PREFIX obo:
PREFIX rdf:
PREFIX rdfs:
PREFIX xsd:
obo:MPATH_331 a rdfs:Class ;
rdfs:label "sertoli cell tumor" ;
rdfs:comment "Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1)." ;
rdfs:subClassOf obo:MPATH_323 .
obo:MPATH_874 a rdfs:Class ;
rdfs:label "plasmacytosis" ;
rdfs:comment "Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_683 a rdfs:Class ;
rdfs:label "degenerative arthritis" ;
rdfs:subClassOf obo:MPATH_195 , obo:MPATH_25 , obo:MPATH_684 .
obo:MPATH_275 a rdfs:Class ;
rdfs:label "comedocarcinoma" ;
rdfs:comment "Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_839 a rdfs:Class ;
rdfs:label "anaplastic hepatocellular carcinoma" ;
rdfs:comment "anaplastic carcinoma of the liver." ;
rdfs:subClassOf obo:MPATH_357 , obo:MPATH_838 .
obo:MPATH_424 a rdfs:Class ;
rdfs:label "intravascular leiomyomatosis" ;
rdfs:comment "Benign leiomyoma that invades vascular spaces. (M-8890/1)." ;
rdfs:subClassOf obo:MPATH_423 .
obo:MPATH_507 a rdfs:Class ;
rdfs:label "mast cell sarcoma" ;
rdfs:comment "Solid tumor mass composed of mast cells." ;
rdfs:subClassOf obo:MPATH_504 .
obo:MPATH_5 a rdfs:Class ;
rdfs:label "bridging necrosis" ;
rdfs:comment "Area of liver necrosis that bridges adjacent portal areas and central veins." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_637 a rdfs:Class ;
rdfs:label "bursal cyst" ;
rdfs:comment "A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa." ;
rdfs:subClassOf obo:MPATH_62 .
obo:MPATH_423 a rdfs:Class ;
rdfs:label "myomatous tumor" ;
rdfs:comment "Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_350 a rdfs:Class ;
rdfs:label "mastocytoma" ;
rdfs:comment "obsolete. See MPATH507" .
obo:MPATH_531 a rdfs:Class ;
rdfs:label "B-natural killer cell lymphoma" ;
rdfs:comment "Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype." ;
rdfs:subClassOf obo:MPATH_516 .
obo:MPATH_417 a rdfs:Class ;
rdfs:label "lipoma" ;
rdfs:comment "Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0)." ;
rdfs:subClassOf obo:MPATH_415 .
obo:MPATH_809 a rdfs:Class ;
rdfs:label "nuchal edema" ;
rdfs:comment "Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph." ;
rdfs:subClassOf obo:MPATH_109 .
obo:MPATH_145 a rdfs:Class ;
rdfs:label "fat cell hyperplasia" ;
rdfs:comment "Benign proliferation of adipose tissue." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_755 a rdfs:Class ;
rdfs:label "pulmonary interstitial mineralisation" ;
rdfs:comment "Small foci of mineralization within the interstitium between alveoli." ;
rdfs:subClassOf obo:MPATH_555 , obo:MPATH_757 .
obo:MPATH_857 a rdfs:Class ;
rdfs:label "multifocal bullous emphysema" ;
rdfs:comment "mutilocular bullous emphysema" ;
rdfs:subClassOf obo:MPATH_856 .
obo:MPATH_536 a rdfs:Class ;
rdfs:label "precursor T-cell neoplasms" ;
rdfs:comment "Neoplasms of precursor T cells." ;
rdfs:subClassOf obo:MPATH_535 .
obo:MPATH_585 a rdfs:Class ;
rdfs:label "acidophilic macrophage pneumonia" ;
rdfs:comment "A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals." ;
rdfs:subClassOf obo:MPATH_877 .
obo:MPATH_179 a rdfs:Class ;
rdfs:label "fibrin deposition" ;
rdfs:comment "Deposition of fibrin." ;
rdfs:subClassOf obo:MPATH_176 .
obo:MPATH_85 a rdfs:Class ;
rdfs:label "transdifferentiation" ;
rdfs:comment "Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_434 a rdfs:Class ;
rdfs:label "neurilemmoma" ;
rdfs:comment "obsolete. Use schwannoma MPATH438" .
obo:MPATH_265 a rdfs:Class ;
rdfs:label "adenofibroma" ;
rdfs:comment "A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0)." ;
rdfs:subClassOf obo:MPATH_264 .
obo:MPATH_355 a rdfs:Class ;
rdfs:label "cholangiofibroma" ;
rdfs:comment "Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant." ;
rdfs:subClassOf obo:MPATH_352 .
obo:MPATH_250 a rdfs:Class ;
rdfs:label "medulloblastoma" ;
rdfs:comment "Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS." ;
rdfs:subClassOf obo:MPATH_373 .
obo:MPATH_82 a rdfs:Class ;
rdfs:label "persistent embryonic structure" ;
rdfs:comment "Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly)." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_462 a rdfs:Class ;
rdfs:label "cataract; nuclear and cortical" ;
rdfs:comment "Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule." ;
rdfs:subClassOf obo:MPATH_29 .
obo:MPATH_225 a rdfs:Class ;
rdfs:label "eccrine gland adenocarcinoma" ;
rdfs:comment "Malignant neoplasm of the eccrine gland (M-8413/3)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_268 .
obo:MPATH_93 a rdfs:Class ;
rdfs:label "cardiac septation defect" ;
rdfs:comment "Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure." ;
rdfs:subClassOf obo:MPATH_92 .
obo:MPATH_409 a rdfs:Class ;
rdfs:label "fibrous histiocytoma" ;
rdfs:comment "Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0)." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_744 a rdfs:Class ;
rdfs:label "pigmentary incontinence" ;
rdfs:comment "Release of melanin pigment in the dermis." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_290 a rdfs:Class ;
rdfs:label "lobular carcinoma in situ" ;
rdfs:comment "Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_556 .
obo:MPATH_802 a rdfs:Class ;
rdfs:label "rectal prolapse" ;
rdfs:comment "Eversion through the anus." ;
rdfs:subClassOf obo:MPATH_626 .
obo:MPATH_731 a rdfs:Class ;
rdfs:label "Leydig cell hyperplasia" ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_129 a rdfs:Class ;
rdfs:label "epithelial dysplasia" ;
rdfs:comment "obsolete due to renaming of preneoplastic dysplasias and Intraepithelial neoplasias Use MPATH:128." .
obo:MPATH_863 a rdfs:Class ;
rdfs:label "focal ulcerative dermatitis" ;
rdfs:comment "circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process." ;
rdfs:subClassOf obo:MPATH_196 .
obo:MPATH_17 a rdfs:Class ;
rdfs:label "subcellular defect" ;
rdfs:comment "Defect of a subcellular structure or organelle." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_204 a rdfs:Class ;
rdfs:label "chronic/recurrent inflammatory disease" ;
rdfs:comment "obsolete. Subsumed into MPATH: 214." .
obo:MPATH_11 a rdfs:Class ;
rdfs:label "hemorrhagic necrosis" ;
rdfs:comment "Necrosis associated with local hemorrhage." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_709 a rdfs:Class ;
rdfs:label "alveolar rhabdomyosarcoma" ;
rdfs:comment "Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation." ;
rdfs:subClassOf obo:MPATH_428 .
obo:MPATH_484 a rdfs:Class ;
rdfs:label "hyperplastic nodule" ;
rdfs:comment "Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_322 a rdfs:Class ;
rdfs:label "teratoma" ;
rdfs:comment "Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_310 .
obo:MPATH_44 a rdfs:Class ;
rdfs:label "melanin deposition" ;
rdfs:comment "Intra or extracellular deposition of melanin." ;
rdfs:subClassOf obo:MPATH_613 .
obo:MPATH_238 a rdfs:Class ;
rdfs:label "hemangioblastoma" ;
rdfs:comment "A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1)." ;
rdfs:subClassOf obo:MPATH_235 .
obo:MPATH_762 a rdfs:Class ;
rdfs:label "thyroid follicle pleomorphism" ;
rdfs:comment "Thyroid gland follicles are filled with colloid but vary greatly in size." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_71 a rdfs:Class ;
rdfs:label "fusion process defect" ;
rdfs:comment "Failure of two or more structures ( not voids or lumens) to join together." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_63 a rdfs:Class ;
rdfs:label "depletion" ;
rdfs:comment "The removal of accumulated fluids or solids." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_518 a rdfs:Class ;
rdfs:label "precursor B -cell lymphoblastic lymphoma/leukaemia" ;
rdfs:comment "Lymphoma originating in a precursor B-cell." ;
rdfs:subClassOf obo:MPATH_517 .
obo:MPATH_118 a rdfs:Class ;
rdfs:label "systemic embolism" ;
rdfs:comment "Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_579 a rdfs:Class ;
rdfs:label "ulcer" ;
rdfs:comment "Loss of epithelium and the basement membrane (full thickness). Cf Erosion." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_307 a rdfs:Class ;
rdfs:label "thyroid C-cell adenoma" ;
rdfs:comment "Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_383 a rdfs:Class ;
rdfs:label "cementoblastoma" ;
rdfs:comment "A neoplasm arising from the periodontal ligament (M-9273/0)." ;
rdfs:subClassOf obo:MPATH_379 .
obo:MPATH_22 a rdfs:Class ;
rdfs:label "mitochondrial defect" ;
rdfs:comment "Defect in the structure or function of the mitochondria." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_596 a rdfs:Class ;
rdfs:label "pathological process" ;
rdfs:comment "The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion." ;
rdfs:subClassOf obo:MPATH_0 .
obo:MPATH_343 a rdfs:Class ;
rdfs:label "lymphoma" ;
rdfs:comment "obsolete; divided between subtypes of MPATH516, MPATH535" .
obo:MPATH_616 a rdfs:Class ;
rdfs:label "hyperostosis" ;
rdfs:comment "Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions." ;
rdfs:subClassOf obo:MPATH_159 .
obo:MPATH_889 a rdfs:Class ;
rdfs:label "Hirano body" ;
rdfs:comment " intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID: 21978358" ;
rdfs:subClassOf obo:MPATH_45 .
obo:MPATH_305 a rdfs:Class ;
rdfs:label "serous cystadenoma" ;
rdfs:comment "Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_723 a rdfs:Class ;
rdfs:label "fibromatosis" ;
rdfs:comment "Systemic manifestation of MPATH: 407." ;
rdfs:subClassOf obo:MPATH_407 .
obo:MPATH_220 a rdfs:Class ;
rdfs:label "apocrine adenocarcinoma" ;
rdfs:comment "Carcinoma of the glandular epithelium of apocrine glands (M-8401/3)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_268 .
obo:MPATH_467 a rdfs:Class ;
rdfs:label "glaucoma; angle closure" ;
rdfs:comment "Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions." ;
rdfs:subClassOf obo:MPATH_32 .
obo:MPATH_435 a rdfs:Class ;
rdfs:label "neurofibroma" ;
rdfs:comment "Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0)." ;
rdfs:subClassOf obo:MPATH_433 .
obo:MPATH_376 a rdfs:Class ;
rdfs:label "neuroblastoma" ;
rdfs:comment "A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3)." ;
rdfs:subClassOf obo:MPATH_373 .
obo:MPATH_52 a rdfs:Class ;
rdfs:label "lipid depletion" ;
rdfs:comment "Reduction in cellular or plasma lipid content." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_489 a rdfs:Class ;
rdfs:label "stomach, oesophagus and pancreatic intra-epithelial neoplasia" ;
rdfs:subClassOf obo:MPATH_128 .
obo:MPATH_163 a rdfs:Class ;
rdfs:label "apocrine metaplasia" ;
rdfs:comment "Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_156 a rdfs:Class ;
rdfs:label "parakeratosis" ;
rdfs:comment "Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum." ;
rdfs:subClassOf obo:MPATH_154 .
obo:MPATH_878 a rdfs:Class ;
rdfs:label "foreign body aspiration pneumonia" ;
rdfs:comment "Pneumonia caused by aspiration of a foreign body." ;
rdfs:subClassOf obo:MPATH_877 .
obo:MPATH_466 a rdfs:Class ;
rdfs:label "glaucoma; open angle" ;
rdfs:comment "Failure of drainage of the eye for unknown reasons." ;
rdfs:subClassOf obo:MPATH_32 .
obo:MPATH_578 a rdfs:Class ;
rdfs:label "trichoblastoma" ;
rdfs:comment "Basaloid neoplasm with frequent primitive hair follicles." ;
rdfs:subClassOf obo:MPATH_575 .
