , obo:OBI_2100023 .

obo:OBI_2100195 a rdfs:Class ;
  rdfs:label "GEM premier blood gas venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood as part of a GEM premier blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0002979 a rdfs:Class ;
  rdfs:label "reference protein sequence start site" ;
  rdfs:comment "The position of the first amino acid in a reference protein sequence (sequence being used for comparison)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001829 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects chemokine (C-C motif) ligand 1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001276 , obo:OBI_0600031 .

obo:GO_0005739 a rdfs:Class ;
  rdfs:label "mitochondrion" ;
  rdfs:comment "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." ;
  rdfs:subClassOf obo:GO_0043227 .

obo:OBI_0001269 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific cytotoxic T cell degranulation" ;
  rdfs:comment "A T cell epitope dependent biological activity assay that detects cytotoxic T cell degranulation."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002055 .

obo:OBI_0002779 a rdfs:Class ;
  rdfs:label "mid-turbinate nasal swab specimen" ;
  rdfs:comment "A specimen that is collected with a mid-turbinate nasal swab from the turbinate area of the nasal cavity."@en ;
  rdfs:subClassOf obo:OBI_0000917 .

obo:OBI_0001005 a rdfs:Class ;
  rdfs:label "RNASE CL3 structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAse CL3 as reagent and enzymatic probe."@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:OBI_0000425 a rdfs:Class ;
  rdfs:label "averaging objective"@en ;
  rdfs:comment "An averaging objective is a data transformation objective where the aim is to perform mean calculations on the input of the data transformation."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0200110 a rdfs:Class ;
  rdfs:label "s transformation"@en ;
  rdfs:comment "An s transformation is a data transformation obtained by applying the function S described in what follows to a (one dimensional) real number input. S(x)=T*exp(w-m)*(exp(x-w)-(p^2)*exp((w-x)/p)+p^2-1) if x>=w, S(x)=-S(w-x) otherwise; where exp denotes an exponential_transformations, 'p^' denotes the exponential transformation with base p; T, w, m, p are real constants with T, m, and p positive and w non-negative, and where w and p are related by w=2p*ln(p)(p+1) with the objective of normalization."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_2100184 a rdfs:Class ;
  rdfs:label "vented blood gas arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a vented blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:OBI_0000656 a rdfs:Class ;
  rdfs:label "data set of predicted values according to fitted curve"@en ;
  rdfs:comment "A data set which is the output of a curve fitting data transformation in which the aim is to find a curve which matches a series of data points and possibly other constraints."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:OBI_0002043 a rdfs:Class ;
  rdfs:label "individual-nucleotide resolution cross-linking and immunoprecipitation sequencing assay" ;
  rdfs:comment "A cross-linking immunoprecipitation high-throughput sequencing assay that identifies protein-RNA interactions using UV light to covalently bind proteins and RNA molecules, allowing for a very stringent purification of the linked protein-RNA complexes."@en ;
  rdfs:subClassOf obo:OBI_0001858 .

obo:OBI_0001166 a rdfs:Class ;
  rdfs:label "validation by real time PCR design" ;
  rdfs:comment "a study design in which the accuracy or the quality of the result of an assay is checked by comparing with real time PCR results"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001844 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-12 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001391 , obo:OBI_0600031 .

obo:OBI_2100202 a rdfs:Class ;
  rdfs:label "arterial blood lactic acid assay" ;
  rdfs:comment "An assay that measures lactic acid in arterial blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100042 .

obo:OBI_0001725 a rdfs:Class ;
  rdfs:label "B cell epitope specific histamine secretion mediated by immunoglobulin" ;
  rdfs:comment "histamine secretion mediated by immunoglobulin resulting from antibody binding to epitope"@en ;
  rdfs:subClassOf obo:GO_0097280 .

obo:OBI_0600037 a rdfs:Class ;
  rdfs:label "cell culture splitting"@en ;
  rdfs:comment "The act of taking part of a homogeneous cell culture and creating one or more additional separate cultures of similar qualities. input: cell_culture, output cell_culture min cardinality 2. part of cell culturing"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0001877 a rdfs:Class ;
  rdfs:label "random access memory"@en ;
  rdfs:comment "Random-access memory (RAM) is a form of computer data storage. A random-access device allows stored data to be accessed directly in any random order. In contrast, other data storage media such as hard disks, CDs, DVDs and magnetic tape, as well as early primary memory types such as drum memory, read and write data only in a predetermined order, consecutively, because of mechanical design limitations. Therefore, the time to access a given data location varies significantly depending on its physical location"@en ;
  rdfs:subClassOf obo:IAO_0000178 .

obo:OBI_0002008 a rdfs:Class ;
  rdfs:label "Mouse 385K Whole Genome CGH Tiling Array" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for mouse DNA against 385,000 features."@en ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_2100210 a rdfs:Class ;
  rdfs:label "SPEP protein electrophoresis venous blood protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in venous blood as part of a SPEP protein electrophoresis order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0003087 a rdfs:Class ;
  rdfs:label "autofluorescence assay" ;
  rdfs:comment "A fluorescence detection assay in which the light that is naturally emitted by a sample is visualized after excitation of the sample with light at a suitable wavelength."@en ;
  rdfs:subClassOf obo:OBI_0001501 .

obo:OBI_0002145 a rdfs:Class ;
  rdfs:label "antigen specific antibodies assay" ;
  rdfs:comment "An analyte assay that measures the presence or amount of antibodies to a specified antigen."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002405 a rdfs:Class ;
  rdfs:label "hormonal replacement therapy history" ;
  rdfs:comment "A clinical history in which an individual has had hormonal replacement therapy in the past."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0003484 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-25 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-25 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0003637 a rdfs:Class ;
  rdfs:label "antibody purification of cattle MHC class II protein complex" ;
  rdfs:comment "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class II protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003636 .

obo:OBI_0003903 a rdfs:Class ;
  rdfs:label "count of multi-electrode plate electrodes detecting action potential assay" ;
  rdfs:comment "A multi-electrode array assay that measures the number of electrodes in a well where the mean rate of action potentials is at least 5 spikes per minute."@en ;
  rdfs:subClassOf obo:OBI_0003901 .

obo:GO_0047823 a rdfs:Class ;
  rdfs:label "D-glutamyltransferase activity" ;
  rdfs:comment "Catalysis of the reaction: D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4+. Can also transfer additional glutamyl residues to a peptide, extending the polypeptide chain." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0003064 a rdfs:Class ;
  rdfs:label "organism detection datum" ;
  rdfs:comment "A data item that is the specified output of an organism detection assay."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0400047 a rdfs:Class ;
  rdfs:label "gas laser" ;
  rdfs:comment "A gas laser is a laser in which the lasing medium is a gas. The laser medium is places between two parallel mirrors for light emission amplification. The gas is excited to emit light via an external light source or an electric current discharging through the gas."@en ;
  rdfs:subClassOf obo:OBI_0400064 .

obo:OBI_0200167 a rdfs:Class ;
  rdfs:label "data normalization objective"@en ;
  rdfs:comment """A normalization objective is a data transformation objective where the aim is to remove
systematic sources of variation to put the data on equal footing in order
to create a common base for comparisons."""@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0302716 a rdfs:Class ;
  rdfs:label "pool of specimens" ;
  rdfs:comment "A pool of specimens is a mixture of a population of samples which have been gathered from one or more sample populations, obtained by the physical process of mixing individual specimens, e.g.  mixing the DNA collected from the individual fish."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0003377 a rdfs:Class ;
  rdfs:label "single-nucleus chromatin accessibility and mRNA expression sequencing 2 assay" ;
  rdfs:comment "An assay that uses combinatorial indexing to generate a library of cDNA and open chromatin gDNA fragments by tagmenting a single nuclei and open chromatin, and encapsulating those in a droplet including both an oligo-dT-containing barcoded bead and a splint oligonucleotide, which links the tagmented gDNA fragments to the bead which capture both mRNAs and open chromatin fragments."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000607 a rdfs:Class ;
  rdfs:label "high resolution magic angle spin probe" ;
  rdfs:comment "Samples that are neither solid nor liquid, being of biological, chemical, or pharmaceutical interest, reveal highly resolved spectra when magic angle spinning is applied. The correct solution is a gradient, such that the field varies along the spinner axis. This so-called Magic Angle Gradient is employed in Brukers high resolution Magic Angle Spinning (hr-MAS) probes, and is implemented in such a way that it is compatible with the stator and does not interfere with the sample eject or insert. Bruker BioSpin has developed a series of dedicated probes for standard bore magnets to accommodate the rapidly expanding field of hr-MAS. These probes are available in double (e.g. 1H and 13C) and triple resonance (e.g. 1H, 13C, 15N) modes and come equipped with a deuterium lock channel. The probes have automatic sample ejection and insertion capability, with the availability of an optional sample changer, enabling fully automated sample runs. Probes can be equipped with an optional B0 gradient, directed along the magic angle, so that gradient spectroscopy can be done used."@en ;
  rdfs:subClassOf obo:OBI_0000480 .

obo:OBI_0002398 a rdfs:Class ;
  rdfs:label "hysterectomy history" ;
  rdfs:comment "A gynecologic surgery history in which a woman has had a hysterectomy."@en ;
  rdfs:subClassOf obo:OBI_0002397 .

obo:GO_0032640 a rdfs:Class ;
  rdfs:label "tumor necrosis factor production" ;
  rdfs:comment "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." ;
  rdfs:subClassOf obo:GO_0071706 .

obo:OBI_0001499 a rdfs:Class ;
  rdfs:label "binding assay using fluorescence detection" ;
  rdfs:comment "A binding assay that uses fluorescence detection as an indicator of binding."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0003651 a rdfs:Class ;
  rdfs:label "multidimensional fatigue inventory score"@en ;
  rdfs:comment "A clinical data item that quantifies the severity of a person's fatigue as measured by a 20-item self-report instrument."@en ;
  rdfs:subClassOf obo:OGMS_0000123 .

obo:OBI_0000231 a rdfs:Class ;
  rdfs:label "enzymatic cleavage"@en ;
  rdfs:comment "a material processing that digests the fraction of input material that is susceptible to that enzyme"@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0001419 a rdfs:Class ;
  rdfs:label "ChIP-chip by tiling array assay" ;
  rdfs:comment "A ChIP-ChIP assay in which immunoprecipitated chromatin is run on a tiling array that covers stretches of DNA to to detect which elements in those stretches are present in the isolated chromatin"@en ;
  rdfs:subClassOf obo:OBI_0001248 .

obo:OBI_0000997 a rdfs:Class ;
  rdfs:label "growth environment" ;
  rdfs:comment "The collection of material entities and their qualities that are located near a live organism, tissue or cell and can influence its growth."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0666666 a rdfs:Class ;
  rdfs:label "RNA extraction"@en ;
  rdfs:comment "A RNA extraction is a nucleic acid extraction where the desired output material is RNA"@en ;
  rdfs:subClassOf obo:OBI_0666667 .

obo:OBI_0200126 a rdfs:Class ;
  rdfs:label "network graph construction"@en ;
  rdfs:comment "A network analysis in which an input data set describing objects and relationships between objects is transformed into an output representation of these objects as nodes and the relationships as edges of a network graph."@en ;
  rdfs:subClassOf obo:OBI_0200080 .

obo:OBI_0000552 a rdfs:Class ;
  rdfs:label "reverse transcribed polymerase chain reaction" ;
  rdfs:comment "reverse transcribe pcr is a process which allow amplification of cDNA during a pcr reaction while the cDNA results from a retrotranscription of messenger RNA isolated from a material entity."@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBI_0003778 a rdfs:Class ;
  rdfs:label "hormone assay" ;
  rdfs:comment "The analyte assay that measures the abundance of a hormone in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:CHEBI_50076 a rdfs:Class ;
  rdfs:label "chromium-51" ;
  rdfs:comment "A synthetic radioactive isotope of chromium having a half-life of 27.7 days and decaying by electron capture with emission of γ rays (0.32 MeV); it is used to label red blood cells for measurement of mass or volume, survival time, and sequestration studies, for the diagnosis of gastrointestinal bleeding, and to label platelets to study their survival." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003211 a rdfs:Class ;
  rdfs:label "nitrite concentration assay" ;
  rdfs:comment "A nitrite assay that measures the concentration of nitrite in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003210 .

obo:OBI_0001258 a rdfs:Class ;
  rdfs:label "ChIP-seq design" ;
  rdfs:comment "A study design which aims to identify protein and DNA interactions using a combination of chromatin immunoprecipitation and high throughput sequencing. Massively parallel sequence analyses are used in conjunction with whole-genome sequence databases to analyze the interaction pattern of any protein with DNA, or the pattern of any epigenetic chromatin modifications."@en ;
  rdfs:subClassOf obo:OBI_0001425 .

obo:CHEBI_39124 a rdfs:Class ;
  rdfs:label "calcium ion" ;
  rdfs:subClassOf obo:COB_0000013 .

obo:GO_0097282 a rdfs:Class ;
  rdfs:label "immunoglobulin-mediated neutralization" ;
  rdfs:comment "The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin." ;
  rdfs:subClassOf obo:GO_0016064 .

obo:UO_0000060 a rdfs:Class ;
  rdfs:label "speed/velocity unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:OBI_0001219 a rdfs:Class ;
  rdfs:label "epitope specific chemokine (C-C motif) ligand 1 production by T cells" ;
  rdfs:comment "A process of chemokine (C-C motif) ligand 1 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071610 , obo:OBI_0001193 .

obo:OBI_0000825 a rdfs:Class ;
  rdfs:label "to be treated with placebo role" ;
  rdfs:comment "A study subject role which begins to exist when a subject is assigned to be one of those who will receive a placebo, and realized in a study execution in which they receive the placebo"@en ;
  rdfs:subClassOf obo:OBI_0000097 .

obo:OBI_0001310 a rdfs:Class ;
  rdfs:label "species comparison design" ;
  rdfs:comment "A study design that assays differences between distinct species."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001850 a rdfs:Class ;
  rdfs:label "transcript analysis by paired-end tag sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that employs paired-end sequencing of RNA transcripts to determine things such as gene expression, gene structure, and alternative transcript structure."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_2100296 a rdfs:Class ;
  rdfs:label "ABL90 panel venous blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in venous blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_0003335 a rdfs:Class ;
  rdfs:label "diffusion weighted magnetic resonance image data set" ;
  rdfs:comment "A type of magnetic resonance image data set collected using at least three diffusion gradients of some factor \"b,\" which is a function of the amplitude, duration, and interval of the gradiants."@en ;
  rdfs:subClassOf obo:OBI_0003334 .

obo:OBI_0002585 a rdfs:Class ;
  rdfs:label "sequence trimming" ;
  rdfs:comment "A data transformation in which subsequences of a molecular sequence are cut (removed)."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_0001456 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific macrophage inflammatory protein-1 gamma production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects macrophage inflammatory protein-1 gamma production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0400041 a rdfs:Class ;
  rdfs:label "FACSvantage" ;
  rdfs:comment "The FACSvantage is a flow_cytometer_sorter manufactured by Becton Dickinson. It has analog electronics, three lasers (several options are available), and the filters and PMTs to collect 6 fluorescent parameters and side scatter, and a photodiode to collect forward scatter. The FACSvantage can be used to analyse, sort and collect cells."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0002490 a rdfs:Class ;
  rdfs:label "medication time value specification" ;
  rdfs:comment "A scalar value specification that specifies the point in time that a human participant under investigation self-administers a medication material"@en ;
  rdfs:subClassOf obo:OBI_0001931 .

obo:OBI_0001408 a rdfs:Class ;
  rdfs:label "imprinting design" ;
  rdfs:comment "A study design where differences in genetic imprinting of maternally- and paternally-inherited chromosomes (e.g., due to in vivo differences in chemical modification and/or chromatin structure) are compared."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0600058 a rdfs:Class ;
  rdfs:label "enzymatic amplification"@en ;
  rdfs:comment "the use of enzymes to increase the number of molecules of a biomaterial"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003403 a rdfs:Class ;
  rdfs:label "Affymetrix Mouse Exon Junction Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, used to identify exon-exon junctions associated with alternate splice variants in the mouse transcriptome."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0002975 a rdfs:Class ;
  rdfs:label "input protein sequence start site" ;
  rdfs:comment "The position of the first amino acid in a protein sequence being analyzed (input protein sequence)."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:NCBITaxon_7955 a rdfs:Class ;
  rdfs:label "Danio rerio" ;
  rdfs:subClassOf obo:NCBITaxon_117571 .

obo:UBERON_0005023 a rdfs:Class ;
  rdfs:label "mucosa of oropharynx" ;
  rdfs:comment "A mucosa that is part of a oropharynx [Automatically generated definition]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0002661 a rdfs:Class ;
  rdfs:label "tail biopsy" ;
  rdfs:comment "A biopsy involving the collection of the tip of a mamallian tail."@en ;
  rdfs:subClassOf obo:OBI_0002650 .

obo:OBI_0003176 a rdfs:Class ;
  rdfs:label "free thyroxine concentration assay" ;
  rdfs:comment "A thyroxine assay that measures the concentration of free thyroxine in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100035 .

obo:OBI_0001386 a rdfs:Class ;
  rdfs:label "epitope specific monocyte chemotactic protein-1 production by T cells" ;
  rdfs:comment "A process of monocyte chemotactic protein-1 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071605 , obo:OBI_0001193 .

obo:OBI_0200175 a rdfs:Class ;
  rdfs:label "class discovery data transformation"@en ;
  rdfs:comment "A class discovery data transformation (sometimes called unsupervised classification) is a data transformation that has objective class discovery."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0003626 a rdfs:Class ;
  rdfs:label "antibody purification of rat MHC class I protein complex" ;
  rdfs:comment "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of rat MHC class I protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003616 .

obo:OBI_0002120 a rdfs:Class ;
  rdfs:label "mixed lymphocyte reaction assay" ;
  rdfs:comment "A cytometry assay where lymphocytes from two individuals are co-cultured with the lymphocytes from one of the allogeneic individuals (Responders) being labeled (with 3H Thymidine or BrdU) and the proliferation of the labeled cells is measured, which is thought to reflect recognition of histocompatibility antigens on the unlabeled cells (stimulators)."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002643 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells based on tumor burden" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from tumor challenge resulting from the adoptive transfer of epitope specific T cells using tumor burden."@en ;
  rdfs:subClassOf obo:OBI_0001473 , obo:OBI_0003472 .

obo:PATO_0000125 a rdfs:Class ;
  rdfs:label "mass" ;
  rdfs:comment "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0000220 a rdfs:Class ;
  rdfs:label "reference subject role"@en ;
  rdfs:comment "a reference subject  role which inheres in an organism or entity of organismal origin so that the characteristics or responses of the participant playing the reference participant role are used for comparison or reference"@en ;
  rdfs:subClassOf obo:OBI_0000097 .

obo:OBI_2100241 a rdfs:Class ;
  rdfs:label "chem16 venous blood triglyceride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of triglyceride in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100029 .

obo:OBI_0000986 a rdfs:Class ;
  rdfs:label "obsolete_DNA sequencing training service" ;
  rdfs:comment "A training process with the objective to provide a trainee with the skill to run DNA sequencing experiments"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0002603 a rdfs:Class ;
  rdfs:label "areolar swab specimen" ;
  rdfs:comment "A specimen that is collected with a swab from the surface of an areola of a breast."@en ;
  rdfs:subClassOf obo:OBI_0002604 .

obo:IAO_0000300 a rdfs:Class ;
  rdfs:label "textual entity"@en ;
  rdfs:comment "A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003265 a rdfs:Class ;
  rdfs:label "eukaryota in feces datum" ;
  rdfs:comment "A feces microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003246 .

obo:OBI_2100207 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood myelocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of myelocytes in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_0003165 .

obo:OBI_0002462 a rdfs:Class ;
  rdfs:label "ERCC RNA spike-in" ;
  rdfs:comment "A processed material developed by the External RNA Controls Consortium (ERCC) that  consists of 92 transcripts, derived and traceable from NIST-certified DNA plasmids."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0000273 a rdfs:Class ;
  rdfs:label "role of regulator of consumables and medical devices"@en ;
  rdfs:comment "a regulator involved with making and enforcing legislation and governmental orders relevant to the development, testing, manufacture and use of food, drugs and medical devices"@en ;
  rdfs:subClassOf obo:OBI_0000014 .

obo:OBI_0001075 a rdfs:Class ;
  rdfs:label "hybridization oven" ;
  rdfs:comment "A device that creates an appropriate environment for nucleic acid hybridization."@en ;
  rdfs:subClassOf obo:OBI_0000136 , obo:OBI_0002089 .

obo:OBI_0001462 a rdfs:Class ;
  rdfs:label "epitope specific IP-10 production by T cells" ;
  rdfs:comment "A process of IP-10 production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071612 , obo:OBI_0001193 .

obo:OBI_0001553 a rdfs:Class ;
  rdfs:label "assay measuring a binding constant of a MHC:ligand complex" ;
  rdfs:comment "A MHC:ligand binding assay that measures a binding constant."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003145 .

obo:OBI_0001032 a rdfs:Class ;
  rdfs:label "light emission device" ;
  rdfs:comment "A device which has a function to emit light."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000836 a rdfs:Class ;
  rdfs:label "test tube" ;
  rdfs:comment "A test tube is a device consisting of a glass or plastic tubing, open at the top, usually with a rounded U-shaped bottom which has the function to contain material"@en ;
  rdfs:subClassOf obo:OBI_0000522 .

obo:OBI_0000541 a rdfs:Class ;
  rdfs:label "Bruker AC series NMR instrument" ;
  rdfs:comment "A series of older Bruker NMR magnets, now out of production."@en ;
  rdfs:subClassOf obo:OBI_0000596 .

obo:OBI_0002677 a rdfs:Class ;
  rdfs:label "in vivo assay measuring a B cell epitope specific response after adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that is performed after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001698 .

obo:GO_0001046 a rdfs:Class ;
  rdfs:label "core promoter sequence-specific DNA binding" ;
  rdfs:comment "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." ;
  rdfs:subClassOf obo:GO_0003674 , obo:GO_0043565 .

obo:CHEBI_33709 a rdfs:Class ;
  rdfs:label "amino acid" ;
  rdfs:comment "A carboxylic acid containing one or more amino groups." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_2000002 a rdfs:Class ;
  rdfs:label "cervical mucus specimen" ;
  rdfs:comment "A specimen that is derived from some cervical mucus"@en ;
  rdfs:subClassOf obo:OBI_0001479 , obo:OBI_2000009 .

obo:OBI_0002069 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific perforin release by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects epitope specific perforin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001497 , obo:OBI_0600031 .

obo:GO_0019814 a rdfs:Class ;
  rdfs:label "immunoglobulin complex" ;
  rdfs:comment "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." ;
  rdfs:subClassOf obo:GO_0032991 .

obo:OBI_0400118 a rdfs:Class ;
  rdfs:label "vortexer" ;
  rdfs:comment "A vortexer is an instrument that mixes small vials of liquid by creating a rotation of the liquid around its own center. It consists of an electric motor with the drive shaft oriented vertically and attached to a cupped rubber piece mounted slightly off-center. As the motor runs the rubber piece oscillates rapidly in a circular motion. When a test tube or other appropriate container is pressed into the rubber cup (or touched to its edge) the motion is transmitted to the liquid inside and a vortex is created."@en ;
  rdfs:subClassOf obo:OBI_0001033 .

obo:OBI_0000930 a rdfs:Class ;
  rdfs:label "calorimeter" ;
  rdfs:comment "A measurement device that is used to calculate the heat flow of a chemical reaction or physical change."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001962 a rdfs:Class ;
  rdfs:label "target gene specification"@en ;
  rdfs:comment "is a directive information specifying a coding genomic region which is the focus of a planned process such as an assay, for instance in a environmental gene survey"@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0001891 a rdfs:Class ;
  rdfs:label "sequencing facility organization"@en ;
  rdfs:comment "An organization that provides sequence determination service"@en ;
  rdfs:subClassOf obo:OBI_0000245 , obo:OBI_0002198 .

obo:OBI_0002021 a rdfs:Class ;
  rdfs:label "Illumina NextSeq 500" ;
  rdfs:comment "A DNA sequencer which is a desktop sequencer ideal for smaller-scale studies manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology."@en ;
  rdfs:subClassOf obo:OBI_0003684 .

obo:OBI_0003910 a rdfs:Class ;
  rdfs:label "urea nitrogen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of urea nitrogen."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003689 a rdfs:Class ;
  rdfs:label "ice bath" ;
  rdfs:comment "A temperature control bath in which a water ice mixture acts as contact medium at constant temperature of 0 degrees Celsius or below if salt solutions are used."@en ;
  rdfs:subClassOf obo:OBI_0400120 .

obo:OBI_0600047 a rdfs:Class ;
  rdfs:label "sequencing assay" ;
  rdfs:comment "An assay the uses chemical or biochemical means to infer the sequence of a biomaterial"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0003842 a rdfs:Class ;
  rdfs:label "tissue mass assay" ;
  rdfs:comment "A mass measurement assay with evaluant tissue or bodily fluid specimen."@en ;
  rdfs:subClassOf obo:OBI_0000445 .

obo:OBI_0003796 a rdfs:Class ;
  rdfs:label "pathogen neutralization assay" ;
  rdfs:comment "An assay that measures neutralization of a pathogen."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000693 a rdfs:Class ;
  rdfs:label "MeDIP-seq assay" ;
  rdfs:comment "A DNA methylation profiling assay that identifies methylated sites in genomic DNA and determines the methylation pattern that affect gene transcription using immunoprecipitation of methylated genomic DNA, creation of a library of corresponding DNA fragments (either single or paired-end fragments) and subsequent sequencing using parallelized sequencing methods."@en ;
  rdfs:subClassOf obo:OBI_0000634 , obo:OBI_0001954 , obo:OBI_0600047 .

obo:OBI_0003509 a rdfs:Class ;
  rdfs:label "rapid alternating hands assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to alternate the forearm between pronation and suppination as quickly as possible during a specified duration of time"@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0003922 a rdfs:Class ;
  rdfs:label "PacBio Revio" ;
  rdfs:comment "A DNA sequencer that is manufactured by the Pacific Biosciences corporation, built upon single molecule real-time sequencing technology, that uses SMRT Cell 25M flow cells to generate highly accurate (\"HiFi\") long reads at high throughput."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_2100162 a rdfs:Class ;
  rdfs:label "venous blood creatine kinase MB assay" ;
  rdfs:comment "An assay that measures creatine kinase MB in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100041 .

obo:OBI_0000213 a rdfs:Class ;
  rdfs:label "fluorescence compensation matrix"@en ;
  rdfs:comment "A fluorescence compensation matrix is a square matrix which is used as the left multiplier of the vector of fluorescence values while performing digital fluorescence compensation. Also, fluorescence compensation matrix is the inverse of the fluorescence spillover matrix."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_2100344 a rdfs:Class ;
  rdfs:label "vitamin B12 and Folate venous blood folic acid assay" ;
  rdfs:comment "An analyte assay that measures the abundance of folic acid in venous blood as part of a vitamin B12 and Folate order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100037 .

obo:CL_0000233 a rdfs:Class ;
  rdfs:label "platelet" ;
  rdfs:comment "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." ;
  rdfs:subClassOf obo:CL_0000081 .

obo:OBI_0600041 a rdfs:Class ;
  rdfs:label "concentrate"@en ;
  rdfs:comment "a protocol application to create an output material with an increased density of a material of interest that is part of the input material by separating other parts of the input material"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0003356 a rdfs:Class ;
  rdfs:label "raw magnetic resonance image data set reconstruction" ;
  rdfs:comment "A process that transforms raw magnetic resonance image data from an NMR/MRI machine into a reconstructed magnetic resonance image data set."@en ;
  rdfs:subClassOf obo:OBI_0003355 .

obo:OBI_0001703 a rdfs:Class ;
  rdfs:label "assay measuring qualitative binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An assay that detects the binding of an antigen with an antibody, and produces a qualitative measurement of the binding as an output."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110127 .

obo:OBI_0400075 a rdfs:Class ;
  rdfs:label "MoFlo" ;
  rdfs:comment "A MoFlo is a flow_cytometer_sorter manufactured by Dako Cytomation. It features digital electronics, the option to include several lasers (solid state 488 nm, 635 nm, and a 351 nm diode laser), and has the filtering and collection capacity for up to 10 flouresecent parameters. The MoFlo is an instrument that can be used to both analyze quantitatively and collect cells in a flowing medium."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0003290 a rdfs:Class ;
  rdfs:label "mosquito membrane feeding assay" ;
  rdfs:comment "An assay that evaluates host-to-mosquito transmission of a parasite organism by feeding a specimen of host blood infected with the parasite organism to a collection of mosquitoes through a mosquito membrane feeding device and, after a given time, dissecting the mosquitoes and counting the number of parasite organisms within them."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002382 a rdfs:Class ;
  rdfs:label "grandfather clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male parent of a parent."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0003399 a rdfs:Class ;
  rdfs:label "Affymetrix Clariom S Assay, Human" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, to obtain a gene-level view of the human transcriptome. The assay design covers >20,000 well-annotated genes, providing researchers with the ability to perform gene-level expression profiling studies, to identify expression biomarkers , and to quickly assess changes in key genes and pathways."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0302892 a rdfs:Class ;
  rdfs:label "enzymatic ligation"@en ;
  rdfs:comment "An enzymatic ligation is a planned process in which molecules  are joined by covalent bonds through the action of an material entity with a ligase activity"@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0002376 a rdfs:Class ;
  rdfs:label "father clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male parent."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0002812 a rdfs:Class ;
  rdfs:label "protective apron" ;
  rdfs:comment "A personal protective clothing item which is an apron."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:CL_0000623 a rdfs:Class ;
  rdfs:label "natural killer cell" ;
  rdfs:comment "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." ;
  rdfs:subClassOf obo:CL_0000542 .

obo:OBI_0000701 a rdfs:Class ;
  rdfs:label "self-organizing map" ;
  rdfs:comment "A self-organizing map (SOM) is an artificial neural network with objective class discovery that uses a neighborhood function to preserve the topological properties of a dataset to produce low-dimensional (typically 2) discretized representation of the training data set. A set of artificial neurons learn to map points in an input space to coordinates in an output space. The input space can have different dimensions and topology from the output space, and the SOM will attempt to preserve these."@en ;
  rdfs:subClassOf obo:OBI_0200175 .

obo:PATO_0001547 a rdfs:Class ;
  rdfs:label "quality of a gas" ;
  rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." ;
  rdfs:subClassOf obo:PATO_0002198 .

obo:OBI_0002687 a rdfs:Class ;
  rdfs:label "ligase detection reaction" ;
  rdfs:comment "A linear amplification that uses a thermostable ligase to amplify a piece of DNA. Because the enzyme retains activity after multiple thermal cycles, the ligations may be repeated to linearly increase product."@en ;
  rdfs:subClassOf obo:OBI_0001494 .

obo:UBERON_0000362 a rdfs:Class ;
  rdfs:label "renal medulla" ;
  rdfs:comment "The inner portion of the kidney consisting of the renal pyramids." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:OBI_0001451 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-6 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-6 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0000820 a rdfs:Class ;
  rdfs:label "activated partial thromboplastin time assay" ;
  rdfs:comment "An assay that evaluates blood coagulation by measuring the time required for the appearance of fibrin strands following the mixing blood or plasma with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of blood coaguation . It is used as a screening test and to monitor heparin therapy."@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:CLO_0000031 a rdfs:Class ;
  rdfs:label "cell line"@en ;
  rdfs:comment """A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).  
""" ;
  rdfs:subClassOf obo:OBI_0100060 .

obo:OBI_0001758 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects chemokine (C-C motif) ligand 4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001345 , obo:OBI_0600031 .

obo:CHEBI_16991 a rdfs:Class ;
  rdfs:label "deoxyribonucleic acid" ;
  rdfs:comment "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." ;
  rdfs:subClassOf obo:CHEBI_33696 .

obo:PR_000003707 a rdfs:Class ;
  rdfs:label "adenosine deaminase" ;
  rdfs:comment "A protein that is a translation product of the human ADA gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003559 a rdfs:Class ;
  rdfs:label "intratracheal administration" ;
  rdfs:comment "An administration of a substance into the trachea of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0003079 a rdfs:Class ;
  rdfs:label "temperature measurement datum" ;
  rdfs:comment "A scalar measurement datum that is the result of measuring temperature."@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:UBERON_0003688 a rdfs:Class ;
  rdfs:label "omentum" ;
  rdfs:comment "A fold of peritoneum originating at the stomach and supporting the viscera." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0200130 a rdfs:Class ;
  rdfs:label "node degree calculation"@en ;
  rdfs:comment "A node quality calculation in which an input data set describing object nodes and relationship edges between object nodes is used to enumerate the number of unique relationships of an individual object node."@en ;
  rdfs:subClassOf obo:OBI_0200129 .

obo:OBI_0002823 a rdfs:Class ;
  rdfs:label "pre-moistened swab stick" ;
  rdfs:comment "A specimen collection swab stick that is pre-moistened with liquid prior to sampling."@en ;
  rdfs:subClassOf obo:OBI_0002820 .

obo:OBI_0001650 a rdfs:Class ;
  rdfs:label "immunoblot assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An immunoblot assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001703 , obo:OBI_0001978 .

obo:OBI_0200071 a rdfs:Class ;
  rdfs:label "loess transformation"@en ;
  rdfs:comment "A loess transformation is a data transformation that takes as input a collection of real number pairs (x, y) and, after performing (one or more) loess fittings, utilizes the resulting curves to transform each (x, y) in the input into (x, y-f(x)) where f(x) is one of the fitted curves."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0600012 a rdfs:Class ;
  rdfs:label "environmental material collection process"@en ;
  rdfs:comment "environmental_material_collection is an acquisition where an object is taken from an environment and put into a storage container. Roles include, environment, thing collected, container, acquirer."@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:CHEBI_60343 a rdfs:Class ;
  rdfs:label "1-methyl-7-nitroisatoic anhydride" ;
  rdfs:comment "A 3,1-benzoxazin-1,4-dione having an <em>N</em>-methyl substituent and a nitro group at the 7-position." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:UBERON_0007610 a rdfs:Class ;
  rdfs:label "tibial artery" ;
  rdfs:comment "The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot." ;
  rdfs:subClassOf obo:UBERON_0001637 .

obo:OBI_0002418 a rdfs:Class ;
  rdfs:label "exposure to diesel exhaust history" ;
  rdfs:comment "An exposure to environmental and workplace carcinogens history where the carcinogen is diesel exhaust."@en ;
  rdfs:subClassOf obo:OBI_0002415 .

