PREFIX obo: <http://purl.obolibrary.org/obo/>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

obo:CL_0002253 a rdfs:Class ;
  rdfs:label "epithelial cell of large intestine" ;
  rdfs:comment "An epithelial cell of the large intestine." ;
  rdfs:subClassOf obo:CL_0002563 .

obo:RO_0002595 a rdf:Property ;
  rdfs:label "causal relation between material entity and a process" ;
  rdfs:comment "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0001025 a rdf:Property ;
  rdfs:label "located_in (type level)" ;
  rdfs:comment "a relation between two independent continuants, the target and the location, in which the target is entirely within the location"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0010002 a rdf:Property ;
  rdfs:label "is carrier of"@en ;
  rdfs:comment "*b* is carrier of *c* at time *t* if and only if *c* *g-depends on* *b* at *t*" ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000031 .

obo:RO_0001018 a rdf:Property ;
  rdfs:label "contained in"@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000004 .

obo:RO_0000087 a rdf:Property ;
  rdfs:label "has_role" ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000023 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:OMIABIS_0000048 a rdf:Property ;
  rdfs:label "is owned by"@en ;
  rdfs:comment "a is owned by b if b has complete power over a. All rights and obligations of ownership are grounded in this (primitive) relation. The claims and obligations of ownership can be partially transferred to a third party by the owner, b."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002330 a rdf:Property ;
  rdfs:label "genomically related to"@en ;
  rdfs:comment "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 .

obo:RO_0000085 a rdf:Property ;
  rdfs:label "has function"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000004 ;
  rdfs:range obo:BFO_0000034 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0002206 a rdf:Property ;
  rdfs:label "expressed in"@en ;
  rdfs:comment "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0000056 a rdf:Property ;
  rdfs:label "participates in"@en ;
  rdfs:comment "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:BFO_0000003 .

obo:OBI_0000304 a rdf:Property ;
  rdfs:label "is_manufactured_by"@en ;
  rdfs:comment "c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the \"Manufacturer Role\", and those people/and or machines were members or of directed by the organization to do this."@en ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002506 a rdf:Property ;
  rdfs:label "causal relation between material entities" ;
  rdfs:domain obo:BFO_0000040 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:OBIB_0000301 a rdfs:Class ;
  rdfs:label "FFPE clearing agent duration" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration in clearing agent in the formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OMIABIS_0000042 a rdf:Property ;
  rdfs:label "is contact information about"@en ;
  rdfs:comment "a is contact information for b, if a is a information content entity, b is a human being or an organization and a identifies a physical location or electronic resource that allows to initiate communication with a."@en ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:OBI_0001938 a rdf:Property ;
  rdfs:label "has value specification" ;
  rdfs:comment "A relation between an information content entity and a value specification that specifies its value." ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:IAO_0000413 a rdf:Property ;
  rdfs:label "is duration of"@en ;
  rdfs:comment "relates a process to a time-measurement-datum that represents the duration of the process"@en ;
  rdfs:domain obo:IAO_0000416 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:IAO_0000221 a rdf:Property ;
  rdfs:label "is quality measurement of"@en ;
  rdfs:comment """m is a quality measurement of q at t when
q is a quality 
there is a measurement process p that has specified output m, a measurement datum, that is about q"""@en ;
  rdfs:domain obo:IAO_0000109 ;
  rdfs:range obo:BFO_0000019 ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:IAO_0020012 a rdf:Property ;
  rdfs:label "designates"@en ;
  rdfs:comment "x designates y, if for any given group of language users, x is an information content entity, is about y, and represents y in a linguistic context.."@en ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range obo:BFO_0000001 .

<http://www.ebi.ac.uk/swo/SWO_0004002> a rdf:Property ;
  rdfs:label "has format specification" ;
  rdfs:comment "Has format specification is a type of \"is encoded in\" relationship which specifically describes the relationship between data and a data format specification." ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://www.ebi.ac.uk/efo/swo/SWO_0000741> .

obo:IAO_0000136 a rdf:Property ;
  rdfs:label "is about" ;
  rdfs:comment "is_about is a (currently) primitive relation that relates an information artifact to an entity."@en ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0010001 a rdf:Property ;
  rdfs:label "generically depends on" ;
  rdfs:comment "A generically dependent continuant *b* generically depends on an independent continuant *c* at time *t* means: there inheres in *c* a specifically deendent continuant which concretizes *b* at *t*." ;
  rdfs:domain obo:BFO_0000031 ;
  rdfs:range obo:BFO_0000004 .

obo:NCBITaxon_117571 a rdfs:Class ;
  rdfs:label "Euteleostomi" ;
  rdfs:subClassOf obo:NCBITaxon_7742 .

obo:FLU_0001019 a rdfs:Class ;
  rdfs:label "specimen barcode" ;
  rdfs:comment "A specimen barcode is a specimen identification number formatted as an optical machine-readable representation."@en ;
  rdfs:subClassOf obo:OBI_0001616 .

obo:IAO_0000219 a rdf:Property ;
  rdfs:label "denotes"@en ;
  rdfs:comment "denotes is a primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically"@en ;
  rdfs:domain obo:IAO_0000030 ;
  rdfs:range obo:OBI_0100051 ;
  rdfs:subPropertyOf obo:IAO_0000136 .

<http://semanticscience.org/resource/SIO_000254> a rdf:Property ;
  rdfs:label "is annotation of"@en ;
  rdfs:domain <http://semanticscience.org/resource/SIO_000078> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000011> .

<http://semanticscience.org/resource/SIO_000672> a rdf:Property ;
  rdfs:label "is identifier for"@en ;
  rdfs:domain <http://semanticscience.org/resource/SIO_000115> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000011> .

obo:OBI_0002399 a rdfs:Class ;
  rdfs:label "unilateral oophorectomy history" ;
  rdfs:comment "A gynecologic surgery history in which a woman has had a unilateral oophorectomy." ;
  rdfs:subClassOf obo:OBI_0002397 .

obo:OBI_0002544 a rdfs:Class ;
  rdfs:label "esophagogastric junction specimen" ;
  rdfs:comment "A specimen that is derived from the esophagogastric junction." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000371 a rdfs:Class ;
  rdfs:label "heat function"@en ;
  rdfs:comment "A heat function is a function that increases the internal kinetic energy of a material"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:RO_0000059 a rdf:Property ;
  rdfs:label "concretizes"@en ;
  rdfs:comment "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ;
  rdfs:domain obo:BFO_0000020 ;
  rdfs:range obo:BFO_0000031 .

obo:RO_0000079 a rdf:Property ;
  rdfs:label "function of"@en ;
  rdfs:comment "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ;
  rdfs:domain obo:BFO_0000034 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0004000 a rdf:Property ;
  rdfs:label "condition has genetic basis in" ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004028 a rdf:Property ;
  rdfs:label "realized in response to stimulus" ;
  rdfs:comment "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:BFO_0000054 a rdf:Property ;
  rdfs:label "realized in"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000015 , obo:OBI_0000415 .

obo:RO_0009501 a rdf:Property ;
  rdfs:label "realized in response to"@en ;
  rdfs:comment "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." ;
  rdfs:seeAlso <https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit> ;
  rdfs:domain obo:BFO_0000017 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:CL_0000080 a rdfs:Class ;
  rdfs:label "circulating cell" ;
  rdfs:comment "A cell which moves among different tissues of the body, via blood, lymph, or other medium." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0001892 a rdfs:Class ;
  rdfs:label "specification of data to be generated in an investigation"@en ;
  rdfs:comment "An objective specification which indicates the type of data that will be generated and submitted to a database." ;
  rdfs:subClassOf obo:OBI_0000684 .

obo:CL_0001009 a rdfs:Class ;
  rdfs:label "immature dermal dendritic cell" ;
  rdfs:subClassOf obo:CL_0001006 .

obo:CL_0002398 a rdfs:Class ;
  rdfs:label "Gr1-positive, CD43-positive monocyte" ;
  rdfs:subClassOf obo:CL_0002393 .

obo:OBI_0000681 a rdfs:Class ;
  rdfs:label "separation into different composition objective" ;
  rdfs:comment "A material separation objective aiming to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities)." ;
  rdfs:subClassOf obo:OBI_0000639 .

obo:CL_0000525 a rdfs:Class ;
  rdfs:label "syncytiotrophoblast cell" ;
  rdfs:comment "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002508 a rdfs:Class ;
  rdfs:label "langerin-negative, CD103-negative lymph node dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:OBI_0600044 a rdfs:Class ;
  rdfs:label "lavage"@en ;
  rdfs:comment "A protocol application to separate cells and/or cellular secretions from an anatomical space by the introduction and removal of fluid"@en ;
  rdfs:subClassOf obo:OBI_0600005 , obo:OBI_0600014 .

obo:BFO_0000063 a rdf:Property ;
  rdfs:label "followed by" ;
  rdfs:comment "The assertion P 'followed by' P1 tells us something about Ps in general: that is, it tells us something about what happened later, given what we know about what happened earlier. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be preceded by some instance of P. Note that assertions using this property only are rather weak. Typically we will be interested in stronger relations, for example in the relation 'directly followed by'." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:OBI_0000299 a rdf:Property ;
  rdfs:label "has_specified_output"@en ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
  rdfs:domain obo:OBI_0000011 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 , obo:NGBO_6000380 .

obo:RO_0002501 a rdf:Property ;
  rdfs:label "causal relation between processes" ;
  rdfs:comment "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000003 ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:BFO_0000184 a rdf:Property ;
  rdfs:label "history of"@en ;
  rdfs:comment "[copied from inverse property 'has history'] b has_history c iff c history_of b [XXX-001" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000040 ;
  rdfs:subPropertyOf obo:BFO_0000066 .

obo:OBI_0000417 a rdf:Property ;
  rdfs:label "achieves_planned_objective" ;
  rdfs:comment "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process." ;
  rdfs:domain obo:OBI_0000011 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000293 a rdf:Property ;
  rdfs:label "has_specified_input"@en ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
  rdfs:domain obo:OBI_0000011 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 , obo:NGBO_6000380 .

obo:BFO_0000066 a rdf:Property ;
  rdfs:label "occurs in"@en ;
  rdfs:comment "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000004 .

obo:OBI_0001950 a rdf:Property ;
  rdfs:label "has performer"@en ;
  rdfs:domain obo:OBI_0000011 ;
  rdfs:range obo:BFO_0000002 ;
  rdfs:subPropertyOf obo:RO_0000057 , obo:NGBO_6000380 .

obo:BFO_0000055 a rdf:Property ;
  rdfs:label "realizes"@en ;
  rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
  rdfs:domain obo:BFO_0000015 ;
  rdfs:range obo:BFO_0000017 .

obo:RO_0000057 a rdf:Property ;
  rdfs:label "has_participant" ;
  rdfs:comment "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
  rdfs:domain obo:BFO_0000003 ;
  rdfs:range obo:BFO_0000002 .

obo:NGBO_6000473 a rdfs:Class ;
  rdfs:label "amino acid substitution"@en ;
  rdfs:comment "A data item which represents the substitution of one or more amino acids." ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0001623 a rdfs:Class ;
  rdfs:label "organism identification objective"@en ;
  rdfs:comment "A biological feature identification objective to identify the organism species in a specimen."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:IDO_0000619 a rdfs:Class ;
  rdfs:label "immunosuppressive disposition"@en ;
  rdfs:comment "A disposition whose realization negatively regulates an immune response."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_0001926 a rdfs:Class ;
  rdfs:label "microRNA profiling assay" ;
  rdfs:comment "A transcription profiling assay that quantifies the microRNA species within a biological sample." ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_0000094 a rdfs:Class ;
  rdfs:label "material processing"@en ;
  rdfs:comment "A planned process which results in physical changes in a specified input material"@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0001092 a rdfs:Class ;
  rdfs:label "computer cluster" ;
  rdfs:comment "A group of linked computers, working together closely so that in many respects they form a single computer." ;
  rdfs:subClassOf obo:OBI_0400107 .

obo:CL_0002014 a rdfs:Class ;
  rdfs:label "Kit-negative, Ly-76 high basophilic erythroblast" ;
  rdfs:subClassOf obo:CL_0000549 .

obo:OMIABIS_0000051 a rdfs:Class ;
  rdfs:label "fixed tissue block specimen"@en ;
  rdfs:comment "A fixed tissue specimen that is in block form."@en ;
  rdfs:subClassOf obo:OMIABIS_0000050 .

obo:CL_0000192 a rdfs:Class ;
  rdfs:label "smooth muscle cell" ;
  rdfs:comment "Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (myoblasts, smooth muscle) (MSH)." ;
  rdfs:subClassOf obo:CL_0000187 .

obo:CL_0000055 a rdfs:Class ;
  rdfs:label "blast cell" ;
  rdfs:comment "A precursor cell with a limited number of potential fates." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000268 a rdfs:Class ;
  rdfs:label "organism feature identification objective"@en ;
  rdfs:comment "Organism_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the level of the organism, e.g. height, weight, stage of development, stage of life cycle."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBIB_0000036 a rdfs:Class ;
  rdfs:label "buffy coat specimen"@en ;
  rdfs:comment "A processed specimen which is the output of a density gradient centrifugation of an anticoagulated blood specimen that contains most of the white blood cells and platelets." ;
  rdfs:subClassOf obo:OBI_0000953 .

obo:NGBO_6000204 a rdfs:Class ;
  rdfs:label "16s RNA sequence data"@en ;
  rdfs:comment "RNA sequence data which is about the 16s gene of one or more organisms."@en ;
  rdfs:subClassOf obo:OBIws_0000192 .

obo:OBI_0000655 a rdfs:Class ;
  rdfs:label "blood specimen" ;
  rdfs:comment "a material entity derived from a portion of blood collected from an organism" ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:NGBO_6000395 a rdfs:Class ;
  rdfs:label "target enrichment protocol"@en ;
  rdfs:comment "A protocol which describes the workflow to capture specific regions of interest after library preparation for NGS and has many advantages over whole genome sequencing (WGS)." ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:OBI_0001864 a rdfs:Class ;
  rdfs:label "RNA Annotation and Mapping of Promoters for the Analysis of Gene Expression assay" ;
  rdfs:comment "An transcription profiling assay that identifies transcription start sites (TSS), the quantification of their expression and the characterization of their transcripts using high throughput sequencing." ;
  rdfs:subClassOf obo:OBI_0000424 , obo:OBI_0600047 .

obo:BFO_0000034 a rdfs:Class ;
  rdfs:label "function"@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:CL_0000992 a rdfs:Class ;
  rdfs:label "immature CD11c-low plasmacytoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000989 .

obo:OBI_0000947 a rdfs:Class ;
  rdfs:label "service provider role" ;
  rdfs:comment "is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:BFO_0000017 a rdfs:Class ;
  rdfs:label "realizable entity"@en ;
  rdfs:comment "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:CL_0000598 a rdfs:Class ;
  rdfs:label "pyramidal cell" ;
  rdfs:comment "A projection neuron in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region." ;
  rdfs:subClassOf obo:CL_0000540 .

obo:OBI_0200081 a rdfs:Class ;
  rdfs:label "sequence analysis objective"@en ;
  rdfs:comment "A sequence analysis objective is a data transformation objective which aims to analyse some ordered biological data for sequential patterns."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002580 a rdfs:Class ;
  rdfs:label "aligned sequence data" ;
  rdfs:comment "The results of a sequence alignment." ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0002126 a rdfs:Class ;
  rdfs:label "IHC-stained fixed tissue slide specimen"@en ;
  rdfs:comment "A fixed tissue slide specimen that is the output of immunohistochemistry slide staining."@en ;
  rdfs:subClassOf obo:OMIABIS_0000052 .

<http://semanticscience.org/resource/SIO_001196> a rdfs:Class ;
  rdfs:label "history"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000136> .

obo:OBIB_0000573 a rdfs:Class ;
  rdfs:label "clinical history of clotting disorders" ;
  rdfs:comment "A clinical history in which there is a history of clotting disorders, such as hemophilia, requiring treatment with human-derived clotting factors." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0002351 a rdfs:Class ;
  rdfs:label "progenitor cell of endocrine pancreas" ;
  rdfs:comment "A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_0000060 a rdfs:Class ;
  rdfs:label "PM6 criteria"@en ;
  rdfs:comment "Assumed de novo, but without confirmation of paternity and maternity" ;
  rdfs:subClassOf obo:NGBO_0000065 .

obo:CL_0000961 a rdfs:Class ;
  rdfs:label "Bm1 B cell" ;
  rdfs:subClassOf obo:CL_0000843 .

obo:NGBO_6000472 a rdfs:Class ;
  rdfs:label "data file"@en ;
  rdfs:comment "Any data file as generated by some acquisition computer or console." ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:CL_0000863 a rdfs:Class ;
  rdfs:label "inflammatory macrophage" ;
  rdfs:subClassOf obo:CL_0000861 .

obo:CL_0001002 a rdfs:Class ;
  rdfs:label "mature CD8_alpha-negative CD11b-negative dendritic cell" ;
  rdfs:subClassOf obo:CL_0000998 .

obo:GENO_0000902 a rdfs:Class ;
  rdfs:label "genomic feature location"@en ;
  rdfs:comment "The location of a sequence feature in a genome, defined by its start and end position on some reference genomic coordinate system" ;
  rdfs:subClassOf obo:GENO_0000815 .

obo:SO_0000353 a rdfs:Class ;
  rdfs:label "sequence_assembly" ;
  rdfs:comment "A sequence of nucleotides that has been algorithmically derived from an alignment of two or more different sequences." ;
  rdfs:subClassOf obo:SO_0001248 .

obo:NGBO_6000292 a rdfs:Class ;
  rdfs:label "standard operating procedure version number"@en ;
  rdfs:comment "A version number denotes standard operating procedure" ;
  rdfs:subClassOf obo:IAO_0000129 .

obo:OBIB_0000584 a rdfs:Class ;
  rdfs:label "clinical history of drug abuse" ;
  rdfs:comment "A clinical history in which there is a history of drug abuse." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000128 a rdfs:Class ;
  rdfs:label "sequence clustring"@en ;
  rdfs:comment "A bioinformatics analysis which attempt to group biological sequences that are somehow related" ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:STATO_0000102 a rdf:Property ;
  rdfs:label "executes" ;
  rdfs:comment "relationship between a planned process and the plan specification that it carries out; it is defined as equivalent to the composed relationship (realizes o concretizes)"@en ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:NGBO_6000380 .

<http://www.ebi.ac.uk/efo/EFO_0002534> a rdfs:Class ;
  rdfs:label "fetal blood cell" ;
  rdfs:subClassOf obo:CL_0000081 .

obo:OBI_0001331 a rdfs:Class ;
  rdfs:label "transcription profiling identification objective"@en ;
  rdfs:comment "A molecular feature identification objective that aims to characterize the abundance of transcripts"@en ;
  rdfs:subClassOf obo:OBI_0000131 .

obo:OBIB_0000530 a rdfs:Class ;
  rdfs:label "time since last usage of hormone replacement therapy" ;
  rdfs:comment "A time measurement datum that is the result of measuring the time elapsed since the participant last used hormonally replacement therapy." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0200172 a rdfs:Class ;
  rdfs:label "partitioning objective"@en ;
  rdfs:comment "A partitioning objective is a data transformation objective where the aim is to generate a collection of disjoint non-empty subsets whose union equals a non-empty input set."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:NGBO_6000269 a rdfs:Class ;
  rdfs:label "copy number variation"@en ;
  rdfs:comment "A molecular quality that represent the number of copies of a particular gene varies from one individual to the next (germline mutation)" ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002565 a rdfs:Class ;
  rdfs:label "adapter-sequence trimming" ;
  rdfs:comment "A data transformation in which adapter sequences at the end of a molecular sequence are cut (removed)." ;
  rdfs:subClassOf obo:OBI_0002585 .

obo:OBI_0001110 a rdfs:Class ;
  rdfs:label "real-time PCR machine" ;
  rdfs:comment "An PCR instrument that enables both detection and quantification of one or more specific sequences in a DNA sample." ;
  rdfs:subClassOf obo:OBI_0000989 .

obo:CL_0002455 a rdfs:Class ;
  rdfs:label "CD8_alpha-negative plasmactyoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000989 .

obo:NGBO_6000005 a rdfs:Class ;
  rdfs:label "SAM format"@en ;
  rdfs:comment "A file format which represent a text-based format for storing biological sequences aligned to a reference sequence" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:OBI_0002538 a rdfs:Class ;
  rdfs:label "cerebellum specimen" ;
  rdfs:comment "A specimen that is derived from cerebellum." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000148 a rdfs:Class ;
  rdfs:label "melanocyte" ;
  rdfs:comment "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0200183 a rdfs:Class ;
  rdfs:label "scaling objective"@en ;
  rdfs:comment "is a data transformation objective where all, or some of a data set is adjusted by some data transformation according to some scale, for example a user defined minimum or maximum" ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0000885 a rdfs:Class ;
  rdfs:label "gut-associated lymphoid tissue macrophage" ;
  rdfs:subClassOf obo:CL_0000884 .

obo:OBIB_0000204 a rdfs:Class ;
  rdfs:label "parent specimen ID" ;
  rdfs:comment "A specimen ID denoting a specimen that is used to create a specimen family." ;
  rdfs:subClassOf obo:OBI_0001616 .

obo:CL_0000100 a rdfs:Class ;
  rdfs:label "motor neuron" ;
  rdfs:comment "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." ;
  rdfs:subClassOf obo:CL_0000540 .

obo:BFO_0000145 a rdfs:Class ;
  rdfs:label "relational quality"@en ;
  rdfs:comment "b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])"@en ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:OBI_0000880 a rdfs:Class ;
  rdfs:label "RNA extract" ;
  rdfs:comment "an extract which is the output of an extraction process in which RNA molecules are isolated from a specimen." ;
  rdfs:subClassOf obo:NGBO_6000106 , obo:OBI_0001010 .

obo:CL_0000485 a rdfs:Class ;
  rdfs:label "mucosal type mast cell" ;
  rdfs:subClassOf obo:CL_0000097 .

obo:OBI_0000832 a rdfs:Class ;
  rdfs:label "measurement device" ;
  rdfs:comment "A device in which a measure function inheres." ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:IAO_0000416 a rdfs:Class ;
  rdfs:label "time measurement datum"@en ;
  rdfs:comment "A scalar measurement datum that is the result of measuring a temporal interval"@en ;
  rdfs:subClassOf obo:IAO_0000032 .

obo:CL_0002469 a rdfs:Class ;
  rdfs:label "MHC-II-negative classical monocyte" ;
  rdfs:subClassOf obo:CL_0002395 .

<http://www.ebi.ac.uk/efo/EFO_0002451> a rdfs:Class ;
  rdfs:label "HUVEC cell" ;
  rdfs:comment "A convenient source of human endothelial cells are those that line the large vein in the umbilical cord which is usually discarded together with the placenta after childbirth. The cells can be removed as a fairly pure suspension by mild enzymatic treatment of the vein followed by some mechanical distraction and will grow relatively easily in culture, retaining their differentiated characteristics for several passages." ;
  rdfs:subClassOf obo:CL_0000115 .

obo:OBI_0002516 a rdfs:Class ;
  rdfs:label "brain specimen" ;
  rdfs:comment "A specimen that is derived from brain." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBIB_0000293 a rdfs:Class ;
  rdfs:label "FFPE alcohol stage duration" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration of the alcohol stage in a formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:NGBO_6000229 a rdfs:Class ;
  rdfs:label "functional annotation"@en ;
  rdfs:comment "Functional annotation is a bioinformatics analysis consists of attaching biological information to genomic elements such as: biochemical function, biological function, involved regulation and interactions and expression" ;
  rdfs:subClassOf obo:OBI_0001944 .

obo:CL_0000767 a rdfs:Class ;
  rdfs:label "basophil" ;
  rdfs:comment "Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes." ;
  rdfs:subClassOf obo:CL_0000094 .

<http://www.ebi.ac.uk/efo/EFO_0002661> a rdfs:Class ;
  rdfs:label "dendritic cell-derived intermediate cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

<http://www.obofoundry.org/ro/ro.owl#derives_from> a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:CL_0002526 a rdfs:Class ;
  rdfs:label "CD14-positive dermal dendritic cell" ;
  rdfs:subClassOf obo:CL_0001006 .

obo:CL_0000831 a rdfs:Class ;
  rdfs:label "mast cell progenitor" ;
  rdfs:subClassOf obo:CL_0000839 .

obo:CL_0002476 a rdfs:Class ;
  rdfs:label "bone marrow macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:CL_0002029 a rdfs:Class ;
  rdfs:label "Fc-epsilon RIalpha-low mast cell progenitor" ;
  rdfs:subClassOf obo:CL_0000831 .

obo:NGBO_6000411 a rdfs:Class ;
  rdfs:label "software version number"@en ;
  rdfs:comment "Information about software includes information on software version number." ;
  rdfs:subClassOf obo:NGBO_6000409 .

<http://www.ebi.ac.uk/efo/EFO_1001470> a rdfs:Class ;
  rdfs:label "merkel cell"@en ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000514 a rdfs:Class ;
  rdfs:label "smooth muscle myoblast" ;
  rdfs:comment "A precursor cell destined to differentiate into smooth muscle myocytes." ;
  rdfs:subClassOf obo:CL_0000187 .

obo:OBI_0002549 a rdfs:Class ;
  rdfs:label "ovary specimen" ;
  rdfs:comment "A specimen that is derived from female gonad." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000874 a rdfs:Class ;
  rdfs:label "splenic red pulp macrophage" ;
  rdfs:subClassOf obo:CL_0000871 .

obo:OBI_0001573 a rdfs:Class ;
  rdfs:label "DNA sequence data" ;
  rdfs:comment "A sequence data item that is about the primary structure of DNA" ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0001854 a rdfs:Class ;
  rdfs:label "protein and RNA interaction identification objective"@en ;
  rdfs:comment "A sequence feature identification objective that aims to characterize the interactions between protein and RNA." ;
  rdfs:subClassOf obo:OBI_0000113 .

obo:OBI_0002045 a rdfs:Class ;
  rdfs:label "poly(A)-site sequencing assay" ;
  rdfs:comment "A RNA-seq assay that quantitatively profiles RNA polyadenylation at the transcriptome level." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0000510 a rdfs:Class ;
  rdfs:label "reversed phase column"@en ;
  rdfs:comment "A reversed phase column is a chromatography column in which the mobile phase is more polar than the stationary phase. Its counterpart is the normal phase column."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0002012 a rdfs:Class ;
  rdfs:label "PacBio RS II" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Pacific Biosciences corporation. Built upon single molecule real-time sequencing technology, the machine is optimized for generation with long reads and high consensus accuracy." ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:NGBO_6000306 a rdfs:Class ;
  rdfs:label "likely benign variant"@en ;
  rdfs:comment "A clinical variant interpretation that represents a sequence variant that is previously unreported and is probably not causative of disease" ;
  rdfs:subClassOf obo:NGBO_6000302 .

obo:OBI_0001100 a rdfs:Class ;
  rdfs:label "microcentrifuge" ;
  rdfs:comment "A type of centrifuge that is designed for small tubes (0.2 ml to 2.0 ml), has a compact design, and has a small footprint." ;
  rdfs:subClassOf obo:OBI_0400106 .

obo:NGBO_6000123 a rdfs:Class ;
  rdfs:label "gene expression level analysis"@en ;
  rdfs:comment "A gene expression level analysis is a bioinformatics analysis that compares the RNA expression levels of multiple genes (profiling) and/or multiple samples (screening)" ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:PATO_0015009 a rdfs:Class ;
  rdfs:label "humidity" ;
  rdfs:comment "A quality inhering in air by virtue of the partial pressure exerted by the bearer's water vapour content." ;
  rdfs:subClassOf obo:PATO_0000146 .

obo:OBIB_0000073 a rdfs:Class ;
  rdfs:label "case report form completion SOP" ;
  rdfs:comment "A standard operating procedure for properly and completely filling out a case report form." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:CL_0000047 a rdfs:Class ;
  rdfs:label "neuronal stem cell" ;
  rdfs:comment "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has  the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." ;
  rdfs:subClassOf obo:CL_0000034 .

obo:NGBO_6000382 a rdfs:Class ;
  rdfs:label "bioinformatics analysis software"@en ;
  rdfs:comment "A software designed to extract meaningful information from the mass of molecular biology data" ;
  rdfs:subClassOf obo:IAO_0000010 .

obo:CL_0000091 a rdfs:Class ;
  rdfs:label "Kupffer cell" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:NGBO_0000067 a rdfs:Class ;
  rdfs:label "ACMG supporting classification criteria"@en ;
  rdfs:comment "ACMG guidelines for classification of variants of spporting classification" ;
  rdfs:subClassOf obo:NGBO_6000355 .

obo:NGBO_6000175 a rdfs:Class ;
  rdfs:label "biological database"@en ;
  rdfs:comment "A database which represent libraries of life sciences information, collected from scientific experiments, published literature, high-throughput experiment technology, and computational analysis." ;
  rdfs:subClassOf obo:NGBO_6000248 .

obo:CL_0002458 a rdfs:Class ;
  rdfs:label "langerin-positive dermal dendritic cell" ;
  rdfs:subClassOf obo:CL_0001006 .

obo:OBIB_0000051 a rdfs:Class ;
  rdfs:label "smoking start date"@en ;
  rdfs:comment "A time measurement datum which is the start date of a smoking behavior." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBIB_0000556 a rdfs:Class ;
  rdfs:label "a clinical history of contact with someone with smallpox" ;
  rdfs:comment "A clinical history in which there is a history of contact with someone who recently had smallpox." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0002144 a rdfs:Class ;
  rdfs:label "capillary endothelial cell" ;
  rdfs:comment "An endothelial cell found in capillaries." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000592 a rdfs:Class ;
  rdfs:label "clinical history of Hepatitis C" ;
  rdfs:comment "A clinical history in which there is a history of Hepatitis C infection." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000879 a rdfs:Class ;
  rdfs:label "meningeal macrophage" ;
  rdfs:subClassOf obo:CL_0000878 .

obo:CL_0000071 a rdfs:Class ;
  rdfs:label "blood vessel endothelial cell" ;
  rdfs:comment "The endothelial cells that line the vasculature." ;
  rdfs:subClassOf obo:CL_0000115 .

obo:CL_0002120 a rdfs:Class ;
  rdfs:label "CD24-positive CD38-negative IgG-negative class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0002118 .

obo:CL_0002151 a rdfs:Class ;
  rdfs:label "late promyelocyte" ;
  rdfs:subClassOf obo:CL_0000836 .

obo:CL_0002007 a rdfs:Class ;
  rdfs:label "Kit-low, CD34-positive eosinophil progenitor cell" ;
  rdfs:subClassOf obo:CL_0000611 .

obo:OBI_0002530 a rdfs:Class ;
  rdfs:label "adipose tissue specimen" ;
  rdfs:comment "A specimen that is derived from adipose tissue." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000981 a rdfs:Class ;
  rdfs:label "double negative memory B cell" ;
  rdfs:subClassOf obo:CL_0000787 .

obo:OBI_0001922 a rdfs:Class ;
  rdfs:label "microRNA profiling by high throughput sequencing assay" ;
  rdfs:comment "A microRNA profiling assay that analyzes the microRNA component of the transcriptome using high throughput sequencing technology." ;
  rdfs:subClassOf obo:OBI_0001926 .

obo:PATO_0001985 a rdfs:Class ;
  rdfs:label "frozen" ;
  rdfs:comment "A quality inhering in a bearer by virtue of the bearer's being kept below its freezing point." ;
  rdfs:subClassOf obo:NGBO_6000294 , obo:PATO_0000146 .

obo:NGBO_6000272 a rdfs:Class ;
  rdfs:label "secure file transfer protocol"@en ;
  rdfs:comment "A data transfer protocol is a network protocol that provides file access, file transfer, and file management over any reliable data stream" ;
  rdfs:subClassOf obo:NGBO_6000273 .

obo:OBI_0002023 a rdfs:Class ;
  rdfs:label "Human Genome U133 Plus 2.0 tiling array" ;
  rdfs:comment "A tiling array which is  a comprehensive whole human genome expression array manufactured by the Affymetrix corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 47,000 transcripts and variants." ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:NGBO_6000003 a rdfs:Class ;
  rdfs:label "data file format"@en ;
  rdfs:comment "Information content entity that is a standard way that information is encoded for storage in a computer file." ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:NGBO_6000360 a rdfs:Class ;
  rdfs:label "adapter ligation protocol"@en ;
  rdfs:comment "A protocol which describes the process of attaching synthetic oligonucleotides with known sequences to both or either ends of complementary DNA (cDNA) fragments as a prepration for sequencing"@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:CL_0002018 a rdfs:Class ;
  rdfs:label "CD71-negative, GlyA-positive orthochromatic erythroblast" ;
  rdfs:subClassOf obo:CL_0000552 .

obo:NGBO_6000400 a rdfs:Class ;
  rdfs:label "in-bead tagmentation library prepration"@en ;
  rdfs:comment "A library preparation material processing which uses bead-linked transposomes for a more uniform tagmentation reaction compared to in-solution tagmentation reactions" ;
  rdfs:subClassOf obo:OBI_0000711 .

obo:CL_0002563 a rdfs:Class ;
  rdfs:label "intestinal epithelial cell" ;
  rdfs:comment "An epithelial cell of the intestine. [ GOC:tfm ] " ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000178 a rdfs:Class ;
  rdfs:label "Leydig cell" ;
  rdfs:comment "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002009 a rdfs:Class ;
  rdfs:label "Mouse 3x720K Whole Genome CGH Tiling Array" ;
  rdfs:comment "An autolysis value specification that indicates no apparent autolytic destruction of an organism cells or tissues." ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_0001872 a rdfs:Class ;
  rdfs:label "sequence assembly process"@en ;
  rdfs:comment "A data transformation that assembles two or more individual sequence reads into contiguous sequences (i.e., contigs)." ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:OBI_0002088 a rdfs:Class ;
  rdfs:label "specimen container"@en ;
  rdfs:comment "A container with the function of containing a specimen."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBIB_0000038 a rdf:Property ;
  rdfs:label "has actual load"@en ;
  rdfs:comment "A relation that relates a container to a measurement datum that specifies the actual amount of material in the container." ;
  rdfs:domain obo:OBI_0000967 ;
  rdfs:range obo:IAO_0000109 .

obo:OBIB_0000037 a rdf:Property ;
  rdfs:label "has maximum capacity"@en ;
  rdfs:comment "A relation that relates a container to a measurement datum that specifies the maximum capacity of the container." ;
  rdfs:domain obo:OBI_0000967 ;
  rdfs:range obo:IAO_0000109 .

obo:OBIB_0000200 a rdfs:Class ;
  rdfs:label "receipt and dissection of surgical specimen SOP" ;
  rdfs:comment "A standard operating procedure for the receipt and dissection of surgical tissue in a biobank." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:OBIB_0000272 a rdfs:Class ;
  rdfs:label "specimen transporting organization" ;
  rdfs:comment "A role borne by an organization that is the provider of a specimen that is transported to another organization." ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:BFO_0000030 a rdfs:Class ;
  rdfs:label "object"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:CL_0000773 a rdfs:Class ;
  rdfs:label "eosinophilic metamyelocyte" ;
  rdfs:subClassOf obo:CL_0000772 , obo:CL_0002192 .

obo:OBIB_0000581 a rdfs:Class ;
  rdfs:label "clinical history of an unexplained cough or shortness of breath" ;
  rdfs:comment "A clinical history in which there is are active signs of unexplained persistent cough and/or shortness of breath." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000829 a rdfs:Class ;
  rdfs:label "basophilic myeloblast" ;
  rdfs:subClassOf obo:CL_0000835 .

obo:OBI_0600057 a rdfs:Class ;
  rdfs:label "enzymatic DNA replication"@en ;
  rdfs:comment "the use of enzymes to duplicate DNA molecule any process used to make additional copies of a biomaterial"@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:PATO_0001827 a rdfs:Class ;
  rdfs:label "pseudohermaphrodite" ;
  rdfs:comment "A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of one sex and external sexual characteristics of the other sex." ;
  rdfs:subClassOf obo:PATO_0001894 .

obo:CL_0002191 a rdfs:Class ;
  rdfs:label "granulocytopoietic cell" ;
  rdfs:subClassOf obo:CL_0000839 .

obo:CL_0002107 a rdfs:Class ;
  rdfs:label "IgD-negative CD38-positive IgG memory B cell" ;
  rdfs:subClassOf obo:CL_0002105 .

obo:OMRSE_00000024 a rdfs:Class ;
  rdfs:label "role in human social processes"@en ;
  rdfs:comment "A role inhering in an entity realized by social interactions in human society."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002034 a rdfs:Class ;
  rdfs:label "transcript leader sequencing assay" ;
  rdfs:comment "An RNA-seq assay that combines enzymatic capture of m(7)G-capped mRNA 5' ends with high-throughput sequencing." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:NGBO_6000103 a rdfs:Class ;
  rdfs:label "standard operating procedure actual use duration"@en ;
  rdfs:comment "A one-dimensional temporal region that is a period of an duration of standard operation procedure" ;
  rdfs:subClassOf obo:BFO_0000038 .

obo:OBI_0002130 a rdfs:Class ;
  rdfs:label "Illumina Infinium Omni5Exome-4 Kit"@en ;
  rdfs:comment "An Illumina BeadChip which is an array that interrogates over 4.3 million whole-genome variants for genotyping and copy number variation."@en ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:OBIB_0000552 a rdfs:Class ;
  rdfs:label "clinical history of blood transfusion in foreign country" ;
  rdfs:comment "A clinical history in which there is a history of receiving a blood transfusion while in another country." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NCBITaxon_314146 a rdfs:Class ;
  rdfs:label "Euarchontoglires" ;
  rdfs:subClassOf obo:NCBITaxon_40674 .

obo:OBIB_0000220 a rdfs:Class ;
  rdfs:label "buffered formalin condition" ;
  rdfs:comment "A quality that inheres in buffered formalin by virtue of its usage and processing." ;
  rdfs:subClassOf obo:BFO_0000019 .

<http://semanticscience.org/resource/SIO_001166> a rdfs:Class ;
  rdfs:label "annotation"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000136> .

obo:OBIB_0000257 a rdfs:Class ;
  rdfs:label "name of person processing blood plasma specimen aliquots" ;
  rdfs:comment "A personal name that designates the person who processed a blood specimen to generate aliquots of blood plasma specimens." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0002505 a rdfs:Class ;
  rdfs:label "milk specimen" ;
  rdfs:comment "A specimen that is derived from milk." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:BFO_0000006 a rdfs:Class ;
  rdfs:label "spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:OBI_0001050 a rdfs:Class ;
  rdfs:label "RNA extraction/purification instrument" ;
  rdfs:comment "A device that is used to isolate and collect RNA for subsequent molecular analysis." ;
  rdfs:subClassOf obo:OBI_0001114 .

obo:OBI_0000047 a rdfs:Class ;
  rdfs:label "processed material"@en ;
  rdfs:comment "Is a material entity that is created or changed during material processing."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:CL_0002601 a rdfs:Class ;
  rdfs:label "uterine smooth muscle cell" ;
  rdfs:comment "A smooth muscle cell of the uterus." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002353 a rdfs:Class ;
  rdfs:label "fetal liver hematopoietic progenitor cell" ;
  rdfs:comment "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." ;
  rdfs:subClassOf obo:CL_0002352 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002617 a rdfs:Class ;
  rdfs:label "adipocyte of breast" ;
  rdfs:comment "A fat cell that is part of the breast." ;
  rdfs:subClassOf obo:CL_0000136 .

obo:CL_0000558 a rdfs:Class ;
  rdfs:label "reticulocyte" ;
  rdfs:comment "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." ;
  rdfs:subClassOf obo:CL_0000764 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000595 a rdfs:Class ;
  rdfs:label "clinical history of sarcoidosis" ;
  rdfs:comment "A clinical history in which there is a history of sarcoidosis." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBIB_0000509 a rdfs:Class ;
  rdfs:label "moderate alcohol consumption history" ;
  rdfs:comment "An Alcohol Use History in which alcohol consumption was equal to or less than 2 drinks per day for men and 1 drink or less per day for women." ;
  rdfs:subClassOf obo:NCIT_C81229 .

obo:CL_0000968 a rdfs:Class ;
  rdfs:label "Be cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:CL_0000762 a rdfs:Class ;
  rdfs:label "nucleated thrombocyte" ;
  rdfs:subClassOf obo:CL_0000763 .

obo:NGBO_0000057 a rdfs:Class ;
  rdfs:label "PS4 criteria"@en ;
  rdfs:comment """The prevalence of the variant in affected individuals is significantly
increased compared to the prevalence in controls""" ;
  rdfs:subClassOf obo:NGBO_0000063 .

obo:OBI_0001204 a rdfs:Class ;
  rdfs:label "SNP microarray"@en ;
  rdfs:comment "a DNA microarray used to detect polymorphisms in DNA samples" ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:CL_0000977 a rdfs:Class ;
  rdfs:label "IgG short lived plasma cell" ;
  rdfs:subClassOf obo:CL_0000975 .

obo:CL_0000576 a rdfs:Class ;
  rdfs:label "monocyte" ;
  rdfs:comment "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ;
  rdfs:subClassOf obo:CL_0000766 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000950 a rdfs:Class ;
  rdfs:label "IgE plasmablast" ;
  rdfs:subClassOf obo:CL_0000980 .

obo:NGBO_6000281 a rdfs:Class ;
  rdfs:label "sequencing quality scores"@en ;
  rdfs:comment "Sequencing quality scores measure the probability that a base is called incorrectly." ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:CL_0001024 a rdfs:Class ;
  rdfs:label "CD34-positive, CD38-negative hematopoietic stem cell" ;
  rdfs:subClassOf obo:CL_0000037 .

obo:CL_0000584 a rdfs:Class ;
  rdfs:label "enterocyte" ;
  rdfs:comment "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." ;
  rdfs:subClassOf obo:CL_0002563 .

obo:OBI_0001167 a rdfs:Class ;
  rdfs:label "age measurement datum"@en ;
  rdfs:comment "A time measurement datum that is the result of measurement of age of an organism" ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:PATO_0000128 a rdfs:Class ;
  rdfs:label "weight" ;
  rdfs:comment "A physical quality inhering in a bearer that has mass near a gravitational body." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OBI_0002112 a rdfs:Class ;
  rdfs:label "small RNA sequencing assay" ;
  rdfs:comment "An RNA-seq assay which is targeting small RNA (< 200 bp) sequences such as, but not exclusive to, miRNAs using, for example, small RNA library preparation kits." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0000457 a rdfs:Class ;
  rdfs:label "manufacturing"@en ;
  rdfs:comment "Manufacturing is a process with the intent to produce a processed material which will have a function for future use. A person or organization (having manufacturer role) is a participant in this process"@en ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:NGBO_6000186 a rdfs:Class ;
  rdfs:label "microarray CNV genotypes data"@en ;
  rdfs:comment "A measured expression level measurement datum which represent copy number variation (CNV) obtained by microarray" ;
  rdfs:subClassOf obo:OBI_0000101 .

obo:OBI_0002368 a rdfs:Class ;
  rdfs:label "clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0200168 a rdfs:Class ;
  rdfs:label "correction objective"@en ;
  rdfs:comment "A correction objective is a data transformation objective where the aim is to correct for error, noise or other impairments to the input of the data transformation or derived from the data transformation itself"@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002533 a rdfs:Class ;
  rdfs:label "colon specimen" ;
  rdfs:comment "A specimen that is derived from colon." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0666667 a rdfs:Class ;
  rdfs:label "nucleic acid extraction"@en ;
  rdfs:comment "a material separation to recover the nucleic acid fraction of an input material"@en ;
  rdfs:subClassOf obo:OBI_0302884 .

obo:CL_0000778 a rdfs:Class ;
  rdfs:label "mononuclear osteoclast" ;
  rdfs:subClassOf obo:CL_0000092 .

obo:NGBO_6000270 a rdfs:Class ;
  rdfs:label "copy number alteration"@en ;
  rdfs:comment "A molecular quality that describe changes in copy number that have arisen in somatic tissues." ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:NGBO_6000283 a rdfs:Class ;
  rdfs:label "aliquot"@en ;
  rdfs:comment "A specimen that is divided into separate parts which are typically stored in separate containers as individual samples" ;
  rdfs:subClassOf obo:OBI_0000953 .

obo:OBIB_0000093 a rdfs:Class ;
  rdfs:label "time donor body refrigerated measurement" ;
  rdfs:comment "A time measurement datum that states the duration during which the specimen donor's body was refrigerated." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:ICO_0000088 a rdfs:Class ;
  rdfs:label "participation duration"@en ;
  rdfs:comment "a temporal interval that represent the time of someone (for example the study subject) participating the study or the research."@en ;
  rdfs:subClassOf obo:BFO_0000038 .

obo:CL_0002059 a rdfs:Class ;
  rdfs:label "CD8alpha-positive thymic conventional dendritic cell" ;
  rdfs:subClassOf obo:CL_0000941 .

obo:CL_0000595 a rdfs:Class ;
  rdfs:label "enucleate erythrocyte" ;
  rdfs:subClassOf obo:CL_0000232 .