obo:MPATH_751 a rdfs:Class ;
rdfs:label "pigment dispersion" ;
rdfs:comment "Free pigment in anterior chamber/elsewhere in eye." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_311 a rdfs:Class ;
rdfs:label "dermoid cyst" ;
rdfs:comment "Cystic ovarian teratomas with different mature cell types (M-9084/3)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_310 , obo:MPATH_549 .
obo:MPATH_813 a rdfs:Class ;
rdfs:label "epidermolysis bullosa lesions" ;
rdfs:comment "Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes." ;
rdfs:subClassOf obo:MPATH_812 .
obo:MPATH_187 a rdfs:Class ;
rdfs:label "incomplete parenchymal regeneration" ;
rdfs:comment "Incomplete healing usually accompanied by fibrosis." ;
rdfs:subClassOf obo:MPATH_185 .
obo:MPATH_316 a rdfs:Class ;
rdfs:label "mixed germ cell tumor" ;
rdfs:comment "Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_310 .
obo:MPATH_102 a rdfs:Class ;
rdfs:label "labyrinth zone defect" ;
rdfs:comment "Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta." ;
rdfs:subClassOf obo:MPATH_100 .
obo:MPATH_619 a rdfs:Class ;
rdfs:label "truncoconal septal defect" ;
rdfs:comment "Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus." ;
rdfs:subClassOf obo:MPATH_93 .
obo:MPATH_286 a rdfs:Class ;
rdfs:label "intraductal papillomatosis" ;
rdfs:comment "Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0)." ;
rdfs:subClassOf obo:MPATH_267 .
obo:MPATH_654 a rdfs:Class ;
rdfs:label "non-Langerhans cell histiocytosis" ;
rdfs:subClassOf obo:MPATH_652 .
obo:MPATH_712 a rdfs:Class ;
rdfs:label "heterotaxy" ;
rdfs:subClassOf obo:MPATH_470 .
obo:MPATH_701 a rdfs:Class ;
rdfs:label "developmental aspermia" ;
rdfs:subClassOf obo:MPATH_599 , obo:MPATH_796 .
obo:MPATH_141 a rdfs:Class ;
rdfs:label "inflammatory polyp" ;
rdfs:comment "A projecting mass of granulation tissue which may become covered by regenerating epithelium." ;
rdfs:subClassOf obo:MPATH_491 .
obo:MPATH_560 a rdfs:Class ;
rdfs:label "cribriform adenocarcinoma" ;
rdfs:comment "Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_366 a rdfs:Class ;
rdfs:label "neuroendocrine tumor" ;
rdfs:comment "Neoplasms derived from the neuroendocrine system." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_74 a rdfs:Class ;
rdfs:label "hamartoma" ;
rdfs:comment "A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_563 a rdfs:Class ;
rdfs:label "mucinous carcinoma" ;
rdfs:comment "carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_142 a rdfs:Class ;
rdfs:label "intraductal hyperplasia" ;
rdfs:comment "Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia." ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_9 a rdfs:Class ;
rdfs:label "fibrinoid necrosis" ;
rdfs:comment "Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_499 a rdfs:Class ;
rdfs:label "nesidioblastosis" ;
rdfs:comment "Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion." ;
rdfs:subClassOf obo:MPATH_64 .
obo:MPATH_300 a rdfs:Class ;
rdfs:label "pineoblastoma" ;
rdfs:comment "Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3)." ;
rdfs:subClassOf obo:MPATH_267 .
obo:MPATH_279 a rdfs:Class ;
rdfs:label "follicular adenoma" ;
rdfs:comment "Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_867 a rdfs:Class ;
rdfs:label "hepatic central vein perivascular fibrosis" ;
rdfs:comment "Major hepatic vein surrounded by fibrous connective tissue." ;
rdfs:subClassOf obo:MPATH_181 .
obo:MPATH_327 a rdfs:Class ;
rdfs:label "gynandroblastoma" ;
rdfs:comment "obsolete Use sertoli-leydig cell tumor MPATH 332" .
obo:MPATH_419 a rdfs:Class ;
rdfs:label "lymphatic vessel tumor" ;
rdfs:comment "Neoplasms of the lymphatic vessels." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_390 a rdfs:Class ;
rdfs:label "chondroblastoma, malignant" ;
rdfs:comment "Subsumed into MPATH:389" .
obo:MPATH_365 a rdfs:Class ;
rdfs:label "mesothelioma" ;
rdfs:comment "Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3)." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_198 a rdfs:Class ;
rdfs:label "immune mediated hemolytic anaemia" ;
rdfs:comment "An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_740 a rdfs:Class ;
rdfs:label "drusen" ;
rdfs:comment "Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium." ;
rdfs:subClassOf obo:MPATH_45 .
obo:MPATH_473 a rdfs:Class ;
rdfs:label "developmental cystic dysplasia" ;
rdfs:comment "Developmental dysplasia showing epithelial cell bounded cavities." ;
rdfs:subClassOf obo:MPATH_64 .
obo:MPATH_648 a rdfs:Class ;
rdfs:label "interstitial pancreatitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_885 a rdfs:Class ;
rdfs:label "metastatic tumor" ;
rdfs:comment "metastatic tumour of unspecified origin" ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_361 a rdfs:Class ;
rdfs:label "naevus" ;
rdfs:comment "Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0)." ;
rdfs:subClassOf obo:MPATH_358 .
obo:MPATH_739 a rdfs:Class ;
rdfs:label "sub-retinal hemorrhage" ;
rdfs:comment "Extravascular blood between retina and choroid" ;
rdfs:subClassOf obo:MPATH_119 .
obo:MPATH_60 a rdfs:Class ;
rdfs:label "communication defect" ;
rdfs:comment "Failure of two cavities, voids or lumens to connect." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_766 a rdfs:Class ;
rdfs:label "intestinal amyloidosis" ;
rdfs:comment "The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein." ;
rdfs:subClassOf obo:MPATH_34 .
obo:MPATH_40 a rdfs:Class ;
rdfs:label "hyalinosis" ;
rdfs:comment "Intracellular deposition of eosinophilic material." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_193 a rdfs:Class ;
rdfs:label "type IV hypersensitivity" ;
rdfs:comment "An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact." ;
rdfs:subClassOf obo:MPATH_189 .
obo:MPATH_33 a rdfs:Class ;
rdfs:label "intracellular and extracellular accumulation" ;
rdfs:comment "Accumulation of substances within, on the surface of or between cells." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_344 a rdfs:Class ;
rdfs:label "follicle center cell lymphoma" ;
rdfs:comment "obsolete; see MPATH 522" .
obo:MPATH_249 a rdfs:Class ;
rdfs:label "glioma" ;
rdfs:comment "Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3)." ;
rdfs:subClassOf obo:MPATH_565 .
obo:MPATH_182 a rdfs:Class ;
rdfs:label "gliosis" ;
rdfs:comment "Proliferation of astrocytes in an area of damage in the brain or spinal cord." ;
rdfs:subClassOf obo:MPATH_176 .
obo:MPATH_828 a rdfs:Class ;
rdfs:label "focal dermatitis" ;
rdfs:comment "locally demarcated region of inflammation in the skin" ;
rdfs:subClassOf obo:MPATH_196 .
obo:MPATH_207 a rdfs:Class ;
rdfs:label "immunodeficiency - lymphoid defect" ;
rdfs:comment "Primary defect in the lymphoid arm of the immune system." ;
rdfs:subClassOf obo:MPATH_206 .
obo:MPATH_477 a rdfs:Class ;
rdfs:label "choristoma" ;
rdfs:comment "Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly)." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_264 a rdfs:Class ;
rdfs:label "fibroepithelial tumor" ;
rdfs:comment "Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030)." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_445 a rdfs:Class ;
rdfs:label "papilloma" ;
rdfs:comment "A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0)." ;
rdfs:subClassOf obo:MPATH_264 , obo:MPATH_556 .
obo:MPATH_666 a rdfs:Class ;
rdfs:label "periodontitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_152 a rdfs:Class ;
rdfs:label "basal cell hyperplasia" ;
rdfs:comment "Benign proliferation of the basal layer cells of the skin." ;
rdfs:subClassOf obo:MPATH_149 .
obo:MPATH_672 a rdfs:Class ;
rdfs:label "mastocytosis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_749 a rdfs:Class ;
rdfs:label "focal pulmonary fibrosis" ;
rdfs:comment "Various degrees of pulmonary interstitial fibrosis." ;
rdfs:subClassOf obo:MPATH_181 .
obo:MPATH_478 a rdfs:Class ;
rdfs:label "angiogenesis defect" ;
rdfs:comment "Abnormality in developmental angiogenesis." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_107 a rdfs:Class ;
rdfs:label "congestion" ;
rdfs:comment "Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ." ;
rdfs:subClassOf obo:MPATH_106 .
obo:MPATH_28 a rdfs:Class ;
rdfs:label "atherosclerosis" ;
rdfs:comment "Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_167 a rdfs:Class ;
rdfs:label "intestinal metaplasia" ;
rdfs:comment "Appearance of heterotopic intestinal epithelium." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_402 a rdfs:Class ;
rdfs:label "glomus tumor" ;
rdfs:comment "obsolete; use paraganglioma M-8711/0) or specific example terms, MPATH399-401." .
obo:MPATH_600 a rdfs:Class ;
rdfs:label "branching defect" ;
rdfs:comment "Aberrant branch or branching pattern of a branched structure such as the bronchus." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_661 a rdfs:Class ;
rdfs:label "foreign body gastritis" ;
rdfs:subClassOf obo:MPATH_660 .
obo:MPATH_773 a rdfs:Class ;
rdfs:label "abnormal intestine length" ;
rdfs:comment "Abnormal length of the intestine." ;
rdfs:subClassOf obo:MPATH_771 .
obo:MPATH_720 a rdfs:Class ;
rdfs:label "situs inversus" ;
rdfs:subClassOf obo:MPATH_470 .
obo:MPATH_529 a rdfs:Class ;
rdfs:label "Burkitt-like lymphoma" ;
rdfs:comment "Highly proliferative mature B-cell lymphoma, poorly defined." ;
rdfs:subClassOf obo:MPATH_519 .
obo:MPATH_675 a rdfs:Class ;
rdfs:label "psoriasiform dermatitis" ;
rdfs:subClassOf obo:MPATH_196 .
obo:MPATH_203 a rdfs:Class ;
rdfs:label "general immunodeficiency disease" ;
rdfs:comment "obsolete. Subsumed into MPATH:202" .
obo:MPATH_358 a rdfs:Class ;
rdfs:label "melanocytic tumor" ;
rdfs:comment "Tumors derived from melanocytes." ;
rdfs:subClassOf obo:MPATH_219 .
obo:MPATH_480 a rdfs:Class ;
rdfs:label "decidual defect" ;
rdfs:comment "Any defect in the formation, architecture, cellular composition or function of the maternal decidua." ;
rdfs:subClassOf obo:MPATH_100 .
obo:MPATH_795 a rdfs:Class ;
rdfs:label "psammoma body" ;
rdfs:comment "Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition." ;
rdfs:subClassOf obo:MPATH_36 .
obo:MPATH_232 a rdfs:Class ;
rdfs:label "trichoepithelioma" ;
rdfs:comment "Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0)." ;
rdfs:subClassOf obo:MPATH_575 .
obo:MPATH_213 a rdfs:Class ;
rdfs:label "acute inflammation" ;
rdfs:comment "Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_440 a rdfs:Class ;
rdfs:label "synovial sarcoma" ;
rdfs:comment "Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3)." ;
rdfs:subClassOf obo:MPATH_439 , obo:MPATH_551 .
obo:MPATH_842 a rdfs:Class ;
rdfs:label "coccygeal hemivertebrae" ;
rdfs:comment "abnormally shaped vertebral body often triangular as opposed to rectangular." ;
rdfs:subClassOf obo:MPATH_67 .
obo:MPATH_391 a rdfs:Class ;
rdfs:label "chondroma" ;
rdfs:comment "A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_481 a rdfs:Class ;
rdfs:label "pre-neoplastic lesions" ;
rdfs:comment "Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous." .
obo:MPATH_850 a rdfs:Class ;
rdfs:label "post-traumatic structural abnormality" ;
rdfs:comment "Morphological abnormality following trauma or related insult such as infection." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_398 a rdfs:Class ;
rdfs:label "paragangliomas and glomus tumor" ;
rdfs:comment "Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma." ;
rdfs:subClassOf obo:MPATH_366 .