obo:OBI_0002704 a rdfs:Class ;
  rdfs:label "insecticide resistance by detecting mixed-function oxidase assay" ;
  rdfs:comment "An insecticide resistance by detecting enzyme activity assay that measures whether mixed-function oxidase activity present."@en ;
  rdfs:subClassOf obo:OBI_0002697 .

obo:OBI_0000116 a rdfs:Class ;
  rdfs:label "worker role"@en ;
  rdfs:comment "a personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline"@en ;
  rdfs:subClassOf obo:OBI_0000202 .

obo:OBI_0200074 a rdfs:Class ;
  rdfs:label "submatrix extraction"@en ;
  rdfs:comment "A submatrix extraction is a projection whose input is a matrix and whose output is a matrix obtained by selecting certain rows and columns from the input. (Note that, if one represents the input matrix as a vector obtained by concatenating its rows, then extracting a submatrix is equivalent to projecting this vector into that composed by the entries belonging to the rows and columns of interest from the input matrix.)"@en ;
  rdfs:subClassOf obo:OBI_0200050 .

obo:CHEBI_17234 a rdfs:Class ;
  rdfs:label "glucose" ;
  rdfs:comment "An aldohexose used as a source of energy and metabolic intermediate." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003016 a rdfs:Class ;
  rdfs:label "myelocyte assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of myelocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:NCBITaxon_33213 a rdfs:Class ;
  rdfs:label "Bilateria" ;
  rdfs:subClassOf obo:NCBITaxon_33208 .

obo:OBI_0003474 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from other challenge resulting from the adoptive transfer of epitope specific T cells" ;
  rdfs:comment "An in vivo assay measuring a T cell epitope specific protection from other challenge after adoptive transfer of epitope specific T cells."@en ;
  rdfs:subClassOf obo:OBI_0001184 , obo:OBI_0002637 .

obo:OBI_0002195 a rdfs:Class ;
  rdfs:label "microtome blade" ;
  rdfs:comment "A device that is the part of a microtome used to slice specimens to a desired thickness."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003634 a rdfs:Class ;
  rdfs:label "antibody purification of H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003627 .

obo:OBI_0200178 a rdfs:Class ;
  rdfs:label "class discovery objective"@en ;
  rdfs:comment "A class discovery objective (sometimes called unsupervised classification) is a data transformation objective where the aim is to organize input data  (typically vectors of attributes) into classes, where the number of classes and their specifications are not known a priori. Depending on usage, the class assignment can be definite or probabilistic."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:GO_0015925 a rdfs:Class ;
  rdfs:label "galactosidase activity" ;
  rdfs:comment "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0003529 a rdfs:Class ;
  rdfs:label "spontaneous speech assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to articulate spoken words."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0400064 a rdfs:Class ;
  rdfs:label "laser" ;
  rdfs:comment "A laser (acronym for light amplification by the stimulated emission of radiation) is a light source that emits photons of the same characteristics in a coherent beam. A laser uses a solid, liquid or gaseous lasing medium, that contains molecules, of which some atoms have electrons that emit photons of the same frequency when falling back to their normal orbital after excitation (pumping) by external means A laser is the most common way to irradiate a cell in a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400065 .

obo:OBI_0002795 a rdfs:Class ;
  rdfs:label "disposable patient gown" ;
  rdfs:comment "A patient gown intended for a single period of continuous use and then disposed of."@en ;
  rdfs:subClassOf obo:OBI_0002792 .

obo:OBI_0302745 a rdfs:Class ;
  rdfs:label "obsolete_adipose tissue" ;
  rdfs:comment "adipose tissue is a tissue which main constituents are adipocytes. adipose tissue can be classified base on its location (site) but also based on adipocyte subtypes (brown or white) which reflect functional differences and is only found in animals, Vertebrates or invertebrates."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001992 a rdfs:Class ;
  rdfs:label "assay measuring the half maximal inhibitory concentration [IC50] of a MHC:ligand complex" ;
  rdfs:comment "A MHC binding constant determination assay measuring half maximal inhibitory concentration (IC50)."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003145 .

obo:OBI_0001989 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring equilibrium dissociation constant [KD] to determine competitive binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures equilibrium dissociation constant (KD) to detect the loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001988 .

obo:OBI_0002930 a rdfs:Class ;
  rdfs:label "light trap" ;
  rdfs:comment "An arthropod trap that uses light as an attractant."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0000712 a rdfs:Class ;
  rdfs:label "pathogen challenge" ;
  rdfs:comment "The administration of a live pathogenic organism to a host."@en ;
  rdfs:subClassOf obo:OBI_0003456 .

obo:IAO_8000015 a rdfs:Class ;
  rdfs:label "template generated ontology module"@en ;
  rdfs:comment "An ontology module that is automatically generated from a template specification and fillers for slots in that template."@en ;
  rdfs:seeAlso <http://robot.obolibrary.org/template> , <https://github.com/dosumis/dead_simple_owl_design_patterns/> , <https://doi.org/10.1186/s13326-017-0126-0> ;
  rdfs:subClassOf obo:IAO_8000014 .

obo:OBI_0003042 a rdfs:Class ;
  rdfs:label "optimal-IT rapid diagnostic test" ;
  rdfs:comment "A parasite detection assay that is rapid, sensitive, and able to differentiate between P. falciparum and other malaria parasites."@en ;
  rdfs:subClassOf obo:OBI_0003038 , obo:OBI_0003040 .

obo:OBI_0001698 a rdfs:Class ;
  rdfs:label "assay measuring B cell epitope specific in vivo activity" ;
  rdfs:comment "A B cell epitope dependent biological activity determination assay that uses an in vivo intervention experiment."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001706 .

obo:OBI_0000101 a rdfs:Class ;
  rdfs:label "measured expression level"@en ;
  rdfs:comment "A measurement datum that is the outcome of the quantification of an assay for the activity of a gene, or the number of RNA transcripts."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0001133 a rdfs:Class ;
  rdfs:label "denaturing high-performance liquid chromatography instrument" ;
  rdfs:comment "A high performance liquid chromatography instrument that employs temperature-dependent separation of DNA containing mismatched base pairs from PCR-amplified DNA fragments for chromatographic mutation analysis."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0000808 a rdfs:Class ;
  rdfs:label "spectrolyse heparin antifactor-Xa assay" ;
  rdfs:comment "An assay that quantitatively measures heparin in human plasma using Factor Xa and Antithrombin III in excess, where the rate of Factor Xa inhibition is directly proportional to the heparin concentration. The residual Factor Xa activity, measured with a Factor Xa-specific chromogenic substrate, is inversely proportional to the heparin concentration."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_1110193 a rdfs:Class ;
  rdfs:label "epitope specific IL-17 release by T cells"@en ;
  rdfs:comment "A biological process where T cells produce IL-17 resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032620 , obo:OBI_0001193 .

obo:OBI_0000667 a rdfs:Class ;
  rdfs:label "obsolete MHC multimer staining assay" ;
  rdfs:comment "An MHC multimer assay is an assay that detects T cells capable of binding the MHC:ligand complexes present in the multimer. The multimer is fluorescently labelled. The T cells bound to multimers are counted in a flow cytometer"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0001682 a rdfs:Class ;
  rdfs:label "bacterial one-hybrid assay" ;
  rdfs:comment "An assay that identifies the sequence-specific target site of a DNA-binding domain. In this system, a given transcription factor (TF) is expressed as a fusion to a subunit of RNA polymerase. In parallel, a library of randomized oligonucleotides representing potential TF target sequences, is cloned into a separate vector containing the selectable genes HIS3 and URA3. If the DNA-binding domain (bait) binds a potential DNA target site (prey) in vivo, it will recruit RNA polymerase to the promoter and activate transcription of the reporter genes in that clone. The two reporter genes, HIS3 and URA3, allow for positive and negative selections, respectively. At the end of the process, positive clones are sequenced and examined with motif-finding tools in order to resolve the favoured DNA target sequence"@en ;
  rdfs:subClassOf obo:OBI_0001681 .

obo:IAO_0000408 a rdfs:Class ;
  rdfs:label "length measurement datum"@en ;
  rdfs:comment "A scalar measurement datum that is the result of measurement of length quality"@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0003002 a rdfs:Class ;
  rdfs:label "arthropod resting in human house specimen collection by aspiration" ;
  rdfs:comment "An arthropod specimen collection by aspiration that catches specimens resting inside a human house."@en ;
  rdfs:subClassOf obo:OBI_0002912 .

obo:OBI_0000857 a rdfs:Class ;
  rdfs:label "complementary nucleotide probe role" ;
  rdfs:comment "A role played by a nucleic acid molecule that is used in a planned process for its ability to bind a nucleic acid molecules with complementary nucleotide sequence"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003346 a rdfs:Class ;
  rdfs:label "follow-up high resolution T1 weighted magnetic resonance image data set" ;
  rdfs:comment "A T1w image data set collected at a later time than the evaluant's first scan."@en ;
  rdfs:subClassOf obo:OBI_0003343 .

obo:GO_0032624 a rdfs:Class ;
  rdfs:label "interleukin-20 production" ;
  rdfs:comment "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000010 a rdfs:Class ;
  rdfs:label "fluorescent reporter intensity"@en ;
  rdfs:comment "A measurement datum that represents the output of a scanner measuring the intensity value for each fluorescent reporter."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0302908 a rdfs:Class ;
  rdfs:label "document editing"@en ;
  rdfs:comment "is a planned process with specified input original document and specified output edited document"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:GO_0097390 a rdfs:Class ;
  rdfs:label "chemokine (C-X-C motif) ligand 12 production" ;
  rdfs:comment "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:PR_000027247 a rdfs:Class ;
  rdfs:label "cytosolic creatine kinase complex, MB-type" ;
  rdfs:comment "A cytosolic creatine kinase complex that is a heterodimer of a B-type subunit and an M-type subunit." ;
  rdfs:subClassOf obo:GO_0032991 .

obo:OBI_0003345 a rdfs:Class ;
  rdfs:label "baseline high resolution T1 weighted magnetic resonance image data set" ;
  rdfs:comment "A T1w image data set collected at an evaluant's first visit in a study."@en ;
  rdfs:subClassOf obo:OBI_0003343 .

obo:OBI_2100303 a rdfs:Class ;
  rdfs:label "ABG/electrolytes arterial blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a ABG/electrolytes order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_1110128 a rdfs:Class ;
  rdfs:label "immune epitope assay" ;
  rdfs:comment "An assay that detects the binding of an epitope to an adaptive immune receptor, or an immune process resulting from such a binding event, or characterizes the structrue of the complex resulting from such a binding event."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0200063 a rdfs:Class ;
  rdfs:label "characteristic path length calculation"@en ;
  rdfs:comment "Quantifying subgraph navigability based on shortest-path length averaged over all pairs of subgraph vertices"@en ;
  rdfs:subClassOf obo:OBI_0200085 .

obo:OBI_1110085 a rdfs:Class ;
  rdfs:label "antigen presentation function"@en ;
  rdfs:comment "a function inhering in a cell  that expresses MHC molecules which is realized in the process of antigen processing and presentation of antigen derived parts by MHC molecules on the cell surface."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0000473 a rdfs:Class ;
  rdfs:label "Bruker NMR Case sample changer" ;
  rdfs:comment "The NMR Case is an economical NMR sample changer for laboratories with modest automation needs. It expands the maximum number of samples your spectrometer can process during unattended operation to 24. The NMR Case consists of multiple components. The NMR Case exchange module installed atop your cryostat. The two front legs are adjustable, making the NMR Case compatible with many different cryostats."@en ;
  rdfs:subClassOf obo:OBI_0000464 .

obo:OBI_0002022 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 1000" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation, with a single flow cell and a throughput of up to 35 Gb per day. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology."@en ;
  rdfs:subClassOf obo:OBI_0003683 .

obo:OBI_0002957 a rdfs:Class ;
  rdfs:label "reverse phase protein array profiling assay" ;
  rdfs:comment "A type of protein state assay where tissue or cell samples are lysed and then spotted onto a slide which is probed with antibodies specific to proteins with and without post-translational modifications."@en ;
  rdfs:subClassOf obo:OBI_0002953 .

obo:OBI_0000724 a rdfs:Class ;
  rdfs:label "Solexa sequencing assay" ;
  rdfs:comment "A DNA sequencing by synthesis assay that identifies sequence information using DNA polymerase and reversible terminator, requiring immobilization of genomic DNA fragments onto a surface and a specific clonal amplification step known as bridge PCR. Reliance on a reversible terminator allows cycles of DNA chain extension by DNA polymerase and imaging without the need of electrophoretic separation of newly synthesized DNA fragment as with Sanger sequencing."@en ;
  rdfs:subClassOf obo:OBI_0000734 .

obo:OBI_0000749 a rdfs:Class ;
  rdfs:label "CART"@en ;
  rdfs:comment "A CART (classification and regression trees) is a data transformation method for producing a classification or regression model with a tree-based structure."@en ;
  rdfs:subClassOf obo:OBI_0000707 .

obo:OBI_0003666 a rdfs:Class ;
  rdfs:label "lavage fluid specimen" ;
  rdfs:comment "A specimen obtained through a lavage process which includes fluid in addition to cells and/or cellular secretions."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001401 a rdfs:Class ;
  rdfs:label "protocol optimization design" ;
  rdfs:comment "A study design where different protocols or protocol parameters are compared aims to find an optimized protocol"@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003561 a rdfs:Class ;
  rdfs:label "intra-arterial administration" ;
  rdfs:comment "An administration of a substance into the artery of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0001967 a rdfs:Class ;
  rdfs:label "multiplexing sequence identifier"@en ;
  rdfs:comment "A multiplexing sequence identifier is a nucleic acid sequence which is used in a ligation step of library preparation process to allow pooling of samples while maintaining ability to identify individual source material and creation of a multiplexed library"@en ;
  rdfs:subClassOf obo:CHEBI_16991 .

obo:OBI_0400022 a rdfs:Class ;
  rdfs:label "Cyan" ;
  rdfs:comment "A Cyan is a flow_cytometer_analyser manufactured by Dako Cytomation. It features include digital electronics, three lasers: 488 nm, 635 nm, and 405 nm, and filters and collectors for nine fluorescent parameters and two scatter parameters. The Cyan can be used for measuring the properties of individual cells."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0002413 a rdfs:Class ;
  rdfs:label "perimenopausal status" ;
  rdfs:comment "A menopausal status indicating that it has been 6-12 months since last menstrual period."@en ;
  rdfs:subClassOf obo:OBI_0002410 .

obo:OBI_0002113 a rdfs:Class ;
  rdfs:label "bromouridine labeling and sequencing assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay used to identify spans of nascent transcription in the genome through isolation of recent bromouridine (Bru) labelled RNAs."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0003469 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific survival after tumor challenge" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from tumor challenge using survival."@en ;
  rdfs:subClassOf obo:OBI_0003459 , obo:OBI_0003466 .

obo:OBI_0002473 a rdfs:Class ;
  rdfs:label "material amplification role"@en ;
  rdfs:comment "A worker role played by the person who runs the enzymatic amplifying process."@en ;
  rdfs:subClassOf obo:OBI_0000116 .

obo:OBI_0003719 a rdfs:Class ;
  rdfs:label "respiratory assay" ;
  rdfs:comment "A vital sign assay that measures the quality of respiration / respiratory system of an organism"@en ;
  rdfs:subClassOf obo:OBI_0003715 .

obo:PATO_0000146 a rdfs:Class ;
  rdfs:label "temperature" ;
  rdfs:comment "A physical quality of the thermal energy of a system." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0003136 a rdfs:Class ;
  rdfs:label "transgenic mutagenesis" ;
  rdfs:comment "A form of random mutagenesis that produces a mutation by introducing a construct into the genome of an organism in a random or semi-random fashion."@en ;
  rdfs:subClassOf obo:OBI_0002620 .

obo:OBI_0003361 a rdfs:Class ;
  rdfs:label "lesion mask" ;
  rdfs:comment "An image data set where voxel intensity values greater than zero encode the location of some brain lesion and voxels outside the lesion have an intensity value of zero."@en ;
  rdfs:subClassOf obo:OBI_0003360 .

obo:OBI_0000518 a rdfs:Class ;
  rdfs:label "trap column" ;
  rdfs:comment "A trap column is a chromatography column which is used prior to a, e.g. mass spectrometry, separation to clean up or concentrate controlled amounts of samples prior to elution to a detector."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0002964 a rdfs:Class ;
  rdfs:label "KiNativ assay" ;
  rdfs:comment "A type of proprietary in situ kinase inhibitor assay that employs biotinylated acyl phosphates of ATP and ADP."@en ;
  rdfs:subClassOf obo:OBI_0002962 .

obo:GO_0071706 a rdfs:Class ;
  rdfs:label "tumor necrosis factor superfamily cytokine production" ;
  rdfs:comment "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0002912 a rdfs:Class ;
  rdfs:label "arthropod specimen collection by aspiration" ;
  rdfs:comment "A live arthropod specimen collection process that involves the use of an aspirator, a device which draws an arthropod by suction into a container."@en ;
  rdfs:subClassOf obo:OBI_0002904 .

obo:OBI_2000005 a rdfs:Class ;
  rdfs:label "respiratory system specimen" ;
  rdfs:comment "A specimen that is derived from some respiratory system"@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_2100082 a rdfs:Class ;
  rdfs:label "liver evaluation venous blood albumin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of albumin in venous blood as part of a liver evaluation order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100022 .

obo:OBI_2100314 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:CHEBI_29237 a rdfs:Class ;
  rdfs:label "deuterium atom" ;
  rdfs:comment "The stable isotope of hydrogen with relative atomic mass 2.014102 and a natural abundance of 0.0115 atom percent (from Greek δευτερον, second)." ;
  rdfs:subClassOf obo:COB_0000011 .

obo:OBI_0002784 a rdfs:Class ;
  rdfs:label "anterior nasal swab specimen" ;
  rdfs:comment "A specimen that is derived from the anterior nasal wall"@en ;
  rdfs:subClassOf obo:OBI_0000917 .

obo:OBI_2100001 a rdfs:Class ;
  rdfs:label "carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003161 a rdfs:Class ;
  rdfs:label "metamyelocyte count assay" ;
  rdfs:comment "A metamyelocyte assay that measures the number of metamyelocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003017 .

obo:PR_000018263 a rdfs:Class ;
  rdfs:label "amino acid chain" ;
  rdfs:comment "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0000433 a rdfs:Class ;
  rdfs:label "DNA sequence feature detection assay" ;
  rdfs:comment "An assay with the objective to determine a sequence feature of DNA"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000794 a rdfs:Class ;
  rdfs:label "obsolete transcription factor binding site" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:GO_0001788 a rdfs:Class ;
  rdfs:label "antibody-dependent cellular cytotoxicity" ;
  rdfs:comment "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001086 a rdfs:Class ;
  rdfs:label "radiation measurement device" ;
  rdfs:comment "A device that consists of a radiosensitive detector and a means of recording the effects of radiation on the detector."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0001671 a rdfs:Class ;
  rdfs:label "electrophoretic mobility shift assay" ;
  rdfs:comment "An assay that measures information about Protein-DNA or Protein-RNA interactions using gel electrophoresis and relying on the fact the molecular interactions will cause the heterodimer to be retarded on the gel when compared to controls corresponding to protein extract alone and protein extract + neutral nucleic acid."@en ;
  rdfs:subClassOf obo:OBI_0001146 .

obo:OBI_0000706 a rdfs:Class ;
  rdfs:label "SOLiD sequencing assay" ;
  rdfs:comment "A DNA sequencing by ligation assay that identifies sequence information using primers to hybridize to the P1 adapter sequence within the library template, fluorescently labeled di-base probes to compete for ligation to the sequencing primer, multiple cycles of ligation, detection and cleavage to determine the eventual read length, following a series of ligation cycles, the extension product is removed and the template is reset with a primer complementary to the n-1 position for a second round of ligation cycles."@en ;
  rdfs:subClassOf obo:OBI_0000723 .

obo:OBI_0001230 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-5 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-5 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002517 a rdfs:Class ;
  rdfs:label "hair specimen" ;
  rdfs:comment "A specimen that is derived from hair."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:GO_0004021 a rdfs:Class ;
  rdfs:label "L-alanine:2-oxoglutarate transaminase activity" ;
  rdfs:comment "Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_0001016 a rdfs:Class ;
  rdfs:label "DNASE 1 structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution deoxyribonucleic acid structure mapping assay which uses DNAse 1 as reagent and enzymatic probe to generate data and information at nucleotide resolution scale contributing to the determination of nucleic acid secondary structure"@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:GO_0003016 a rdfs:Class ;
  rdfs:label "respiratory system process" ;
  rdfs:comment "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003599 a rdfs:Class ;
  rdfs:label "single cell T cell receptor repertoire sequencing assay" ;
  rdfs:comment "A T cell receptor repertoire sequencing assay that determines the sequence of DNA or RNA molecules that encode the repertoire of T cell receptors that can be traced to a single cell of origin."@en ;
  rdfs:subClassOf obo:OBI_0002990 .

obo:OBI_2100128 a rdfs:Class ;
  rdfs:label "inpatient profile venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood as part of a inpatient profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:OBI_2100259 a rdfs:Class ;
  rdfs:label "intact venous blood PTH assay" ;
  rdfs:comment "An analyte assay that measures the abundance of PTH in venous blood as part of a intact order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100034 .

obo:OBI_0001552 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific tumor necrosis factor (ligand) superfamily member 11 production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects tumor necrosis factor (ligand) superfamily member 11 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001385 , obo:OBI_0001607 .

obo:OBI_2100371 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0001193 a rdfs:Class ;
  rdfs:label "epitope specific cytokine production by T cells" ;
  rdfs:comment "A process of cytokine production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000105 a rdfs:Class ;
  rdfs:label "transplantation"@en ;
  rdfs:comment "a protocol application to replace an organ or tissue of an organism"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:MRO_0001356 a rdfs:Class ;
  rdfs:label "MHC class II protein complex" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:UBERON_0001826 a rdfs:Class ;
  rdfs:label "nasal cavity mucosa" ;
  rdfs:comment "The mucous membrane that lines the nasal cavity[MP]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0002383 a rdfs:Class ;
  rdfs:label "nephew clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male child of a sibling."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_1110019 a rdfs:Class ;
  rdfs:label "pathogen release in laboratory accident"@en ;
  rdfs:comment "a process in which a an infectious agent maintained in a laboratory setting is not contained as planned, leading to potential exposure of human beings to the agent"@en ;
  rdfs:subClassOf obo:OBI_1110111 .

obo:OBI_0000750 a rdfs:Class ;
  rdfs:label "study design independent variable"@en ;
  rdfs:comment "a directive information entity that is part of a study design. Independent variables are entities whose values are selected to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled"@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:NCBITaxon_160 a rdfs:Class ;
  rdfs:label "Treponema pallidum" ;
  rdfs:subClassOf obo:NCBITaxon_3379134 .

obo:OBI_0001605 a rdfs:Class ;
  rdfs:label "binding on rate measurement datum (kon)" ;
  rdfs:comment "A rate measurement datum of how quickly bound complexes form"@en ;
  rdfs:subClassOf obo:OBI_0001144 , obo:OBI_0001554 .

obo:OBI_0003015 a rdfs:Class ;
  rdfs:label "globulin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of globulin"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:UBERON_0000316 a rdfs:Class ;
  rdfs:label "cervical mucus" ;
  rdfs:comment "A substance produced by the cervix and endocervical glands[BTO]. Thick acidic mucus that blocks the cervical os after mestruation[WP]. This 'infertile' mucus blocks spermatozoa from entering the uterus." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0000372 a rdfs:Class ;
  rdfs:label "material separation function"@en ;
  rdfs:comment "A material separation function is a function that increases the resolution between two or more material entities. The  to distinction between the entities is usually based on some associated physical quality."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:GO_1903339 a rdfs:Class ;
  rdfs:label "negative regulation of cell wall organization or biogenesis" ;
  rdfs:comment "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall organization or biogenesis." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003550 a rdfs:Class ;
  rdfs:label "odor baited CDC light trap" ;
  rdfs:comment "A CDC light trap that uses odorous gas from a human being as an attractant, by pumping it from the room where the human being sleeps into the trap."@en ;
  rdfs:subClassOf obo:OBI_0002926 .

obo:OBI_0000059 a rdfs:Class ;
  rdfs:label "gamma counter" ;
  rdfs:comment "A processed material which measures gamma radiation"@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0002785 a rdfs:Class ;
  rdfs:label "aspiration specimen collection"@en ;
  rdfs:comment "Procedure using suction, usually with a thin needle and syringe, to remove bodily fluid or tissue."@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:OBI_0003831 a rdfs:Class ;
  rdfs:label "population count assay" ;
  rdfs:comment "An assay that measures the number of elements in a portion of a population"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002401 a rdfs:Class ;
  rdfs:label "hormonal birth control use history" ;
  rdfs:comment "An information content entity that indicates whether a woman has ever used oral contraceptives in order to block ovulation and prevent the occurrence of pregnancy."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_2100010 a rdfs:Class ;
  rdfs:label "chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001028 a rdfs:Class ;
  rdfs:label "feature extraction" ;
  rdfs:comment "A planed process with objective of obtaining quantified values from an image."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0002133 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring  epitope specific chemokine (C-C motif) ligand 20 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects chemokine (C-C motif) ligand 20 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0002134 , obo:OBI_0003115 .

obo:OBI_0003190 a rdfs:Class ;
  rdfs:label "erythrocyte assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of erythrocytes."@en ;
  rdfs:subClassOf obo:OBI_0003018 .

obo:OBI_1110152 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001445 .

obo:OBI_0002693 a rdfs:Class ;
  rdfs:label "restriction fragment length polymorphism assay" ;
  rdfs:comment "An assay that uses digestion of DNA with specific restriction enzymes followed by gel electropheresis to detect differences in the sizes of the generated fragments that are due to genetic differences (polymorphisms) in homologous sequences."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0002923 a rdfs:Class ;
  rdfs:label "barrier trap" ;
  rdfs:comment "An arthropod trap consisting of a static physical barrier designed to funnel arthropods in flight into a container."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0003171 a rdfs:Class ;
  rdfs:label "sodium(1+) concentration assay" ;
  rdfs:comment "A sodium(1+) assay that measures the concentration of sodium(1+) in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100002 .

obo:OBI_0000787 a rdfs:Class ;
  rdfs:label "human antithrombin-III in blood assay" ;
  rdfs:comment "An assay that measures the amount of antithrombin III in blood."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:PATO_0001300 a rdfs:Class ;
  rdfs:label "optical quality" ;
  rdfs:comment "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." ;
  rdfs:subClassOf obo:PATO_0070060 .

obo:OBI_0003150 a rdfs:Class ;
  rdfs:label "calcium cation concentration assay" ;
  rdfs:comment "A calcium cation assay that measures the concentration of calcium cations in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100024 .

obo:OBI_0001369 a rdfs:Class ;
  rdfs:label "wild type allele information"@en ;
  rdfs:comment "an allele information that is about the allele found most frequently in natural populations, or in standard laboratory stocks for a given organism."@en ;
  rdfs:subClassOf obo:OBI_0001352 .

obo:OBI_0003667 a rdfs:Class ;
  rdfs:label "oral lavage fluid" ;
  rdfs:comment "A specimen collected through oral cavity lavage that contains the reagents used to for the lavage process, organisms, cells, cellular secretions, and other biomaterials present in the oral cavity space."@en ;
  rdfs:subClassOf obo:OBI_0003666 .

obo:OBI_0003113 a rdfs:Class ;
  rdfs:label "proximity extension assay" ;
  rdfs:comment "An analyte assay that uses quantitative polymerase chain reaction (qPCR) technology to determine the concentration/presence of an analyte or analyte complex."@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0002692 .

obo:OBI_0000567 a rdfs:Class ;
  rdfs:label "Bruker UltraShield NMR magnet" ;
  rdfs:comment "An NMR magnet manufactured by Bruker that ensures field homogeneity without amplified effects from vibrations or thermal changes. This magnet technology uses active shielding and optimizes coil design."@en ;
  rdfs:subClassOf obo:OBI_0000597 .

obo:OBI_2100050 a rdfs:Class ;
  rdfs:label "macrophage count assay" ;
  rdfs:comment "A cytometry assay that measures the count of macrophages"@en ;
  rdfs:subClassOf obo:OBI_0003027 .

obo:OBI_0100051 a rdfs:Class ;
  rdfs:label "specimen"@en ;
  rdfs:comment "A material entity that is collected for potential use as an input upon which measurements or observations are performed."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000899 a rdfs:Class ;
  rdfs:label "organellar RNA extract" ;
  rdfs:comment "A RNA extract that is the output of an extraction process in which RNA molecules found in an organelle, e.g., mitochondrion, ER, or chloroplast, excluding the nucleus, are extracted."@en ;
  rdfs:subClassOf obo:OBI_0000880 .

obo:OBI_0001009 a rdfs:Class ;
  rdfs:label "obsolete_qualitative binding detection assay" ;
  rdfs:comment "A binding assay where the specified output determines if two or more material entities do or do not have the disposition to form a complex above a threshold level of significance. The threshold can be defined through detection limits of the instrument, the use of experimental controls that establish what is considered significant binding, or a predefined cutoff based on what binding is considered significant in a certain context."@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_2100105 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood segmented neutrophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of segmented neutrophils in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003022 , obo:OBI_0003040 .

obo:OBI_0003600 a rdfs:Class ;
  rdfs:label "hypertension grade" ;
  rdfs:comment "A categorical value specification that indicates the severity of hypertension."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0000491 a rdfs:Class ;
  rdfs:label "direct detection NMR probe" ;
  rdfs:comment "An NMR probe designed to allow the direct detection of acquisition nuclei."@en ;
  rdfs:subClassOf obo:OBI_0000516 .

obo:OBI_0000100 a rdfs:Class ;
  rdfs:label "obsolete_role of being first subject treated" ;
  rdfs:comment "First subject treated role is a study subject role borne by the subject realized in the application of the process specified in intervention study design with no previous study subject realizing the role prior in the study"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0200123 a rdfs:Class ;
  rdfs:label "skewness calculation"@en ;
  rdfs:comment "A skewness calculation is a descriptive statistics calculation defined as a parameter that describes how much a distribution (or a data set) varies from a bell-shaped curve.  See http://www.riskglossary.com/link/skewness.htm for details.  It is also known as the third central moment"@en ;
  rdfs:subClassOf obo:OBI_0200181 , obo:OBI_0200184 .

obo:OBI_0000186 a rdfs:Class ;
  rdfs:label "protocol optimization objective"@en ;
  rdfs:comment "Protocol_optimization is a protocol_testing_objective role describing a study designed to identify the best protocol.  This may be carried out by comparing different protocols or by modifying the parameters used within a single protocol."@en ;
  rdfs:subClassOf obo:OBI_0000096 .

obo:OBI_0002990 a rdfs:Class ;
  rdfs:label "T cell receptor repertoire sequencing assay" ;
  rdfs:comment "A sequencing assay that determines the sequences of DNA or RNA molecules that encode the repertoire of T cell receptors within an input sample."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_0002628 a rdfs:Class ;
  rdfs:label "RNAi knockdown assay" ;
  rdfs:comment "A gene knockdown assay in which RNAi gene knockdown is used to disrupt gene transcripts."@en ;
  rdfs:subClassOf obo:OBI_0001672 .

obo:OBI_0200104 a rdfs:Class ;
  rdfs:label "principal component regression"@en ;
  rdfs:comment "The Principal Component Regression method is a regression analysis method that combines the Principal Component Analysis (PCA)spectral decomposition with an Inverse Least Squares (ILS) regression method to create a quantitative model for complex samples. Unlike quantitation methods based directly on Beer's Law which attempt to calculate the absorbtivity coefficients for the constituents of interest from a direct regression of the constituent concentrations onto the spectroscopic responses, the PCR method regresses the concentrations on the PCA scores."@en ;
  rdfs:subClassOf obo:OBI_0200102 , obo:OBI_0200175 .

obo:OBI_0001836 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-16 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-16 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001280 .

obo:GO_0004457 a rdfs:Class ;
  rdfs:label "lactate dehydrogenase activity" ;
  rdfs:comment "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." ;
  rdfs:subClassOf obo:GO_0003824 .

obo:OBI_2100332 a rdfs:Class ;
  rdfs:label "manual differential bodily fluid mesothelial cell count assay" ;
  rdfs:comment "A cytometry assay that measures the count of mesothelial cells in bodily fluid as part of a manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002614 a rdfs:Class ;
  rdfs:label "birth cohort study design" ;
  rdfs:comment "A cohort study design for which the subjects are followed from the time of birth usually including information about gestation and follow up."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0003904 a rdfs:Class ;
  rdfs:label "count of multi-electrode plate electrodes detecting neuron burst assay" ;
  rdfs:comment "A multi-electrode array assay that measures the number of electrodes in a well where the burst rate is at least 0.5 bursts per minute."@en ;
  rdfs:subClassOf obo:OBI_0003901 .

obo:OBI_0000451 a rdfs:Class ;
  rdfs:label "normalized data set"@en ;
  rdfs:comment "A data set that is produced as the output of a normalization data transformation."@en ;
  rdfs:subClassOf obo:IAO_0000100 .

obo:CHEBI_35366 a rdfs:Class ;
  rdfs:label "fatty acid" ;
  rdfs:comment "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003372 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific lymphotactin production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects lymphotactin production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_2100213 a rdfs:Class ;
  rdfs:label "hepatic panel venous blood bilirubin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bilirubin in venous blood as part of a hepatic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100018 .

obo:OBI_0001881 a rdfs:Class ;
  rdfs:label "organization of Bioinformatics Resource Center contact person"@en ;
  rdfs:comment "An organization that is the affiliation of the person who is contact representative of a Bioinformatics Resource Center"@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_2100277 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0000555 a rdfs:Class ;
  rdfs:label "autosampler" ;
  rdfs:comment "An optional part of an NMR instrument used to hold samples prior to NMR analysis and that sequentially loads these samples into the analytical part of the NMR instrument. n   alt The autosampler is an automatic sample changer device."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0003005 a rdfs:Class ;
  rdfs:label "device for collection of resting adult arthropods" ;
  rdfs:comment "A device that is designed to provide a solid surface that is attractive to an arthropod as a place to rest during a period of inactivity."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000990 a rdfs:Class ;
  rdfs:label "electron microscope" ;
  rdfs:comment "A microscope that produces an image of an object by targeting it with an electron beam"@en ;
  rdfs:subClassOf obo:OBI_0400169 .

obo:CHEBI_28864 a rdfs:Class ;
  rdfs:label "tobramycin" ;
  rdfs:comment "A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:COB_0000013 a rdfs:Class ;
  rdfs:label "molecule"@en ;
  rdfs:comment "A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000060 a rdfs:Class ;
  rdfs:label "trial monitor role"@en ;
  rdfs:comment "a responsible party involved in planning, overseeing the conduct of a study or study component, and interpreting data from a study"@en ;
  rdfs:subClassOf obo:OBI_0000102 .