<http://www.ebi.ac.uk/efo/EFO_0002955> a rdfs:Class ;
  rdfs:label "reproductive system cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000816 a rdfs:Class ;
  rdfs:label "immature B cell" ;
  rdfs:comment "An immature B cell is a precursor B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." ;
  rdfs:subClassOf obo:CL_0000817 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:PATO_0001018 a rdfs:Class ;
  rdfs:label "physical quality" ;
  rdfs:comment "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:OBIB_0000567 a rdfs:Class ;
  rdfs:label "clinical history of exposure to toxins" ;
  rdfs:comment "A clinical history in which there is a history of exposure to toxic substances that may have led to chronic conditions." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:BTO_0000152 a rdfs:Class ;
  rdfs:label "infected cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000349 a rdfs:Class ;
  rdfs:label "extraembryonic cell" ;
  rdfs:comment "A cell which is part of an extraembryonic structure associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000880 a rdfs:Class ;
  rdfs:label "choroid-plexus macrophage" ;
  rdfs:subClassOf obo:CL_0000878 .

obo:OBI_0000835 a rdfs:Class ;
  rdfs:label "manufacturer" ;
  rdfs:comment "A person or organization that has a manufacturer role" ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0400106 a rdfs:Class ;
  rdfs:label "centrifuge"@en ;
  rdfs:comment "A device with a rapidly rotating container that applies centrifugal force to its contents" ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:CL_0002511 a rdfs:Class ;
  rdfs:label "CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell" ;
  rdfs:subClassOf obo:CL_0002508 .

obo:OBI_0400045 a rdfs:Class ;
  rdfs:label "fluid pressure regulator"@en ;
  rdfs:comment "Part of the fluidic subsystem. The fluid pressure regulator maintains constant pressure within the sheath and or sample lines by filling the lines with enough gas to push the fluid at the desired rate. The gas is usually air, and less frequently nitrogen. In the sheath line, the gas is pushed into the sheath tank. In the sample line the gas is pushed into the collection tube. Fluid pressure regulators maintain great enough pressure to push sample fluid out of the tube and sheath fluid out of the sheath tank."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:CL_0002361 a rdfs:Class ;
  rdfs:label "primitive erythroid progenitor" ;
  rdfs:subClassOf obo:CL_0002417 .

obo:CL_1000497 a rdfs:Class ;
  rdfs:label "kidney cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002032 a rdfs:Class ;
  rdfs:label "hematopoietic oligopotent progenitor cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000413 a rdfs:Class ;
  rdfs:label "name of person in gross room receiving OR specimen" ;
  rdfs:comment "A personal name that designates the person who received a specimen in a pathology gross room from an associated operating room (OR)." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001944 a rdfs:Class ;
  rdfs:label "sequence annotation"@en ;
  rdfs:comment "A sequence annotation bioinformatics analysis that identifies and reports sequence features (e.g. protein coding regions) in sequence data."@en ;
  rdfs:subClassOf obo:NGBO_6000122 , obo:OBI_0200187 .

obo:IAO_0000132 a rdfs:Class ;
  rdfs:label "lot number"@en ;
  rdfs:comment "A lot number is an information content entity which is an identical sequence of character borne by part of manufactured product or its packaging for each instances of a product class in a discrete batch of an item. Lot numbers are usually assigned to each separate production run of an item. Manufacturing as a lot might be due to a variety of reasons, for example,  a single process during which many individuals are made from the same portion of source material. Lot numbers can be encoded in a pattern  of other information objects, such as bar codes, numerals, or patterns of dots."@en ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:OBIB_0000250 a rdfs:Class ;
  rdfs:label "conical centrifuge tube identifier" ;
  rdfs:comment "An identifier that specifically identifies a particular conical centrifuge tube." ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:OBI_0002377 a rdfs:Class ;
  rdfs:label "mother clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female parent." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:CL_0002122 a rdfs:Class ;
  rdfs:label "B220-positive CD38-positive IgG-negative class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0002119 .

obo:OBIB_0000342 a rdfs:Class ;
  rdfs:label "manual FFPE tissue section H&E staining" ;
  rdfs:comment "A planned process involving the manual performance of the FFPE tissue section H&E staining protocol." ;
  rdfs:subClassOf obo:OMIABIS_0000911 .

obo:OBI_0001114 a rdfs:Class ;
  rdfs:label "nucleic acid extraction/purification instrument" ;
  rdfs:comment "A device that is used to isolate and collect nucleic acids (DNA or RNA) for subsequent molecular analysis." ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0302884 a rdfs:Class ;
  rdfs:label "extraction"@en ;
  rdfs:comment "A material separation in which a desired component of an input material is separated from the remainder" ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:CL_0002003 a rdfs:Class ;
  rdfs:label "CD34-positive, GlyA-negative erythroid progenitor cell" ;
  rdfs:subClassOf obo:CL_0000038 .

obo:NGBO_6000271 a rdfs:Class ;
  rdfs:label "secure file transfer process"@en ;
  rdfs:comment "Secure file transfer is a planned process that represent data sharing via a secure, reliable delivery method. It is used to safeguard proprietary and personal data in transit and at rest. Most secure file sharing methods use standard protocols, including: Secure File Transfer Protocol (SFTP)" ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBIB_0000320 a rdfs:Class ;
  rdfs:label "microtome blade age" ;
  rdfs:comment "An age that inheres in a microtome blade." ;
  rdfs:subClassOf obo:PATO_0000011 .

obo:NGBO_6000276 a rdfs:Class ;
  rdfs:label "library preparation protocol"@en ;
  rdfs:comment "A protocol plan specification which describes the process of generating a collection of DNA fragments for sequencing" ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:CL_0002364 a rdfs:Class ;
  rdfs:label "cortical thymic epithelial cell" ;
  rdfs:comment "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells. [ PMID:18403190 GOC:tfm ] " ;
  rdfs:subClassOf obo:CL_0000066 .

obo:OBIB_0000408 a rdfs:Class ;
  rdfs:label "name of reviewing pathologist at organization conducting specimen collection" ;
  rdfs:comment "A personal name that designates the person who served as the pathologist reviewing a specimen slide at an organization conducting specimen collection from organisms." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:NGBO_6000237 a rdfs:Class ;
  rdfs:label "DNA library"@en ;
  rdfs:comment "A process material which contains DNA fragments that represent the entire genome of an organism."@en ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:CL_0000065 a rdfs:Class ;
  rdfs:label "ependymal cell" ;
  rdfs:comment "A neurectoderm derived cell that lines the neural lumen. [ JB:jb GOC:tfm PMID:9550134 ]" ;
  rdfs:subClassOf obo:CL_0000066 .

obo:NGBO_0000056 a rdfs:Class ;
  rdfs:label "PS2 criteria"@en ;
  rdfs:comment """De novo (both maternity and paternity confirmed) in a patient with the
disease and no family history""" ;
  rdfs:subClassOf obo:NGBO_0000063 .

obo:OBI_0002484 a rdfs:Class ;
  rdfs:label "star algorithm"@en ;
  rdfs:comment "A reference genome transcriptome alignment algorithm that is a standalone RNA-seq alignment algorithm that uses uncompressed suffix arrays and a mapping algorithm similar to those used in large-scale genome alignment tools to align RNA-seq reads to a genomic reference."@en ;
  rdfs:subClassOf obo:OBI_0002478 .

obo:OBI_0200157 a rdfs:Class ;
  rdfs:label "data vector reduction objective"@en ;
  rdfs:comment "Data vector reduction is a data transformation objective in which k m-dimensional input vectors are reduced to j m-dimensional output vectors, where j is smaller than k."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:NGBO_6000248 a rdfs:Class ;
  rdfs:label "database"@en ;
  rdfs:comment "A database is an information content entity that describe a structured set of data held in a computer, especially one that is accessible in various ways."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:CL_0000845 a rdfs:Class ;
  rdfs:label "marginal zone B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:OBIB_0000360 a rdfs:Class ;
  rdfs:label "collection packet component ID" ;
  rdfs:comment "An identifier that specifically identifies a particular component of a collection packet." ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:OBI_0000713 a rdfs:Class ;
  rdfs:label "GenePattern software" ;
  rdfs:comment "a software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks." ;
  rdfs:subClassOf obo:IAO_0000010 .

<http://semanticscience.org/resource/SIO_000184> a rdfs:Class ;
  rdfs:label "legal name"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000183> .

obo:BFO_0000029 a rdfs:Class ;
  rdfs:label "site"@en ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:CL_0002043 a rdfs:Class ;
  rdfs:label "CD34-positive, CD38-negative multipotent progenitor cell" ;
  rdfs:subClassOf obo:CL_0000837 .

obo:CL_0000346 a rdfs:Class ;
  rdfs:label "hair follicle dermal papilla cell"@en ;
  rdfs:comment "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

<http://semanticscience.org/resource/SIO_010060> a rdfs:Class ;
  rdfs:label "family history"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_001196> .

obo:IAO_0000593 a rdfs:Class ;
  rdfs:label "software library"@en ;
  rdfs:comment "A software library is software composed of a collection of software modules and/or software methods in a form that can be statically or dynamically linked to some software application."@en ;
  rdfs:subClassOf obo:IAO_0000010 .

<http://www.ebi.ac.uk/efo/EFO_1000615> a rdfs:Class ;
  rdfs:label "utering smooth muscle cell"@en ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000723 a rdfs:Class ;
  rdfs:label "DNA sequencing by ligation assay" ;
  rdfs:comment "A DNA sequencing assay that performs chain extension during the sequencing reaction step using DNA ligase" ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:CL_0002000 a rdfs:Class ;
  rdfs:label "Kit-positive erythroid progenitor cell" ;
  rdfs:subClassOf obo:CL_0000038 .

obo:NGBO_6000418 a rdfs:Class ;
  rdfs:label "data file description"@en ;
  rdfs:comment "A description of the file that contain raw data generated by a measurement device." ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000136> .

obo:OBIB_0000585 a rdfs:Class ;
  rdfs:label "clinical history of Severe Acute Respiratory Syndrome" ;
  rdfs:comment "A clinical history in which there is a history of a Severe Acute Respiratory Syndrome (SARS) diagnosis." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000282 a rdfs:Class ;
  rdfs:label "HUGO gene nomenclature committee gene name"@en ;
  rdfs:comment "A biological database that contains genes nomenclature created by the HUGO Gene Nomenclature Committee (HGNC) that sets the standards for human gene nomenclature." ;
  rdfs:subClassOf obo:NGBO_6000175 .

obo:OBI_0000387 a rdfs:Class ;
  rdfs:label "cool function"@en ;
  rdfs:comment "A cool function is a function to decrease the internal kinetic energy of a material below the initial kinetic energy of that type of material."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:CL_0000843 a rdfs:Class ;
  rdfs:label "follicular B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:OBI_0200187 a rdfs:Class ;
  rdfs:label "sequence analysis data transformation"@en ;
  rdfs:comment "A sequence analysis data transformation is a data transformation that has objective sequence analysis and has the aim of analysing ordered biological data for sequential patterns."@en ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:OBIB_0000349 a rdfs:Class ;
  rdfs:label "specimen randomization key ID" ;
  rdfs:comment "A specimen barcode associated with the specific chart (key) used to randomly assign specimens to one of several distinct experimental protocols." ;
  rdfs:subClassOf obo:FLU_0001019 .

obo:OBIB_0000513 a rdfs:Class ;
  rdfs:label "current smoker history" ;
  rdfs:comment "A Smoking History in which there is current smoking either on a daily or non-daily basis." ;
  rdfs:subClassOf obo:NCIT_C29719 .

obo:OBI_0000968 a rdfs:Class ;
  rdfs:label "device" ;
  rdfs:comment "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent." ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:OBI_0002142 a rdfs:Class ;
  rdfs:label "Nanostring nCounter miRNA expression assay" ;
  rdfs:comment "A microRNA profiling assay using digital molecular barcoding technology to quantify target microRNA molecules without the need for amplification." ;
  rdfs:subClassOf obo:OBI_0001926 .

obo:OBI_0002523 a rdfs:Class ;
  rdfs:label "breast specimen" ;
  rdfs:comment "A specimen that is derived from breast. " ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBIB_0000300 a rdfs:Class ;
  rdfs:label "adherence of duration in clearing agent to FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether the duration in clearing agent followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:BTO_0002844 a rdfs:Class ;
  rdfs:label "breast invasive ductal carcinoma cell" ;
  rdfs:comment "Infiltrating ductal carcinoma is one of several recognized specific patterns of cancer of the breast. It is so named because it begins in the cells forming the ducts of the breast. It is the most common form of breast cancer, comprising 65-85% of all cases." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0005934> .

obo:OBI_0000734 a rdfs:Class ;
  rdfs:label "DNA sequencing by synthesis assay" ;
  rdfs:comment "A DNA sequencing assay that relies on DNA polymerase activity to perform chain extension during the sequencing reaction step." ;
  rdfs:subClassOf obo:OBI_0000626 .

<http://semanticscience.org/resource/SIO_000651> a rdfs:Class ;
  rdfs:label "textual entity"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000079> .

obo:CL_0002470 a rdfs:Class ;
  rdfs:label "MHC-II-positive classical monocyte" ;
  rdfs:subClassOf obo:CL_0002395 .

obo:OBI_0002541 a rdfs:Class ;
  rdfs:label "spleen specimen" ;
  rdfs:comment "A specimen that is derived from spleen." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0600036 a rdfs:Class ;
  rdfs:label "establishing cell culture" ;
  rdfs:comment "a process through which a new type of cell culture or cell line is created, either through the isolation and culture of one or more cells from a fresh source, or the deliberate experimental modification of an existing cell culture (e.g passaging a primary culture to become a secondary culture or line, or the immortalization or stable genetic modification of an existing culture or line)." ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:CL_0000151 a rdfs:Class ;
  rdfs:label "secretory cell" ;
  rdfs:comment "A cell that specializes in controlled release of one or more substances." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000097 a rdfs:Class ;
  rdfs:label "mast cell" ;
  rdfs:subClassOf obo:CL_0000766 .

obo:OBI_0002384 a rdfs:Class ;
  rdfs:label "niece clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female child of a sibling." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0002537 a rdfs:Class ;
  rdfs:label "thyroid gland specimen" ;
  rdfs:comment "A specimen that is derived from thyroid gland." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000684 a rdfs:Class ;
  rdfs:label "specimen collection objective" ;
  rdfs:comment "A objective specification to obtain a material entity for potential use as an input during an investigation." ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:NGBO_6000419 a rdfs:Class ;
  rdfs:label "assay execution note"@en ;
  rdfs:comment "A document part of relevant notes or instructions regarding data generation assay execution" ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:OBI_0001108 a rdfs:Class ;
  rdfs:label "nucleic acid sequencer" ;
  rdfs:comment "An device that is used to determine the order of nucleotides in nucleic acid sequences." ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBIB_0000294 a rdfs:Class ;
  rdfs:label "adherence of dehydration process duration to FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether duration of the dehydration process followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:NGBO_6000439 a rdfs:Class ;
  rdfs:label "detected gene mutation"@en ;
  rdfs:comment "A conclusion based on data about a permanent change in the DNA sequence that makes up a gene" ;
  rdfs:subClassOf obo:OBI_0001909 .

obo:OBI_0000124 a rdf:Property ;
  rdfs:label "is_supported_by_data" ;
  rdfs:comment "The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process" ;
  rdfs:range obo:IAO_0000027 .

obo:OBI_0000312 a rdf:Property ;
  rdfs:label "is_specified_output_of" ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
  rdfs:domain obo:BFO_0000002 ;
  rdfs:range obo:OBI_0000011 ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:OBI_0002501 a rdfs:Class ;
  rdfs:label "bile specimen" ;
  rdfs:comment "A specimen that is derived from bile." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:NGBO_6000298 a rdfs:Class ;
  rdfs:label "specimen destruction assay"@en ;
  rdfs:comment "A planned process with the objective to destroy an entire collection or specific specimen." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0001113 a rdfs:Class ;
  rdfs:label "microplate washer" ;
  rdfs:comment "A device that is used to wash immunoassays in microwell strips and plates with professional accuracy. WHAT IS PROFESSIONAL ACCURACY??" ;
  rdfs:subClassOf obo:OBI_0000968 .

<http://www.ebi.ac.uk/efo/EFO_0005293> a rdfs:Class ;
  rdfs:label "B-lymphoblast" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000572> .

obo:OBIB_0000547 a rdfs:Class ;
  rdfs:label "clinical history of positive blood cultures" ;
  rdfs:comment "A clinical history in which there is a history of positive blood cultures." ;
  rdfs:subClassOf obo:OGMS_0000015 .

<http://semanticscience.org/resource/SIO_000026> a rdfs:Class ;
  rdfs:label "object quality"@en ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:CL_0000453 a rdfs:Class ;
  rdfs:label "Langerhans cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:OMIABIS_0000094 a rdfs:Class ;
  rdfs:label "sample collection or study contact role"@en ;
  rdfs:subClassOf obo:OMIABIS_0000012 .

obo:OBI_0000453 a rdfs:Class ;
  rdfs:label "measure function"@en ;
  rdfs:comment "Measure function is a function that is borne by a processed material  and realized in a process in which information about some entity is expressed relative to some reference."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OMIABIS_0001047 a rdfs:Class ;
  rdfs:label "case ID"@en ;
  rdfs:comment "An identifier that refers to a specimen donor who is participating in specimen collection process for tissue procurement purposes and is usually assigned at the time of donor procurement."@en ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:CL_0000586 a rdfs:Class ;
  rdfs:label "germ cell" ;
  rdfs:comment "The reproductive cell in multicellular organisms." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000558 a rdfs:Class ;
  rdfs:label "clinical history of cancer at death" ;
  rdfs:comment "A clinical history in which there is a current diagnosis of cancer at death." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000442 a rdfs:Class ;
  rdfs:label "follicular dendritic cell" ;
  rdfs:comment "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000264 a rdfs:Class ;
  rdfs:label "validation of known variant assay"@en ;
  rdfs:comment "An assay which represent the process of targeting detected known disease causing genetic variant for validation purposes" ;
  rdfs:subClassOf obo:OBI_0000070 .

obo:OBI_0000678 a rdfs:Class ;
  rdfs:label "portioning objective" ;
  rdfs:comment "A material separation objective aiming to separate material into multiple portions, each of which contains a similar composition of the input material." ;
  rdfs:subClassOf obo:OBI_0000639 .

obo:NGBO_6000125 a rdfs:Class ;
  rdfs:label "variant classification assay"@en ;
  rdfs:comment "A genetic variation analysis which assign a formal classification to a detected genetic variant." ;
  rdfs:subClassOf obo:NGBO_6000261 .

obo:CL_0000966 a rdfs:Class ;
  rdfs:label "Bm4 B cell" ;
  rdfs:subClassOf obo:CL_0000844 .

obo:OBIB_0000222 a rdfs:Class ;
  rdfs:label "blood specimen collection and processing SOP" ;
  rdfs:comment "A standard operating procedure for collection and processing of blood specimens." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:NGBO_6000219 a rdfs:Class ;
  rdfs:label "pairwise sequence alignment"@en ;
  rdfs:comment "A sequence alignment bioinformatics analysis which identify regions of similarity that may indicate functional, structural and/or evolutionary relationships between two biological sequences (protein or nucleic acid)" ;
  rdfs:subClassOf obo:OBI_0002567 .

obo:NGBO_6000083 a rdfs:Class ;
  rdfs:label "information about cloud storage bucket"@en ;
  rdfs:comment "Information about data storage location information content entity which represent information about  the basic containers that hold your data in cloud storage"@en ;
  rdfs:subClassOf obo:NGBO_6000399 .

obo:CL_0002357 a rdfs:Class ;
  rdfs:label "fetal derived definitive erythrocyte" ;
  rdfs:subClassOf obo:CL_0000595 .

obo:OBI_0002191 a rdfs:Class ;
  rdfs:label "courier tracking number"@en ;
  rdfs:comment "A centrally registered identifier symbol assigned by a courier organization in order to track the delivery of an item." ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0000839 a rdfs:Class ;
  rdfs:label "labeled oligonucleotide" ;
  rdfs:comment "a labeled oligonucleotide is a short nucleic acid which underwent a labeling process resulting in a radioactive isotope such as P32 or P33 added to its backbone for instance by end labeling with polynucleotide kinase which added radiolabeled ATP to the 5' end of oligonucleotide" ;
  rdfs:subClassOf obo:OBI_0001936 .

obo:BTO_0000426 a rdfs:Class ;
  rdfs:label "erythroleukemia cell" ;
  rdfs:comment """
Cancer cell of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow.
""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0005934> .

obo:BFO_0000038 a rdfs:Class ;
  rdfs:label "one-dimensional temporal region"@en ;
  rdfs:subClassOf obo:BFO_0000008 .

obo:CL_0002022 a rdfs:Class ;
  rdfs:label "Ly-76 high positive erythrocyte" ;
  rdfs:subClassOf obo:CL_0000595 .

obo:OBI_0001177 a rdfs:Class ;
  rdfs:label "RNA sequencing assay" ;
  rdfs:comment "An assay that determines the sequence of an RNA molecule." ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:OBIB_0000477 a rdfs:Class ;
  rdfs:label "name of person screening specimen donors" ;
  rdfs:comment "A personal name that designates who performed the screening of a potential specimen donor for a research study." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:IAO_0000314 a rdfs:Class ;
  rdfs:label "document part"@en ;
  rdfs:comment "an information content entity that is part of a document"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0002373 a rdfs:Class ;
  rdfs:label "aunt clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in the female sibling of a parent." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0000702 a rdfs:Class ;
  rdfs:label "454 Genome Sequencer FLX" ;
  rdfs:comment """is a DNA sequencer which is manufactured by 454 Life Science Corporation and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are
controlled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information.""" ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:CL_0000944 a rdfs:Class ;
  rdfs:label "Be2 cell" ;
  rdfs:subClassOf obo:CL_0000968 .

obo:NGBO_6000099 a rdfs:Class ;
  rdfs:label "insulated shipping container"@en ;
  rdfs:comment "A container which used to ship temperature sensitive products such as foods, pharmaceuticals, organs, blood, biologic materials, and chemicals. They are used as part of a cold chain to help maintain product freshness and efficacy." ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0001893 a rdfs:Class ;
  rdfs:label "organization of specimen collector"@en ;
  rdfs:comment "An organization that is the affiliation of the person collecting the specimen" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0001688 a rdf:Property ;
  rdfs:label "has organization member"@en ;
  rdfs:comment "Relating an organization to a legal person or organization." ;
  rdfs:domain obo:OBI_0000245 ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0002378 a rdfs:Class ;
  rdfs:label "sister clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female sibling." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:PATO_0001241 a rdfs:Class ;
  rdfs:label "physical object quality" ;
  rdfs:comment "A quality which inheres in a continuant." ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:CL_0001006 a rdfs:Class ;
  rdfs:label "dermal dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:CL_0000868 a rdfs:Class ;
  rdfs:label "lymph node macrophage" ;
  rdfs:subClassOf obo:CL_0000867 .

obo:CL_0000996 a rdfs:Class ;
  rdfs:label "mature CD11c-negative plasmacytoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000991 .

obo:IAO_0000178 a rdfs:Class ;
  rdfs:label "material information bearer"@en ;
  rdfs:comment "A material entity in which a concretization of an information content entity inheres."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:NGBO_6000408 a rdfs:Class ;
  rdfs:label "input data file"@en ;
  rdfs:comment "A data file which contain the input for data transformation process" ;
  rdfs:subClassOf obo:NGBO_6000472 .

obo:OBI_0002028 a rdfs:Class ;
  rdfs:label "SAGE ditag library preparation"@en ;
  rdfs:comment """A library preparation in which tags identifiying transcripts are created, ligated to form ditags, amplified, concatemerized and ligated into a vector to create a library.
""" ;
  rdfs:subClassOf obo:OBI_0000711 .

obo:OBI_0000438 a rdfs:Class ;
  rdfs:label "DNA sequence variation detection assay" ;
  rdfs:comment "An assay that measures changes (expansion, amplification, deletion, mutation) in the sequence of a DNA molecule." ;
  rdfs:subClassOf obo:OBI_0200187 .

<http://semanticscience.org/resource/SIO_000115> a rdfs:Class ;
  rdfs:label "identifier"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000179> , obo:IAO_0000028 .

obo:OBIB_0000589 a rdfs:Class ;
  rdfs:label "clinical history of gonorrhea" ;
  rdfs:comment "A clinical history in which there is a history of active gonorrhea infection or treatment for gonorrhea in the recent past." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000834 a rdfs:Class ;
  rdfs:label "neutrophil progenitor cell" ;
  rdfs:subClassOf obo:CL_0002191 .

obo:OBIB_0000603 a rdfs:Class ;
  rdfs:label "clinical history of Amyotrophic Lateral Sclerosis" ;
  rdfs:comment "A clinical history in which there is a history of Amyotrophic Lateral Sclerosis (ALS)" ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000407 a rdfs:Class ;
  rdfs:label "output data file"@en ;
  rdfs:comment "A data file which contain the output of data transformation process" ;
  rdfs:subClassOf obo:NGBO_6000472 .

obo:CL_0000839 a rdfs:Class ;
  rdfs:label "myeloid lineage restricted progenitor cell" ;
  rdfs:comment "A progenitor cell of any myeloid lineage, potentially multipotent." ;
  rdfs:subClassOf obo:CL_0002031 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OMIABIS_0000057 a rdfs:Class ;
  rdfs:label "microdissected specimen"@en ;
  rdfs:comment "A specimen that has been procured from a histology slide under direct microscopic visualization."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0000113 a rdfs:Class ;
  rdfs:label "sequence feature identification objective"@en ;
  rdfs:comment "Sequence_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features exhibited at the level of a macromolecular sequence, e.g. nucleic acid, protein, polysaccharide."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:NGBO_6000399 a rdfs:Class ;
  rdfs:label "information about data storage location"@en ;
  rdfs:comment "An information content entity that is about the location of data storage" ;
  rdfs:subClassOf obo:IAO_0000030 , obo:NGBO_6000385 .

obo:CL_0001014 a rdfs:Class ;
  rdfs:label "CD1a-positive Langerhans cell" ;
  rdfs:subClassOf obo:CL_0000453 .

obo:OBIB_0000385 a rdfs:Class ;
  rdfs:label "specimen image ID" ;
  rdfs:comment "An identifier that specifically identifies a particular specimen image." ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:CL_0000700 a rdfs:Class ;
  rdfs:label "dopaminergic neuron" ;
  rdfs:comment "A neuron that releases dopamine as a neurotransmitter." ;
  rdfs:subClassOf obo:CL_0000540 .

obo:OBIB_0000072 a rdfs:Class ;
  rdfs:label "tissue procurement SOP" ;
  rdfs:comment "A standard operating procedure for collecting specimens from organism." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:CL_0002509 a rdfs:Class ;
  rdfs:label "CD103-positive, langerin-positive lymph node dendritic cell" ;
  rdfs:subClassOf obo:CL_0002507 .

obo:NGBO_0000064 a rdfs:Class ;
  rdfs:label "PS3 criteria"@en ;
  rdfs:comment """Well-established in vitro or in vivo functional studies supportive of a
damaging effect on the gene or gene product""" ;
  rdfs:subClassOf obo:NGBO_0000063 .

obo:OBI_0002552 a rdfs:Class ;
  rdfs:label "testis specimen" ;
  rdfs:comment "A specimen that is derived from testis." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000162 a rdfs:Class ;
  rdfs:label "parietal cell" ;
  rdfs:comment "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." ;
  rdfs:subClassOf obo:CL_0000151 .

<http://www.ebi.ac.uk/efo/EFO_0002433> a rdfs:Class ;
  rdfs:label "cumulus-oocyte complex" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000344 a rdfs:Class ;
  rdfs:label "manual FFPE tissue section H&E cover slipping" ;
  rdfs:comment "A planned process involving the manual performance of the FFPE tissue section H&E cover slip protocol." ;
  rdfs:subClassOf obo:OMIABIS_0000911 .

obo:IAO_0000129 a rdfs:Class ;
  rdfs:label "version number"@en ;
  rdfs:comment "A version number is an information content entity which is a sequence of characters borne by part of each of a class of manufactured products or its packaging and indicates its order within a set of other products having the same name."@en ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:OBI_0002400 a rdfs:Class ;
  rdfs:label "neither hysterectomy nor oophorectomy history" ;
  rdfs:comment "A gynecologic surgery history in which a woman has not had either a hysterectomy or an oophorectomy." ;
  rdfs:subClassOf obo:OBI_0002397 .

obo:CL_0000832 a rdfs:Class ;
  rdfs:label "eosinophilic myeloblast" ;
  rdfs:subClassOf obo:CL_0000835 .

obo:CL_0002118 a rdfs:Class ;
  rdfs:label "CD38-negative IgG-negative class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0002117 .

obo:OBI_0000584 a rdfs:Class ;
  rdfs:label "anion exchange column"@en ;
  rdfs:comment "An anion exchange column is a chromatography column that is used in anion exchange chromatography and which enables the separation of anion mixtures."@en ;
  rdfs:subClassOf obo:OBI_0000560 .

obo:CL_0002551 a rdfs:Class ;
  rdfs:label "fibroblast of dermis"@en ;
  rdfs:comment "fibroblast that is part of dermis" ;
  rdfs:subClassOf obo:CL_0000057 .

obo:NGBO_6000365 a rdfs:Class ;
  rdfs:label "data anonymization protocol"@en ;
  rdfs:comment "A protocol plan specification which describes the process of  reducing the likelihood that the data can identify an individual."@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:CL_0000972 a rdfs:Class ;
  rdfs:label "class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0000787 .

obo:OBIB_0000292 a rdfs:Class ;
  rdfs:label "adherence of alcohol stage duration to FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether duration of the alcohol stage followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:CL_0002402 a rdfs:Class ;
  rdfs:label "Peyer's patch B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:PO_0025606 a rdfs:Class ;
  rdfs:label "native plant cell" ;
  rdfs:comment "A plant cell (PO:0009002) that is either part of a multicellular whole plant (PO:0000003) 'in vivo' or a unicellular organism 'in natura' (i.e. part of a natural environment)." ;
  rdfs:subClassOf obo:PO_0009002 .

obo:OBIB_0000054 a rdfs:Class ;
  rdfs:label "smoking end date"@en ;
  rdfs:comment "A time measurement datum which is the end date of a smoking behavior." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0000129 a rdfs:Class ;
  rdfs:label "microglial cell" ;
  rdfs:comment "A central nervous system macrophage found in the parenchyma of the central nervous system." ;
  rdfs:subClassOf obo:CL_0000878 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000738 a rdfs:Class ;
  rdfs:label "leukocyte" ;
  rdfs:comment "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

<http://www.w3.org/2006/vcard/ns#Address> a rdfs:Class ;
  rdfs:label "address"@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:OMIABIS_0000005 a rdfs:Class ;
  rdfs:label "biobank idenfier with ISO 3166-1 alpha-2 code"@en ;
  rdfs:comment "A biobank identifier that has an ISO 3166-1 alpha-2 code as a part."@en ;
  rdfs:subClassOf obo:OMIABIS_0000003 .

obo:OBI_0000450 a rdfs:Class ;
  rdfs:label "regulatory agency"@en ;
  rdfs:comment "A regulatory agency is a organization that has responsibility over or for  the legislation (acts and regulations) for a given sector of the government."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:SO_0001248 a rdfs:Class ;
  rdfs:label "assembly" ;
  rdfs:comment "A region of the genome of known length that is composed by ordering and aligning two or more different regions." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:CL_0000547 a rdfs:Class ;
  rdfs:label "proerythroblast" ;
  rdfs:comment "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells." ;
  rdfs:subClassOf obo:CL_0000764 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000043 a rdfs:Class ;
  rdfs:label "mature basophil" ;
  rdfs:subClassOf obo:CL_0000767 .

obo:OBI_0001859 a rdfs:Class ;
  rdfs:label "formaldehyde-assisted isolation of regulatory elements assay" ;
  rdfs:comment "An assay to determine the sequences of those DNA regions in the genome associated with regulatory activity." ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:BFO_0000051 a rdf:Property ;
  rdfs:label "has part"@en ;
  rdfs:comment "a core relation that holds between a whole and its part"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:CL_0000820 a rdfs:Class ;
  rdfs:label "B-1a B cell" ;
  rdfs:subClassOf obo:CL_0000819 .

obo:BFO_0000141 a rdfs:Class ;
  rdfs:label "immaterial entity"@en ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:OBI_0002007 a rdfs:Class ;
  rdfs:label "SOLiD 3 Plus System" ;
  rdfs:comment "A DNA sequencer which is manufacted by the Applied Biosystems corporation. Built upon SOLiD sequencing technology, the machine generates greater than 1 billion mappable reads per run." ;
  rdfs:subClassOf obo:OBI_0000696 .

obo:NGBO_6000106 a rdfs:Class ;
  rdfs:label "specimen derivative"@en ;
  rdfs:comment "A specimen which is a recognizable part or product taken from specimen" ;
  rdfs:subClassOf obo:OBI_0000047 , obo:OBI_0100051 .

obo:IAO_0000641 a rdfs:Class ;
  rdfs:label "requirements section"@en ;
  rdfs:comment "A part of a document about a resource described in the document, e.g. software, that describes the requirements necessary to use the resource, e.g. operating systems, hardware, etc. in the case of a software resource."@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:CL_0000881 a rdfs:Class ;
  rdfs:label "perivascular macrophage" ;
  rdfs:subClassOf obo:CL_0000878 .

obo:OBIB_0000578 a rdfs:Class ;
  rdfs:label "clinical history of blue or purple spots on skin or mucous membranes" ;
  rdfs:comment "A clinical history in which there is a of blue or purple spots on the skin or mucus membranes (typical of Kaposi's sarcoma)." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000354 a rdfs:Class ;
  rdfs:label "interpretation of clinical variant protocol"@en ;
  rdfs:comment "A protocol that describe the process of assigning a formal classification to the detected variant"@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:CL_0000711 a rdfs:Class ;
  rdfs:label "cumulus cell" ;
  rdfs:comment """
Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle.
""" ;
  rdfs:subClassOf obo:CL_0000501 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002389 a rdfs:Class ;
  rdfs:label "clinical history of repeated HIV assays" ;
  rdfs:comment "A clinical history in which there is repeated reactive screening assays for human immunodeficiency virus (1 or 2) antibodies regardless of the results of supplemental assays." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000412 a rdfs:Class ;
  rdfs:label "software parameter value"@en ;
  rdfs:comment "Information about software includes information on software parameter value." ;
  rdfs:subClassOf obo:NGBO_6000409 .

<http://www.ebi.ac.uk/efo/EFO_0003036> a rdfs:Class ;
  rdfs:label "clear cell" ;
  rdfs:comment "A cell with empty-appearing cytoplasm when viewed with a light microscope." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000374 a rdfs:Class ;
  rdfs:label "measurement of time between FFPE tissue processor cycle completion and embedding" ;
  rdfs:comment "A time measurement datum that is the result of measuring the time between FFPE tissue processor cycle completion and embedding in a formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0000947 a rdfs:Class ;
  rdfs:label "IgE plasma cell" ;
  rdfs:subClassOf obo:CL_0000974 .

obo:NGBO_6000394 a rdfs:Class ;
  rdfs:label "ligation objective"@en ;
  rdfs:comment "An objective specification to determine attaching synthetic oligonucleotides with known sequences to both or either ends of complementary DNA (cDNA) fragments" ;
  rdfs:subClassOf obo:OBI_0000686 .

obo:OBI_0000828 a rdfs:Class ;
  rdfs:label "research organization" ;
  rdfs:comment "An organization formed with a goal to have its members conduct investigations" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:NGBO_6000259 a rdfs:Class ;
  rdfs:label "compressed file"@en ;
  rdfs:comment "A data item that represent sort of archive that contains one or more files that have been reduced in size through file compression process"@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBIB_0000562 a rdfs:Class ;
  rdfs:label "clinical history of encephalitis" ;
  rdfs:comment "A clinical history in which there was active encephalitis at death." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0002465 a rdfs:Class ;
  rdfs:label "CD11b-positive dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:OBI_0001522 a rdfs:Class ;
  rdfs:label "sequence assembly algorithm"@en ;
  rdfs:comment "An algorithm used to assemble individual sequence reads into larger contiguous sequences (contigs).  Assembly details include but are not limited to assembler type (overlap-layout-consensus, deBruijn), assembler version, and any relevant quality control information such as per cent known genes/ESTs captured."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0002512 a rdfs:Class ;
  rdfs:label "bone marrow specimen" ;
  rdfs:comment "A specimen that is derived from bone marrow." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:PO_0030007 a rdfs:Class ;
  rdfs:label "meristematic apical cell" ;
  rdfs:comment "A single meristematic cell (PO:0004010) at the tip of a plant structure where apical growth occurs." ;
  rdfs:subClassOf obo:PO_0004010 .

obo:PATO_0000918 a rdfs:Class ;
  rdfs:label "volume" ;
  rdfs:comment "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies." ;
  rdfs:subClassOf obo:PATO_0001237 .

obo:OBIB_0000334 a rdfs:Class ;
  rdfs:label "FFPE tissue section H&E staining and mounting SOP" ;
  rdfs:comment "A standard operating procedure for the hematoxylin and eosin (H&E) staining and slide mounting of a formalin-fixed paraffin-embedded (FFPE) tissue section." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:CL_0002025 a rdfs:Class ;
  rdfs:label "CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell" ;
  rdfs:subClassOf obo:CL_0000553 .

obo:OBIB_0000410 a rdfs:Class ;
  rdfs:label "name of data entry person for local pathology review form" ;
  rdfs:comment "A personal name that designates the person who performed the data entry process for filling in a local pathology review form." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:NGBO_6000293 a rdfs:Class ;
  rdfs:label "standard operating procedure title"@en ;
  rdfs:comment "A unique SOP name which captures the essence of the practice described." ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000116> .

obo:NCIT_C81229 a rdfs:Class ;
  rdfs:label "Alcohol Use History" ;
  rdfs:comment "A description of an individual's current and past experience with alcoholic beverage consumption." ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_001196> .

obo:OBIB_0000511 a rdfs:Class ;
  rdfs:label "duration of greater than moderate alcohol consumption prior to enrollment" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration of greater than moderate alcohol consumption (more than 2 drinks per day for a man or more than 1 drink per day for a woman) prior to study enrollment." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0002393 a rdfs:Class ;
  rdfs:label "intermediate monocyte" ;
  rdfs:subClassOf obo:CL_0000576 .

obo:IAO_0000028 a rdfs:Class ;
  rdfs:label "symbol"@en ;
  rdfs:comment "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:CL_0000115 a rdfs:Class ;
  rdfs:label "endothelial cell" ;
  rdfs:comment "The main type of cell found in the inside lining of blood vessels, lymph vessels, and the heart." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000622 a rdfs:Class ;
  rdfs:label "gel permeation column"@en ;
  rdfs:comment "A gel permeation column is a chromatography column which is used in gel permeation chromatography and which employs as the stationary phase a swollen gel made by polymerizing and cross-linking styrene in the presence of a diluent which is a nonsolvent for the styrene polymer. The polymer to be analyzed is introduced at the top of the column and then is elutriated with a solvent. The polymer molecules diffuse through the gel at rates depending on their molecular size."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:BFO_0000011 a rdfs:Class ;
  rdfs:label "spatiotemporal region"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:OMIABIS_0001042 a rdfs:Class ;
  rdfs:label "specimen preparation contact"@en ;
  rdfs:comment "A personal name that designates the person who prepared the specimen."@en ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:CL_0000821 a rdfs:Class ;
  rdfs:label "B-1b B cell" ;
  rdfs:subClassOf obo:CL_0000819 .

obo:CL_0000985 a rdfs:Class ;
  rdfs:label "IgG plasma cell" ;
  rdfs:subClassOf obo:CL_0000974 .

obo:BFO_0000040 a rdfs:Class ;
  rdfs:label "material entity"@en ;
  rdfs:comment "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ;
  rdfs:subClassOf obo:BFO_0000004 .

obo:CL_0002248 a rdfs:Class ;
  rdfs:label "pluripotent stem cell" ;
  rdfs:comment "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." ;
  rdfs:subClassOf obo:CL_0000723 .

obo:NGBO_6000294 a rdfs:Class ;
  rdfs:label "specimen shipping temperature"@en ;
  rdfs:comment "A temperature which represent specimen temperature during shipment." ;
  rdfs:subClassOf obo:PATO_0000146 .

obo:OBI_0001936 a rdfs:Class ;
  rdfs:label "molecular-labeled material" ;
  rdfs:comment "a material entity that is the specified output of an addition of molecular label process that aims to label some molecular target to allow for its detection in a detection of molecular label assay" ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:OBI_0000490 a rdfs:Class ;
  rdfs:label "cation exchange column"@en ;
  rdfs:comment "A cation exchange column is a chromatography column that is used in cation exchange chromatography."@en ;
  rdfs:subClassOf obo:OBI_0000560 .

obo:CL_0000936 a rdfs:Class ;
  rdfs:label "early lymphoid progenitor" ;
  rdfs:subClassOf obo:CL_0000837 .

obo:NCIT_C42775 a rdfs:Class ;
  rdfs:label "E-mail Address" ;
  rdfs:comment "A text string identifier for a location to which e-mail can be delivered." ;
  rdfs:subClassOf obo:IAO_0000577 , obo:NGBO_6000161 .