obo:MPATH_564 a rdfs:Class ;
rdfs:label "glioblastoma" ;
rdfs:comment "Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3)." ;
rdfs:subClassOf obo:MPATH_249 .
obo:MPATH_242 a rdfs:Class ;
rdfs:label "hemangiosarcoma" ;
rdfs:comment "Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3)." ;
rdfs:subClassOf obo:MPATH_235 , obo:MPATH_551 .
obo:MPATH_719 a rdfs:Class ;
rdfs:label "bronchiectasia" ;
rdfs:subClassOf obo:MPATH_474 .
obo:MPATH_219 a rdfs:Class ;
rdfs:label "adnexal and skin appendage tumor" ;
rdfs:comment "Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_470 a rdfs:Class ;
rdfs:label "left/right axis defect" ;
rdfs:comment "Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern." ;
rdfs:subClassOf obo:MPATH_469 .
obo:MPATH_817 a rdfs:Class ;
rdfs:label "hydropic degeneration" ;
rdfs:comment "Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity." ;
rdfs:subClassOf obo:MPATH_15 .
obo:MPATH_547 a rdfs:Class ;
rdfs:label "mucous secretions" ;
rdfs:comment "Extracellular accumulation of mucous secretions." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_784 a rdfs:Class ;
rdfs:label "follicular atresia" ;
rdfs:comment "Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_495 a rdfs:Class ;
rdfs:label "glomangioma" ;
rdfs:comment "Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0)." ;
rdfs:subClassOf obo:MPATH_235 .
obo:MPATH_605 a rdfs:Class ;
rdfs:label "metaplastic tissue" ;
rdfs:comment "A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind." ;
rdfs:subClassOf obo:MPATH_126 .
obo:MPATH_243 a rdfs:Class ;
rdfs:label "central nervous system tumor" ;
rdfs:comment "Neoplasm of the neurones, glia or meninges of the CNS." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_171 a rdfs:Class ;
rdfs:label "squamous metaplasia" ;
rdfs:comment "Change of a glandular or mucosal epithelium into squamous epithelium." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_880 a rdfs:Class ;
rdfs:label "foreign body gingivitis" ;
rdfs:comment "inflammation of the tooth gum caused by a foreign body." ;
rdfs:subClassOf obo:MPATH_879 .
obo:MPATH_650 a rdfs:Class ;
rdfs:label "proliferative dermatitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_450 a rdfs:Class ;
rdfs:label "transitional cell tumor" ;
rdfs:comment "Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_824 a rdfs:Class ;
rdfs:label "myofibroma" ;
rdfs:comment "A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern." ;
rdfs:subClassOf obo:MPATH_407 .
obo:MPATH_659 a rdfs:Class ;
rdfs:label "foreign body dermatitis" ;
rdfs:subClassOf obo:MPATH_196 .
obo:MPATH_120 a rdfs:Class ;
rdfs:label "ecchymosis" ;
rdfs:comment "A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae." ;
rdfs:subClassOf obo:MPATH_119 .
obo:MPATH_611 a rdfs:Class ;
rdfs:label "glossitis" ;
rdfs:comment "Acute or chronic inflammation of the tongue." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_298 a rdfs:Class ;
rdfs:label "papillary cystadenoma" ;
rdfs:comment "A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_217 a rdfs:Class ;
rdfs:label "ulcerative inflammation" ;
rdfs:comment "Combination of inflammation, often suppurative or granulomatous, with ulceration." .
obo:MPATH_676 a rdfs:Class ;
rdfs:label "nephritis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_160 a rdfs:Class ;
rdfs:label "metaplasia" ;
rdfs:comment "Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_257 a rdfs:Class ;
rdfs:label "craniopharyngioma" ;
rdfs:comment "A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_631 a rdfs:Class ;
rdfs:label "hypertrophic tissue" ;
rdfs:comment "Tissue or cells undergoing hypertrophy, MPATH: 159." ;
rdfs:subClassOf obo:MPATH_126 .
obo:MPATH_525 a rdfs:Class ;
rdfs:label "diffuse large B-cell lymphoma, immunoblastic type" ;
rdfs:comment "Diffuse large B cell lymphoma with increased number of immunoblasts." ;
rdfs:subClassOf obo:MPATH_523 .
obo:MPATH_835 a rdfs:Class ;
rdfs:label "acute septic inflammation" ;
rdfs:comment "acute inflammation due to infection." ;
rdfs:subClassOf obo:MPATH_213 .
obo:MPATH_446 a rdfs:Class ;
rdfs:label "squamous cell carcinoma" ;
rdfs:comment "Malignant tumor derived from stratified squamous cells. (M-8070/3)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_442 , obo:MPATH_549 .
obo:MPATH_886 a rdfs:Class ;
rdfs:label "pulmonary metastasis" ;
rdfs:comment "Metastatic tumour of unspecified origin in the lung." ;
rdfs:subClassOf obo:MPATH_885 .
obo:MPATH_319 a rdfs:Class ;
rdfs:label "spermatocytic seminoma" ;
rdfs:comment "Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3)." ;
rdfs:subClassOf obo:MPATH_317 .
obo:MPATH_717 a rdfs:Class ;
rdfs:label "sequestrum" ;
rdfs:comment "Most often used in the context of bone." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_401 a rdfs:Class ;
rdfs:label "glomus jugulare tumor" ;
rdfs:comment "A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1)." ;
rdfs:subClassOf obo:MPATH_398 .
obo:MPATH_577 a rdfs:Class ;
rdfs:label "spiradenoma" ;
rdfs:comment "Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular." ;
rdfs:subClassOf obo:MPATH_575 .
obo:MPATH_380 a rdfs:Class ;
rdfs:label "ameloblastic fibroma" ;
rdfs:comment "A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0)." ;
rdfs:subClassOf obo:MPATH_379 .
obo:MPATH_492 a rdfs:Class ;
rdfs:label "membraneous glomerulonephritis" ;
rdfs:comment "Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,." ;
rdfs:subClassOf obo:MPATH_197 .
obo:MPATH_665 a rdfs:Class ;
rdfs:label "foreign body granulomatous peritonitis" ;
rdfs:subClassOf obo:MPATH_215 , obo:MPATH_663 .
obo:MPATH_406 a rdfs:Class ;
rdfs:label "dermatofibrosarcoma" ;
rdfs:comment "Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3)." ;
rdfs:subClassOf obo:MPATH_404 , obo:MPATH_551 .
obo:MPATH_558 a rdfs:Class ;
rdfs:label "adenomyoepithelioma" ;
rdfs:comment "Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_642 a rdfs:Class ;
rdfs:label "cholesterol deposition" ;
rdfs:comment "Intra or extracellular deposition of cholesterol." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_228 a rdfs:Class ;
rdfs:label "papillary hidradenoma" ;
rdfs:comment "Benign apocrine sweat gland tumor (8405/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_131 a rdfs:Class ;
rdfs:label "moderate intra-epithelial epithelial neoplasia" ;
rdfs:comment "Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone." ;
rdfs:subClassOf obo:MPATH_128 .
obo:MPATH_261 a rdfs:Class ;
rdfs:label "nephroblastoma" ;
rdfs:comment "Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_413 a rdfs:Class ;
rdfs:label "granular cell tumor" ;
rdfs:comment "Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0)." ;
rdfs:subClassOf obo:MPATH_423 .
obo:MPATH_231 a rdfs:Class ;
rdfs:label "syringoma" ;
rdfs:comment "A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0)." ;
rdfs:subClassOf obo:MPATH_219 .
obo:MPATH_1000 a rdfs:Class ;
rdfs:label "pathological phenotype observation" ;
rdfs:comment "Phenotypic observation of the presence or absence of a pathological entity." .
obo:MPATH_687 a rdfs:Class ;
rdfs:label "autoamputation" ;
rdfs:subClassOf obo:MPATH_686 .
obo:MPATH_503 a rdfs:Class ;
rdfs:label "biphenotypic leukaemia" ;
rdfs:comment "A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage." ;
rdfs:subClassOf obo:MPATH_496 .
obo:MPATH_428 a rdfs:Class ;
rdfs:label "rhabdomyosarcoma" ;
rdfs:comment "Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3)." ;
rdfs:subClassOf obo:MPATH_423 , obo:MPATH_551 .
obo:MPATH_89 a rdfs:Class ;
rdfs:label "cardiovascular developmental defect" ;
rdfs:comment "Abnormal development of the heart or vascular tissue resulting in morphological abnormality." ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_1 a rdfs:Class ;
rdfs:label "cell and tissue damage" ;
rdfs:comment "The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors." ;
rdfs:subClassOf obo:MPATH_603 .
obo:MPATH_130 a rdfs:Class ;
rdfs:label "mild intra-epithelial neoplasia" ;
rdfs:comment "Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone." ;
rdfs:subClassOf obo:MPATH_128 .
obo:MPATH_846 a rdfs:Class ;
rdfs:label "foreign body acute pododermatitis" ;
rdfs:comment "acute inflammation of the footpad caused by foreign body." ;
rdfs:subClassOf obo:MPATH_659 .
obo:MPATH_294 a rdfs:Class ;
rdfs:label "myoepithelioma" ;
rdfs:comment "Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_394 a rdfs:Class ;
rdfs:label "osteochondroma" ;
rdfs:comment "Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_38 a rdfs:Class ;
rdfs:label "copper deposition" ;
rdfs:comment "Intra and extracellular deposition of copper and copper containing proteins." ;
rdfs:subClassOf obo:MPATH_45 , obo:MPATH_555 .
obo:MPATH_696 a rdfs:Class ;
rdfs:label "spindle cell hyperplasia" ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_620 a rdfs:Class ;
rdfs:label "inter-atrial septal defect" ;
rdfs:comment "Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum." ;
rdfs:subClassOf obo:MPATH_93 .
obo:MPATH_175 a rdfs:Class ;
rdfs:label "healing and repair process" ;
rdfs:comment "The process, normal or abnormal, of damage repair or wound closure." ;
rdfs:subClassOf obo:MPATH_596 .
obo:MPATH_853 a rdfs:Class ;
rdfs:label "systemic plasmacytosis" ;
rdfs:comment "Abnormality of circulating plasma cells" ;
rdfs:subClassOf obo:MPATH_852 .
obo:MPATH_706 a rdfs:Class ;
rdfs:label "cryptorchidism" ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_691 a rdfs:Class ;
rdfs:label "pustule" ;
rdfs:subClassOf obo:MPATH_608 .
obo:MPATH_354 a rdfs:Class ;
rdfs:label "cholangiocarcinoma" ;
rdfs:comment "Malignant tumor derived from the bile duct epithelium. (M8160/3)." ;
rdfs:subClassOf obo:MPATH_352 , obo:MPATH_549 .
obo:MPATH_347 a rdfs:Class ;
rdfs:label "small lymphocytic lymphoma" ;
rdfs:comment "obsolete; see MPATH520" .
obo:MPATH_454 a rdfs:Class ;
rdfs:label "trophoblastic tumor" ;
rdfs:comment "Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_573 a rdfs:Class ;
rdfs:label "inverted transitional cell papilloma" ;
rdfs:comment "Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface." ;
rdfs:subClassOf obo:MPATH_453 .
obo:MPATH_399 a rdfs:Class ;
rdfs:label "aortic body tumor" ;
rdfs:comment "Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1)." ;
rdfs:subClassOf obo:MPATH_398 .
obo:MPATH_369 a rdfs:Class ;
rdfs:label "endocrine adenoma" .
obo:MPATH_412 a rdfs:Class ;
rdfs:label "alveolar soft part sarcoma" ;
rdfs:comment "Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3)." ;
rdfs:subClassOf obo:MPATH_404 , obo:MPATH_551 .
obo:MPATH_831 a rdfs:Class ;
rdfs:label "multifocal muscle regeneration" ;
rdfs:comment "multilocular sites of muscle regeneration with centrally located nuclei." ;
rdfs:subClassOf obo:MPATH_830 .
obo:MPATH_308 a rdfs:Class ;
rdfs:label "thyroid C-cell carcinoma" ;
rdfs:comment "Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_372 a rdfs:Class ;
rdfs:label "tumorlet" ;
rdfs:comment "Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1)." ;
rdfs:subClassOf obo:MPATH_366 .
obo:MPATH_514 a rdfs:Class ;
rdfs:label "B cell neoplasms" .
obo:MPATH_569 a rdfs:Class ;
rdfs:label "granular cell tumor" ;
rdfs:comment "Subsumed into MP:413 as incidence in meninges, whilst a characteristic lesion, is the same type of tumor as that originally classified under myomatous tumors. Describe meningeal granular cell tumor using MP:413 and the anatomical descriptor." .