obo:UBERON_0003128 a rdfs:Class ;
  rdfs:label "cranium" ;
  rdfs:comment "Upper portion of the skull that excludes the mandible (when present in the organism)." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001664 a rdfs:Class ;
  rdfs:label "intracellular material detection assay measuring epitope specific granulysin release by T cells" ;
  rdfs:comment "A flow cytometry assay that detects epitope specific granulysin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001810 .

obo:OBI_0500026 a rdfs:Class ;
  rdfs:label "eligibility criterion"@en ;
  rdfs:comment """an eligibility criterion (rule) is_a selection criterion which 
defines and states the requirements (positive or negative) for an entity to be considered as suitable for a given task or participation in a process."""@en ;
  rdfs:subClassOf obo:OBI_0001755 .

obo:OBI_0200156 a rdfs:Class ;
  rdfs:label "data partitioning"@en ;
  rdfs:comment "Data partitioning is a data transformation with the objective of partitioning or separating input data into output subsets."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0002485 a rdfs:Class ;
  rdfs:label "transcript analysis by single-end sequencing assay" ;
  rdfs:comment "A sequencing assay that incorporates single-end reads and sequencing technology to determine transcripts, gene structures, and gene expressions."@en ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBI_2100140 a rdfs:Class ;
  rdfs:label "urine osmolality assay" ;
  rdfs:comment "An assay that measures osmolality in urine"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100039 .

obo:OBI_0002997 a rdfs:Class ;
  rdfs:label "arthropod attractor role" ;
  rdfs:comment "A role of a material entity realized in drawing an arthropod in the direction of the material."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000381 a rdfs:Class ;
  rdfs:label "liquid filter function"@en ;
  rdfs:comment "A liquid filter function is a filter function which prevents the flow of solid objects, defined by specific qualities, in a liquid-solid mixture"@en ;
  rdfs:subClassOf obo:OBI_0000378 .

obo:OBI_0003037 a rdfs:Class ;
  rdfs:label "malaria rapid diagnosis assay" ;
  rdfs:comment "An assay that is quick and easy in the diagnosis of malaria by detecting evidence of malaria parasites (antigens) in human blood."@en ;
  rdfs:subClassOf obo:OBI_0003038 , obo:OBI_0003040 .

obo:OBI_0001702 a rdfs:Class ;
  rdfs:label "immunoglobulin binding to epitope" ;
  rdfs:comment "a process of an immunoglobulin complex binding to a material entity at the immunoglobulin complementarity determining region (CDR)."@en ;
  rdfs:subClassOf obo:OBI_0001588 , obo:OBI_1110014 .

obo:OBI_0001557 a rdfs:Class ;
  rdfs:label "material storage service" ;
  rdfs:comment "A storage service in which a service consumer provides some material as input which a service provider stores and returns as output."@en ;
  rdfs:subClassOf obo:OBI_0001515 , obo:OBI_0001528 .

obo:OBI_0001888 a rdfs:Class ;
  rdfs:label "sequencing facility contact person"@en ;
  rdfs:comment "A person who is the contact representative at the sequencing facility"@en ;
  rdfs:subClassOf obo:NCBITaxon_9606 .

obo:OBI_0002386 a rdfs:Class ;
  rdfs:label "diagnosis of hepatitis B" ;
  rdfs:comment "A diagnosis of infectious disease caused by the hepatitis B virus."@en ;
  rdfs:subClassOf obo:OBI_0002385 .

obo:OBI_0400104 a rdfs:Class ;
  rdfs:label "array scanner" ;
  rdfs:comment "An processed material which acquires images of fluorescence (induced with lasers) from labeled molecules on the surface of the microarray chip"@en ;
  rdfs:subClassOf obo:OBI_0000398 .

obo:OBI_0002204 a rdfs:Class ;
  rdfs:label "pNX" ;
  rdfs:comment "A cannot be assessed determination of pathologic staging of lymph nodes."@en ;
  rdfs:subClassOf obo:OBI_0002200 .

obo:OBI_0003208 a rdfs:Class ;
  rdfs:label "luteinizing hormone assay" ;
  rdfs:comment "An analyte assay that measures the abundance of luteinizing hormone"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:CHEBI_33697 a rdfs:Class ;
  rdfs:label "ribonucleic acid" ;
  rdfs:comment "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." ;
  rdfs:subClassOf obo:CHEBI_33696 .

obo:OBI_0001765 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific chemokine (C-C motif) ligand 4 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects chemokine (C-C motif) ligand 4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001345 .

obo:OBI_0002439 a rdfs:Class ;
  rdfs:label "chromosome conformation capture assay" ;
  rdfs:comment "A nuclear ligation assay that detects chromosomal interactions between any two genomic loci. Chromatin segments are cross-linked, cut by restriction enzymes, ligated, and finally analyzed by PCR."@en ;
  rdfs:subClassOf obo:OBI_0002438 .

obo:OBI_0000278 a rdfs:Class ;
  rdfs:label "disease stage"@en ;
  rdfs:comment "a part of an occurrence of a disease process which is associated with position in the normal progression of the disease"@en ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001326 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-4 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-4 production by T cells"@en ;
  rdfs:subClassOf obo:OBI_0001450 , obo:OBI_0003115 .

obo:OBI_0000851 a rdfs:Class ;
  rdfs:label "obsolete_diethyl pyrocarbonate" ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000445 a rdfs:Class ;
  rdfs:label "mass measurement assay" ;
  rdfs:comment "An assay that determines the mass of an evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0050896 a rdfs:Class ;
  rdfs:label "response to stimulus" ;
  rdfs:comment "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0000615 a rdfs:Class ;
  rdfs:label "protein expression profiling assay" ;
  rdfs:comment "An assay that determines protein expression and translation activity using protein extracts collected from a material entity."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:GO_0043005 a rdfs:Class ;
  rdfs:label "neuron projection" ;
  rdfs:comment "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." ;
  rdfs:subClassOf obo:GO_0005575 .

obo:OBI_0003757 a rdfs:Class ;
  rdfs:label "cell viability assay based on detection of resorufin" ;
  rdfs:comment "A cell viability assay using the NAD(P)H-aided conversion of resazurin to resorufin by metabolically active cells."@en ;
  rdfs:subClassOf obo:OBI_0003583 .

obo:OBI_0001207 a rdfs:Class ;
  rdfs:label "epitope specific macrophage inflammatory protein-1 alpha production by T cells" ;
  rdfs:comment "A process of macrophage inflammatory protein-1 alpha production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0071608 , obo:OBI_0001193 .

obo:OBI_0500015 a rdfs:Class ;
  rdfs:label "2x2 factorial design" ;
  rdfs:comment "a factorial design which has 2 experimental factors (aka independent variables) and 2 factor levels per experimental factors"@en ;
  rdfs:subClassOf obo:OBI_0500014 .

obo:OBI_0001546 a rdfs:Class ;
  rdfs:label "comparative phenotypic assessment" ;
  rdfs:comment "Interpreting data from assays that evaluate the qualities or dispositions inhering in an organism or organism part and comparing it to data from other organisms to make a conclusion about a phenotypic difference"@en ;
  rdfs:subClassOf obo:OBI_0000338 , obo:OBI_0001834 .

obo:OBI_2100367 a rdfs:Class ;
  rdfs:label "venous blood WBC count assay" ;
  rdfs:comment "A cytometry assay that measures the count of WBCs in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003040 .

obo:OBI_2100325 a rdfs:Class ;
  rdfs:label "non-cardiac venous blood c-reactive protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of c-reactive protein in venous blood as part of a non-cardiac order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100047 .

obo:UBERON_0001087 a rdfs:Class ;
  rdfs:label "pleural fluid" ;
  rdfs:comment "Transudate contained in the pleural cavity." ;
  rdfs:subClassOf obo:UBERON_0006314 .

obo:OBI_0001739 a rdfs:Class ;
  rdfs:label "surface plasmon resonance assay measuring the off rate [koff] of a B cell epitope:antibody complex" ;
  rdfs:comment "A surface plasmon resonance binding assay that measures the off rate [koff] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000923 , obo:OBI_0001723 .

obo:OBI_0002592 a rdfs:Class ;
  rdfs:label "genetic interaction identification design" ;
  rdfs:comment "A molecular interaction identification design that investigates a phenotype that is the result of two or more genetic perturbations, and is not explained by the individual genetic perturbations alone."@en ;
  rdfs:subClassOf obo:OBI_0002590 .

obo:GO_0036392 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 20 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0000078 a rdfs:Class ;
  rdfs:label "eMedical record"@en ;
  rdfs:comment "An eMedical record is a digital document derived from a computer system used primarily for patient care in a clinical setting.  Not required to be compliant with requirements of 21 CFR Part 11."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0002625 a rdfs:Class ;
  rdfs:label "gene knockdown" ;
  rdfs:comment "A genetic transformation which reduces the expression of a specific gene or genes in an organism."@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_0003110 a rdfs:Class ;
  rdfs:label "gas chromatography mass spectrometry assay" ;
  rdfs:comment "A mass spectrometry assay combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determination of compounds."@en ;
  rdfs:subClassOf obo:OBI_0000470 .

obo:OBI_0002419 a rdfs:Class ;
  rdfs:label "exposure to chromium history" ;
  rdfs:comment "An exposure to environmental and workplace carcinogens history where the carcinogen is chromium."@en ;
  rdfs:subClassOf obo:OBI_0002415 .

obo:OBI_0003340 a rdfs:Class ;
  rdfs:label "proton density magnetic resonance image data set" ;
  rdfs:comment "An magnetic resonance image data set in which the contrast emphasizes density of protons, supressing T1 and T2 effects"@en ;
  rdfs:subClassOf obo:OBI_0003334 .

obo:MRO_0001533 a rdfs:Class ;
  rdfs:label "HLA protein complex with A24 serotype" ;
  rdfs:subClassOf obo:GO_0042611 .

obo:OBI_0400054 a rdfs:Class ;
  rdfs:label "Amnis ImageStream" ;
  rdfs:comment "The ImageStream is a multispectral_imaging_flow_cytometer manufactured by Amnis. Its has digital electronics, a single standard 488 nm solid state laser. In addition an optional 658 nm and your choice of either a 405 nm or 375 nm solid state laser can be added. Information is collected using cameras. The ImageStream system CCD camera produces six images of each cell, including darkfield, brightfield, and up to four fluorescent colors. Each image is used to calculate over 40 features, so a six-image assay results in ~250 morphometric and photometric features per cell. The ImageStream is a flow cytometer that takes pictures of the cells in flow. It has both components, an Image cytometer and a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400146 .

obo:OBI_0003688 a rdfs:Class ;
  rdfs:label "sand bath" ;
  rdfs:comment "A temperature control bath in which sand acts as contact medium for the temperature transfer (from heating or cooling elements to the sample)."@en ;
  rdfs:subClassOf obo:OBI_0400120 .

obo:OBI_0001467 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific disease exacerbation" ;
  rdfs:comment "An efficacy of T cell epitope intervention experiment that uses a disease exacerbation in vivo intervention experiment."@en ;
  rdfs:subClassOf obo:OBI_0001188 , obo:OBI_0001484 .

obo:OBI_0003820 a rdfs:Class ;
  rdfs:label "cell migration assay" ;
  rdfs:comment "A distance measurement assay in which the migration of cells in culture is monitored by measuring the distance between the start position and the cell's location when observed."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0003816 .

obo:OBI_0000456 a rdfs:Class ;
  rdfs:label "material transformation objective"@en ;
  rdfs:comment "an objective specifiction that creates an specific output object from input materials."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_2100206 a rdfs:Class ;
  rdfs:label "venous blood tobramycin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of tobramycin in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100045 .

obo:OBI_0002532 a rdfs:Class ;
  rdfs:label "esophagus mucosa specimen" ;
  rdfs:comment "A specimen that is derived from esophagus mucosa."@en ;
  rdfs:subClassOf obo:OBI_0003483 .

obo:OBI_0002379 a rdfs:Class ;
  rdfs:label "son clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a person's male child."@en ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_2100151 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0003616 a rdfs:Class ;
  rdfs:label "antibody purification of MHC class I protein complex" ;
  rdfs:comment "An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class I protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003615 .

obo:OBI_0002563 a rdfs:Class ;
  rdfs:label "ethnicity inclusion criterion"@en ;
  rdfs:comment "An inclusion criteria that defines and states one or more ethnicities which, if met, makes an entity suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0003764 a rdfs:Class ;
  rdfs:label "macroscopic examination of material anatomical entity assay" ;
  rdfs:comment "An assay that performs a macroscopic assessment of a material anatomical entity using the sense of sight."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:CL_0000681 a rdfs:Class ;
  rdfs:label "radial glial cell" ;
  rdfs:comment "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." ;
  rdfs:subClassOf obo:CL_0002319 .

obo:OBI_0001754 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific chemokine (C-X-C motif) ligand 9 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects chemokine (C-X-C motif) ligand 9 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001459 , obo:OBI_0003115 .

obo:CHEBI_59050 a rdfs:Class ;
  rdfs:label "dimethyl sulfate" ;
  rdfs:comment "The dimethyl ester of sulfuric acid." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:PATO_0000141 a rdfs:Class ;
  rdfs:label "structure" ;
  rdfs:comment "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." ;
  rdfs:subClassOf obo:PATO_0000051 .

obo:OBI_0002698 a rdfs:Class ;
  rdfs:label "insecticide resistance bioassay" ;
  rdfs:comment "An insecticide resistance assay that is typically conducted to measure the effects of a substance on a living organism."@en ;
  rdfs:subClassOf obo:OBI_0002695 .

obo:MRO_0000991 a rdfs:Class ;
  rdfs:label "H2-Kb protein complex" ;
  rdfs:subClassOf obo:MRO_0001759 .

obo:OBI_0000522 a rdfs:Class ;
  rdfs:label "vial" ;
  rdfs:comment "A container made from solid material and primarily used for holding liquid."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0002968 a rdfs:Class ;
  rdfs:label "positive/negative ion switching metabolite profiling assay" ;
  rdfs:comment "A type of metabolic profiling assay which employs a hybrid dual quadrupole linear ion trap mass spectrometer for steady-state profiling of endogenous polar metabolites from organic extractions from biological samples."@en ;
  rdfs:subClassOf obo:OBI_0000366 .

obo:OBI_0600005 a rdfs:Class ;
  rdfs:label "collecting specimen from organism"@en ;
  rdfs:comment "a process with the objective to obtain a material entity that was part of an organism for potential future use in an investigation"@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:OBI_0002090 a rdfs:Class ;
  rdfs:label "rapid amplification of cDNA ends"@en ;
  rdfs:comment "A reverse transcribed polymerase chain reaction that is used to amplify a mRNA sequence between a defined internal site and the 5' or 3' end of the mRNA."@en ;
  rdfs:subClassOf obo:OBI_0000552 .

obo:OBI_0002547 a rdfs:Class ;
  rdfs:label "minor salivary gland specimen" ;
  rdfs:comment "A specimen that is derived from minor salivary gland."@en ;
  rdfs:subClassOf obo:OBI_0001479 , obo:OBI_0003483 .

obo:OBI_0003279 a rdfs:Class ;
  rdfs:label "eukaryota in pleural fluid datum" ;
  rdfs:comment "A pleural fluid microbiology datum that is about eukaryota."@en ;
  rdfs:subClassOf obo:OBI_0003258 .

obo:OBI_0002166 a rdfs:Class ;
  rdfs:label "tissue-based protein localization assay" ;
  rdfs:comment "A protein localization assay that determines the specific location of a protein in a living tissue sample."@en ;
  rdfs:subClassOf obo:OBI_0002165 .

obo:OBI_0003004 a rdfs:Class ;
  rdfs:label "flying adult arthropod collection process by passive interception" ;
  rdfs:comment "An adult arthropod specimen collection process that has the objective of collecting arthropods capable of flight, through the use of a barrier trap."@en ;
  rdfs:subClassOf obo:OBI_0002904 .

obo:OBI_0003695 a rdfs:Class ;
  rdfs:label "nested case-control investigation"@en ;
  rdfs:comment "A case–control investigation in which cases and controls are drawn from the population in a fully enumerated cohort."@en ;
  rdfs:subClassOf obo:OBI_0003692 .

obo:OBI_0002047 a rdfs:Class ;
  rdfs:label "enzyme-linked antibody" ;
  rdfs:comment "A processed material that is comprised of an antibody that is covalently linked to an enzyme through bioconjugation. The enzyme can be used as a detection method when the enzyme's reaction produces a detectable signal, for example a color change when the substrate is added."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0002819 a rdfs:Class ;
  rdfs:label "specimen pad" ;
  rdfs:comment "A sample collection device consisting of a soft flexible, absorbent pad usually made from natural material such as gauze or cotton, used to absorb specimen fluid or particulate matter."@en ;
  rdfs:subClassOf obo:OBI_0002814 .

obo:OBI_2100136 a rdfs:Class ;
  rdfs:label "venous blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:NCBITaxon_37124 a rdfs:Class ;
  rdfs:label "Chikungunya virus" ;
  rdfs:subClassOf obo:NCBITaxon_2732406 .

obo:OBI_0003735 a rdfs:Class ;
  rdfs:label "disease severity assay" ;
  rdfs:comment "An assay that measures the severity of a disease in an organism."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100116 a rdfs:Class ;
  rdfs:label "venous blood hemoglobin A1c assay" ;
  rdfs:comment "An assay that measures hemoglobin A1c in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0000661 a rdfs:Class ;
  rdfs:label "enzyme-linked immunosorbent assay" ;
  rdfs:comment "An analyte assay where binding of an enzyme linked antibody to a material entity that is immobilized on solid support is detected utilizing a chemiluminescent reaction. Depending on the setup, the enzyme-linked antibody could be binding directly to the analyte, or it serves as a secondary antibody detecting binding of the primary antibody to the analyte."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:PCO_0000000 a rdfs:Class ;
  rdfs:label "collection of organisms"@en ;
  rdfs:comment "A material entity that consists of two or more organisms, viruses, or viroids."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0002189 a rdfs:Class ;
  rdfs:label "local field potential recording" ;
  rdfs:comment "An extracellular electrophysiology assay where a microelectrode is placed in the extracellular space of brain tissue to measure action potential and compared to an electrode either outside or inside that tissue."@en ;
  rdfs:subClassOf obo:OBI_0000454 .

obo:OBI_0001139 a rdfs:Class ;
  rdfs:label "liquid chromatography instrument" ;
  rdfs:comment "A chromatography device that dissolves a mixture in liquid mobile phase to separate the analyte to be measured from other molecules in the mixture and allows it to be isolated"@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:GO_0044808 a rdfs:Class ;
  rdfs:label "oncostatin M production" ;
  rdfs:comment "The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000556 a rdfs:Class ;
  rdfs:label "isocratic pump system" ;
  rdfs:comment "A pump system optimized for isocratic chromatography."@en ;
  rdfs:subClassOf obo:OBI_0000589 .

obo:OBI_0002581 a rdfs:Class ;
  rdfs:label "merged aligned sequence data" ;
  rdfs:comment "The results of a data transformation of sequence data in which files containing aligned sequence data are merged together"@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001977 a rdfs:Class ;
  rdfs:label "cytometry assay" ;
  rdfs:comment "An assay that counts and/or measures characteristics of cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000641 a rdfs:Class ;
  rdfs:label "JEOL ECA NMR spectrometer" ;
  rdfs:comment "The ECA series of NMR spectrometers is a high performance, research grade NMR system configurable to a wide range off applications. The ECA NMR is available from 300 to 930 MHz field strengths and is 1GHz ready. The system is designed around a modular, digital NMR electronics chassis controlled from a UNIX or Windows workstation and acquisition system. Both the workstation and spectrometer may be connected to a standard network, allowing seamless remote operation anywhere in the world."@en ;
  rdfs:subClassOf obo:OBI_0000600 .

obo:GO_0040008 a rdfs:Class ;
  rdfs:label "regulation of growth" ;
  rdfs:comment "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_1000048 a rdfs:Class ;
  rdfs:label "transgenic organism"@en ;
  rdfs:comment "a transgenic organism is material entity which derives from an organism which has been modified to express a gene not normally part of it"@en ;
  rdfs:subClassOf obo:OBI_0302859 .

obo:OBI_0002766 a rdfs:Class ;
  rdfs:label "cytokine assay" ;
  rdfs:comment "An analyte assay to study presence, concentration, or amount of cytokines."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0000025 a rdfs:Class ;
  rdfs:label "reference substance role"@en ;
  rdfs:comment "a role inhering in a material entity that is realized when  characteristics or responses elicited by the substance are used for comparison or reference."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000257 a rdfs:Class ;
  rdfs:label "DNA extraction"@en ;
  rdfs:comment "A DNA extraction is a nucleic acid extraction where the desired output material is DNA."@en ;
  rdfs:subClassOf obo:OBI_0666667 .

obo:OBI_2100228 a rdfs:Class ;
  rdfs:label "chem11 venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:OBI_0002906 a rdfs:Class ;
  rdfs:label "animal-biting outdoor arthropod specimen collection by aspiration" ;
  rdfs:comment "An animal-biting arthropod specimen collection by aspiration that occurs outside a building."@en ;
  rdfs:subClassOf obo:OBI_0002905 .

obo:OBI_0200115 a rdfs:Class ;
  rdfs:label "pearson correlation coefficient calculation"@en ;
  rdfs:comment "A pearson correlation coefficient calculation is a similarity calculation which attaches to each pair of random variables X and Y the ratio of their covariance by the product of their standard deviations. Given a series of n measurements of X and Y written as x_i and y_i where i = 1, 2, ..., n, then their Pearson correlation coefficient refers to the \"sample correlation coefficient\" and is written as the sum over i of the ratios (x_i-xbar)*(y_i-ybar)/((n-1)*s_x*s_y) where xbar and ybar are the sample means of X and Y , s_x and s_y are the sample standard deviations of X and Y. The closer the pearson correlation coefficient is to 1, the more similar the inputs are considered."@en ;
  rdfs:subClassOf obo:OBI_0200113 .

obo:UBERON_0002512 a rdfs:Class ;
  rdfs:label "corpus luteum" ;
  rdfs:comment "A transient endocrine gland that develops from the postovulatory or atretic follicles and secretes progesterone; it is thought to be related to egg retention[PMID]." ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:OBI_0001869 a rdfs:Class ;
  rdfs:label "Illumina BeadChip" ;
  rdfs:comment "An array that consists of 3-micron silica beads that self assemble in microwells on either of two materials: fiber optic bundles or planar silica slides."@en ;
  rdfs:subClassOf obo:OBI_0001865 .

obo:OBI_0002796 a rdfs:Class ;
  rdfs:label "medical gown" ;
  rdfs:comment "A personal protective clothing item which is a gown worn by a medical professional in order to provide a barrier between patient and professional."@en ;
  rdfs:subClassOf obo:OBI_0002800 .

obo:UBERON_0002465 a rdfs:Class ;
  rdfs:label "lymphoid system" ;
  rdfs:comment "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." ;
  rdfs:subClassOf obo:UBERON_0000467 .

obo:OBI_0003526 a rdfs:Class ;
  rdfs:label "tandem walk assessment" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain balance while walking in a straight line placing steps in tandem."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0001787 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific vascular endothelial growth factor production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects vascular endothelial growth factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001570 , obo:OBI_0003115 .

obo:OBI_0000167 a rdfs:Class ;
  rdfs:label "electronic case report form"@en ;
  rdfs:comment "An electronic case report form is a digital document used to record all of the protocol required information to be reported for each trial subject. An eCRF has the property that it can be audited and compliant with requirements of 21 CFR Part 11."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0200179 a rdfs:Class ;
  rdfs:label "class prediction objective"@en ;
  rdfs:comment """A class prediction objective (sometimes called supervised classification) is a data transformation objective where the aim is to create a predictor from training data through a machine learning technique. The training data consist of pairs of objects (typically vectors of attributes) and
class labels for these objects. The resulting predictor can be used to attach class labels to any valid novel input object. Depending on usage, the prediction can be definite or probabilistic. A classification is learned from the training data and can then be tested on test data."""@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0003566 a rdfs:Class ;
  rdfs:label "lymph node administration" ;
  rdfs:comment "An intralymphatic administration in which the substance is administered into a lymph node."@en ;
  rdfs:subClassOf obo:OBI_0003565 .

obo:MRO_0000975 a rdfs:Class ;
  rdfs:label "H2-IAg7 protein complex" ;
  rdfs:subClassOf obo:MRO_0000971 .

obo:CL_0000077 a rdfs:Class ;
  rdfs:label "mesothelial cell" ;
  rdfs:comment "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:OBI_0400079 a rdfs:Class ;
  rdfs:label "optical filter" ;
  rdfs:comment "An optical filter is an optical subsystem that selectively transmits light having certain properties (often, a particular range of wavelengths, that is, range of colours of light), while blocking the remainder. They are commonly used in photography, in many optical instruments, and to colour stage lighting Optical filters can be arranged to segregate and collect light by wave length."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0000719 a rdfs:Class ;
  rdfs:label "vaccine production" ;
  rdfs:comment "A planned process with the objective to create a vaccine."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000545 a rdfs:Class ;
  rdfs:label "column compartment" ;
  rdfs:comment "For chromatography analyses, the ability to maintain a stable column environment regardless of ambient temperature fluctuations is critical for maintaining retention time precision. In order to ensure such stable conditions at different chromatography steps a column compartment can be installed that ensures e.g. stable temperature of the column in a given step."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_0002570 a rdfs:Class ;
  rdfs:label "nCounter Mouse miRNA Expression array" ;
  rdfs:comment "A mouse array which is manufacutred by NanoString Technologies. Built upon color-coded molecular barcodes technology, the array profiles miRNA with increased specificity and sensitivty than microarrays."@en ;
  rdfs:subClassOf obo:OBI_0001865 .

obo:OBI_0001266 a rdfs:Class ;
  rdfs:label "DNA methylation profiling by high throughput sequencing assay" ;
  rdfs:comment "A DNA methylation profiling assay in which the methylation state of DNA is determined and can be compared between samples using sequencing based technology"@en ;
  rdfs:subClassOf obo:OBI_0000634 .

obo:OBI_0000533 a rdfs:Class ;
  rdfs:label "affinity column" ;
  rdfs:comment "An affinity column is a chromatography column that is used in affinity chromatography. Differences in the affinity of molecules to be separated to a stationary phase are used for discriminate retention."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0000652 a rdfs:Class ;
  rdfs:label "material combination" ;
  rdfs:comment "is a material processing with the objective to combine two or more material entities as input into a single material entity as output."@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0002141 a rdfs:Class ;
  rdfs:label "volume measurement assay" ;
  rdfs:comment "An assay to determine the volume of an evaluant."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001493 a rdfs:Class ;
  rdfs:label "cell bound MHC competitive binding assay of a MHC:ligand complex using T cell epitope recognition" ;
  rdfs:comment "A cell bound MHC binding assay that uses a T cell epitope recognition assay."@en ;
  rdfs:subClassOf obo:OBI_0001550 .

obo:PR_000025467 a rdfs:Class ;
  rdfs:label "guanyl-specific ribonuclease T1" ;
  rdfs:comment "A protein that is a translation product of the Aspergillus oryzae RIB40 rntA gene or a 1:1 ortholog thereof." ;
  rdfs:subClassOf obo:PR_000000001 .

obo:OBI_0003391 a rdfs:Class ;
  rdfs:label "Affymetrix Mouse Genome 430 2.0 Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, which includes complete coverage of the GeneChip Mouse Expression Set 430, for analysis of over 39,000 transcripts and variants from more than 34,000 well-characterized mouse genes and UniGene clusters, on a single array. The sequences for this array were selected from GenBank™, dbEST, and RefSeq., and sequence clusters cretaed from the UniGene database."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0400028 a rdfs:Class ;
  rdfs:label "CytoSence" ;
  rdfs:comment "A CytoSense is a flow_cytometer_analyser manufactured by Cyto Buoy Inc. They are a single laser, multi parameter instrument. Various types of micro-laser are offered; available measuring parameters are forward light scatter, side scatter, and fluorescence (max. 9 colour bands). The current series have 5 parameters. The CytoSense is the basic instrument, which can be used for normal laboratory applications, as well as for autonomous monitoring with internal data logging or direct data transmission. The special instrument design and its splashproof housing allow operation on moving platforms and outdoor sites."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0000430 a rdfs:Class ;
  rdfs:label "plasmid"@en ;
  rdfs:comment """plasmid = DNA and has_quality circular and has_function
(is_realized_as some gene expression) GO:0010467"""@en ;
  rdfs:subClassOf obo:CHEBI_4705 .

obo:OBI_0002542 a rdfs:Class ;
  rdfs:label "aorta specimen" ;
  rdfs:comment "A specimen that is derived from aorta."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001870 a rdfs:Class ;
  rdfs:label "Illumina methylation BeadChip" ;
  rdfs:comment "A BeadChip made for an analyte assay that generates information about DNA methylation."@en ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:OBI_0200145 a rdfs:Class ;
  rdfs:label "intra subgraph connectivity calculation"@en ;
  rdfs:comment "A network subgraph quality calculation in which an input data set describing internal nodes, edges and node degrees is used to determine the average node degree within the subgraph."@en ;
  rdfs:subClassOf obo:OBI_0200137 .

obo:OBI_2100252 a rdfs:Class ;
  rdfs:label "POC chem8 arterial blood potassium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of potassium in arterial blood as part of a POC chem8 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100004 .

obo:OBI_2100056 a rdfs:Class ;
  rdfs:label "automated differential venous blood basophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of basophils in venous blood as part of a automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003021 , obo:OBI_0003040 .

obo:GO_0035399 a rdfs:Class ;
  rdfs:label "helper T cell enhancement of B cell mediated immune response" ;
  rdfs:comment "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell." ;
  rdfs:subClassOf obo:GO_0035397 .

obo:OBI_0001810 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific granulysin release by T cells" ;
  rdfs:comment "A T cell epitope specific cytotoxic T cell degranulation assay that detects granulysin release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001269 .

obo:CL_0000066 a rdfs:Class ;
  rdfs:label "epithelial cell" ;
  rdfs:comment "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." ;
  rdfs:subClassOf obo:CL_0000000 .

obo:OBI_0400008 a rdfs:Class ;
  rdfs:label "flow cytometer analyzer" ;
  rdfs:comment "An analyser is a flow_cytometer that is used to measure properties of particles (whole cells, nuclei, chromosomes, diatoms, plankton, bacteria, viruses) by moving these particles through a detection chamber. An analyser is used to collect data for analysis."@en ;
  rdfs:subClassOf obo:OBI_0400044 .

obo:OBI_0000361 a rdfs:Class ;
  rdfs:label "ion source" ;
  rdfs:comment "An ion source is a device that is part of a mass spectrometer that ionizes the material under analysis. The ions are then transported by magnetic or electric fields to the mass analyzer.  Techniques for ionization have been key to determining what types of samples can be analyzed by mass spectrometry. Electron ionization and chemical ionization are used for gases and vapors. In chemical ionization sources, the material is ionized by chemical ion-molecule reactions during collisions in the source. Two techniques often used with liquid and solid biological samples include electrospray ionization (due to John Fenn PMID 2675315.) and matrix-assisted laser desorption/ionization (MALDI, due to M. Karas and F. Hillenkamp (Measuring Mass: From Positive Rays to Proteins by Michael A. Grayson (Editor) (ISBN 0-941901-31-9)))."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:CLO_0000018 a rdfs:Class ;
  rdfs:label "mortal cell line cell" ;
  rdfs:comment "A cell line cell that is capable of replicating a limited number of times in culture before undergoing senescence." ;
  rdfs:subClassOf obo:CLO_0000001 .

obo:GO_0019904 a rdfs:Class ;
  rdfs:label "protein domain specific binding" ;
  rdfs:comment "Binding to a specific domain of a protein." ;
  rdfs:subClassOf obo:OBI_0001588 .

obo:CHEBI_59054 a rdfs:Class ;
  rdfs:label "N-methylisatoic anhydride" ;
  rdfs:comment "A 3,1-benzoxazin-1,4-dione having an <em>N</em>-methyl substituent." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002065 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific granzyme B release by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects epitope specific granzyme B release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001436 , obo:OBI_0003115 .

obo:OBI_0000623 a rdfs:Class ;
  rdfs:label "NMR spectroscopy assay" ;
  rdfs:comment "An assay that exploits the magnetic properties of certain nuclei (those with a spin) to resonate when placed in particular magnetic field conditions. Instruments recording NMR spectrum and sets of analysis can be used to deduce identity of chemical as well as composition of complex chemical mixtures."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001188 a rdfs:Class ;
  rdfs:label "epitope disease exacerbation experiment" ;
  rdfs:comment "An efficacy of epitope intervention experiment that tests the ability of inducing an epitope immune response to increase the severity of an existing disease in the host."@en ;
  rdfs:subClassOf obo:OBI_0001178 .

obo:OBI_0003046 a rdfs:Class ;
  rdfs:label "free-standing window trap" ;
  rdfs:comment "An arthropod trap that consists of a transparent window placed in a box that holds a liquid solution deadly to arthropods. This trap is designed to stop an arthropod in flight, causing it to fall into the liquid and die."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0001288 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific lymphotoxin A production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects lymphotoxin A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001246 , obo:OBI_0001327 .

obo:OBI_0001392 a rdfs:Class ;
  rdfs:label "in vivo assay measuring epitope specific T cell killing" ;
  rdfs:comment "An in vivo cell killing assay that measures the killing of antigen presenting cells (APC) by T cells whose TCR recognizes an epitope presented by the APC."@en ;
  rdfs:subClassOf obo:OBI_0000883 , obo:OBI_0001484 , obo:OBI_1110130 .

obo:OBI_0002148 a rdfs:Class ;
  rdfs:label "surface HBV antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect antibodies that bind to hepatitis B virus (HBV) surface antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:UBERON_0006911 a rdfs:Class ;
  rdfs:label "digestive system secreted substance" ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:GO_0051276 a rdfs:Class ;
  rdfs:label "chromosome organization" ;
  rdfs:comment "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001494 a rdfs:Class ;
  rdfs:label "linear amplification"@en ;
  rdfs:comment "An enzymatic amplification which amplifies nucleic acid sequence by making many copies off the same template."@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBI_0001728 a rdfs:Class ;
  rdfs:label "ELISA measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that measures the dissociation constant [KD] of an antigen binding with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001708 .

obo:OBI_0400010 a rdfs:Class ;
  rdfs:label "argon ion laser" ;
  rdfs:comment "An argon-ion laser is an ion laser that uses argon ions as the lasing medium. These lasers are used primarily to emit light at wave lengths of 458 nm, 488 nm or 514.5 nm, though it is possible to use them to emit several wavelengths of blue and green light. Argon-ion lasers can emit light at many different wave lenghts, and excite a number of different flourochromes."@en ;
  rdfs:subClassOf obo:OBI_0400060 .