<http://www.ebi.ac.uk/efo/EFO_0002956> a rdfs:Class ;
  rdfs:label "musculo-skeletal system cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002477 a rdfs:Class ;
  rdfs:label "adipose macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:SO_0000149 a rdfs:Class ;
  rdfs:label "contig" ;
  rdfs:comment "A contiguous sequence derived from sequence assembly. Has no gaps, but may contain N's from unavailable bases." ;
  rdfs:subClassOf obo:SO_0000353 .

obo:OBIB_0000368 a rdfs:Class ;
  rdfs:label "placement of tissue cassette in FFPE fixative delay duration" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration of the the planned delay of placing the tissue cassette in fixative in the formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0000973 a rdfs:Class ;
  rdfs:label "sequence data"@en ;
  rdfs:comment """A measurement datum that representing the primary structure of a macromolecule(it's sequence) sometimes associated with an indicator of confidence of that measurement.
""" ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:IAO_0000577 a rdfs:Class ;
  rdfs:label "centrally registered identifier symbol"@en ;
  rdfs:comment "A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry."@en ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:NGBO_6000160 a rdfs:Class ;
  rdfs:label "training manual"@en ;
  rdfs:comment "A training manual is a book or booklet of instructions, designed to improve the quality of a performed task." ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:CL_0002109 a rdfs:Class ;
  rdfs:label "B220-positive CD38-positive naive B cell" ;
  rdfs:subClassOf obo:CL_0002101 .

obo:CL_0002478 a rdfs:Class ;
  rdfs:label "F4/80-negative adipose macrophage" ;
  rdfs:subClassOf obo:CL_0002477 .

obo:CL_0000101 a rdfs:Class ;
  rdfs:label "sensory neuron" ;
  rdfs:comment "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." ;
  rdfs:subClassOf obo:CL_0000540 .

obo:OBI_0002038 a rdfs:Class ;
  rdfs:label "ribosomal profiling by sequencing assay" ;
  rdfs:comment "A RNA-seq assay that sequences only mRNA protected by the ribosome during translation." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:CL_0000784 a rdfs:Class ;
  rdfs:label "plasmacytoid dendritic cell" ;
  rdfs:comment "A dendritic cell type of distinct morphology, localization, and surface marker expression from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." ;
  rdfs:subClassOf obo:CL_0000451 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000081 a rdfs:Class ;
  rdfs:label "information about local data storage"@en ;
  rdfs:comment "Information about data storage location information content entity which represent any physical hardware such as external hard drives, flash drives, and CD" ;
  rdfs:subClassOf obo:NGBO_6000399 .

obo:OBI_0000796 a rdfs:Class ;
  rdfs:label "purification objective" ;
  rdfs:comment "The objective to separate a material entity into different compositions of which one or more have are purified fractions that contain higher concentration of a desired component, while others contain impurities and are not of interest" ;
  rdfs:subClassOf obo:OBI_0000681 .

obo:OBIB_0000296 a rdfs:Class ;
  rdfs:label "adherence of dehydration process temperature to FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether temperature of the dehydration process followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:OBI_0000747 a rdfs:Class ;
  rdfs:label "material sample" ;
  rdfs:comment "A material entity that has the material sample role" ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0001115 a rdfs:Class ;
  rdfs:label "ELISA microplate washer" ;
  rdfs:comment "A microplate washer that is used for enzyme-linked immunosorbent assays (ELISA)." ;
  rdfs:subClassOf obo:OBI_0001113 .

obo:OBI_0001852 a rdfs:Class ;
  rdfs:label "paired-end library preparation"@en ;
  rdfs:comment "A library preparation that results in the creation of a library of the 5' and 3' ends of DNA or cDNA fragments using adaptors and endonucleases. The preparation may or may not include cloning process. " ;
  rdfs:subClassOf obo:OBI_0000711 .

obo:OBI_0400105 a rdfs:Class ;
  rdfs:label "arrayer"@en ;
  rdfs:comment "a device which deposits biological material onto a substrate in a defined pattern."@en ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:OBI_0000070 a rdfs:Class ;
  rdfs:label "assay"@en ;
  rdfs:comment "A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies."@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0002566 a rdfs:Class ;
  rdfs:label "file merge" ;
  rdfs:comment "A data transformation in which data contained in 2 or more files are merged into a single file." ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0000932 a rdfs:Class ;
  rdfs:label "material separation device" ;
  rdfs:comment "A device with a separation function realized in a planed process" ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:CL_0001010 a rdfs:Class ;
  rdfs:label "mature dermal dendritic cell" ;
  rdfs:subClassOf obo:CL_0001006 .

obo:OBI_0001897 a rdfs:Class ;
  rdfs:label "organization of sequencing facility contact person"@en ;
  rdfs:comment "An organization that is the affiliation of the contact representative at the sequencing facility" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:NGBO_6000307 a rdfs:Class ;
  rdfs:label "benign variant"@en ;
  rdfs:comment "A clinical variant interpretation that represents a sequence variant previously classified or reported as a recognized neutral variant" ;
  rdfs:subClassOf obo:NGBO_6000302 .

obo:OBIB_0000341 a rdfs:Class ;
  rdfs:label "manual FFPE tissue section H&E deparaffinization" ;
  rdfs:comment "A planned process involving the manual performance of the FFPE tissue section H&E deparaffinization protocol." ;
  rdfs:subClassOf obo:OMIABIS_0000911 .

obo:CL_0000998 a rdfs:Class ;
  rdfs:label "CD8_alpha-negative CD11b-negative dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:CL_0002371 a rdfs:Class ;
  rdfs:label "somatic cell" ;
  rdfs:comment "One of the cells of the body that compose the tissues, organs, and parts of that individual other than the germ cells." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002008 a rdfs:Class ;
  rdfs:label "CD34-positive, CD38-positive eosinophil progenitor cell" ;
  rdfs:subClassOf obo:CL_0000611 .

obo:OBI_0002519 a rdfs:Class ;
  rdfs:label "skeletal muscle tissue specimen" ;
  rdfs:comment "A specimen that is derived from skeletal muscle." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000859 a rdfs:Class ;
  rdfs:label "cytoplasmic RNA extraction" ;
  rdfs:comment "A RNA extraction process in which the desired output material is RNA in the cytoplasm." ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:CL_0000614 a rdfs:Class ;
  rdfs:label "basophilic myelocyte" ;
  rdfs:subClassOf obo:CL_0000768 .

obo:OBIB_0000527 a rdfs:Class ;
  rdfs:label "time since last usage of hormonal birth control" ;
  rdfs:comment "A time measurement datum that is the result of measuring the time elapsed since the participant last used hormonally based birth control." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBIB_0000414 a rdfs:Class ;
  rdfs:label "specimen transport from OR to gross room SOP" ;
  rdfs:comment "A specimen transport SOP governing the transport of tissue from the operating room (OR) to the pathology gross room." ;
  rdfs:subClassOf obo:OBIB_0000071 .

obo:OBI_0000621 a rdfs:Class ;
  rdfs:label "custom made column"@en ;
  rdfs:comment "A custom made column ia a chromatography column which is specifically tailored according to the needs of the separation as requested by a scientist or working group."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CL_0000173 a rdfs:Class ;
  rdfs:label "pancreatic D cell" ;
  rdfs:comment "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0002966> .

obo:CL_0000886 a rdfs:Class ;
  rdfs:label "nasal and broncial associated lymphoid tissue macrophage" ;
  rdfs:subClassOf obo:CL_0000884 .

obo:OBI_0002024 a rdfs:Class ;
  rdfs:label "SOLiD 4 System" ;
  rdfs:comment "An AB SOLid System which is manufacted by the Applied Biosystems corporation. Built upon SOLiD sequencing technology, the machine generates greater than 1 billion mappable reads per run." ;
  rdfs:subClassOf obo:OBI_0000696 .

obo:OBIB_0000313 a rdfs:Class ;
  rdfs:label "total time FFPE freshly poured blocks were cooled" ;
  rdfs:comment "A time measurement datum that is the result of measuring the total time that freshly poured blocks were cooled in the formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0000583 a rdfs:Class ;
  rdfs:label "alveolar macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:OBI_1110109 a rdfs:Class ;
  rdfs:label "target of material addition" ;
  rdfs:comment "A material entity into which another is being added in a material combinatino process" ;
  rdfs:subClassOf obo:BFO_0000040 .

<http://www.ebi.ac.uk/efo/EFO_0005023> a rdfs:Class ;
  rdfs:label "adipose tissue derived mesenchymal stem cell"@en ;
  rdfs:comment "A adult mesenchymal stem cell derived from adipose tisssue" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000586> .

obo:CL_0001008 a rdfs:Class ;
  rdfs:label "Kit and Sca1-positive hematopoietic stem cell" ;
  rdfs:subClassOf obo:CL_0000037 .

<http://www.ebi.ac.uk/efo/EFO_0004950> a rdfs:Class ;
  rdfs:label "date of birth"@en ;
  rdfs:comment "The point in time at which an individual was born." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0000048 a rdfs:Class ;
  rdfs:label "multipotent stem cell" ;
  rdfs:comment "A stem cell that can give rise to mulitple lineages of cells." ;
  rdfs:subClassOf obo:CL_0000034 .

obo:OMIABIS_0001054 a rdfs:Class ;
  rdfs:label "normal specimen"@en ;
  rdfs:comment "A specimen that is normal."@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:NGBO_6000098 a rdfs:Class ;
  rdfs:label "specimen collection kit"@en ;
  rdfs:comment "An assay kit processed material comprises a sterile device for collecting a sample, a collection and dispersing device for depositing and holding the sample, a device for transferring the sample, and a container for storing the sample to be tested. There may also be a labeling system for identifying the sample and for diluting the sample" ;
  rdfs:subClassOf obo:NGBO_6000236 .

obo:CL_0000499 a rdfs:Class ;
  rdfs:label "stromal cell" ;
  rdfs:comment "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000306 a rdfs:Class ;
  rdfs:label "adherence of paraffin temperature to FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether the paraffin temperature followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:OBI_0001615 a rdfs:Class ;
  rdfs:label "investigation description"@en ;
  rdfs:comment "A textual entity that describes an investigation."@en ;
  rdfs:subClassOf obo:IAO_0000300 .

obo:OBI_0200031 a rdfs:Class ;
  rdfs:label "differential expression analysis objective"@en ;
  rdfs:comment "A differential expression analysis objective is a data transformation objective whose input consists of expression levels of entities (such as transcripts or proteins), or of sets of such expression levels, under two or more conditions and whose output reflects which of these are likely to have different expression across such conditions."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0001019 a rdfs:Class ;
  rdfs:label "CD115-positive monocyte OR common dendritic progenitor" ;
  rdfs:subClassOf obo:CL_0002031 .

obo:CL_0000864 a rdfs:Class ;
  rdfs:label "tissue-resident macrophage" ;
  rdfs:subClassOf obo:CL_0000235 .

obo:OBIB_0000551 a rdfs:Class ;
  rdfs:label "clinical history of cellulitis" ;
  rdfs:comment "A clinical history in which there is a history of cellulitis." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:BFO_0000027 a rdfs:Class ;
  rdfs:label "object aggregate"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:CL_0000127 a rdfs:Class ;
  rdfs:label "astrocyte" ;
  rdfs:comment "cells) are irregularly shaped with many long processes, including those with \"end feet\" which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and" ;
  rdfs:subClassOf obo:CL_0000125 .

obo:OBIB_0000591 a rdfs:Class ;
  rdfs:label "clinical history of Hepatitis B" ;
  rdfs:comment "A clinical history in which there is a history of Hepatitis B infection." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBIB_0000335 a rdfs:Class ;
  rdfs:label "FFPE tissue section H&E staining in oven duration" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration in an oven for the hematoxylin and eosin staining of a formalin-fixed paraffin-embedded (FFPE) tissue section." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0002394 a rdfs:Class ;
  rdfs:label "CD141-positive myeloid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000782 .

obo:IAO_0000100 a rdfs:Class ;
  rdfs:label "data set"@en ;
  rdfs:comment "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000345 a rdfs:Class ;
  rdfs:label "mass analyzer"@en ;
  rdfs:comment "A Mass analyzer is a device that separates ions according to their mass-to-charge ratio. All mass spectrometers are based on dynamics of charged particles in electric and magnetic fields in vacuum where the two laws of Lorentz force law and Newton's second law of motion apply."@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0000932 .

obo:CL_0002397 a rdfs:Class ;
  rdfs:label "CD14-positive, CD16-positive monocyte" ;
  rdfs:subClassOf obo:CL_0002393 .

obo:OBI_0000893 a rdfs:Class ;
  rdfs:label "real time polymerase chain reaction assay" ;
  rdfs:comment "An assay, based on the PCR, that amplifies and simultaneously quantifies a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample." ;
  rdfs:subClassOf obo:NGBO_6000264 , obo:OBI_0000070 .

obo:CL_0002036 a rdfs:Class ;
  rdfs:label "Slamf1-positive multipotent progenitor cell" ;
  rdfs:subClassOf obo:CL_0000837 .

obo:OBI_0000962 a rdfs:Class ;
  rdfs:label "training objective" ;
  rdfs:comment "An objective specification which is fulfilled by the provision of some training." ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0002504 a rdfs:Class ;
  rdfs:label "digestive system fluid or secretion specimen" ;
  rdfs:comment "A specimen that is derived from digestive system fluid or secretion." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:NGBO_6000410 a rdfs:Class ;
  rdfs:label "bioinformatics software name"@en ;
  rdfs:comment "Information about software includes software name" ;
  rdfs:subClassOf obo:NGBO_6000409 .

obo:CL_0002319 a rdfs:Class ;
  rdfs:label "neural cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000502 a rdfs:Class ;
  rdfs:label "time since hormonal therapy was received prior to surgery" ;
  rdfs:comment "A time measurement datum that is the result of measuring the time elapsed since hormonal therapy prior to surgery." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:NGBO_6000261 a rdfs:Class ;
  rdfs:label "genetic variantion analysis"@en ;
  rdfs:comment "A bioinformatics analysis which analyse a genetic variation, for example to annotate its location, alleles, classification, and effects on individual transcripts predicted for a gene model." ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:CL_0000979 a rdfs:Class ;
  rdfs:label "IgG memory B cell" ;
  rdfs:subClassOf obo:CL_0000972 .

obo:CL_0000037 a rdfs:Class ;
  rdfs:label "hematopoietic stem cell" ;
  rdfs:comment "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002015 a rdfs:Class ;
  rdfs:label "Kit-negative, Ly-76 high polychromatophilic erythroblast" ;
  rdfs:subClassOf obo:CL_0000550 .

obo:IAO_0000572 a rdfs:Class ;
  rdfs:label "documenting"@en ;
  rdfs:comment "a planned process in which a document is created or added to by including the specified input in it."@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:BTO_0001615 a rdfs:Class ;
  rdfs:label "colorectal cancer cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0005934> .

obo:OBI_0200173 a rdfs:Class ;
  rdfs:label "background correction objective"@en ;
  rdfs:comment "A background correction objective is a data transformation objective where the aim is to remove irrelevant contributions from the measured signal, e.g. those due to instrument noise or sample preparation."@en ;
  rdfs:subClassOf obo:OBI_0200168 .

obo:GENEPIO_0001562 a rdfs:Class ;
  rdfs:label "reference genome identifier"@en ;
  rdfs:comment "Identifier for a reference genome (used to build or compare an assembly)  that is used in the genome browsers and in the community"@en ;
  rdfs:subClassOf obo:GENEPIO_0001800 , obo:NGBO_6000244 .

obo:OBI_0001879 a rdfs:Class ;
  rdfs:label "reagent"@en ;
  rdfs:comment "A biological or chemical entity that bears a reagent role in virtue of it being intended for application in a scientific technique  to participate in (or have molecular parts that participate in) a chemical reaction that facilitates the generation of data about some distinct entity, or the generation of some distinct material specified output." ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:BFO_0000023 a rdfs:Class ;
  rdfs:label "role"@en ;
  rdfs:comment "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts."@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:OBI_0000603 a rdfs:Class ;
  rdfs:label "liquid chromatography column"@en ;
  rdfs:comment "A liquid chromatography column is a chromatography column that is used in liquid chromatography, i.e. a column that is provided with a liquid sample mix."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:NGBO_6000182 a rdfs:Class ;
  rdfs:label "genome indexing"@en ;
  rdfs:comment "A bioinformatics analysis which referes to the process of compressing to reduze the size of genome file" ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:OBI_0000639 a rdfs:Class ;
  rdfs:label "material separation objective" ;
  rdfs:comment "is an objective to transform a material entity into spatially separated components." ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:OBI_0000710 a rdfs:Class ;
  rdfs:label "Li-Cor 4300 DNA Analysis System" ;
  rdfs:comment "is a DNA sequencer which is manufactured by Li-Cor corporation and enable automated chain termination based DNA sequencing" ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:NGBO_6000004 a rdfs:Class ;
  rdfs:label "VCF format"@en ;
  rdfs:comment "A file format which represent represent the format of a text file used in bioinformatics for storing gene sequence variations" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:OBIB_0000500 a rdfs:Class ;
  rdfs:label "time since chemotherapy was received prior to surgery" ;
  rdfs:comment "A time measurement datum that is the result of measuring the time elapsed since chemotherapy prior to surgery." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0002123 a rdfs:Class ;
  rdfs:label "B220-low CD38-positive IgG-negative class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0002119 .

obo:OBI_0600014 a rdfs:Class ;
  rdfs:label "material component separation"@en ;
  rdfs:comment "a material processing in which components of an input material become segregated in space"@en ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:PO_0030014 a rdfs:Class ;
  rdfs:label "gametophyte meristematic apical cell" ;
  rdfs:comment "An apical cell that is part of a whole plant in the gametophytic phase." ;
  rdfs:subClassOf obo:PO_0030007 .

obo:OBI_0001673 a rdfs:Class ;
  rdfs:label "nano-cap analysis of gene expression assay" ;
  rdfs:comment "A transcription profiling assay that is performed using a very low amount (nanogram scale) of mRNA samples using Cap analysis gene expression (CAGE)." ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:CL_0002058 a rdfs:Class ;
  rdfs:label "Gr1-low non-classical monocyte" ;
  rdfs:subClassOf obo:CL_0000875 .

obo:OBI_0002689 a rdfs:Class ;
  rdfs:label "detection of pathogenic organisms objective" ;
  rdfs:comment "An organism feature identification objective that aims to detect whether an organism contains pathogenic organisms." ;
  rdfs:subClassOf obo:OBI_0000268 .

obo:CL_0002104 a rdfs:Class ;
  rdfs:label "IgG-negative double negative memory B cell" ;
  rdfs:subClassOf obo:CL_0000981 .

obo:CL_0002192 a rdfs:Class ;
  rdfs:label "metamyelocyte" ;
  rdfs:subClassOf obo:CL_0002191 .

obo:NGBO_6000195 a rdfs:Class ;
  rdfs:label "whole exome sequence data"@en ;
  rdfs:comment "A mesurement datum that represent all of the protein-coding regions of genes in a genome (known as the exome)"@en ;
  rdfs:subClassOf obo:OBI_0001573 .

obo:OBI_0002143 a rdfs:Class ;
  rdfs:label "bromouride labeling and sequencing after UV exposure" ;
  rdfs:comment "An RNA-seq assay to identify transcription start sites and active enhancer elements through isolation of bromouridine (Bru) labelled RNAs after UV light exposure introduces transcription-blocking lesions." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:PATO_0001237 a rdfs:Class ;
  rdfs:label "quality of a single physical entity"@en ;
  rdfs:comment "A physical object quality which inheres in a single-bearer."@en ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:OBI_0002572 a rdfs:Class ;
  rdfs:label "polyA-depleted RNA sequencing assay" ;
  rdfs:comment "An RNA-seq assay to study non-polyadenylated transcripts, such as, but not exclusive to unspliced and circular isoforms, through the depletion of polyadenylated transcripts prior to high-throughput sequencing." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:NGBO_6000181 a rdfs:Class ;
  rdfs:label "database index"@en ;
  rdfs:comment "A bioinformatics analysis that produces data structure that improves the speed of data retrieval operations on a database table at the cost of additional writes and storage space to maintain the index data structure" ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:CL_0000788 a rdfs:Class ;
  rdfs:label "naive B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:CL_0002111 a rdfs:Class ;
  rdfs:label "CD38-negative unswitched memory B cell" ;
  rdfs:subClassOf obo:CL_0000970 .

obo:OBI_0001271 a rdfs:Class ;
  rdfs:label "RNA-seq assay" ;
  rdfs:comment "An transcription profiling assay that determines an RNA sequence by analyzing the transcibed regions of the genome and or to quantitate transcript abundance." ;
  rdfs:subClassOf obo:OBI_0000424 , obo:OBI_0600047 .

obo:CL_0002473 a rdfs:Class ;
  rdfs:label "MHC-II-high non-classical monocyte" ;
  rdfs:subClassOf obo:CL_0002058 .

obo:OBI_0302888 a rdfs:Class ;
  rdfs:label "washing"@en ;
  rdfs:comment "washing is a process by which a material entity acting as  contaminant (e.g. excess staining reagent) is removed by application of one or more cycles of solution in flow."@en ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:NGBO_0000038 a rdfs:Class ;
  rdfs:label "DNA processed specimen"@en ;
  rdfs:comment "A  processed specimen which is the output of preparing a DNA sample for further analysis." ;
  rdfs:subClassOf obo:OBI_0000953 .

obo:CL_0002004 a rdfs:Class ;
  rdfs:label "CD34-negative, GlyA-negative proerythroblast" ;
  rdfs:subClassOf obo:CL_0000547 .

obo:OMRSE_00000038 a rdfs:Class ;
  rdfs:label "legal person role"@en ;
  rdfs:comment "A role borne by a human individual or by a collection of humans regarded as possessing rights and duties enforeable at law."@en ;
  rdfs:subClassOf obo:OMRSE_00000024 .

obo:OBI_0000131 a rdfs:Class ;
  rdfs:label "molecular feature identification objective"@en ;
  rdfs:comment "Molecular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize molecular features of a biological system, e.g. expression profiling, copy number of molecular components, epigenetic modifications."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:CL_2000058 a rdfs:Class ;
  rdfs:label "calvarial osteoblast" ;
  rdfs:comment "Any osteoblast that is part of a skull. [ GOC:TermGenie ] " ;
  rdfs:subClassOf obo:CL_0000062 .

obo:CL_0000557 a rdfs:Class ;
  rdfs:label "granulocyte monocyte progenitor cell" ;
  rdfs:comment "A progenitor cell that has plasma membrane part CD123, CD34, and CD45RA, lacks plasma membrane part CD19 and CD3, and is committed to the granulocyte and monocyte lineages." ;
  rdfs:subClassOf obo:CL_0002032 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000969 a rdfs:Class ;
  rdfs:label "regulatory B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:OBI_0000651 a rdfs:Class ;
  rdfs:label "urine specimen" ;
  rdfs:comment "a portion of urine collected from an organism" ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0002044 a rdfs:Class ;
  rdfs:label "Kit-positive, integrin beta7-high basophil mast progenitor cell" ;
  rdfs:subClassOf obo:CL_0002028 .

obo:IAO_0000644 a rdfs:Class ;
  rdfs:label "statistical analysis section"@en ;
  rdfs:comment "A part of the document used to describe the statistical methodologies employed in the work presented in the document."@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:OBI_0001618 a rdfs:Class ;
  rdfs:label "average depth of sequence coverage"@en ;
  rdfs:comment "An average value of the depth of sequence coverage based both on external (e.g. Cot-based size estimates) and internal (average coverage in the assembly) measures of genome size."@en ;
  rdfs:subClassOf obo:OBI_0000679 .

obo:NGBO_6000232 a rdfs:Class ;
  rdfs:label "data validation"@en ;
  rdfs:comment "A planned process which ensure data have undergone data cleansing to ensure they have data quality, that is, that they are both correct and useful." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBIB_0000580 a rdfs:Class ;
  rdfs:label "clinical history of a prolonged fever" ;
  rdfs:comment "A clinical history in which there is a history of  fever of at least 38.6 Celsius for a specified duration." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0001051 a rdfs:Class ;
  rdfs:label "DNA extract" ;
  rdfs:comment "The output of an extraction process in which DNA molecules are purified in order to exclude DNA from organellas." ;
  rdfs:subClassOf obo:NGBO_6000106 , obo:OBI_0001010 .

obo:OBI_0000401 a rdfs:Class ;
  rdfs:label "environment control function"@en ;
  rdfs:comment "An environmental control function is a function that regulates a contained environment within specified parameter ranges. For example the control of light exposure, humidity and temperature."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0200005 a rdfs:Class ;
  rdfs:label "feature extraction objective"@en ;
  rdfs:comment "A feature extraction objective is a data transformation objective where the aim of the data transformation is to generate quantified values from a scanned image."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0000828 a rdfs:Class ;
  rdfs:label "thromboblast" ;
  rdfs:subClassOf obo:CL_0000839 .

obo:CL_0000777 a rdfs:Class ;
  rdfs:label "mesangial phagocyte" ;
  rdfs:comment "A tissue-resident macrophage of the renal glomerular mesangium." ;
  rdfs:subClassOf obo:CL_0000864 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:BFO_0000016 a rdfs:Class ;
  rdfs:label "disposition"@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:OBI_0100067 a rdfs:Class ;
  rdfs:label "bronchial alveolar lavage"@en ;
  rdfs:comment "Group of biomaterials present in the bronchial aveolar space of an organism which are collected through lavage including the reagents used to for the lavage process, organisms, cells, and cellular secretions present in the bronchial aveolar space."@en ;
  rdfs:subClassOf obo:OBI_0000953 .

<http://www.ebi.ac.uk/efo/EFO_0002662> a rdfs:Class ;
  rdfs:label "dendritic cell-derived osteoclast" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000704 a rdfs:Class ;
  rdfs:label "decision tree induction objective" ;
  rdfs:comment "A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made." ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002515 a rdfs:Class ;
  rdfs:label "pleural fluid specimen" ;
  rdfs:comment "A specimen that is derived from pleural fluid." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000889 a rdfs:Class ;
  rdfs:label "myeloid suppressor cell" ;
  rdfs:subClassOf obo:CL_0000766 .

obo:OBI_0002534 a rdfs:Class ;
  rdfs:label "lung specimen" ;
  rdfs:comment "A specimen that is derived from lung." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0002633 a rdfs:Class ;
  rdfs:label "repiratory basal cell" ;
  rdfs:comment "A basal cell in the respiratory tract. [ PMID:20699479 GOC:tfm ] " ;
  rdfs:subClassOf obo:CL_0000646 .

obo:BFO_0000050 a rdf:Property ;
  rdfs:label "part of"@en ;
  rdfs:comment "a core relation that holds between a part and its whole"@en ;
  rdfs:seeAlso <http://www.obofoundry.org/ro/#OBO_REL:part_of> ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:CL_0000415 a rdfs:Class ;
  rdfs:label "diploid cell" ;
  rdfs:comment "A cell whose nucleus has two haploid genomes." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000266 a rdfs:Class ;
  rdfs:label "name of person processing blood cell pellet specimen" ;
  rdfs:comment "A personal name that designates the person who performed processing of the blood cell pellet specimen." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBIB_0000559 a rdfs:Class ;
  rdfs:label "clinical history of cancer within a time period before death" ;
  rdfs:comment "A clinical history in which there is a history of cancer diagnosis within a specified time frame." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0002459 a rdfs:Class ;
  rdfs:label "langerin-negative dermal  dendritic cell" ;
  rdfs:subClassOf obo:CL_0001006 .

<http://www.ebi.ac.uk/efo/EFO_0002966> a rdfs:Class ;
  rdfs:label "pancreatic cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002231 a rdfs:Class ;
  rdfs:label "epithelial cell of prostate" ;
  rdfs:comment "An epithelial cell of the prostate." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:CL_0000552 a rdfs:Class ;
  rdfs:label "orthochromatic erythroblast" ;
  rdfs:subClassOf obo:CL_0000765 .

obo:IAO_0000030 a rdfs:Class ;
  rdfs:label "information content entity"@en ;
  rdfs:comment "A generically dependent continuant that is about some thing."@en ;
  rdfs:subClassOf obo:BFO_0000031 .

obo:NGBO_6000225 a rdfs:Class ;
  rdfs:label "sequence similarity search"@en ;
  rdfs:comment "A bioinformatics analysis which attempt to searching sequence databases by using alignment to a query sequence" ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:CL_0000817 a rdfs:Class ;
  rdfs:label "precursor B cell" ;
  rdfs:comment "A precursor B cell is a B cell with the phenotype CD10-positive (P08473/NEP_HUMAN; PIRSF001194)." ;
  rdfs:subClassOf obo:CL_0000236 .

obo:OBI_0002131 a rdfs:Class ;
  rdfs:label "Illumina Infinium MethylationEPIC BeadChip"@en ;
  rdfs:comment "An Illumina methylation BeadChip which is an array that interrogates ~ 850,000 methylation sites per sample at single-nucleotide resolution."@en ;
  rdfs:subClassOf obo:OBI_0001870 .

obo:OBI_0000370 a rdfs:Class ;
  rdfs:label "contain function"@en ;
  rdfs:comment "A contain function is a function to constrain a material entities location in space"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:CL_0000841 a rdfs:Class ;
  rdfs:label "mature conventional dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:PATO_0001995 a rdfs:Class ;
  rdfs:label "organismal quality" ;
  rdfs:comment "A quality that inheres in an entire organism or part of an organism." ;
  rdfs:subClassOf obo:PATO_0001241 .

obo:CL_0000112 a rdfs:Class ;
  rdfs:label "columnar neuron" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000740 a rdfs:Class ;
  rdfs:label "material sample role" ;
  rdfs:comment "A material sample role is a specimen role borne by a material entity that is the output of a material sampling process." ;
  rdfs:subClassOf obo:OBI_0000112 .

obo:NGBO_6000193 a rdfs:Class ;
  rdfs:label "gene expression profile data"@en ;
  rdfs:comment "A measured expression level which refers to activity (the expression) of thousands of genes at once, to create a global picture of cellular function." ;
  rdfs:subClassOf obo:OBI_0000101 .

obo:PATO_0000122 a rdfs:Class ;
  rdfs:label "length" ;
  rdfs:comment "A 1-D extent quality which is equal to the distance between two points." ;
  rdfs:subClassOf obo:BFO_0000019 .

<http://www.ebi.ac.uk/efo/EFO_0003076> a rdfs:Class ;
  rdfs:label "thyrocyte" ;
  rdfs:comment "An epithelial cell lining the thyroid follicle." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:IAO_0000633 a rdfs:Class ;
  rdfs:label "materials section"@en ;
  rdfs:comment "A part of a document about the materials required to reproduce the content of the document."@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:NGBO_6000362 a rdfs:Class ;
  rdfs:label "validation of known variant protocol"@en ;
  rdfs:comment "A protocol which describe the process of validation of known variant" ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:NGBO_0000061 a rdfs:Class ;
  rdfs:label "PM3 criteria"@en ;
  rdfs:comment "For recessive disorders, detected in trans with a pathogenic variant" ;
  rdfs:subClassOf obo:NGBO_0000065 .

obo:OBI_0001335 a rdfs:Class ;
  rdfs:label "microRNA profiling by array assay" ;
  rdfs:comment "An assay that analyses the microRNA component of the transcriptome using a microRNA array." ;
  rdfs:subClassOf obo:OBI_0001926 .

obo:CL_0000875 a rdfs:Class ;
  rdfs:label "non-classical monocyte" ;
  rdfs:subClassOf obo:CL_0000576 .

obo:OBIB_0000255 a rdfs:Class ;
  rdfs:label "cryovial specimen barcode" ;
  rdfs:comment "A specimen barcode that is associated with a cryovial." ;
  rdfs:subClassOf obo:FLU_0001019 .

obo:CL_0000550 a rdfs:Class ;
  rdfs:label "polychromatophilic erythroblast" ;
  rdfs:subClassOf obo:CL_0000765 .

obo:OBI_0000941 a rdfs:Class ;
  rdfs:label "service consumer role" ;
  rdfs:comment "a role which inheres in a person who uses a service" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:CL_0000337 a rdfs:Class ;
  rdfs:label "neuroblast (sensu Vertebrata)" ;
  rdfs:comment "An embryonic cell that develops into a nerve cell or neuron." ;
  rdfs:subClassOf obo:CL_0000047 .

obo:OMIABIS_0001043 a rdfs:Class ;
  rdfs:label "time in formalin measurement"@en ;
  rdfs:comment "A time measurement datum that states the duration during which a specimen was submerged in formalin."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:NCBITaxon_7742 a rdfs:Class ;
  rdfs:label "Vertebrata <Metazoa>" ;
  rdfs:subClassOf obo:NCBITaxon_33213 .

obo:OBIB_0000070 a rdfs:Class ;
  rdfs:label "standard operating procedure" ;
  rdfs:comment "A protocol that is a set of step-by-step instructions compiled by an organization for carrying out routine operations." ;
  rdfs:subClassOf obo:IAO_0000310 , obo:OBI_0000272 .

obo:OBIB_0000302 a rdfs:Class ;
  rdfs:label "adherence of temperature of clearing agent to FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether the temperature of clearing agent followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:CL_0000083 a rdfs:Class ;
  rdfs:label "exocrine pancreas cell" ;
  rdfs:comment "An epithelial cell of the pancreas." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002508 a rdfs:Class ;
  rdfs:label "sputum specimen" ;
  rdfs:comment "A specimen that is derived from sputum." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:NCIT_C25621 a rdfs:Class ;
  rdfs:label "Postal Code" ;
  rdfs:comment "Any system designed to expedite the sorting and delivery of mail by assigning a series of alphanumeric codes to each delivery area. Also used to refer to any individual delivery area code." ;
  rdfs:subClassOf obo:IAO_0000577 , obo:NGBO_6000161 .

obo:CL_0000050 a rdfs:Class ;
  rdfs:label "megakaryocyte-erythroid progenitor cell" ;
  rdfs:subClassOf obo:CL_0002032 .

obo:CL_0000763 a rdfs:Class ;
  rdfs:label "myeloid cell" ;
  rdfs:comment "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000272 a rdfs:Class ;
  rdfs:label "protocol"@en ;
  rdfs:comment "A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0002041 a rdfs:Class ;
  rdfs:label "self-transcribing active regulatory region sequencing assay" ;
  rdfs:comment "An RNA-seq assay that identifies the sequences that act as transcriptional enhancers in a direct, quantitative, and genome-wide manner from sheared genomic DNA." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:CL_0000870 a rdfs:Class ;
  rdfs:label "Peyer's patch macrophage" ;
  rdfs:subClassOf obo:CL_0000885 .

obo:CL_0002019 a rdfs:Class ;
  rdfs:label "Ly-76 high reticulocyte" ;
  rdfs:subClassOf obo:CL_0002422 .

obo:OMIABIS_0000046 a rdfs:Class ;
  rdfs:label "CTEP organization identifier"@en ;
  rdfs:comment "An identifier for an organization that is assigned to that organization by the Cancer Therapy Evaluation Program."@en ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:NGBO_6000009 a rdfs:Class ;
  rdfs:label "unstained fixed tissue slide"@en ;
  rdfs:comment "A fixed tissue slide specimen that is contain unstained tissue section(s)" ;
  rdfs:subClassOf obo:OMIABIS_0000052 .

obo:OMIABIS_0000050 a rdfs:Class ;
  rdfs:label "fixed tissue specimen"@en ;
  rdfs:comment "A processed specimen that is the output of a fixation process."@en ;
  rdfs:subClassOf obo:OBI_0000953 .

obo:OBI_0000458 a rdfs:Class ;
  rdfs:label "manufacturing objective"@en ;
  rdfs:comment "is the objective to manufacture a material of a certain function (device)"@en ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:OMIABIS_0001080 a rdfs:Class ;
  rdfs:label "sample handling"@en ;
  rdfs:comment "A planned process of preparing and submitting specimens to storage."@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0002583 a rdfs:Class ;
  rdfs:label "DNA methylation profiling data" ;
  rdfs:comment "The results of a DNA methylation profiling assay" ;
  rdfs:subClassOf obo:OBI_0000973 .

<http://semanticscience.org/resource/SIO_010053> a rdfs:Class ;
  rdfs:label "evolutionary lineage"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_001196> .

obo:OBI_0002545 a rdfs:Class ;
  rdfs:label "ileum specimen" ;
  rdfs:comment "A specimen that is derived from ileum." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBIB_0000035 a rdfs:Class ;
  rdfs:label "blood spotting"@en ;
  rdfs:comment "An adding specimen into a container process that spots the blood from an organism on the blood spot card." ;
  rdfs:subClassOf obo:OBIB_0000034 .

obo:CL_0000647 a rdfs:Class ;
  rdfs:label "multinucleated giant cell" ;
  rdfs:subClassOf obo:CL_0000766 .

<http://www.ebi.ac.uk/efo/EFO_0009498> a rdfs:Class ;
  rdfs:label "MSiPS" ;
  rdfs:comment "Induced pluripotent stem cell line from a Caucasian male with type 2 diabetes, same donor as of MSLCL cell line." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0004905> .

obo:RO_0000086 a rdf:Property ;
  rdfs:label "has quality" ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range obo:BFO_0000019 ;
  rdfs:subPropertyOf obo:RO_0000053 .

obo:CL_0000774 a rdfs:Class ;
  rdfs:label "band form eosinophil" ;
  rdfs:subClassOf obo:CL_0000772 .

obo:CL_0002322 a rdfs:Class ;
  rdfs:label "embryonic stem cell" ;
  rdfs:comment "Totipotent cell cultured from early embryo. Have the advantage that following modification in vitrothey can be used to produce chimeric embryos and thus transgenic animals." ;
  rdfs:subClassOf obo:CL_0000034 .

<http://www.ebi.ac.uk/efo/EFO_0004038> a rdfs:Class ;
  rdfs:label "mouse embryonic stem cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:BFO_0000001 a rdfs:Class ;
  rdfs:label "entity"@en .

obo:NGBO_6000323 a rdfs:Class ;
  rdfs:label "target region enrichment assay"@en ;
  rdfs:comment "A material processing which capture specific regions of interest after library preparation for next generation sequencing." ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:CL_0002115 a rdfs:Class ;
  rdfs:label "B220-positive CD38-positive unswitched memory B cell" ;
  rdfs:subClassOf obo:CL_0002114 .

obo:CL_0002618 a rdfs:Class ;
  rdfs:label "endothelial cell of umbilical vein" ;
  rdfs:comment "An endothelial cell of the umbilical vein. [ GOC:tfm ] " ;
  rdfs:subClassOf obo:CL_0000071 .

obo:OBI_0000407 a rdfs:Class ;
  rdfs:label "viral RNA extraction"@en ;
  rdfs:comment "The extraction of RNA from an input material that specifically isolates viral RNA" ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:CL_0002030 a rdfs:Class ;
  rdfs:label "Fc-epsilon RIalpha-high basophil progenitor cell" ;
  rdfs:subClassOf obo:CL_0000613 .

obo:OBI_0002511 a rdfs:Class ;
  rdfs:label "vitreous humor specimen" ;
  rdfs:comment "A specimen that is derived from vireous humor." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002190 a rdfs:Class ;
  rdfs:label "courier organization"@en ;
  rdfs:comment "An organization that delivers messages, packages, and mail." ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0000628 a rdfs:Class ;
  rdfs:label "carbon nanotube column"@en ;
  rdfs:comment "Carbon nanotubes (CNTs) are known to have high thermal and mechanical stability and have the potential to be high-performance separation media that utilize the nanoscale interactions. CNT can be applied in long capillary tubes for the development of gas chromatography columns. A film of CNTs can be deposited by chemical vapor deposition (CVD) to form the stationary phase in the open tubular format. Altering the CVD conditions can vary the thickness and the morphology of the CNT film, which opens the possibility of selectivity tuning. The ability to fabricate long tubes coated with CNTs can be readily employed in other gas- and liquid-phase separations as well."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0000967 a rdfs:Class ;
  rdfs:label "container" ;
  rdfs:comment "A device that can be used to restrict the location of material entities over time" ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:CL_0002532 a rdfs:Class ;
  rdfs:label "CD16-positive myeloid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000782 .

obo:OBI_0002551 a rdfs:Class ;
  rdfs:label "suprapubic skin specimen" ;
  rdfs:comment "A specimen that is derived from suprapubic skin." ;
  rdfs:subClassOf obo:OBI_0002526 .

obo:IAO_0000618 a rdfs:Class ;
  rdfs:label "consent section"@en ;
  rdfs:comment "A part of a document about the consent process that was used to enroll patients in a study."@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:NGBO_6000377 a rdfs:Class ;
  rdfs:label "BWA assembly process"@en ;
  rdfs:comment "Bioinformatics analysis which performs gapped alignment for single-end reads, supports paired-end mapping, generates mapping quality, and gives multiple hits if required" ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:OBIB_0000309 a rdfs:Class ;
  rdfs:label "FFPE tissue paraffin embedding SOP" ;
  rdfs:comment "A standard operating procedure for the paraffin embedding of a formalin-fixed paraffin-embedded (FFPE) tissue." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:OMIABIS_0000039 a rdfs:Class ;
  rdfs:label "name of sample collection or study contact person"@en ;
  rdfs:comment "A personal name that designates the person acting as contact for a sample collection or a study."@en ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:NGBO_6000218 a rdfs:Class ;
  rdfs:label "multiple sequence alignment"@en ;
  rdfs:comment "A multiple sequence alignment (MSA) is a sequence alignment of three or more biological sequences, generally protein, DNA, or RNA." ;
  rdfs:subClassOf obo:OBI_0002567 .

obo:OBI_0002507 a rdfs:Class ;
  rdfs:label "saliva specimen" ;
  rdfs:comment "A specimen that is derived from saliva." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000338 a rdfs:Class ;
  rdfs:label "drawing a conclusion based on data"@en ;
  rdfs:comment "A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion"@en ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:NGBO_6000258 a rdfs:Class ;
  rdfs:label "sample derivative from specimen creation process"@en ;
  rdfs:comment "A material processing that has as its input a specimen and as its output a sample derivative." ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:CL_0000878 a rdfs:Class ;
  rdfs:label "central nervous system macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:CL_0000669 a rdfs:Class ;
  rdfs:label "pericyte" ;
  rdfs:comment """*Slender, contractile, mesenchymal-like cell found in close association with capillary walls. They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. (From OBO Cell Type Ontology).