obo:MPATH_820 a rdfs:Class ;
rdfs:label "goitre" ;
rdfs:comment "Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_790 a rdfs:Class ;
rdfs:label "bilateral retinal degeneration" ;
rdfs:comment "Retinal degeneration of both eyes." ;
rdfs:subClassOf obo:MPATH_737 .
obo:MPATH_387 a rdfs:Class ;
rdfs:label "odontoma" ;
rdfs:comment "Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_379 , obo:MPATH_74 .
obo:MPATH_47 a rdfs:Class ;
rdfs:label "intracellular and extracellular depletion" ;
rdfs:comment "Loss or dispersion of specific intra- and extracellular substances." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_488 a rdfs:Class ;
rdfs:label "prostate intra-epithelial neoplasia" ;
rdfs:comment "See reference for definition." ;
rdfs:subClassOf obo:MPATH_128 .
obo:MPATH_272 a rdfs:Class ;
rdfs:label "bronchioloalveolar adenoma" ;
rdfs:comment "Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_27 a rdfs:Class ;
rdfs:label "arthrosis" ;
rdfs:comment "Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_626 a rdfs:Class ;
rdfs:label "prolapse" ;
rdfs:comment "To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_221 a rdfs:Class ;
rdfs:label "apocrine adenoma" ;
rdfs:comment "Benign neoplasm of the epithelium of apocrine glands (M-8401/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_553 a rdfs:Class ;
rdfs:label "neuritis" ;
rdfs:comment "Inflammation of a nerve." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_734 a rdfs:Class ;
rdfs:label "acute blepharitis" ;
rdfs:subClassOf obo:MPATH_546 .
obo:MPATH_439 a rdfs:Class ;
rdfs:label "synovial-like tumor" ;
rdfs:comment "Neoplasms of synovial origin." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_283 a rdfs:Class ;
rdfs:label "intraductal carcinoma" ;
rdfs:comment "In situ carcinoma of the mammary ductal epithelium. (M- 8500/2)." .
obo:MPATH_253 a rdfs:Class ;
rdfs:label "sub-ependymoma" ;
rdfs:comment "Neoplasm derived from sub-ependymal astrocytes (M-9383/1)." ;
rdfs:subClassOf obo:MPATH_249 .
obo:MPATH_542 a rdfs:Class ;
rdfs:label "T natural killer cell lymphoma" ;
rdfs:comment "Neoplasm of large granular T cells of CD8 phenotype." ;
rdfs:subClassOf obo:MPATH_535 .
obo:MPATH_105 a rdfs:Class ;
rdfs:label "circulatory disorder" ;
rdfs:comment "Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body." ;
rdfs:subClassOf obo:MPATH_603 .
obo:MPATH_728 a rdfs:Class ;
rdfs:label "pulmonary hemosiderosis" ;
rdfs:subClassOf obo:MPATH_726 .
obo:MPATH_254 a rdfs:Class ;
rdfs:label "complex tumor" ;
rdfs:comment "Tumors showing multiple histological componants/differentiation." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_133 a rdfs:Class ;
rdfs:label "hypoplasia" ;
rdfs:comment "Small organ or structure; failure to develop to normal size." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_315 a rdfs:Class ;
rdfs:label "gonadoblastoma" ;
rdfs:comment "Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1)." ;
rdfs:subClassOf obo:MPATH_310 .
obo:MPATH_49 a rdfs:Class ;
rdfs:label "demyelination" ;
rdfs:comment "Reduction of myelin content in neuronal sheath." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_29 a rdfs:Class ;
rdfs:label "cataract" ;
rdfs:comment "Opacity of the lens." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_53 a rdfs:Class ;
rdfs:label "osteopenia" ;
rdfs:comment "Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_174 a rdfs:Class ;
rdfs:label "osseous metaplasia" ;
rdfs:comment "Metaplasia resulting in formation of bone." ;
rdfs:subClassOf obo:MPATH_605 .
obo:MPATH_524 a rdfs:Class ;
rdfs:label "diffuse large B-cell lymphoma, centroblastic type" ;
rdfs:comment "Diffuse follicular centre cell lymphoma mainly composed of centroblasts." ;
rdfs:subClassOf obo:MPATH_523 .
obo:MPATH_574 a rdfs:Class ;
rdfs:label "nephroblastomatosis" ;
rdfs:comment "Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests." ;
rdfs:subClassOf obo:MPATH_64 .
obo:MPATH_397 a rdfs:Class ;
rdfs:label "osteosarcoma" ;
rdfs:comment "Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_752 a rdfs:Class ;
rdfs:label "barbered" ;
rdfs:comment "loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_291 a rdfs:Class ;
rdfs:label "medullary carcinoma" ;
rdfs:comment "Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_858 a rdfs:Class ;
rdfs:label "capillary hemangioma" ;
rdfs:comment "Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma." ;
rdfs:subClassOf obo:MPATH_240 .
obo:MPATH_736 a rdfs:Class ;
rdfs:label "ovarian follicular cyst" ;
rdfs:comment "A variety of cysts develop in the ovary. They are subdivided based on where they develop anatomically. Ovarian follicles in this case become large and fluid filled." ;
rdfs:subClassOf obo:MPATH_62 .
obo:MPATH_235 a rdfs:Class ;
rdfs:label "blood vessel tumor" ;
rdfs:comment "Tumor of venous or arterial vessels or capillaries." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_476 a rdfs:Class ;
rdfs:label "telangiectasia" ;
rdfs:comment "A lesion formed by a dilated capillary or terminal artery." ;
rdfs:subClassOf obo:MPATH_474 .
obo:MPATH_192 a rdfs:Class ;
rdfs:label "type III hypersensitivity" ;
rdfs:comment "Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury." ;
rdfs:subClassOf obo:MPATH_189 .
obo:MPATH_199 a rdfs:Class ;
rdfs:label "immune mediated thrombocytopenia" ;
rdfs:comment "A condition resulting from an increased rate of immune mediated platelet destruction." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_285 a rdfs:Class ;
rdfs:label "intraductal papilloma" ;
rdfs:comment "Benign papilloma arising from ductal epithelium (M- 8503/0 )." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_445 .
a rdf:Property ;
rdfs:label "part of" ;
rdfs:range .
obo:MPATH_58 a rdfs:Class ;
rdfs:label "aplasia" ;
rdfs:comment "Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_134 a rdfs:Class ;
rdfs:label "hyperplasia" ;
rdfs:comment "An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_98 a rdfs:Class ;
rdfs:label "lymphangiectasis" ;
rdfs:comment "A stretching and widening of the lymphatic vessels." ;
rdfs:subClassOf obo:MPATH_474 , obo:MPATH_89 .
obo:MPATH_465 a rdfs:Class ;
rdfs:label "glaucoma developmental" ;
rdfs:comment "Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle." ;
rdfs:subClassOf obo:MPATH_32 .
obo:MPATH_888 a rdfs:Class ;
rdfs:label "onychogryphosis" ;
rdfs:comment "Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails." ;
rdfs:subClassOf obo:MPATH_631 .
obo:MPATH_810 a rdfs:Class ;
rdfs:label "follicular dystrophy" ;
rdfs:comment "Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture." ;
rdfs:subClassOf obo:MPATH_554 .
obo:MPATH_658 a rdfs:Class ;
rdfs:label "foreign body rhinitis" ;
rdfs:subClassOf obo:MPATH_657 .
obo:MPATH_108 a rdfs:Class ;
rdfs:label "disseminated intravascular coagulation" ;
rdfs:comment "A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products." ;
rdfs:subClassOf obo:MPATH_105 .
obo:MPATH_312 a rdfs:Class ;
rdfs:label "dysgerminoma" ;
rdfs:comment "Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3)." ;
rdfs:subClassOf obo:MPATH_310 .
obo:MPATH_304 a rdfs:Class ;
rdfs:label "serous adenocarcinoma" ;
rdfs:comment "Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_386 a rdfs:Class ;
rdfs:label "odontogenic tumor" ;
rdfs:comment "redundant" .
obo:MPATH_210 a rdfs:Class ;
rdfs:label "acquired immunodeficiency" ;
rdfs:comment "Defect in the immune system subsequent to external injury, infection or ablation." ;
rdfs:subClassOf obo:MPATH_209 .
obo:MPATH_4 a rdfs:Class ;
rdfs:label "necrosis" ;
rdfs:comment "Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3." ;
rdfs:subClassOf obo:MPATH_2 .
obo:MPATH_636 a rdfs:Class ;
rdfs:label "steatitis" ;
rdfs:comment "Inflammation of fatty tissue." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_517 a rdfs:Class ;
rdfs:label "precursor B cell neoplasms" ;
rdfs:comment "Lymphoma originating from precursor B-cells." ;
rdfs:subClassOf obo:MPATH_516 .
obo:MPATH_336 a rdfs:Class ;
rdfs:label "leukaemia" ;
rdfs:comment "obsolete folowing reclassification." .
obo:MPATH_449 a rdfs:Class ;
rdfs:label "verrucous carcinoma" ;
rdfs:comment "A well-differentiated papillary squamous cell carcinoma. (M-8051/3)." ;
rdfs:subClassOf obo:MPATH_442 , obo:MPATH_549 .
obo:MPATH_159 a rdfs:Class ;
rdfs:label "hypertrophy" ;
rdfs:comment "Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_278 a rdfs:Class ;
rdfs:label "follicular adenocarcinoma" ;
rdfs:comment "Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_353 a rdfs:Class ;
rdfs:label "hepatocellular adenoma" ;
rdfs:comment "Benign neoplasm derived from hepatocytes. (M- 8170/0)." ;
rdfs:subClassOf obo:MPATH_270 , obo:MPATH_352 .
obo:MPATH_808 a rdfs:Class ;
rdfs:label "lymphedema" ;
rdfs:comment "Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system." ;
rdfs:subClassOf obo:MPATH_109 .
obo:MPATH_267 a rdfs:Class ;
rdfs:label "glandular tumor" ;
rdfs:comment "Neoplasms derived from glandular epithelial cells." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_625 a rdfs:Class ;
rdfs:label "avulsion" ;
rdfs:comment "Tearing away or separation of two structures or parts." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_101 a rdfs:Class ;
rdfs:label "glycogen cell defect" ;
rdfs:comment "Lack of, displacement of, or abnormality in function or growth of the glycogen cells." ;
rdfs:subClassOf obo:MPATH_100 .
obo:MPATH_116 a rdfs:Class ;
rdfs:label "pulmonary embolism" ;
rdfs:comment "Occlusion of pulmonary vessels by an embolus." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_550 a rdfs:Class ;
rdfs:label "sarcoma" ;
rdfs:comment "A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells." .
obo:MPATH_381 a rdfs:Class ;
rdfs:label "ameloblastoma" ;
rdfs:comment "Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0)." ;
rdfs:subClassOf obo:MPATH_379 .
obo:MPATH_64 a rdfs:Class ;
rdfs:label "developmental dysplasia" ;
rdfs:comment "Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_188 a rdfs:Class ;
rdfs:label "immunopathological process" ;
rdfs:comment "Inappropriate or aberrant activation or suppression of the immune or inflammatory response." ;
rdfs:subClassOf obo:MPATH_596 .
obo:MPATH_498 a rdfs:Class ;
rdfs:label "myeloid leukaemia with maturation" ;
rdfs:comment "Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts." ;
rdfs:subClassOf obo:MPATH_342 .
obo:MPATH_724 a rdfs:Class ;
rdfs:label "xanthoma" ;
rdfs:comment "Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol." ;
rdfs:subClassOf obo:MPATH_42 .
obo:MPATH_408 a rdfs:Class ;
rdfs:label "soft tissue fibrosarcoma" ;
rdfs:comment "Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3)." ;
rdfs:subClassOf obo:MPATH_404 , obo:MPATH_551 .
obo:MPATH_92 a rdfs:Class ;
rdfs:label "cardiac defect" ;
rdfs:comment "Structural, organisational or growth related defects in cardiac development." ;
rdfs:subClassOf obo:MPATH_89 .
obo:MPATH_181 a rdfs:Class ;
rdfs:label "fibrosis" ;
rdfs:comment "Reactive formation of fibrous tissue." ;
rdfs:subClassOf obo:MPATH_176 .
obo:MPATH_730 a rdfs:Class ;
rdfs:label "renal tubular concretion" ;
rdfs:subClassOf obo:MPATH_614 .