obo:OBI_0003380 a rdfs:Class ;
  rdfs:label "placental blood specimen" ;
  rdfs:comment "A specimen that is derived from placental blood."@en ;
  rdfs:subClassOf obo:OBI_0000655 .

obo:OBI_0000480 a rdfs:Class ;
  rdfs:label "Bruker high resolution probe" ;
  rdfs:comment "BRUKER BIOSPIN's experienced Research & Development group not only delivers top-performance probes for the more common experiments, but also a wealth of special probes for almost any application. For high resolution (HR) NMR we offer probes with a variety of important characteristics and features."@en ;
  rdfs:subClassOf obo:OBI_0000561 .

obo:OBI_0001579 a rdfs:Class ;
  rdfs:label "assay measuring binding of a cell-lysate-MHC:ligand complex" ;
  rdfs:comment "A qualitative binding assay that detects the binding of a cell-lysate-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002072 .

obo:OBI_0003160 a rdfs:Class ;
  rdfs:label "lymphocyte percentage assay" ;
  rdfs:comment "A lymphocyte assay that measures the percentage of lymphocytes in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003024 .

obo:OBI_0000578 a rdfs:Class ;
  rdfs:label "NMR sample tube" ;
  rdfs:comment "The sample-tube holds the NMR sample and sits in the nmr probe. It is usually a glass tube of 5-20mm diameter."@en ;
  rdfs:subClassOf obo:OBI_0000836 .

obo:OBI_0002124 a rdfs:Class ;
  rdfs:label "H&E slide staining"@en ;
  rdfs:comment "A staining using hematoxylin and eosin. The staining is applied to fixed specimens on slides to observe the whole structure and morphology of cells in a tissue; nuclei are stained dark blue/purple while cytoplasm is stained pink."@en ;
  rdfs:subClassOf obo:OBI_0302887 .

obo:OBI_0001220 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-10 production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interleukin-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001209 .

obo:OBI_0001747 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-1 alpha production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001388 , obo:OBI_0003115 .

obo:OBI_0003312 a rdfs:Class ;
  rdfs:label "RNA-DNA split-pool recognition of interactions and tag extension assay" ;
  rdfs:comment "A split-pool recognition of interactions and tag extension (SPRITE) assay in which RNA in the cross-linked complexes is converted to cDNA before the initial splitting step, allowing analysis of RNA-DNA interactions."@en ;
  rdfs:subClassOf obo:OBI_0003310 .

obo:OBI_0001717 a rdfs:Class ;
  rdfs:label "B cell epitope specific antibody-dependent cellular cytotoxicity" ;
  rdfs:comment "antibody-dependent cellular cytotoxicity resulting from antibody binding to epitope"@en ;
  rdfs:subClassOf obo:GO_0001788 .

obo:OBI_0003425 a rdfs:Class ;
  rdfs:label "alkaline phosphatase activity level assay" ;
  rdfs:comment "An enzymatic activity level assay that measures the activity of alkaline phosphatase in a sample."@en ;
  rdfs:subClassOf obo:OBI_0003422 .

obo:OBI_1110163 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific interleukin-18 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects interleukin-18 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001380 .

obo:OBI_0003630 a rdfs:Class ;
  rdfs:label "antibody purification of H2-Kd protein complex" ;
  rdfs:comment "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Kd protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003627 , obo:OBI_0003632 .

obo:OBI_0002372 a rdfs:Class ;
  rdfs:label "family clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a blood relative."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0200131 a rdfs:Class ;
  rdfs:label "quantitative node degree calculation"@en ;
  rdfs:comment "A node quality calculation in which an input data set describing object nodes and quantitative relationship edges between object nodes is used to sum all of the quantitative relationships of an individual object node."@en ;
  rdfs:subClassOf obo:OBI_0200129 .

obo:OBI_2100016 a rdfs:Class ;
  rdfs:label "alanine aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of alanine aminotransferase"@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_2100023 .

obo:GO_0006282 a rdfs:Class ;
  rdfs:label "regulation of DNA repair" ;
  rdfs:comment "Any process that modulates the frequency, rate or extent of DNA repair." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:GO_0001508 a rdfs:Class ;
  rdfs:label "action potential" ;
  rdfs:comment "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:GO_0032628 a rdfs:Class ;
  rdfs:label "interleukin-24 production" ;
  rdfs:comment "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000698 a rdfs:Class ;
  rdfs:label "obsolete_DNA ligase" ;
  rdfs:comment "A DNA ligase is an enzyme that covalently joins two compatible pieces of DNA through the cleavage of an ATP molecule"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0400019 a rdfs:Class ;
  rdfs:label "charge plate" ;
  rdfs:comment "Part of the fluidics subsystem. Charge plates are used or sorters. They create an charged electric field when particles deemed to be desired for further analysis are shaken form the piexo electric crystal. The charged particles are drawn toward the charged plate, and the altered drop location causes the particles to fall into a collection tube. Charge plates enable sorting."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_2100308 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood methemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of methemoglobin in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100040 .

obo:CHEBI_17230 a rdfs:Class ;
  rdfs:label "homocysteine" ;
  rdfs:comment "A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0003646 a rdfs:Class ;
  rdfs:label "antibody purification of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype" ;
  rdfs:comment "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003636 .

obo:OBI_0002159 a rdfs:Class ;
  rdfs:label "HCV nucleic acid testing" ;
  rdfs:comment "An analyte assay that is meant to detect hepatitis C virus (HCV) nucleic acids."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OGMS_0000015 a rdfs:Class ;
  rdfs:label "clinical history" ;
  rdfs:comment "A series of statements representing health-relevant qualities of a patient and of a patient's family."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0001821 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-22 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-22 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001217 , obo:OBI_0600031 .

obo:OBI_0001563 a rdfs:Class ;
  rdfs:label "material processing service" ;
  rdfs:comment "A service in which a service provider makes physical changes to a specified input material entity with the objective of producing a new material entity form input materials, or modifying the input material entity, and returning this as output to the service consumer."@en ;
  rdfs:subClassOf obo:OBI_0001528 .

obo:OBI_0400085 a rdfs:Class ;
  rdfs:label "piezo electric crystal"@en ;
  rdfs:comment "Apparatus in the fluidic subsystem of sorters that vibrates to break up the stream coming out of the flow chamber into droplets for sorting. The peizo electric crystal vibrates in a manner that breaks off droplets at regular intervals. Not all droplets contain a cell."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0200030 a rdfs:Class ;
  rdfs:label "median centering"@en ;
  rdfs:comment "A median centering is a data transformation that takes as input an n-dimensional (real) vector, performs a median calculation on its components, and subtracts the resulting median from each component of the input."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0003806 a rdfs:Class ;
  rdfs:label "electrocardiograph" ;
  rdfs:comment "An instrument for recording the changes of electrical potential occurring during the heartbeat used especially in diagnosing abnormalities of heart action."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0003084 a rdfs:Class ;
  rdfs:label "specimen collection time post infection" ;
  rdfs:comment "A specimen collection time measurement datum that is the measure of a time when specimens are collected after an infection starts."@en ;
  rdfs:subClassOf obo:OBI_0001619 .

obo:OBI_0001235 a rdfs:Class ;
  rdfs:label "transcription profiling by tiling array assay" ;
  rdfs:comment "A transcription profiling by array assay that uses a tiling path array."@en ;
  rdfs:subClassOf obo:OBI_0001463 .

obo:OBI_0001601 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific intracellular cytokine staining (ICS) IL-21 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-21 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001237 , obo:OBI_0003115 .

obo:OBI_0000319 a rdfs:Class ;
  rdfs:label "material to be added role"@en ;
  rdfs:comment "A role of a material entity that is realized in an \"adding a material entity into a target\" process where the bearer of the role is added into another material entity (the target)."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000888 a rdfs:Class ;
  rdfs:label "nuclear RNA extraction" ;
  rdfs:comment "A RNA extraction process in which the desired output material is RNA in the nucleus."@en ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBI_0200134 a rdfs:Class ;
  rdfs:label "node shortest path identification"@en ;
  rdfs:comment "A node quality calculation in which a path describing the shortest path needed to transverse through connected nodes and edges to arrive at a specific target node in the network."@en ;
  rdfs:subClassOf obo:OBI_0200129 .

obo:OBI_0001311 a rdfs:Class ;
  rdfs:label "X-ray crystallography assay determining the 3D structure of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A X-ray crystallography 3D molecular structure determination assay that characterizes the 3-dimensional molecular structure of a T cell epitope:MHC:TCR complex."@en ;
  rdfs:subClassOf obo:OBI_0000912 , obo:OBI_0001999 .

obo:OBI_0002414 a rdfs:Class ;
  rdfs:label "postmenopausal status" ;
  rdfs:comment "A menopausal status indicating that it has been more than 12 months since the last menstrual period with no prior hysterectomy or that there has been a prior bilateral oophorectomy."@en ;
  rdfs:subClassOf obo:OBI_0002410 .

obo:OBI_0003565 a rdfs:Class ;
  rdfs:label "intralymphatic administration" ;
  rdfs:comment "An administration of a substance into the lymphatic system of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0000045 a rdfs:Class ;
  rdfs:label "waiting"@en ;
  rdfs:comment "A planned process where an agent does not take any new actions towards a particular objective for a period of time until a set of conditions is met."@en ;
  rdfs:subClassOf obo:OBI_0600009 .

obo:OBI_0001948 a rdfs:Class ;
  rdfs:label "sequence assembly name"@en ;
  rdfs:comment "A textual entity that is used to denote a sequence assembly."@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:UBERON_0001836 a rdfs:Class ;
  rdfs:label "saliva" ;
  rdfs:comment "A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions." ;
  rdfs:subClassOf obo:UBERON_0000463 .

obo:MRO_0000973 a rdfs:Class ;
  rdfs:label "H2-IAd protein complex" ;
  rdfs:subClassOf obo:MRO_0000971 .

obo:OBI_0003070 a rdfs:Class ;
  rdfs:label "specimen collection protocol" ;
  rdfs:comment "A protocol that specifies processes to fulfill a specimen collection objective."@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:OBI_0600016 a rdfs:Class ;
  rdfs:label "pooling specimens"@en ;
  rdfs:comment "physical combination of several instances of like material"@en ;
  rdfs:subClassOf obo:OBI_0000652 .

obo:OBI_0002617 a rdfs:Class ;
  rdfs:label "national registry"@en ;
  rdfs:comment "An information content entity that contains information about a nationwide group of individuals."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0000392 a rdfs:Class ;
  rdfs:label "information processor function"@en ;
  rdfs:comment "An information processor function is a function that converts information from one form to another, by a lossless process or an extraction process."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_2100076 a rdfs:Class ;
  rdfs:label "CBC venous blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a CBC order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0001158 a rdfs:Class ;
  rdfs:label "age determination assay" ;
  rdfs:comment "An assay that determines the duration of part of the life of an organism, where the initial time point is the beginning of some transitional state (such as birth or when planted)."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000507 a rdfs:Class ;
  rdfs:label "gas generator" ;
  rdfs:comment "An instrument that generates gases for use with the gas chromatograph. Previously gas was obtained from gas tanks or gas cylinders. However, over the past decade the use of gas generators have become more popular as it avoids having gases at high pressure in the laboratory which is perceived by some as potentially dangerous. In addition, the use of a hydrogen generator avoids the use of a cylinder of hydrogen at high pressure which is also perceived by some as a serious fire hazard despite the fact that they have been used in laboratories, quite safely for nearly a century."@en ;
  rdfs:subClassOf obo:OBI_0000542 .

obo:UBERON_0001555 a rdfs:Class ;
  rdfs:label "digestive tract" ;
  rdfs:comment "A tube extending from the mouth to the anus." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0003268 a rdfs:Class ;
  rdfs:label "bacteria in induced sputum datum" ;
  rdfs:comment "An induced sputum microbiology datum that is about bacteria."@en ;
  rdfs:subClassOf obo:OBI_0003251 .

obo:OBI_0003813 a rdfs:Class ;
  rdfs:label "organism development assay in late embryo based on examination of surface structure" ;
  rdfs:comment "An organism development assay in late embryo that evaluates only the external surface structure of the organism"@en ;
  rdfs:subClassOf obo:OBI_0003767 .

obo:OBI_0002700 a rdfs:Class ;
  rdfs:label "insecticide resistance by detecting beta esterase activity assay" ;
  rdfs:comment "An insecticide resistance by detecting enzyme activity assay that measures activity of beta esterase."@en ;
  rdfs:subClassOf obo:OBI_0002697 .

obo:CHEBI_16134 a rdfs:Class ;
  rdfs:label "ammonia" ;
  rdfs:comment "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0200078 a rdfs:Class ;
  rdfs:label "descriptive statistical calculation objective"@en ;
  rdfs:comment "A descriptive statistical calculation objective is a data transformation objective which concerns any calculation intended to describe a feature of a data set, for example, its center or its variability."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002778 a rdfs:Class ;
  rdfs:label "tracheal aspirate specimen" ;
  rdfs:comment "A specimen that is collected with a suctioning tube from the trachea."@en ;
  rdfs:subClassOf obo:OBI_0002781 , obo:OBI_0002783 .

obo:OBI_0001241 a rdfs:Class ;
  rdfs:label "cell culture analyte detection bioassay measuring epitope specific interleukin-4 production by T cells" ;
  rdfs:comment "A reporter cell line analyte detection bioassay that detects interleukin-4 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000904 , obo:OBI_0001450 .

obo:OBI_0003075 a rdfs:Class ;
  rdfs:label "age since birth at time of enrollment" ;
  rdfs:comment "An age since birth measurement datum at the time of subject enrollment."@en ;
  rdfs:subClassOf obo:OBI_0001169 .

obo:UBERON_0002037 a rdfs:Class ;
  rdfs:label "cerebellum" ;
  rdfs:comment "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." ;
  rdfs:subClassOf obo:UBERON_0000481 .

obo:OBI_0002791 a rdfs:Class ;
  rdfs:label "face shield" ;
  rdfs:comment "A personal protective device used to protect the wearer's entire face (or part of it) from hazards such as flying objects and road debris, chemical splashes, or alternately potentially infectious materials."@en ;
  rdfs:subClassOf obo:OBI_0002786 .

obo:CHEBI_4705 a rdfs:Class ;
  rdfs:label "double-stranded DNA" ;
  rdfs:subClassOf obo:CHEBI_16991 .

obo:IAO_0000594 a rdfs:Class ;
  rdfs:label "software application"@en ;
  rdfs:comment "A software application is software that can be directly executed by some processing unit."@en ;
  rdfs:subClassOf obo:IAO_0000010 .

obo:OBI_0001508 a rdfs:Class ;
  rdfs:label "sampling time measurement datum"@en ;
  rdfs:comment "A time measurement datum when an observation is made or a sample is taken from a material as measured from some reference point."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:UBERON_0000305 a rdfs:Class ;
  rdfs:label "amnion" ;
  rdfs:comment "The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:GO_0071613 a rdfs:Class ;
  rdfs:label "granzyme B production" ;
  rdfs:comment "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0003795 a rdfs:Class ;
  rdfs:label "adenosine deaminase activity assay" ;
  rdfs:comment "An analyte assay measuring adenosine deaminase activity in a sample."@en ;
  rdfs:subClassOf obo:OBI_2100023 .

obo:OBI_1110157 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific granulocyte macrophage colony-stimulating factor production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects granulocyte macrophage colony stimulating factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001233 .

obo:OBI_0001405 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects macrophage inflammatory protein-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001333 , obo:OBI_0003115 .

obo:OBI_1110124 a rdfs:Class ;
  rdfs:label "assay measuring qualitative binding of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "An assay that detects the binding of a MHC:epitope complex with a T cell receptor, and produces a qualitative measurement of the binding as an output."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110037 .

obo:OBI_2100239 a rdfs:Class ;
  rdfs:label "chem16 venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:OBI_0302902 a rdfs:Class ;
  rdfs:label "immobilization"@en ;
  rdfs:comment "immbolization is a process by which material entity become (possibly covalently but not necessarily) attached to the surface of another material entity used a substratum."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:PATO_0002243 a rdfs:Class ;
  rdfs:label "fluid flow rate" ;
  rdfs:comment "A physical quality inhering in a fluid (liquid or gas) by virtue of the amount of fluid which passes through a given surface per unit time." ;
  rdfs:subClassOf obo:PATO_0001574 .

obo:OBI_0001963 a rdfs:Class ;
  rdfs:label "target subfragment specification"@en ;
  rdfs:comment "is a directive information specifying a genomic region, possibly located in a coding genomic region, which is the focus of a planned process such as an assay, for instance in a environmental gene survey"@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0200082 a rdfs:Class ;
  rdfs:label "longitudinal data analysis"@en ;
  rdfs:comment "Longitudinal analysis is a data transformation used to perform repeated observations of the same items over long periods of time."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_2100255 a rdfs:Class ;
  rdfs:label "POC chem8 arterial blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in arterial blood as part of a POC chem8 order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0000067 a rdfs:Class ;
  rdfs:label "evaluant role"@en ;
  rdfs:comment "a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0003095 a rdfs:Class ;
  rdfs:label "decoding amplified targeted transcripts with fluorescence in situ hybridization assay" ;
  rdfs:comment "A fluorescence in-situ hybridization assay which involves multiplex in situ digital quantification of targeted RNA transcripts in fresh or frozen tissue providing an understanding of the spatial organization of different cell types."@en ;
  rdfs:subClassOf obo:OBI_0000424 , obo:OBI_0003094 .

obo:IAO_8000020 a rdfs:Class ;
  rdfs:label "EL++ ontology module"@en ;
  rdfs:subClassOf obo:IAO_8000019 .

obo:OBI_0003132 a rdfs:Class ;
  rdfs:label "endonuclease mediated mutagenesis" ;
  rdfs:comment "A directed mutagenesis in which guide RNAs and an endonuclease (cas9, TALEN) are used to introduce a mutation at a specific location in a gene."@en ;
  rdfs:subClassOf obo:OBI_0003131 .

obo:OBI_0001524 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring equilibrium association constant [KA] to determine direct binding of a cell-bound-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that measures equilibrium association constant (KA) to detect the direct binding of a cell-bound-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001987 .

obo:OBI_0400030 a rdfs:Class ;
  rdfs:label "dichroic filter" ;
  rdfs:comment "A dichroic filter is an optical filter which is used to selectively pass light of a small range of colors while reflecting other colors. A dichroic filter passes the specified range of light whereas a dichroic mirror reflects the specified range of light."@en ;
  rdfs:subClassOf obo:OBI_0400079 .

obo:OBI_0001595 a rdfs:Class ;
  rdfs:label "X-ray crystallography assay determining the 3D structure of a MHC:ligand complex" ;
  rdfs:comment "A X-ray crystallography 3D molecular structure determination assay that characterizes the 3-dimensional molecular structure of a MHC:ligand complex."@en ;
  rdfs:subClassOf obo:OBI_0000912 , obo:OBI_0002050 .

obo:OBI_0003301 a rdfs:Class ;
  rdfs:label "DNase Hi-C assay" ;
  rdfs:comment "A Hi-C assay in which DNase I is used for digesting DNA fragments rather than a restriction enzyme, which can result in a higher resolution of mapped chromosome contacts."@en ;
  rdfs:subClassOf obo:OBI_0002440 .

obo:GO_0032617 a rdfs:Class ;
  rdfs:label "obsolete interleukin-14 production" ;
  rdfs:comment "OBSOLETE. The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_2100065 a rdfs:Class ;
  rdfs:label "CBC with automated differential venous blood hematocrit assay" ;
  rdfs:comment "A cytometry assay that measures the proportion of red blood cells in venous blood as part of a CBC with automated differential order"@en ;
  rdfs:subClassOf obo:OBI_0003018 , obo:OBI_0003040 .

obo:OBI_0001300 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001445 , obo:OBI_0003115 .

obo:OBI_2100350 a rdfs:Class ;
  rdfs:label "free venous blood T3 assay" ;
  rdfs:comment "An analyte assay that measures the abundance of T3 in venous blood as part of a free order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100046 .

obo:OBI_0400026 a rdfs:Class ;
  rdfs:label "CyFlow Space" ;
  rdfs:comment "A CyFlow_Space is a flow_cytometer_sorter manufactured by Partec. Its specs are: 8optical parameters, 6 colours:FSC, SSC, FL1-FL6 , 3laser light sources: 200mW@488nm blue solid state laser 25mW@635nm red diode laser 50mW@405nm violet or 8mW@375nm ultraviolet diode laser _ultracompact desktop high end instrument. Parallel 16bit digital pulse processing. The CyFlow Space is a 6-Colour FCM System and Cell Sorter for Clinical Routine and Research."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0000798 a rdfs:Class ;
  rdfs:label "capsule shell" ;
  rdfs:comment "a small rounded gelatinous container"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0002780 a rdfs:Class ;
  rdfs:label "nasal aspirate specimen" ;
  rdfs:comment "A specimen that is collected with a suctioning tube from the nasal cavity."@en ;
  rdfs:subClassOf obo:OBI_2000006 .

obo:GO_0036262 a rdfs:Class ;
  rdfs:label "granulysin production" ;
  rdfs:comment "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0001534 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring competitive binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that detects loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001555 .

obo:IDO_0000450 a rdfs:Class ;
  rdfs:label "pathogenic disposition"@en ;
  rdfs:comment "A disposition to initiate processes that result in a disorder."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_0000650 a rdfs:Class ;
  rdfs:label "differential expression analysis data transformation"@en ;
  rdfs:comment "A differential expression analysis data transformation is a data transformation that has an objective of differential expression analysis.  Frequently this data transformation involves summarizing or otherwise aggregating signals from various samples categorized into groups, and calculating measures of group differences from these aggregated signals."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_2100319 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood ionized calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of ionized calcium in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0400017 a rdfs:Class ;
  rdfs:label "BioSorter500" ;
  rdfs:comment "A BioSorter500 is a flow_cytometer_sorter manufactured by Union Biometrica. It includes analog electronics, 488/514 nm multi-line Argon-ion laser for fluorescence and a light stabilized 670 nm forward scatter laser for extinction and time-of-flight. It has filters and PMTs for 3 fluorescent parameters and photodiodes for scatter, time of flight, and extinction. The flow cell is quartz cuvette. The BioSorterTM 500 is an instrument for analyzing and sorting objects from 100-250 microns in diameter and less than 2mm in length."@en ;
  rdfs:subClassOf obo:OBI_0400099 .

obo:OBI_0001658 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001703 , obo:OBI_0600031 .

obo:OBI_0003009 a rdfs:Class ;
  rdfs:label "ferritin assay" ;
  rdfs:comment "An assay that measures ferritin"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001581 a rdfs:Class ;
  rdfs:label "equilibrium dissociation constant (KD) approximated by EC50" ;
  rdfs:comment "A measurement of an EC50 value under specific assay conditions approximates KD, namely the binding reaction is at an equilibrium,  and the concentration of the receptor must be much less than the KD for the ligand."@en ;
  rdfs:subClassOf obo:OBI_0001536 , obo:OBI_0003143 .

obo:OBI_2100168 a rdfs:Class ;
  rdfs:label "blood gas venous blood carbon dioxide assay" ;
  rdfs:comment "An analyte assay that measures the abundance of carbon dioxide in venous blood as part of a blood gas order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100001 .

obo:PATO_0001341 a rdfs:Class ;
  rdfs:label "a mating type (yeast)" ;
  rdfs:comment "A S. cerevisiae mating type cells that secrete a pheromone that in alpha haploids stimulates processes that lead to mating." ;
  rdfs:subClassOf obo:PATO_0001342 .

obo:IAO_0000579 a rdfs:Class ;
  rdfs:label "centrally registered identifier registry"@en ;
  rdfs:comment "A code set of CRID records, each consisting of a CRID symbol and additional information which was recorded in the code set through an assigning a centrally registered identifier process."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0003908 a rdfs:Class ;
  rdfs:label "mean interspike interval in network spike" ;
  rdfs:comment "A multi-electrode assay that measures the average interval between network spikes, events where multiple electrodes simultaneously detect an action potential."@en ;
  rdfs:subClassOf obo:OBI_0003901 .

obo:OBI_2100147 a rdfs:Class ;
  rdfs:label "venous blood fibrinogen assay" ;
  rdfs:comment "An assay that measures fibrinogen in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003010 , obo:OBI_0003040 .

obo:OBI_0200033 a rdfs:Class ;
  rdfs:label "leave one out cross validation method"@en ;
  rdfs:comment "is a data transformation :  leave-one-out cross-validation (LOOCV) involves using a single observation from the original sample as the validation data, and the remaining observations as the training data. This is repeated such that each observation in the sample is used once as the validation data"@en ;
  rdfs:subClassOf obo:OBI_0000792 .

obo:OBI_0003649 a rdfs:Class ;
  rdfs:label "liquid chromatography-tandem mass spectrometry analysis" ;
  rdfs:subClassOf obo:OBI_0003647 , obo:OBI_0003648 , obo:OBI_0200085 .

obo:UBERON_0001052 a rdfs:Class ;
  rdfs:label "rectum" ;
  rdfs:comment "The terminal portion of the intestinal tube, terminating with the anus." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0000854 a rdfs:Class ;
  rdfs:label "western blot assay" ;
  rdfs:comment "An analyte assay that detects specific peptides in an input material by separating it using gel electrophoresis, transfering the separated molecules to a membrane, and staining them with_ antibodies specific to the analyte molecules."@en ;
  rdfs:subClassOf obo:OBI_0001978 .

obo:UBERON_0000341 a rdfs:Class ;
  rdfs:label "throat" ;
  rdfs:comment "In anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the trachea and prevents inhalation of food or drink. The throat contains various blood vessels, various pharyngeal muscles, the trachea (windpipe) and the esophagus. The hyoid bone and the clavicle are the only bones located in the throat of mammals. It is sometimes considered a synonym for fauces. [WP,unvetted]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

<https://w3id.org/linkml/Any> a rdfs:Class ;
  rdfs:comment "An unconstrained type or object" .

obo:OBI_2100024 a rdfs:Class ;
  rdfs:label "calcium cation assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium cation"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0003835 a rdfs:Class ;
  rdfs:label "neuron interburst interval assay" ;
  rdfs:comment "An electrophysiology assay that measures the elapsed time between consecutive action potential bursts in neurons."@en ;
  rdfs:subClassOf obo:OBI_0001977 , obo:OBI_0002176 .

obo:OBI_0000905 a rdfs:Class ;
  rdfs:label "sequence feature annotation" ;
  rdfs:comment "Information about a sequence region"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0002054 a rdfs:Class ;
  rdfs:label "NMR assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex" ;
  rdfs:comment "A B cell epitope equilibrium dissociation constant (KD) determination assay that uses a nuclear magnetic resonance assay."@en ;
  rdfs:subClassOf obo:OBI_0001708 .

obo:NCBITaxon_3379134 a rdfs:Class ;
  rdfs:label "Pseudomonadati" ;
  rdfs:subClassOf obo:NCBITaxon_2 .

obo:UBERON_0001577 a rdfs:Class ;
  rdfs:label "facial muscle" ;
  rdfs:comment "A muscle innervated by a facial nerve." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0000495 a rdfs:Class ;
  rdfs:label "vacuum degasser" ;
  rdfs:comment "A degassing system used for degassing solvents in liquid chromatography. Dissolved gasses, usually nitrogen and oxygen from the air, tend to be evolved in the mobile phase as the pressure is reduced when the mobile phase leaves the liquid chromatography column and enters the detector. Gasses in the mobile phase in the detector can produce completely unacceptable noise and, thus, must be removed. The dissolved gasses were originally removed under vacuum but, unfortunately, are soon replaced if the solvent is left in contact with air at atmospheric pressure. For this reason degassing is now usually carried out by bubbling helium through the mobile phase reservoirs. Secondly, vacuum is used in the thermionic detector. This consists of a device, very similar in design to the thermionic valve which is attached to a vacuum and a small quantity of the eluent from a gas chromatography column allowed to bleed through it. Helium is used as the carrier gas. The presence of solute vapor causes the thermionic current to fall. This type of detector tends to become contaminated rather readily."@en ;
  rdfs:subClassOf obo:OBI_0000589 .

obo:OBI_2100360 a rdfs:Class ;
  rdfs:label "liver fibrosis (chronic viral hepatitis) venous blood platelet count assay" ;
  rdfs:comment "A cytometry assay that measures the count of platelets in venous blood as part of a liver fibrosis (chronic viral hepatitis) order"@en ;
  rdfs:subClassOf obo:OBI_0003028 , obo:OBI_0003040 .

obo:OBI_0002639 a rdfs:Class ;
  rdfs:label "in vivo assay measuring T cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific T cells based on pathogen burden" ;
  rdfs:comment "An in vivo assay measuring T cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using pathogen burden."@en ;
  rdfs:subClassOf obo:OBI_0001475 , obo:OBI_0003470 .

obo:OBI_0000604 a rdfs:Class ;
  rdfs:label "detector lamp" ;
  rdfs:comment "A lamp used in a chromatography detector that excites sample molecules at certain frequencies / emission wavelengths, e.g. Mercury Vapor Lamp (253.7 nm), Zinc Vapor Lamp (2123.9 nm and 307.6 nm), Cadmium Vapor Lamp (228.8, 326.1,340.3, and 346.6 nm). To obtain monochromatic light an appropriate light filter would be needed."@en ;
  rdfs:subClassOf obo:OBI_0000601 .

obo:OBI_0002640 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific protection from challenge resulting from the adoptive transfer of epitope specific antibodies or B cells based on pathogen burden" ;
  rdfs:comment "An in vivo assay measuring B cell epitope specific protection from pathogen challenge resulting from the adoptive transfer of epitope specific antibodies or B cells using pathogen burden."@en ;
  rdfs:subClassOf obo:OBI_0002051 , obo:OBI_0003475 .

obo:OBI_0001795 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific IP-10 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects IP-10 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001308 , obo:OBI_0600031 .

obo:OBI_0001176 a rdfs:Class ;
  rdfs:label "Individual epitope immunization in vivo" ;
  rdfs:comment "An immunization in which an individual epitope is administered into a host organism."@en ;
  rdfs:subClassOf obo:OBI_1110015 .

obo:OBI_2100218 a rdfs:Class ;
  rdfs:label "estimated venous blood glomerular filtration assay" ;
  rdfs:comment "An assay that measures glomerular filtration in venous blood as part of a estimated order"@en ;
  rdfs:subClassOf obo:OBI_0003040 .

obo:OBI_0001676 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-7 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-7 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001587 .

obo:IAO_0000005 a rdfs:Class ;
  rdfs:label "objective specification"@en ;
  rdfs:comment "A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0000071 a rdfs:Class ;
  rdfs:label "quantitative confidence value"@en ;
  rdfs:comment "A data item which is used to indicate the degree of uncertainty about a measurement."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002436 a rdfs:Class ;
  rdfs:label "RNA interactome capture" ;
  rdfs:comment "An assay that identifies RNA binding proteins by cross-linking RNA and proteins with UV light, then purifying the bound complexes by oligo(dT) capture. Finally, the complexes are analyzed by mass spectrometry."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_1110171 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific interleukin-13 production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects interleukin-13 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001251 , obo:OBI_0600031 .

obo:GO_0032606 a rdfs:Class ;
  rdfs:label "type I interferon production" ;
  rdfs:comment "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_0000862 a rdfs:Class ;
  rdfs:label "nuclear RNA extract" ;
  rdfs:comment "A RNA extract that is the output of an extraction process in which RNA molecules found in the nucleus, including mRNA precursors (pre-mRNA), are extracted."@en ;
  rdfs:subClassOf obo:OBI_0000880 .

obo:OBI_0003915 a rdfs:Class ;
  rdfs:label "ultra high throughput single-cell combinatorial indexing RNA sequencing 3 assay" ;
  rdfs:comment "A single-cell transcription profiling by RNA sequencing assay that involves single cell combinatorial indexing ('sci-') to profile the transcriptomes of single cells or nuclei in an ultra high-throughput manor via changes to the method, as compared to sci-RNA-seq, that include extraction of nuclei directly from fresh tissue, use of hairpin ligation for the third level of indexing, optimization of enxymatic reactions, and use of dilution instead of FACS sorting."@en ;
  rdfs:subClassOf obo:OBI_0002631 .

obo:OBI_2000017 a rdfs:Class ;
  rdfs:label "reticulocyte specimen" ;
  rdfs:comment "A specimen that is derived from some reticulocytes"@en ;
  rdfs:subClassOf obo:OBI_0001468 .

obo:OBI_0600029 a rdfs:Class ;
  rdfs:label "isolation of cell culture supernatant"@en ;
  rdfs:comment "a protocol which results in the separation of supernatant material from a cell culture"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0002137 a rdfs:Class ;
  rdfs:label "RNA Integrity Number value specification"@en ;
  rdfs:comment "A value specification that specifies the value of the RNA Integrity Number as a real value between 1 (most degraded) and 10 (most intact)."@en ;
  rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_0002390 a rdfs:Class ;
  rdfs:label "exposure to second hand smoke" ;
  rdfs:comment "A clinical history in which there has been second hand exposure to tobacco smoking."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000182 a rdfs:Class ;
  rdfs:label "hepatocyte" ;
  rdfs:comment "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:OBI_0001024 a rdfs:Class ;
  rdfs:label "RNASE U2 structure mapping assay" ;
  rdfs:comment "A single-nucleotide-resolution ribonucleic acid structure mapping assay that determines nucleic acid secondary structure at a nucleotide resolution scale using RNAase U2 as reagent and enzymatic probe"@en ;
  rdfs:subClassOf obo:OBI_0001014 .

obo:OBI_0003514 a rdfs:Class ;
  rdfs:label "muscle weakness assessment" ;
  rdfs:comment "A functional assessment of an individual's ability to perform muscle movement to overcome gravity or physical resistence."@en ;
  rdfs:subClassOf obo:OBI_0003501 .

obo:OBI_0001140 a rdfs:Class ;
  rdfs:label "spike-in quality control role"@en ;
  rdfs:comment "a reference substance role that is borne by a material entity with a known amount which is mixed into the evaluant of assays for quality control or data normalization purposes"@en ;
  rdfs:subClassOf obo:OBI_0000025 .

obo:OBI_0000564 a rdfs:Class ;
  rdfs:label "tecmag EAGLE probe" ;
  rdfs:comment "The Eagle is a 4 mm 1H/X solid-state MAS probe with a top spinning speed of 18 kHz. Its simple design is robust, reliable and easy to spin. Configurations are available for 200 to 600 MHz wide bore magnets on Tecmag, Bruker, Chemagnetics, JEOL and Varian spectrometers."@en ;
  rdfs:subClassOf obo:OBI_0000479 .