*A flattened, or elongated, stellate-shaped solitary cell with multiple cytoplasmic processes encircling the capillary endothelium and contacting a large abluminal vessel area.  It may be equivalent to the vascular smooth muscle cell, although this identify has not been conclusively determined yet  (Armulik et al., Circ Res 97: 512, 2005).""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000199 a rdfs:Class ;
  rdfs:label "whole genome sequence data"@en ;
  rdfs:comment "A DNA sequence data which represent the the complete DNA sequence of an organism's genome at a single time"@en ;
  rdfs:subClassOf obo:OBI_0001573 .

obo:OBI_0002518 a rdfs:Class ;
  rdfs:label "prostate gland specimen" ;
  rdfs:comment "A specimen that is derived from prostate gland." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002522 a rdfs:Class ;
  rdfs:label "adrenal gland specimen" ;
  rdfs:comment "A specimen that is derived from adrenal gland." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000482 a rdfs:Class ;
  rdfs:label "normal phase column"@en ;
  rdfs:comment "A normal phase column is a chromatography column in which the stationary phase is more polar than the mobile phase. Its counterpart is the reversed phase column."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OMIABIS_0000028 a rdfs:Class ;
  rdfs:label "ISO 3166-1 alpha-2 code for biobank contact person"@en ;
  rdfs:comment "The ISO 3166-1 alpha-2 code that is part of the biobank contact person's postal address."@en ;
  rdfs:subClassOf obo:OMIABIS_0000004 .

obo:OBI_0200091 a rdfs:Class ;
  rdfs:label "inter-rater reliability objective"@en ;
  rdfs:comment "a data transformation objective of determining the concordance or agreement between human judges." ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBIB_0000499 a rdfs:Class ;
  rdfs:label "time since radiation therapy was received prior to surgery" ;
  rdfs:comment "A time measurement datum that is the result of measuring the time elapsed since radiation therapy prior to surgery." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:BFO_0000026 a rdfs:Class ;
  rdfs:label "one-dimensional spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000006 .

obo:OBI_0000232 a rdfs:Class ;
  rdfs:label "hardware optimization objective"@en ;
  rdfs:comment "Hardware_optimization is a hardware_testing_objective describing a study designed to identify the best hardware."@en ;
  rdfs:subClassOf obo:OBI_0000134 .

obo:NCBITaxon_9606 a rdfs:Class ;
  rdfs:label "Homo sapiens" ;
  rdfs:subClassOf obo:NCBITaxon_314146 .

obo:OBI_0002027 a rdfs:Class ;
  rdfs:label "Genome Analyzer IIe" ;
  rdfs:comment "An Illumina Genome Analyzer II which is manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology. The Genome Analyzer IIe makes industry-leading next-generation sequencing technology accessible to more laboratories." ;
  rdfs:subClassOf obo:OBI_0000703 .

obo:OBIB_0000246 a rdfs:Class ;
  rdfs:label "name of person storing specimen" ;
  rdfs:comment "A personal name that designates the person who stored a specimen." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001849 a rdfs:Class ;
  rdfs:label "structural analysis by paired-end tag sequencing assay" ;
  rdfs:comment "An assay that incorporates Paired-End Tags and sequencing technology to determine structural variants." ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0600038 a rdfs:Class ;
  rdfs:label "addition of molecular label"@en ;
  rdfs:comment "a material processing technique intended to add a molecular label to some input material entity, to allow detection of the molecular target of this label in a detection of molecular label assay"@en ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:CL_0000235 a rdfs:Class ;
  rdfs:label "macrophage" ;
  rdfs:comment "Relatively long-lived phagocytic cell of mammalian tissues, derived from blood monocyte. Macrophages from different sites have distinctly different properties. Main types are peritoneal and alveolar macrophages, tissue macrophages (histiocytes), Kuppfer cells of the liver, and osteoclasts. In response to foreign materials may become stimulated or activated. Macrophages play an important role in killing of some bacteria, protozoa, and tumour cells, release substances that stimulate other cells of the immune system, and are involved in antigen presentation. May further differentiate within chronic inflammatory lesions to epithelioid cells or may fuse to form foreign body giant cells or Langhans' giant cells." ;
  rdfs:subClassOf obo:CL_0000766 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0600049 a rdfs:Class ;
  rdfs:label "DNA polymerase amplification"@en ;
  rdfs:comment "DNA polymerase amplification is an enzymatic amplification which uses DNA polymerase enzyme to make copies of a DNA contained in biomaterial used as input"@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBI_0000260 a rdfs:Class ;
  rdfs:label "plan"@en ;
  rdfs:comment "A plan is a realizable entity that is the inheres in a bearer who is committed to realizing it as a planned process."@en ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:CL_0000835 a rdfs:Class ;
  rdfs:label "myeloblast" ;
  rdfs:subClassOf obo:CL_0002191 .

obo:CL_0002155 a rdfs:Class ;
  rdfs:label "echinocyte" ;
  rdfs:subClassOf obo:CL_0000595 .

obo:IAO_0000592 a rdfs:Class ;
  rdfs:label "software module"@en ;
  rdfs:comment " A software module is software composed of a collection of software methods."@en ;
  rdfs:subClassOf obo:IAO_0000010 .

obo:OBI_0000051 a rdfs:Class ;
  rdfs:label "liquid chromatography mass spectrometry platform"@en ;
  rdfs:comment "A liquid chromatography mass spectrometry platform is a platform that is the collection of instrument, software and reagents needed to perform a liquid chromatography mass spectrometry protocol. definition_source: OBI."@en ;
  rdfs:subClassOf obo:OBI_0000832 , obo:OBI_0000932 .

obo:BTO_0001130 a rdfs:Class ;
  rdfs:label "prostate gland cancer cell" ;
  rdfs:comment """
A malignant tumour cell of glandular origin in the prostate. Over 95% are adenocarcinomas.
""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0005934> .

obo:CL_0000876 a rdfs:Class ;
  rdfs:label "splenic white pulp macrophage" ;
  rdfs:subClassOf obo:CL_0000871 .

obo:CL_0000787 a rdfs:Class ;
  rdfs:label "memory B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:OBI_0000399 a rdfs:Class ;
  rdfs:label "solid support function"@en ;
  rdfs:comment "A solid support function is a function of a device on which an entity is kept in a defined position and prevented in its movement"@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0400170 a rdfs:Class ;
  rdfs:label "microscope slide"@en ;
  rdfs:comment "a microscope slide is a device usually made of glass which is used as a solid matrix for (biological) material deposited on its surface and which is compatible for use with a microscope instrument"@en ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:OBIB_0000258 a rdfs:Class ;
  rdfs:label "name of person transferring blood plasma specimens to freezer" ;
  rdfs:comment "A personal name that designates the person who transferred blood plasma specimens to freezer." ;
  rdfs:subClassOf obo:IAO_0020015 .

<http://semanticscience.org/resource/SIO_000785> a rdfs:Class ;
  rdfs:label "answer"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000136> .

obo:OBI_0000535 a rdfs:Class ;
  rdfs:label "gel filtration column"@en ;
  rdfs:comment "A Gel filtration column is a chromatography column for size-exclusion chromatography, in which the stationary phase is a gel. The main application of gel filtration chromatography is the fractionation of proteins and other water-soluble polymers."@en ;
  rdfs:subClassOf obo:OBI_0000618 .

<http://semanticscience.org/resource/SIO_001383> a rdfs:Class ;
  rdfs:label "gene symbol"@en ;
  rdfs:comment "a gene symbol is a short name assigned to a gene."@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000120> .

obo:OBI_0000845 a rdfs:Class ;
  rdfs:label "primary structure of RNA molecule" ;
  rdfs:comment "The primary structure of an RNA molecule that is completely defined by the set of its nucleic residue parts and the linear order induced by the peptide bonds that hold them together" ;
  rdfs:subClassOf obo:SO_0000001 .

obo:CL_0001011 a rdfs:Class ;
  rdfs:label "immature interstitial dendritic cell" ;
  rdfs:subClassOf obo:CL_0001007 .

obo:CL_0000015 a rdfs:Class ;
  rdfs:label "male germ cell" ;
  rdfs:subClassOf obo:CL_0000586 .

obo:BTO_0001903 a rdfs:Class ;
  rdfs:label "logarithmic phase culture"@en ;
  rdfs:comment "A cell culture at the steepest slope of the growth curve of a culture-- at the phase of vigorous growth during which cell number doubles every 20-30 minutes." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0002958> .

obo:OBI_0002004 a rdfs:Class ;
  rdfs:label "Methylation 450K BeadChip" ;
  rdfs:comment "A methylation BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array interrogates ~ 485,000 methylation sites per sample at single-nucleotide resolution." ;
  rdfs:subClassOf obo:OBI_0001870 .

obo:CL_0000999 a rdfs:Class ;
  rdfs:label "CD4-positive CD11b-positive dendritic cell" ;
  rdfs:subClassOf obo:CL_0002465 .

<http://www.ebi.ac.uk/efo/EFO_0000586> a rdfs:Class ;
  rdfs:label "mesenchymal stem cell" ;
  rdfs:subClassOf obo:CL_0000034 .

obo:NGBO_6000058 a rdfs:Class ;
  rdfs:label "reference genome URI"@en ;
  rdfs:comment "A reference genome datum which represent a location where reference genome can be accessed online" ;
  rdfs:subClassOf obo:NGBO_6000244 , <http://semanticscience.org/resource/SIO_000811> .

obo:IAO_0000088 a rdfs:Class ;
  rdfs:label "report"@en ;
  rdfs:comment "a document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record)"@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:CL_0000871 a rdfs:Class ;
  rdfs:label "splenic macrophage" ;
  rdfs:subClassOf obo:CL_0000867 .

obo:CL_0000988 a rdfs:Class ;
  rdfs:label "hematopoietic cell" ;
  rdfs:comment "A cell found predominately in the blood." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000948 a rdfs:Class ;
  rdfs:label "IgE memory B cell" ;
  rdfs:subClassOf obo:CL_0000972 .

obo:CL_0000770 a rdfs:Class ;
  rdfs:label "band form basophil" ;
  rdfs:subClassOf obo:CL_0000768 .

obo:OBI_0200188 a rdfs:Class ;
  rdfs:label "cross validation objective"@en ;
  rdfs:comment "A cross validation objective is a data transformation objective in which the aim is to partition a sample of data into subsets such that the analysis is initially performed on a single subset, while the other subset(s) are retained for subsequent use in confirming and validating the initial analysis."@en ;
  rdfs:subClassOf obo:OBI_0200172 .

obo:OBI_0001924 a rdfs:Class ;
  rdfs:label "micrococcal nuclease digestion followed by high throughput sequencing assay" ;
  rdfs:comment "An assay that identifies nucleosome positioning by genome wide sequencing of regions sensitive to digestion by micrococal nuclease" ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:BTO_0004578 a rdfs:Class ;
  rdfs:label "vascular smooth muscle cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000627 a rdfs:Class ;
  rdfs:label "target enrichment kit"@en ;
  rdfs:comment "An assay kit used for the technique of target enrichment" ;
  rdfs:subClassOf obo:NGBO_6000236 .

obo:CL_0000556 a rdfs:Class ;
  rdfs:label "megakaryocyte" ;
  rdfs:comment "A large cell that has a lobulated nucleus, is found especially in the bone marrow, and is the source of blood platelets." ;
  rdfs:subClassOf obo:CL_0000763 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002365 a rdfs:Class ;
  rdfs:label "medullary thymic epithelial cell" ;
  rdfs:comment "An epithelial cell located in the inner portion of the thymus where the T lymphocytes become mature and are released into the circulation." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002370 a rdfs:Class ;
  rdfs:label "unknown clinical history of cancer" ;
  rdfs:comment "A clinical history in which it is not known whether there was a diagnosis of cancer." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0001674 a rdfs:Class ;
  rdfs:label "cap analysis of gene expression assay" ;
  rdfs:comment "A transcription profiling assay which measures RNA transcript abundances in biological samples by extracting 5' ends of capped transcripts, RTPCR and sequence those. Copy numbers of CAGE tags provide a way of quantification and provide a measure of expression of the transcriptome" ;
  rdfs:subClassOf obo:OBI_0000424 , obo:OBI_0600047 .

obo:CL_0002275 a rdfs:Class ;
  rdfs:label "pancreatic PP cell" ;
  rdfs:comment "A PP cell located in the islets of the pancreas." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0002966> .

obo:OBI_0000606 a rdfs:Class ;
  rdfs:label "open tubular column"@en ;
  rdfs:comment "An open tubular column is a chromatography column in which the particles of the solid stationary phase or the support coated with a liquid stationary phase are concentrated on or along the inside tube wall leaving an open, unrestricted path for the mobile phase in the middle part of the tube."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CL_0002510 a rdfs:Class ;
  rdfs:label "CD103-negative, langerin-positive lymph node dendritic cell" ;
  rdfs:subClassOf obo:CL_0002507 .

obo:CL_0000580 a rdfs:Class ;
  rdfs:label "neutrophilic myelocyte" ;
  rdfs:subClassOf obo:CL_0000776 , obo:CL_0002193 .

obo:OBI_0000424 a rdfs:Class ;
  rdfs:label "transcription profiling assay" ;
  rdfs:comment "An assay that determines gene expression and transcription activity using ribonucleic acids collected from a material entity." ;
  rdfs:subClassOf obo:NGBO_6000353 , obo:OBI_0000070 .

obo:CL_0000187 a rdfs:Class ;
  rdfs:label "muscle cell" ;
  rdfs:comment "A mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000390 a rdfs:Class ;
  rdfs:label "blood cell (sensu Nematoda and Protostomia)" ;
  rdfs:subClassOf obo:CL_0000081 .

obo:OBI_0001479 a rdfs:Class ;
  rdfs:label "specimen from organism"@en ;
  rdfs:comment "A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm)." ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0002623 a rdfs:Class ;
  rdfs:label "whole metagenome sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that intends to provide information on the DNA sequences of multiple genomes (a metagenome) from different organisms present in the same input sample." ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:BFO_0000004 a rdfs:Class ;
  rdfs:label "independent continuant"@en ;
  rdfs:comment "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:CL_0000982 a rdfs:Class ;
  rdfs:label "IgG plasmablast" ;
  rdfs:subClassOf obo:CL_0000980 .

obo:OBI_0001909 a rdfs:Class ;
  rdfs:label "conclusion based on data" ;
  rdfs:comment "An information content entity that is inferred from data." ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:CL_0002462 a rdfs:Class ;
  rdfs:label "adipose dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:PO_0020132 a rdfs:Class ;
  rdfs:label "columella root cap cell" ;
  rdfs:comment "Cell that constitutes the central part of the root cap, arranged in longitudinal files." ;
  rdfs:subClassOf obo:PO_0025606 .

obo:BFO_0000146 a rdfs:Class ;
  rdfs:label "two-dimensional continuant fiat boundary"@en ;
  rdfs:subClassOf obo:BFO_0000140 .

obo:OBI_0000423 a rdfs:Class ;
  rdfs:label "extract"@en ;
  rdfs:comment "an extract is a material entity which results from an extraction process"@en ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:NGBO_6000185 a rdfs:Class ;
  rdfs:label "Allele-specific expression data"@en ;
  rdfs:comment "A measured expression level which refers to the characteristic of preferentially expressing a parental allele in the hybrid due to variations in regulatory sequences from the parental genomes." ;
  rdfs:subClassOf obo:OBI_0000101 .

obo:OBI_0000405 a rdfs:Class ;
  rdfs:label "primer role"@en ;
  rdfs:comment "a complementary nucleotide probe role which inheres in nucleic acid molecular entity and is realized by the use of the entity bearing the role to initiate chain elongation." ;
  rdfs:subClassOf obo:OBI_0000857 .

obo:OBI_0000736 a rdfs:Class ;
  rdfs:label "single fragment library" ;
  rdfs:comment "is a collection of short tags from DNA fragments, are extracted and covalently linked as single tag constructs" ;
  rdfs:subClassOf obo:OBI_0000047 .

<http://www.ebi.ac.uk/efo/EFO_0004039> a rdfs:Class ;
  rdfs:label "mouse neural progenitor cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:BFO_0000015 a rdfs:Class ;
  rdfs:label "process"@en ;
  rdfs:comment "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:OBIB_0000086 a rdfs:Class ;
  rdfs:label "specimen collected with specific collection packet" ;
  rdfs:comment "A specimen from organism that is collected with a collection packet that is designed to collect specimens of a particular type for a particular purpose." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0400147 a rdfs:Class ;
  rdfs:label "microarray"@en ;
  rdfs:comment "A processed material that is made to be used in an analyte assay. It consists of a physical immobilisation matrix in which substances that bind the analyte are placed in regular spatial position."@en ;
  rdfs:subClassOf obo:OBI_0001865 .

<http://www.ebi.ac.uk/efo/EFO_0002962> a rdfs:Class ;
  rdfs:label "animal reproductive system cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002021 a rdfs:Class ;
  rdfs:label "GlyA-positive erythrocyte" ;
  rdfs:subClassOf obo:CL_0000595 .

obo:NCBITaxon_33154 a rdfs:Class ;
  rdfs:label "Opisthokonta" ;
  rdfs:subClassOf obo:NCBITaxon_2759 .

obo:OMIABIS_0001079 a rdfs:Class ;
  rdfs:label "specimen donor"@en ;
  rdfs:comment "A Homo sapiens who contributes specimen." ;
  rdfs:subClassOf obo:NCBITaxon_9606 .

obo:OBI_0000609 a rdfs:Class ;
  rdfs:label "glass column"@en ;
  rdfs:comment "A glass column is a chromatography column made out of glass that is usually used for larger scale and preparative liquid chromatography separations."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CL_0000865 a rdfs:Class ;
  rdfs:label "gastrointestinal tract (lamina propria) macrophage" ;
  rdfs:subClassOf obo:CL_0000885 .

obo:ICO_0000058 a rdfs:Class ;
  rdfs:label "informed consented study period"@en ;
  rdfs:comment "a one-dimensional temporal region that is a period of an informed consented study" ;
  rdfs:subClassOf obo:BFO_0000038 .

obo:CL_0000094 a rdfs:Class ;
  rdfs:label "granulocyte" ;
  rdfs:comment "A leukocyte with abundant granules in the cytoplasm." ;
  rdfs:subClassOf obo:CL_0000766 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0001007 a rdfs:Class ;
  rdfs:label "interstitial dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:CL_0001022 a rdfs:Class ;
  rdfs:label "CD115-positive monocyte" ;
  rdfs:subClassOf obo:CL_0000576 .

obo:OBIB_0000202 a rdfs:Class ;
  rdfs:label "name of biobank person receiving specimen" ;
  rdfs:comment "A personal name that designates the person who received a specimen in the biobank." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0000848 a rdfs:Class ;
  rdfs:label "polyA RNA extraction" ;
  rdfs:comment "A RNA extraction process typically involving the use of poly dT oligomers in which the desired output material is polyA RNA." ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBI_0000636 a rdfs:Class ;
  rdfs:label "acquisition computer"@en ;
  rdfs:comment "A Computer used for NMR, can be divided into central processing unit (CPU), consisting of instruction, interpretation and arithmetic unit plus fast access memory, and peripheral devices such as bulk data storage and input and output devices (including, via the interface, the spectrometer). Under software control, the computer controls the RF pulses and gradients necessary to acquire data, and process the data to produce spectra or images. Note that devices such as the spectrometer may themselves incorporate small computers."@en ;
  rdfs:subClassOf obo:OBI_0400107 .

obo:NGBO_6000685 a rdfs:Class ;
  rdfs:label "bioinformatics pipeline"@en ;
  rdfs:comment "A software pipeline that is composed of a wide array of software algorithms to process biological raw data." ;
  rdfs:subClassOf obo:OBI_0001943 .

obo:OBI_0002469 a rdfs:Class ;
  rdfs:label "base calling application"@en ;
  rdfs:comment "A base-calling application that implments a base-calling algorithm to convert BCL (binary base call) files, (e.g., those generated by Illumina sequencing systems) to standard FASTQ file formats for downstream analysis."@en ;
  rdfs:subClassOf obo:IAO_0000594 .

obo:CL_0000560 a rdfs:Class ;
  rdfs:label "band form neutrophil" ;
  rdfs:subClassOf obo:CL_0000776 .

obo:CL_0002087 a rdfs:Class ;
  rdfs:label "nongranular leukocyte" ;
  rdfs:subClassOf obo:CL_0000738 .

obo:NGBO_6000207 a rdfs:Class ;
  rdfs:label "variant prioritisation"@en ;
  rdfs:comment "A genetic variation analysis which involves identifying biologically interesting variants by prioritizing individual variants, for example, homozygous variants absent in control genomes." ;
  rdfs:subClassOf obo:NGBO_6000261 .

obo:OBI_0000722 a rdfs:Class ;
  rdfs:label "paired-end library" ;
  rdfs:comment "is a collection of short paired tags from the two ends of DNA fragments are extracted and covalently linked as ditag constructs" ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:OMIABIS_0000024 a rdfs:Class ;
  rdfs:label "post-office box"@en ;
  rdfs:comment "A post-office box is material entity that is a box on the premises of a post office station and is uniquely addressable."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:NGBO_6000303 a rdfs:Class ;
  rdfs:label "pathogenic variant"@en ;
  rdfs:comment "A clinical variant interpretation that represents a sequence variant that is previously reported and is a recognized cause of the disorder." ;
  rdfs:subClassOf obo:NGBO_6000302 .

obo:NGBO_6000286 a rdfs:Class ;
  rdfs:label "specimen tracking protocol"@en ;
  rdfs:comment "A protocol that ensure that biospecimens can be tracked accurately from the collection site through biospecimen arrival and subsequent" ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:OBI_0200177 a rdfs:Class ;
  rdfs:label "center calculation objective"@en ;
  rdfs:comment "A center calculation objective is a data transformation objective where the aim is to calculate the center of an input data set."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002540 a rdfs:Class ;
  rdfs:label "coronary artery specimen" ;
  rdfs:comment "A specimen that is derived from coronary artery." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000785 a rdfs:Class ;
  rdfs:label "mature B cell" ;
  rdfs:comment "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." ;
  rdfs:subClassOf obo:CL_0000236 .

obo:OBI_0000691 a rdfs:Class ;
  rdfs:label "ABI 377 automated sequencer" ;
  rdfs:comment "is a DNA sequencer which is manufactured by Applied Biosystems corporation (formerly Perkin-Elmer). It allows automated chain termination DNA sequencing. It has part polyacrylamide gel electrophoresis system and a laser -based detection system to detect fluorescence intensity emitted by the dyes attached to the dideoxyterminator nucleotides or to the primers." ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:NGBO_6000359 a rdfs:Class ;
  rdfs:label "Burrows-Wheeler Aligner algorithm"@en ;
  rdfs:comment "An algorithm which perform mapping of low-divergent sequences against a large reference genome, such as the human genome." ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0200166 a rdfs:Class ;
  rdfs:label "data transformation objective"@en ;
  rdfs:comment "An objective specification to transformation input data into output data"@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:IAO_0000029 a rdfs:Class ;
  rdfs:label "numeral"@en ;
  rdfs:comment "A symbol that denotes a number."@en ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:CL_0000128 a rdfs:Class ;
  rdfs:label "oligodendrocyte" ;
  rdfs:comment "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002527 a rdfs:Class ;
  rdfs:label "pancreas specimen" ;
  rdfs:comment "A specimen that is derived from pancreas." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001626 a rdfs:Class ;
  rdfs:label "Bioinformatics Resource Center"@en ;
  rdfs:comment "An organization that  is one of the Internet-based research centers established and funded by NIAID (the National Institute of Allergy and Infectious Diseases). The Bioinformatics Resource Centers (BRCs) were formed in response to the threats posed by emerging and re-emerging pathogens, particularly CDC Category A, B, and C pathogens, and their potential use in bioterrorism. The intention of NIAID in funding these bioinformatics centers is to assist researchers involved in the experimental characterization of such pathogens and the formation of drugs, vaccines, or diagnostic tools to combat them."@en ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:CL_0000887 a rdfs:Class ;
  rdfs:label "lymph node subcapsular sinus macrophage" ;
  rdfs:subClassOf obo:CL_0000868 .

obo:CL_0002010 a rdfs:Class ;
  rdfs:label "pre-conventional dendritic cell" ;
  rdfs:subClassOf obo:CL_0002031 .

obo:OBIB_0000068 a rdfs:Class ;
  rdfs:label "collection packet identifier" ;
  rdfs:comment "An identifier that refers to a collection packet used in a specimen collection process." ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:DOID_162 a rdfs:Class ;
  rdfs:label "cancer" ;
  rdfs:comment "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." ;
  rdfs:subClassOf obo:OGMS_0000031 .

obo:RO_0004023 a rdf:Property ;
  rdfs:label "causal relationship with disease as subject" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0040035 , obo:RO_0002410 .

obo:RO_0004026 a rdf:Property ;
  rdfs:label "disease has location" ;
  rdfs:comment "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0040035 .

obo:RO_0004022 a rdf:Property ;
  rdfs:label "disease has basis in feature" ;
  rdfs:comment "A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0004019 , obo:RO_0002200 .

obo:RO_0004019 a rdf:Property ;
  rdfs:label "disease has basis in" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0004023 , obo:RO_0004017 .

obo:RO_0004025 a rdf:Property ;
  rdfs:label "disease causes dysfunction of" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004024 a rdf:Property ;
  rdfs:label "disease causes disruption of" ;
  rdfs:comment "A relationship between a disease and a process where the disease process disrupts the execution of the process." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004027 a rdf:Property ;
  rdfs:label "disease has inflammation site" ;
  rdfs:comment "A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range obo:BFO_0000004 ;
  rdfs:subPropertyOf obo:RO_0004026 .

obo:RO_0004029 a rdf:Property ;
  rdfs:label "disease has feature" ;
  rdfs:comment "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0040035 .

obo:RO_0002452 a rdf:Property ;
  rdfs:label "has symptom" ;
  rdfs:comment "A relation that holds between a disease or an organism and a phenotype" ;
  rdfs:domain obo:OGMS_0000031 ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf obo:RO_0002200 .

obo:BFO_0000009 a rdfs:Class ;
  rdfs:label "two-dimensional spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000006 .

obo:OBI_0000696 a rdfs:Class ;
  rdfs:label "AB SOLiD System" ;
  rdfs:comment "is a DNA sequencer which is manufactured by Applied Biosystems and which enable DNA sequencing by ligation" ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0001853 a rdfs:Class ;
  rdfs:label "DNase I hypersensitive sites sequencing assay" ;
  rdfs:comment "An assay that identifies the location of regulatory regions, based on the genome-wide sequencing of regions super sensitive to cleavage by DNase I." ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:NGBO_6000319 a rdfs:Class ;
  rdfs:label "messenger RNA sequence data"@en ;
  rdfs:comment "RNA sequence data that represent the sequence of single-stranded RNA molecule that is complementary to one of the DNA strands of a gene. The mRNA is an RNA version of the gene that leaves the cell nucleus and moves to the cytoplasm where proteins are made."@en ;
  rdfs:subClassOf obo:OBIws_0000192 .

obo:OBI_0002567 a rdfs:Class ;
  rdfs:label "sequence alignment" ;
  rdfs:comment "A data transformation in which one or more sequences (reads) are positioned on a reference sequence template (often a reference set of genes), according to the genetic base-pairing paradigm." ;
  rdfs:subClassOf obo:NGBO_6000179 .

obo:CL_0000882 a rdfs:Class ;
  rdfs:label "thymic medullary macrophage" ;
  rdfs:subClassOf obo:CL_0000866 .

obo:CL_0002355 a rdfs:Class ;
  rdfs:label "primitive red blood cell" ;
  rdfs:subClassOf obo:CL_0002417 .

obo:OBIB_0000548 a rdfs:Class ;
  rdfs:label "clinical history of abnormal white blood cell levels" ;
  rdfs:comment "A clinical history in which there is a history of abnormal white blood cell levels." ;
  rdfs:subClassOf obo:OGMS_0000015 .

<http://www.ebi.ac.uk/efo/EFO_0005497> a rdfs:Class ;
  rdfs:label "pharyngeal muscle cell" ;
  rdfs:comment "type of cells that make up muscle layers in the pharynx in worms such as C. elegans" ;
  rdfs:subClassOf obo:CL_0000187 .

obo:BFO_0000028 a rdfs:Class ;
  rdfs:label "three-dimensional spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000006 .

obo:CHEBI_23367 a rdfs:Class ;
  rdfs:label "molecular entity" ;
  rdfs:comment "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:BTO_0000551 a rdfs:Class ;
  rdfs:label "lung cancer cell" ;
  rdfs:comment "Cancer cell of the major organ of respiration the lung." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

<http://www.ebi.ac.uk/efo/EFO_1001464> a rdfs:Class ;
  rdfs:label "glial brain cell"@en ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002474 a rdfs:Class ;
  rdfs:label "lymphoid MHC-II-negative classical monocyte" ;
  rdfs:subClassOf obo:CL_0002469 .

obo:OBIB_0000288 a rdfs:Class ;
  rdfs:label "FFPE tissue processing SOP" ;
  rdfs:comment "A standard operating procedure for fixation of a tissue to the state where it is completely infiltrated with a suitable histological wax and can be embedded ready for section cutting on the microtome for a formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:CL_0000138 a rdfs:Class ;
  rdfs:label "chondrocyte" ;
  rdfs:comment "Polymorphic cell that form cartilage." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002009 a rdfs:Class ;
  rdfs:label "macrophage dendritic cell progenitor" ;
  rdfs:subClassOf obo:CL_0002032 .

<http://semanticscience.org/resource/SIO_000078> a rdfs:Class ;
  rdfs:label "language entity"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OMIABIS_0000911 a rdfs:Class ;
  rdfs:label "fixation"@en ;
  rdfs:comment "A material processing that uses chemical process by which biological tissues are preserved from decay. Fixation terminates any ongoing biochemical reactions and may increase stability of the treated tissues. "@en ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:OBIB_0000501 a rdfs:Class ;
  rdfs:label "time since immunotherapy was received prior to surgery" ;
  rdfs:comment "A time measurement datum that is the result of measuring the time elapsed since immunotherapy prior to surgery." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:NGBO_6000236 a rdfs:Class ;
  rdfs:label "assay kit"@en ;
  rdfs:comment "A processed material which contain a set of articles or equipment needed for a specific purpose." ;
  rdfs:subClassOf obo:OBI_0000047 .

obo:CL_0000971 a rdfs:Class ;
  rdfs:label "IgM memory B cell" ;
  rdfs:subClassOf obo:CL_0000970 .

<http://www.ebi.ac.uk/efo/EFO_0004953> a rdfs:Class ;
  rdfs:label "date of diagnosis"@en ;
  rdfs:comment "The point at which a clinical diagnosis is made." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBIB_0000389 a rdfs:Class ;
  rdfs:label "name of reviewer of pathology case summary report." ;
  rdfs:comment "A personal name that designates the person who served as the reviewer for quality assurance purposes of a pathology case summary report." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0002500 a rdfs:Class ;
  rdfs:label "amniotic fluid specimen" ;
  rdfs:comment "A specimen that is derived from amniotic fluid." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:ICO_0000126 a rdfs:Class ;
  rdfs:label "storage duration of signed informed consent form" ;
  rdfs:comment "a termporal interval that represents a period of time during which a signed informed consent form is stored." ;
  rdfs:subClassOf obo:BFO_0000038 .

obo:CL_0001029 a rdfs:Class ;
  rdfs:label "common dendritic progenitor" ;
  rdfs:subClassOf obo:CL_0002031 .

obo:OBIB_0000601 a rdfs:Class ;
  rdfs:label "clinical history of dementia of unknown cause" ;
  rdfs:comment "A clinical history in which there is a history of dementia with unknown cause  that is not caused by a previous Cerebrovascular Accident (CVA) infection, head trauma or brain tumor)." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002049 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 4000" ;
  rdfs:comment "A DNA sequencer manufactured by Illumina corporation, with two flow cell and a throughput of more than 400 Gb per day." ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:CL_0000765 a rdfs:Class ;
  rdfs:label "erythroblast" ;
  rdfs:comment "A nucleated precursor of an erythrocyte." ;
  rdfs:subClassOf obo:CL_0000764 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NCIT_C25690 a rdfs:Class ;
  rdfs:label "Street Address" ;
  rdfs:comment "The street name and building number where a person or organization can be found." ;
  rdfs:subClassOf <http://www.w3.org/2006/vcard/ns#Address> .

obo:OBIB_0000275 a rdfs:Class ;
  rdfs:label "name of IATA-trained person verifying specimen transport" ;
  rdfs:comment "A personal name that designates the person who verified the specimen transport was according to best practice, international standards, and industry regulations as trained by the IATA." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:NGBO_6000014 a rdfs:Class ;
  rdfs:label "bed graph format"@en ;
  rdfs:comment "A file format which represent a data format allows display of continuous-valued data in track format" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:CL_0000867 a rdfs:Class ;
  rdfs:label "secondary lymphoid organ macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:CL_0002358 a rdfs:Class ;
  rdfs:label "pyrenocyte" ;
  rdfs:subClassOf obo:CL_0002417 .

obo:CL_0002026 a rdfs:Class ;
  rdfs:label "CD34-negative, CD41-positive, CD42-positive megakaryocyte cell" ;
  rdfs:subClassOf obo:CL_0000556 .

obo:CL_0002456 a rdfs:Class ;
  rdfs:label "CD8_alpha-positive plasmactyoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000989 .

obo:CL_0000993 a rdfs:Class ;
  rdfs:label "mature CD11c-low plasmacytoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000989 .

obo:OBIB_0000285 a rdfs:Class ;
  rdfs:label "name of quality control inspector of specimen" ;
  rdfs:comment "A personal name that designates the person who performed a quality control inspection of the specimen that is to be transported to another organization." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0000468 a rdfs:Class ;
  rdfs:label "protein column"@en ;
  rdfs:comment "A protein column is a chromatography column used for the separation of complex protein mixtures. Protein columns enable sample desalting, followed by chromatographic separation or fractionation of complex protein samples, e.g. immunodepleted serum or plasma proteins."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0001691 a rdfs:Class ;
  rdfs:label "cellular structure feature identification objective"@en ;
  rdfs:comment "is an objective specification which aims to discover cellular structure properties"@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:CL_0000776 a rdfs:Class ;
  rdfs:label "immature neutrophil" ;
  rdfs:subClassOf obo:CL_0000775 .

obo:OBIB_0000543 a rdfs:Class ;
  rdfs:label "clinical history of sepsis" ;
  rdfs:comment "A clinical history in which there is a history of sepsis." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002487 a rdfs:Class ;
  rdfs:label "microraft"@en ;
  rdfs:comment "A material separation device also commerically known as Isoraft, that is used to isolate single cells."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:CL_0000218 a rdfs:Class ;
  rdfs:label "Schwann cell" ;
  rdfs:comment "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000723 a rdfs:Class ;
  rdfs:label "somatic stem cell" ;
  rdfs:comment "A stem cell that can give rise to cell types of the body other than those of the germ-line." ;
  rdfs:subClassOf obo:CL_0000034 , obo:CL_0002371 .

obo:CL_0002321 a rdfs:Class ;
  rdfs:label "embryonic cell" ;
  rdfs:comment "A cell of the embryo." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002368 a rdfs:Class ;
  rdfs:label "respiratory epithelial cell" ;
  rdfs:comment "An endo-epithelial cell of the respiratory tract." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:IAO_0000104 a rdfs:Class ;
  rdfs:label "plan specification"@en ;
  rdfs:comment "A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:BFO_0000142 a rdfs:Class ;
  rdfs:label "one-dimensional continuant fiat boundary"@en ;
  rdfs:subClassOf obo:BFO_0000140 .

obo:CL_0002451 a rdfs:Class ;
  rdfs:label "mammary stem cell" ;
  rdfs:comment "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi. [ PMID:16397499 GOC:tfm PMID:17851544 GOC:hjd PMID:15987436 ] " ;
  rdfs:subClassOf obo:CL_0000034 .

obo:CL_0000501 a rdfs:Class ;
  rdfs:label "granulosa cell" ;
  rdfs:comment "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000474 a rdfs:Class ;
  rdfs:label "data transfer agreement document act"@en ;
  rdfs:comment "A planned process of making the decision of the data transfer." ;
  rdfs:subClassOf obo:OBI_0302908 .

<http://semanticscience.org/resource/SIO_000116> a rdfs:Class ;
  rdfs:label "name"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000179> .

obo:OBI_0000989 a rdfs:Class ;
  rdfs:label "PCR instrument" ;
  rdfs:comment "A device that is used to amplify a single or few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence." ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:OBI_0002369 a rdfs:Class ;
  rdfs:label "clinical history devoid of cancer" ;
  rdfs:comment "A clinical history in which there was no diagnosis of cancer." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBIB_0000602 a rdfs:Class ;
  rdfs:label "clinical history of Multiple Sclerosis" ;
  rdfs:comment "A clinical history in which there is a history of Multiple Sclerosis (MS)." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000355 a rdfs:Class ;
  rdfs:label "ACMG guidelines for classification of variants"@en ;
  rdfs:comment "A protocol which describes the guidance for the interpretation of sequence variants suggested by The American College of Medical Genetics and Genomics (ACMG)."@en ;
  rdfs:subClassOf obo:NGBO_6000354 .

obo:OBI_0002529 a rdfs:Class ;
  rdfs:label "pituitary gland specimen" ;
  rdfs:comment "A specimen that is derived from pituitary gland." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBIB_0000053 a rdfs:Class ;
  rdfs:label "duration time of smoking"@en ;
  rdfs:comment "A time measurement datum about how long a person has been smoking." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBIB_0000286 a rdfs:Class ;
  rdfs:label "name of data entry person for tissue recovery form" ;
  rdfs:comment "A personal name that designates the person who performed the data entry process for filling in a tissue recovery case report form." ;
  rdfs:subClassOf obo:IAO_0020015 .