obo:MPATH_651 a rdfs:Class ;
rdfs:label "ventral glossitis" ;
rdfs:subClassOf obo:MPATH_611 .
obo:MPATH_803 a rdfs:Class ;
rdfs:label "trabecular bone thickening" ;
rdfs:comment "Thickening of trabecular bone." ;
rdfs:subClassOf obo:MPATH_126 .
obo:MPATH_123 a rdfs:Class ;
rdfs:label "purpura" ;
rdfs:comment "Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia." ;
rdfs:subClassOf obo:MPATH_119 .
obo:MPATH_148 a rdfs:Class ;
rdfs:label "mesothelial hyperplasia" ;
rdfs:comment "Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_754 a rdfs:Class ;
rdfs:label "splenic hemosiderosis" ;
rdfs:comment "Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue." ;
rdfs:subClassOf obo:MPATH_726 .
obo:MPATH_599 a rdfs:Class ;
rdfs:label "developmental process abnormalities" ;
rdfs:subClassOf obo:MPATH_596 .
obo:MPATH_506 a rdfs:Class ;
rdfs:label "histiocytic sarcoma" ;
rdfs:comment "Solid tumor mass composed predominantly of histiocytic cells (M-9775/3)." ;
rdfs:subClassOf obo:MPATH_504 .
obo:MPATH_588 a rdfs:Class ;
rdfs:label "dysplasia" ;
rdfs:comment "Dysplasia" .
obo:MPATH_289 a rdfs:Class ;
rdfs:label "lobular carcinoma" ;
rdfs:comment "A form of breast adenocarcinoma derived from lobular cells. (M-8520/3)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_127 a rdfs:Class ;
rdfs:label "atrophy" ;
rdfs:comment "A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_438 a rdfs:Class ;
rdfs:label "schwannoma" ;
rdfs:comment "May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0)." ;
rdfs:subClassOf obo:MPATH_433 .
obo:MPATH_297 a rdfs:Class ;
rdfs:label "papillary cystadenocarcinoma" ;
rdfs:comment "A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3)." ;
rdfs:subClassOf obo:MPATH_276 .
obo:MPATH_743 a rdfs:Class ;
rdfs:label "hepatic centrolobular fatty metamorphosis" ;
rdfs:comment "Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins." ;
rdfs:subClassOf obo:MPATH_622 .
obo:MPATH_138 a rdfs:Class ;
rdfs:label "epithelial hyperplasia" ;
rdfs:comment "Abnormal proliferation of epithelial cells and epithelial components." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_697 a rdfs:Class ;
rdfs:label "alopecia areata" ;
rdfs:subClassOf obo:MPATH_26 .
obo:MPATH_483 a rdfs:Class ;
rdfs:label "atypical hyperplasia" ;
rdfs:comment "Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma." .
obo:MPATH_877 a rdfs:Class ;
rdfs:label "pneumonia" ;
rdfs:comment "An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_246 a rdfs:Class ;
rdfs:label "choroid plexus papilloma" ;
rdfs:comment "Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0)." ;
rdfs:subClassOf obo:MPATH_264 , obo:MPATH_565 .
obo:MPATH_178 a rdfs:Class ;
rdfs:label "extracellular matrix deposition" ;
rdfs:comment "Abnormal deposition of extracellular matrix proteins or other components." ;
rdfs:subClassOf obo:MPATH_176 .
obo:MPATH_788 a rdfs:Class ;
rdfs:label "testicular torsion" ;
rdfs:comment "The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle." ;
rdfs:subClassOf obo:MPATH_562 .
obo:MPATH_859 a rdfs:Class ;
rdfs:label "botryomycosis" ;
rdfs:comment "Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus." ;
rdfs:subClassOf obo:MPATH_627 .
obo:MPATH_209 a rdfs:Class ;
rdfs:label "secondary immunodeficiency disease" ;
rdfs:comment "Defect in the immune system subsequent to external injury, infection, ablation or deficiency." ;
rdfs:subClassOf obo:MPATH_202 .
obo:MPATH_814 a rdfs:Class ;
rdfs:label "focal hepatic lipidosis" ;
rdfs:comment "Locally circumscribed regions of fatty change." ;
rdfs:subClassOf obo:MPATH_622 .
obo:MPATH_535 a rdfs:Class ;
rdfs:label "T-cell neoplasms" ;
rdfs:comment "Neoplasms derived from cells of the T lymphocyte lineage." ;
rdfs:subClassOf obo:MPATH_513 .
obo:MPATH_601 a rdfs:Class ;
rdfs:label "developmental hypertrophy" ;
rdfs:comment "Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_81 a rdfs:Class ;
rdfs:label "perforation" ;
rdfs:comment "Presence of a hole/channel through a normally imperforate structure often a membrane or septum." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_647 a rdfs:Class ;
rdfs:label "interstitial nephritis" ;
rdfs:subClassOf obo:MPATH_212 , obo:MPATH_676 .
obo:MPATH_459 a rdfs:Class ;
rdfs:label "obsolete" .
obo:MPATH_18 a rdfs:Class ;
rdfs:label "cytoskeletal defect" ;
rdfs:comment "Defect in the structure or function of the cytoskeleton." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_528 a rdfs:Class ;
rdfs:label "classic Burkitt lymphoma" ;
rdfs:comment "Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells." ;
rdfs:subClassOf obo:MPATH_519 .
obo:MPATH_602 a rdfs:Class ;
rdfs:label "hyperplastic tissue" ;
rdfs:comment "An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation." ;
rdfs:subClassOf obo:MPATH_126 .
obo:MPATH_472 a rdfs:Class ;
rdfs:label "dorsal/ventral axis defect" ;
rdfs:comment "Dorsoventral aberration of the normal symmetrical organisation of the body pattern." ;
rdfs:subClassOf obo:MPATH_469 .
obo:MPATH_532 a rdfs:Class ;
rdfs:label "plasmacytoma" ;
rdfs:comment "Diffuse proliferation of mature plasma cells. Clonal by definition." ;
rdfs:subClassOf obo:MPATH_530 .
obo:MPATH_799 a rdfs:Class ;
rdfs:label "scoliosis" ;
rdfs:comment "scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways." ;
rdfs:subClassOf obo:MPATH_871 .
obo:MPATH_206 a rdfs:Class ;
rdfs:label "primary immunodeficiency disease" ;
rdfs:comment "Disease due to primary molecular or cellular defect in the immune system or its development." ;
rdfs:subClassOf obo:MPATH_202 .
obo:MPATH_86 a rdfs:Class ;
rdfs:label "organ specific developmental defect" ;
rdfs:comment "Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations." ;
rdfs:subClassOf obo:MPATH_55 .
obo:MPATH_427 a rdfs:Class ;
rdfs:label "myoblastoma" ;
rdfs:comment "obsolete. Syn of granular cell tumor. MPATH 413" .
obo:MPATH_513 a rdfs:Class ;
rdfs:label "lymphoid neoplasms" ;
rdfs:comment "Neoplasms of the B or T cell lineage." ;
rdfs:subClassOf obo:MPATH_335 .
obo:MPATH_405 a rdfs:Class ;
rdfs:label "chordoma" ;
rdfs:comment "Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3)." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_815 a rdfs:Class ;
rdfs:label "macrovesicular lipidosis" ;
rdfs:comment "subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery," ;
rdfs:subClassOf obo:MPATH_622 .
obo:MPATH_119 a rdfs:Class ;
rdfs:label "hemorrhage and non-specified extravasation" ;
rdfs:comment "Abnormal release of whole blood or the cellular component from the circulation." ;
rdfs:subClassOf obo:MPATH_105 .
obo:MPATH_461 a rdfs:Class ;
rdfs:label "cataract; capsular-epithelial" ;
rdfs:comment "Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin." ;
rdfs:subClassOf obo:MPATH_29 .
obo:MPATH_804 a rdfs:Class ;
rdfs:label "cavernous lymphangioma" ;
rdfs:comment "Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle." ;
rdfs:subClassOf obo:MPATH_420 .
obo:MPATH_836 a rdfs:Class ;
rdfs:label "dermal fibrosis" ;
rdfs:comment "fibrosis in the skin" ;
rdfs:subClassOf obo:MPATH_181 .
obo:MPATH_866 a rdfs:Class ;
rdfs:label "gastric adenomatous hyperplasia" ;
rdfs:comment "Thickening of the glandular epithelium" ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_708 a rdfs:Class ;
rdfs:label "pyelectasia" ;
rdfs:comment "Distension of the renal pelvis by accumulated fluid or urine." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_274 a rdfs:Class ;
rdfs:label "clear cell adenocarcinoma" ;
rdfs:comment "An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_561 a rdfs:Class ;
rdfs:label "adenosquamous carcinoma" ;
rdfs:comment "Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3." ;
rdfs:subClassOf obo:MPATH_268 , obo:MPATH_442 .
obo:MPATH_224 a rdfs:Class ;
rdfs:label "clear cell hidradenoma" ;
rdfs:comment "Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 )." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_263 a rdfs:Class ;
rdfs:label "rhabdoid sarcoma" ;
rdfs:comment "Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_551 .
obo:MPATH_765 a rdfs:Class ;
rdfs:label "fracture and healing" ;
rdfs:comment "Break in bone associated with exostoses." ;
rdfs:subClassOf obo:MPATH_764 .
obo:MPATH_239 a rdfs:Class ;
rdfs:label "hemangioendothelioma" ;
rdfs:comment "obsolete Use Hemangioma MPATH: 240" .
obo:MPATH_112 a rdfs:Class ;
rdfs:label "amniotic fluid embolism" ;
rdfs:comment "Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_629 a rdfs:Class ;
rdfs:label "cavernous hemangioma" ;
rdfs:comment "Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution." ;
rdfs:subClassOf obo:MPATH_240 .
obo:MPATH_774 a rdfs:Class ;
rdfs:label "focal hepatic coagulative necrosis" ;
rdfs:comment "Focal necrosis in the liver often but not always associated with thrombosis." ;
rdfs:subClassOf obo:MPATH_7 .
obo:MPATH_487 a rdfs:Class ;
rdfs:label "intestinal intra-epithelial neoplasia" ;
rdfs:comment "Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands." ;
rdfs:subClassOf obo:MPATH_128 .
obo:MPATH_326 a rdfs:Class ;
rdfs:label "granulosa cell tumor" ;
rdfs:comment ". Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1)." ;
rdfs:subClassOf obo:MPATH_323 .
obo:MPATH_713 a rdfs:Class ;
rdfs:label "situs ambiguus totalis" ;
rdfs:subClassOf obo:MPATH_720 .
obo:MPATH_75 a rdfs:Class ;
rdfs:label "hernia" ;
rdfs:comment "Protrusion of a loop or wall of an organ through an abnormal opening." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_502 a rdfs:Class ;
rdfs:label "monocytic leukaemia" ;
rdfs:comment "Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts." ;
rdfs:subClassOf obo:MPATH_342 .
obo:MPATH_166 a rdfs:Class ;
rdfs:label "goblet cell metaplasia" ;
rdfs:comment "Metaplasia resulting in formation of mucus secreting goblet cells." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_370 a rdfs:Class ;
rdfs:label "primitive neurectodermal tumor" ;
rdfs:comment "Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3)." ;
rdfs:subClassOf obo:MPATH_373 , obo:MPATH_570 .
obo:MPATH_725 a rdfs:Class ;
rdfs:label "chronic interstitial nephritis" ;
rdfs:subClassOf obo:MPATH_647 .
obo:MPATH_787 a rdfs:Class ;
rdfs:label "intervertebral disk prolapse ventral" ;
rdfs:comment "Ventral prolapse of the intervertebral disk." ;
rdfs:subClassOf obo:MPATH_742 .
obo:MPATH_318 a rdfs:Class ;
rdfs:label "classical seminoma" ;
rdfs:comment "As MPATH:317, but not spermatocytic (M-9061/3)." ;
rdfs:subClassOf obo:MPATH_317 .
obo:MPATH_643 a rdfs:Class ;
rdfs:label "serous exudate" ;
rdfs:comment "Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation." ;
rdfs:subClassOf obo:MPATH_106 .
obo:MPATH_684 a rdfs:Class ;
rdfs:label "arthropathy" ;
rdfs:subClassOf obo:MPATH_25 , obo:MPATH_655 .
obo:MPATH_323 a rdfs:Class ;
rdfs:label "gonadal somatic cell tumor" ;
rdfs:comment "Neoplasms derived from the non-germ cell derived tissues of the testis and ovary." ;
rdfs:subClassOf obo:MPATH_309 .