obo:OBI_0001198 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific interleukin-27 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects interleukin-27 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002917 a rdfs:Class ;
  rdfs:label "knockdown arthropod specimen collection by pyrethrum spray" ;
  rdfs:comment "A knockdown arthropod specimen collection process in which the pesticide is pyrethrum."@en ;
  rdfs:subClassOf obo:OBI_0002918 .

obo:OBI_0001713 a rdfs:Class ;
  rdfs:label "B cell epitope specific opsonization" ;
  rdfs:comment "opsonization resulting from antibody binding to epitope"@en ;
  rdfs:subClassOf obo:GO_0008228 .

obo:OBI_0003791 a rdfs:Class ;
  rdfs:label "bacterial flagellin detection in plasma assay" ;
  rdfs:comment "An analyte assay measuring bacterial flagellin in a plasma sample."@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:OBI_0200000 a rdfs:Class ;
  rdfs:label "data transformation"@en ;
  rdfs:comment "A completely executed planned process that produces output data from input data."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_2100139 a rdfs:Class ;
  rdfs:label "urine creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in urine"@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_2100003 .

obo:OBI_0000865 a rdfs:Class ;
  rdfs:label "96-well neutralization assay" ;
  rdfs:comment "A serum neutralization of viral infectivity assay which is performed in a 96-well plate."@en ;
  rdfs:subClassOf obo:OBI_0000872 .

obo:OBI_2100217 a rdfs:Class ;
  rdfs:label "hepatic panel venous blood human alkaline phosphatase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a hepatic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100017 .

obo:OBI_0200108 a rdfs:Class ;
  rdfs:label "eh transformation"@en ;
  rdfs:comment "An eh transformation is a data transformation obtained by applying the function EH described in what follows to a (one dimensional) real number input. EH(x)=exp(x*d/r)+b*(d/r)*x-1, if x>=0, and EH(x)=-exp(-x*d/r)+b*(d/r)*x+1, otherwise. Here exp denotes an exponential transformation and b, d, r are positive real constants with the objective of normalization."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0000811 a rdfs:Class ;
  rdfs:label "obsolete primary structure of DNA macromolecule" ;
  rdfs:comment "a quality of a DNA molecule that inheres in its bearer due to the order of its DNA nucleotide residues"@en ;
  rdfs:subClassOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteClass> .

obo:OBI_0000791 a rdfs:Class ;
  rdfs:label "multiple testing correction objective" ;
  rdfs:comment "A multiple testing correction objectives is a data transformation objective where the aim is to correct for a set of statistical inferences considered simultaneously"@en ;
  rdfs:subClassOf obo:OBI_0200186 .

obo:IAO_8000008 a rdfs:Class ;
  rdfs:label "analysis subset ontology module"@en ;
  rdfs:comment "An ontology module that is intended for usage in analysis or discovery applications."@en ;
  rdfs:subClassOf obo:IAO_8000006 .

obo:OBI_0001246 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects tumor necrosis factor superfamily cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001400 .

obo:OBI_0003723 a rdfs:Class ;
  rdfs:label "natural killer cell percentage assay" ;
  rdfs:comment "A cytometry assay that measures the percentage of natural killer cells in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:UBERON_0002369 a rdfs:Class ;
  rdfs:label "adrenal gland" ;
  rdfs:comment "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." ;
  rdfs:subClassOf obo:UBERON_0002530 .

obo:OBI_0400048 a rdfs:Class ;
  rdfs:label "Guava EasyCyte Mini" ;
  rdfs:comment "A Guava_EasyCyte_Mini is a flow_cytometer_analyser that includes a single 488 nm laser, and filters and PMTs to collect up to 3 fluorescent parameters. It includes a photodiode forward scatter collector and an optional photodiode for side scatter collection.Guava cytometers use aspiration instead of fluid systems to transport cells within the machine. The mini accepts tubes only for inputting cells or beads. The Guava_EasyCyte_Mini cytometer is a small portable cytometer particularly useful for field measurement."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0000727 a rdfs:Class ;
  rdfs:label "k-nearest neighbors"@en ;
  rdfs:comment "A k-nearest neighbors is a data transformation which achieves a class discovery or partitioning objective, in which an input data object with vector y is assigned to a class label based upon the k closest training data set points to y; where k is the largest value that class label is assigned."@en ;
  rdfs:subClassOf obo:OBI_0200171 , obo:OBI_0200175 .

obo:OBI_0001505 a rdfs:Class ;
  rdfs:label "purification"@en ;
  rdfs:comment "A planned process to separate a material entity into different compositions of which one or more have are purified fractions that contain higher concentration of a desired component, while others contain impurities and are not of interest"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0001107 a rdfs:Class ;
  rdfs:label "tissue embedding station" ;
  rdfs:comment "A device that is used to perform paraffin embedding of tissue specimens."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001322 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific granzyme B release by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects  epitope specific granzyme B release by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001436 , obo:OBI_0600031 .

obo:GO_0032637 a rdfs:Class ;
  rdfs:label "interleukin-8 production" ;
  rdfs:comment "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_1110016 a rdfs:Class ;
  rdfs:label "adaptive immune effector function"@en ;
  rdfs:comment "A function realized as an immune response, which inheres in a T cell, B cell or antibody which derives from or is produced by a cell with prior antigen experience."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0002103 a rdfs:Class ;
  rdfs:label "bio-layer interferometry assay measuring the off rate [koff] of a B cell epitope:antibody complex" ;
  rdfs:comment "A bio-layer interferometry assay that measures the off rate of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001723 , obo:OBI_0002107 .

obo:OBI_0001981 a rdfs:Class ;
  rdfs:label "disease exacerbation in vivo intervention experiment" ;
  rdfs:comment "An in vivo intervention experiment that tests the ability of the intervention to increase the severity of a disease in the host."@en ;
  rdfs:subClassOf obo:OBI_0001980 .

obo:OBI_0001337 a rdfs:Class ;
  rdfs:label "clinical history design" ;
  rdfs:comment "A study design that the organism's clinical history of diagnosis, treatments, e.g. vaccinations, surgery etc. is studied."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_1110023 a rdfs:Class ;
  rdfs:label "immunogen"@en ;
  rdfs:comment "a material entity bearing the immunogen role"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0200045 a rdfs:Class ;
  rdfs:label "single linkage hierarchical clustering"@en ;
  rdfs:comment "A single linkage hierarchical clustering is an agglomerative hierarchical clustering which generates successive clusters based on a distance measure, where the distance between two clusters is calculated as the minimum distance between objects from the first cluster and objects from the second cluster."@en ;
  rdfs:subClassOf obo:OBI_0200154 .

obo:OBI_0001169 a rdfs:Class ;
  rdfs:label "age since birth measurement datum"@en ;
  rdfs:comment "An age measurement datum that is the result of the measurement of the age of an organism since birth, the process of emergence and separation of offspring from the mother."@en ;
  rdfs:subClassOf obo:OBI_0001167 .

obo:OBI_0002406 a rdfs:Class ;
  rdfs:label "delivery form for hormonal replacement therapy" ;
  rdfs:comment "A processed material used for delivery of hormones in hormone replacement therapy."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:GO_0072535 a rdfs:Class ;
  rdfs:label "tumor necrosis factor (ligand) superfamily member 11 production" ;
  rdfs:comment "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0071706 .

obo:OBI_1110182 a rdfs:Class ;
  rdfs:label "epitope specific T cell proliferation"@en ;
  rdfs:comment "A biological process where T cells proliferate resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0042098 .

obo:OBI_2100054 a rdfs:Class ;
  rdfs:label "panel5 venous blood creatinine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of creatinine in venous blood as part of a panel5 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100003 .

obo:OBI_2100099 a rdfs:Class ;
  rdfs:label "CBC with manual differential venous blood band neutrophil count assay" ;
  rdfs:comment "A cytometry assay that measures the count of band neutrophils in venous blood as part of a CBC with manual differential order"@en ;
  rdfs:subClassOf obo:OBI_0003022 , obo:OBI_0003040 .

obo:OBI_0002001 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 2000" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation, with two flow cells and a throughput of up to 55 Gb per day. Built upon sequencing by synthesis technology, the machine is optimized for generation of data for multiple samples in a single run."@en ;
  rdfs:subClassOf obo:OBI_0003683 .

obo:GO_0071609 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 5 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:PATO_0001906 a rdfs:Class ;
  rdfs:label "movement quality" ;
  rdfs:comment "A physical quality inhering in a bearer by virtue of the bearer's participation in movement." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0002744 a rdfs:Class ;
  rdfs:label "molecular label"@en ;
  rdfs:comment "A molecular reagent intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay"@en ;
  rdfs:subClassOf obo:COB_0000013 , obo:OBI_0001879 .

obo:OBI_0001901 a rdfs:Class ;
  rdfs:label "specimen identifier assigned by sequencing facility"@en ;
  rdfs:comment "A specimen identifier which is assigned by a sequencing facility"@en ;
  rdfs:subClassOf obo:OBI_0001616 .

obo:OBI_0001570 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific vascular endothelial growth factor production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects vascular endothelial growth factor production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0001257 a rdfs:Class ;
  rdfs:label "epitope specific interleukin-1 alpha production by T cells" ;
  rdfs:comment "A process of interleukin-1 alpha production by T cells resulting from the recognition of a T cell epitope."@en ;
  rdfs:subClassOf obo:GO_0032610 , obo:OBI_0001193 .

obo:OBI_0003049 a rdfs:Class ;
  rdfs:label "hand-held sweep net" ;
  rdfs:comment "A device that consists of a network of mesh and is designed to capture adult arthropods."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:UBERON_0005921 a rdfs:Class ;
  rdfs:label "middle nasal concha" ;
  rdfs:comment "The medial surface of the labyrinth of ethmoid consists of a thin lamella, which descends from the under surface of the cribriform plate, and ends below in a free, convoluted margin, the middle nasal concha. It is rough, and marked above by numerous grooves, directed nearly vertically downward from the cribriform plate; they lodge branches of the olfactory nerves, which are distributed to the mucous membrane covering the superior nasal concha." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0001512 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific interleukin-17A production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects interleukin-17A production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001296 , obo:OBI_0001773 , obo:OBI_0003115 .

obo:OBI_0100066 a rdfs:Class ;
  rdfs:label "organ section"@en ;
  rdfs:comment "A processed material which derives from an organ and results from a process of dissection or histological sample preparation a portion(formerly an organ section is portion of an organ removed from the context of the organ)"@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:PATO_0001335 a rdfs:Class ;
  rdfs:label "bacterial mating type" ;
  rdfs:comment "A mating type that indicates whether the F plasmid has integrated into the chromosome." ;
  rdfs:subClassOf obo:PATO_0001895 .

obo:OBI_2100067 a rdfs:Class ;
  rdfs:label "venous blood phosphate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of phosphate in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100015 .

obo:OBI_0002770 a rdfs:Class ;
  rdfs:label "partial karyotype information"@en ;
  rdfs:comment "A karyotype information that is about the structural variation of partial genome rather than whole genome."@en ;
  rdfs:subClassOf obo:OBI_0002769 .

obo:OBI_0003313 a rdfs:Class ;
  rdfs:label "genome architecture mapping assay" ;
  rdfs:comment "A DNA sequencing assay designed to analyze 3D chromatin structure without relying on digestion and ligation. The procedure involves cryosectioning samples in random orientation, and then single nuclear profiles are isolated by laser microdissection. Each nuclear profile then undergoes high-throughput sequencing, and subsequent analysis can generate a matrix of inferred proximity between genomic regions."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0001513 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring competitive binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that detects loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001555 .

obo:CHEBI_17996 a rdfs:Class ;
  rdfs:label "chloride" ;
  rdfs:comment "A halide anion formed when chlorine picks up an electron to form an an anion." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0001970 a rdfs:Class ;
  rdfs:label "multiplexed sequencing library"@en ;
  rdfs:comment "a multiplexed library is a material entity which is the output of a library preparation process that uses a ligation step to attach a unique multiplexing sequence identifier to a specific sample, then mixes several such tagged samples prior to the library amplification process proper. A multiplexed library allows the sequencing of several samples in one sequencing run."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0003102 a rdfs:Class ;
  rdfs:label "nanodroplet processing in one pot for trace samples assay" ;
  rdfs:comment "A protein expression profiling assay in which proteomics sample processing is performed in nanoliter volumes. Flow cytometry or laser microdissection is employed to isolate a small population or single cells into a nanoPOTS chip. Then, liquid chromatography mass spectrometry is used to measure the global protein expression."@en ;
  rdfs:subClassOf obo:OBI_0000615 .

obo:OBI_0002097 a rdfs:Class ;
  rdfs:label "assay measuring the dissociation constant [KD] of a T cell epitope:MHC:TCR complex" ;
  rdfs:comment "A T cell epitope binding constant determination assay that measures the dissociation constant KD."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0002059 .

obo:OBI_0001277 a rdfs:Class ;
  rdfs:label "detection of specific nucleic acids with complementary probes assay measuring epitope specific interleukin-2 production by T cells" ;
  rdfs:comment "A detection of specific nucleic acid polymers with complementary probes that detects interleukin-2 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000874 , obo:OBI_0001445 .

obo:OBI_0001483 a rdfs:Class ;
  rdfs:label "cell collecting"@en ;
  rdfs:comment "A planned process that collects cells from culture."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0003182 a rdfs:Class ;
  rdfs:label "total bilirubin concentration assay" ;
  rdfs:comment "A bilirubin IXalpha assay that measures the concentration of total bilirubin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_2100018 .

obo:OBI_0001907 a rdfs:Class ;
  rdfs:label "immortalizing cell line transformation" ;
  rdfs:comment "a genetic transformation of a cell line cell with transgenic constructs intended to confer the capability for indefinite propagation in culture"@en ;
  rdfs:subClassOf obo:OBI_0600043 .

obo:OBI_0002938 a rdfs:Class ;
  rdfs:label "ovitrap" ;
  rdfs:comment "An arthropod trap that consists of a container holding a mesh layer above water and is designed to trap arthropods hatched from eggs dropped over the water by gravid females."@en ;
  rdfs:subClassOf obo:OBI_0002920 .

obo:OBI_0003690 a rdfs:Class ;
  rdfs:label "dry ice bath" ;
  rdfs:comment "A temperature control bath in which a dry ice solvent mixture acts as contact medium at a constant temperatures significantly below 0 degrees Celsius."@en ;
  rdfs:subClassOf obo:OBI_0400120 .

obo:OBI_0000504 a rdfs:Class ;
  rdfs:label "sample injection system" ;
  rdfs:comment "An automated chromatography system that injects the sample into the chromatography columns in order to increase speed and minimize human involvement in the purification process for  better reproducibility."@en ;
  rdfs:subClassOf obo:OBI_0000048 .

obo:OBI_2100013 a rdfs:Class ;
  rdfs:label "leukocyte count assay" ;
  rdfs:comment "A cytometry assay that measures the count of leukocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000738 a rdfs:Class ;
  rdfs:label "restriction enzyme based cloning" ;
  rdfs:comment "restriction enzyme based cloning is a recombinant vector cloning process that has as an input genetic material that was cleaved with restriction enzymes, and a cloning vector that was cleaved with complementary restriction enzymes. It uses ligase to chemically join the input genetic material and the cloning vector to create a recombinant vector."@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_0200153 a rdfs:Class ;
  rdfs:label "number of variables"@en ;
  rdfs:comment "The number of variables is a feature of any function (including polynomial functions) with domain contained in an n-dimensional vector space and is defined as n, the dimension of such space."@en ;
  rdfs:subClassOf obo:OBI_0200140 .

obo:OBI_0000800 a rdfs:Class ;
  rdfs:label "cross linking" ;
  rdfs:comment "A process in which bonds are created that link one polymer to another"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0000964 a rdfs:Class ;
  rdfs:label "in live cell assay" ;
  rdfs:comment "An assay in which a measurement is made by observing entities located in a live cell."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000659 a rdfs:Class ;
  rdfs:label "specimen collection process" ;
  rdfs:comment "A planned process with the objective to obtain a material entity for potential use as an input upon which measurements or observations are performed."@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:GO_0005575 a rdfs:Class ;
  rdfs:label "cellular_component" ;
  rdfs:comment "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0200060 a rdfs:Class ;
  rdfs:label "t cell epitope prediction"@en ;
  rdfs:comment "A T cell epitope prediction takes as input an antigen sequence, and through an analysis of this sequence, produces as output a prediction of the likelihood the biomaterial is a T cell epitope."@en ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_2100244 a rdfs:Class ;
  rdfs:label "chem16 venous blood human alkaline phosphatase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100017 .

obo:OBI_2100027 a rdfs:Class ;
  rdfs:label "segmented neutrophil of bone marrow count assay" ;
  rdfs:comment "A cytometry assay that measures the count of segmented neutrophil of bone marrows"@en ;
  rdfs:subClassOf obo:OBI_0003022 .

obo:OBI_0400097 a rdfs:Class ;
  rdfs:label "Somacount" ;
  rdfs:comment "A Somacount is a flow_cytometer_analyser manufactured by Bently Instruments. It is a specialized tool for counting somatic cells in milk by specifically staining them with Ethidium Bromide and counting the cells that fluoresce. It has one laser, and the filters and a PMT for the single parameter. There are three sizes available, the 150, 300, and 500 with the number indicating the maximum number of cells that can be analysed per hour. The Somacount is an example of a very specific use cytometer; it exclusively counts somatic cells in milk."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:GO_0006260 a rdfs:Class ;
  rdfs:label "DNA replication" ;
  rdfs:comment "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_0000939 a rdfs:Class ;
  rdfs:label "training process" ;
  rdfs:comment "a process that achieves a training objective"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0003607 a rdfs:Class ;
  rdfs:label "disease causation objective"@en ;
  rdfs:comment "An objective specification that is fulfilled by causing a disease in a particular organism."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0003154 a rdfs:Class ;
  rdfs:label "eosinophil percentage assay" ;
  rdfs:comment "An eosinophil assay that measures the percentage of eosinophils in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003023 .

obo:OBI_0001653 a rdfs:Class ;
  rdfs:label "immunoprecipitation assay measuring binding of a B cell epitope:antibody complex" ;
  rdfs:comment "An immunoprecipitation assay that detects the binding of an antigen with an antibody."@en ;
  rdfs:subClassOf obo:OBI_0001700 , obo:OBI_0001703 .

obo:OBI_0003287 a rdfs:Class ;
  rdfs:label "multiplex real time polymerase chain reaction assay" ;
  rdfs:comment "A real time polymerase chain reaction assay in which multiple DNA sequences are amplified in a single cycle."@en ;
  rdfs:subClassOf obo:OBI_0000893 .

obo:OBI_0400037 a rdfs:Class ;
  rdfs:label "FACS Canto" ;
  rdfs:comment "A FACS_Canto is a flow_cytometer_analyser manufactured by Becton Dickinson. It features digital electronics, a solid state 488 nm, and a HeNe 633 nm lasers, and filters and PMTs for collecting up to 6 fluorescent parameters. The FACS_Canto is an analyser usually used in clinical applications."@en ;
  rdfs:subClassOf obo:OBI_0400008 .

obo:OBI_0002711 a rdfs:Class ;
  rdfs:label "WHO cone kit diagnostic assay" ;
  rdfs:comment "A direct insecticide resistance diagnostic assay uses WHO cone kit."@en ;
  rdfs:subClassOf obo:OBI_0002707 .

obo:OBI_0600063 a rdfs:Class ;
  rdfs:label "vector mediated expression"@en ;
  rdfs:comment "vector mediated expression sis the generation of copies of biomaterial by in a cell_culture modified for this purpose by insertion of an expression vector"@en ;
  rdfs:subClassOf obo:OBI_0600064 .

obo:OBI_0002986 a rdfs:Class ;
  rdfs:label "computed tomography imaging assay" ;
  rdfs:comment "An imaging assay that uses a series of X-ray images to produce information about the interior structure and composition of an input material entity."@en ;
  rdfs:subClassOf obo:OBI_0000185 .

obo:OBI_0001353 a rdfs:Class ;
  rdfs:label "cytometric bead array assay measuring epitope specific tumor necrosis factor alpha production by T cells" ;
  rdfs:comment "A cytometric bead array assay that detects tumor necrosis factor alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001368 , obo:OBI_0001416 , obo:OBI_0003115 .

obo:OBI_2100321 a rdfs:Class ;
  rdfs:label "GEM4000 ANLCOOX arterial blood sodium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of sodium in arterial blood as part of a GEM4000 ANLCOOX order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100002 .

obo:OBI_0001575 a rdfs:Class ;
  rdfs:label "assigning gene property based on phenotypic assessment" ;
  rdfs:comment "Interpreting data from assays that evaluate the qualities or dispositions inhering in an organism or organism part and comparing it to data from other organisms that have a defined genetic difference, and assigning a property to the product of the targeted gene as a result."@en ;
  rdfs:subClassOf obo:OBI_0000338 .

obo:OBI_0003503 a rdfs:Class ;
  rdfs:label "tongue atrophy assessment" ;
  rdfs:comment "An observational assessment of the loss of muscle tissue related to tongue movement due to inactivity or disease."@en ;
  rdfs:subClassOf obo:OBI_0003536 .

obo:OBI_0400109 a rdfs:Class ;
  rdfs:label "homogenizer" ;
  rdfs:comment "A homogenizer is an instrument for the homogenization of various types of material, such as tissue, plant, food, soil, and many others."@en ;
  rdfs:subClassOf obo:OBI_0001033 .

obo:OBI_0003219 a rdfs:Class ;
  rdfs:label "bile salt concentration assay" ;
  rdfs:comment "A bile salt assay that measures the concentration of bile salt in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003218 .

obo:OBI_0001472 a rdfs:Class ;
  rdfs:label "specimen with known storage state" ;
  rdfs:comment "A specimen for which it is known whether it has been subjected to storage of a specified type."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0002655 a rdfs:Class ;
  rdfs:label "fine needle aspiration biopsy" ;
  rdfs:comment "A biopsy that uses a thin needle to extract cells."@en ;
  rdfs:subClassOf obo:OBI_0002654 .

obo:OBI_0001780 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific macrophage inflammatory protein-1 alpha production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects macrophage inflammatory protein-1 alpha production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0001333 , obo:OBI_0600031 .

obo:OBI_2100274 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood lactic acid assay" ;
  rdfs:comment "An assay that measures lactic acid in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100042 .

obo:OBI_0002440 a rdfs:Class ;
  rdfs:label "Hi-C assay" ;
  rdfs:comment "A chromosome conformation capture assay that detects genome-wide chromosomal interactions. High-throughput techniques are used to sequence the ligated fragments after cross-linking and cutting with restriction enzymes."@en ;
  rdfs:subClassOf obo:OBI_0002439 .

obo:OBI_0000892 a rdfs:Class ;
  rdfs:label "Southern blot assay" ;
  rdfs:comment "An analyte assay that detects the presence of a specific sequence in a DNA sample, which has been digested by restriction enzymes, resolved by gel electrophoresis, and blotted to a solid support, followed by hybridization of a probe raised against a specific sequence and detected with fluorescence or radioactivity."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:MRO_0000967 a rdfs:Class ;
  rdfs:label "H2-Dd protein complex" ;
  rdfs:subClassOf obo:MRO_0001460 .

obo:OBI_0000631 a rdfs:Class ;
  rdfs:label "Varian MERCURY spectrometer" ;
  rdfs:comment "MERCURYplus spectrometers provide superior control, stability, and performance for high-productivity environments. Surface-mount electronics enable a small footprint without compromising data quality. Modular design allows flexible configuration. Direct digital synthesis, linear amplifiers, and other innovative RF and digital technologies enable push-button operation."@en ;
  rdfs:subClassOf obo:OBI_0000611 .

obo:OBI_2100247 a rdfs:Class ;
  rdfs:label "chem16 venous blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_0001482 a rdfs:Class ;
  rdfs:label "intracellular cytokine staining assay measuring epitope specific transforming growth factor-beta production by T cells" ;
  rdfs:comment "A flow cytometry assay that detects transforming growth factor-beta production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000916 , obo:OBI_0001264 .

obo:OBI_0000679 a rdfs:Class ;
  rdfs:label "average value"@en ;
  rdfs:comment "A  data item that is produced as the output of an averaging data transformation and represents the average value of the input data."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000592 a rdfs:Class ;
  rdfs:label "chromatography detector filter" ;
  rdfs:comment "An optical filter that is used to obtain monochromatic light of a defined wavelength from detector lamps."@en ;
  rdfs:subClassOf obo:OBI_0000601 .

obo:OBI_0002536 a rdfs:Class ;
  rdfs:label "cerebral cortex specimen" ;
  rdfs:comment "A specimen that is derived from cerebral cortex."@en ;
  rdfs:subClassOf obo:OBI_0002516 .

obo:OBI_0003684 a rdfs:Class ;
  rdfs:label "Illumina NextSeq series instrument" ;
  rdfs:comment "A DNA Sequencer manufactured and/or marketed by Illumina and branded with the word NextSeq."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0003824 a rdfs:Class ;
  rdfs:label "neural crest cell migration assay" ;
  rdfs:comment "A cell migration assay that measures migration of a neural crest cell"@en ;
  rdfs:subClassOf obo:OBI_0003820 .

obo:VO_0000001 a rdfs:Class ;
  rdfs:label "vaccine" ;
  rdfs:comment "Material entity that is manufactured to realize the vaccine function." ;
  rdfs:subClassOf obo:COB_0000026 .

obo:OBI_0001102 a rdfs:Class ;
  rdfs:label "electron paramagnetic resonance spectrometer" ;
  rdfs:comment "An spectrophotometer that is used to investigate chemical species that have one or more unpaired electrons, such as organic and inorganic free radicals or inorganic complexes possessing a transition metal ion."@en ;
  rdfs:subClassOf obo:OBI_0400115 .

obo:OBI_2100092 a rdfs:Class ;
  rdfs:label "basic metabolic panel venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood as part of a basic metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0003298 a rdfs:Class ;
  rdfs:label "DNA adenine methyltransferase identification assay" ;
  rdfs:comment "An assay for identifying DNA binding sites for a protein by fusing it to Dam methylase, and expressing it so that bound DNA gets methylated. The methylated DNA can then be isolated and analyzed."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_2100263 a rdfs:Class ;
  rdfs:label "total venous blood cholesterol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of cholesterol in venous blood as part of a total order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100031 .

obo:OBI_0000902 a rdfs:Class ;
  rdfs:label "post mortem specimen" ;
  rdfs:comment "a specimen that was taken from a dead organism"@en ;
  rdfs:subClassOf obo:OBI_0001506 .

obo:OBI_0001411 a rdfs:Class ;
  rdfs:label "cell type comparison design" ;
  rdfs:comment "A study design that compares cells of different type, for example different cell lines."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0001429 a rdfs:Class ;
  rdfs:label "cell differentiation design" ;
  rdfs:comment "A study design that assays events associated with cell development or differentiation."@en ;
  rdfs:subClassOf obo:OBI_0500000 .

obo:OBI_0002162 a rdfs:Class ;
  rdfs:label "footprinting assay" ;
  rdfs:comment "An assay that measures ligand binding and conformational changes by the solvent accessibility of the backbone, bases, or side-chain structures of macromolecules through their sensitivity to chemical or enzymatic cleavage or modification reactions."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000526 a rdfs:Class ;
  rdfs:label "preparative autosampler" ;
  rdfs:comment "For preparative LC with injection of sample volumes ranging from L to mL ranges."@en ;
  rdfs:subClassOf obo:OBI_0000494 .

obo:COB_0001300 a rdfs:Class ;
  rdfs:label "device"@en ;
  rdfs:comment "A processed material entity which is designed to be capable of a process."@en ;
  rdfs:subClassOf obo:COB_0000026 .

obo:GAZ_00000448 a rdfs:Class ;
  rdfs:label "geographic location" ;
  rdfs:comment "A reference to a place on the Earth, by its name or by its geographical location." ;
  rdfs:subClassOf obo:BFO_0000029 .

obo:IAO_0000179 a rdfs:Class ;
  rdfs:label "histogram"@en ;
  rdfs:comment """A histogram is a report graph which is a statistical description of a
distribution in terms of occurrence frequencies of different event classes."""@en ;
  rdfs:subClassOf obo:IAO_0000038 .

obo:OBI_0000134 a rdfs:Class ;
  rdfs:label "hardware testing objective"@en ;
  rdfs:comment "Hardware_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different hardware, e.g. scanner."@en ;
  rdfs:subClassOf obo:OBI_0000208 .

obo:OBI_0003369 a rdfs:Class ;
  rdfs:label "assay kit" ;
  rdfs:comment "A device that consists of reagents and devices that enable the performance of a specific type of assay, which could, in addition, require specific instruments not included in the kit."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0001687 a rdfs:Class ;
  rdfs:label "contact representative role"@en ;
  rdfs:comment "A role inhering in a person who represents an institution, organization, or service provider and realized when communication is directed at them about the entity they represent."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:PATO_0001708 a rdfs:Class ;
  rdfs:label "1-D extent" ;
  rdfs:comment "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." ;
  rdfs:subClassOf obo:PATO_0000117 .

obo:CHEBI_37972 a rdfs:Class ;
  rdfs:label "phosphorus-32 atom" ;
  rdfs:comment "The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days." ;
  rdfs:subClassOf obo:COB_0000011 , obo:OBI_0001879 .

obo:OBI_0200119 a rdfs:Class ;
  rdfs:label "median calculation"@en ;
  rdfs:comment "A median calculation is a  descriptive statistics calculation in which the midpoint of the data set (the 0.5 quantile) is calculated.  First, the observations are sorted in increasing order.  For an odd number of observations, the median is the middle value of the sorted data.  For an even number of observations, the median is the average of the two middle values."@en ;
  rdfs:subClassOf obo:OBI_0200181 , obo:OBI_0200184 .

obo:OBI_0002491 a rdfs:Class ;
  rdfs:label "medication dose value specification" ;
  rdfs:comment "A scalar value specification that specifies the value of the quantity of a material entity administered to an organism as a treatment"@en ;
  rdfs:subClassOf obo:OBI_0001931 .

obo:OBI_0003414 a rdfs:Class ;
  rdfs:label "administering substance in vivo to reduce or prevent disease" ;
  rdfs:comment "An administration of substance in vivo with the intention to reduce the symptoms of or prevent development of a disease in the organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_2100402 a rdfs:Class ;
  rdfs:label "pooled clone sequencing assay" ;
  rdfs:comment "A DNA sequencing assay in which the DNA input is derived from pooled clones (for example BACs and Fosmids) is sequenced."@en ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0003803 a rdfs:Class ;
  rdfs:label "urine histological assay" ;
  rdfs:comment "A histological assay with urine sediment as evaluant."@en ;
  rdfs:subClassOf obo:OBI_0003043 , obo:OBI_0600020 .

obo:OBI_0000029 a rdfs:Class ;
  rdfs:label "centrifuge pellet role"@en ;
  rdfs:comment "pellet role is a role which inheres in a material entity and is realized by a material separation process using gravitational force generated by a centrifuge in which the material bearing the pellet role is the heavier or heaviest component of the output material.."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_2100266 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003232 , obo:OBI_2100023 .

obo:OBI_0003531 a rdfs:Class ;
  rdfs:label "upper limb coordination assessment" ;
  rdfs:comment "A limb coordination assessment designed to assess an individual's ability to coordinate upper limb movement."@en ;
  rdfs:subClassOf obo:OBI_0003530 .

obo:OBI_0001416 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific tumor necrosis factor alpha production by T cells" ;
  rdfs:comment "An assay of epitope specific tumor necrosis factor alpha production by T cells that detects tumor necrosis factor production."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001400 .

obo:OBI_2100281 a rdfs:Class ;
  rdfs:label "ABL90 panel arterial blood bicarbonate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of bicarbonate in arterial blood as part of a ABL90 panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100043 .

obo:OBI_0001143 a rdfs:Class ;
  rdfs:label "labeled nucleic acid extract" ;
  rdfs:comment "a labeled specimen that is the output of a labeling process and has grain labeled nucleic acid for detection of the nucleic acid in future experiments."@en ;
  rdfs:subClassOf obo:OBI_0000924 .

obo:NCBITaxon_40674 a rdfs:Class ;
  rdfs:label "Mammalia" ;
  rdfs:subClassOf obo:NCBITaxon_32524 .

obo:OBI_0000597 a rdfs:Class ;
  rdfs:label "Bruker NMR magnet" ;
  rdfs:comment "An NMR magnet that is manufactured by Bruker."@en ;
  rdfs:subClassOf obo:OBI_0000517 .

obo:OBI_0000668 a rdfs:Class ;
  rdfs:label "error correction data transformation"@en ;
  rdfs:comment "An error correction data transformation is a data transformation that has the objective of error correction, where the aim is to remove (correct for) erroneous contributions from the input to the data transformation."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_2100343 a rdfs:Class ;
  rdfs:label "liver function venous blood human alkaline phosphatase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human alkaline phosphatase in venous blood as part of a liver function order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100017 .

obo:OBI_2100224 a rdfs:Class ;
  rdfs:label "chem11 venous blood phosphate assay" ;
  rdfs:comment "An analyte assay that measures the abundance of phosphate in venous blood as part of a chem11 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100015 .

obo:OBI_0500002 a rdfs:Class ;
  rdfs:label "repeated measure design" ;
  rdfs:comment "a study design which use the same individuals and exposure them to a set of conditions. The effect of order and practice can be confounding factor in such designs"@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:OBI_2100035 a rdfs:Class ;
  rdfs:label "thyroxine assay" ;
  rdfs:comment "An analyte assay that measures the abundance of thyroxine"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0002524 a rdfs:Class ;
  rdfs:label "urinary bladder specimen" ;
  rdfs:comment "A specimen that is derived from urinary bladder."@en ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0003069 a rdfs:Class ;
  rdfs:label "sequencing protocol" ;
  rdfs:comment "A protocol that, when concretized, is realized in an assay that uses chemical or biological means to infer the sequence of a biomaterial."@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:OBI_2100389 a rdfs:Class ;
  rdfs:label "free/total venous blood PSA assay" ;
  rdfs:comment "An analyte assay that measures the abundance of PSA in venous blood as part of a free/total order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100034 .

obo:OBI_0600067 a rdfs:Class ;
  rdfs:label "specific labeling"@en ;
  rdfs:comment "a labeling in which the labeling reagent used  has a specificity to bind only certain components of the input material"@en ;
  rdfs:subClassOf obo:OBI_0600038 .

obo:UBERON_0007109 a rdfs:Class ;
  rdfs:label "meconium" ;
  rdfs:comment "A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth." ;
  rdfs:subClassOf obo:UBERON_0001988 .