<http://www.ebi.ac.uk/efo/EFO_0004040> a rdfs:Class ;
  rdfs:label "mouse embryonic fibroblast cell" ;
  rdfs:comment "Mouse embryonic fibroblast cell" ;
  rdfs:subClassOf obo:CL_0000057 .

obo:NGBO_6000265 a rdfs:Class ;
  rdfs:label "allele specific PCR"@en ;
  rdfs:comment "A validation of known variant assay which permits the direct detection of any point mutation in human DNA by analyzing the PCR products in an ethidium bromide-stained agarose or polyacrylamide gel" ;
  rdfs:subClassOf obo:NGBO_6000264 .

obo:NGBO_6000415 a rdfs:Class ;
  rdfs:label "software description"@en ;
  rdfs:comment "Information about software includes software description." ;
  rdfs:subClassOf obo:NGBO_6000409 .

obo:OMRSE_00000012 a rdfs:Class ;
  rdfs:label "health care provider role"@en ;
  rdfs:comment "A human health care role inhering in an organization or human being that is realized by a process of providing health care services to an organism."@en ;
  rdfs:subClassOf obo:OMRSE_00000010 .

obo:RO_0000052 a rdf:Property ;
  rdfs:label "inheres in"@en ;
  rdfs:comment "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:CL_0000830 a rdfs:Class ;
  rdfs:label "basophilic promyelocyte" ;
  rdfs:subClassOf obo:CL_0000836 .

obo:CL_0002466 a rdfs:Class ;
  rdfs:label "small intestine serosal dendritic cell" ;
  rdfs:subClassOf obo:CL_0002465 .

obo:CL_0000766 a rdfs:Class ;
  rdfs:label "myeloid leukocyte" ;
  rdfs:subClassOf obo:CL_0000738 .

obo:NGBO_6000019 a rdfs:Class ;
  rdfs:label "bed format"@en ;
  rdfs:comment "A file format which represent represent format provides a flexible way to define the data lines that are displayed in an annotation track" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:CL_0000764 a rdfs:Class ;
  rdfs:label "erythroid lineage cell" ;
  rdfs:comment "A immature or mature cell in the lineage leading to and including erythrocytes." ;
  rdfs:subClassOf obo:CL_0000763 .

obo:CL_0000371 a rdfs:Class ;
  rdfs:label "protoplast" ;
  rdfs:comment "The cell protoplasm after removal of the cell wall." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:IAO_0000317 a rdfs:Class ;
  rdfs:label "methods section"@en ;
  rdfs:comment "A part of a publication about an investigation that is about the study design of the investigation"@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:NGBO_6000304 a rdfs:Class ;
  rdfs:label "likely pathogenic variant"@en ;
  rdfs:comment "A clinical variant interpretation that represents a sequence variant that is previously unreported and is of the type which is expected to cause the disorder." ;
  rdfs:subClassOf obo:NGBO_6000302 .

obo:OBI_0001942 a rdfs:Class ;
  rdfs:label "grant agency"@en ;
  rdfs:comment "An organization that provides funding support for projects such as investigations." ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:CL_0000236 a rdfs:Class ;
  rdfs:label "B cell" ;
  rdfs:comment "A lymphocyte of B lineage with the phenotype CD19-positive and surface immunoglobulin-positive." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000071 a rdfs:Class ;
  rdfs:label "specimen transport SOP" ;
  rdfs:comment "A standard operating procedure for the transportation of specimens." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:NCIT_C25720 a rdfs:Class ;
  rdfs:label "Zip Code" ;
  rdfs:comment "A system designed to expedite the sorting and delivery of mail by assigning a series of numbers to each delivery area in the United States.  Also used to refer to any individual delivery area code." ;
  rdfs:subClassOf obo:NCIT_C25621 .

obo:NGBO_0000059 a rdfs:Class ;
  rdfs:label "PM2 criteria"@en ;
  rdfs:comment """Absent from controls (or at extremely low frequency if recessive) 
in Exome Sequencing Project, 1000 Genomes or ExAC""" ;
  rdfs:subClassOf obo:NGBO_0000065 .

obo:OBI_0000560 a rdfs:Class ;
  rdfs:label "ion exchange column"@en ;
  rdfs:comment "An ion exchange column is a chromatography column that is used in ion exchange chromatography and anion or cation exchange resins to enable separation."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OMRSE_00000010 a rdfs:Class ;
  rdfs:label "human health care role"@en ;
  rdfs:comment "A role in human social processes that is realized by health care processes such as seeking or providing treatment for disease and injury, diagnosing disease and injury, or undergoing diagnosis. "@en ;
  rdfs:subClassOf obo:OMRSE_00000024 .

obo:BTO_0001899 a rdfs:Class ;
  rdfs:label "stationary phase culture"@en ;
  rdfs:comment "A cell culture at the plateau of the growth curve after log growth in a culture, during which cell number remains constant. New cells are produced at the same rate as older cells die." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0002958> .

obo:OBI_0000011 a rdfs:Class ;
  rdfs:label "planned process"@en ;
  rdfs:comment "A processual entity that realizes a plan which is the concretization of a plan specification."@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBIB_0000597 a rdfs:Class ;
  rdfs:label "clinical history of Reye's Syndrome" ;
  rdfs:comment "A clinical history in which there is a history of Reye's Syndrome." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000042 a rdfs:Class ;
  rdfs:label "neutrophilic myeloblast" ;
  rdfs:subClassOf obo:CL_0000835 .

obo:OBI_0002198 a rdfs:Class ;
  rdfs:label "molecular analysis facility organization"@en ;
  rdfs:comment "An organization that provides molecular analysis service." ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OBI_0200196 a rdfs:Class ;
  rdfs:label "correlation study objective" ;
  rdfs:comment "A data transformation objective in which correlation is obtained (often measured as a correlation coefficient, ρ) which indicates the strength and direction of a relationship between two random variables." ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:BFO_0000008 a rdfs:Class ;
  rdfs:label "temporal region"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:CL_0000883 a rdfs:Class ;
  rdfs:label "thymic cortical macrophage" ;
  rdfs:subClassOf obo:CL_0000866 .

obo:GENEPIO_0001888 a rdfs:Class ;
  rdfs:label "Canada postal code"@en ;
  rdfs:comment "A Canadian postal code is a postal code that pertains to a geographic region of Canada."@en ;
  rdfs:subClassOf obo:NCIT_C25621 .

obo:PO_0030015 a rdfs:Class ;
  rdfs:label "sporophyte meristematic apical cell" ;
  rdfs:comment "A meristematic apical cell that is part of a whole plant in the sporophytic phase." ;
  rdfs:subClassOf obo:PO_0030007 .

obo:OBI_0002478 a rdfs:Class ;
  rdfs:label "reference genome-transcriptome alignment algorithm"@en ;
  rdfs:comment "An algorithm that attempts to align a nucleic acid sequence to a reference genome and transcriptome."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0002510 a rdfs:Class ;
  rdfs:label "synovial fluid specimen" ;
  rdfs:comment "A specimen that is derived from synovial fluid." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000477 a rdfs:Class ;
  rdfs:label "follicle cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000286 a rdfs:Class ;
  rdfs:label "hyphal cell" ;
  rdfs:comment "A cell of a filament of a fungal mycelium." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000975 a rdfs:Class ;
  rdfs:label "short lived plasma cell" ;
  rdfs:subClassOf obo:CL_0000786 .

obo:OBI_0002535 a rdfs:Class ;
  rdfs:label "esophagus muscularis mucosa specimen" ;
  rdfs:comment "A specimen that is derived from esophagus muscularis mucosa." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:IAO_0000033 a rdfs:Class ;
  rdfs:label "directive information entity"@en ;
  rdfs:comment "An information content entity whose concretizations indicate to their bearer how to realize them in a process."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBIB_0000560 a rdfs:Class ;
  rdfs:label "clinical history of tuberculosis" ;
  rdfs:comment "A clinical history in which there is a history of tuberculosis ." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0002467 a rdfs:Class ;
  rdfs:label "Gr1-high myeloid suppressor cell" ;
  rdfs:subClassOf obo:CL_0000889 .

obo:CL_0000062 a rdfs:Class ;
  rdfs:label "osteoblast" ;
  rdfs:comment "A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:BFO_0000002 a rdfs:Class ;
  rdfs:label "continuant"@en ;
  rdfs:comment "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ;
  rdfs:subClassOf obo:BFO_0000001 .

obo:OBI_1110095 a rdfs:Class ;
  rdfs:label "blood harvesting"@en ;
  rdfs:comment "A material separation where blood is taken from an organism."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:CL_0002453 a rdfs:Class ;
  rdfs:label "oligodendrocyte precursor cell" ;
  rdfs:comment "The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." ;
  rdfs:subClassOf obo:CL_0000128 .

obo:CL_0000986 a rdfs:Class ;
  rdfs:label "IgM plasma cell" ;
  rdfs:subClassOf obo:CL_0000974 .

obo:CL_0002027 a rdfs:Class ;
  rdfs:label "CD9-positive, CD41-positive megakaryocyte cell" ;
  rdfs:subClassOf obo:CL_0000556 .

<http://www.ebi.ac.uk/efo/EFO_0005024> a rdfs:Class ;
  rdfs:label "placental pericyte"@en ;
  rdfs:comment "A pericyte derived from the placenta." ;
  rdfs:subClassOf obo:CL_0000669 .

obo:OBI_0600018 a rdfs:Class ;
  rdfs:label "material portioning"@en ;
  rdfs:comment "a material processing in which the input substance is partitioned into a number of portions that are similar in composition."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:CL_0000540 a rdfs:Class ;
  rdfs:label "neuron" ;
  rdfs:comment "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:SO_0000148 a rdfs:Class ;
  rdfs:label "supercontig" ;
  rdfs:comment "One or more contigs that have been ordered and oriented using end-read information. Contains gaps that are filled with N's." ;
  rdfs:subClassOf obo:SO_0000353 .

obo:OBI_0000953 a rdfs:Class ;
  rdfs:label "processed specimen" ;
  rdfs:comment "A specimen that has been intentionally physically modified." ;
  rdfs:subClassOf obo:OBI_0000047 , obo:OBI_0100051 .

obo:OBI_0001160 a rdfs:Class ;
  rdfs:label "assay validation objective"@en ;
  rdfs:comment "an objective specification to check the accuracy or the quality of the results of an assay by comparison with independent results"@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBIB_0000561 a rdfs:Class ;
  rdfs:label "clinical history of meningitis at death" ;
  rdfs:comment "A  clinical history in which there was active meningitis at death." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002579 a rdfs:Class ;
  rdfs:label "adapter-trimmed sequence data" ;
  rdfs:comment "The results of a data transformation of sequence data in which reference subsequences corresponding to ligated library adapters are removed." ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0400043 a rdfs:Class ;
  rdfs:label "flow cell"@en ;
  rdfs:comment "Aparatus in the fluidic subsystem where the sheath and sample meet. Can be one of several types; jet-in-air, quartz cuvette, or a hybrid of the two. The sample flows through the center of a fluid column of sheath fluid in the flow cell."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:OBI_0000448 a rdfs:Class ;
  rdfs:label "packed column"@en ;
  rdfs:comment "A packed column is a chromatography column where the particles of the solid stationary phase or the support coated with a liquid stationary phase may fill the whole inside volume of the tube."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CL_0002012 a rdfs:Class ;
  rdfs:label "Kit-low proerythroblast" ;
  rdfs:subClassOf obo:CL_0000547 .

obo:CARO_0000007 a rdfs:Class ;
  rdfs:label "immaterial anatomical entity" ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:NGBO_6000402 a rdfs:Class ;
  rdfs:label "name of data generation assay executor"@en ;
  rdfs:comment "A personal name that designates the person who executed the sequencing run." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBIB_0000274 a rdfs:Class ;
  rdfs:label "name of person responsible for specimen transport" ;
  rdfs:comment "A personal name that designates the person who is responsible for the transport of a specimen to another organization." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0000219 a rdfs:Class ;
  rdfs:label "cellular feature identification objective"@en ;
  rdfs:comment "Cellular_feature_identification_objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the cellular level, e.g. stage of cell cycle, stage of differentiation."@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0002525 a rdfs:Class ;
  rdfs:label "tibial artery specimen" ;
  rdfs:comment "A specimen that is derived from tibial artery." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0002246 a rdfs:Class ;
  rdfs:label "peripheral blood stem cell" ;
  rdfs:subClassOf obo:CL_0000037 .

obo:CL_0002479 a rdfs:Class ;
  rdfs:label "F4/80-positive adipose macrophage" ;
  rdfs:subClassOf obo:CL_0002477 .

obo:OBIB_0000474 a rdfs:Class ;
  rdfs:label "identification number of a protocol at a particular site" ;
  rdfs:comment "An centrally registered identifier symbol assigned by an Institutional Review Board (IRB) that identifies a particular protocol at a given site." ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:NGBO_0000065 a rdfs:Class ;
  rdfs:label "ACMG moderate classification criteria"@en ;
  rdfs:comment "ACMG guidelines for classification of variants of moderate classification" ;
  rdfs:subClassOf obo:NGBO_6000355 .

obo:CL_0002079 a rdfs:Class ;
  rdfs:label "pancreatic ductal cell" ;
  rdfs:comment "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0002966> .

obo:CL_0000646 a rdfs:Class ;
  rdfs:label "basal cell" ;
  rdfs:comment "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." ;
  rdfs:subClassOf obo:CL_0000034 .

obo:OBI_0100016 a rdfs:Class ;
  rdfs:label "blood plasma specimen"@en ;
  rdfs:comment "a material entity which corresponds to the liquid component of blood, in which the blood cells are suspended."@en ;
  rdfs:subClassOf obo:OBI_0000953 .

obo:CL_1000488 a rdfs:Class ;
  rdfs:label "cholangiocyte" ;
  rdfs:comment "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. [ PMID:18356246 PMID:16550043 GOC:tfm ] " ;
  rdfs:subClassOf obo:CL_0000066 .

<http://www.ebi.ac.uk/efo/EFO_0009501> a rdfs:Class ;
  rdfs:label "CWRU1" ;
  rdfs:comment "Induced pluripotent stem cells derived from MSC658 fibroblasts." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0004905> .

obo:CL_0002150 a rdfs:Class ;
  rdfs:label "epitheloid cell" ;
  rdfs:subClassOf obo:CL_0000766 .

obo:OBIB_0000510 a rdfs:Class ;
  rdfs:label "greater than moderate alcohol consumption history" ;
  rdfs:comment "An Alcohol Use History in which alcohol consumption was more than 2 drinks per day for men and more than 1 drink per day for women." ;
  rdfs:subClassOf obo:NCIT_C81229 .

obo:OBI_0000711 a rdfs:Class ;
  rdfs:label "library preparation" ;
  rdfs:comment "is a process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors." ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:OBI_0002025 a rdfs:Class ;
  rdfs:label "Human Exon 1.0 ST tilling array" ;
  rdfs:comment "A tiling microarray which is manufactured by the Affymetrix corporation. Built to analyze 3' DNA sequence copy number by comparative genomic hybridization for human DNA against 28,000 genes. It  can be used for gene expression and alternative splicing assay" ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:NGBO_6000279 a rdfs:Class ;
  rdfs:label "specimen acceptance or rejection protocol"@en ;
  rdfs:comment "A protocol which describe the criteria for acceptance or rejection of a specimen" ;
  rdfs:subClassOf obo:OBI_0000272 .

<http://www.ebi.ac.uk/efo/EFO_0002540> a rdfs:Class ;
  rdfs:label "nestin positive islet-derived progenitor cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000274 a rdfs:Class ;
  rdfs:label "hypertext transfer protocol secure"@en ;
  rdfs:comment "A data transfer protocol, and extension of the Hypertext Transfer Protocol (HTTP).  It is used for secure communication over a computer network, and is widely used on the Internet" ;
  rdfs:subClassOf obo:NGBO_6000273 .

<http://www.ebi.ac.uk/efo/EFO_0005289> a rdfs:Class ;
  rdfs:label "mural granulosa cell" ;
  rdfs:comment "The mural granulosa cells form during antral folliculogenesis, process in which a single antral cavity is formed, separating two functionally distinct granulosa cell populations. The mural granulosa cells line the wall of the follicle and are critical for steroidogenesis and ovulation." ;
  rdfs:subClassOf obo:CL_0000501 .

obo:IAO_0000064 a rdfs:Class ;
  rdfs:label "algorithm"@en ;
  rdfs:comment "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata."@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0002509 a rdfs:Class ;
  rdfs:label "sweat specimen" ;
  rdfs:comment "A specimen that is derived from sweat." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000057 a rdfs:Class ;
  rdfs:label "fibroblast" ;
  rdfs:comment "A large, flat, oval cell found in connective tissue and responsible for the formation of fibers." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000034 a rdfs:Class ;
  rdfs:label "adding specimen into a container"@en ;
  rdfs:comment "An adding a material entity into a target process where a collected specimen is added to a specimen container. (note, not used for other specimen process that produce new specimens)" ;
  rdfs:subClassOf obo:OBI_0000274 .

obo:OBIB_0000515 a rdfs:Class ;
  rdfs:label "current reformed smoker for less than 15 years history" ;
  rdfs:comment "A Smoking History in which there is no current smoking and has not been smoking for less than 15 years." ;
  rdfs:subClassOf obo:NCIT_C29719 .

obo:SO_0000104 a rdfs:Class ;
  rdfs:label "polypeptide" ;
  rdfs:comment "A sequence of amino acids linked by peptide bonds which may lack appreciable tertiary structure and may not be liable to irreversible denaturation." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:CL_0000775 a rdfs:Class ;
  rdfs:label "neutrophil" ;
  rdfs:comment "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." ;
  rdfs:subClassOf obo:CL_0000094 .

obo:OBIB_0000575 a rdfs:Class ;
  rdfs:label "clinical history of inability to have Human Immunodeficiency Virus testing due to hemodilution" ;
  rdfs:comment "A clinical history in which there is a history of the donor not being able to be tested for Human Immunodeficiency Virus (HIV) because of hemodilution." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_0000037 a rdfs:Class ;
  rdfs:label "SIFT score impact"@en ;
  rdfs:comment "Data item which represents a normalized probability of observing the new amino acid at that position and ranges from 0 to 1." ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0200174 a rdfs:Class ;
  rdfs:label "curve fitting objective"@en ;
  rdfs:comment "A curve fitting objective is a data transformation objective in which the aim is to find a curve which matches a series of data points and possibly other constraints."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:NGBO_6000105 a rdfs:Class ;
  rdfs:label "adapter ligation process"@en ;
  rdfs:comment "A material processing process which attaches synthetic oligonucleotides of a known sequence to one or both ends of cDNA fragments" ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:CL_0002334 a rdfs:Class ;
  rdfs:label "preadipocyte" ;
  rdfs:comment "An undifferentiated fibroblast that can be stimulated to form a fat cell." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000437 a rdfs:Class ;
  rdfs:label "analyte measurement objective"@en ;
  rdfs:comment "an assay objective to determine the presence or concentration of an analyte in the evaluant"@en ;
  rdfs:subClassOf obo:OBI_0000441 .

obo:OBIB_0000318 a rdfs:Class ;
  rdfs:label "name of specimen slide preparation technician" ;
  rdfs:comment "A personal name that designates the person who performed a specimen slide preparation." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001463 a rdfs:Class ;
  rdfs:label "transcription profiling by array assay" ;
  rdfs:comment "A transcription profiling assay that uses array technology." ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:CL_0002108 a rdfs:Class ;
  rdfs:label "CD38-negative IgG memory B cell" ;
  rdfs:subClassOf obo:CL_0000979 .

obo:OBI_0000192 a rdfs:Class ;
  rdfs:label "microtiter plate"@en ;
  rdfs:comment "A microtiter_plate is a flat plate with multiple wells used as small test tubes."@en ;
  rdfs:subClassOf obo:OBI_0000967 .

obo:CL_0000387 a rdfs:Class ;
  rdfs:label "hemocyte" ;
  rdfs:comment "A blood cell especially of an invertebrate animal." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002193 a rdfs:Class ;
  rdfs:label "myelocyte" ;
  rdfs:comment "A cell derived from a promyelocyte. It differentiates into a metamyelocyte. It has a diameter of 10-18 micrometer, and an oval or round nucleus with finely granulated chromatin." ;
  rdfs:subClassOf obo:CL_0002191 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000290 a rdfs:Class ;
  rdfs:label "specimen shipment identifier"@en ;
  rdfs:comment "An identifier which denotes number assigned by a shipper of specimen."@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000115> .

obo:CL_0000168 a rdfs:Class ;
  rdfs:label "beta cell" ;
  rdfs:comment "A cell that composes the bulk of the islets of Langerhans and secretes insulin." ;
  rdfs:subClassOf obo:UBERON_0000016 .

obo:CL_0000970 a rdfs:Class ;
  rdfs:label "unswitched memory B cell" ;
  rdfs:subClassOf obo:CL_0000787 .

obo:CL_0000679 a rdfs:Class ;
  rdfs:label "glutamatergic neuron" ;
  rdfs:subClassOf obo:CL_0000540 .

obo:OBI_0001885 a rdfs:Class ;
  rdfs:label "specimen repository organization"@en ;
  rdfs:comment "An organization that provides a service to store and distribute specimens" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:CL_0002318 a rdfs:Class ;
  rdfs:label "periperhal blood mesothelial cell" ;
  rdfs:subClassOf obo:CL_0000081 .

obo:CL_0002422 a rdfs:Class ;
  rdfs:label "enucleated reticulocyte" ;
  rdfs:subClassOf obo:CL_0000558 .

obo:CL_0002023 a rdfs:Class ;
  rdfs:label "CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell" ;
  rdfs:subClassOf obo:CL_0000553 .

obo:CL_0000769 a rdfs:Class ;
  rdfs:label "basophilic metamyelocyte" ;
  rdfs:subClassOf obo:CL_0000768 , obo:CL_0002192 .

obo:OBI_0002392 a rdfs:Class ;
  rdfs:label "exposure to second hand smoke in current household" ;
  rdfs:comment "An exposure to second hand smoke in person's current household." ;
  rdfs:subClassOf obo:OBI_0002390 .

obo:OBIB_0000060 a rdfs:Class ;
  rdfs:label "time in fixative measurement" ;
  rdfs:comment "A time measurement datum that states the duration during which a specimen was submerged in fixative." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0000836 a rdfs:Class ;
  rdfs:label "promyelocyte" ;
  rdfs:subClassOf obo:CL_0002191 .

obo:OBI_0002381 a rdfs:Class ;
  rdfs:label "grandmother clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a female parent of a parent." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0002575 a rdfs:Class ;
  rdfs:label "isoform sequencing" ;
  rdfs:comment "A method for sequencing isoforms by enriching a cDNA library for full-length reads spanning entire transcript isoforms." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:CL_0000232 a rdfs:Class ;
  rdfs:label "erythrocyte" ;
  rdfs:comment "A red blood cell. In mammals, mature erythrocytes are non-nucleated, biconcave disks containing hemoglobin whose function is to transport oxygen." ;
  rdfs:subClassOf obo:CL_0000764 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000252 a rdfs:Class ;
  rdfs:label "blood plasma specimen barcode" ;
  rdfs:comment "A specimen barcode that is associated with a blood plasma specimen." ;
  rdfs:subClassOf obo:FLU_0001019 .

obo:NGBO_6000296 a rdfs:Class ;
  rdfs:label "refrigerated specimen temperature"@en ;
  rdfs:comment "A specimen shipping tempruture which represent a Refrigerated temperature (2 to 8°C) - wet ice or gel packs (conditioned at –15°C, designed for refrigerated temperatures, or phase change material rated for refrigerated transport)." ;
  rdfs:subClassOf obo:NGBO_6000294 , obo:PATO_0000146 .

obo:OBI_0400149 a rdfs:Class ;
  rdfs:label "protein microarray"@en ;
  rdfs:comment "A protein-microarray is a microarray, ususlly a piece of glass, on which different molecules of protein have been affixed at separate locations in an ordered manner. These are used to identify protein-protein or protein-small molecule interactions."@en ;
  rdfs:subClassOf obo:OBI_0400147 .

obo:OBI_0100026 a rdfs:Class ;
  rdfs:label "organism"@en ;
  rdfs:comment "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:BTO_0004298 a rdfs:Class ;
  rdfs:label "corneal epithelial cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002503 a rdfs:Class ;
  rdfs:label "feces specimen" ;
  rdfs:comment "A specimen that is derived from feces." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000441 a rdfs:Class ;
  rdfs:label "assay objective"@en ;
  rdfs:comment "an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role)"@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:CL_0000051 a rdfs:Class ;
  rdfs:label "common lymphoid progenitor" ;
  rdfs:subClassOf obo:CL_0002032 .

obo:OBI_0001867 a rdfs:Class ;
  rdfs:label "establishing cell line" ;
  rdfs:comment "a process whereby a new type of cell line is created, either through passaging of a primary cell culture to relative genetic stability and compositional homogeneity, or through some experimental modification of an existing cell line to produce a new line with novel characteristics  (e.g. immortalization or some other stable genetic modification, or selection of some defined subset)." ;
  rdfs:subClassOf obo:OBI_0600036 .

obo:OBI_0001964 a rdfs:Class ;
  rdfs:label "decision-theoretic analysis objective" ;
  rdfs:comment "An objective specification which what includes a description of two or more alternative actions to take in a particular situation and a metric that enables comparisons of the two actions. The objective specified is achieved in a planned process which includes a data transformation, the output of which is an identification of the 'best' choice according to the metric." ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:CL_0000582 a rdfs:Class ;
  rdfs:label "neutrophilic metamyelocyte" ;
  rdfs:subClassOf obo:CL_0000776 , obo:CL_0002192 .

obo:OMIABIS_0000047 a rdfs:Class ;
  rdfs:label "biobank identifier with ISO 3166-1 alpha-2 code and CTEP organization identifier"@en ;
  rdfs:comment "A biobank identifier that has both an ISO 3166-1 alpha-2 code and a CTEP organization code."@en ;
  rdfs:subClassOf obo:OMIABIS_0000005 .

obo:CL_0000941 a rdfs:Class ;
  rdfs:label "thymic conventional dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:OBI_0000703 a rdfs:Class ;
  rdfs:label "Illumina Genome Analyzer II" ;
  rdfs:comment "is a DNA sequence which is manufactured by Illumina (Solexa) corporation. it support sequencing of single or paired end clone libraries relying on sequencing by synthesis technology" ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:NGBO_0000055 a rdfs:Class ;
  rdfs:label "PS1 criteria"@en ;
  rdfs:comment """Same amino acid change as a previously established pathogenic variant
regardless of nucleotide change""" ;
  rdfs:subClassOf obo:NGBO_0000063 .

obo:OBI_0000242 a rdfs:Class ;
  rdfs:label "software testing objective"@en ;
  rdfs:comment "Software_testing_objective is a hardware_optimization role describing a study designed to examine the effects of using different software or software parameters, e.g. data processing software."@en ;
  rdfs:subClassOf obo:OBI_0000208 .

obo:OBI_0001851 a rdfs:Class ;
  rdfs:label "transcription start site identification objective"@en ;
  rdfs:comment "A transcription profiling identification objective that aims to characterize the transcription start sites of genes." ;
  rdfs:subClassOf obo:OBI_0001331 .

obo:CL_0000049 a rdfs:Class ;
  rdfs:label "common myeloid progenitor" ;
  rdfs:subClassOf obo:CL_0002032 .

obo:CL_0002110 a rdfs:Class ;
  rdfs:label "B220-low CD38-positive naive B cell" ;
  rdfs:subClassOf obo:CL_0002101 .

obo:NGBO_6000413 a rdfs:Class ;
  rdfs:label "bioinformatics software parameter name"@en ;
  rdfs:comment "Information about software includes information on software parameter name." ;
  rdfs:subClassOf obo:NGBO_6000409 .

obo:NGBO_6000007 a rdfs:Class ;
  rdfs:label "FASTQ format"@en ;
  rdfs:comment "A file format which represent text-based format for storing both a biological sequence (usually nucleotide sequence) and its corresponding quality scores" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:OBIB_0000565 a rdfs:Class ;
  rdfs:label "clinical history of unexplained seizures" ;
  rdfs:comment "A clinical history in which there is a history of unexplained seizures." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000398 a rdfs:Class ;
  rdfs:label "polygonal cell"@en ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000274 a rdfs:Class ;
  rdfs:label "adding a material entity into a target"@en ;
  rdfs:comment "is a process with the objective to place a material entity bearing the 'material to be added role' into a material bearing the 'target of material addition role'."@en ;
  rdfs:subClassOf obo:OBI_0000652 .

obo:OBIB_0000263 a rdfs:Class ;
  rdfs:label "cell pellet specimen barcode" ;
  rdfs:comment "A specimen barcode that is associated with a cell pellet specimen." ;
  rdfs:subClassOf obo:FLU_0001019 .

obo:NGBO_6000124 a rdfs:Class ;
  rdfs:label "variant calling assay"@en ;
  rdfs:comment "Variant calling is the process by which we identify variants from sequence data." ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:OGMS_0000031 a rdfs:Class ;
  rdfs:label "disease" ;
  rdfs:comment "A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."@en ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBI_0000465 a rdfs:Class ;
  rdfs:label "organic acid column"@en ;
  rdfs:comment "An organic acid column is a chromatography column which enables (reversed-phase) separation of hydrophilic aliphatic and aromatic organic acids with UV detection. Organic acid columns allow retention of polar and apolar organic acids and are hydrolysis resistant."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CL_0000185 a rdfs:Class ;
  rdfs:label "myoepithelial cell" ;
  rdfs:comment "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament. [ GOC:tfm ISBN:0721662544 ] " ;
  rdfs:subClassOf obo:CL_0000066 .

obo:CL_0002060 a rdfs:Class ;
  rdfs:label "melanophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:GENEPIO_0001795 a rdfs:Class ;
  rdfs:label "de-identified data"@en ;
  rdfs:comment "A 'de-identified data' role between a user and given data entails that the user is authorized to see only those fields (including those that are encrypted) which do not contain information that could be use to identify particular individuals (whether patients or medical practitioners) or potentially organizations in the case where an investigation may implicate them."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0000671 a rdfs:Class ;
  rdfs:label "sample from organism" ;
  rdfs:comment "a material obtained from an organism in order to be a representative of the whole" ;
  rdfs:subClassOf obo:OBI_0000747 , obo:OBI_0001479 .

obo:CL_0000872 a rdfs:Class ;
  rdfs:label "splenic marginal zone macrophage" ;
  rdfs:subClassOf obo:CL_0000871 .

obo:OBI_0002375 a rdfs:Class ;
  rdfs:label "daughter clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a person's female child." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_1110087 a rdfs:Class ;
  rdfs:label "donor"@en ;
  rdfs:comment "A role which inheres in an organism or part thereof from which any part including cell, organ or tissue is removed with the intention that the donated part will be placed into another organism and/or cultured in vitro."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

<http://www.ebi.ac.uk/efo/EFO_0002666> a rdfs:Class ;
  rdfs:label "monocyte-derived osteoclast" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0200180 a rdfs:Class ;
  rdfs:label "spread calculation objective"@en ;
  rdfs:comment "is a data transformation objective whereby the aim is to the calculate the spread of a dataset, spread is a descriptive statistic which describes the variability of values in a data set " ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0002395 a rdfs:Class ;
  rdfs:label "Gr1-high classical monocyte" ;
  rdfs:subClassOf obo:CL_0000860 .

<http://www.ebi.ac.uk/efo/EFO_0003970> a rdfs:Class ;
  rdfs:label "mouse erythroleukemia cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:BTO_0000238 a rdfs:Class ;
  rdfs:label "cerebrovascular endothelial cell" ;
  rdfs:comment """
Endothelial cell of or involving the cerebrum and the blood vessels supplying it.
""" ;
  rdfs:subClassOf obo:CL_0000115 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000526 a rdfs:Class ;
  rdfs:label "duration of hormonal birth control use prior to enrollment" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration of use of hormonally based birth control prior to enrollment in a study." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:BFO_0000019 a rdfs:Class ;
  rdfs:label "quality"@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:NGBO_6000029 a rdfs:Class ;
  rdfs:label "shipping and receiving of samples SOP"@en ;
  rdfs:comment "A standard operating procedure for shipping and receiving of sample" ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:OBI_0002571 a rdfs:Class ;
  rdfs:label "polyA-selected RNA sequencing assay" ;
  rdfs:comment "An RNA-seq assay to study transcriptomes through the enrichment of polyadenylated transcripts or removal of ribosomal RNA prior to high-throughput sequencing." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBIB_0000550 a rdfs:Class ;
  rdfs:label "clinical history of ascites" ;
  rdfs:comment "A clinical history in which there is a history of the presence of ascites fluid." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:PATO_0000383 a rdfs:Class ;
  rdfs:label "female" ;
  rdfs:comment "A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes." ;
  rdfs:subClassOf obo:PATO_0000047 , obo:PATO_0001894 .

obo:CL_0000562 a rdfs:Class ;
  rdfs:label "nucleate erythrocyte" ;
  rdfs:subClassOf obo:CL_0000232 .

obo:OBI_0002550 a rdfs:Class ;
  rdfs:label "sigmoid colon specimen" ;
  rdfs:comment "A specimen that is derived from sigmoid colon." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000963 a rdfs:Class ;
  rdfs:label "Bm3-delta B cell" ;
  rdfs:subClassOf obo:CL_0000844 .

obo:OBIB_0000586 a rdfs:Class ;
  rdfs:label "clinical history of exposure to Severe Acute Respiratory Syndrome" ;
  rdfs:comment "A clinical history in which there is a history of recent contact with someone who has Severe Acute Respiratory Syndrome (SARS)." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBIB_0000298 a rdfs:Class ;
  rdfs:label "adherence of stage and replicate numbers to FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether the number of stages and replicates followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:CL_0000860 a rdfs:Class ;
  rdfs:label "classical monocyte" ;
  rdfs:subClassOf obo:CL_0000576 .

obo:OBI_0001361 a rdfs:Class ;
  rdfs:label "transcription profiling by RT-PCR assay" ;
  rdfs:comment "A transcription profiling assay that uses reverse transcription PCR (RT-PCR)." ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_0000096 a rdfs:Class ;
  rdfs:label "protocol testing objective"@en ;
  rdfs:comment "Protocol_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different protocols."@en ;
  rdfs:subClassOf obo:OBI_0000208 .

obo:OBI_0002546 a rdfs:Class ;
  rdfs:label "liver specimen" ;
  rdfs:comment "A specimen that is derived from liver." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000613 a rdfs:Class ;
  rdfs:label "basophil progenitor cell" ;
  rdfs:subClassOf obo:CL_0002191 .

obo:OBI_0200111 a rdfs:Class ;
  rdfs:label "data visualization"@en ;
  rdfs:comment "An planned process that creates images, diagrams or animations from the input data."@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0001619 a rdfs:Class ;
  rdfs:label "specimen collection time measurement datum"@en ;
  rdfs:comment "A time measurement datum that is the measure of the time when the specimens are collected."@en ;
  rdfs:subClassOf obo:IAO_0000416 .

<http://www.ebi.ac.uk/efo/EFO_0005934> a rdfs:Class ;
  rdfs:label "disease cell type"@en ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0001127 a rdfs:Class ;
  rdfs:label "freeze substitution system" ;
  rdfs:comment "A device or system for dehydrating and then chemically fixing electron microscopy samples at low temperatures in preparation for various treatments including embedding in resins." ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:OBIB_0000041 a rdfs:Class ;
  rdfs:label "duration time of smoking regularly"@en ;
  rdfs:comment "A duration time of smoking about how long a person has been smoking regularly. (better to have criteria of regularly mean, such as smoke everyday)" ;
  rdfs:subClassOf obo:OBIB_0000053 .

obo:OBI_0200083 a rdfs:Class ;
  rdfs:label "survival analysis objective"@en ;
  rdfs:comment "A data transformation objective which has the data transformation aims to model time to event data (where events are e.g. death and or disease recurrence); the purpose of survival analysis is to model the underlying distribution of event times and to assess the dependence of the event time on other explanatory variables" ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0000038 a rdfs:Class ;
  rdfs:label "erythroid progenitor cell" ;
  rdfs:comment "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." ;
  rdfs:subClassOf obo:CL_0000764 , obo:CL_0000839 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:PATO_0000011 a rdfs:Class ;
  rdfs:label "age" ;
  rdfs:comment "A time quality inhering in a bearer by virtue of how long the bearer has existed." ;
  rdfs:subClassOf obo:PATO_0001018 , obo:PATO_0001237 .

obo:CL_0000990 a rdfs:Class ;
  rdfs:label "conventional dendritic cell" ;
  rdfs:subClassOf obo:CL_0000451 .

obo:OBIB_0000314 a rdfs:Class ;
  rdfs:label "FFPE tissue block handling, tracking, and storage SOP" ;
  rdfs:comment "A standard operating procedure for the handling, tracking, and storing of a formalin-fixed paraffin-embedded (FFPE) tissue block." ;
  rdfs:subClassOf obo:OBIB_0000070 .

<http://www.ebi.ac.uk/efo/EFO_0000324> a rdfs:Class ;
  rdfs:label "cell type" ;
  rdfs:comment "A cell type is a distinct morphological or functional form of cell.  Examples are epithelial, glial etc." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000434 a rdfs:Class ;
  rdfs:label "adding material objective"@en ;
  rdfs:comment "is the specification of an objective to add a material into a target material. The adding is asymmetric in the sense that the target material largely retains its identity"@en ;
  rdfs:subClassOf obo:OBI_0000686 .

obo:OBI_0000996 a rdfs:Class ;
  rdfs:label "device creation objective" ;
  rdfs:comment "an objective which aims to create a device with a specified function" ;
  rdfs:subClassOf obo:OBI_0000456 .

<http://www.ebi.ac.uk/efo/EFO_0000572> a rdfs:Class ;
  rdfs:label "lymphoblast" ;
  rdfs:comment "An immature lymphocyte that has enlarged in response to antigenic stimulation." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000387 a rdfs:Class ;
  rdfs:label "name of submitter of pathology case summary report." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0002015 a rdfs:Class ;
  rdfs:label "transcription profiling by MPSS assay" ;
  rdfs:comment "A transcription profiling assay that uses Massive Parallel Signature Sequencing (MPSS)." ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:OBI_0002467 a rdfs:Class ;
  rdfs:label "alignment counting application"@en ;
  rdfs:comment "A software application that implements an alignment counting algorithm, used to count the overlap of aligned sequencing reads with genes."@en ;
  rdfs:subClassOf obo:IAO_0000594 .

obo:OBIB_0000554 a rdfs:Class ;
  rdfs:label "clinical history of animal tissue xenotransplant" ;
  rdfs:comment "A clinical  history in which there is a history of receiving an animal tissue or organ xenotransplant." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0002105 a rdfs:Class ;
  rdfs:label "CD38-positive IgG memory B cell" ;
  rdfs:subClassOf obo:CL_0000979 .

obo:CL_0000861 a rdfs:Class ;
  rdfs:label "elicited macrophage" ;
  rdfs:subClassOf obo:CL_0000235 .

obo:CL_0000974 a rdfs:Class ;
  rdfs:label "long lived plasma cell" ;
  rdfs:subClassOf obo:CL_0000786 .

obo:CL_0001000 a rdfs:Class ;
  rdfs:label "CD8_alpha-positive CD11b-negative dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:NGBO_6000200 a rdfs:Class ;
  rdfs:label "metagenomics sequence data"@en ;
  rdfs:comment "DNA sequence data which represent genomic DNA obtained from environmental samples"@en ;
  rdfs:subClassOf obo:OBI_0001573 .

obo:CL_0000520 a rdfs:Class ;
  rdfs:label "prokaryotic cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002144 a rdfs:Class ;
  rdfs:label "extrachromosomal circular DNA sequencing assay" ;
  rdfs:comment "An assay which aims at identifying the endogenous population of extrachromosomal circular DNA originating from a subset of genomic loci and potentially having profound consequences on the regulatory and coding capabilities of these regions. The assay includes creation of a library out of the circular DNA molecules and subsequent sequencing using parallelized sequencing methods." ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBIB_0000590 a rdfs:Class ;
  rdfs:label "clinical history of syphilis" ;
  rdfs:comment "A clinical history in which there is a history of active syphilis infection or treatment for syphilis in the recent past." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002521 a rdfs:Class ;
  rdfs:label "renal medulla specimen" ;
  rdfs:comment "A specimen that is derived from renal medulla." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0002112 a rdfs:Class ;
  rdfs:label "B220-positive CD38-negative unswitched memory B cell" ;
  rdfs:subClassOf obo:CL_0002111 .

obo:PO_0006204 a rdfs:Class ;
  rdfs:label "sporocyte" ;
  rdfs:comment "A native plant cell (PO:0025606) which is diploid (2n), and undergoes meiosis (GO:0007126) to produce four haploid (1n) plant spores (PO:0025017)." ;
  rdfs:subClassOf obo:PO_0025606 .

obo:OBI_0000810 a rdfs:Class ;
  rdfs:label "informed consent process" ;
  rdfs:comment "A planned process in which a person or their legal representative is informed about key facts about potential risks and benefits of a process and makes a documented decision as to whether the person in question will participate." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:CL_0002001 a rdfs:Class ;
  rdfs:label "CD34-positive, CD38-positive granulocyte monocyte progenitor" ;
  rdfs:subClassOf obo:CL_0000557 .

obo:GENO_0000815 a rdfs:Class ;
  rdfs:label "sequence feature location"@en ;
  rdfs:comment "The location of a sequence feature as defined by its start and end position on some reference coordinate system." ;
  rdfs:subClassOf obo:BFO_0000031 .

obo:BFO_0000035 a rdfs:Class ;
  rdfs:label "process boundary"@en ;
  rdfs:comment "p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])"@en ;
  rdfs:subClassOf obo:BFO_0000003 .

obo:NGBO_0000062 a rdfs:Class ;
  rdfs:label "PM4 criteria"@en ;
  rdfs:comment "Protein length changes due to in-frame deletions/insertions in a non-repeat region or stop-loss variants" ;
  rdfs:subClassOf obo:NGBO_0000065 .

obo:CL_0002472 a rdfs:Class ;
  rdfs:label "MHC-II-low non-classical monocyte" ;
  rdfs:subClassOf obo:CL_0002058 .

obo:NCBITaxon_32523 a rdfs:Class ;
  rdfs:label "Tetrapoda" ;
  rdfs:subClassOf obo:NCBITaxon_117571 .

obo:OBIB_0000576 a rdfs:Class ;
  rdfs:label "clinical history of unexplained weight loss" ;
  rdfs:comment "A clinical history in which there is a history of unexplained weight loss." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000949 a rdfs:Class ;
  rdfs:label "IgD plasmablast" ;
  rdfs:subClassOf obo:CL_0000980 .

obo:OBI_0302903 a rdfs:Class ;
  rdfs:label "nucleic acid hybridization"@en ;
  rdfs:comment "a planned process by which totally or partially complementary, single-stranded nucleic acids are  combined into a single molecule called heteroduplex or homoduplex to an extent depending on the amount of complementarity."@en ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:OBI_0002374 a rdfs:Class ;
  rdfs:label "brother clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male sibling." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBIB_0000287 a rdfs:Class ;
  rdfs:label "name of team leader for filling out tissue recovery form" ;
  rdfs:comment "A personal name that designates the person who is the leader of the team responsible for entering the tissue recovery form data." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0002005 a rdfs:Class ;
  rdfs:label "Methylation 27K BeadChip" ;
  rdfs:comment "A methylation BeadChip which is manufactured by the Illumina corporation. Built upon BeadChip tehcnology, the array interrogates ~ 27,000 CpG sites per sample at single-nucleotide resolution." ;
  rdfs:subClassOf obo:OBI_0001870 .

obo:GENEPIO_0001800 a rdfs:Class ;
  rdfs:label "sequence identifier"@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:NGBO_6000089 a rdfs:Class ;
  rdfs:label "name of specimen donor"@en ;
  rdfs:comment "A personal name that designates the human being donated specimen" ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001928 a rdfs:Class ;
  rdfs:label "selection"@en ;
  rdfs:comment "A planned process which results in the creation of group of entity from a larger group by the application of predefined criteria."@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:OBI_0002520 a rdfs:Class ;
  rdfs:label "heart specimen" ;
  rdfs:comment "A specimen that is derived from heart." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:REO_0000171 a rdfs:Class ;
  rdfs:label "molecular label role"@en ;
  rdfs:comment "a reagent role inhering in a molecular entity intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay." ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002445 a rdfs:Class ;
  rdfs:label "transcription start site mapping by primer extension assay" ;
  rdfs:comment "A transcription profiling assay in which the transcription start site for a gene is determined by identifying the 5' end of mRNA. A radio-labeled primer is annealed to a complementary mRNA sequence near the 3' end, then cDNA is synthesized until the 5' end is reached." ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:NGBO_6000385 a rdfs:Class ;
  rdfs:label "data storage datum"@en ;
  rdfs:comment "A data item that represent information on data storage."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:PATO_0000140 a rdfs:Class ;
  rdfs:label "position" ;
  rdfs:comment "A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity." ;
  rdfs:subClassOf obo:PATO_0001018 .

obo:OMIABIS_0000003 a rdfs:Class ;
  rdfs:label "biobank proper name"@en ;
  rdfs:comment "An identifier in natural language referring  to a biobank."@en ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:OBI_0000844 a rdfs:Class ;
  rdfs:label "hospital" ;
  rdfs:comment "A medical organization at which sick or injured people are given clinical care" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:CL_0000989 a rdfs:Class ;
  rdfs:label "CD11c-low plasmacytoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000784 .

obo:OBI_0000496 a rdfs:Class ;
  rdfs:label "capillary column"@en ;
  rdfs:comment "A capillary column is a thin tube with a small inner diameter, usually around 0.5 mm."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:NGBO_6000217 a rdfs:Class ;
  rdfs:label "local sequence alignment"@en ;
  rdfs:comment "A sequence alignment which align dissimilar sequences that are suspected to contain regions of similarity or similar sequence motifs within their larger sequence context" ;
  rdfs:subClassOf obo:OBI_0002567 .

obo:OBI_0000379 a rdfs:Class ;
  rdfs:label "mechanical function"@en ;
  rdfs:comment "A mechanical function is a function that is realised via mechanical work (through an certain amount of energy transferred by some force)."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBIB_0000380 a rdfs:Class ;
  rdfs:label "name of dissector of normal adjacent tissue to tumor for FFPE" ;
  rdfs:comment "A personal name that designates the person who performed the dissection of a normal tissue adjacent to a tumor for a formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001917 a rdfs:Class ;
  rdfs:label "chromosome conformation identification objective"@en ;
  rdfs:comment "A molecular feature identification objective that aims to determine spatial organization of chromatin." ;
  rdfs:subClassOf obo:OBI_0000131 .

obo:CL_0000964 a rdfs:Class ;
  rdfs:label "Bm2' B cell" ;
  rdfs:subClassOf obo:CL_0000844 .

obo:NGBO_6000689 a rdfs:Class ;
  rdfs:label "user information"@en ;
  rdfs:comment "An information content entity about user authentication information." ;
  rdfs:subClassOf obo:IAO_0000030 .