obo:MPATH_59 a rdfs:Class ;
rdfs:label "defective branching morphogenesis" ;
rdfs:comment "Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_826 a rdfs:Class ;
rdfs:label "granulomatous dermatitis" ;
rdfs:comment "granulomatous inflammation of the skin" ;
rdfs:subClassOf obo:MPATH_215 .
obo:MPATH_539 a rdfs:Class ;
rdfs:label "small T-cell lymphoma" ;
rdfs:comment "Accumulation of small mature T cells. No human counterpart known to date." ;
rdfs:subClassOf obo:MPATH_538 .
obo:MPATH_692 a rdfs:Class ;
rdfs:label "ulcerative blepharitis" ;
rdfs:subClassOf obo:MPATH_546 .
obo:MPATH_70 a rdfs:Class ;
rdfs:label "fistula" ;
rdfs:comment "An abnormal passage between two internal organs or leading from a cavity to the body surface." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_252 a rdfs:Class ;
rdfs:label "oligodendroglioma" ;
rdfs:comment "Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3)." ;
rdfs:subClassOf obo:MPATH_249 .
obo:MPATH_329 a rdfs:Class ;
rdfs:label "luteal cell tumor" ;
rdfs:comment "Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0)." ;
rdfs:subClassOf obo:MPATH_323 .
obo:MPATH_825 a rdfs:Class ;
rdfs:label "vacuolation" ;
rdfs:comment "Generation of intracytoplasmic vacuoles otherwise unspecified." ;
rdfs:subClassOf obo:MPATH_15 .
obo:MPATH_126 a rdfs:Class ;
rdfs:label "growth and differentiation defect" ;
rdfs:comment "Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs." ;
rdfs:subClassOf obo:MPATH_603 .
obo:MPATH_702 a rdfs:Class ;
rdfs:label "acquired aspermia" ;
rdfs:subClassOf obo:MPATH_796 .
obo:MPATH_557 a rdfs:Class ;
rdfs:label "aberrant crypt foci" ;
rdfs:comment "Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis." .
obo:MPATH_662 a rdfs:Class ;
rdfs:label "foreign body glossitis" ;
rdfs:subClassOf obo:MPATH_611 .
obo:MPATH_441 a rdfs:Class ;
rdfs:label "synovioma" ;
rdfs:comment "Obsolete. Use MPATH:440" .
obo:MPATH_268 a rdfs:Class ;
rdfs:label "adenocarcinoma" ;
rdfs:comment "Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_785 a rdfs:Class ;
rdfs:label "bone marrow granulopoiesis" ;
rdfs:comment "Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response." ;
rdfs:subClassOf obo:MPATH_188 .
obo:MPATH_39 a rdfs:Class ;
rdfs:label "glycogen deposition" ;
rdfs:comment "Intracellular deposition of glycogen." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_455 a rdfs:Class ;
rdfs:label "choriocarcinoma" ;
rdfs:comment "Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3)." ;
rdfs:subClassOf obo:MPATH_310 , obo:MPATH_454 .
obo:MPATH_364 a rdfs:Class ;
rdfs:label "mesothelial tumor" ;
rdfs:comment "obsolete; subsumed into MPATH365" .
obo:MPATH_546 a rdfs:Class ;
rdfs:label "blepharitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_777 a rdfs:Class ;
rdfs:label "urelithiasis" ;
rdfs:comment "Formation of urinary concretions in any part of the kidney." ;
rdfs:subClassOf obo:MPATH_614 .
obo:MPATH_703 a rdfs:Class ;
rdfs:label "developmental hypoplasia" ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_832 a rdfs:Class ;
rdfs:label "paraphimosis" ;
rdfs:comment "persistent retraction of the prepuce behind the glans penis" ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_379 a rdfs:Class ;
rdfs:label "odontogenic tumor" ;
rdfs:comment "Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) ." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_230 a rdfs:Class ;
rdfs:label "sebaceous adenoma" ;
rdfs:comment "Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_881 a rdfs:Class ;
rdfs:label "reactive fibrosis" ;
rdfs:comment "Fibrotic reaction to presence of a foreign body." ;
rdfs:subClassOf obo:MPATH_181 .
obo:MPATH_848 a rdfs:Class ;
rdfs:label "effacing granuloma" ;
rdfs:comment "Replacement of normal tissue by granuloma." ;
rdfs:subClassOf obo:MPATH_847 .
obo:MPATH_161 a rdfs:Class ;
rdfs:label "cartilaginous metaplasia" ;
rdfs:comment "Metaplasia resulting in heterotopic formation of cartilage." ;
rdfs:subClassOf obo:MPATH_605 .
obo:MPATH_589 a rdfs:Class ;
rdfs:label "dysplasia" ;
rdfs:comment "Distortion or deficiency of the tissue or cellular architecture." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_718 a rdfs:Class ;
rdfs:label "pre-sacral teratoma" ;
rdfs:comment "Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine." ;
rdfs:subClassOf obo:MPATH_322 .
obo:MPATH_79 a rdfs:Class ;
rdfs:label "malposition" ;
rdfs:comment "Abnormal position or orientation of a structure insufficient to be called a heterotopia." ;
rdfs:subClassOf obo:MPATH_76 .
obo:MPATH_416 a rdfs:Class ;
rdfs:label "angiomyolipoma" ;
rdfs:comment "Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_415 .
obo:MPATH_149 a rdfs:Class ;
rdfs:label "squamous hyperplasia" ;
rdfs:comment "Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia)." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_843 a rdfs:Class ;
rdfs:label "stasis" ;
rdfs:comment "Cessation of movement of a body fluid or liquid." ;
rdfs:subClassOf obo:MPATH_80 .
obo:MPATH_617 a rdfs:Class ;
rdfs:label "focus of cellular alteration" ;
rdfs:comment "Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type." ;
rdfs:subClassOf obo:MPATH_556 .
obo:MPATH_339 a rdfs:Class ;
rdfs:label "lymphatic leukaemia" .
obo:MPATH_759 a rdfs:Class ;
rdfs:label "pseudocyesis" ;
rdfs:comment "Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant" ;
rdfs:subClassOf obo:MPATH_474 .
obo:MPATH_456 a rdfs:Class ;
rdfs:label "hydatidiform mole" ;
rdfs:comment "Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0)." ;
rdfs:subClassOf obo:MPATH_454 .
obo:MPATH_256 a rdfs:Class ;
rdfs:label "carcinosarcoma" ;
rdfs:comment "Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_549 , obo:MPATH_551 .
obo:MPATH_57 a rdfs:Class ;
rdfs:label "agenesis" ;
rdfs:comment "Failure of a tissue or organ to develop." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_870 a rdfs:Class ;
rdfs:label "junctional epidermolysis bullosa" ;
rdfs:comment "severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t" ;
rdfs:subClassOf obo:MPATH_813 .
obo:MPATH_568 a rdfs:Class ;
rdfs:label "mixed glioma" ;
rdfs:comment "Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3)." ;
rdfs:subClassOf obo:MPATH_249 , obo:MPATH_254 .
obo:MPATH_241 a rdfs:Class ;
rdfs:label "hemangiopericytoma" ;
rdfs:comment "A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3)." ;
rdfs:subClassOf obo:MPATH_235 .
obo:MPATH_520 a rdfs:Class ;
rdfs:label "small B-cell lymphoma" ;
rdfs:comment "Diffuse accumulation of small mature B-cells." ;
rdfs:subClassOf obo:MPATH_519 .
obo:MPATH_280 a rdfs:Class ;
rdfs:label "Harderian gland adenoma" ;
rdfs:comment "Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_10 a rdfs:Class ;
rdfs:label "gangrene" ;
rdfs:comment "Extensive necrosis from whatever cause, often following chronic ischemia." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_780 a rdfs:Class ;
rdfs:label "pseudoxanthoma elasticum" ;
rdfs:comment "Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers." ;
rdfs:subClassOf obo:MPATH_36 .
obo:MPATH_97 a rdfs:Class ;
rdfs:label "dissecting aneurysm" ;
rdfs:comment "Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima." ;
rdfs:subClassOf obo:MPATH_90 .
obo:MPATH_359 a rdfs:Class ;
rdfs:label "melanoma" ;
rdfs:comment "Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3)." ;
rdfs:subClassOf obo:MPATH_358 .
obo:MPATH_854 a rdfs:Class ;
rdfs:label "cutaneous plasmacytosis" ;
rdfs:comment "Plasmacytosis in the skin." ;
rdfs:subClassOf obo:MPATH_852 .
obo:MPATH_748 a rdfs:Class ;
rdfs:label "recanalised thrombus" ;
rdfs:comment "An old organized thrombus that has been recanalized to permit blood flow." ;
rdfs:subClassOf obo:MPATH_125 .
obo:MPATH_673 a rdfs:Class ;
rdfs:label "metritis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_137 a rdfs:Class ;
rdfs:label "fibroglandular hyperplasia" ;
rdfs:comment "Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma." ;
rdfs:subClassOf obo:MPATH_135 .
obo:MPATH_430 a rdfs:Class ;
rdfs:label "angiomyxoma" ;
rdfs:comment "Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1)." ;
rdfs:subClassOf obo:MPATH_429 .
obo:MPATH_150 a rdfs:Class ;
rdfs:label "acanthosis" ;
rdfs:comment "Hyperplasia of the Malpighian layer (prickle cell) of the epidermis." ;
rdfs:subClassOf obo:MPATH_149 .
obo:MPATH_821 a rdfs:Class ;
rdfs:label "hypoplastic tissue" ;
rdfs:comment "Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation." ;
rdfs:subClassOf obo:MPATH_126 .
obo:MPATH_729 a rdfs:Class ;
rdfs:label "splenic melanosis" ;
rdfs:subClassOf obo:MPATH_44 .
obo:MPATH_791 a rdfs:Class ;
rdfs:label "cartilagenous embolism" ;
rdfs:comment "Occlusion of a vessel by a piece of dissected cartilage." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_200 a rdfs:Class ;
rdfs:label "myositis" ;
rdfs:comment "Inflammation of a muscle." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_837 a rdfs:Class ;
rdfs:label "hepatic mid-zonal fatty metamorphosis" ;
rdfs:comment "Fatty change in the mid-zonal region of the liver." ;
rdfs:subClassOf obo:MPATH_622 .
obo:MPATH_796 a rdfs:Class ;
rdfs:label "aspermia" ;
rdfs:comment "Lack of sperm." ;
rdfs:subClassOf obo:MPATH_797 .
obo:MPATH_296 a rdfs:Class ;
rdfs:label "papillary adenoma" ;
rdfs:comment "A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_735 a rdfs:Class ;
rdfs:label "molar hypercementosis" ;
rdfs:comment "Thickening of the cementum layer of the molars." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_216 a rdfs:Class ;
rdfs:label "necrotic inflammation" ;
rdfs:comment "Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_342 a rdfs:Class ;
rdfs:label "myeloid leukaemia" ;
rdfs:comment "Leukaemias of the myeloid lineage." ;
rdfs:subClassOf obo:MPATH_496 .
obo:MPATH_195 a rdfs:Class ;
rdfs:label "arthritis" ;
rdfs:comment "Inflammation of a joint." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_43 a rdfs:Class ;
rdfs:label "lipofuscin deposition" ;
rdfs:comment "Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related." ;
rdfs:subClassOf obo:MPATH_613 .
obo:MPATH_375 a rdfs:Class ;
rdfs:label "ganglioneuroma" ;
rdfs:comment "A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0)." ;
rdfs:subClassOf obo:MPATH_570 .
obo:MPATH_494 a rdfs:Class ;
rdfs:label "autoimmune glomerulonephritis" ;
rdfs:comment "Glomerulonephritis caused by autoimmune attack on the glomerulus." ;
rdfs:subClassOf obo:MPATH_197 .
obo:MPATH_21 a rdfs:Class ;
rdfs:label "lysosomal defect" ;
rdfs:comment "Defect in the structure or function of the lysosomes." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_68 a rdfs:Class ;
rdfs:label "diverticulum" ;
rdfs:comment "A blind ended outpouching through the wall of a tubular organ or bounded cavity." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_669 a rdfs:Class ;
rdfs:label "foreign body tracheitis" ;
rdfs:subClassOf obo:MPATH_668 .
obo:MPATH_621 a rdfs:Class ;
rdfs:label "inter-ventricular septal defect" ;
rdfs:comment "Failure of the inter-ventricular septum to completely close between the left and right ventricles." ;
rdfs:subClassOf obo:MPATH_93 .