obo:OBI_0003571 a rdfs:Class ;
  rdfs:label "intraocular administration" ;
  rdfs:comment "An administration of a substance to the eye of an organism."@en ;
  rdfs:subClassOf obo:OBI_0600007 .

obo:OBI_0001865 a rdfs:Class ;
  rdfs:label "assay array" ;
  rdfs:comment "A device made to be used in an analyte assay for immobilization of substances that bind the analyte at regular spatial positions on a surface."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0600030 a rdfs:Class ;
  rdfs:label "experimental disease induction"@en ;
  rdfs:comment "a protocol application to induce a specific disease in an organism"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_2100393 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid macrophage count assay" ;
  rdfs:comment "A cytometry assay that measures the count of macrophages in cerebrospinal fluid"@en ;
  rdfs:subClassOf obo:OBI_0003027 , obo:OBI_0003232 .

obo:OBI_0001568 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring half maximal inhibitory concentration [IC50] to determine competitive binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures half maximal inhibitory concentration (IC50) to detect the loss of binding of a known reference ligand to purified-MHC due to competition by the ligand under investigation."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001992 .

obo:OBI_0003716 a rdfs:Class ;
  rdfs:label "blood pressure assay" ;
  rdfs:comment "A vital sign assay that determines the blood pressure (force of blood against the artery walls) of an organism."@en ;
  rdfs:subClassOf obo:OBI_0003715 .

obo:OBI_0200022 a rdfs:Class ;
  rdfs:label "variance stabilizing transformation"@en ;
  rdfs:comment "A variance stabilizing transformation is a data transformation, described in PMID 12169536, whose input is a matrix [y_ik] and whose output is a matrix obtained by applying formula (6) in this paper. One of the goals is to obtain an output matrix whose rows have equal variances. The method relies on various assumptions described in the paper."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0000537 a rdfs:Class ;
  rdfs:label "copy number variation profiling assay" ;
  rdfs:comment "An assay that determines lost or amplified genomic regions of DNA by comparing genomic DNA originating from tissues from the same or different individuals using specific techniques such as CGH, array CGH, SNP genotyping"@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0001400 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific tumor necrosis factor superfamily cytokine production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects tumor necrosis factor superfamily cytokine production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0002800 a rdfs:Class ;
  rdfs:label "personal protective clothing item" ;
  rdfs:comment "A personal protective device which consists of a garment that serves in place of or in addition to regular body clothing."@en ;
  rdfs:subClassOf obo:OBI_0002786 .

obo:OBI_0000620 a rdfs:Class ;
  rdfs:label "Bruker micro imaging probe" ;
  rdfs:comment "For medical, biological and material sciences research, avance imaging systems provide optimal object handling and performance with a variety of samples types. Two classes of imaging probes are available: in vivo probes for handling and sustaining live objects such as animals and plants, and conventional imaging probes for materials samples."@en ;
  rdfs:subClassOf obo:OBI_0000561 .

obo:OBI_0200018 a rdfs:Class ;
  rdfs:label "loess group transformation one-channel"@en ;
  rdfs:comment "A loess group transformation one-channel is a loess group transformation in the special case where the input is the result of an MA transformation applied to intensities from two related one-channel assays."@en ;
  rdfs:subClassOf obo:OBI_0200024 .

obo:OBI_0000969 a rdfs:Class ;
  rdfs:label "dose specification" ;
  rdfs:comment "a directive information entity that describes the dose that will be administered to a target"@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0400074 a rdfs:Class ;
  rdfs:label "mixed argon-krypton gas laser" ;
  rdfs:comment "A mixed argon krypton gas laser is an ion laser in which the lasing medium is a mixture of argon and krypton. A mixed argon-krypton laser can by used to irradiate cells in a flow cytometer."@en ;
  rdfs:subClassOf obo:OBI_0400060 .

obo:OBI_0001396 a rdfs:Class ;
  rdfs:label "stimulus or stress design" ;
  rdfs:comment "A study design in which the response of an organism(s) to the stress or stimulus is studied, e.g. osmotic stress, heat shock, radiation exposure, behavioral treatment etc."@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:UBERON_0001638 a rdfs:Class ;
  rdfs:label "vein" ;
  rdfs:comment "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." ;
  rdfs:subClassOf obo:UBERON_0001981 .

obo:NCBITaxon_10239 a rdfs:Class ;
  rdfs:label "Viruses" ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_2100158 a rdfs:Class ;
  rdfs:label "comprehensive metabolic panel venous blood protein assay" ;
  rdfs:comment "An analyte assay that measures the abundance of protein in venous blood as part of a comprehensive metabolic panel order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100023 .

obo:PATO_0000165 a rdfs:Class ;
  rdfs:label "time" ;
  rdfs:comment "A quality in which events occur in sequence." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:GO_0002390 a rdfs:Class ;
  rdfs:subClassOf obo:GO_0001816 .

obo:FOODON_03309997 a rdfs:Class ;
  rdfs:label "food material for animals"@en ;
  rdfs:comment "Food product for animal covers foods intended for consumption by domesticated animals."@en ;
  rdfs:subClassOf obo:FOODON_00002147 .

obo:IAO_0000027 a rdfs:Class ;
  rdfs:label "data entity"@en ;
  rdfs:comment "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:GO_0001172 a rdfs:Class ;
  rdfs:label "RNA-templated transcription" ;
  rdfs:comment "The synthesis of an RNA transcript from an RNA template." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:NCBITaxon_10358 a rdfs:Class ;
  rdfs:label "Cytomegalovirus" ;
  rdfs:subClassOf obo:NCBITaxon_3044472 .

obo:OBI_0003521 a rdfs:Class ;
  rdfs:label "stance feet apart assessment, with eyes closed" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with their eyes closed."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0500007 a rdfs:Class ;
  rdfs:label "randomized complete block design" ;
  rdfs:comment "A randomized complete block design is_a study design which assigns randomly treatments to block. The number of units per block equals the number of treatment so each block receives each treatment exactly once (hence the qualifier 'complete'). The design was originally devised from field trials used in agronomy and agriculture. The analysis assumes that there is no interaction between block and treatment. The method was then used in other settings So The randomised complete block design is a design in which the subjects are matched according to a variable which the experimenter wishes to control. The subjects are put into groups (blocks) of the same size as the number of treatments. The members of each block are then randomly assigned to different treatment groups."@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:OBI_0002734 a rdfs:Class ;
  rdfs:label "DNA based blood meal finger printing assay" ;
  rdfs:comment "A DNA fingerprinting assay that uses DNA extracted from blood meal fed organism, such as insect."@en ;
  rdfs:subClassOf obo:OBI_0002694 , obo:OBI_0002732 .

obo:OBI_0003026 a rdfs:Class ;
  rdfs:label "reticulocyte assay" ;
  rdfs:comment "A cytometry assay that measures the abundance and/or characteristics of reticulocytes"@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0000581 a rdfs:Class ;
  rdfs:label "y-column connector" ;
  rdfs:comment "A column connector that connects one column on one side with two columns at the other side, hence building a Y shaped structure."@en ;
  rdfs:subClassOf obo:OBI_0000478 .

obo:OBI_0200093 a rdfs:Class ;
  rdfs:label "polynomial transformation"@en ;
  rdfs:comment "A polynomial transformation is a data transformation that is obtained through a polynomial, where a polynomial is a mathematical expression involving a sum of powers in one or more variables multiplied by coefficients (e.g. see http://mathworld.wolfram.com/Polynomial.html). The number of variables and the degree are properties of a polynomial. The degree of a polynomial is the highest power of its terms, where the terms of a polynomial are the individual summands with the coefficients omitted."@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0000484 a rdfs:Class ;
  rdfs:label "NMR sample holder" ;
  rdfs:comment "An NMR sample holder is the part of an NMR instrument, which carries the NMR probe,sample tube and the nmr sample."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_0000975 a rdfs:Class ;
  rdfs:label "cell-cell binding detection by flow cytometry assay" ;
  rdfs:comment "A binding assay which uses a flow cytometer to detect pairs of cells that are bound to each other by staining them with different fluorescent labels."@en ;
  rdfs:subClassOf obo:OBI_0001977 .

obo:OBI_0002397 a rdfs:Class ;
  rdfs:label "gynecologic surgery history" ;
  rdfs:comment "A clinical history in which a woman has had gynecologic surgery in the past."@en ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002480 a rdfs:Class ;
  rdfs:label "sequencing library input quantity measurement datum"@en ;
  rdfs:comment "A scalar measurement datum that indicates the amount of sequencing library used as input for a sequencer."@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:OBI_0000928 a rdfs:Class ;
  rdfs:label "material combination function" ;
  rdfs:comment "A material separation function is a function that decreases the resolution between two or more material entities."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0002029 a rdfs:Class ;
  rdfs:label "serial analysis of gene expression assay" ;
  rdfs:comment "A transcription profiling by RNA sequencing assay that quantifies RNA through creating short signature tags of the messages and ligating them into a larger molecule that is then sequenced."@en ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0000634 a rdfs:Class ;
  rdfs:label "DNA methylation profiling assay" ;
  rdfs:comment "An assay that measures the state of methylation of DNA molecules using genomic DNA collected from a material entity using a range of techniques and instrument such as DNA sequencers and often relying on treatment with bisulfites to ensure cytosine conversion."@en ;
  rdfs:subClassOf obo:OBI_0002020 .

obo:OBI_0001624 a rdfs:Class ;
  rdfs:label "organism species detection assay" ;
  rdfs:comment "An organism detection assay that identifies the organism species in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003498 .

obo:OBI_0003481 a rdfs:Class ;
  rdfs:label "cow-baited arthropod trap" ;
  rdfs:comment "A resting arthropod trap that consists of a tent inside which an adult cow is tethered to the ground, in order to attract arthropods and collect those that rest on the interior walls of the tent."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:UBERON_0004648 a rdfs:Class ;
  rdfs:label "esophagus muscularis mucosa" ;
  rdfs:comment "A muscularis mucosa that is part of a esophagus." ;
  rdfs:subClassOf obo:UBERON_0002385 .

obo:OBI_0002184 a rdfs:Class ;
  rdfs:label "cut open oocyte voltage clamp assay" ;
  rdfs:comment "The cut-open oocyte Vaseline gap (COVG) voltage-clamp technique is designed to solve weaknesses in the two elextrode voltage clamp by maximizing the benefits of the Xenopus oocyte expression system by improving on clamp speed, signal-to-noise ratio, and ability to effectively perfuse the oocyte. In this way, it was possible to combine the most popular transient expression system, and the associated benefits of molecular cloning and site-directed mutagenesis, with the superior voltage-clamp properties of cut-open cell techniques."@en ;
  rdfs:subClassOf obo:OBI_0002182 .

obo:OBI_0001117 a rdfs:Class ;
  rdfs:label "DNA extraction/purification instrument" ;
  rdfs:comment "A device that is used to isolate and collect DNA for subsequent molecular analysis."@en ;
  rdfs:subClassOf obo:OBI_0001114 .

obo:OBI_0001959 a rdfs:Class ;
  rdfs:label "multiplexed nucleotide library sequencing"@en ;
  rdfs:comment "A planned process which consists in running a set of samples as a pool on a sequencing instrument, while retaining the ability to associate individual results to each of the individual input samples through the use of a ligated oligonucleotide (the \"multiplex identifier sequence\"). This oligonucleotide is  introduced during the sequence library preparation, and is unique to and specific for all library fragments derived from each sample in a sample pool."@en ;
  rdfs:subClassOf obo:COB_0000110 .

obo:OBI_0002181 a rdfs:Class ;
  rdfs:label "outside-out patch clamp assay" ;
  rdfs:comment "A patch-clamp assay where a patch of the membrane is attached to the patch pipette. In this configuration, the external surface of the cell membrane is exposed as the outside of the membrane patch relative to the patch electrode. An outside-out patch starts with a gigaohm seal in a whole-cell recording configuration. The electrode is slowly withdrawn from the cell, until a fragment of membrane bulges away from the cell, which detaches and reforms as a convex membrane on the end of the electrode, with the original external surface of the membrane facing outward from the electrode. This provides the experimenter with access to the extracellular surface of the membrane via the bath and can manipulate the environment at the extracellular surface of single ion channels."@en ;
  rdfs:subClassOf obo:OBI_0002177 .

obo:GO_0071610 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 1 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0003523 a rdfs:Class ;
  rdfs:label "stance feet together assessment, with eyes closed" ;
  rdfs:comment "A limits of stability assessment designed to assess an individual's ability to maintain a stable stance with feet together and eyes closed."@en ;
  rdfs:subClassOf obo:OBI_0003518 .

obo:OBI_0003882 a rdfs:Class ;
  rdfs:label "super-resolution microscopy assay" ;
  rdfs:comment "A type of light microscopy assay where the images are taken with a resolution higher than the diffraction limit."@en ;
  rdfs:subClassOf obo:OBI_0002119 .

obo:MRO_0001759 a rdfs:Class ;
  rdfs:label "mouse MHC class I protein complex with H2-b haplotype" ;
  rdfs:subClassOf obo:MRO_0001460 .

obo:NCBITaxon_2 a rdfs:Class ;
  rdfs:label "Bacteria" ;
  rdfs:subClassOf obo:COB_0000022 .

obo:OBI_0001586 a rdfs:Class ;
  rdfs:label "radioactivity detection assay measuring half life to determine direct binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A radioactivity detection assay that measures half life to detect the direct binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001491 , obo:OBI_0001990 .

obo:OBI_0002076 a rdfs:Class ;
  rdfs:label "collection of specimens"@en ;
  rdfs:comment "A material entity that has two or more specimens as its parts."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0001358 a rdfs:Class ;
  rdfs:label "post-transcriptional modification design" ;
  rdfs:comment "A study design in which a modification of the transcriptome, proteome (not genome) is made, for example RNAi, antibody targeting."@en ;
  rdfs:subClassOf obo:OBI_0000115 .

obo:OBI_0003780 a rdfs:Class ;
  rdfs:label "electrochemiluminescence assay" ;
  rdfs:comment "A chemiluminescent assay that detects a substance by measuring the release of light triggered by an electrochemical reaction."@en ;
  rdfs:subClassOf obo:OBI_0003779 .

obo:UBERON_0001255 a rdfs:Class ;
  rdfs:label "urinary bladder" ;
  rdfs:comment "Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." ;
  rdfs:subClassOf obo:UBERON_0000062 .

obo:OBI_0003627 a rdfs:Class ;
  rdfs:label "antibody purification of mouse MHC class I protein complex" ;
  rdfs:comment "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex, while others contain impurities and are not of interest."@en ;
  rdfs:subClassOf obo:OBI_0003616 .

obo:OBI_0002789 a rdfs:Class ;
  rdfs:label "medical mask" ;
  rdfs:comment "A face mask manufactured according to a recognized medical equipment standard."@en ;
  rdfs:subClassOf obo:OBI_0002787 .

obo:OBI_0000164 a rdfs:Class ;
  rdfs:label "clonal cDNA library"@en ;
  rdfs:comment """Mixed population of cDNAs (complementaryDNA) made from mRNA from a defined source, usually a specific cell type. This term should be associated only to nucleic acid interactors not to their proteins product. For instance in 2h screening use living cells (MI:0349) as sample process.

ALT DEF (PRS):: a cDNA library is a collection of host cells, typically E.Coli cells but not exclusively. modified by transfer of plasmid DNA molecule used as vector containing a fragment or totality of cDNA molecule (the insert) .  cDNA library may have an array of role and applications."""@en ;
  rdfs:subClassOf obo:OBI_0000731 .

obo:OBI_0001642 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific antibody-dependent cellular cytotoxicity" ;
  rdfs:comment "A B cell epitope specific activation of additional immune response assay that detects antibody-dependent cellular cytotoxicity in vitro."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0001704 .

obo:OBI_0000409 a rdfs:Class ;
  rdfs:label "nucleic acid template role"@en ;
  rdfs:comment "a reference substance role which inheres in nucleic acid material entity and is realized in the process of using the nucleic acid bearing the template role as a reference during synthesis of a reverse copy."@en ;
  rdfs:subClassOf obo:OBI_0000025 .

obo:OBI_0302846 a rdfs:Class ;
  rdfs:label "randomized group participant role"@en ;
  rdfs:comment "a role that borne by an organism and realized by some group randomization process"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_1110120 a rdfs:Class ;
  rdfs:label "assay antigen role"@en ;
  rdfs:comment "An antigen role that is realized as part of an assay, where immune recognition of the material with the assay antigen role is being detected as part of the assay."@en ;
  rdfs:subClassOf obo:OBI_0000237 .

obo:OBI_2100061 a rdfs:Class ;
  rdfs:label "venous blood chloride assay" ;
  rdfs:comment "An analyte assay that measures the abundance of chloride in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100010 .

obo:OBI_0002155 a rdfs:Class ;
  rdfs:label "venereal disease research laboratory test" ;
  rdfs:comment "An analyte assay that is meant to detect general antibodies that react with substances that are produced by cellular damage caused by Treponema pallidum indicating a syphilis infection. VDRL tests require a microscope and can be done on cerebrospinal fluid as well as blood."@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_2100299 a rdfs:Class ;
  rdfs:label "bone profile venous blood calcium assay" ;
  rdfs:comment "An analyte assay that measures the abundance of calcium in venous blood as part of a bone profile order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100024 .

obo:OBI_0200011 a rdfs:Class ;
  rdfs:label "logical transformation"@en ;
  rdfs:comment "A logical transformation is a data transformation that, for each (one dimensional) real number input x, outputs an approximation (found, e.g. with the Newton's method) to a solution y of the equation S(y)-x=0, where S denotes an s transformation."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:CHEBI_16526 a rdfs:Class ;
  rdfs:label "carbon dioxide" ;
  rdfs:comment "A one-carbon compound with formula CO<small><sub>2</sub></small> in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:OBI_0002558 a rdfs:Class ;
  rdfs:label "use of medication inclusion criterion"@en ;
  rdfs:comment "An inclusion criterion that defines and states a a set of medications, which, if used by an entity, makes that entity suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0000876 a rdfs:Class ;
  rdfs:label "cytoplasmic RNA extract" ;
  rdfs:comment "A RNA extract that is the output of a RNA extraction process in which RNA molecules found in the cytoplasm are extracted."@en ;
  rdfs:subClassOf obo:OBI_0000880 .

obo:OBI_0001899 a rdfs:Class ;
  rdfs:label "target capture specification"@en ;
  rdfs:comment "A plan specification which specifies how the material enrichment procedure will influence the scale, or type of material that will be assayed in the specimen."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:PATO_0001025 a rdfs:Class ;
  rdfs:label "pressure" ;
  rdfs:comment "A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0002055 a rdfs:Class ;
  rdfs:label "assay measuring biological activity resulting from T cell epitope:MHC:TCR binding" ;
  rdfs:comment "A T cell epitope recognition assay that measures the immune response process resulting from the binding of a T cell receptor to epitope or the recongition of the epitope."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_0003128 .

obo:OBI_0001128 a rdfs:Class ;
  rdfs:label "micropipette" ;
  rdfs:comment "A microinjection device that is used to measure very small volumes of liquids."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0302906 a rdfs:Class ;
  rdfs:label "DNA Subtraction"@en ;
  rdfs:comment "a material separation process by which repetitive genomic DNA is removed during the construction of cDNA library."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0003080 a rdfs:Class ;
  rdfs:label "organismal body temperature measurement assay" ;
  rdfs:comment "An assay that detects body temperature of an organism."@en ;
  rdfs:subClassOf obo:OBI_0002140 .

obo:CHEBI_37973 a rdfs:Class ;
  rdfs:label "phosphorus-33 atom" ;
  rdfs:comment "The radioactive isotope of phosphorus with relative atomic mass 32.971725, half-life of 25.34 days and nuclear spin <small><sup>1</small></sup>/<small><sub>2</sub></small>." ;
  rdfs:subClassOf obo:COB_0000011 , obo:OBI_0001879 .

obo:OBI_2100121 a rdfs:Class ;
  rdfs:label "24 hour total urine volume assay" ;
  rdfs:comment "An assay that measures volume in urine as part of a 24 hour total order"@en ;
  rdfs:subClassOf obo:OBI_0003043 .

obo:OBI_0001616 a rdfs:Class ;
  rdfs:label "specimen identifier"@en ;
  rdfs:comment "A CRID symbol denotes a specimen and used to distinguish one specimen from another in an investigation."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_2100032 a rdfs:Class ;
  rdfs:label "low-density lipoprotein cholesterol assay" ;
  rdfs:comment "An analyte assay that measures the abundance of low-density lipoprotein cholesterol"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:OBI_0001590 a rdfs:Class ;
  rdfs:label "fluorescence detection assay measuring direct binding of a purified-MHC:ligand complex" ;
  rdfs:comment "A fluorescence detection assay that detects direct binding of a purified-MHC molecule with a ligand."@en ;
  rdfs:subClassOf obo:OBI_0001499 , obo:OBI_0001555 .

obo:OBI_0002733 a rdfs:Class ;
  rdfs:label "blood meal by counter current immunoelectrophoresis assay" ;
  rdfs:comment "A blood meal assay that uses a counter current immunoelectrophoresis technique."@en ;
  rdfs:subClassOf obo:OBI_0002732 .

obo:CHEBI_35780 a rdfs:Class ;
  rdfs:label "phosphate ion" ;
  rdfs:comment "A phosphorus oxoanion that is the conjugate base of phosphoric acid." ;
  rdfs:subClassOf obo:COB_0000013 .

obo:NCBITaxon_32524 a rdfs:Class ;
  rdfs:label "Amniota" ;
  rdfs:subClassOf obo:NCBITaxon_32523 .

obo:PATO_0001374 a rdfs:Class ;
  rdfs:label "ploidy" ;
  rdfs:comment "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." ;
  rdfs:subClassOf obo:PATO_0001396 .

obo:OGMS_0000090 a rdfs:Class ;
  rdfs:label "treatment" ;
  rdfs:comment "A planned process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate a disorder, the signs and symptoms of a disorder, or a pathological process"@en ;
  rdfs:subClassOf obo:COB_0000035 .

obo:OBI_0002901 a rdfs:Class ;
  rdfs:label "visible light source" ;
  rdfs:comment "A light source that provides visible light for use in a distant area using a delivery system."@en ;
  rdfs:subClassOf obo:OBI_0400065 .

obo:OBI_0001776 a rdfs:Class ;
  rdfs:label "assay measuring epitope specific chemokine (C-X-C motif) ligand 12 production by T cells" ;
  rdfs:comment "A T cell epitope specific cytokine production assay that detects chemokine (C-X-C motif) ligand 12 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000070 , obo:OBI_1110129 .

obo:OBI_0003031 a rdfs:Class ;
  rdfs:label "fluorogenic PCR assay" ;
  rdfs:comment "A polymerase chain reaction assay that uses target specific probes labeled with fluorogenic chromophores."@en ;
  rdfs:subClassOf obo:OBI_0002692 .

obo:OBI_0003351 a rdfs:Class ;
  rdfs:label "T2 weighted SE magnetic resonance image data set" ;
  rdfs:comment "A type of T2-weighted image in which the acquisition is performed using a 2D spin-echo technique"@en ;
  rdfs:subClassOf obo:OBI_0003348 .

obo:OBI_0000097 a rdfs:Class ;
  rdfs:label "participant under investigation role"@en ;
  rdfs:comment "A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0001064 a rdfs:Class ;
  rdfs:label "automatic tissue processor" ;
  rdfs:comment "A device for processing histological tissue having a tissue carrier basket suspended from a turntable overlying a plurality of beakers suspended from a carrier plate. The turntable is raised, indexed, and lowered by a suitable driving mechanism to move the tissue basket sequentially through the beakers. Timers can each be programmed to control the movement of the turntable to provide various different cycles for processing the tissue. Some of the beakers are received in individual thermal baths to heat and control the temperature of the substances received in the beakers for treating the tissue."@en ;
  rdfs:subClassOf obo:COB_0001300 .

obo:OBI_1110034 a rdfs:Class ;
  rdfs:label "antigen"@en ;
  rdfs:comment "A material entity that has the antigen role."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0000062 a rdfs:Class ;
  rdfs:label "organ" ;
  rdfs:comment "Anatomical structure that performs a specific function or group of functions [WP]." ;
  rdfs:subClassOf obo:UBERON_0000061 .

obo:OBI_0001858 a rdfs:Class ;
  rdfs:label "cross-linking immunoprecipitation high-throughput sequencing assay" ;
  rdfs:comment "An analyte assay that employs UV-crosslinking between RNA and a protein, followed by immunoprecipitation with antibodies for the protein, fragmentation, and high-throughput screening for RNA sequences that interact with a particular RNA-binding protein."@en ;
  rdfs:subClassOf obo:OBI_0000443 , obo:OBI_0600047 .

obo:GO_0032613 a rdfs:Class ;
  rdfs:label "interleukin-10 production" ;
  rdfs:comment "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0001816 .

obo:OBI_2100378 a rdfs:Class ;
  rdfs:label "GEM4 arterial blood oxygen assay" ;
  rdfs:comment "An analyte assay that measures the abundance of oxygen in arterial blood as part of a GEM4 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100036 .

obo:GO_0097389 a rdfs:Class ;
  rdfs:label "chemokine (C-C motif) ligand 21 production" ;
  rdfs:comment "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." ;
  rdfs:subClassOf obo:GO_0032602 .

obo:OBI_0001344 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific monocyte chemotactic protein-1 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects monocyte chemotactic protein-1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001465 .

obo:OBI_0003705 a rdfs:Class ;
  rdfs:label "study arm design"@en ;
  rdfs:comment "A plan specification that is part of a study design, executed as part of an investigation, and realized by assigning participants under investigation to a study design."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0200098 a rdfs:Class ;
  rdfs:label "soft independent modeling of class analogy analysis"@en ;
  rdfs:comment "Soft independent modeling by class analogy (SIMCA) is a descriptive statistics method for supervised classification of data. The method requires a training data set consisting of samples (or objects) with a set of attributes and their class membership. The term soft refers to the fact the classifier can identify samples as belonging to multiple classes and not necessarily producing a classification of samples into non-overlapping classes."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0001315 a rdfs:Class ;
  rdfs:label "ELISA measuring epitope specific chemokine (C-C motif) ligand 1 production by T cells" ;
  rdfs:comment "An enzyme-linked immunosorbent assay that detects chemokine (C-C motif) ligand 1 production by T cells."@en ;
  rdfs:subClassOf obo:OBI_0000661 , obo:OBI_0001276 .

obo:OBI_0400060 a rdfs:Class ;
  rdfs:label "ion laser" ;
  rdfs:comment "An ion laser is a gas laser which uses an ionized gas as its lasing medium."@en ;
  rdfs:subClassOf obo:OBI_0400047 .

obo:OBI_0001631 a rdfs:Class ;
  rdfs:label "electron microscopy imaging assay" ;
  rdfs:comment "An imaging assay in which an electrons are used to probe the density, shape and composition of an input material which are detected in an electron microscope and utilized to produce an image of the material."@en ;
  rdfs:subClassOf obo:OBI_0000185 , obo:OBI_0002119 .

obo:OBI_0002428 a rdfs:Class ;
  rdfs:label "BMI range inclusion criterion" ;
  rdfs:comment "An inclusion criterion that defines and states a Body Mass Index range, which if met, makes an individual suitable for a given task or participation in a given process."@en ;
  rdfs:subClassOf obo:OBI_0500027 .

obo:OBI_0000913 a rdfs:Class ;
  rdfs:label "promoter activity detection by reporter gene assay" ;
  rdfs:comment "An assay in which the activity of a promoter in a cell is monitored by using a reporter gene that was inserted in a genomic location under control of the promoter and whose expression can be easily detected based on qualities or functions of the gene."@en ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:IAO_0000310 a rdfs:Class ;
  rdfs:label "document"@en ;
  rdfs:comment "A collection of information content entities intended to be understood together as a whole"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_2000010 a rdfs:Class ;
  rdfs:label "chorionic villus specimen" ;
  rdfs:comment "A specimen that is derived from some chorionic villus"@en ;
  rdfs:subClassOf obo:OBI_0002513 .

obo:HP_0012824 a rdfs:Class ;
  rdfs:label "Severity" ;
  rdfs:comment "The intensity or degree of a manifestation." ;
  rdfs:subClassOf obo:COB_0000502 .

obo:OBI_2100072 a rdfs:Class ;
  rdfs:label "venous blood glucose assay" ;
  rdfs:comment "An analyte assay that measures the abundance of glucose in venous blood"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100020 .

obo:COB_0000035 a rdfs:Class ;
  rdfs:label "completely executed planned process"@en ;
  rdfs:subClassOf obo:COB_0000082 .

obo:OBI_0003193 a rdfs:Class ;
  rdfs:label "adiponectin concentration assay" ;
  rdfs:comment "An adiponectin assay that measures the concentration of adiponectin in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0003192 .

obo:GO_0042447 a rdfs:Class ;
  rdfs:label "hormone catabolic process" ;
  rdfs:comment "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." ;
  rdfs:subClassOf obo:GO_0009987 .

obo:OBI_0000586 a rdfs:Class ;
  rdfs:label "plunger column" ;
  rdfs:comment "A plunger column is a chromatography column with adjustable heigth control. By means of an adjustable endpiece (plunger) the user can adjust the column length without disturbing the packed bed. Plunger columns can equalize volume changes and thus avoids dead volumes within the column."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0000056 a rdfs:Class ;
  rdfs:label "notified body role"@en ;
  rdfs:comment "Notified body is regulator of consumables and medical devices charged by the Competent Authority with verifying compliance of medical devices (not drugs) with the applicable Essential Requirements stated in the Medical Device Directive"@en ;
  rdfs:subClassOf obo:OBI_0000273 .

obo:OBI_0000086 a rdfs:Class ;
  rdfs:label "reagent role"@en ;
  rdfs:comment "A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer."@en ;
  rdfs:subClassOf obo:OBI_0003610 .

obo:OBI_2100235 a rdfs:Class ;
  rdfs:label "chem16 venous blood human aspartate aminotransferase assay" ;
  rdfs:comment "An analyte assay that measures the abundance of human aspartate aminotransferase in venous blood as part of a chem16 order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100019 .

obo:OBI_0002152 a rdfs:Class ;
  rdfs:label "EBV IgG antibody assay" ;
  rdfs:comment "An antigen specific antibodies assay that is meant to detect immunoglobulin G (IgG) antibodies that bind to Epstein-Barr virus (EBV) antigens."@en ;
  rdfs:subClassOf obo:OBI_0002145 .

obo:OBI_0000175 a rdfs:Class ;
  rdfs:label "p-value"@en ;
  rdfs:comment "A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone."@en ;
  rdfs:subClassOf obo:OBI_0000071 .

obo:OBI_0002080 a rdfs:Class ;
  rdfs:label "human specimen set"@en ;
  rdfs:comment "A specimen set that is collected from one person during a time period which for the purpose of the study can be considered to be taken at the same sampling time."@en ;
  rdfs:subClassOf obo:OBI_0002079 .

obo:GO_0030097 a rdfs:Class ;
  rdfs:label "hemopoiesis" ;
  rdfs:comment "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." ;
  rdfs:subClassOf obo:GO_0008150 .

obo:OBI_2100382 a rdfs:Class ;
  rdfs:label "liver fibrosis (NAFLD) venous blood platelet count assay" ;
  rdfs:comment "A cytometry assay that measures the count of platelets in venous blood as part of a liver fibrosis (NAFLD) order"@en ;
  rdfs:subClassOf obo:OBI_0003028 , obo:OBI_0003040 .

obo:OBI_0003091 a rdfs:Class ;
  rdfs:label "multiplexed fluorescent antibody imaging assay" ;
  rdfs:comment "An imaging assay in which multiple cycles consisting of fluorescent labeling, imaging, and fluorophor deactivation are used to detect multiple proteins and their locations in a given sample of tissues or cells."@en ;
  rdfs:subClassOf obo:OBI_0000185 .

obo:OBI_0000403 a rdfs:Class ;
  rdfs:label "sort function"@en ;
  rdfs:comment "A sort function is a function to distinguish material components based on some associated physical quality or entity and to partition the separate components into distinct fractions according to a defined order."@en ;
  rdfs:subClassOf obo:OBI_0000372 .

obo:OBI_0003143 a rdfs:Class ;
  rdfs:label "EC50 binding datum" ;
  rdfs:comment "A quantitative binding datum that is expressed as a half-maximal effective concentration (EC50)."@en ;
  rdfs:subClassOf obo:OBI_0001180 , obo:OBI_0003142 .

obo:OBI_0002651 a rdfs:Class ;
  rdfs:label "image guided biopsy" ;
  rdfs:comment "A biopsy which uses an imaging procedure to guide a needle biopsy."@en ;
  rdfs:subClassOf obo:OBI_0002654 .

obo:OBI_1110168 a rdfs:Class ;
  rdfs:label "ELISPOT assay measuring epitope specific tumor necrosis factor alpha production by T cells" ;
  rdfs:comment "An enzyme-linked immunospot assay that detects tumor necrosis factor alpha production by T cells"@en ;
  rdfs:subClassOf obo:OBI_0001272 , obo:OBI_0001416 , obo:OBI_0600031 .

obo:OBI_0000048 a rdfs:Class ;
  rdfs:label "chromatography device" ;
  rdfs:comment "A device that facilitates the separation of mixtures. The function of a chromatography device involves passing a mixture dissolved in a \"mobile phase\" through a stationary phase, which separates the analyte to be measured from other molecules in the mixture and allows it to be isolated."@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0000932 , obo:OBI_0002089 .

obo:OBI_2100021 a rdfs:Class ;
  rdfs:label "magnesium cation assay" ;
  rdfs:comment "An analyte assay that measures the abundance of magnesium cation"@en ;
  rdfs:subClassOf obo:OBI_0000443 .

obo:PATO_0001895 a rdfs:Class ;
  rdfs:label "mating type" ;
  rdfs:comment "A biological sex quality inhering in an individual or a population that undergo sexual reproduction." ;
  rdfs:subClassOf obo:PATO_0000047 .

obo:OBI_0200007 a rdfs:Class ;
  rdfs:label "box-cox transformation"@en ;
  rdfs:comment "A box-cox transformation is a data transformation according to the methods of Box and Cox as described in the article Box, G. E. P. and Cox, D.R. (1964) An analysis of transformations. Journal of Royal Statistical Society, Series B, vol. 26, pp. 211-246."@en ;
  rdfs:subClassOf obo:OBI_0200169 .