<http://www.ebi.ac.uk/efo/EFO_0002968> a rdfs:Class ;
  rdfs:label "embryonic stem cell derived neuronal stem cell" ;
  rdfs:comment "neural stem cells experimentally derived from ES cells" ;
  rdfs:subClassOf obo:CL_0000034 .

obo:OBI_0000686 a rdfs:Class ;
  rdfs:label "material combination objective" ;
  rdfs:comment "is an objective to obtain an output material that contains several input materials." ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:NGBO_6000092 a rdfs:Class ;
  rdfs:label "material transfer agreement"@en ;
  rdfs:comment "A document which represent a contract that governs the transfer of tangible research materials between two organizations, when the recipient intends to use it for his or her own research purposes." ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0000151 a rdfs:Class ;
  rdfs:label "filter paper"@en ;
  rdfs:comment "a device manufacture with the intent to provide a porous unsized paper used for filtering."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

<http://edamontology.org/data_1093> a rdfs:Class ;
  rdfs:label "Sequence accession" ;
  rdfs:comment "A persistent, unique identifier of a molecular sequence database entry."@en ;
  rdfs:subClassOf obo:GENEPIO_0001800 .

obo:OBI_0000485 a rdfs:Class ;
  rdfs:label "chromatography instrument"@en ;
  rdfs:comment "Any instrument that is used to carry out a chromatography experiment."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:OBI_0000689 a rdfs:Class ;
  rdfs:label "454 Genome Sequence 20" ;
  rdfs:comment """is a DNA sequencer which is manufactured by 454 Life Science Corporation and enables pyrosequencing to be performed. It comprises both optics and fluidics subsystems, which are
controlled by a computer subsystem. The fluidics subsystem ensures accurate reagent dispensing. It consists of a reagents cassette (which holds the reagent containers), a sipper manifold, pumps, valves, and debubblers. The fluidics subsystem flows the sequencing reagents across the wells of the PicoTiterPlate device, and moves the spent reagents from the PicoTiterPlate device to the waste receptacle. The optics subsystem consists of a CCD camera and a camera controller. The camera captures the light emitted in the wells of the PicoTiterPlate device during each step of the sequencing cycle, and sends the digital images to the computer subsystem for processing. The computer controls the other Sequencer subsystems, and processes the digital images sent by the camera to extract the DNA sequence information.""" ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0002010 a rdfs:Class ;
  rdfs:label "Human 3x720K Whole Genome CGH Tiling Array" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 3x720,000 features." ;
  rdfs:subClassOf obo:OBI_0001307 .

<http://www.ebi.ac.uk/efo/EFO_1001468> a rdfs:Class ;
  rdfs:label "mantle cell"@en ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000549 a rdfs:Class ;
  rdfs:label "basophilic erythroblast" ;
  rdfs:comment "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." ;
  rdfs:subClassOf obo:CL_0000765 .

obo:OBI_0001625 a rdfs:Class ;
  rdfs:label "sequence annotation algorithm"@en ;
  rdfs:comment "An algorithm used to identify sequence features (e.g. protein coding regions) in the assembled contig sequence.  This may also include a description of any manual curation that may have generated or validated the annotation."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0002768 a rdfs:Class ;
  rdfs:label "whole virome sequencing assay" ;
  rdfs:comment "A whole metagenome sequencing assay that intends to provide information on multiple genome sequences from different viruses present in the same input sample." ;
  rdfs:subClassOf obo:OBI_0002623 .

obo:CL_0000628 a rdfs:Class ;
  rdfs:label "photosynthetic cell" ;
  rdfs:comment """
A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source.
""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000018 a rdfs:Class ;
  rdfs:label "material supplier role"@en ;
  rdfs:comment "a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation."@en ;
  rdfs:subClassOf obo:OBI_0000947 .

obo:CL_0000034 a rdfs:Class ;
  rdfs:label "stem cell" ;
  rdfs:comment "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002598 a rdfs:Class ;
  rdfs:label "bronchial smooth muscle cell" ;
  rdfs:subClassOf obo:CL_0000192 .

obo:BFO_0000020 a rdfs:Class ;
  rdfs:label "specifically dependent continuant"@en ;
  rdfs:comment "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:OBI_0000055 a rdfs:Class ;
  rdfs:label "software optimization objective"@en ;
  rdfs:comment "Software_optimization is a software_testing_objective role describing a study designed to identify the best software or parameters of the software."@en ;
  rdfs:subClassOf obo:OBI_0000242 .

obo:CL_0002101 a rdfs:Class ;
  rdfs:label "CD38-positive naive B cell" ;
  rdfs:subClassOf obo:CL_0000788 .

obo:OBI_0001307 a rdfs:Class ;
  rdfs:label "tiling microarray"@en ;
  rdfs:comment "a DNA microarray which has short fragments of nucleic acid immobilized on a substrate. These are designed to cover the whole genome of the target species. Tiling arrays are used to determine genome binding in ChIP assays or to identify transcribed regions." ;
  rdfs:subClassOf obo:OBI_0400148 .

obo:NGBO_0000066 a rdfs:Class ;
  rdfs:label "ACMG very strong classification criteria"@en ;
  rdfs:comment "ACMG guidelines for classification of variants of very strong classification" ;
  rdfs:subClassOf obo:NGBO_6000355 .

obo:OBI_0001137 a rdfs:Class ;
  rdfs:label "protein sequencer" ;
  rdfs:comment "An device that is used to determine the order of amino acids in protein sequences." ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:NGBO_6000057 a rdfs:Class ;
  rdfs:label "reference genome version number"@en ;
  rdfs:comment "A reference genome datum which represent reference genome edition" ;
  rdfs:subClassOf obo:IAO_0000129 , obo:NGBO_6000244 .

obo:CL_0000786 a rdfs:Class ;
  rdfs:label "plasma cell" ;
  rdfs:comment "A terminally differentiated cell of the B lymphocyte lineage that produces antibodies; plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern." ;
  rdfs:subClassOf obo:CL_0000151 .

obo:NGBO_6000255 a rdfs:Class ;
  rdfs:label "library construction kit"@en ;
  rdfs:comment "An assay kit processed material that include a set of articles or equipment needed for library construction"@en ;
  rdfs:subClassOf obo:NGBO_6000236 .

obo:OBI_0001153 a rdfs:Class ;
  rdfs:label "genetic transformation objective"@en ;
  rdfs:comment "a material transformation objective aims to create genetically modified organism or cell"@en ;
  rdfs:subClassOf obo:OBI_0000456 .

obo:CL_0000942 a rdfs:Class ;
  rdfs:label "thymic plasmacytoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000784 .

obo:CL_0001001 a rdfs:Class ;
  rdfs:label "immature CD8_alpha-negative CD11b-negative dendritic cell" ;
  rdfs:subClassOf obo:CL_0000998 .

obo:OBI_0002466 a rdfs:Class ;
  rdfs:label "alignment counting algorithm" ;
  rdfs:comment "An algorithm used to assign aligned sequence reads, resulting from a reference genome transcriptome alignment algorithm, to sequence features (e.g. genes or transcripts)."@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:CL_0002461 a rdfs:Class ;
  rdfs:label "CD103-positive dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:CL_0000983 a rdfs:Class ;
  rdfs:label "IgM plasmablast" ;
  rdfs:subClassOf obo:CL_0000980 .

obo:CL_0002031 a rdfs:Class ;
  rdfs:label "hematopoietic lineage restricted progenitor cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000475 a rdfs:Class ;
  rdfs:label "probe ID"@en ;
  rdfs:comment "An Identifier of an oligonucleotide probe." ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000115> .

obo:OBIB_0000587 a rdfs:Class ;
  rdfs:label "clinical history of West Nile Virus" ;
  rdfs:comment "A clinical history in which there is a history of West Nile Virus (WNV) infection." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0001969 a rdfs:Class ;
  rdfs:label "biodiversity assessment objective"@en ;
  rdfs:comment "biodiversity assessment objective is an objective of a planned process aimed at producing data item whose interpretation should provide insight about variety of biological species found in a biological sample at macroscopic or microscopic level"@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:NGBO_6000405 a rdfs:Class ;
  rdfs:label "assay kit version"@en ;
  rdfs:comment "A version number of assay kit." ;
  rdfs:subClassOf obo:IAO_0000129 .

obo:IAO_0000591 a rdfs:Class ;
  rdfs:label "software method"@en ;
  rdfs:comment "A software method (also called subroutine, subprogram, procedure, method, function, or routine) is software designed to execute a specific task."@en ;
  rdfs:subClassOf obo:IAO_0000010 .

obo:CL_0000564 a rdfs:Class ;
  rdfs:label "neutrophilic promyelocyte" ;
  rdfs:subClassOf obo:CL_0000836 .

obo:NGBO_6000416 a rdfs:Class ;
  rdfs:label "software Documentation URI"@en ;
  rdfs:comment "Information about software includes software documentation URI" ;
  rdfs:subClassOf obo:NGBO_6000409 .

obo:OBI_0400148 a rdfs:Class ;
  rdfs:label "DNA microarray"@en ;
  rdfs:comment "A DNA-microarray is a microarray that is used as a physical 2D immobilisation matrix for DNA sequences. DNA microarray-bound DNA fragments are used as targets for a hybridising probed sample."@en ;
  rdfs:subClassOf obo:OBI_0400147 .

obo:CL_0000978 a rdfs:Class ;
  rdfs:label "IgM short lived plasma cell" ;
  rdfs:subClassOf obo:CL_0000975 .

obo:CL_0000617 a rdfs:Class ;
  rdfs:label "GABAergic neuron" ;
  rdfs:comment "A neuron that uses GABA as a vesicular neurotransmitter" ;
  rdfs:subClassOf obo:CL_0000540 .

obo:CL_0000994 a rdfs:Class ;
  rdfs:label "immature CD11c-negative plasmacytoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000991 .

obo:OBI_0000208 a rdfs:Class ;
  rdfs:label "methodology testing objective"@en ;
  rdfs:comment "Methodology_testing_objective is an objective role carried out by a proposition defining the aim of the study is to examine the effect of using different methodologies."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:CL_0001012 a rdfs:Class ;
  rdfs:label "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor" ;
  rdfs:subClassOf obo:CL_0002032 .

obo:OBI_0002109 a rdfs:Class ;
  rdfs:label "Human 6x630K CGH Whole Genome Tiling Array" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 6x630,000 features." ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:CL_0001004 a rdfs:Class ;
  rdfs:label "immature CD8_alpha-positive CD11b-negative dendritic cell" ;
  rdfs:subClassOf obo:CL_0001000 .

obo:CL_0000160 a rdfs:Class ;
  rdfs:label "goblet cell" ;
  rdfs:comment "A cell of the epithelial lining that produce and secrete mucins." ;
  rdfs:subClassOf obo:CL_0000066 , obo:CL_0000151 .

obo:OBIB_0000594 a rdfs:Class ;
  rdfs:label "clinical history of lupus" ;
  rdfs:comment "A clinical history in which there is a history of systemic lupus" ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000581 a rdfs:Class ;
  rdfs:label "peritoneal macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:OBIB_0000529 a rdfs:Class ;
  rdfs:label "duration of hormone replacement therapy prior to enrollment" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration of hormone replacement therapy prior to enrollment in a study." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBIB_0000598 a rdfs:Class ;
  rdfs:label "clinical history of rheumatoid arthritis" ;
  rdfs:comment "A clinical history in which there is a history of rheumatoid arthritis." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:PATO_0000047 a rdfs:Class ;
  rdfs:label "sex" ;
  rdfs:comment "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved." ;
  rdfs:subClassOf obo:BFO_0000019 , obo:PATO_0001995 .

obo:CL_0002553 a rdfs:Class ;
  rdfs:label "lung fibroblast"@en ;
  rdfs:comment "A fibroblast that is part of lung" ;
  rdfs:subClassOf obo:CL_0000057 .

obo:OBI_0002117 a rdfs:Class ;
  rdfs:label "whole genome sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that intends to provide information about the sequence of an entire genome of an organism." ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:NCBITaxon_2759 a rdfs:Class ;
  rdfs:label "Eukaryota" ;
  rdfs:subClassOf obo:OBI_0100026 .

obo:CL_0002116 a rdfs:Class ;
  rdfs:label "B220-low CD38-positive unswitched memory B cell" ;
  rdfs:subClassOf obo:CL_0002114 .

obo:CL_0000866 a rdfs:Class ;
  rdfs:label "thymic macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:OBI_0002526 a rdfs:Class ;
  rdfs:label "skin of body specimen" ;
  rdfs:comment "A specimen that is derived from skin." ;
  rdfs:subClassOf obo:OBI_0001479 .

<http://semanticscience.org/resource/SIO_000811> a rdfs:Class ;
  rdfs:label "URL"@en ;
  rdfs:comment "A Uniform Resource Locator or Universal Resource Locator (URL) is a specific character string that constitutes a reference to an Internet resource."@en ;
  rdfs:subClassOf obo:IAO_0000577 .

obo:OBI_0002026 a rdfs:Class ;
  rdfs:label "Human Genome U133 tiling array" ;
  rdfs:comment "A tiling array which is manufactured by the Affymetrix corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for human DNA against 39,000 transcripts and variants." ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OMIABIS_0000014 a rdfs:Class ;
  rdfs:label "name of biobank contact person"@en ;
  rdfs:comment "A personal name that designates the person acting as contact for a sample collection or a study."@en ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:CL_0000987 a rdfs:Class ;
  rdfs:label "IgA plasma cell" ;
  rdfs:subClassOf obo:CL_0000974 .

obo:CL_0002356 a rdfs:Class ;
  rdfs:label "primitive reticulocyte" ;
  rdfs:subClassOf obo:CL_0002417 .

obo:NGBO_6000352 a rdfs:Class ;
  rdfs:label "raw sequence file editing"@en ;
  rdfs:comment "A bioinformatics analysis which involves any edit or change to a molecular sequence file." ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:NGBO_6000233 a rdfs:Class ;
  rdfs:label "format validation"@en ;
  rdfs:comment "A data validation process that checks that the data is in a specified format (template), e.g., dates have to be in the format DD/ MM/YYYY is correct" ;
  rdfs:subClassOf obo:NGBO_6000232 .

obo:CL_0001030 a rdfs:Class ;
  rdfs:label "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor" ;
  rdfs:subClassOf obo:CL_0002032 .

obo:OBIB_0000240 a rdfs:Class ;
  rdfs:label "name of person receiving blood specimen in laboratory" ;
  rdfs:comment "A personal name that designates the person who received a blood specimen in the laboratory." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:BTO_0000583 a rdfs:Class ;
  rdfs:label "bone marrow cancer cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0005934> .

<http://semanticscience.org/resource/SIO_000181> a rdfs:Class ;
  rdfs:label "first name"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000116> .

obo:OBIB_0000600 a rdfs:Class ;
  rdfs:label "clinical history of Alzheimer's disease" ;
  rdfs:comment "A clinical history in which there is a history of Alzheimer's Disease." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002539 a rdfs:Class ;
  rdfs:label "tibial nerve specimen" ;
  rdfs:comment "A specimen that is derived from tibial nerve." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000245 a rdfs:Class ;
  rdfs:label "organization"@en ;
  rdfs:comment "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000849 a rdfs:Class ;
  rdfs:label "organellar RNA extraction" ;
  rdfs:comment "A RNA extraction process in which the desired output material is RNA in the organelle(s)." ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OMIABIS_0000037 a rdfs:Class ;
  rdfs:label "study proper name"@en ;
  rdfs:comment "A proper name that designates a study."@en ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:OBIB_0000549 a rdfs:Class ;
  rdfs:label "clinical history of fungal infections" ;
  rdfs:comment "A clinical history in which there is a history of fungal infections." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBIB_0000507 a rdfs:Class ;
  rdfs:label "lifelong non-drinker of alcohol" ;
  rdfs:comment "An Alcohol Use History in which there is no alcohol consumption." ;
  rdfs:subClassOf obo:NCIT_C81229 .

obo:PO_0020099 a rdfs:Class ;
  rdfs:label "microgametophyte vegetative cell" ;
  rdfs:comment "A native plant cell (PO:0025606) that is the larger cell of a microgametophyte (PO:0025280) in seed plants. It does not divide further and develops into a pollen tube cell (PO:0025195)." ;
  rdfs:subClassOf obo:PO_0025606 .

obo:CL_0000451 a rdfs:Class ;
  rdfs:label "dendritic cell" ;
  rdfs:comment "A special type of cell that is a key regulator of the immune system, acting as a professional antigen-presenting cell, APC, capable of activating naive T cells and stimulating the growth and differentiation of B cells. Dendritic cells are found, for example, in the lymph nodes and spleen. As an APC, a dendritic cell can retain antigen for long periods on its surface, present the antigen to a T or B cell and so influence their behavior." ;
  rdfs:subClassOf obo:CL_0000738 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002578 a rdfs:Class ;
  rdfs:label "adapter sequence data" ;
  rdfs:comment "Nucleotide sequences of molecules that are ligated to assay samples prior to sequencing of these samples;  these sequences are provided by assay kit manufacturers and typically used to combine sequencing of multiple samples in one assay run." ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBIB_0000564 a rdfs:Class ;
  rdfs:label "clinical history of osteomyelitis" ;
  rdfs:comment "A clinical history in which there is a history of osteomyelitis." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000888 a rdfs:Class ;
  rdfs:label "lymph node tingible body macrophage" ;
  rdfs:subClassOf obo:CL_0000868 .

obo:OMIABIS_0000007 a rdfs:Class ;
  rdfs:label "ISO 3166-1 alpha-2 code for sample collection or study contact"@en ;
  rdfs:comment "The ISO 3166-1 alpha-2 code that is part of the sample collection or study contact's postal address."@en ;
  rdfs:subClassOf obo:OMIABIS_0000004 .

obo:PATO_0001894 a rdfs:Class ;
  rdfs:label "phenotypic sex" ;
  rdfs:comment "An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics." ;
  rdfs:subClassOf obo:PATO_0000047 .

obo:CL_0000333 a rdfs:Class ;
  rdfs:label "neural crest cell" ;
  rdfs:comment "A cell of the strip of specialized ectoderm flanking each side of the embryonal neural plate, which after the closure of the neural tube, forms a column of isolated cells along the dorsal aspect of the neural tube. Most of the cranial and all of the spinal sensory ganglion cells arise by differentiation of neural crest cells." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002514 a rdfs:Class ;
  rdfs:label "peritoneal fluid specimen" ;
  rdfs:comment "A specimen that is derived from peritoneal fluid." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000579 a rdfs:Class ;
  rdfs:label "border follicle cell" ;
  rdfs:comment "A follicle cell that migrates from the anterior pole of the egg chamber, between the nurse cells, to the anterior of the oocyte where they participate in formation of the micropyle. About 6-10 border cells per egg chamber migrate as a tightly associated cluster." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002048 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 3000" ;
  rdfs:comment "A DNA sequencer manufactured by Illumina corporation, with a single flow cell and a throughput of more than 200 Gb per day." ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:CL_0002057 a rdfs:Class ;
  rdfs:label "CD14-positive, CD16-negative classical monocyte" ;
  rdfs:subClassOf obo:CL_0000860 .

obo:OBI_0001175 a rdfs:Class ;
  rdfs:label "selective organism creation objective"@en ;
  rdfs:comment "an objective specification to generate a population or type of organism within species that have some uniform behavioral, morphological, physiological, or genetic characteristics with similarly bred organisms." ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0000415 a rdfs:Class ;
  rdfs:label "polymerase chain reaction"@en ;
  rdfs:comment "PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified."@en ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:NGBO_6000289 a rdfs:Class ;
  rdfs:label "Availability of other specimen from the same donor"@en ;
  rdfs:comment "A data item which represent the availability of other specimen from the same donor" ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:CL_0002457 a rdfs:Class ;
  rdfs:label "epidermal Langerhans cell" ;
  rdfs:subClassOf obo:CL_0000453 .

obo:CL_0000041 a rdfs:Class ;
  rdfs:label "mature eosinophil" ;
  rdfs:subClassOf obo:CL_0000771 .

obo:OBI_0000855 a rdfs:Class ;
  rdfs:label "total RNA extraction" ;
  rdfs:comment "A RNA extraction process in which total cellular and organelle RNA are extracted." ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:CL_0002363 a rdfs:Class ;
  rdfs:label "keratocyte" ;
  rdfs:comment "A keratocyte is a specialized fibroblast residing in the stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components.  This cell type secretes collagen I, V, VI, and keratin sulfate." ;
  rdfs:subClassOf obo:CL_0000057 .

obo:OBIB_0000039 a rdfs:Class ;
  rdfs:label "blood specimen on blood spot card"@en ;
  rdfs:comment "A blood specimen that is located on a blood spot card." ;
  rdfs:subClassOf obo:OBI_0000655 , obo:OBI_0000953 .

obo:OBIB_0000131 a rdfs:Class ;
  rdfs:label "in vivo intraoperative ischemic period" ;
  rdfs:comment "A time measurement datum of the period between organ resection and the time of first clamping perfomed in vivo." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:CL_0001015 a rdfs:Class ;
  rdfs:label "CD8_alpha-low Langerhans cell" ;
  rdfs:subClassOf obo:CL_0000453 .

obo:CL_0005019 a rdfs:Class ;
  rdfs:label "pancreatic epsilon cell" ;
  rdfs:comment "Ghrelin secreting cells found in the found in the exocrine pancreas." ;
  rdfs:subClassOf obo:CL_0000151 , <http://www.ebi.ac.uk/efo/EFO_0002966> .

obo:CL_0002468 a rdfs:Class ;
  rdfs:label "Gr1-low myeloid suppressor cell" ;
  rdfs:subClassOf obo:CL_0000889 .

obo:OBI_0001900 a rdfs:Class ;
  rdfs:label "specimen identifier assigned by specimen repository"@en ;
  rdfs:comment "A specimen identifier which is assigned by a specimen repository" ;
  rdfs:subClassOf obo:NGBO_6000161 , obo:OBI_0001616 .

obo:OBIB_0000481 a rdfs:Class ;
  rdfs:label "relationship between person signing research authorization and specimen donor" ;
  rdfs:comment "A relationship that may be biological or legal, between the specimen donor and the legally authorized representative who signed the research authorization." ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:CL_0002154 a rdfs:Class ;
  rdfs:label "early promyelocyte" ;
  rdfs:subClassOf obo:CL_0000836 .

<http://semanticscience.org/resource/SIO_000182> a rdfs:Class ;
  rdfs:label "last name"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000116> .

obo:CL_0002016 a rdfs:Class ;
  rdfs:label "CD71-low, GlyA-positive polychromatic erythroblast" ;
  rdfs:subClassOf obo:CL_0000550 .

obo:NGBO_6000397 a rdfs:Class ;
  rdfs:label "target sequence information"@en ;
  rdfs:comment "A data item that which represent information about subset of genes or specific regions of interest of the genome." ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:NGBO_6000198 a rdfs:Class ;
  rdfs:label "single molecule real time sequencing data"@en ;
  rdfs:comment "A single molecule real time sequencing data is DNA sequence data generated from parallelized single molecule DNA sequencing method."@en ;
  rdfs:subClassOf obo:OBI_0001573 .

obo:NGBO_6000278 a rdfs:Class ;
  rdfs:label "result acceptance or rejection protocol"@en ;
  rdfs:comment "Protocol for acceptence or rejcetion must be based on metrics and quality control parameters established during test optimization and utilized during validation" ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:OBI_0002391 a rdfs:Class ;
  rdfs:label "exposure to second hand smoke in household during childhood" ;
  rdfs:comment "An exposure to second hand smoke that occurred in the (patient's) household when the person was a child." ;
  rdfs:subClassOf obo:OBI_0002390 .

obo:CL_0000840 a rdfs:Class ;
  rdfs:label "immature conventional dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:SO_0000276 a rdfs:Class ;
  rdfs:label "miRNA" ;
  rdfs:comment "Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:OBI_0001690 a rdfs:Class ;
  rdfs:label "molecular function identification objective"@en ;
  rdfs:comment "is an objective specification which aims to discover molecular function realized by a molecular entity"@en ;
  rdfs:subClassOf obo:OBI_0000015 .

obo:OBI_0002380 a rdfs:Class ;
  rdfs:label "uncle clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male sibling of a parent." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBIws_0000192 a rdfs:Class ;
  rdfs:label "RNA sequence data"@en ;
  rdfs:comment "A sequence data that is about the primary structure of RNA."@en ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:OBI_0000806 a rdfs:Class ;
  rdfs:label "material maintenance objective" ;
  rdfs:comment "An objective specification maintains some or all of the qualities of a material over time." ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:NCIT_C40978 a rdfs:Class ;
  rdfs:label "Telephone Number" ;
  rdfs:comment "A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network." ;
  rdfs:subClassOf obo:IAO_0000577 , obo:NGBO_6000161 .

obo:OBI_0400103 a rdfs:Class ;
  rdfs:label "DNA sequencer"@en ;
  rdfs:comment "A DNA sequencer is an instrument that determines the order of deoxynucleotides in deoxyribonucleic acid sequences."@en ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:CL_0002035 a rdfs:Class ;
  rdfs:label "Slamf1-negative multipotent progenitor cell" ;
  rdfs:subClassOf obo:CL_0000837 .

obo:NGBO_6000318 a rdfs:Class ;
  rdfs:label "expression quantitative trait loci"@en ;
  rdfs:comment "A genomic feature location which represent the expression quantitative trait loci are genomic loci that explain all or a fraction of variation in expression levels of mRNAs"@en ;
  rdfs:subClassOf obo:GENO_0000902 .

obo:OBI_0000444 a rdfs:Class ;
  rdfs:label "target of material addition role"@en ;
  rdfs:comment "target of material addition role is a role realized by an entity into which a material is added in a material addition process" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000038 a rdfs:Class ;
  rdfs:label "chromatography column"@en ;
  rdfs:comment "Chromatography column in chemistry is a tube and contents (typically glass) used to purify individual chemical compounds from mixtures of compounds. It is often used for preparative applications on scales from micrograms up to kilograms."@en ;
  rdfs:subClassOf obo:OBI_0000932 .

obo:CL_0002475 a rdfs:Class ;
  rdfs:label "lymphoid MHC-II-negative non-classical monocyte" ;
  rdfs:subClassOf obo:CL_0002471 .

<http://www.ebi.ac.uk/efo/EFO_0000700> a rdfs:Class ;
  rdfs:label "integumental cell" ;
  rdfs:comment "Cell coming from the intergument, organ that constitutes the external surface of the body. The intergument consists of the epidermis, dermis, and skin appendages." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0302886 a rdfs:Class ;
  rdfs:label "centrifugation"@en ;
  rdfs:comment "centrifugation is a process separating molecules by size or density using centrifugal forces generated by a spinning rotor. G-forces of several hundred thousand times gravity are generated in ultracentrifugation"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0002470 a rdfs:Class ;
  rdfs:label "bcl2fastq software application"@en ;
  rdfs:comment "A base calling application that implments a base calling algorithm to convert BCL (binary base call) files generated by Illumina sequencing systems to standard FASTQ file formats for downstream analysis."@en ;
  rdfs:subClassOf obo:OBI_0002469 .

obo:NGBO_6000166 a rdfs:Class ;
  rdfs:label "protein sequencing"@en ;
  rdfs:comment "A sequencing assay which involves the determination of the arrangement of the amino acid sequence of a protein." ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:CL_0000632 a rdfs:Class ;
  rdfs:label "hepatic stellate cell" ;
  rdfs:comment """
A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver.
""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0001063 a rdfs:Class ;
  rdfs:label "automatic staining machine" ;
  rdfs:comment "A device that is used to automatically stain tissue sections on slides or tissue specimens." ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:CL_0000771 a rdfs:Class ;
  rdfs:label "eosinophil" ;
  rdfs:comment "Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin." ;
  rdfs:subClassOf obo:CL_0000094 .

obo:IAO_0000109 a rdfs:Class ;
  rdfs:label "measurement datum"@en ;
  rdfs:comment "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBIB_0000583 a rdfs:Class ;
  rdfs:label "clinical history of sexually transmitted disease" ;
  rdfs:comment "A clinical history in which there is a history of sexually transmitted diseases" ;
  rdfs:subClassOf obo:OGMS_0000015 .

<http://www.ebi.ac.uk/efo/EFO_0002572> a rdfs:Class ;
  rdfs:label "large adipocyte" ;
  rdfs:subClassOf obo:CL_0000136 .

<http://semanticscience.org/resource/SIO_000079> a rdfs:Class ;
  rdfs:label "visual language entity"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000078> .

<http://www.ebi.ac.uk/efo/EFO_0002963> a rdfs:Class ;
  rdfs:label "nervous system cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000949 a rdfs:Class ;
  rdfs:label "accessed material role" ;
  rdfs:comment "is realized in a planned process where the bearer participates" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:CL_0000553 a rdfs:Class ;
  rdfs:label "megakaryocyte progenitor cell" ;
  rdfs:comment "The earliest cytologically identifiable precursor in the thrombocytic series." ;
  rdfs:subClassOf obo:CL_0000839 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002128 a rdfs:Class ;
  rdfs:label "Illumina Genome Analyzer"@en ;
  rdfs:comment "A DNA sequencer manufactured by Solexa as one of its first sequencer lines, launched in 2006, and capable of sequencing 1 gigabase (Gb) of data in a single run."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0000574 a rdfs:Class ;
  rdfs:label "high temperature column"@en ;
  rdfs:comment "A high temperature column is a chromatography column which is suitable for and withstands very high temperatures in chromatography ovens."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CL_0000202 a rdfs:Class ;
  rdfs:label "cochlear hair cell" ;
  rdfs:comment "A mechanoreceptor cell located in the organ of Corti that is sensitive to auditory stimuli and in the vestibular apparatus that is sensitive to movement of the head. In each case the accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000023 a rdfs:Class ;
  rdfs:label "oocyte" ;
  rdfs:comment "A female germ cell that has entered meiosis." ;
  rdfs:subClassOf obo:CL_0000586 .

obo:OBI_0600004 a rdfs:Class ;
  rdfs:label "human subject enrollment"@en ;
  rdfs:comment "A planned process with the objective to obtain a population of human subjects to participate in an investigation by determining eligibility of subjects and obtaining informed consent."@en ;
  rdfs:subClassOf obo:OBI_0001928 .

obo:CL_0000292 a rdfs:Class ;
  rdfs:label "guard cell" ;
  rdfs:comment "One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0200189 a rdfs:Class ;
  rdfs:label "merging objective"@en ;
  rdfs:comment "A merging objective is a data transformation objective in which the data transformation has the aim of performing a union of two or more sets."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0002194 a rdfs:Class ;
  rdfs:label "monopoietic cell" ;
  rdfs:subClassOf obo:CL_0000839 .

obo:OBI_0002690 a rdfs:Class ;
  rdfs:label "insecticide resistance detection objective" ;
  rdfs:comment "An organism feature identification objective that aims to detect insecticide resistance of an insect." ;
  rdfs:subClassOf obo:OBI_0000268 .

obo:ICO_0000023 a rdfs:Class ;
  rdfs:label "completely filled informed consent form" ;
  rdfs:comment "an informed consent form that has been filled with all required contents." ;
  rdfs:subClassOf obo:ICO_0000001 .

obo:PATO_0001340 a rdfs:Class ;
  rdfs:label "hermaphrodite" ;
  rdfs:comment "An organism having both male and female sexual characteristics and organs." ;
  rdfs:subClassOf obo:PATO_0000047 , obo:PATO_0001894 .

obo:OBI_0000653 a rdfs:Class ;
  rdfs:label "fuzzy clustering objective"@en ;
  rdfs:comment "A fuzzy clustering objective is a data transformation objective where the aim is to assign input objects (typically vectors of attributes) a probability that a point belongs to a class, where the number of class and their specifications are not known a priori."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:BTO_0002842 a rdfs:Class ;
  rdfs:label "cholangioma cell" ;
  rdfs:comment "A rare type of hepatocellular carcinoma arising from the cholangioles, composed of tumor cells resembling the epithelial cells of the cholangioles arranged in cords consisting of two layers of cells surrounding a minute lumen." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0005934> .

obo:NGBO_6000244 a rdfs:Class ;
  rdfs:label "reference genome datum"@en ;
  rdfs:comment "A data item which represent datum related to reference genome used as a standard for comparison in basic research and clinical settings"@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBIB_0000205 a rdfs:Class ;
  rdfs:label "name of dissector of parent specimen" ;
  rdfs:comment "A personal name that designates the person who performed the dissection of a surgical specimen to create a specimen family." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001047 a rdfs:Class ;
  rdfs:label "pH meter" ;
  rdfs:comment "A device that is used to measure the pH (acidity or alkalinity) of a liquid." ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:CL_0002327 a rdfs:Class ;
  rdfs:label "mammary epithelial cell" ;
  rdfs:comment "An epithelial cell of the mammary gland." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:CL_0000980 a rdfs:Class ;
  rdfs:label "plasmablast" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:OBIB_0000596 a rdfs:Class ;
  rdfs:label "clinical history of scleroderma" ;
  rdfs:comment "A clinical history in which there is a history of scleroderma." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0100017 a rdfs:Class ;
  rdfs:label "blood serum specimen"@en ;
  rdfs:comment "A material entity which derives from blood and corresponds to blood plasma without fibrinogen or the other clotting factors."@en ;
  rdfs:subClassOf obo:OBI_0000953 .

obo:CL_0002410 a rdfs:Class ;
  rdfs:label "pancreatic stellate cell" ;
  rdfs:comment "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." ;
  rdfs:subClassOf obo:CL_0000057 , <http://www.ebi.ac.uk/efo/EFO_0002966> .

obo:CL_0002619 a rdfs:Class ;
  rdfs:label "adult endothelial progenitor cell" ;
  rdfs:comment "An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial. [ GOC:tfm PMID:20807818 PMID:9020076 ] " ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000586> .

obo:OMIABIS_0000052 a rdfs:Class ;
  rdfs:label "fixed tissue slide specimen"@en ;
  rdfs:comment "A fixed tissue specimen that is placed in a slide."@en ;
  rdfs:subClassOf obo:OMIABIS_0000050 .

obo:CL_0002024 a rdfs:Class ;
  rdfs:label "Kit-positive megakaryocyte progenitor cell" ;
  rdfs:subClassOf obo:CL_0000553 .

obo:OBIB_0000150 a rdfs:Class ;
  rdfs:label "Duration of fasting by specimen donor prior to surgery" ;
  rdfs:comment "A time measurement datum of the duration of fasting by the specimen donor prior to surgery." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0001916 a rdfs:Class ;
  rdfs:label "DNA replication identification objective"@en ;
  rdfs:comment "A molecular feature identification objective that aims to examine charateristics of DNA replication, such as replication time." ;
  rdfs:subClassOf obo:OBI_0000131 .

obo:NGBO_6000227 a rdfs:Class ;
  rdfs:label "command line flag"@en ;
  rdfs:comment "A symbol that is used to specify options for command line programs." ;
  rdfs:subClassOf obo:IAO_0000028 .

obo:OMIABIS_0001040 a rdfs:Class ;
  rdfs:label "specimen meeting specification"@en ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:ICO_0000089 a rdfs:Class ;
  rdfs:label "actual duration of study subject participation"@en ;
  rdfs:comment "Total length of time of subject's participation in a clinical study; from the time of enrollment to the completion of follow-up." ;
  rdfs:subClassOf obo:ICO_0000088 .

obo:OBI_0002033 a rdfs:Class ;
  rdfs:label "translation-associated transcript leader sequencing assay" ;
  rdfs:comment "An RNA-seq assay that combines TL-seq with polysome fractionation" ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:CL_0002352 a rdfs:Class ;
  rdfs:label "gestational hematopoietic stem cell" ;
  rdfs:subClassOf obo:CL_0000037 .

obo:OBIB_0000445 a rdfs:Class ;
  rdfs:label "additional tumor specimen was obtained and processed with a particular FFPE fixation delay protocol" ;
  rdfs:comment "An information content entity that is an indicator of whether a tumor specimen was obtained and processed with a particular FFPE fixation delay protocol other than meeting the top priority for tissue procurement." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:CL_0002454 a rdfs:Class ;
  rdfs:label "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell" ;
  rdfs:subClassOf obo:CL_0002465 .

obo:CL_0000588 a rdfs:Class ;
  rdfs:label "odontoclast" ;
  rdfs:subClassOf obo:CL_0000092 .

obo:CL_2000074 a rdfs:Class ;
  rdfs:label "splenocyte" ;
  rdfs:comment "Any leukocyte that is part of a spleen. [ GOC:TermGenie ] " ;
  rdfs:subClassOf obo:CL_0000738 .

obo:OBI_0001943 a rdfs:Class ;
  rdfs:label "software pipeline"@en ;
  rdfs:comment "A plan specification that specifies a chain encoded in software of processing elements (processes, threads, coroutines, etc.), arranged so that the output of each element is the input of the next. Usually some amount of buffering is provided between consecutive elements." ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:NGBO_6000212 a rdfs:Class ;
  rdfs:label "genetic variants filtration assay"@en ;
  rdfs:comment "An assay which attempt to select highly confident variants and remove the ones that are falsely called" ;
  rdfs:subClassOf obo:NGBO_6000261 .

obo:OBI_0000515 a rdfs:Class ;
  rdfs:label "chromatofocusing column"@en ;
  rdfs:comment "A chromatofocusing column is a chromatography column in which a resin is equilibrated at one pH and eluted at a second pH. The use of a weak ion-exchange resin causes a pH gradient to be formed at the solvent front owing to the buffering action of the resin. This pH gradient in turn leads to an ordering of proteins by isoelectric point. Molecules of charge sign opposite the resin bind; those of charge sign like the resin do not bind."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:CL_0002399 a rdfs:Class ;
  rdfs:label "CD1c-positive myeloid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000782 .

obo:CL_0002103 a rdfs:Class ;
  rdfs:label "IgG-positive double negative memory B cell" ;
  rdfs:subClassOf obo:CL_0000981 .

obo:NGBO_0000063 a rdfs:Class ;
  rdfs:label "ACMG strong variants classification"@en ;
  rdfs:comment "ACMG guidelines for classification of variants of strong variants classification" ;
  rdfs:subClassOf obo:NGBO_6000355 .

obo:OBI_0002044 a rdfs:Class ;
  rdfs:label "RNA Bind-n-Seq assay" ;
  rdfs:comment "An RNA-seq assay that comprehensively characterizes sequence and structural specificity of RNA binding proteins (RBPs)." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBI_0002011 a rdfs:Class ;
  rdfs:label "Human 2.1M Whole-Genome CGH Tiling Array v2.0" ;
  rdfs:comment "An autolysis value specification that indicates moderate autolytic destruction of an organism cells or tissues." ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:OBI_0002118 a rdfs:Class ;
  rdfs:label "exome sequencing assay" ;
  rdfs:comment "A DNA sequencing assay that intends to provide information about the sequence of the protein coding components of a genome (exons)." ;
  rdfs:subClassOf obo:OBI_0000626 .

obo:OBI_0002574 a rdfs:Class ;
  rdfs:label "RNA extraction with polyA depletion" ;
  rdfs:comment "A RNA extraction process in which only RNAs lacking a polyA tail are retained" ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:CL_0000169 a rdfs:Class ;
  rdfs:label "type B pancreatic cell" ;
  rdfs:comment "A cell that secretes insulin and is located towards the center of the islets of Langerhans." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0002966> .

obo:CL_0002092 a rdfs:Class ;
  rdfs:label "bone marrow cell" ;
  rdfs:comment "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. [ GOC:tfm ISBN:0618947256 ] " ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0001101 a rdfs:Class ;
  rdfs:label "electronic repeater pipette" ;
  rdfs:comment "A micropipette that can be programmed by the user to aspirate a volume of liquid reagent or sample and dispense a series of aliquots in successive dispensing operations." ;
  rdfs:subClassOf obo:OBI_0001128 .

obo:CL_0000222 a rdfs:Class ;
  rdfs:label "mesodermal cell" ;
  rdfs:comment "A cell of the middle germ layer of the embryo." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002506 a rdfs:Class ;
  rdfs:label "pericardial fluid specimen" ;
  rdfs:comment "A specimen that is derived from pericardial fluid." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OMIABIS_0000000 a rdfs:Class ;
  rdfs:label "biobank"@en ;
  rdfs:comment """A biobank is a collections of samples of biological substances
(e.g. tissue, blood, DNA) which are linked to data about the samples and their donors. They have a dual nature as collections of samples and data."""@en ;
  rdfs:subClassOf obo:BFO_0000027 .

obo:CL_0002013 a rdfs:Class ;
  rdfs:label "GlyA-positive basophillic erythroblast" ;
  rdfs:subClassOf obo:CL_0000549 .

obo:OBI_0200197 a rdfs:Class ;
  rdfs:label "spectrum analysis objective" ;
  rdfs:comment "is a data transformation objective where the aim is to analyse some aspect of spectral data by some data transformation process. " ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0200186 a rdfs:Class ;
  rdfs:label "error correction objective"@en ;
  rdfs:comment "An error correction objective is a data transformation objective where the aim is to remove (correct for) erroneous contributions arising from the input data, or the transformation itself."@en ;
  rdfs:subClassOf obo:OBI_0200168 .

obo:CL_0000056 a rdfs:Class ;
  rdfs:label "myoblast" ;
  rdfs:comment "An embryonic (precursor) cell of the myogenic lineage that develops from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000675 a rdfs:Class ;
  rdfs:label "statistical hypothesis test objective"@en ;
  rdfs:comment "is a data transformation objective where the aim is to estimate statistical significance with the aim of proving or disproving a hypothesis by means of some data transformation " ;
  rdfs:subClassOf obo:OBI_0200166 .