obo:MPATH_0 a rdfs:Class ;
rdfs:label "pathological entity" ;
rdfs:comment "Pathological structure or process" ;
rdfs:subClassOf obo:MPATH_1000 .
obo:MPATH_32 a rdfs:Class ;
rdfs:label "glaucoma" ;
rdfs:comment "Increase in the intraocular pressure." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_333 a rdfs:Class ;
rdfs:label "sex cord tumor" ;
rdfs:comment "obsolete: Use more specific terms: MPATH: 334, 331, 329, 326" .
obo:MPATH_214 a rdfs:Class ;
rdfs:label "chronic inflammation" ;
rdfs:comment "Chronic inflammatory condition characterised by infiltration of primarily lymphocytes." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_847 a rdfs:Class ;
rdfs:label "granuloma" ;
rdfs:comment "Collection of epithelioid macrophages into a nodule" ;
rdfs:subClassOf obo:MPATH_215 .
obo:MPATH_632 a rdfs:Class ;
rdfs:label "hepatocytomegaly" ;
rdfs:comment "Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume." ;
rdfs:subClassOf obo:MPATH_631 .
obo:MPATH_392 a rdfs:Class ;
rdfs:label "chondrosarcoma" ;
rdfs:comment "Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_155 a rdfs:Class ;
rdfs:label "orthokeratosis" ;
rdfs:comment "Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium." ;
rdfs:subClassOf obo:MPATH_154 .
obo:MPATH_172 a rdfs:Class ;
rdfs:label "transitional cell metaplasia" ;
rdfs:comment "Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_301 a rdfs:Class ;
rdfs:label "pineocytoma" ;
rdfs:comment "A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1)." ;
rdfs:subClassOf obo:MPATH_267 .
obo:MPATH_144 a rdfs:Class ;
rdfs:label "myoepithelial hyperplasia" ;
rdfs:comment "Benign proliferation of glandular myoepithelial cells." ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_714 a rdfs:Class ;
rdfs:label "situs inversus with levocardia" ;
rdfs:subClassOf obo:MPATH_720 .
obo:MPATH_115 a rdfs:Class ;
rdfs:label "fat embolism" ;
rdfs:comment "Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_332 a rdfs:Class ;
rdfs:label "sertoli-leydig cell tumor" ;
rdfs:comment "Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0)." ;
rdfs:subClassOf obo:MPATH_323 .
obo:MPATH_451 a rdfs:Class ;
rdfs:label "transitional cell carcinoma" ;
rdfs:comment "Malignant neoplasm of transitional cells (M-8120/3)." ;
rdfs:subClassOf obo:MPATH_450 , obo:MPATH_549 .
obo:MPATH_595 a rdfs:Class ;
rdfs:label "extramedullary hemopoiesis" ;
rdfs:comment "The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors." ;
rdfs:subClassOf obo:MPATH_515 .
obo:MPATH_612 a rdfs:Class ;
rdfs:label "Abscess" ;
rdfs:comment "A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation." .
obo:MPATH_104 a rdfs:Class ;
rdfs:label "spongiotrophoblast defect" ;
rdfs:comment "Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta." ;
rdfs:subClassOf obo:MPATH_100 .
obo:MPATH_613 a rdfs:Class ;
rdfs:label "pigmentation" ;
rdfs:comment "Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_584 a rdfs:Class ;
rdfs:label "myelofibrosis" ;
rdfs:comment "In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_452 a rdfs:Class ;
rdfs:label "transitional cell carcinoma in situ" ;
rdfs:comment "Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2)." ;
rdfs:subClassOf obo:MPATH_450 , obo:MPATH_556 .
obo:MPATH_385 a rdfs:Class ;
rdfs:label "dentinoma" ;
rdfs:comment "Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0)." ;
rdfs:subClassOf obo:MPATH_379 .
obo:MPATH_594 a rdfs:Class ;
rdfs:label "cystic hyperplasia" ;
rdfs:comment "Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium." ;
rdfs:subClassOf obo:MPATH_135 .
obo:MPATH_223 a rdfs:Class ;
rdfs:label "ceruminous adenoma" ;
rdfs:comment "Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_624 a rdfs:Class ;
rdfs:label "involution" ;
rdfs:comment "Turning in of the edges of a structure." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_657 a rdfs:Class ;
rdfs:label "rhinitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_551 a rdfs:Class ;
rdfs:label "sarcoma" ;
rdfs:comment "A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_65 a rdfs:Class ;
rdfs:label "developmental hypoplasia" ;
rdfs:comment "Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development." .
obo:MPATH_448 a rdfs:Class ;
rdfs:label "squamous cell papilloma" ;
rdfs:comment "A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_442 , obo:MPATH_445 .
obo:MPATH_527 a rdfs:Class ;
rdfs:label "primary mediastinal (thymic) diffuse large B cell lymphoma" ;
rdfs:comment "Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease." ;
rdfs:subClassOf obo:MPATH_523 .
obo:MPATH_623 a rdfs:Class ;
rdfs:label "synechia" ;
rdfs:comment "An adhesion, usually between the iris and the cornea or the lens capsule." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_262 a rdfs:Class ;
rdfs:label "pulmonary blastoma" ;
rdfs:comment "A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_245 a rdfs:Class ;
rdfs:label "choroid plexus carcinoma" ;
rdfs:comment "Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3)." ;
rdfs:subClassOf obo:MPATH_549 , obo:MPATH_565 .
obo:MPATH_606 a rdfs:Class ;
rdfs:label "neoplasia" ;
rdfs:comment "The pathological process that results in the formation and growth of a neoplasm." ;
rdfs:subClassOf obo:MPATH_596 .
obo:MPATH_737 a rdfs:Class ;
rdfs:label "retinal degeneration" ;
rdfs:comment "Usually rd6-outer retinal photoreceptor degeneration" ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_37 a rdfs:Class ;
rdfs:label "ceroid deposition" ;
rdfs:comment "Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin." ;
rdfs:subClassOf obo:MPATH_613 .
obo:MPATH_768 a rdfs:Class ;
rdfs:label "septic necrosis" ;
rdfs:comment "Necrosis associated with or caused by local bacterial infection." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_747 a rdfs:Class ;
rdfs:label "renal tubular amyloidosis" ;
rdfs:comment "Pink amorphous material (amyloid) deposited within the renal tubules." ;
rdfs:subClassOf obo:MPATH_34 .
obo:MPATH_42 a rdfs:Class ;
rdfs:label "lipid deposition" ;
rdfs:comment "Extra or intracellular deposition of lipid." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_31 a rdfs:Class ;
rdfs:label "emphysema" ;
rdfs:comment "Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_184 a rdfs:Class ;
rdfs:label "sclerosis" ;
rdfs:comment "Any pathological thickening or hardening of a tissue." ;
rdfs:subClassOf obo:MPATH_176 .
obo:MPATH_346 a rdfs:Class ;
rdfs:label "autoimmune mediated disease" ;
rdfs:subClassOf obo:MPATH_194 .
obo:MPATH_516 a rdfs:Class ;
rdfs:label "B-cell neoplasms" ;
rdfs:comment "Neoplasm of the B cell lymphoid lineage." ;
rdfs:subClassOf obo:MPATH_513 .
obo:MPATH_26 a rdfs:Class ;
rdfs:label "alopecia" ;
rdfs:comment "Absence of hair or loss of hair." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_779 a rdfs:Class ;
rdfs:label "uretolithiasis" ;
rdfs:comment "Formation or urinary concretions in the ureter." ;
rdfs:subClassOf obo:MPATH_777 .
obo:MPATH_841 a rdfs:Class ;
rdfs:label "anopthalmia" ;
rdfs:comment "Absence of eye." ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_610 a rdfs:Class ;
rdfs:label "angiectasia" ;
rdfs:comment "Dilatation of a blood vessel or valve." ;
rdfs:subClassOf obo:MPATH_474 .
obo:MPATH_240 a rdfs:Class ;
rdfs:label "hemangioma" ;
rdfs:comment "Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively)." ;
rdfs:subClassOf obo:MPATH_235 .
obo:MPATH_505 a rdfs:Class ;
rdfs:label "granulocytic sarcoma" ;
rdfs:comment "Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells." ;
rdfs:subClassOf obo:MPATH_504 .
obo:MPATH_348 a rdfs:Class ;
rdfs:label "thymic lymphoma" ;
rdfs:comment "obsolete" .
obo:MPATH_313 a rdfs:Class ;
rdfs:label "embryonal carcinoma" ;
rdfs:comment "Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 )." ;
rdfs:subClassOf obo:MPATH_310 , obo:MPATH_549 .
obo:MPATH_3 a rdfs:Class ;
rdfs:label "apoptosis" ;
rdfs:comment "Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies." ;
rdfs:subClassOf obo:MPATH_2 .
obo:MPATH_639 a rdfs:Class ;
rdfs:label "hydrocephalus" ;
rdfs:comment "Accumulation of water in the ventricles of the brain." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_753 a rdfs:Class ;
rdfs:label "gastric forestomach papillomatous hyperplasia" ;
rdfs:comment "The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks." ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_583 a rdfs:Class ;
rdfs:label "scarring alopecia" ;
rdfs:comment "Loss of hair follicles in a diffuse dermal scar." ;
rdfs:subClassOf obo:MPATH_26 .
obo:MPATH_645 a rdfs:Class ;
rdfs:label "epicarditis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_314 a rdfs:Class ;
rdfs:label "endodermal sinus tumor" ;
rdfs:comment "Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3)." ;
rdfs:subClassOf obo:MPATH_310 , obo:MPATH_549 .
obo:MPATH_816 a rdfs:Class ;
rdfs:label "microvesicular lipidosis" ;
rdfs:comment """Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to
the periphery in contrast to macrovesicular lipidosis.""" ;
rdfs:subClassOf obo:MPATH_622 .
obo:MPATH_91 a rdfs:Class ;
rdfs:label "arteriovenous anastomosis" ;
rdfs:comment "Formation of vessels between arterioles and venules bypassing capillary circulation." ;
rdfs:subClassOf obo:MPATH_89 .
obo:MPATH_497 a rdfs:Class ;
rdfs:label "myeloid leukaemia without maturation" ;
rdfs:comment "Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts." ;
rdfs:subClassOf obo:MPATH_342 .
obo:MPATH_565 a rdfs:Class ;
rdfs:label "tumors of neurepithelial tissue" ;
rdfs:comment "Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium." ;
rdfs:subClassOf obo:MPATH_243 .
obo:MPATH_460 a rdfs:Class ;
rdfs:label "nuclear defect" ;
rdfs:comment "Defect in the structure or function of the nuclear membrane or matrix or other component." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_458 a rdfs:Class ;
rdfs:label "normal" ;
rdfs:comment "No pathological entity observable." ;
rdfs:subClassOf obo:MPATH_1000 .
obo:MPATH_277 a rdfs:Class ;
rdfs:label "cystadenoma" ;
rdfs:comment "A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_746 a rdfs:Class ;
rdfs:label "cartilagenous erosion" ;
rdfs:comment "Fragmentation and erosion of articular cartilage." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_710 a rdfs:Class ;
rdfs:label "embryonal rhabdomyosarcoma" ;
rdfs:comment "Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle." ;
rdfs:subClassOf obo:MPATH_428 .
obo:MPATH_471 a rdfs:Class ;
rdfs:label "anterior/posterior axis defect" ;
rdfs:comment "Anteroposterior aberration of the normal symmetrical organisation of the body pattern." ;
rdfs:subClassOf obo:MPATH_469 .
obo:MPATH_865 a rdfs:Class ;
rdfs:label "foreign body acute papillomatous glossitis" ;
rdfs:comment "Papillomatous inflammation of the tongue caused by a foreign body." ;
rdfs:subClassOf obo:MPATH_662 .
obo:MPATH_352 a rdfs:Class ;
rdfs:label "hepatic tumor" ;
rdfs:comment "Tumors of the liver and biliary apparatus." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_707 a rdfs:Class ;
rdfs:label "angiolipoma" ;
rdfs:subClassOf obo:MPATH_415 .
obo:MPATH_634 a rdfs:Class ;
rdfs:label "furunculosis" ;
rdfs:comment "Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_543 a rdfs:Class ;
rdfs:label "cholangioma" ;
rdfs:comment "Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0)." ;
rdfs:subClassOf obo:MPATH_352 .
obo:MPATH_628 a rdfs:Class ;
rdfs:label "pyogenic granuloma" ;
rdfs:comment "A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion." ;
rdfs:subClassOf obo:MPATH_240 .