obo:OBI_0003394 a rdfs:Class ;
  rdfs:label "Affymetrix Mouse Gene 2.1 ST Array" ;
  rdfs:comment "A DNA microarray manufactured by Affymetrix, which is a whole-transcript array that includes probes to measure both messenger (mRNA) and long intergenic non-coding RNA transcripts (lincRNA).To supplement the lincRNA data contained in RefSeq, we used sequence and transcript data from lncRNA db."@en ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:OBI_0001304 a rdfs:Class ;
  rdfs:label "RNAi profiling by array assay" ;
  rdfs:comment "An assay in which double stranded RNA is synthesized with a sequence complementary to a gene(s) of interest and introduced into a cell or organism, where it is recognized as exogenous genetic material and activates the RNAi pathway resulting in knockdown of the transcripts and providing a means to study downstream changes in gene expression."@en ;
  rdfs:subClassOf obo:OBI_0001985 .

obo:OBI_0002129 a rdfs:Class ;
  rdfs:label "Illumina HiSeq X Ten" ;
  rdfs:comment "A DNA sequencer that consists of a set of 10 HiSeq X Sequencing Systems."@en ;
  rdfs:subClassOf obo:OBI_0003683 .

obo:OBI_0001225 a rdfs:Class ;
  rdfs:label "genetic population background information"@en ;
  rdfs:comment "a genetic characteristics information which is a part of genotype information that identifies the population of organisms"@en ;
  rdfs:subClassOf obo:OBI_0001404 .

obo:OBI_0400115 a rdfs:Class ;
  rdfs:label "spectrophotometer" ;
  rdfs:comment "A spectrophotometer is an instrument that measures the intensity of light as a function of the color, or more specifically, the wavelength of light, transmitted by a substance."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0000843 a rdfs:Class ;
  rdfs:label "Sysmex CA-6000 Coagulation Analyzer" ;
  rdfs:comment "The Sysmex CA-6000 automated coagulation analyzer is a random access instrument that is capable of performing 20 clot-based and chromogenic assays"@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_1110045 a rdfs:Class ;
  rdfs:label "disposition to be bound by an adaptive immune receptor"@en ;
  rdfs:comment "Is the disposition borne by a material entity that is realized in a process of being bound by a adaptive immune receptor."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_2100354 a rdfs:Class ;
  rdfs:label "hemoglobin and hematocrit venous blood hemoglobin assay" ;
  rdfs:comment "An analyte assay that measures the abundance of hemoglobin in venous blood as part of a hemoglobin and hematocrit order"@en ;
  rdfs:subClassOf obo:OBI_0003040 , obo:OBI_2100014 .

obo:OBI_0002636 a rdfs:Class ;
  rdfs:label "in vivo assay measuring B cell epitope specific disease reduction resulting from adoptive transfer of epitope specific antibodies or B cells" ;
  rdfs:comment "An efficacy of B cell epitope intervention experiment that detects a decrease in disease after adoptive transfer of epitope specific antibodies or B cells."@en ;
  rdfs:subClassOf obo:OBI_0001190 , obo:OBI_0001697 , obo:OBI_0002677 .

obo:OBI_0000873 a rdfs:Class ;
  rdfs:label "pre-mortem specimen" ;
  rdfs:comment "a specimen that was taken from a live organism"@en ;
  rdfs:subClassOf obo:OBI_0001506 .

obo:BFO_0000062 a rdf:Property ;
  rdfs:label "preceded by"@en ;
  rdfs:comment "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000063 a rdf:Property ;
  rdfs:label "precedes"@en ;
  rdfs:comment "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:COB_0000016 a rdf:Property ;
  rdfs:label "executed by"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:COB_0000081 a rdf:Property ;
  rdfs:label "intended to realize"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:COB_0000084 a rdf:Property ;
  rdfs:label "has plan"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:COB_0000085 a rdf:Property ;
  rdfs:label "intended plan process type"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:COB_0000511 a rdf:Property ;
  rdfs:label "has quantity"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:COB_0000803 a rdf:Property ;
  rdfs:label "has inchi string"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0000111 a rdf:Property ;
  rdfs:label "editor preferred label" ;
  rdfs:comment "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000112 a rdf:Property ;
  rdfs:label "example of usage"@en ;
  rdfs:comment "A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold."@en ;
  rdfs:range xsd:string .

obo:IAO_0000113 a rdf:Property ;
  rdfs:label "in branch"@en ;
  rdfs:comment "An annotation property indicating which module the terms belong to. This is currently experimental and not implemented yet."@en ;
  rdfs:range xsd:string .

obo:IAO_0000114 a rdf:Property ;
  rdfs:label "has curation status"@en ;
  rdfs:range xsd:string .

obo:IAO_0000115 a rdf:Property ;
  rdfs:label "textual definition" ;
  rdfs:comment "The official definition." ;
  rdfs:range xsd:string .

obo:IAO_0000116 a rdf:Property ;
  rdfs:label "editor note"@en ;
  rdfs:comment "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
  rdfs:range xsd:string .

obo:IAO_0000117 a rdf:Property ;
  rdfs:label "term editor"@en ;
  rdfs:comment "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
  rdfs:range xsd:string .

obo:IAO_0000118 a rdf:Property ;
  rdfs:label "alternative label"@en ;
  rdfs:comment "A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like."@en ;
  rdfs:range xsd:string .

obo:IAO_0000119 a rdf:Property ;
  rdfs:label "definition source"@en ;
  rdfs:comment "Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
  rdfs:range xsd:string .

obo:IAO_0000231 a rdf:Property ;
  rdfs:label "has obsolescence reason"@en ;
  rdfs:comment "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en ;
  rdfs:range xsd:string .

obo:IAO_0000232 a rdf:Property ;
  rdfs:label "curator note"@en ;
  rdfs:comment "An administrative note of use for a curator but of no use for a user"@en ;
  rdfs:range xsd:string .

obo:IAO_0000233 a rdf:Property ;
  rdfs:label "term tracker item"@en ;
  rdfs:comment "A URL for a request or discussion of an ontology term."@en ;
  rdfs:range xsd:anyURI .

obo:IAO_0000234 a rdf:Property ;
  rdfs:label "ontology term requester"@en ;
  rdfs:comment "The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition."@en ;
  rdfs:range xsd:string .

obo:IAO_0000235 a rdf:Property ;
  rdfs:label "denoted by"@en ;
  rdfs:comment "inverse of the relation 'denotes'"@en ;
  rdfs:range obo:IAO_0000030 .

obo:IAO_0000407 a rdf:Property ;
  rdfs:label "has coordinate unit label"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0000411 a rdf:Property ;
  rdfs:label "is denotator type"@en ;
  rdfs:comment "Relates an class defined in an ontology, to the type of it's denotator"@en ;
  rdfs:range xsd:string .

obo:IAO_0000412 a rdf:Property ;
  rdfs:label "imported from"@en ;
  rdfs:comment "For external terms/classes, the ontology from which the term was imported"@en ;
  rdfs:range xsd:string .

obo:IAO_0000424 a rdf:Property ;
  rdfs:label "expand expression to"@en ;
  rdfs:comment "A macro expansion tag applied to an object property (or possibly a data property)  which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en ;
  rdfs:range xsd:string .

obo:IAO_0000425 a rdf:Property ;
  rdfs:label "expand assertion to"@en ;
  rdfs:comment "A macro expansion tag applied to an annotation property which can be expanded into a more detailed axiom."@en ;
  rdfs:range xsd:string .

obo:IAO_0000426 a rdf:Property ;
  rdfs:label "first order logic expression"@en ;
  rdfs:range xsd:string .

obo:IAO_0000427 a rdf:Property ;
  rdfs:label "antisymmetric property"@en ;
  rdfs:comment "Use boolean value xsd:true to indicate that the property is an antisymmetric property"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:OMO_0001001 .

obo:IAO_0000589 a rdf:Property ;
  rdfs:label "OBO foundry unique label"@en ;
  rdfs:comment "An alternative name for a class or property which is unique across the OBO Foundry."@en ;
  rdfs:range xsd:string .

obo:IAO_0000596 a rdf:Property ;
  rdfs:label "has ID digit count"@en ;
  rdfs:comment "Relates an ontology used to record id policy to the number of digits in the URI. The URI is: the 'has ID prefix\" annotation property value concatenated with an integer in the id range (left padded with \"0\"s to make this many digits)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000597 a rdf:Property ;
  rdfs:label "has ID range allocated to"@en ;
  rdfs:comment "Relates a datatype that encodes a range of integers to the name of the person or organization who can use those ids constructed in that range to define new terms"@en ;
  rdfs:range xsd:string .

obo:IAO_0000598 a rdf:Property ;
  rdfs:label "has ID policy for"@en ;
  rdfs:comment "Relating an ontology used to record id policy to the ontology namespace whose policy it manages"@en ;
  rdfs:range xsd:string .

obo:IAO_0000599 a rdf:Property ;
  rdfs:label "has ID prefix"@en ;
  rdfs:comment "Relates an ontology used to record id policy to a prefix concatenated with an integer in the id range (left padded with \"0\"s to make this many digits) to construct an ID for a term being created."@en ;
  rdfs:range xsd:string .

obo:IAO_0000600 a rdf:Property ;
  rdfs:label "elucidation"@en ;
  rdfs:range xsd:string .

obo:IAO_0000601 a rdf:Property ;
  rdfs:label "has associated axiom(nl)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000602 a rdf:Property ;
  rdfs:label "has associated axiom(fol)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000603 a rdf:Property ;
  rdfs:label "is allocated id range"@en ;
  rdfs:comment "Relates an ontology IRI to an (inclusive) range of IRIs in an OBO name space. The range is give as, e.g. \"IAO_0020000-IAO_0020999\""@en ;
  rdfs:range xsd:string .

obo:IAO_0000700 a rdf:Property ;
  rdfs:label "has ontology root term"@en ;
  rdfs:comment "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."@en ;
  rdfs:range xsd:string .

obo:IAO_0006011 a rdf:Property ;
  rdfs:label "may be identical to"@en ;
  rdfs:comment "A annotation relationship between two terms in an ontology that may refer to the same (natural) type but where more evidence is required before terms are merged."@en ;
  rdfs:range xsd:string .

obo:IAO_0006012 a rdf:Property ;
  rdfs:label "scheduled for obsoletion on or after"@en ;
  rdfs:comment "Used when the class or object is scheduled for obsoletion/deprecation on or after a particular date."@en ;
  rdfs:range xsd:dateTime .

obo:IAO_0010000 a rdf:Property ;
  rdfs:label "has axiom label"@en ;
  rdfs:range xsd:string .

obo:IAO_0100001 a rdf:Property ;
  rdfs:label "term replaced by"@en ;
  rdfs:comment "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en ;
  rdfs:range xsd:string .

obo:OBI_0000294 a rdf:Property ;
  rdfs:label "obsolete_is_concretization_of"@en ;
  rdfs:comment "Is a relationship between a generically dependent continuant and a specifically dependent continuant. A generically dependent continuant may inhere in more than one entity. It does so by virtue of the fact that there is, for each entity that it inheres, a specifically dependent *concretization* of the generically dependent continuant that is specifically dependent. For instance, consider a story, which is an information artifact that inheres in some number of books. Each book bears some quality that carries the story. The relation between this quality and the generically dependent continuant is that the former is the concretization of the latter."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000295 a rdf:Property ;
  rdfs:label "is specified input of"@en ;
  rdfs:comment "A relation between a completely executed planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of." ;
  rdfs:range obo:COB_0000035 ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:OBI_0000297 a rdf:Property ;
  rdfs:label "obsolete_is_concretized_as"@en ;
  rdfs:comment "Is a relationship between a specifically dependent continuant and a generically dependent continuant. A generically dependent continuant may inhere in more than one entity. It does so by virtue of the fact that there is, for each entity that it inheres, a specifically dependent *concretization* of the generically dependent continuant that is specifically dependent. For instance, consider a story, which is an information artifact that inheres in some number of books. Each book bears some quality that carries the story. The relation between this quality and the generically dependent continuant is that the former is the concretization of the latter."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000298 a rdf:Property ;
  rdfs:label "obsolete_has_quality"@en ;
  rdfs:comment """A relation between an entity and a quality. For types: E has_quality Q iff: 
for any eEt, exists qQt such that q inheres_in e at t. 
For instances: e has_quality q at t iff q inheres_in e at t and q instance-of Quality [GOC:cjm]"""@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000300 a rdf:Property ;
  rdfs:label "obsolete_is_realized_by"@en ;
  rdfs:comment "Relation between a realizable and a process. Reciprocal relation of realizes [GOC:cjm]"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000301 a rdf:Property ;
  rdfs:label "obsoleted_has_specified_output_information"@en ;
  rdfs:comment "A relation between a participant in a process, that produces a data set . The process is the realization of a concretization of a realizable information entity (objective specification or plan specification). In general, not all data present at the end of the process are specified_data."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000306 a rdf:Property ;
  rdfs:label "obsolete_has_function"@en ;
  rdfs:comment "Relation between an independent continuant and a function."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000307 a rdf:Property ;
  rdfs:label "obsoleted_is_reagent_in"@en ;
  rdfs:comment "Relationship between a substance and a protocol application in which it participates, where the substance has a ReagentRole"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000308 a rdf:Property ;
  rdfs:label "obsolete_realizes"@en ;
  rdfs:comment """Relation between a process and a function, where the unfolding of the 
process requires the execution of the function. Class level: P realizes F iff: 
given any p that instantiates P, there exists some f, t such that f instantiates
 F at t and p *realizes* f. Here, *realizes* is the primitive 
instance level relation [GOC:cjm]"""@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000309 a rdf:Property ;
  rdfs:label "obsoleted_utilizes_reagent"@en ;
  rdfs:comment "Relationship between a protocol application and a substance that has role reagent that participates in the protocol application"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000311 a rdf:Property ;
  rdfs:label "obsoleted_is_device_for"@en ;
  rdfs:comment "Relationship between a device and a protocol application in which it  participates"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000313 a rdf:Property ;
  rdfs:label "obsoleted_utilizes_device"@en ;
  rdfs:comment "Relationship between protocol application and an intrument in which it  participates"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000314 a rdf:Property ;
  rdfs:label "is_proxy_for"@en ;
  rdfs:comment "A relation between continuant instances c1 and c2 where within an experiment/ protocol application,  measurement of c1 is used to determine what a measurement of c2 would be."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000315 a rdf:Property ;
  rdfs:label "obsoleted_has_specified_input_information"@en ;
  rdfs:comment "A relation between a process and a participant in that process, that consumes a data set . The process is the realization of a concretization of a directive information entity (objective specification or plan specification). In general, not all data present at the beginning of the process are specified_data."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000316 a rdf:Property ;
  rdfs:label "obsolete_has_role"@en ;
  rdfs:comment "A relation between a continuant C and a role R. The reciprocal relation of role_of."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000365 a rdf:Property ;
  rdfs:label "obsolete_results_from" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000459 a rdf:Property ;
  rdfs:label "obsoleted_is_specified_information_output_of" ;
  rdfs:comment "A relation between a data set and the process in which it participates and was produced.  Inverse of outputs_specified_data relation."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000644 a rdf:Property ;
  rdfs:label "obsoleted_is_specified_information_intput_of" ;
  rdfs:comment "Is the inverse relation of has_specfied_input_information"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_0000645 a rdf:Property ;
  rdfs:label "is grain of"@en ;
  rdfs:comment "A relation between granular parts and the whole of which they are a part. Granular parts have indeterminate number such that removing one granular part does not necessarily damage or diminish the whole."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:OBI_0001847 a rdf:Property ;
  rdfs:label "ISA alternative term"@en ;
  rdfs:comment "An alternative term used by the ISA tools project (http://isa-tools.org)."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000118 .

obo:OBI_0001886 a rdf:Property ;
  rdfs:label "NIAID GSCID-BRC alternative term"@en ;
  rdfs:comment "An alternative term used by the National Institute of Allergy and Infectious Diseases (NIAID) Genomic Sequencing Centers for Infectious Diseases (GSCID) and Bioinformatics Resource Centers (BRC)."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000118 .

obo:OBI_0002815 a rdf:Property ;
  rdfs:label "has representation"@en ;
  rdfs:comment "'has representation' is a data property that attaches between an information content entity and a value that contains linguistically or computationally coded text."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0003385 a rdf:Property ;
  rdfs:label "has assay target context" ;
  rdfs:comment "A relation between  the target entity of an assay and a material entity, where the material entity is the environment in which the target entity of an assay is measured, such as a live mouse, cell culture, test tube, etc."@en ;
  rdfs:range obo:BFO_0000040 .

obo:OBI_1110112 a rdf:Property ;
  rdfs:label "obsolete_is_described_by" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> .

obo:OBI_9991118 a rdf:Property ;
  rdfs:label "IEDB alternative term" ;
  rdfs:comment "An alternative term used by the IEDB."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000118 .

obo:OBI_9991119 a rdf:Property ;
  rdfs:label "FGED alternative term" ;
  rdfs:comment "An alternative term used by the Functional Genomics Data (FGED) Society."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000118 .

obo:OMO_0001001 a rdf:Property ;
  rdfs:label "logical characteristic of object property" ;
  rdfs:comment "This is an annotation used on an object property to indicate a logical characterstic beyond what is possible in OWL." ;
  rdfs:range xsd:string .

obo:OMO_0002000 a rdf:Property ;
  rdfs:label "defined by construct" ;
  rdfs:comment "Links an annotation property to a SPARQL CONSTRUCT query which is meant to provide semantics for a shortcut relation." ;
  rdfs:range xsd:string .

obo:OMO_0002001 a rdf:Property ;
  rdfs:label "preferred label for community" ;
  rdfs:comment "A provenance property that denotes a synonym to be the preferred one for a specific community." ;
  rdfs:range xsd:string .

obo:OMO_0003000 a rdf:Property ;
  rdfs:label "abbreviation" ;
  rdfs:comment "A synonym type for describing abbreviations or initialisms" ;
  rdfs:range xsd:string .

obo:OMO_0003001 a rdf:Property ;
  rdfs:label "ambiguous synonym" ;
  rdfs:comment "A synonym type for describing ambiguous synonyms" ;
  rdfs:range xsd:string .

obo:OMO_0003002 a rdf:Property ;
  rdfs:label "dubious synonym" ;
  rdfs:comment "A synonym type for describing dubious synonyms" ;
  rdfs:range xsd:string .

obo:OMO_0003003 a rdf:Property ;
  rdfs:label "layperson synonym" ;
  rdfs:comment "A synonym type for describing layperson or colloquial synonyms" ;
  rdfs:range xsd:string .

obo:OMO_0003004 a rdf:Property ;
  rdfs:label "plural form" ;
  rdfs:comment "A synonym type for describing pluralization synonyms" ;
  rdfs:range xsd:string .

obo:OMO_0003005 a rdf:Property ;
  rdfs:label "UK spelling synonym" ;
  rdfs:comment "A synonym type for describing UK spelling variants" ;
  rdfs:range xsd:string .

obo:OMO_0003006 a rdf:Property ;
  rdfs:label "misspelling" ;
  rdfs:comment "A synonym type for common misspellings" ;
  rdfs:range xsd:string .

obo:OMO_0003007 a rdf:Property ;
  rdfs:label "misnomer" ;
  rdfs:comment "A synonym type for misnomers, i.e., a synonym that is not technically correct but is commonly used anyway" ;
  rdfs:range xsd:string .

obo:OMO_0003008 a rdf:Property ;
  rdfs:label "previous name" ;
  rdfs:comment "A synonym type for names that have been used as primary labels in the past." ;
  rdfs:range xsd:string .

obo:OMO_0003009 a rdf:Property ;
  rdfs:label "legal name" ;
  rdfs:comment "A synonym type for the legal entity name" ;
  rdfs:range xsd:string .

obo:OMO_0003010 a rdf:Property ;
  rdfs:label "International Nonproprietary Name" ;
  rdfs:comment "The International Nonproprietary Name (INN) is a standardize name for a pharmaceutical drug or active ingredient issued by the World Health Organization (WHO) meant to address the issues with country- or language-specific brand names. These are issued in several languages, including English, Latin, French, Russian, Spanish, Arabic, and Chinese." ;
  rdfs:range xsd:string .

obo:OMO_0003011 a rdf:Property ;
  rdfs:label "latin term" ;
  rdfs:comment "A synonym type for describing Latin term synonyms." ;
  rdfs:range xsd:string .

obo:OMO_0003012 a rdf:Property ;
  rdfs:label "acronym" ;
  rdfs:comment "A synonym type for describing abbreviations that are a part of the full name's words, such as initialisms or alphabetisms." ;
  rdfs:range xsd:string .

obo:OMO_0003014 a rdf:Property ;
  rdfs:label "has ontology hierarchical property" ;
  rdfs:comment "Relates an ontology to predicates/properties that should be used by user interfaces to render the hierarchical structure of the ontology. Typically, this is rdfs:subClassOf, but in ontologies that are partonomies, this might also include BFO:0000050 (part of). Tools like OLS can use predicates annotated with this property for rendering the ontology class hierarchy. There can be more than one hierarchical property. In the absence of any, it should be assumed that it is rdfs:subClassOf." ;
  rdfs:range xsd:string .

obo:OMO_0004000 a rdf:Property ;
  rdfs:label "has symbol" ;
  rdfs:comment "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity." ;
  rdfs:range xsd:string .

obo:RO_0000058 a rdf:Property ;
  rdfs:label "is concretized as"@en ;
  rdfs:comment "A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000080 a rdf:Property ;
  rdfs:label "quality of"@en ;
  rdfs:comment "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000091 a rdf:Property ;
  rdfs:label "has disposition"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000092 a rdf:Property ;
  rdfs:label "disposition of"@en ;
  rdfs:comment "inverse of has disposition" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001015 a rdf:Property ;
  rdfs:label "location of"@en ;
  rdfs:comment "a relation between two independent continuants, the location and the target, in which the target is entirely within the location"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001025 a rdf:Property ;
  rdfs:label "located in"@en ;
  rdfs:comment "a relation between two independent continuants, the target and the location, in which the target is entirely within the location"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002090 a rdf:Property ;
  rdfs:label "immediately precedes"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002180 a rdf:Property ;
  rdfs:label "has component"@en ;
  rdfs:comment "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002219 a rdf:Property ;
  rdfs:label "surrounded by"@en ;
  rdfs:comment "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002220 a rdf:Property ;
  rdfs:label "adjacent to" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002221 a rdf:Property ;
  rdfs:label "surrounds"@en ;
  rdfs:comment "inverse of surrounded by" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002222 a rdf:Property ;
  rdfs:label "temporally related to"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002223 a rdf:Property ;
  rdfs:label "starts"@en ;
  rdfs:comment "inverse of starts with" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002234 a rdf:Property ;
  rdfs:label "has output"@en ;
  rdfs:comment "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002333 a rdf:Property ;
  rdfs:label "enabled by"@en ;
  rdfs:comment "inverse of enables" ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://www.geneontology.org/formats/oboInOwl#ObsoleteProperty> a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://www.w3.org/2002/07/owl#real> a rdfs:Datatype .

obo:OBI_0002270 a rdfs:Class ;
  rdfs:label "pathologic lymph node stage for colon and rectum according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002271 a obo:OBI_0002270 ;
  rdfs:label "pN0 (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating no regional lymph node metastsis."@en .

obo:OBI_0002272 a obo:OBI_0002270 ;
  rdfs:label "pN1 (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 1-3 regional lymph nodes."@en .

obo:OBI_0002273 a obo:OBI_0002270 ;
  rdfs:label "pN1a (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 1 regional lymph node."@en .

obo:OBI_0002274 a obo:OBI_0002270 ;
  rdfs:label "pN1b (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 2-3 regional lymph nodes."@en .

obo:OBI_0002275 a obo:OBI_0002270 ;
  rdfs:label "pN1c (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating tumor deposit(s), i.e., satellites in the subserosa, or in non-peritonealized pericolic or perirectal soft tissue without regional lymph node metastasis."@en .

obo:OBI_0002276 a obo:OBI_0002270 ;
  rdfs:label "pN2 (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 4 or more regional lymph nodes."@en .

obo:OBI_0002277 a obo:OBI_0002270 ;
  rdfs:label "pN2a (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 4 to 6 regional lymph nodes."@en .

obo:OBI_0002278 a obo:OBI_0002270 ;
  rdfs:label "pN2b (colon)" ;
  rdfs:comment "A pathologic lymph node stage for colon and rectum according to AJCC 7th edition indicating metastasis in 7 or more regional lymph nodes."@en .

obo:OBI_0002310 a rdfs:Class ;
  rdfs:label "pathologic distant metastases stage for ovary according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a  pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002311 a obo:OBI_0002310 ;
  rdfs:label "cM0 (ovary)" ;
  rdfs:comment "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is no distant metastasis."@en .

obo:OBI_0002312 a obo:OBI_0002310 ;
  rdfs:label "cM1 (ovary)" ;
  rdfs:comment "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is distant metastasis except peritoneal metastasis based on clinical assessment."@en .

obo:OBI_0002313 a obo:OBI_0002310 ;
  rdfs:label "pM1 (ovary)" ;
  rdfs:comment "A pathologic distant metastases stage for ovary according to AJCC 7th edition indicating that there is distant metastasis except peritoneal metastasis that is histologically confirmed."@en .

obo:OBI_0002314 a rdfs:Class ;
  rdfs:label "clinical tumor stage group according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is an assessment of the stage of a cancer according to the American Joint Committee on Cancer (AJCC) v7 staging systems."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002315 a obo:OBI_0002314 ;
  rdfs:label "Occult Carcinoma (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating a small carcinoma, either asymptomatic or giving rise to metastases without symptoms due to the primary carcinoma."@en .

obo:OBI_0002316 a obo:OBI_0002314 ;
  rdfs:label "Stage 0 (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating a carcinoma in situ (or melanoma in situ for melanoma of the skin or germ cell neoplasia in situ for testicular germ cell tumors) and generally is considered to have no metastatic potential."@en .

obo:OBI_0002317 a obo:OBI_0002314 ;
  rdfs:label "Stage I (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers that are smaller or less deeply invasive without regional disease or nodes."@en .

obo:OBI_0002318 a obo:OBI_0002314 ;
  rdfs:label "Stage IIA (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIB and IIC."@en .

obo:OBI_0002319 a obo:OBI_0002314 ;
  rdfs:label "Stage IIB (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIA and IIC."@en .

obo:OBI_0002320 a obo:OBI_0002314 ;
  rdfs:label "Stage IIC (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent but less than in Stage III and with differing characteristics from IIA and IIB."@en .

obo:OBI_0002321 a obo:OBI_0002314 ;
  rdfs:label "Stage IIIA (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIB and IIIC."@en .

obo:OBI_0002322 a obo:OBI_0002314 ;
  rdfs:label "Stage IIIB (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIA and IIIC."@en .

obo:OBI_0002323 a obo:OBI_0002314 ;
  rdfs:label "Stage IIIC (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers with increasing tumor or nodal extent greater than in Stage II and with differing characteristics from IIIA and IIIB."@en .

obo:OBI_0002324 a obo:OBI_0002314 ;
  rdfs:label "Stage IVA (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers in patients who present with distant metastases at diagnosis and with differing characteristics from IVB."@en .

obo:OBI_0002325 a obo:OBI_0002314 ;
  rdfs:label "Stage IVB (AJCC 7th)" ;
  rdfs:comment "A clinical tumor stage group according to AJCC 7th edition indicating cancers in patients who present with distant metastases at diagnosis and with differing characteristics from IVA."@en .

obo:UO_0000051 a rdfs:Class ;
  rdfs:label "concentration unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000062 a obo:UO_0000051 ;
  rdfs:label "molar" ;
  rdfs:comment "A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L)." .

obo:UO_0000063 a obo:UO_0000051 ;
  rdfs:label "millimolar" ;
  rdfs:comment "A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M." .

obo:UO_0000064 a obo:UO_0000051 ;
  rdfs:label "micromolar" ;
  rdfs:comment "A unit of molarity which is equal to one millionth of a molar or 10^[-6] M." .

obo:UO_0000065 a obo:UO_0000051 ;
  rdfs:label "nanomolar" ;
  rdfs:comment "A unit of molarity which is equal to one thousandth of one millionth of a molar or 10^[-9] M." .

obo:UO_0000066 a obo:UO_0000051 ;
  rdfs:label "picomolar" ;
  rdfs:comment "A unit of molarity which is equal to 10^[-12] M." .

obo:UO_0000163 a obo:UO_0000051 ;
  rdfs:label "mass percentage" ;
  rdfs:comment "A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture." .

obo:UO_0000164 a obo:UO_0000051 ;
  rdfs:label "mass volume percentage" ;
  rdfs:comment "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." .

obo:UO_0000165 a obo:UO_0000051 ;
  rdfs:label "volume percentage" ;
  rdfs:comment "A dimensionless concentration unit which denotes the volume of the solute in mL per 100 mL of the resulting solution." .

obo:UO_0000175 a obo:UO_0000051 ;
  rdfs:label "gram per liter" ;
  rdfs:comment "A mass unit density which is equal to mass of an object in grams divided by the volume in liters." .

obo:UO_0000176 a obo:UO_0000051 ;
  rdfs:label "milligram per milliliter" ;
  rdfs:comment "A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters." .

obo:UO_0000196 a obo:UO_0000051 ;
  rdfs:label "pH" ;
  rdfs:comment "A dimensionless concentration notation which denotes the acidity of a solution in terms of activity of hydrogen ions (H+)." .

obo:UO_0000207 a obo:UO_0000051 ;
  rdfs:label "milliliter per liter" ;
  rdfs:comment "A volume per unit volume unit which is equal to one millionth of a liter of solute in one liter of solution." .

obo:UO_0000208 a obo:UO_0000051 ;
  rdfs:label "gram per deciliter" ;
  rdfs:comment "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." .

obo:UO_0000212 a obo:UO_0000051 ;
  rdfs:label "colony forming unit per volume" ;
  rdfs:comment "A concentration unit which a measure of viable bacterial numbers in a given volume." .

obo:UO_0000301 a obo:UO_0000051 ;
  rdfs:label "microgram per liter" ;
  rdfs:comment "A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters." .

obo:OBI_0002341 a rdfs:Class ;
  rdfs:label "International Federation of Gynecology and Obstetrics ovarian cancer stage value specification" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the FIGO classification system."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002342 a obo:OBI_0002341 ;
  rdfs:label "Stage 1 (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1, N0, and M0."@en .

obo:OBI_0002343 a obo:OBI_0002341 ;
  rdfs:label "Stage 1A (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1a, N0, and M0."@en .

obo:OBI_0002344 a obo:OBI_0002341 ;
  rdfs:label "Stage 1B (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1b, N0, and M0."@en .

obo:OBI_0002345 a obo:OBI_0002341 ;
  rdfs:label "Stage 1C (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T1c, N0, and M0."@en .

obo:OBI_0002346 a obo:OBI_0002341 ;
  rdfs:label "Stage 2 (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2, N0, and M0."@en .

obo:OBI_0002347 a obo:OBI_0002341 ;
  rdfs:label "Stage 2A (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2a, N0, and M0."@en .

obo:OBI_0002348 a obo:OBI_0002341 ;
  rdfs:label "Stage 2B (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2b, N0, and M0."@en .

obo:OBI_0002349 a obo:OBI_0002341 ;
  rdfs:label "Stage 2C (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T2c, N0, and M0."@en .

obo:OBI_0002350 a obo:OBI_0002341 ;
  rdfs:label "Stage 3 (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T3, N0, and M0) or (T3,3a,3b, NX, and M0)."@en .

obo:OBI_0002351 a obo:OBI_0002341 ;
  rdfs:label "Stage 3A (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T3a, N0, and M0 ."@en .

obo:OBI_0002352 a obo:OBI_0002341 ;
  rdfs:label "Stage 3B (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of T3b, N0, and M0 ."@en .

obo:OBI_0002353 a obo:OBI_0002341 ;
  rdfs:label "Stage 3C (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T3c, N0,X and M0) or (any T, N1 and M0)."@en .

obo:OBI_0002354 a obo:OBI_0002341 ;
  rdfs:label "Stage 4 (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of any T, any N, and M1."@en .

obo:OBI_0002355 a obo:OBI_0002341 ;
  rdfs:label "Stage Unknown (FIGO)" ;
  rdfs:comment "A International Federation of Gynecology and Obstetrics ovarian cancer stage value specification associated with TNM stage values of (T0, N0, and M0) or (T1,1a-1c,2,2a-2c, NX, and M0) or (TX, N0,X, M0)."@en .

obo:OBI_0002287 a rdfs:Class ;
  rdfs:label "pathologic lymph node stage for ovary according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002288 a obo:OBI_0002287 ;
  rdfs:label "pN0 (ovary)" ;
  rdfs:comment "A pathologic lymph node stage for ovary according to AJCC 7th edition indicating that there is no regional lymph node metastasis."@en .

obo:OBI_0002289 a obo:OBI_0002287 ;
  rdfs:label "pN1 (ovary)" ;
  rdfs:comment "A pathologic lymph node stage for ovary according to AJCC 7th edition indicating that there is regional lymph node metastasis."@en .

obo:UO_0000105 a rdfs:Class ;
  rdfs:label "frequency unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000106 a obo:UO_0000105 ;
  rdfs:label "hertz" ;
  rdfs:comment "A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second." .

obo:OBI_0002224 a rdfs:Class ;
  rdfs:label "pathologic primary tumor stage for colon and rectum according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002225 a obo:OBI_0002224 ;
  rdfs:label "pT0 (colon)" ;
  rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .

obo:OBI_0002226 a obo:OBI_0002224 ;
  rdfs:label "pTis (colon)" ;
  rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating carcinoma in situ (intraepithelial or invasion of lamina propria)."@en .

obo:OBI_0002227 a obo:OBI_0002224 ;
  rdfs:label "pT1 (colon)" ;
  rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades submucosa."@en .

obo:OBI_0002228 a obo:OBI_0002224 ;
  rdfs:label "pT2 (colon)" ;
  rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades muscularis propria."@en .

obo:OBI_0002229 a obo:OBI_0002224 ;
  rdfs:label "pT3 (colon)" ;
  rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor invades subserosa or into non-peritionealized pericolic or perirectal tissues."@en .

obo:OBI_0002230 a obo:OBI_0002224 ;
  rdfs:label "pT4a (colon)" ;
  rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor perforates visceral peritoneum."@en .

obo:OBI_0002231 a obo:OBI_0002224 ;
  rdfs:label "pT4b (colon)" ;
  rdfs:comment "A pathologic primary tumor stage for colon and rectum according to AJCC 7th edition indicating that the tumor directly invades other organs or structures."@en .

obo:OBI_0002357 a rdfs:Class ;
  rdfs:label "Eastern Cooperative Oncology Group score value specification" ;
  rdfs:comment "A performance status value specification designed by the Eastern Cooperative Oncology Group to assess disease progression and its affect on the daily living abilities of the patient."@en ;
  rdfs:subClassOf obo:OBI_0002356 .

obo:OBI_0002358 a obo:OBI_0002357 ;
  rdfs:label "3: symptomatic in bed more than 50% of the day but not bed ridden" ;
  rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic and in bed for more than 50% of the day but is not bed ridden."@en .