<http://www.ebi.ac.uk/efo/EFO_0002958> a rdfs:Class ;
  rdfs:label "experimental cell" ;
  rdfs:comment "experimental cell is a cell which is experimentally derived such as a cell line cell, or a cell differentiated in culture. Experimentally derived cells may have diffrent properties from the cell from which they originally derived, such as through gene expression changes." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OMIT_0025630 a rdfs:Class ;
  rdfs:label "DNA Fragmentation" ;
  rdfs:comment "DNA fragmentation is the separation or breaking of DNA strands into pieces. It can be done intentionally by laboratory personnel or by cells, or can occur spontaneously" ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:OBI_0002528 a rdfs:Class ;
  rdfs:label "stomach specimen" ;
  rdfs:comment "A specimen that is derived from stomach." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0002421 a rdfs:Class ;
  rdfs:label "nucleated reticulocyte" ;
  rdfs:subClassOf obo:CL_0000558 .

obo:OBI_0000993 a rdfs:Class ;
  rdfs:label "service provision objective" ;
  rdfs:comment "An objective which is fulfilled by the provision of some service e.g. a training service" ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0000960 a rdfs:Class ;
  rdfs:label "reagent application function" ;
  rdfs:comment "A function that is realized when a reagent is automatically added to some research material." ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBIB_0000544 a rdfs:Class ;
  rdfs:label "clinical history of pneumonia" ;
  rdfs:comment "A clinical history in which there is a history of pneumonia." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000211 a rdfs:Class ;
  rdfs:label "electrically active cell" ;
  rdfs:comment """
A cell whose function is determined by the generation or the reception of an electric signal.
""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0001880 a rdfs:Class ;
  rdfs:label "organization of specimen provider principal investigator"@en ;
  rdfs:comment "An organization that is the affiliation of the principal investigator providing the specimens for the investigation" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:OGMS_0000023 a rdfs:Class ;
  rdfs:label "phenotype" ;
  rdfs:comment "A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species."@en ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:OBI_0000868 a rdfs:Class ;
  rdfs:label "pattern matching objective" ;
  rdfs:comment "A pattern matching objective aims to detect the presence of the constituents of a given pattern. In contrast to pattern recognition, the pattern is rigidly specified. Patterns are typicall sequences or trees." ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBI_0002457 a rdfs:Class ;
  rdfs:label "precision nuclear run-on sequencing assay" ;
  rdfs:comment "An RNA-seq assay that maps the genome-wide distribution of transcriptionally-engaged Pol II at base-pair resolution by using biotin-labeled ribonucleotide triphosphate analogs (biotin-NTP) for nuclear run-on reactions, allowing the efficient affinity purification of nascent RNAs for high throughput sequencing from their 3' ends." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:OBIB_0000566 a rdfs:Class ;
  rdfs:label "clinical history of unexplained weakness and fatigue" ;
  rdfs:comment "A clinical history in which there is a history of unexplained weakness and fatigue described as flu-like symptoms." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:PO_0009002 a rdfs:Class ;
  rdfs:label "plant cell" ;
  rdfs:comment "A cell which is a plant structure (PO:0009011)." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002554 a rdfs:Class ;
  rdfs:label "vagina specimen" ;
  rdfs:comment "A specimen that is derived from vagina." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0600052 a rdfs:Class ;
  rdfs:label "dialysis"@en ;
  rdfs:comment "a protocol application that uses diffusion through a semi-permeable membrane to separate an input material into two fractions of different composition"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBIB_0000555 a rdfs:Class ;
  rdfs:label "clinical history of smallpox vaccination" ;
  rdfs:comment "A clinic history in which there is a history  of a recent of smallpox vaccination." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000122 a rdfs:Class ;
  rdfs:label "bioinformatics analysis"@en ;
  rdfs:comment "A data transformation which involeves curation, processing and analysis of complex biological data" ;
  rdfs:subClassOf obo:OBI_0200000 .

obo:CL_0000951 a rdfs:Class ;
  rdfs:label "IgE short lived plasma cell" ;
  rdfs:subClassOf obo:CL_0000975 .

obo:CL_0000884 a rdfs:Class ;
  rdfs:label "mucosa-associated lymphoid tissue macrophage" ;
  rdfs:subClassOf obo:CL_0000867 .

obo:CL_0000976 a rdfs:Class ;
  rdfs:label "IgA short lived plasma cell" ;
  rdfs:subClassOf obo:CL_0000975 .

obo:OBI_0400107 a rdfs:Class ;
  rdfs:label "computer"@en ;
  rdfs:comment "A computer is an instrument which manipulates (stores, retrieves, and processes) data according to a list of instructions."@en ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:OBI_0002553 a rdfs:Class ;
  rdfs:label "uterus specimen" ;
  rdfs:comment "A specimen that is derived from uterus." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0000924 a rdfs:Class ;
  rdfs:label "labeled specimen" ;
  rdfs:comment "A specimen  that has been modified in order to be able to detect it in future experiments" ;
  rdfs:subClassOf obo:OBI_0000953 , obo:OBI_0001936 .

<http://semanticscience.org/resource/SIO_000136> a rdfs:Class ;
  rdfs:label "description"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000078> .

obo:CL_0000515 a rdfs:Class ;
  rdfs:label "skeletal muscle myoblast"@en ;
  rdfs:comment "A myoblast that differentiates into skeletal muscle fibers." ;
  rdfs:subClassOf obo:CL_0000056 .

obo:NGBO_6000246 a rdfs:Class ;
  rdfs:label "data file URL"@en ;
  rdfs:comment "A URL at which the data file file is stored." ;
  rdfs:subClassOf obo:NGBO_6000385 , <http://semanticscience.org/resource/SIO_000811> .

obo:OBI_0000015 a rdfs:Class ;
  rdfs:label "biological feature identification objective"@en ;
  rdfs:comment "Biological_feature_identification_objective is an objective role carried out by the proposition defining the aim of a study designed to examine or characterize a particular biological feature."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBIB_0000343 a rdfs:Class ;
  rdfs:label "manual FFPE tissue section H&E clearing" ;
  rdfs:comment "A planned process involving the manual performance of the FFPE tissue section H&E clearing protocol." ;
  rdfs:subClassOf obo:OMIABIS_0000911 .

<http://www.ebi.ac.uk/efo/EFO_0002665> a rdfs:Class ;
  rdfs:label "monocyte-derived intermediate cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0000570 a rdfs:Class ;
  rdfs:label "spin column"@en ;
  rdfs:comment "A spin column is a chromatography column which is suitable for putting it into a centrifuge. A spin column enforces separation through increased G-forces while spinning the column in a centrifuge. It is often used in DNA gel extraction kits."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:NGBO_6000305 a rdfs:Class ;
  rdfs:label "variant of unknown significance"@en ;
  rdfs:comment "A clinical variant interpretation that represents a sequence variant that is previously unreported and is of the type which may or may not be causative of the disorder." ;
  rdfs:subClassOf obo:NGBO_6000302 .

obo:NGBO_6000006 a rdfs:Class ;
  rdfs:label "FASTA format"@en ;
  rdfs:comment "A file format which represent represent a text-based format for representing either nucleotide sequences or peptide sequences, in which base pairs or amino acids are represented using single-letter codes" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:IAO_0000010 a rdfs:Class ;
  rdfs:label "software"@en ;
  rdfs:comment """Software is a plan specification composed of a series of instructions that can be 
interpreted by or directly executed by a processing unit."""@en ;
  rdfs:subClassOf obo:IAO_0000104 .

obo:CL_0000171 a rdfs:Class ;
  rdfs:label "pancreatic A cell" ;
  rdfs:comment "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." ;
  rdfs:subClassOf obo:CL_0000066 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0302885 a rdfs:Class ;
  rdfs:label "filtration"@en ;
  rdfs:comment "filtration is a process which separates components suspended in a fluid based on granularity properties relying on a filter device"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0000093 a rdfs:Class ;
  rdfs:label "patient role"@en ;
  rdfs:comment "a role which inheres in a person and is realized by the process of being under the care of a physician or health care provider"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:CL_0002113 a rdfs:Class ;
  rdfs:label "B220-low CD38-negative unswitched memory B cell" ;
  rdfs:subClassOf obo:CL_0002111 .

obo:OBI_0000626 a rdfs:Class ;
  rdfs:label "DNA sequencing assay" ;
  rdfs:comment "A sequencing assay which determines information on the sequence of a DNA molecule." ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:NGBO_6000273 a rdfs:Class ;
  rdfs:label "data transfer protocol"@en ;
  rdfs:comment "A protocol plan specification which describes the process of data transfer between two entities" ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:CL_0002540 a rdfs:Class ;
  rdfs:label "mesenchymal stem cell of the bone marrow" ;
  rdfs:comment "A mesenchymal stem cell that is part of the bone marrow. [ GOC:tfm ] " ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000586> .

obo:OBI_0002513 a rdfs:Class ;
  rdfs:label "placenta specimen" ;
  rdfs:comment "A specimen that is derived from placenta." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:SO_0000001 a rdfs:Class ;
  rdfs:label "region" ;
  rdfs:comment "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids." ;
  rdfs:subClassOf obo:BFO_0000031 .

obo:CL_0000991 a rdfs:Class ;
  rdfs:label "CD11c-negative plasmacytoid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000784 .

obo:OBI_0000618 a rdfs:Class ;
  rdfs:label "size exclusion column"@en ;
  rdfs:comment "A size exclusion column is a chromatography column as used in size exclusion chromatography and which enables the separation of mixtures according to differrences in molecular size."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

<http://semanticscience.org/resource/SIO_010673> a rdfs:Class ;
  rdfs:label "medical history"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_001196> .

obo:OBI_0002125 a rdfs:Class ;
  rdfs:label "H&E-stained fixed tissue slide specimen"@en ;
  rdfs:comment "A fixed tissue slide specimen that is the output of H&E slide staining."@en ;
  rdfs:subClassOf obo:OMIABIS_0000052 .

obo:OBI_0002006 a rdfs:Class ;
  rdfs:label "1M-Duo Infinium HD BeadChip" ;
  rdfs:comment "A specimen gross appearance of the most internal topographic location of the tumor." ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:IAO_0000032 a rdfs:Class ;
  rdfs:label "scalar measurement datum"@en ;
  rdfs:comment "a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

<http://www.ebi.ac.uk/efo/EFO_0003919> a rdfs:Class ;
  rdfs:label "risk factor" ;
  rdfs:comment "An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent." ;
  rdfs:subClassOf obo:BFO_0000016 .

obo:OBIB_0000273 a rdfs:Class ;
  rdfs:label "specimen receiving organization" ;
  rdfs:comment "A role borne by an organization that is the recipient of a specimen that is transported from another organization." ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBIB_0000582 a rdfs:Class ;
  rdfs:label "clinical history of opportunistic infections" ;
  rdfs:comment "A clinical history in which there is a history of opportunistic infections." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0000717 a rdfs:Class ;
  rdfs:label "HeliScope Single Molecule Sequencer" ;
  rdfs:comment "is a DNA sequencer manufacturer by Helicos Corporation to carry out Single Molecule sequencing using reversible termination chemistry" ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:CL_0000599 a rdfs:Class ;
  rdfs:label "conidium" ;
  rdfs:comment """
An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm.
""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

<http://www.ebi.ac.uk/efo/EFO_0004987> a rdfs:Class ;
  rdfs:label "embryonal carcinoma cell" ;
  rdfs:comment "A cell which bears embryonal carcinoma." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000414 a rdfs:Class ;
  rdfs:label "bioinformatics analysis execution date"@en ;
  rdfs:comment "A time measurement datum of the bioinformatics analysis execution date." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBIB_0000553 a rdfs:Class ;
  rdfs:label "clinical history of human tissue transplant" ;
  rdfs:comment "A clinical  history in which there is a history of receiving a human tissue or organ transplant ." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000099 a rdfs:Class ;
  rdfs:label "interneuron" ;
  rdfs:comment "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." ;
  rdfs:subClassOf obo:CL_0000540 .

obo:OBI_0002192 a rdfs:Class ;
  rdfs:label "Leica Peloris rapid tissue processor"@en ;
  rdfs:comment "An automatic tissue processor that is a dual retort tissue processor manufactured by the Leica company to provide fast, high quality tissue processing for histology laboratories." ;
  rdfs:subClassOf obo:OBI_0001064 .

obo:OBI_0002548 a rdfs:Class ;
  rdfs:label "omentum specimen" ;
  rdfs:comment "A specimen that is derived from omentum." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:NGBO_6000257 a rdfs:Class ;
  rdfs:label "quality assesment report"@en ;
  rdfs:comment "A report that represent the process of data collection and analysis through which the degree of conformity to predetermined standards and criteria are exemplified"@en ;
  rdfs:subClassOf obo:IAO_0000088 .

obo:OBI_0002531 a rdfs:Class ;
  rdfs:label "cortex of kidney specimen" ;
  rdfs:comment "A specimen that is derived from cortex of kidney." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002114 a rdfs:Class ;
  rdfs:label "bromouridine pulse-chase and sequencing assay" ;
  rdfs:comment "An RNA-seq assay to identify RNA populations of specific ages through isolation of RNAs first labelled with bromouridine (Bru) followed by chasing in uridine for different periods of time." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:CL_0000484 a rdfs:Class ;
  rdfs:label "connective tissue type mast cell" ;
  rdfs:subClassOf obo:CL_0000097 .

obo:OBI_0200167 a rdfs:Class ;
  rdfs:label "data normalization objective"@en ;
  rdfs:comment """A normalization objective is a data transformation objective where the aim is to remove
systematic sources of variation to put the data on equal footing in order
to create a common base for comparisons."""@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBIB_0000514 a rdfs:Class ;
  rdfs:label "current reformed smoker for more than 15 years history" ;
  rdfs:comment "A Smoking History in which there is no current smoking and has not been smoking for more than 15 years." ;
  rdfs:subClassOf obo:NCIT_C29719 .

obo:OBI_0002393 a rdfs:Class ;
  rdfs:label "pregnancy history" ;
  rdfs:comment "A clinical history in which a female has had a pregnancy." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0000436 a rdfs:Class ;
  rdfs:label "needle"@en ;
  rdfs:comment "a needle is a sharp, hollow device used to penetrate tissue or soft material. When attached to a syringe. it allows delivery of a specific volume of liquid or gaseous mixture."@en ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:CL_0000862 a rdfs:Class ;
  rdfs:label "suppressor macrophage" ;
  rdfs:subClassOf obo:CL_0000861 .

obo:CL_0000819 a rdfs:Class ;
  rdfs:label "B-1 B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:BFO_0000148 a rdfs:Class ;
  rdfs:label "zero-dimensional temporal region"@en ;
  rdfs:subClassOf obo:BFO_0000008 .

obo:OBIB_0000593 a rdfs:Class ;
  rdfs:label "clinical history of Human Immunodeficiency Virus" ;
  rdfs:comment "A clinical history in which there is a history of Human Immunodeficiency Virus (HIV)." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0002417 a rdfs:Class ;
  rdfs:label "primitive erythroid lineage cell" ;
  rdfs:subClassOf obo:CL_0000764 .

obo:IAO_0000613 a rdfs:Class ;
  rdfs:label "case report section"@en ;
  rdfs:comment "A part of a document about the medical history of a specific patient as it relates to the topic of the document."@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:PATO_0000384 a rdfs:Class ;
  rdfs:label "male" ;
  rdfs:comment "A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes." ;
  rdfs:subClassOf obo:PATO_0000047 , obo:PATO_0001894 .

obo:CL_0000125 a rdfs:Class ;
  rdfs:label "glial cell" ;
  rdfs:comment "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000873 a rdfs:Class ;
  rdfs:label "splenic metallophillic macrophage" ;
  rdfs:subClassOf obo:CL_0000871 .

obo:CL_0002204 a rdfs:Class ;
  rdfs:label "tuft cell" ;
  rdfs:comment "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:CL_0002396 a rdfs:Class ;
  rdfs:label "CD14-low, CD16-positive monocyte" ;
  rdfs:subClassOf obo:CL_0000875 .

obo:CL_0002512 a rdfs:Class ;
  rdfs:label "CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell" ;
  rdfs:subClassOf obo:CL_0002508 .

obo:PO_0004010 a rdfs:Class ;
  rdfs:label "meristematic cell" ;
  rdfs:comment "A native plant cell (PO:0025606) synthesizing protoplasm and producing new cells by division and with only a primary cell wall." ;
  rdfs:subClassOf obo:PO_0025606 .

obo:NGBO_6000320 a rdfs:Class ;
  rdfs:label "measurement datum availability statement"@en ;
  rdfs:comment "A data item which indicates availability of specimen associated data"@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:CL_0000421 a rdfs:Class ;
  rdfs:label "coelomocyte" ;
  rdfs:comment """
A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids.
""" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000973 a rdfs:Class ;
  rdfs:label "IgA memory B cell" ;
  rdfs:subClassOf obo:CL_0000972 .

obo:OBI_0000112 a rdfs:Class ;
  rdfs:label "specimen role"@en ;
  rdfs:comment "a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation"@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:CL_2000018 a rdfs:Class ;
  rdfs:label "endothelial cell of coronary artery" ;
  rdfs:comment "Any endothelial cell of artery that is part of a coronary artery. [ GOC:TermGenie ] " ;
  rdfs:subClassOf obo:CL_0000071 .

obo:OBIB_0000478 a rdfs:Class ;
  rdfs:label "name of person obtaining authorization from legally authorized representative for post-mortem specimen donation" ;
  rdfs:comment "A personal name of an individual with research obtainer role who approaches a person's legal representative and informs them of key facts about potential risks and benefits, and asks them for authorization for post-mortem specimen donation  for research for the person they legally represent." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:CL_0000081 a rdfs:Class ;
  rdfs:label "blood cell" ;
  rdfs:comment "A cell found predominately in the blood." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002543 a rdfs:Class ;
  rdfs:label "atrial appendage specimen" ;
  rdfs:comment "A specimen that is derived from the atrium auricular region." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002502 a rdfs:Class ;
  rdfs:label "cerebrospinal fluid specimen" ;
  rdfs:comment "A specimen that is derived from cerbrospinal fluid." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0001010 a rdfs:Class ;
  rdfs:label "nucleic acid extract" ;
  rdfs:comment "An extract that is the output of an extraction process in which nucleic acid molecules are isolated from a specimen." ;
  rdfs:subClassOf obo:OBI_0000423 , obo:OBI_0000953 .

obo:CL_0002020 a rdfs:Class ;
  rdfs:label "GlyA-positive reticulocytes" ;
  rdfs:subClassOf obo:CL_0002422 .

obo:OBI_0000425 a rdfs:Class ;
  rdfs:label "averaging objective"@en ;
  rdfs:comment "An averaging objective is a data transformation objective where the aim is to perform mean calculations on the input of the data transformation."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:OBIB_0000033 a rdfs:Class ;
  rdfs:label "specimen receiving"@en ;
  rdfs:comment "A planned process for receiving specimens such as into a laboratory." ;
  rdfs:subClassOf obo:OMIABIS_0001080 .

obo:OBI_0001166 a rdfs:Class ;
  rdfs:label "validation by real time PCR design"@en ;
  rdfs:comment "a study design in which the accuracy or the quality of the result of an assay is checked by comparing with real time PCR results"@en ;
  rdfs:subClassOf obo:NGBO_6000362 .

obo:OBI_0600037 a rdfs:Class ;
  rdfs:label "cell culture splitting"@en ;
  rdfs:comment "The act of taking part of a homogeneous cell culture and creating one or more additional separate cultures of similar qualities. input: cell_culture, output cell_culture min cardinality 2. part of cell culturing"@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBIB_0000365 a rdfs:Class ;
  rdfs:label "FFPE tissue cassette ID" ;
  rdfs:comment "A specimen ID that specifically identifies a particular tissue cassete used in a formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:OBI_0001616 .

obo:OBIB_0000557 a rdfs:Class ;
  rdfs:label "clinical history of dialysis" ;
  rdfs:comment "A clinical history in which there is a history of significant regular dialysis treatment." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002008 a rdfs:Class ;
  rdfs:label "Mouse 385K Whole Genome CGH Tiling Array" ;
  rdfs:comment "A tiling array which is manufactured by the Nimblegen corporation. Built to analyze DNA sequence copy number by comparative genomic hybridization for mouse DNA against 385,000 features." ;
  rdfs:subClassOf obo:OBI_0001307 .

obo:CL_0001063 a rdfs:Class ;
  rdfs:label "neoplastic cell" ;
  rdfs:comment "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0002405 a rdfs:Class ;
  rdfs:label "hormonal replacement therapy history" ;
  rdfs:comment "A clinical history in which an individual has had hormonal replacement therapy in the past." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002398 a rdfs:Class ;
  rdfs:label "hysterectomy history" ;
  rdfs:comment "A gynecologic surgery history in which a woman has had a hysterectomy." ;
  rdfs:subClassOf obo:OBI_0002397 .

obo:CL_0000768 a rdfs:Class ;
  rdfs:label "immature basophil" ;
  rdfs:subClassOf obo:CL_0000767 .

obo:NGBO_6000477 a rdfs:Class ;
  rdfs:label "expression quantitative trait loci data"@en ;
  rdfs:comment "A data item that describe expression quantitative trait loci." ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:CL_0002460 a rdfs:Class ;
  rdfs:label "CD8alpha-negative thymic conventional dendritic cell" ;
  rdfs:subClassOf obo:CL_0000941 .

obo:OBI_0666666 a rdfs:Class ;
  rdfs:label "RNA extraction"@en ;
  rdfs:comment "A RNA extraction is a nucleic acid extraction where the desired output material is RNA"@en ;
  rdfs:subClassOf obo:OBI_0666667 .

obo:CL_0000092 a rdfs:Class ;
  rdfs:label "osteoclast" ;
  rdfs:subClassOf obo:CL_0000766 .

<http://www.ebi.ac.uk/efo/EFO_1000343> a rdfs:Class ;
  rdfs:label "lympoid tissue"@en ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:IAO_0000300 a rdfs:Class ;
  rdfs:label "textual entity"@en ;
  rdfs:comment "A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc."@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000078> .

obo:BFO_0000003 a rdfs:Class ;
  rdfs:label "occurrent"@en ;
  rdfs:subClassOf obo:BFO_0000001 .

obo:OBIB_0000319 a rdfs:Class ;
  rdfs:label "FFPE tissue section preparation SOP" ;
  rdfs:comment "A standard operating procedure for the preparation of a formalin-fixed paraffin-embedded (FFPE) tissue section." ;
  rdfs:subClassOf obo:OBIB_0000070 .

obo:IAO_0000595 a rdfs:Class ;
  rdfs:label "software script"@en ;
  rdfs:comment """ A software script is software whose instructions can be executed using a software 
interpreter."""@en ;
  rdfs:subClassOf obo:IAO_0000010 .

obo:OBI_0002382 a rdfs:Class ;
  rdfs:label "grandfather clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male parent of a parent." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:NCBITaxon_33213 a rdfs:Class ;
  rdfs:label "Bilateria" ;
  rdfs:subClassOf obo:NCBITaxon_33154 .

obo:OBI_0000857 a rdfs:Class ;
  rdfs:label "complementary nucleotide probe role" ;
  rdfs:comment "A role played by a nucleic acid molecule that is used in a planned process for its ability to bind a nucleic acid molecules with complementary nucleotide sequence" ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0002022 a rdfs:Class ;
  rdfs:label "Illumina HiSeq 1000" ;
  rdfs:comment "A DNA sequencer which is manufactured by the Illumina corporation, with a single flow cell and a throughput of up to 35 Gb per day. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology." ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:NCIT_C29719 a rdfs:Class ;
  rdfs:label "Smoking History" ;
  rdfs:comment "A record of an individual's background in regard to smoking tobacco. This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others." ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_001196> .

obo:OBI_0001850 a rdfs:Class ;
  rdfs:label "transcript analysis by paired-end tag sequencing assay" ;
  rdfs:comment "A transcription profiling assay that determines transcripts, gene structures, and gene expressions using Paired-End Tags and sequencing technology." ;
  rdfs:subClassOf obo:OBI_0600047 .

obo:CL_0002608 a rdfs:Class ;
  rdfs:label "hippocampal neuron" ;
  rdfs:comment "A neuron of the hippocampus." ;
  rdfs:subClassOf obo:CL_0000540 .

obo:OBI_0002585 a rdfs:Class ;
  rdfs:label "sequence trimming" ;
  rdfs:comment "A data transformation in which subsequences of a molecular sequence are cut (removed)." ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:OBI_0600058 a rdfs:Class ;
  rdfs:label "enzymatic amplification"@en ;
  rdfs:comment "the use of enzymes to increase the number of molecules of a biomaterial"@en ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:CL_0002106 a rdfs:Class ;
  rdfs:label "IgD-positive CD38-positive IgG memory B cell" ;
  rdfs:subClassOf obo:CL_0002105 .

obo:OBIB_0000574 a rdfs:Class ;
  rdfs:label "clinical history of growth hormone use" ;
  rdfs:comment "A clinical history in which there is a history of growth hormone use." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OMIABIS_0000045 a rdfs:Class ;
  rdfs:label "biobank location ISO 3166-1 alpha-2 code"@en ;
  rdfs:comment "An ISO 3166-1 alpha-2 code that designates the country a biobank is located in."@en ;
  rdfs:subClassOf obo:OMIABIS_0000004 .

obo:IAO_0000318 a rdfs:Class ;
  rdfs:label "results section"@en ;
  rdfs:comment "A part of a publication about an investigation that is about a study design execution"@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:PATO_0000125 a rdfs:Class ;
  rdfs:label "mass" ;
  rdfs:comment "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." ;
  rdfs:subClassOf obo:BFO_0000019 .

obo:NGBO_6000201 a rdfs:Class ;
  rdfs:label "whole transcriptome sequence data"@en ;
  rdfs:comment "RNA sequence data which represent the complete complement of transcripts in a sample, at a given time"@en ;
  rdfs:subClassOf obo:OBIws_0000192 .

obo:ICO_0000127 a rdfs:Class ;
  rdfs:label "planned duration of study subject participation" ;
  rdfs:comment "a participation time that is the total length of time of subject's participation in a research study; from the time of enrollment to the completion of follow-up." ;
  rdfs:subClassOf obo:ICO_0000088 .

obo:CL_0009004 a rdfs:Class ;
  rdfs:label "retinal cell" ;
  rdfs:comment "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:NGBO_6000302 a rdfs:Class ;
  rdfs:label "clinical variant interpretation"@en ;
  rdfs:comment "A data item representing a variant’s significance in relation to a disease or phenotype." ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0001962 a rdfs:Class ;
  rdfs:label "target gene specification"@en ;
  rdfs:comment "is a directive information specifying a coding genomic region which is the focus of a planned process such as an assay, for instance in a environmental gene survey"@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0001891 a rdfs:Class ;
  rdfs:label "sequencing facility organization"@en ;
  rdfs:comment "An organization that provides sequence determination service" ;
  rdfs:subClassOf obo:OBI_0002198 .

obo:OBI_0002021 a rdfs:Class ;
  rdfs:label "NextSeq 500" ;
  rdfs:comment "A DNA sequencer which is a desktop sequencer ideal for smaller-scale studies manufactured by the Illumina corporation. It supports sequencing of single, long or short insert paired end clone libraries relying on sequencing by synthesis technology." ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:OBI_0600047 a rdfs:Class ;
  rdfs:label "sequencing assay" ;
  rdfs:comment "An assay the uses chemical or biochemical means to infer the sequence of a biomaterial" ;
  rdfs:subClassOf obo:NGBO_6000353 , obo:OBI_0000094 .

obo:OBIB_0000599 a rdfs:Class ;
  rdfs:label "clinical history of idiopathic heart disease" ;
  rdfs:comment "A clinical history in which there is a history of idiopathic heart disease." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:ICO_0000146 a rdfs:Class ;
  rdfs:label "eligibility of candidate participation"@en ;
  rdfs:comment "A realizable entity that represents the eligibility of a candidate according to a study protocol." ;
  rdfs:subClassOf obo:BFO_0000017 .

obo:CL_0000962 a rdfs:Class ;
  rdfs:label "Bm2 B cell" ;
  rdfs:subClassOf obo:CL_0000843 .

obo:CL_0002121 a rdfs:Class ;
  rdfs:label "CD24-negative CD38-negative IgG-negative class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0002118 .

obo:CL_0000837 a rdfs:Class ;
  rdfs:label "hematopoietic multipotent progenitor cell" ;
  rdfs:comment "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000233 a rdfs:Class ;
  rdfs:label "platelet" ;
  rdfs:comment "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." ;
  rdfs:subClassOf obo:CL_0000763 , <http://www.ebi.ac.uk/efo/EFO_0002534> .

obo:CL_0002002 a rdfs:Class ;
  rdfs:label "Kit-positive granulocyte monocyte progenitor" ;
  rdfs:subClassOf obo:CL_0000557 .

obo:CL_0000890 a rdfs:Class ;
  rdfs:label "alternatively activated macrophage" ;
  rdfs:subClassOf obo:CL_0000861 .

obo:CL_0002342 a rdfs:Class ;
  rdfs:label "circulating endothelial cell" ;
  rdfs:comment "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." ;
  rdfs:subClassOf obo:CL_0000115 .

obo:OBI_0002376 a rdfs:Class ;
  rdfs:label "father clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male parent." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OGMS_0000045 a rdfs:Class ;
  rdfs:label "disorder" ;
  rdfs:comment "A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:CL_0000384 a rdfs:Class ;
  rdfs:label "ligament cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0200178 a rdfs:Class ;
  rdfs:label "class discovery objective"@en ;
  rdfs:comment "A class discovery objective (sometimes called unsupervised classification) is a data transformation objective where the aim is to organize input data  (typically vectors of attributes) into classes, where the number of classes and their specifications are not known a priori. Depending on usage, the class assignment can be definite or probabilistic."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0000352 a rdfs:Class ;
  rdfs:label "epiblast cell" ;
  rdfs:comment "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." ;
  rdfs:subClassOf obo:CL_0002322 .

obo:IAO_0020015 a rdfs:Class ;
  rdfs:label "personal name"@en ;
  rdfs:comment "A personal name is a proper name identifying an individual person."@en ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:CL_0000612 a rdfs:Class ;
  rdfs:label "eosinophilic myelocyte" ;
  rdfs:subClassOf obo:CL_0000772 , obo:CL_0002193 .

obo:NGBO_0000058 a rdfs:Class ;
  rdfs:label "PM1 criteria"@en ;
  rdfs:comment """Located in a mutational hot spot and/or critical and well-established
functional domain (e.g. active site of an enzyme) without benign variation""" ;
  rdfs:subClassOf obo:NGBO_0000065 .

obo:OBIB_0000546 a rdfs:Class ;
  rdfs:label "clinical history of high unexplained fever" ;
  rdfs:comment "A clinical history in which there is a history of a high unexplained fever ." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0000101 a rdfs:Class ;
  rdfs:label "measured expression level"@en ;
  rdfs:comment "A measurement datum that is the outcome of the quantification of an assay for the activity of a gene, or the number of RNA transcripts."@en ;
  rdfs:subClassOf obo:IAO_0000109 .

obo:NGBO_6000190 a rdfs:Class ;
  rdfs:label "microRNA expression data"@en ;
  rdfs:comment "A measured expression level measurement datum which refers to represent small non-coding RNAs of 19-24 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development." ;
  rdfs:subClassOf obo:OBI_0000101 .

obo:OBI_0302908 a rdfs:Class ;
  rdfs:label "document editing"@en ;
  rdfs:comment "is a planned process with specified input original document and specified output edited document"@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:PATO_0000146 a rdfs:Class ;
  rdfs:label "temperature" ;
  rdfs:comment "A physical quality of the thermal energy of a system." ;
  rdfs:subClassOf obo:PATO_0001018 , obo:PATO_0001237 .

obo:OBI_0002113 a rdfs:Class ;
  rdfs:label "bromouridine labeling and sequencing assay" ;
  rdfs:comment "An RNA-seq assay to identify spans of nascent transcription in the genome through isolation of recent bromouridine (Bru) labelled RNAs." ;
  rdfs:subClassOf obo:OBI_0001271 .

obo:BFO_0000018 a rdfs:Class ;
  rdfs:label "zero-dimensional spatial region"@en ;
  rdfs:subClassOf obo:BFO_0000006 .

obo:OBI_0000518 a rdfs:Class ;
  rdfs:label "trap column"@en ;
  rdfs:comment "A trap column is a chromatography column which is used prior to a, e.g. mass spectrometry, separation to clean up or concentrate controlled amounts of samples prior to elution to a detector."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:IAO_0000065 a rdfs:Class ;
  rdfs:label "software interpreter"@en ;
  rdfs:comment "A software interpreter is a software application that executes some specified input software. "@en ;
  rdfs:subClassOf obo:IAO_0000064 .

obo:OBI_0000433 a rdfs:Class ;
  rdfs:label "DNA sequence feature detection assay" ;
  rdfs:comment "An assay with the objective to determine a sequence feature of DNA" ;
  rdfs:subClassOf obo:OBI_0200187 .

obo:CL_0000779 a rdfs:Class ;
  rdfs:label "multinuclear osteoclast" ;
  rdfs:subClassOf obo:CL_0000092 .

obo:CL_0002529 a rdfs:Class ;
  rdfs:label "CD1a-positive dermal dendritic cell" ;
  rdfs:subClassOf obo:CL_0001006 .

obo:OBI_0002517 a rdfs:Class ;
  rdfs:label "hair specimen" ;
  rdfs:comment "A specimen that is derived from hair." ;
  rdfs:subClassOf obo:OBI_0001479 .

<http://www.ebi.ac.uk/efo/EFO_0004905> a rdfs:Class ;
  rdfs:label "induced pluripotent stem cell"@en ;
  rdfs:comment "Induced pluripotent stem cells (iPS cells or iPSCs) are a type of pluripotent stem cell artificially derived from a non-pluripotent cell. Various methods exist to revert cells to pluripotency such as reprogramming mediated through a mature metaphase II oocyte as in somatic cell nuclear transfer." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0002958> , obo:CL_0002248 .

obo:OBI_0002383 a rdfs:Class ;
  rdfs:label "nephew clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a male child of a sibling." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:CL_0000002 a rdfs:Class ;
  rdfs:label "immortal cell line cell" ;
  rdfs:comment "A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBIB_0000419 a rdfs:Class ;
  rdfs:label "name of performer of gross evaluation of resected tissue specimen" ;
  rdfs:comment "A personal name that designates the person who performed the gross evaluation of a resected tissue specimen." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0100051 a rdfs:Class ;
  rdfs:label "specimen"@en ;
  rdfs:comment "A material entity that has the specimen role."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000186 a rdfs:Class ;
  rdfs:label "protocol optimization objective"@en ;
  rdfs:comment "Protocol_optimization is a protocol_testing_objective role describing a study designed to identify the best protocol.  This may be carried out by comparing different protocols or by modifying the parameters used within a single protocol."@en ;
  rdfs:subClassOf obo:OBI_0000096 .

obo:OBIB_0000545 a rdfs:Class ;
  rdfs:label "clinical history of open wounds" ;
  rdfs:comment "A clinical history in which there is a history of open wounds." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0001881 a rdfs:Class ;
  rdfs:label "organization of Bioinformatics Resource Center contact person"@en ;
  rdfs:comment "An organization that is the affiliation of the person who is contact representative of a Bioinformatics Resource Center" ;
  rdfs:subClassOf obo:OBI_0000245 .

obo:NGBO_6000364 a rdfs:Class ;
  rdfs:label "allele specific PCR protocol"@en ;
  rdfs:comment "A protocol which describes the process of Allele-specific polymerase chain reaction (PCR)"@en ;
  rdfs:subClassOf obo:OBI_0000272 .

obo:BFO_0000140 a rdfs:Class ;
  rdfs:label "continuant fiat boundary"@en ;
  rdfs:comment "b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])"@en ;
  rdfs:subClassOf obo:BFO_0000141 .

obo:CL_0000943 a rdfs:Class ;
  rdfs:label "Be1 Cell" ;
  rdfs:subClassOf obo:CL_0000968 .

obo:OBIB_0000577 a rdfs:Class ;
  rdfs:label "clinical history of night sweats" ;
  rdfs:comment "A clinical history in which there is a history of night sweats." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000353 a rdfs:Class ;
  rdfs:label "omics data generation assay"@en ;
  rdfs:comment "An assay which generate OMICS data through a wet bench process such as sequencing techniques." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:CL_0000818 a rdfs:Class ;
  rdfs:label "transitional stage B cell" ;
  rdfs:subClassOf obo:CL_0000236 .

obo:OBI_0000456 a rdfs:Class ;
  rdfs:label "material transformation objective"@en ;
  rdfs:comment "an objective specifiction that creates an specific output object from input materials."@en ;
  rdfs:subClassOf obo:IAO_0000005 .

obo:OBIB_0000568 a rdfs:Class ;
  rdfs:label "clinical history of exposure to rabies" ;
  rdfs:comment "A clinical history in which there is a history of an animal bite in recent past, from an animal suspected to have rabies." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:NGBO_6000140 a rdfs:Class ;
  rdfs:label "axt file format"@en ;
  rdfs:comment "A file format which represent alignment files are produced from Blastz, an alignment tool available from Webb Miller's lab at Penn State University. The axtNet and axtChain alignments are produced by processing the alignment files with additional utilities written by Jim Kent at UCSC" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:NGBO_6000012 a rdfs:Class ;
  rdfs:label "2bit format"@en ;
  rdfs:comment "A file format which represent a binary file format designed for storing a genome consists of multiple chromosomal sequences" ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:NGBO_6000021 a rdfs:Class ;
  rdfs:label "BAM format"@en ;
  rdfs:comment "A file format which represent binary format for storing sequence data." ;
  rdfs:subClassOf obo:NGBO_6000003 .

obo:OBI_0000372 a rdfs:Class ;
  rdfs:label "material separation function"@en ;
  rdfs:comment "A material separation function is a function that increases the resolution between two or more material entities. The  to distinction between the entities is usually based on some associated physical quality."@en ;
  rdfs:subClassOf obo:BFO_0000034 .

obo:OBIB_0000512 a rdfs:Class ;
  rdfs:label "lifelong non-smoker history" ;
  rdfs:comment "A Smoking History in which there was no or an insignificant level of smoking." ;
  rdfs:subClassOf obo:NCIT_C29719 .

obo:OBIB_0000402 a rdfs:Class ;
  rdfs:label "confirmation of histologic type of FFPE H&E tumor slide" ;
  rdfs:comment "An information content entity that is an indicator of whether the local pathology review of a formalin-fixed paraffin-embedded (FFPE) hematoxylin and eosin (H&E)-stained tumor tissue slide confirmed the histological type." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:CL_0000007 a rdfs:Class ;
  rdfs:label "early embryonic cell" ;
  rdfs:comment "A cell found in the embryo before the formation of all the gem layers is complete." ;
  rdfs:subClassOf obo:CL_0002321 .

<http://semanticscience.org/resource/SIO_000653> a rdfs:Class ;
  rdfs:label "version label"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000115> .

obo:NGBO_6000157 a rdfs:Class ;
  rdfs:label "specimen with potentially infectious materials"@en ;
  rdfs:comment "A specimen that derives from an organism and might contain infectious materials." ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:NGBO_6000148 a rdfs:Class ;
  rdfs:label "paraffin embedding and Fixation quality check report"@en ;
  rdfs:comment "required quality check list for the procedure of paraffin embedding and/or fixation." ;
  rdfs:subClassOf obo:NGBO_6000257 .

obo:CL_0000844 a rdfs:Class ;
  rdfs:label "germinal center B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

obo:CL_0000216 a rdfs:Class ;
  rdfs:label "Sertoli cell" ;
  rdfs:comment "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." ;
  rdfs:subClassOf obo:CL_0000151 .

obo:OMIABIS_0000093 a rdfs:Class ;
  rdfs:label "biobank contact role"@en ;
  rdfs:comment "A contact role borne by a member of a biobank organization and realized by serving as the contact for one of its biobanks."@en ;
  rdfs:subClassOf obo:OMIABIS_0000012 .

obo:IAO_0000620 a rdfs:Class ;
  rdfs:label "ethical approval section"@en ;
  rdfs:comment "A part of a document about the governance body responsible for approving the work discussed in a document on an ethical basis."@en ;
  rdfs:subClassOf obo:IAO_0000314 .

obo:NGBO_6000417 a rdfs:Class ;
  rdfs:label "software run identifier"@en ;
  rdfs:comment "An identifier which denotes the bioinformatics analysis ID." ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000115> .

obo:ICO_0000001 a rdfs:Class ;
  rdfs:label "informed consent form" ;
  rdfs:comment "A document that explains all relevant study information to assist a human subject in understanding the expectations and requirements of participation in a research study. This form document is presented to and signed by the study subject. "@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0002532 a rdfs:Class ;
  rdfs:label "esophagus mucosa specimen" ;
  rdfs:comment "A specimen that is derived from esophagus mucosa." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OBI_0002379 a rdfs:Class ;
  rdfs:label "son clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a person's male child." ;
  rdfs:subClassOf obo:OBI_0002372 .

obo:OBI_0600005 a rdfs:Class ;
  rdfs:label "collecting specimen from organism"@en ;
  rdfs:comment "a process with the objective to obtain a material entity that was part of an organism for potential future use in an investigation"@en ;
  rdfs:subClassOf obo:OBI_0000659 .

obo:OBI_0002547 a rdfs:Class ;
  rdfs:label "minor salivary gland specimen" ;
  rdfs:comment "A specimen that is derived from minor salivary gland." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:OMIABIS_0000012 a rdfs:Class ;
  rdfs:label "contact role"@en ;
  rdfs:comment "A role borne by a human being that is part of an group of individuals and acts as contact person for the group. This role gets realized by the bearer being a participant in a contacting process."@en ;
  rdfs:subClassOf obo:OMRSE_00000024 .

obo:CL_0000510 a rdfs:Class ;
  rdfs:label "paneth cell"@en ;
  rdfs:comment "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." ;
  rdfs:subClassOf obo:CL_0000066 , obo:CL_0000151 , <http://www.ebi.ac.uk/efo/EFO_0000324> .

<http://semanticscience.org/resource/SIO_000119> a rdfs:Class ;
  rdfs:label "brand name"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000116> .

obo:OBIB_0000321 a rdfs:Class ;
  rdfs:label "fresh microtome blade" ;
  rdfs:comment "A microtome blade age that indicates that the microtome blade is as new as possible." ;
  rdfs:subClassOf obo:OBIB_0000320 .

obo:CL_0000362 a rdfs:Class ;
  rdfs:label "epidermal cell" ;
  rdfs:comment "An epithelial cell of the integument (the outer layer of an organism)." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:OBI_0002581 a rdfs:Class ;
  rdfs:label "merged aligned sequence data" ;
  rdfs:comment "The results of a data transformation of sequence data in which files containing aligned sequence data are merged together" ;
  rdfs:subClassOf obo:OBI_0000973 .

obo:CL_0000096 a rdfs:Class ;
  rdfs:label "mature neutrophil" ;
  rdfs:subClassOf obo:CL_0000775 .

obo:OBI_0002542 a rdfs:Class ;
  rdfs:label "aorta specimen" ;
  rdfs:comment "A specimen that is derived from aorta." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:CL_0000066 a rdfs:Class ;
  rdfs:label "epithelial cell" ;
  rdfs:comment "Cell that line the inner and outer surfaces of the body by forming cellular layers (epithelium) or masses (MSH)." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002471 a rdfs:Class ;
  rdfs:label "MHC-II-negative non-classical monocyte" ;
  rdfs:subClassOf obo:CL_0002058 .

obo:OBI_0001494 a rdfs:Class ;
  rdfs:label "linear amplification"@en ;
  rdfs:comment "An enzymatic amplification which amplifies nucleic acid sequence by making many copies off the same template." ;
  rdfs:subClassOf obo:OBI_0600058 .

obo:OBIB_0000029 a rdfs:Class ;
  rdfs:label "medication material"@en ;
  rdfs:comment "A material entity that is bearer of a medication role." ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0002372 a rdfs:Class ;
  rdfs:label "family clinical history of cancer" ;
  rdfs:comment "A clinical history in which there is a diagnosis of cancer in a blood relative." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OGMS_0000015 a rdfs:Class ;
  rdfs:label "clinical history" ;
  rdfs:comment "A series of statements representing health-relevant qualities of a patient and of a patient's family."@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_001196> .

obo:OBI_0000888 a rdfs:Class ;
  rdfs:label "nuclear RNA extraction" ;
  rdfs:comment "A RNA extraction process in which the desired output material is RNA in the nucleus." ;
  rdfs:subClassOf obo:OBI_0666666 .

obo:OBIB_0000563 a rdfs:Class ;
  rdfs:label "clinical history of long term steroid use" ;
  rdfs:comment "A clinical history in which there is a history of long term steroid use." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000136 a rdfs:Class ;
  rdfs:label "fat cell" ;
  rdfs:comment "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of tryglycerides." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

<http://semanticscience.org/resource/SIO_000120> a rdfs:Class ;
  rdfs:label "scientific name"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000116> .

obo:CL_0000670 a rdfs:Class ;
  rdfs:label "primordial germ cell" ;
  rdfs:comment "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." ;
  rdfs:subClassOf obo:CL_0000586 .

obo:OBI_0000257 a rdfs:Class ;
  rdfs:label "DNA extraction"@en ;
  rdfs:comment "A DNA extraction is a nucleic acid extraction where the desired output material is DNA."@en ;
  rdfs:subClassOf obo:OBI_0666667 .

obo:CL_0000040 a rdfs:Class ;
  rdfs:label "monoblast" ;
  rdfs:subClassOf obo:CL_0002194 .

obo:OBI_0001869 a rdfs:Class ;
  rdfs:label "Illumina BeadChip"@en ;
  rdfs:comment "An array that consists of 3-micron silica beads that self assemble in microwells on either of two materials: fiber optic bundles or planar silica slides." ;
  rdfs:subClassOf obo:OBI_0001865 .

obo:NGBO_6000216 a rdfs:Class ;
  rdfs:label "global sequence alignment"@en ;
  rdfs:comment "A sequence alignment which align every residue in every sequence"@en ;
  rdfs:subClassOf obo:OBI_0002567 .

obo:CL_0000351 a rdfs:Class ;
  rdfs:label "trophoblast cell" ;
  rdfs:comment "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." ;
  rdfs:subClassOf obo:CL_0000349 .

obo:OBI_0200179 a rdfs:Class ;
  rdfs:label "class prediction objective"@en ;
  rdfs:comment """A class prediction objective (sometimes called supervised classification) is a data transformation objective where the aim is to create a predictor from training data through a machine learning technique. The training data consist of pairs of objects (typically vectors of attributes) and
class labels for these objects. The resulting predictor can be used to attach class labels to any valid novel input object. Depending on usage, the prediction can be definite or probabilistic. A classification is learned from the training data and can then be tested on test data."""@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0000965 a rdfs:Class ;
  rdfs:label "Bm3 B cell" ;
  rdfs:subClassOf obo:CL_0000844 .

obo:CL_0000077 a rdfs:Class ;
  rdfs:label "mesothelial cell" ;
  rdfs:comment "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." ;
  rdfs:subClassOf obo:CL_0000066 .

obo:OBI_0002570 a rdfs:Class ;
  rdfs:label "nCounter Mouse miRNA Expression array" ;
  rdfs:comment "A mouse array which is manufacutred by NanoString Technologies. Built upon color-coded molecular barcodes technology, the array profiles miRNA with increased specificity and sensitivty than microarrays." ;
  rdfs:subClassOf obo:OBI_0001865 .

obo:OBI_0000533 a rdfs:Class ;
  rdfs:label "affinity column"@en ;
  rdfs:comment "An affinity column is a chromatography column that is used in affinity chromatography. Differences in the affinity of molecules to be separated to a stationary phase are used for discriminate retention."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0000652 a rdfs:Class ;
  rdfs:label "material combination" ;
  rdfs:comment "is a material processing with the objective to combine two or more material entities as input into a single material entity as output." ;
  rdfs:subClassOf obo:OBI_0000094 .

obo:NGBO_6000288 a rdfs:Class ;
  rdfs:label "storage unit identifier"@en ;
  rdfs:comment "Each freezer, refrigerator, room temperature stor- age cabinet, or other unit appropriate to the collec- tions should have a unique identifier." ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000115> .

obo:OBIB_0000579 a rdfs:Class ;
  rdfs:label "clinical history of unexplained lymphadenopathy" ;
  rdfs:comment "A clinical history in which there is a history of unexplained lymphadenopathy of a specific duration." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0001870 a rdfs:Class ;
  rdfs:label "Illumina methylation BeadChip"@en ;
  rdfs:comment "A BeadChip made for an analyte assay that generates information about DNA methylation." ;
  rdfs:subClassOf obo:OBI_0001869 .

obo:CL_0000521 a rdfs:Class ;
  rdfs:label "fungal cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0000967 a rdfs:Class ;
  rdfs:label "Bm5 B cell" ;
  rdfs:subClassOf obo:CL_0000787 .

<http://www.ebi.ac.uk/efo/EFO_0002439> a rdfs:Class ;
  rdfs:label "mesophyll cell" ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0001235 a rdfs:Class ;
  rdfs:label "transcription profiling by tiling array assay" ;
  rdfs:comment "A transcription profiling by array assay that uses a tiling path array." ;
  rdfs:subClassOf obo:OBI_0001463 .

obo:OBI_0600016 a rdfs:Class ;
  rdfs:label "pooling specimens"@en ;
  rdfs:comment "physical combination of several instances of like material"@en ;
  rdfs:subClassOf obo:OBI_0000652 .

obo:CL_0000833 a rdfs:Class ;
  rdfs:label "eosinophilic promyelocyte" ;
  rdfs:subClassOf obo:CL_0000836 .

obo:UBERON_0000016 a rdfs:Class ;
  rdfs:label "endocrine pancreas" ;
  rdfs:comment "The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin[GO]." ;
  rdfs:subClassOf obo:CL_0000151 .

<http://www.ebi.ac.uk/efo/EFO_0005495> a rdfs:Class ;
  rdfs:label "NSM" ;
  rdfs:comment "Neuron class of two pharyngeal neurosecretory-motor neurons." ;
  rdfs:subClassOf obo:CL_0000165 .

obo:OBI_0200078 a rdfs:Class ;
  rdfs:label "descriptive statistical calculation objective"@en ;
  rdfs:comment "A descriptive statistical calculation objective is a data transformation objective which concerns any calculation intended to describe a feature of a data set, for example, its center or its variability."@en ;
  rdfs:subClassOf obo:OBI_0200166 .

obo:CL_0000622 a rdfs:Class ;
  rdfs:label "acinar cell" ;
  rdfs:comment "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." ;
  rdfs:subClassOf obo:CL_0000151 .

<http://semanticscience.org/resource/SIO_000675> a rdfs:Class ;
  rdfs:label "unique identifier"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000115> .

<http://semanticscience.org/resource/SIO_000674> a rdf:Property ;
  rdfs:label "is unique identifier for"@en ;
  rdfs:domain <http://semanticscience.org/resource/SIO_000675> ;
  rdfs:range <https://w3id.org/linkml/Any> ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000672> .

obo:IAO_0000594 a rdfs:Class ;
  rdfs:label "software application"@en ;
  rdfs:comment "A software application is software that can be directly executed by some processing unit."@en ;
  rdfs:subClassOf obo:IAO_0000010 .

obo:BFO_0000031 a rdfs:Class ;
  rdfs:label "generically dependent continuant"@en ;
  rdfs:comment "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en ;
  rdfs:subClassOf obo:BFO_0000002 .

obo:OBIB_0000315 a rdfs:Class ;
  rdfs:label "adherence to FFPE tissue block storage SOP" ;
  rdfs:comment "An information content entity that indicates whether the FFPE tissue block storage SOP was followed." ;
  rdfs:subClassOf obo:NGBO_6000148 .

<http://semanticscience.org/resource/SIO_000942> a rdfs:Class ;
  rdfs:label "numeric label"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000179> .

<https://w3id.org/linkml/Any> a rdfs:Class ;
  rdfs:comment "An unconstrained type or object" .

obo:CL_0000869 a rdfs:Class ;
  rdfs:label "tonsillar macrophage" ;
  rdfs:subClassOf obo:CL_0000884 .

obo:CL_0000611 a rdfs:Class ;
  rdfs:label "eosinophil progenitor cell" ;
  rdfs:subClassOf obo:CL_0002191 .

obo:CL_0002247 a rdfs:Class ;
  rdfs:label "pleural macrophage" ;
  rdfs:subClassOf obo:CL_0000864 .

obo:OBIB_0000295 a rdfs:Class ;
  rdfs:label "FFPE dehydration process duration" ;
  rdfs:comment "A time measurement datum that is the result of measuring the duration of the dehydration process in the formalin-fixed paraffin-embedded (FFPE) process." ;
  rdfs:subClassOf obo:IAO_0000416 .

obo:OBI_0001472 a rdfs:Class ;
  rdfs:label "specimen with known storage state"@en ;
  rdfs:comment "A specimen for which it is known whether it has been subjected to storage of a specified type." ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:CL_0000995 a rdfs:Class ;
  rdfs:label "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor" ;
  rdfs:subClassOf obo:CL_0002032 .

obo:IAO_0000005 a rdfs:Class ;
  rdfs:label "objective specification"@en ;
  rdfs:comment "A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved."@en ;
  rdfs:subClassOf obo:IAO_0000033 .

obo:CL_0002028 a rdfs:Class ;
  rdfs:label "basophil mast progenitor cell" ;
  rdfs:subClassOf obo:CL_0000839 .

obo:OBI_0002390 a rdfs:Class ;
  rdfs:label "exposure to second hand smoke" ;
  rdfs:comment "A clinical history in which there has been second hand exposure to tobacco smoking. " ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000182 a rdfs:Class ;
  rdfs:label "hepatocyte" ;
  rdfs:comment "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:CL_0002119 a rdfs:Class ;
  rdfs:label "CD38-positive IgG-negative class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0002117 .

obo:OBI_0200000 a rdfs:Class ;
  rdfs:label "data transformation"@en ;
  rdfs:comment "A planned process that produces output data from input data."@en ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:NGBO_6000238 a rdfs:Class ;
  rdfs:label "DNA extraction assay kit"@en ;
  rdfs:comment "An assay kit used for the technique of isolating DNA in a biological sample" ;
  rdfs:subClassOf obo:NGBO_6000236 .

obo:OBI_0000811 a rdfs:Class ;
  rdfs:label "primary structure of DNA macromolecule" ;
  rdfs:comment "a quality of a DNA molecule that inheres in its bearer due to the order of its DNA nucleotide residues." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:OBI_0000791 a rdfs:Class ;
  rdfs:label "multiple testing correction objective" ;
  rdfs:comment "A multiple testing correction objectives is a data transformation objective where the aim is to correct for a set of statistical inferences considered simultaneously" ;
  rdfs:subClassOf obo:OBI_0200186 .

obo:OBIB_0000232 a rdfs:Class ;
  rdfs:label "name of person performing blood draw" ;
  rdfs:comment "A personal name that designates the person who performed the collection of a blood specimen." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001107 a rdfs:Class ;
  rdfs:label "tissue embedding station" ;
  rdfs:comment "A device that is used to perform paraffin embedding of tissue specimens." ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:BFO_0000147 a rdfs:Class ;
  rdfs:label "zero-dimensional continuant fiat boundary"@en ;
  rdfs:subClassOf obo:BFO_0000140 .

obo:OBI_0001901 a rdfs:Class ;
  rdfs:label "specimen identifier assigned by sequencing facility"@en ;
  rdfs:comment "A specimen identifier which is assigned by a sequencing facility" ;
  rdfs:subClassOf obo:NGBO_6000161 , obo:OBI_0001616 .

obo:CL_0000165 a rdfs:Class ;
  rdfs:label "neuroendocrine cell" ;
  rdfs:comment "A neuron that has the specialized function to produce and secrete hormones, and that constitutes, in whole or in part, an endocrine organ or system." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0000324> .

obo:OBI_0001483 a rdfs:Class ;
  rdfs:label "cell collecting"@en ;
  rdfs:comment "A planned process that collects cells from culture." ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:NGBO_6000476 a rdfs:Class ;
  rdfs:label "oligonucleotide probe"@en ;
  rdfs:comment "A region of short stretches of single-stranded DNA or RNA used to detect the presence of complementary nucleic acid sequences (target sequences) by hybridization." ;
  rdfs:subClassOf obo:SO_0000001 .

obo:OBIB_0000508 a rdfs:Class ;
  rdfs:label "current non-drinker of alcohol" ;
  rdfs:comment "An Alcohol Use History in which there was alcohol consumption in the past but is currently a non-drinker of alcohol." ;
  rdfs:subClassOf obo:NCIT_C81229 .

obo:OBI_0000659 a rdfs:Class ;
  rdfs:label "specimen collection process" ;
  rdfs:comment "A planned process with the objective of collecting a specimen." ;
  rdfs:subClassOf obo:OBI_0000011 .

obo:CL_0000984 a rdfs:Class ;
  rdfs:label "IgA plasmablast" ;
  rdfs:subClassOf obo:CL_0000980 .

obo:NGBO_6000299 a rdfs:Class ;
  rdfs:label "specimen culling"@en ;
  rdfs:comment "A specimen culling is the process of reviewing and eliminating specimens in a collection or an entire collection either by destruction or transfer to a new custodian" ;
  rdfs:subClassOf obo:OBI_0000011 .

<http://semanticscience.org/resource/SIO_000183> a rdfs:Class ;
  rdfs:label "personal name"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000116> .

obo:BFO_0000144 a rdfs:Class ;
  rdfs:label "process profile"@en ;
  rdfs:comment "b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])"@en ;
  rdfs:subClassOf obo:BFO_0000015 .

obo:OBIB_0000588 a rdfs:Class ;
  rdfs:label "clinical history of West Nile Virus exposure" ;
  rdfs:comment "A clinical history in which there is a history of contact with a human or animal who has West Nile Virus (WNV)." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:CL_0000772 a rdfs:Class ;
  rdfs:label "immature eosinophil" ;
  rdfs:subClassOf obo:CL_0000771 .

obo:CL_0002017 a rdfs:Class ;
  rdfs:label "Kit-negative, Ly-76 high orthochromatophilic erythroblasts" ;
  rdfs:subClassOf obo:CL_0000552 .

<http://semanticscience.org/resource/SIO_000179> a rdfs:Class ;
  rdfs:label "label"@en ;
  rdfs:subClassOf <http://semanticscience.org/resource/SIO_000651> .

obo:CL_0002102 a rdfs:Class ;
  rdfs:label "CD38-negative naive B cell" ;
  rdfs:subClassOf obo:CL_0000788 .

obo:OBIB_0000304 a rdfs:Class ;
  rdfs:label "adherence to paraffin impregnation method in FFPE tissue processing SOP" ;
  rdfs:comment "An information content entity that indicates whether the paraffin impregnation method followed that prescribed in the FFPE tissue processing SOP." ;
  rdfs:subClassOf obo:NGBO_6000148 .

obo:OBI_0000679 a rdfs:Class ;
  rdfs:label "average value"@en ;
  rdfs:comment "A  data item that is produced as the output of an averaging data transformation and represents the average value of the input data."@en ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0002536 a rdfs:Class ;
  rdfs:label "cerebral cortex specimen" ;
  rdfs:comment "A specimen that is derived from cerebral cortex." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:IAO_0020000 a rdfs:Class ;
  rdfs:label "proper name"@en ;
  rdfs:comment "A proper name is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity. "@en ;
  rdfs:subClassOf obo:BFO_0000020 .

obo:OMIABIS_0000004 a rdfs:Class ;
  rdfs:label "ISO 3166-1 alpha-2 code"@en ;
  rdfs:comment "An identifier that consists of two letters, is part of the ISO 3166-1, and designates countries, dependent territories, and special areas of geographical interest."@en ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:OBI_0002524 a rdfs:Class ;
  rdfs:label "urinary bladder specimen" ;
  rdfs:comment "A specimen that is derived from urinary bladder." ;
  rdfs:subClassOf obo:OBI_0001479 .

obo:NGBO_6000409 a rdfs:Class ;
  rdfs:label "information about software"@en ;
  rdfs:comment "Information content entity about bioinformatics software" ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0001117 a rdfs:Class ;
  rdfs:label "DNA extraction/purification instrument" ;
  rdfs:comment "A device that is used to isolate and collect DNA for subsequent molecular analysis." ;
  rdfs:subClassOf obo:OBI_0001114 .

obo:OMIABIS_0000038 a rdfs:Class ;
  rdfs:label "name of sample collection responsible or principal investigator"@en ;
  rdfs:comment "A personal name that designates the human being responsible for a sample collection or the human being being the principal investigator in a study."@en ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0002076 a rdfs:Class ;
  rdfs:label "collection of specimens"@en ;
  rdfs:comment "A material entity that has two or more specimens as its parts."@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:RO_0002351 a rdf:Property ;
  rdfs:label "has member"@en ;
  rdfs:comment "has member is a mereological relation between a collection and an item." ;
  rdfs:range obo:OBI_0100051 .

obo:OBIB_0000243 a rdfs:Class ;
  rdfs:label "vacutainer specimen barcode" ;
  rdfs:comment "A specimen barcode that is associated with a vacutainer." ;
  rdfs:subClassOf obo:FLU_0001019 .

obo:GAZ_00000448 a rdfs:Class ;
  rdfs:label "geographic location" ;
  rdfs:comment "A reference to a place on the Earth, by its name or by its geographical location." ;
  rdfs:subClassOf obo:BFO_0000029 .

<http://semanticscience.org/resource/SIO_001041> a rdfs:Class ;
  rdfs:label "study design"@en ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:OBI_0000134 a rdfs:Class ;
  rdfs:label "hardware testing objective"@en ;
  rdfs:comment "Hardware_testing_objective is a methodology_testing_objective role describing a study designed to examine the effects of using different hardware, e.g. scanner."@en ;
  rdfs:subClassOf obo:OBI_0000208 .

obo:ICO_0000024 a rdfs:Class ;
  rdfs:label "partially filled informed consent form" ;
  rdfs:comment "an informed consent form that has been partically filled with required contents." ;
  rdfs:subClassOf obo:ICO_0000001 .

obo:CL_0000163 a rdfs:Class ;
  rdfs:label "endocrine cell" ;
  rdfs:comment "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." ;
  rdfs:subClassOf obo:CL_0000151 .

obo:CL_0001005 a rdfs:Class ;
  rdfs:label "mature CD8_alpha-positive CD11b-negative dendritic cell" ;
  rdfs:subClassOf obo:CL_0001000 .

obo:CL_0002056 a rdfs:Class ;
  rdfs:label "Fraction F mature B cell" ;
  rdfs:subClassOf obo:CL_0000785 .

<http://purl.obolibrary.org/obo/ngbo.owl/NGBO_6000284> a rdfs:Class ;
  rdfs:label "peripheral blood mononuclear cell isolation"@en ;
  rdfs:comment "A cell collecting process used to isolate PBMCs, including T cells, from whole blood using density gradient centrifugation (e.g., Ficoll-Paque)." ;
  rdfs:subClassOf obo:OBI_0001483 .

obo:CL_0000746 a rdfs:Class ;
  rdfs:label "cardiac muscle cell" ;
  rdfs:comment "A striated muscle cell found in the heart. They develop from cardiac myoblasts." ;
  rdfs:subClassOf obo:CL_0000187 .

obo:OBI_0001143 a rdfs:Class ;
  rdfs:label "labeled nucleic acid extract" ;
  rdfs:comment "a labeled specimen that is the output of a labeling process and has grain labeled nucleic acid for detection of the nucleic acid in future experiments." ;
  rdfs:subClassOf obo:OBI_0000924 .

obo:NCBITaxon_40674 a rdfs:Class ;
  rdfs:label "Mammalia" ;
  rdfs:subClassOf obo:NCBITaxon_32524 .

obo:NGBO_6000093 a rdfs:Class ;
  rdfs:label "data transfer agreement"@en ;
  rdfs:comment "A document information content entity established between organisations that governs the transfer of one or more data sets from the owner/provider to a third party" ;
  rdfs:subClassOf obo:IAO_0000310 .

obo:NGBO_6000161 a rdfs:Class ;
  rdfs:label "personally identifiable information"@en ;
  rdfs:comment "A data item infromation content entity that represent any data that could potentially identify a specific individual. Any information that can be used to distinguish one person from another and can be used for de-anonymizing anonymous data can be considered PII." ;
  rdfs:subClassOf obo:IAO_0000027 .

obo:OBI_0001865 a rdfs:Class ;
  rdfs:label "assay array"@en ;
  rdfs:comment "A device made to be used in an analyte assay for immobilization of substances that bind the analyte at regular spatial positions on a surface." ;
  rdfs:subClassOf obo:OBI_0000968 .

obo:CL_0002117 a rdfs:Class ;
  rdfs:label "IgG-negative class switched memory B cell" ;
  rdfs:subClassOf obo:CL_0000972 .

obo:CL_0002114 a rdfs:Class ;
  rdfs:label "CD38-positive unswitched memory B cell" ;
  rdfs:subClassOf obo:CL_0000970 .

obo:IAO_0000027 a rdfs:Class ;
  rdfs:label "data item"@en ;
  rdfs:comment "a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:CL_0000782 a rdfs:Class ;
  rdfs:label "myeloid dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:OBI_0002397 a rdfs:Class ;
  rdfs:label "gynecologic surgery history" ;
  rdfs:comment "A clinical history in which a woman has had gynecologic surgery in the past." ;
  rdfs:subClassOf obo:OGMS_0000015 .

obo:OBI_0002029 a rdfs:Class ;
  rdfs:label "serial analysis of gene expression assay" ;
  rdfs:comment "A transcription profiling assay that quantifies RNA through creating short signature tags of the messages and ligating them into a larger molecule than was sequenced." ;
  rdfs:subClassOf obo:OBI_0000424 .

obo:BFO_0000024 a rdfs:Class ;
  rdfs:label "fiat object"@en ;
  rdfs:subClassOf obo:BFO_0000040 .

obo:CL_0000559 a rdfs:Class ;
  rdfs:label "promonocyte" ;
  rdfs:subClassOf obo:CL_0002194 .

obo:OBIB_0000480 a rdfs:Class ;
  rdfs:label "identifier for legally authorized representative" ;
  rdfs:comment "An identifier that uniquely identifies a particular legally authorized representative in a research study." ;
  rdfs:subClassOf obo:IAO_0020000 .

obo:OBI_0001128 a rdfs:Class ;
  rdfs:label "micropipette" ;
  rdfs:comment "A microinjection device that is used to measure very small volumes of liquids." ;
  rdfs:subClassOf obo:OBI_0000832 .

obo:OBI_0302906 a rdfs:Class ;
  rdfs:label "DNA Subtraction"@en ;
  rdfs:comment "a material separation process by which repetitive genomic DNA is removed during the construction of cDNA library."@en ;
  rdfs:subClassOf obo:OBI_0600014 .

obo:OBI_0001616 a rdfs:Class ;
  rdfs:label "specimen identifier"@en ;
  rdfs:comment "A CRID symbol denotes a specimen and used to distinguish one specimen from another in an investigation."@en ;
  rdfs:subClassOf obo:IAO_0000577 , <http://semanticscience.org/resource/SIO_000115> .

obo:CL_0002507 a rdfs:Class ;
  rdfs:label "langerin-positive lymph node dendritic cell" ;
  rdfs:subClassOf obo:CL_0000990 .

obo:NCBITaxon_32524 a rdfs:Class ;
  rdfs:label "Amniota" ;
  rdfs:subClassOf obo:NCBITaxon_32523 .

obo:NGBO_6000406 a rdfs:Class ;
  rdfs:label "name of bioinformatics analysis executor"@en ;
  rdfs:comment "A personal name that designates the person who executed the bioinformatics analysis." ;
  rdfs:subClassOf obo:IAO_0020015 .

obo:OBI_0001064 a rdfs:Class ;
  rdfs:label "automatic tissue processor" ;
  rdfs:comment "A device for processing histological tissue having a tissue carrier basket suspended from a turntable overlying a plurality of beakers suspended from a carrier plate. The turntable is raised, indexed, and lowered by a suitable driving mechanism to move the tissue basket sequentially through the beakers. Timers can each be programmed to control the movement of the turntable to provide various different cycles for processing the tissue. Some of the beakers are received in individual thermal baths to heat and control the temperature of the substances received in the beakers for treating the tissue." ;
  rdfs:subClassOf obo:OBI_0000968 .

<http://www.ebi.ac.uk/efo/EFO_0002573> a rdfs:Class ;
  rdfs:label "small adipocyte" ;
  rdfs:subClassOf obo:CL_0000136 .

<http://www.ebi.ac.uk/efo/EFO_0000187> a rdfs:Class ;
  rdfs:label "Kaposi's sarcoma cell" ;
  rdfs:comment "A multicentric, malignant neoplastic vascular proliferation characterized by bluish-red cutaneous nodules, usually on the legs, toes, or feet, that slowly increase in size and number and spread to more proximal sites. The tumors have endothelium-lined channels and vascular spaces mixed with aggregates of spindle-shaped cells; they may remain confined to skin and subcutaneous tissue, but widespread visceral involvement may occur." ;
  rdfs:subClassOf <http://www.ebi.ac.uk/efo/EFO_0005934> .

obo:IAO_0000310 a rdfs:Class ;
  rdfs:label "document"@en ;
  rdfs:comment "A collection of information content entities intended to be understood together as a whole"@en ;
  rdfs:subClassOf obo:IAO_0000030 .

obo:NGBO_6000179 a rdfs:Class ;
  rdfs:label "alignment"@en ;
  rdfs:comment "A bioinformatics analysis data transformation which two or more things are positioned in a straight line or parallel to each other"@en ;
  rdfs:subClassOf obo:NGBO_6000122 .

obo:OBI_0000586 a rdfs:Class ;
  rdfs:label "plunger column"@en ;
  rdfs:comment "A plunger column is a chromatography column with adjustable heigth control. By means of an adjustable endpiece (plunger) the user can adjust the column length without disturbing the packed bed. Plunger columns can equalize volume changes and thus avoids dead volumes within the column."@en ;
  rdfs:subClassOf obo:OBI_0000038 .

obo:OBI_0000086 a rdfs:Class ;
  rdfs:label "reagent role"@en ;
  rdfs:comment "A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer."@en ;
  rdfs:subClassOf obo:BFO_0000023 .

obo:CL_0000822 a rdfs:Class ;
  rdfs:label "B-2 B cell" ;
  rdfs:comment "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." ;
  rdfs:subClassOf obo:CL_0000236 , obo:CL_0000785 .

obo:CL_0000838 a rdfs:Class ;
  rdfs:label "lymphoid lineage restricted progenitor cell" ;
  rdfs:subClassOf obo:CL_0002031 .

obo:NGBO_6000235 a rdfs:Class ;
  rdfs:label "sequence data quality validation"@en ;
  rdfs:comment "A data validating whech validate sequencing quality scores and measure the probability that a base is called incorrectly." ;
  rdfs:subClassOf obo:NGBO_6000232 .

obo:CL_0001013 a rdfs:Class ;
  rdfs:label "mature interstitial dendritic cell" ;
  rdfs:subClassOf obo:CL_0001007 .

obo:NGBO_6000150 a rdfs:Class ;
  rdfs:label "remnant specimen"@en ;
  rdfs:comment "a specimen which represent remaining portion of a specimen obtained for clinical purposes that is no longer needed for its original purpose and that would otherwise be discarded" ;
  rdfs:subClassOf obo:OBI_0100051 .

obo:OBI_0002129 a rdfs:Class ;
  rdfs:label "Illumina HiSeq X Ten"@en ;
  rdfs:comment "A DNA sequencer that consists of a set of 10 HiSeq X Sequencing Systems."@en ;
  rdfs:subClassOf obo:OBI_0400103 .

obo:BFO_0000060 a rdf:Property ;
  rdfs:label "preceded by" ;
  rdfs:comment "Please note that, as stated on one of the RO documentation pages (https://code.google.com/p/obo-relations/wiki/ROAndBFO), some of the relations RO makes use are either uncontroversial (non-temporalized) parts of BFO2, or will be incorporated in the future. In the case of BFO_0000063, it is not currently in BFO2, but may be in the future. The RO ontologists assume this is the transitive form. For a full definition, refer to the inverse of this property, BFO_0000060. (Allyson Lister)" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:BFO_0000062 a rdf:Property ;
  rdfs:label "preceded by"@en ;
  rdfs:comment "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 .

obo:BFO_0000156 a rdf:Property ;
  rdfs:label "has temporal occupant"@en ;
  rdfs:range obo:BFO_0000003 .

obo:GENEPIO_0000005 a rdf:Property ;
  rdfs:label "term source"@en ;
  rdfs:range xsd:string .

obo:GEO_000000012 a rdf:Property ;
  rdfs:label "member of"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0000039 a rdf:Property ;
  rdfs:label "has measurement unit label"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:IAO_0000111 a rdf:Property ;
  rdfs:label "editor preferred label" ;
  rdfs:comment "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000112 a rdf:Property ;
  rdfs:label "example of usage" ;
  rdfs:comment "A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not"@en ;
  rdfs:range xsd:string .

obo:IAO_0000114 a rdf:Property ;
  rdfs:label "has curation status" ;
  rdfs:range xsd:string .

obo:IAO_0000115 a rdf:Property ;
  rdfs:label "textual definition" ;
  rdfs:comment "English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software." ;
  rdfs:range xsd:string .

obo:IAO_0000116 a rdf:Property ;
  rdfs:label "editor note" ;
  rdfs:comment "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
  rdfs:range xsd:string .

obo:IAO_0000117 a rdf:Property ;
  rdfs:label "term editor" ;
  rdfs:comment "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
  rdfs:range xsd:string .

obo:IAO_0000118 a rdf:Property ;
  rdfs:label "alternative term" ;
  rdfs:comment "An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000119 a rdf:Property ;
  rdfs:label "definition source" ;
  rdfs:comment "formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
  rdfs:range xsd:string .

obo:IAO_0000142 a rdf:Property ;
  rdfs:label "mentions"@en ;
  rdfs:comment "An information artifact IA mentions an entity E exactly when it has a component/part that denotes E"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:IAO_0000231 a rdf:Property ;
  rdfs:label "has obsolescence reason"@en ;
  rdfs:comment "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en ;
  rdfs:range xsd:string .

obo:IAO_0000232 a rdf:Property ;
  rdfs:label "curator note" ;
  rdfs:comment "An administrative note of use for a curator but of no use for a user"@en ;
  rdfs:range xsd:string .

obo:IAO_0000234 a rdf:Property ;
  rdfs:label "ontology term requester"@en ;
  rdfs:comment "The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition." ;
  rdfs:range xsd:string .

obo:IAO_0000412 a rdf:Property ;
  rdfs:label "imported from"@en ;
  rdfs:comment "For external terms/classes, the ontology from which the term was imported"@en ;
  rdfs:range xsd:string .

obo:IAO_0000424 a rdf:Property ;
  rdfs:label "expand expression to"@en ;
  rdfs:comment "A macro expansion tag applied to an object property (or possibly a data property)  which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en ;
  rdfs:range xsd:string .

obo:IAO_0000425 a rdf:Property ;
  rdfs:label "expand assertion to" ;
  rdfs:range xsd:string .

obo:IAO_0000581 a rdf:Property ;
  rdfs:label "has time stamp"@en ;
  rdfs:comment "relates a time stamped measurement datum to the time measurement datum that denotes the time when the measurement was taken"@en ;
  rdfs:range obo:IAO_0000416 ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:IAO_0000583 a rdf:Property ;
  rdfs:label "has measurement datum"@en ;
  rdfs:comment "relates a time stamped measurement datum to the measurement datum that was measured"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:IAO_0000589 a rdf:Property ;
  rdfs:label "OBO foundry unique label"@en ;
  rdfs:comment "An alternative name for a class or property which is unique across the OBO Foundry."@en ;
  rdfs:range xsd:string .

obo:IAO_0000601 a rdf:Property ;
  rdfs:label "has associated axiom(nl)"@en ;
  rdfs:range xsd:string .

obo:IAO_0000602 a rdf:Property ;
  rdfs:label "has associated axiom(fol)"@en ;
  rdfs:range xsd:string .

obo:IAO_0010000 a rdf:Property ;
  rdfs:label "has axiom label"@en ;
  rdfs:range xsd:string .

obo:IAO_0020018 a rdf:Property ;
  rdfs:label "is designated by"@en ;
  rdfs:comment "p1 is designated by p2, if p2 is an information content entity that represents p1 in a linguistic context."@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:IAO_0100001 a rdf:Property ;
  rdfs:label "term replaced by" ;
  rdfs:comment """Use on obsolete terms, relating the term to another term that can be used as a substitute

Add as annotation triples in the granting ontology""" ;
  rdfs:range xsd:string .

obo:NGBO_6000380 a rdf:Property ;
  rdfs:label "trace_from"@en ;
  rdfs:comment "A relation that is used to follow traceability of specimen activity" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:NGBO_6000381 a rdf:Property ;
  rdfs:label "track_to"@en ;
  rdfs:comment "A relation that is used to track specimen activity" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:NGBO_6000690 a rdf:Property ;
  rdfs:label "userEmailId"@en ;
  rdfs:comment "A data property that set user email ID" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:NGBO_6000691 a rdf:Property ;
  rdfs:label "userID"@en ;
  rdfs:comment "A data property that set user ID" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:NGBO_6000692 a rdf:Property ;
  rdfs:label "userPassword"@en ;
  rdfs:comment "A data property that set user password" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:NGBO_6000693 a rdf:Property ;
  rdfs:label "userName"@en ;
  rdfs:comment "A data property that set user name" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000107 a rdf:Property ;
  rdfs:label "provides_service_consumer_with" ;
  rdfs:comment "A relation between a service and the primary processual part of the service that is performed by the provider for the consumer." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000051 .

obo:OBI_0000295 a rdf:Property ;
  rdfs:label "is_specified_input_of"@en ;
  rdfs:comment "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000056 .

obo:OBI_0000643 a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:OBI_0000846 a rdf:Property ;
  rdfs:label "is member of organization" ;
  rdfs:comment "Relating a legal person or organization to an organization in the case where the legal person or organization has a role as member of the organization." ;
  rdfs:range obo:OBI_0000245 .

obo:OBI_0001927 a rdf:Property ;
  rdfs:label "specifies value of" ;
  rdfs:comment "A relation between a value specification and an entity which the specification is about." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:IAO_0000136 .

obo:OMIABIS_0000008 a rdf:Property ;
  rdfs:label "owns"@en ;
  rdfs:range xsd:string .

obo:OMIABIS_0000009 a rdf:Property ;
  rdfs:label "administrates"@en ;
  rdfs:comment "a administrates b if c owns b and some rights and obligations grounded in the owning relation regarding b are transferred  from c to a."@en ;
  rdfs:range xsd:string .

obo:OMRSE_00000020 a rdf:Property ;
  rdfs:label "is-aggregate-of" ;
  rdfs:comment """We anticipate BFO 2.0 including and defining this relation.  When it does, we will obsolete this property and declare it equivalent to the BFO 2.0 relation.
"""@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0000053 a rdf:Property ;
  rdfs:label "bearer_of"@en ;
  rdfs:comment "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence"@en ;
  rdfs:range obo:BFO_0000020 .

obo:RO_0000080 a rdf:Property ;
  rdfs:label "quality of"@en ;
  rdfs:comment "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000081 a rdf:Property ;
  rdfs:label "role of"@en ;
  rdfs:comment "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0001001 a rdf:Property ;
  rdfs:label "derives into"@en ;
  rdfs:comment "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0001015 a rdf:Property ;
  rdfs:label "location of" ;
  rdfs:comment "a relation between two independent continuants, the location and the target, in which the target is entirely within the location"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0001025 .

obo:RO_0001019 a rdf:Property ;
  rdfs:label "contains" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002001 a rdf:Property ;
  rdfs:label "aligned with"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002009 a rdf:Property ;
  rdfs:label "cell expresses" ;
  rdfs:comment "A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002292 .

obo:RO_0002180 a rdf:Property ;
  rdfs:label "has component"@en ;
  rdfs:comment "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002200 a rdf:Property ;
  rdfs:label "has phenotype"@en ;
  rdfs:comment "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002201 a rdf:Property ;
  rdfs:label "phenotype of"@en ;
  rdfs:comment "inverse of has phenotype" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002222 a rdf:Property ;
  rdfs:label "temporal relation"@en ;
  rdfs:comment "A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations." ;
  rdfs:range obo:BFO_0000003 .

obo:RO_0002223 a rdf:Property ;
  rdfs:label "starts"@en ;
  rdfs:comment "inverse of starts with" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002222 , obo:BFO_0000050 .

obo:RO_0002233 a rdf:Property ;
  rdfs:label "has input"@en ;
  rdfs:comment "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0002234 a rdf:Property ;
  rdfs:label "has output"@en ;
  rdfs:comment "p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0000057 .

obo:RO_0002244 a rdf:Property ;
  rdfs:label "related via exposure to" ;
  rdfs:comment "Any relationship between an exposure event or process and any other entity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002245 a rdf:Property ;
  rdfs:label "over-expressed in" ;
  rdfs:comment "g is over-expressed in t iff g is expressed in t, and the expression level of g is increased relative to some background." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002246 a rdf:Property ;
  rdfs:label "under-expressed in" ;
  rdfs:comment "g is under-expressed in t iff g is expressed in t, and the expression level of g is decreased relative to some background." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002291 a rdf:Property ;
  rdfs:label "ubiquitously expressed in"@en ;
  rdfs:comment "x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002292 a rdf:Property ;
  rdfs:label "expresses"@en ;
  rdfs:comment "Inverse of 'expressed in'" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002293 a rdf:Property ;
  rdfs:label "ubiquitously expresses"@en ;
  rdfs:comment "inverse of ubiquiotously expressed in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002292 .

obo:RO_0002302 a rdf:Property ;
  rdfs:label "is treated by substance" ;
  rdfs:comment "Inverse of 'is substance that treats'" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002350 a rdf:Property ;
  rdfs:label "member of"@en ;
  rdfs:comment "is member of is a mereological relation between a item and a collection." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000050 .

obo:RO_0002353 a rdf:Property ;
  rdfs:label "output of"@en ;
  rdfs:comment "inverse of has output" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002410 a rdf:Property ;
  rdfs:label "causally related to"@en ;
  rdfs:comment "This relation groups causal relations between material entities and causal relations between processes" ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0002607 a rdf:Property ;
  rdfs:label "is marker for" ;
  rdfs:comment "c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002610 .

obo:RO_0002608 a rdf:Property ;
  rdfs:label "process has causal agent" ;
  rdfs:comment "Inverse of 'causal agent in process'" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002610 a rdf:Property ;
  rdfs:label "correlated with" ;
  rdfs:comment "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ;
  rdfs:range <https://w3id.org/linkml/Any> .

obo:RO_0003302 a rdf:Property ;
  rdfs:label "causes or contributes to condition"@en ;
  rdfs:comment "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0003310 a rdf:Property ;
  rdfs:label "condition ameliorated by"@en ;
  rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0003311 a rdf:Property ;
  rdfs:label "condition exacerbated by"@en ;
  rdfs:comment "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004017 a rdf:Property ;
  rdfs:label "realizable has basis in" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004018 a rdf:Property ;
  rdfs:label "is basis for realizable" ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004020 a rdf:Property ;
  rdfs:label "disease has basis in dysfunction of" ;
  rdfs:comment "A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004021 a rdf:Property ;
  rdfs:label "disease has basis in disruption of" ;
  rdfs:comment "A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process." ;
  rdfs:range obo:BFO_0000015 ;
  rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004030 a rdf:Property ;
  rdfs:label "disease arises from structure" ;
  rdfs:comment "A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0040035 a rdf:Property ;
  rdfs:label "disease relationship" ;
  rdfs:comment "This relation groups  relations between diseases and any other kind of entity." ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://semanticscience.org/resource/SIO_000001> a rdf:Property ;
  rdfs:label "is related to"@en ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://semanticscience.org/resource/SIO_000008> a rdf:Property ;
  rdfs:label "has attribute"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000001> .

<http://semanticscience.org/resource/SIO_000011> a rdf:Property ;
  rdfs:label "is attribute of"@en ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000001> .

<http://semanticscience.org/resource/SIO_000255> a rdf:Property ;
  rdfs:label "has annotation"@en ;
  rdfs:range <http://semanticscience.org/resource/SIO_000078> ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000008> .

<http://semanticscience.org/resource/SIO_000671> a rdf:Property ;
  rdfs:label "has identifier"@en ;
  rdfs:range <http://semanticscience.org/resource/SIO_000115> ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000008> .

<http://semanticscience.org/resource/SIO_000673> a rdf:Property ;
  rdfs:label "has unique identifier"@en ;
  rdfs:range <http://semanticscience.org/resource/SIO_000675> ;
  rdfs:subPropertyOf <http://semanticscience.org/resource/SIO_000671> .

<http://www.bioassayontology.org/bao#BAO_0002008> a rdf:Property ;
  rdfs:label "has form" ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://www.ebi.ac.uk/efo/swo/SWO_0000741> a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .

<http://www.ebi.ac.uk/swo/SWO_0000131> a rdf:Property ;
  rdfs:label "directly preceded by" ;
  rdfs:comment "Entity A is 'directly preceded by' entity B if there are no intermediate entities temporally between the two entities. WIthin SWO this property is mainly used to describe versions of entities such as software." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000060 .

<http://www.ebi.ac.uk/swo/SWO_0000132> a rdf:Property ;
  rdfs:label "directly followed by"@en ;
  rdfs:comment "'directly followed by' is an object property which further specializes the parent 'followed by' property. In the assertion 'C directly followed by C1', says that Cs generally are immediately followed by C1s." ;
  rdfs:range xsd:string ;
  rdfs:subPropertyOf obo:BFO_0000063 .

<http://www.obofoundry.org/ro/ro.owl#contained_in> a rdf:Property ;
  rdfs:range <https://w3id.org/linkml/Any> .