obo:OBI_0002359 a obo:OBI_0002357 ;
  rdfs:label "2: symptomatic but in bed less than 50% of the day" ;
  rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic but is in bed for less than 50% of the day."@en .

obo:OBI_0002360 a obo:OBI_0002357 ;
  rdfs:label "4: bed ridden" ;
  rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic and is bed ridden."@en .

obo:OBI_0002361 a obo:OBI_0002357 ;
  rdfs:label "0: asymptomatic" ;
  rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is asymptomatic."@en .

obo:OBI_0002362 a obo:OBI_0002357 ;
  rdfs:label "1: symptomatic but fully ambulatory" ;
  rdfs:comment "An Eastern Cooperative Oncology Group score value specification indicating a patient is symptomatic but is fully ambulatory."@en .

obo:OBI_0002290 a rdfs:Class ;
  rdfs:label "pathologic distant metastases stage for colon according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of colon cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002291 a obo:OBI_0002290 ;
  rdfs:label "cM0 (colon)" ;
  rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there are no symptoms or signs of distant metastasis."@en .

obo:OBI_0002292 a obo:OBI_0002290 ;
  rdfs:label "cM1 (colon)" ;
  rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there is clinical evidence of distant metastases by history, physical examination, imaging studies, or invasive procedures, but without microscopic evidence of the presumed distant metastases."@en .

obo:OBI_0002293 a obo:OBI_0002290 ;
  rdfs:label "cM1a (colon)" ;
  rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is confined to one organ based on clinical assessment."@en .

obo:OBI_0002294 a obo:OBI_0002290 ;
  rdfs:label "cM1b (colon)" ;
  rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is in more than one organ or the peritoneum based on clinical assessment."@en .

obo:OBI_0002295 a obo:OBI_0002290 ;
  rdfs:label "pM1 (colon)" ;
  rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that there is microscopic evidence confirming distant metastatic disease."@en .

obo:OBI_0002296 a obo:OBI_0002290 ;
  rdfs:label "pM1a (colon)" ;
  rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is confined to one organ and histologically confirmed."@en .

obo:OBI_0002297 a obo:OBI_0002290 ;
  rdfs:label "pM1b (colon)" ;
  rdfs:comment "A pathologic distant metastases stage for colon according to AJCC 7th edition indicating that metastasis is in more than one organ or the peritoneum and histologically confirmed."@en .

obo:UO_0000005 a rdfs:Class ;
  rdfs:label "temperature unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000027 a obo:UO_0000005 ;
  rdfs:label "degree Celsius" ;
  rdfs:comment "A temperature unit which is equal to one kelvin degree. However, they have their zeros at different points. The centigrade scale has its zero at 273.15 K." .

obo:UO_0000195 a obo:UO_0000005 ;
  rdfs:label "degree Fahrenheit" ;
  rdfs:comment "A temperature unit which is equal to 5/9ths of a kelvin. Negative 40 degrees Fahrenheit is equal to negative 40 degrees Celsius." .

obo:OBI_0000963 a rdfs:Class ;
  rdfs:label "categorical label" ;
  rdfs:comment "A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale."@en ;
  rdfs:subClassOf obo:IAO_0000009 .

obo:OBI_0000958 a obo:OBI_0000963 ;
  rdfs:label "right handed" .

obo:OBI_0000979 a obo:OBI_0000963 ;
  rdfs:label "ambidexterous" .

obo:OBI_0000998 a obo:OBI_0000963 ;
  rdfs:label "left handed" .

obo:OBI_0002279 a rdfs:Class ;
  rdfs:label "pathologic lymph node stage for lung according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002280 a obo:OBI_0002279 ;
  rdfs:label "pN0 (lung)" ;
  rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating no regional lymph node metastasis."@en .

obo:OBI_0002281 a obo:OBI_0002279 ;
  rdfs:label "pN1 (lung)" ;
  rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension."@en .

obo:OBI_0002282 a obo:OBI_0002279 ;
  rdfs:label "pN2 (lung)" ;
  rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in ipsilateral mediastinal and/or subcarinal lymph node(s)."@en .

obo:OBI_0002283 a obo:OBI_0002279 ;
  rdfs:label "pN3 (lung)" ;
  rdfs:comment "A pathologic lymph node stage for lung according to AJCC 7th edition indicating metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)."@en .

obo:OBI_0002219 a rdfs:Class ;
  rdfs:label "histologic grade for ovarian tumor according to the World Health Organization" ;
  rdfs:comment "A histologic grade for ovarian tumor that is from a histological classification by the World Health Organization (WHO)."@en ;
  rdfs:subClassOf obo:OBI_0002215 .

obo:OBI_0002220 a obo:OBI_0002219 ;
  rdfs:label "G1 (WHO)" ;
  rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is well differentiated."@en .

obo:OBI_0002221 a obo:OBI_0002219 ;
  rdfs:label "G2 (WHO)" ;
  rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is moderately differentiated."@en .

obo:OBI_0002222 a obo:OBI_0002219 ;
  rdfs:label "G3 (WHO)" ;
  rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is poorly differentiated."@en .

obo:OBI_0002223 a obo:OBI_0002219 ;
  rdfs:label "G4 (WHO)" ;
  rdfs:comment "A histologic grade for ovarian tumor according to the World Health Organization indicating that the tumor is undifferentiated."@en .

obo:OBI_0002306 a rdfs:Class ;
  rdfs:label "pathologic distant metastases stage for kidney according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002307 a obo:OBI_0002306 ;
  rdfs:label "cM0 (kidney)" ;
  rdfs:comment "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there is no distant metastasis."@en .

obo:OBI_0002308 a obo:OBI_0002306 ;
  rdfs:label "cM1 (kidney)" ;
  rdfs:comment "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there are distant metastases based on clinical assessment."@en .

obo:OBI_0002309 a obo:OBI_0002306 ;
  rdfs:label "pM1 (kidney)" ;
  rdfs:comment "A pathologic distant metastases stage for kidney according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed."@en .

obo:UO_0000270 a rdfs:Class ;
  rdfs:label "volumetric flow rate unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000271 a obo:UO_0000270 ;
  rdfs:label "microliters per minute" ;
  rdfs:comment "A volumetric flow rate unit which is equal to one microliter volume through a given surface in one minute." .

obo:OBI_0002243 a rdfs:Class ;
  rdfs:label "pathologic primary tumor stage for kidney according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002244 a obo:OBI_0002243 ;
  rdfs:label "pT0 (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .

obo:OBI_0002245 a obo:OBI_0002243 ;
  rdfs:label "pT1 (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is 7 cm or less in greatest dimension and limited to the kidney."@en .

obo:OBI_0002246 a obo:OBI_0002243 ;
  rdfs:label "pT1a (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is 4 cm or less."@en .

obo:OBI_0002247 a obo:OBI_0002243 ;
  rdfs:label "pT1b (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 4 cm but not more than 7 cm."@en .

obo:OBI_0002248 a obo:OBI_0002243 ;
  rdfs:label "pT2 (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 7 cm in greatest dimension and limited to the kidney."@en .

obo:OBI_0002249 a obo:OBI_0002243 ;
  rdfs:label "pT2a (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 7 cm but not more than 10 cm."@en .

obo:OBI_0002250 a obo:OBI_0002243 ;
  rdfs:label "pT2b (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor is more than 10 cm and limited to the kidney."@en .

obo:OBI_0002251 a obo:OBI_0002243 ;
  rdfs:label "pT3 (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor extends into major veins or perinephric tissues but not into the ipsilateral adrenal gland and not beyond the Gerota fascia."@en .

obo:OBI_0002252 a obo:OBI_0002243 ;
  rdfs:label "pT3a (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into the renal vein or its segmental (muscle containing) branches, or the tumor invades perirenal and/or renal sinus fat (peripelvic) fat but not beyond Gerota fascia."@en .

obo:OBI_0002253 a obo:OBI_0002243 ;
  rdfs:label "pT3b (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into vena cava below diaphragm."@en .

obo:OBI_0002254 a obo:OBI_0002243 ;
  rdfs:label "pT3c (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor grossly extends into vena cava above the diaphragm or Invades the wall of the vena cava."@en .

obo:OBI_0002255 a obo:OBI_0002243 ;
  rdfs:label "pT4 (kidney)" ;
  rdfs:comment "A pathologic primary tumor stage for kidney according to AJCC 7th edition indicating that the tumor invades beyond Gerota fascia (including contiguous extension into the ipsilateral adrenal gland)."@en .

obo:IAO_0000225 a rdfs:Class ;
  rdfs:label "obsolescence reason specification"@en ;
  rdfs:comment "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
  rdfs:subClassOf obo:IAO_0000102 .

obo:IAO_0000103 a obo:IAO_0000225 ;
  rdfs:label "failed exploratory term"@en ;
  rdfs:comment "The term was initially used in an attempt to structure part of the ontology, but in retrospect failed to do a good job."@en .

obo:IAO_0000226 a obo:IAO_0000225 ;
  rdfs:label "placeholder removed"@en ;
  rdfs:comment "The term was created to temporarily stand in for a semantic purpose, but is no longer needed, typically due to another permanent term being defined."@en .

obo:IAO_0000227 a obo:IAO_0000225 ;
  rdfs:label "terms merged"@en ;
  rdfs:comment "The term has been combined with one or more other terms to create a more encompassing (merged) term."@en .

obo:IAO_0000228 a obo:IAO_0000225 ;
  rdfs:label "term imported"@en ;
  rdfs:comment "The term has been replaced by a term imported from another ontology."@en .

obo:IAO_0000229 a obo:IAO_0000225 ;
  rdfs:label "term split"@en ;
  rdfs:comment "The term has been split into two or more new terms."@en .

obo:OMO_0001000 a obo:IAO_0000225 ;
  rdfs:label "out of scope" ;
  rdfs:comment "The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not."@en .

obo:UO_0000280 a rdfs:Class ;
  rdfs:label "rate unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000281 a obo:UO_0000280 ;
  rdfs:label "count per nanomolar second" ;
  rdfs:comment "A rate unit which is equal to one over one nanomolar second." .

obo:UO_0000282 a obo:UO_0000280 ;
  rdfs:label "count per molar second" ;
  rdfs:comment "A rate unit which is equal to one over one molar second." .

obo:UO_0000284 a obo:UO_0000280 ;
  rdfs:label "count per nanomolar" ;
  rdfs:comment "A rate unit which is equal to one over one nanomolar." .

obo:UO_0000285 a obo:UO_0000280 ;
  rdfs:label "count per molar" ;
  rdfs:comment "A rate unit which is equal to one over one molar." .

obo:UO_0000006 a rdfs:Class ;
  rdfs:label "substance unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000039 a obo:UO_0000006 ;
  rdfs:label "micromole" ;
  rdfs:comment "A substance unit equal to a millionth of a mol or 10^[-6] mol." .

obo:UO_0000041 a obo:UO_0000006 ;
  rdfs:label "nanomole" ;
  rdfs:comment "A substance unit equal to one thousandth of one millionth of a mole or 10^[-9] mol." .

obo:UO_0000042 a obo:UO_0000006 ;
  rdfs:label "picomole" ;
  rdfs:comment "A substance unit equal to 10^[-12] mol." .

obo:IAO_0000409 a rdfs:Class ;
  rdfs:label "denotator type"@en ;
  rdfs:comment "A denotator type indicates how a term should be interpreted from an ontological perspective."@en ;
  rdfs:subClassOf obo:IAO_0000102 .

obo:IAO_0000410 a obo:IAO_0000409 ;
  rdfs:label "universal"@en .

obo:IAO_0000420 a obo:IAO_0000409 ;
  rdfs:label "defined class"@en ;
  rdfs:comment "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en .

obo:IAO_0000421 a obo:IAO_0000409 ;
  rdfs:label "named class expression"@en ;
  rdfs:comment "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en .

obo:OBI_0002216 a rdfs:Class ;
  rdfs:label "histologic grade for ovarian tumor according to a two-tier grading system" ;
  rdfs:comment "A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors."@en ;
  rdfs:subClassOf obo:OBI_0002215 .

obo:OBI_0002217 a obo:OBI_0002216 ;
  rdfs:label "Low grade ovarian tumor" ;
  rdfs:comment "A histologic grade for ovarian tumor according to a two-tier grading system indicating that the tumor is low grade."@en .

obo:OBI_0002218 a obo:OBI_0002216 ;
  rdfs:label "High grade ovarian tumor" ;
  rdfs:comment "A histologic grade for ovarian tumor according to a two-tier grading system indicating that the tumor is high grade."@en .

obo:OBI_0000713 a rdfs:Class ;
  rdfs:label "GenePattern software" ;
  rdfs:comment "a software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks."@en ;
  rdfs:subClassOf obo:IAO_0000010 .

obo:OBI_0000761 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module SVM" ;
  rdfs:comment "GenePattern module SVM is a GenePattern software module which is used to run a support vector machine data transformation."@en .

obo:OBI_0000766 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module KMeansClustering" ;
  rdfs:comment "GenePattern module KMeansClustering is a GenePattern software module which is used to perform a k Means clustering data transformation."@en .

obo:OBI_0000768 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module CARTXValidation" ;
  rdfs:comment "GenePattern module CARTXValidation is a GenePattern software module which uses a CART decision tree induction with a leave one out cross validation data transformations."@en .

obo:OBI_0000771 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module KNNXValidation" ;
  rdfs:comment "GenePattern module KNNXValidation is a GenePattern software module which uses a k-nearest neighbours clustering with a leave one out cross validation data transformations."@en .

obo:OBI_0000772 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module PeakMatch" .

obo:OBI_0000773 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module KNN" ;
  rdfs:comment "GenePattern module KNN is a GenePattern software module which perform a k-nearest neighbors data transformation."@en .

obo:OBI_0000774 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module HierarchicalClustering" ;
  rdfs:comment "GenePattern module HierarchicalClustering is a GenePattern software module which is used to perform a hierarchical clustering data transformation."@en .

obo:OBI_0000777 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module PCA" ;
  rdfs:comment "GenePattern module PCA is a GenePattern software module which is used to perform a principal components analysis dimensionality reduction data transformation."@en .

obo:OBI_0000782 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module HeatMapViewer" ;
  rdfs:comment "A GenePattern software module which is used to generate a heatmap view of data."@en .

obo:OBI_0000783 a obo:OBI_0000713 ;
  rdfs:label "GenePattern module HierarchicalClusteringViewer" ;
  rdfs:comment "A GenePattern software module which is used to generate a view of data that has been hierarchically clustered."@en .

obo:OBI_0002205 a rdfs:Class ;
  rdfs:label "histologic grade according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the American Joint Committee on Cancer (AJCC) 7th Edition grading system."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002206 a obo:OBI_0002205 ;
  rdfs:label "G1: Well differentiated" ;
  rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells and the organization of the tumor tissue appear close to normal."@en .

obo:OBI_0002207 a obo:OBI_0002205 ;
  rdfs:label "G2: Moderately differentiated" ;
  rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells are moderately differentiated and reflect an intermediate grade."@en .

obo:OBI_0002208 a obo:OBI_0002205 ;
  rdfs:label "G3: Poorly differentiated" ;
  rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells are poorly differentiated and do not look like normal cells and tissue."@en .

obo:OBI_0002209 a obo:OBI_0002205 ;
  rdfs:label "G4: Undifferentiated" ;
  rdfs:comment "A histologic grade according to AJCC 7th edition indicating that the tumor cells are undifferentiated and do not look like normal cells and tissue."@en .

obo:UO_0000003 a rdfs:Class ;
  rdfs:label "time unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000010 a obo:UO_0000003 ;
  rdfs:label "second" ;
  rdfs:comment "A time unit which is equal to the duration of 9 192 631 770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom." .

obo:UO_0000031 a obo:UO_0000003 ;
  rdfs:label "minute" ;
  rdfs:comment "A time unit which is equal to 60 seconds." .

obo:UO_0000032 a obo:UO_0000003 ;
  rdfs:label "hour" ;
  rdfs:comment "A time unit which is equal to 3600 seconds or 60 minutes." .

obo:UO_0000033 a obo:UO_0000003 ;
  rdfs:label "day" ;
  rdfs:comment "A time unit which is equal to 24 hours." .

obo:UO_0000034 a obo:UO_0000003 ;
  rdfs:label "week" ;
  rdfs:comment "A time unit which is equal to 7 days." .

obo:UO_0000035 a obo:UO_0000003 ;
  rdfs:label "month" ;
  rdfs:comment "A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days." .

obo:UO_0000036 a obo:UO_0000003 ;
  rdfs:label "year" ;
  rdfs:comment "A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days." .

obo:OBI_0002298 a rdfs:Class ;
  rdfs:label "pathologic distant metastases stage for lung according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002299 a obo:OBI_0002298 ;
  rdfs:label "cM0 (lung)" ;
  rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is no distant metastasis."@en .

obo:OBI_0002300 a obo:OBI_0002298 ;
  rdfs:label "cM1 (lung)" ;
  rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there are distant metastases based on clinical assessment."@en .

obo:OBI_0002301 a obo:OBI_0002298 ;
  rdfs:label "cM1a (lung)" ;
  rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that metastasis is based on clinical assessment and a separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules OR malignant pleural or pericardial effusion."@en .

obo:OBI_0002302 a obo:OBI_0002298 ;
  rdfs:label "cM1b (lung)" ;
  rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases based on clinical assessment."@en .

obo:OBI_0002303 a obo:OBI_0002298 ;
  rdfs:label "pM1 (lung)" ;
  rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed."@en .

obo:OBI_0002304 a obo:OBI_0002298 ;
  rdfs:label "pM1a (lung)" ;
  rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that metastasis is histologically confirmed and a separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules OR malignant pleural or pericardial effusion."@en .

obo:OBI_0002305 a obo:OBI_0002298 ;
  rdfs:label "pM1b (lung)" ;
  rdfs:comment "A pathologic distant metastases stage for lung according to AJCC 7th edition indicating that there is a distant metastases that is histologically confirmed and associated with distant lymph nodes or carcinomatosis."@en .

obo:UO_0000095 a rdfs:Class ;
  rdfs:label "volume unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000097 a obo:UO_0000095 ;
  rdfs:label "cubic centimeter" ;
  rdfs:comment "A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml." .

obo:UO_0000098 a obo:UO_0000095 ;
  rdfs:label "milliliter" ;
  rdfs:comment "A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter." .

obo:UO_0000099 a obo:UO_0000095 ;
  rdfs:label "liter" ;
  rdfs:comment "A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter." .

obo:UO_0000100 a obo:UO_0000095 ;
  rdfs:label "cubic decimeter" ;
  rdfs:comment "A volume unit which is equal to one thousand of a cubic meter or 10^[-3] m^[3], or to 1 L." .

obo:UO_0000101 a obo:UO_0000095 ;
  rdfs:label "microliter" ;
  rdfs:comment "A volume unit which is equal to one millionth of a liter or 10^[-6] L." .

obo:UO_0000102 a obo:UO_0000095 ;
  rdfs:label "nanoliter" ;
  rdfs:comment "A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L." .

obo:UO_0000103 a obo:UO_0000095 ;
  rdfs:label "picoliter" ;
  rdfs:comment "A volume unit which is equal to 10^[-12] L." .

obo:OBI_0001000 a rdfs:Class ;
  rdfs:label "questionnaire" ;
  rdfs:comment "A document with a set of printed or written questions with a choice of answers, devised for the purposes of a survey or statistical study."@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0001004 a obo:OBI_0001000 ;
  rdfs:label "Edingburgh handedness inventory" ;
  rdfs:comment "The Edinburgh Handedness Inventory is a set of questions used to assess the dominance of a person's right or left hand in everyday activities."@en .

obo:UO_0000001 a rdfs:Class ;
  rdfs:label "length unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000008 a obo:UO_0000001 ;
  rdfs:label "meter" ;
  rdfs:comment "A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second." .

obo:UO_0000015 a obo:UO_0000001 ;
  rdfs:label "centimeter" ;
  rdfs:comment "A length unit which is equal to one hundredth of a meter or 10^[-2] m." .

obo:UO_0000016 a obo:UO_0000001 ;
  rdfs:label "millimeter" ;
  rdfs:comment "A length unit which is equal to one thousandth of a meter or 10^[-3] m." .

obo:UO_0000017 a obo:UO_0000001 ;
  rdfs:label "micrometer" ;
  rdfs:comment "A length unit which is equal to one millionth of a meter or 10^[-6] m." .

obo:UO_0000018 a obo:UO_0000001 ;
  rdfs:label "nanometer" ;
  rdfs:comment "A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m." .

obo:UO_0000019 a obo:UO_0000001 ;
  rdfs:label "angstrom" ;
  rdfs:comment "A length unit which is equal to 10 [-10] m." .

obo:OBI_0200051 a rdfs:Class ;
  rdfs:label "principal components analysis dimensionality reduction"@en ;
  rdfs:comment "A principal components analysis dimensionality reduction is a dimensionality reduction achieved by applying principal components analysis and by keeping low-order principal components and excluding higher-order ones."@en ;
  rdfs:subClassOf obo:OBI_0200050 .

obo:OBI_0000760 a obo:OBI_0200051 ;
  rdfs:label "GenePattern PCA" .

obo:OBI_0002326 a rdfs:Class ;
  rdfs:label "International Federation of Gynecology and Obstetrics cervical cancer stage value specification" ;
  rdfs:comment "A categorical value specification that is an assessment of the stage of a gynecologic cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging systems."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002327 a obo:OBI_0002326 ;
  rdfs:label "Stage IA (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating invasive carcinoma which can be diagnosed only by microscopy, with deepest invasion <5 mm and the largest extension <7 mm."@en .

obo:OBI_0002328 a obo:OBI_0002326 ;
  rdfs:label "Stage IA1 (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating measured stromal invasion of <3.0 mm in depth and extension of <7.0 mm."@en .

obo:OBI_0002329 a obo:OBI_0002326 ;
  rdfs:label "Stage IA2 (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating measured stromal invasion of >3.0 mm and not >5.0 mm with an extension of not >7.0 mm."@en .

obo:OBI_0002330 a obo:OBI_0002326 ;
  rdfs:label "Stage IB (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesions limited to the cervix uteri or pre-clinical cancers greater than stage IA"@en .

obo:OBI_0002331 a obo:OBI_0002326 ;
  rdfs:label "Stage IB1 (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesion limited to the cervix uteri or pre-clinical cancers greater than stage IA <4.0 cm in greatest dimension."@en .

obo:OBI_0002332 a obo:OBI_0002326 ;
  rdfs:label "Stage IB2 (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating clinically visible lesion limited to the cervix uteri or pre-clinical cancers greater than stage IA >4.0 cm in greatest dimension."@en .

obo:OBI_0002333 a obo:OBI_0002326 ;
  rdfs:label "Stage IIA (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion."@en .

obo:OBI_0002334 a obo:OBI_0002326 ;
  rdfs:label "Stage IIA1 (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion <4.0 cm in greatest dimension."@en .

obo:OBI_0002335 a obo:OBI_0002326 ;
  rdfs:label "Stage IIA2 (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion >4.0 cm in greatest dimension."@en .

obo:OBI_0002336 a obo:OBI_0002326 ;
  rdfs:label "Stage IIB (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina with obvious parametrial invasion."@en .

obo:OBI_0002337 a obo:OBI_0002326 ;
  rdfs:label "Stage IIIA (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating tumour involves lower third of the vagina, with no extension to the pelvic wall."@en .

obo:OBI_0002338 a obo:OBI_0002326 ;
  rdfs:label "Stage IIIB (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating extension to the pelvic wall and/or hydronephrosis or non-functioning kidney."@en .

obo:OBI_0002339 a obo:OBI_0002326 ;
  rdfs:label "Stage IVA (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating spread of the growth to adjacent organs."@en .

obo:OBI_0002340 a obo:OBI_0002326 ;
  rdfs:label "Stage IVB (FIGO)" ;
  rdfs:comment "An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating spread to distant organs."@en .

obo:OBI_0002284 a rdfs:Class ;
  rdfs:label "pathologic lymph node stage for kidney according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002285 a obo:OBI_0002284 ;
  rdfs:label "pN0 (kidney)" ;
  rdfs:comment "A pathologic lymph node stage for kidney according to AJCC 7th edition indicating that there is no regional lymph node metastasis."@en .

obo:OBI_0002286 a obo:OBI_0002284 ;
  rdfs:label "pN1 (kidney)" ;
  rdfs:comment "A pathologic lymph node stage for kidney according to AJCC 7th edition indicating that there is regional lymph node metastasis."@en .

obo:OBI_0000726 a rdfs:Class ;
  rdfs:label "peak matching" ;
  rdfs:comment "Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold"@en ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0000778 a obo:OBI_0000726 ;
  rdfs:label "GenePattern peak matching" .

obo:OBI_0002363 a rdfs:Class ;
  rdfs:label "Karnofsky score vaue specification" ;
  rdfs:comment "A performance status value specification designed for classifying patients 16 years of age or older by their functional impairment."@en ;
  rdfs:subClassOf obo:OBI_0002356 .

obo:OBI_0002364 a obo:OBI_0002363 ;
  rdfs:label "100: asymptomatic" ;
  rdfs:comment "A Karnofsky score vaue specification indicating that a patient is asymptomatic."@en .

obo:OBI_0002365 a obo:OBI_0002363 ;
  rdfs:label "80-90: symptomatic but fully ambulatory" ;
  rdfs:comment "A Karnofsky score vaue specification indicating that a patient is symptomatic but fully ambulatory."@en .

obo:OBI_0002366 a obo:OBI_0002363 ;
  rdfs:label "60-70: symptomatic but in bed less than 50% of the day" ;
  rdfs:comment "A Karnofsky score vaue specification indicating that a patient is symptomatic but in bed less than 50% of the day."@en .

obo:OBI_0002367 a obo:OBI_0002363 ;
  rdfs:label "40-50: symptomatic, in bed more than 50% of the day, but not bed ridden" ;
  rdfs:comment "A Karnofsky score vaue specification indicating that a patient is symptomatic, in bed more than 50% of the day, but not bed ridden."@en .

obo:OBI_0002210 a rdfs:Class ;
  rdfs:label "histologic grade according to the Fuhrman Nuclear Grading System" ;
  rdfs:comment "A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the Fuhrman Nuclear Grading System."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002211 a obo:OBI_0002210 ;
  rdfs:label "G1 (Fuhrman)" ;
  rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are round, uniform, approximately 10um and that nucleoli are inconspicuous or absent."@en .

obo:OBI_0002212 a obo:OBI_0002210 ;
  rdfs:label "G2 (Fuhrman)" ;
  rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are slightly irregular, approximately 15um and nucleoli are evident."@en .

obo:OBI_0002213 a obo:OBI_0002210 ;
  rdfs:label "G3 (Fuhrman)" ;
  rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei are very irregular, approximately 20um and nucleoli large and prominent."@en .

obo:OBI_0002214 a obo:OBI_0002210 ;
  rdfs:label "G4 (Fuhrman)" ;
  rdfs:comment "A histologic grade according to the Fuhrman Nuclear Grading System indicating that nuclei arei bizarre and multilobulated, 20um or greater and nucleoli are prominent and chromatin clumped."@en .

obo:UO_0000002 a rdfs:Class ;
  rdfs:label "mass unit" ;
  rdfs:subClassOf obo:IAO_0000003 .

obo:UO_0000009 a obo:UO_0000002 ;
  rdfs:label "kilogram" ;
  rdfs:comment "A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France." .

obo:UO_0000021 a obo:UO_0000002 ;
  rdfs:label "gram" ;
  rdfs:comment "A mass unit which is equal to one thousandth of a kilogram or 10^[-3] kg." .

obo:UO_0000022 a obo:UO_0000002 ;
  rdfs:label "milligram" ;
  rdfs:comment "A mass unit which is equal to one thousandth of a gram or 10^[-3] g." .

obo:UO_0000023 a obo:UO_0000002 ;
  rdfs:label "microgram" ;
  rdfs:comment "A mass unit which is equal to one millionth of a gram or 10^[-6] g." .

obo:UO_0000024 a obo:UO_0000002 ;
  rdfs:label "nanogram" ;
  rdfs:comment "A mass unit which is equal to one thousandth of one millionth of a gram or 10^[-9] g." .

obo:UO_0000025 a obo:UO_0000002 ;
  rdfs:label "picogram" ;
  rdfs:comment "A mass unit which is equal to 10^[-12] g." .

obo:IAO_0000078 a rdfs:Class ;
  rdfs:label "curation status specification"@en ;
  rdfs:comment "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
  rdfs:subClassOf obo:IAO_0000102 .

obo:IAO_0000002 a obo:IAO_0000078 ;
  rdfs:label "example to be eventually removed"@en .

obo:IAO_0000120 a obo:IAO_0000078 ;
  rdfs:label "metadata complete"@en ;
  rdfs:comment "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en .

obo:IAO_0000121 a obo:IAO_0000078 ;
  rdfs:label "organizational term"@en ;
  rdfs:comment "The term was created to ease viewing/sorting terms for development purposes, but will not be included in a release."@en .

obo:IAO_0000122 a obo:IAO_0000078 ;
  rdfs:label "ready for release"@en ;
  rdfs:comment "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release.  Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""@en .

obo:IAO_0000123 a obo:IAO_0000078 ;
  rdfs:label "metadata incomplete"@en ;
  rdfs:comment "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en .

obo:IAO_0000124 a obo:IAO_0000078 ;
  rdfs:label "uncurated"@en ;
  rdfs:comment "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en .

obo:IAO_0000125 a obo:IAO_0000078 ;
  rdfs:label "pending final vetting"@en ;
  rdfs:comment "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en .

obo:IAO_0000423 a obo:IAO_0000078 ;
  rdfs:label "to be replaced with external ontology term"@en ;
  rdfs:comment "Terms with this status should eventually replaced with a term from another ontology."@en .

obo:IAO_0000428 a obo:IAO_0000078 ;
  rdfs:label "requires discussion"@en ;
  rdfs:comment "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en .

obo:OBI_0002256 a rdfs:Class ;
  rdfs:label "pathologic primary tumor stage for ovary according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002257 a obo:OBI_0002256 ;
  rdfs:label "pT0 (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .

obo:OBI_0002258 a obo:OBI_0002256 ;
  rdfs:label "pT1 (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to the ovaries (one or both)."@en .

obo:OBI_0002259 a obo:OBI_0002256 ;
  rdfs:label "pT1a (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to one ovary; capsule intact, no tumor on ovarian surface and no malignant cells in ascites or peritoneal washings."@en .

obo:OBI_0002260 a obo:OBI_0002256 ;
  rdfs:label "pT1b (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to both ovaries; capsule intact, no tumor on ovarian surface and no malignant cells in ascites or peritoneal washings."@en .

obo:OBI_0002261 a obo:OBI_0002256 ;
  rdfs:label "pT1c (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor is limited to one or both ovaries with capsule ruptured, tumor on ovarian surface, or malignant cells in ascites or peritoneal washings."@en .

obo:OBI_0002262 a obo:OBI_0002256 ;
  rdfs:label "pT2 (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor involves one or both ovaries with pelvic extension."@en .

obo:OBI_0002263 a obo:OBI_0002256 ;
  rdfs:label "pT2a (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has extension and/or implants on uterus and/or tube(s) and no malignant cells in ascites or peritoneal washings."@en .

obo:OBI_0002264 a obo:OBI_0002256 ;
  rdfs:label "pT2b (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has extension to other pelvic tissues and no malignant cells in ascites or peritoneal washings."@en .

obo:OBI_0002265 a obo:OBI_0002256 ;
  rdfs:label "pT2c (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has pelvic extension with malignant cells in ascites or peritoneal washings."@en .

obo:OBI_0002266 a obo:OBI_0002256 ;
  rdfs:label "pT3 (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis and/or regional lymph node metastasis."@en .

obo:OBI_0002267 a obo:OBI_0002256 ;
  rdfs:label "pT3a (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has microscopic peritoneal metastasis beyond pelvis."@en .

obo:OBI_0002268 a obo:OBI_0002256 ;
  rdfs:label "pT3b (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has macroscopic peritoneal, metastatasis beyond pelvis, 2 cm or less in greatest dimension."@en .

obo:OBI_0002269 a obo:OBI_0002256 ;
  rdfs:label "pT3c (ovary)" ;
  rdfs:comment "A pathologic primary tumor stage for ovary according to AJCC 7th edition indicating that the tumor has peritoneal metastasis beyond pelvis, more than 2 cm in greatest dimension and/or regional lymph node metastasis."@en .

obo:OBI_0002232 a rdfs:Class ;
  rdfs:label "pathologic primary tumor stage for lung according to AJCC 7th edition" ;
  rdfs:comment "A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery."@en ;
  rdfs:subClassOf obo:OBI_0001930 .

obo:OBI_0002233 a obo:OBI_0002232 ;
  rdfs:label "pT0 (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that there is no evidence of primary tumor."@en .

obo:OBI_0002234 a obo:OBI_0002232 ;
  rdfs:label "pTis (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating carcinoma in situ."@en .

obo:OBI_0002235 a obo:OBI_0002232 ;
  rdfs:label "pT1 (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus)."@en .

obo:OBI_0002236 a obo:OBI_0002232 ;
  rdfs:label "pT1a (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is 2 cm or less in greatest dimension."@en .

obo:OBI_0002237 a obo:OBI_0002232 ;
  rdfs:label "pT1b (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 2 cm but not more than 3 cm in greatest dimension."@en .

obo:OBI_0002238 a obo:OBI_0002232 ;
  rdfs:label "pT2 (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 3 cm but not more than 7 cm or the tumor has any of the following features: involves main bronchus, 2 cm or more distal to the carina, invades visceral pleura, associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung."@en .

obo:OBI_0002239 a obo:OBI_0002232 ;
  rdfs:label "pT2a (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 3 cm but not more than 5 cm in greatest dimension."@en .

obo:OBI_0002240 a obo:OBI_0002232 ;
  rdfs:label "pT2b (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 5 cm but not more than 7 cm in greatest dimension."@en .

obo:OBI_0002241 a obo:OBI_0002232 ;
  rdfs:label "pT3 (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor is more than 7 cm or one that directly invades any of: parietal pleura, chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardiu or the tumor is in the main bronchus less than 2 cm distal to the carina but without  involvement of the carina or there is associated atelectasis or obstructive pneumonitis of the entire lung or there is separate tumor nodule(s) in the same lobe as the primary."@en .

obo:OBI_0002242 a obo:OBI_0002232 ;
  rdfs:label "pT4 (lung)" ;
  rdfs:comment "A pathologic primary tumor stage for lung according to AJCC 7th edition indicating that the tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina or there is separate tumor nodule(s) in a different ipsilateral lobe to that of the primary."@en .