obo:MPATH_699 a rdfs:Class ;
rdfs:label "ankylosing exostosis" ;
rdfs:subClassOf obo:MPATH_698 .
obo:MPATH_404 a rdfs:Class ;
rdfs:label "soft tissue tumor" ;
rdfs:comment "Neoplasms of the soft and connective tissues." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_512 a rdfs:Class ;
rdfs:label "myeloproliferative disease" ;
rdfs:comment "Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow." ;
rdfs:subClassOf obo:MPATH_510 .
obo:MPATH_680 a rdfs:Class ;
rdfs:label "septic urocystitis" ;
rdfs:subClassOf obo:MPATH_679 .
obo:MPATH_437 a rdfs:Class ;
rdfs:label "neurofibrosarcoma" ;
rdfs:comment "Malignant neoplasm derived from Schwann cells. (M-9540/3)." ;
rdfs:subClassOf obo:MPATH_433 , obo:MPATH_551 .
obo:MPATH_169 a rdfs:Class ;
rdfs:label "nephrogenic metaplasia" ;
rdfs:comment ".A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_721 a rdfs:Class ;
rdfs:label "sacrococcygeal teratoma" ;
rdfs:comment "Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx." ;
rdfs:subClassOf obo:MPATH_322 .
obo:MPATH_158 a rdfs:Class ;
rdfs:label "seborrheic keratosis" ;
rdfs:comment "Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts." ;
rdfs:subClassOf obo:MPATH_149 .
obo:MPATH_775 a rdfs:Class ;
rdfs:label "compression" ;
rdfs:comment "Exertion of abnormal force on a structure or structures usually resulting in deformation and damage." ;
rdfs:subClassOf obo:MPATH_15 .
obo:MPATH_389 a rdfs:Class ;
rdfs:label "chondroblastoma" ;
rdfs:comment "A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_830 a rdfs:Class ;
rdfs:label "regeneration" ;
rdfs:comment "repair, reproduction, or replacement of lost or injured cells, tissues, or organs." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_860 a rdfs:Class ;
rdfs:label "cholecystitis" ;
rdfs:comment "inflammation of the gall bladder" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_420 a rdfs:Class ;
rdfs:label "lymphangioma" ;
rdfs:comment "Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0)." ;
rdfs:subClassOf obo:MPATH_419 , obo:MPATH_74 .
obo:MPATH_309 a rdfs:Class ;
rdfs:label "gonadal tumor" ;
rdfs:comment "Germ cell and non-germ cell tumors of the testis and ovary." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_24 a rdfs:Class ;
rdfs:label "plasma membrane defect" ;
rdfs:comment "Defect in the structure or function of the plasma membrane." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_482 a rdfs:Class ;
rdfs:label "focal hyperplasia" ;
rdfs:comment "Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_363 a rdfs:Class ;
rdfs:label "mesonephric tumor" ;
rdfs:comment "Tumor beleived to be derived from mesonephric remnants. (M-8310/3)." ;
rdfs:subClassOf obo:MPATH_362 .
obo:MPATH_598 a rdfs:Class ;
rdfs:label "degenerative entity" .
obo:MPATH_324 a rdfs:Class ;
rdfs:label "androblastoma" ;
rdfs:comment "obsolete use Sertoli cell tumor MPATH: 331." .
obo:MPATH_35 a rdfs:Class ;
rdfs:label "bile deposition" ;
rdfs:comment "Intra- or extracellular deposition of bile pigments and their metabolites." ;
rdfs:subClassOf obo:MPATH_613 .
obo:MPATH_303 a rdfs:Class ;
rdfs:label "pseudomyxoma peritonei" ;
rdfs:comment "Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6)." ;
rdfs:subClassOf obo:MPATH_267 .
obo:MPATH_46 a rdfs:Class ;
rdfs:label "uric acid deposition" ;
rdfs:comment "Extracellular deposition of uric acid crystals." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_66 a rdfs:Class ;
rdfs:label "dilatation" ;
rdfs:comment "Increase in the diameter of an orifice or tubular structure beyond its normal dimensions." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_764 a rdfs:Class ;
rdfs:label "fracture" ;
rdfs:comment "A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_540 a rdfs:Class ;
rdfs:label "T cell neoplasms character undetermined" ;
rdfs:comment "T cell neoplasms which cannot currently be classified into known subtypes." ;
rdfs:subClassOf obo:MPATH_535 .
obo:MPATH_805 a rdfs:Class ;
rdfs:label "cystic hygroma" ;
rdfs:comment "Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels." ;
rdfs:subClassOf obo:MPATH_420 .
obo:MPATH_822 a rdfs:Class ;
rdfs:label "hypoplastic gut associated lymphoid tissue" ;
rdfs:comment "Reduced mass of GALT resulting form fewer cells." ;
rdfs:subClassOf obo:MPATH_821 .
obo:MPATH_54 a rdfs:Class ;
rdfs:label "osteoporosis" ;
rdfs:comment "Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_781 a rdfs:Class ;
rdfs:label "encephalomalacia" ;
rdfs:comment "Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_690 a rdfs:Class ;
rdfs:label "phlebitis" ;
rdfs:subClassOf obo:MPATH_201 .
obo:MPATH_549 a rdfs:Class ;
rdfs:label "carcinoma" ;
rdfs:comment "Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma)." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_562 a rdfs:Class ;
rdfs:label "torsion" ;
rdfs:comment "The twisting of a bodily organ or part on its own axis." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_234 a rdfs:Class ;
rdfs:label "basal cell carcinoma" ;
rdfs:comment "Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3)." ;
rdfs:subClassOf obo:MPATH_549 , obo:MPATH_575 .
obo:MPATH_87 a rdfs:Class ;
rdfs:label "germ cell defect" ;
rdfs:comment "Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic." ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_80 a rdfs:Class ;
rdfs:label "obstruction and stenosis" ;
rdfs:comment "Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_554 a rdfs:Class ;
rdfs:label "dystrophy" ;
rdfs:comment "Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ." ;
rdfs:subClassOf obo:MPATH_14 .
obo:MPATH_757 a rdfs:Class ;
rdfs:label "interstitial mineralization" ;
rdfs:comment "Foci of mineralization within the interstitium of a tissue." ;
rdfs:subClassOf obo:MPATH_555 .
obo:MPATH_368 a rdfs:Class ;
rdfs:label "endocrine adenocarcinoma" ;
rdfs:comment "obsolete." .
obo:MPATH_147 a rdfs:Class ;
rdfs:label "lymphoid hyperplasia" ;
rdfs:comment "Benign enlargement of lymphoid tissues." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_871 a rdfs:Class ;
rdfs:label "spinal structural defects" ;
rdfs:comment "Structural defects of the bony and muscular components of the vertebrae." ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_76 a rdfs:Class ;
rdfs:label "heterotopia" ;
rdfs:comment "Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly)." ;
rdfs:subClassOf obo:MPATH_67 .
obo:MPATH_55 a rdfs:Class ;
rdfs:label "developmental and structural abnormality" ;
rdfs:comment "Developmental and structural abnormalities occurring during embryonic development or during adult life." ;
rdfs:subClassOf obo:MPATH_603 .
obo:MPATH_501 a rdfs:Class ;
rdfs:label "myelomonocytic leukaemia" ;
rdfs:comment "Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts." ;
rdfs:subClassOf obo:MPATH_342 .
obo:MPATH_426 a rdfs:Class ;
rdfs:label "leiomyosarcoma" ;
rdfs:comment "Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3)." ;
rdfs:subClassOf obo:MPATH_423 , obo:MPATH_551 .
obo:MPATH_208 a rdfs:Class ;
rdfs:label "immunodeficiency - myeloid/phagocytic defect" ;
rdfs:comment "Primary defect in the myeloid arm of the immune system." ;
rdfs:subClassOf obo:MPATH_206 .
obo:MPATH_95 a rdfs:Class ;
rdfs:label "hypertrophic ventricle" ;
rdfs:comment "Thickening of the wall of one or both of the heart ventricles." ;
rdfs:subClassOf obo:MPATH_92 .
obo:MPATH_534 a rdfs:Class ;
rdfs:label "anaplastic plasmacytoma" ;
rdfs:comment "Diffuse proliferation of immature plasma cells or plasma blasts." ;
rdfs:subClassOf obo:MPATH_532 .
obo:MPATH_587 a rdfs:Class ;
rdfs:label "Cribriform epididymal hyperplasia" ;
rdfs:comment "The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_357 a rdfs:Class ;
rdfs:label "hepatocellular carcinoma" ;
rdfs:comment "Malignant tumor derived from hepatocytes. (M- 8170/3)." ;
rdfs:subClassOf obo:MPATH_352 , obo:MPATH_549 .
obo:MPATH_442 a rdfs:Class ;
rdfs:label "squamous cell tumor" ;
rdfs:comment "Neoplasms of stratified squamous epithelial cells." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_273 a rdfs:Class ;
rdfs:label "bronchioloalveolar carcinoma" ;
rdfs:comment "Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification." ;
rdfs:subClassOf obo:MPATH_268 , obo:MPATH_549 .
obo:MPATH_646 a rdfs:Class ;
rdfs:label "chondroarthritis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_652 a rdfs:Class ;
rdfs:label "histiocytosis" ;
rdfs:comment "Benign proliferation of histiocytes." ;
rdfs:subClassOf obo:MPATH_194 , obo:MPATH_602 .
obo:MPATH_15 a rdfs:Class ;
rdfs:label "general degenerative process" ;
rdfs:comment "Change of tissue to a lower state of integrity or less functional form, as in heart failure." ;
rdfs:subClassOf obo:MPATH_14 .
obo:MPATH_431 a rdfs:Class ;
rdfs:label "myxoma" ;
rdfs:comment "A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0)." ;
rdfs:subClassOf obo:MPATH_429 .
obo:MPATH_603 a rdfs:Class ;
rdfs:label "pathological anatomical entity" ;
rdfs:comment "Anatomically located instance of pathological response or entity." ;
rdfs:subClassOf obo:MPATH_0 .
obo:MPATH_396 a rdfs:Class ;
rdfs:label "osteoma" ;
rdfs:comment "Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_13 a rdfs:Class ;
rdfs:label "piecemeal necrosis" ;
rdfs:comment "Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_807 a rdfs:Class ;
rdfs:label "hygroma" ;
rdfs:comment "Large cystic subcutaneous spaces usually found in the flexures, especially around the neck." ;
rdfs:subClassOf obo:MPATH_62 .
obo:MPATH_798 a rdfs:Class ;
rdfs:label "hypospermia" ;
rdfs:comment "Reduced numbers of sperm." ;
rdfs:subClassOf obo:MPATH_797 .
obo:MPATH_533 a rdfs:Class ;
rdfs:label "extraosseous plasmacytoma" ;
rdfs:comment "Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum." ;
rdfs:subClassOf obo:MPATH_532 .
obo:MPATH_20 a rdfs:Class ;
rdfs:label "golgi defect" ;
rdfs:comment "Defect in the structure or function of the golgi apparatus." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_284 a rdfs:Class ;
rdfs:label "intraductal papillary carcinoma" ;
rdfs:comment "Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_325 a rdfs:Class ;
rdfs:label "fibrothecoma" ;
rdfs:comment "obsolete use thecoma MPATH:334." .
obo:MPATH_882 a rdfs:Class ;
rdfs:label "hepatic peri-ductal inflammation" ;
rdfs:comment "Inflammatory cell infiltrate around bile ducts within the liver." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_571 a rdfs:Class ;
rdfs:label "pilomatricoma" ;
rdfs:comment "Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common." ;
rdfs:subClassOf obo:MPATH_575 .
obo:MPATH_776 a rdfs:Class ;
rdfs:label "spermatocoele" ;
rdfs:comment "A spermatocoele is a cyst that contains spermatozoa. ." ;
rdfs:subClassOf obo:MPATH_62 .
obo:MPATH_109 a rdfs:Class ;
rdfs:label "edema" ;
rdfs:comment "An accumulation of an excessive amount of watery fluid in cells or intercellular tissues." ;
rdfs:subClassOf obo:MPATH_106 .
obo:MPATH_618 a rdfs:Class ;
rdfs:label "myeloid hyperplasia" ;
rdfs:comment "Hyperplasia of myeloid lineage, usually in the spleen." ;
rdfs:subClassOf obo:MPATH_515 .
obo:MPATH_334 a rdfs:Class ;
rdfs:label "thecoma" ;
rdfs:comment "Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0)." ;
rdfs:subClassOf obo:MPATH_323 .
obo:MPATH_125 a rdfs:Class ;
rdfs:label "thrombosis" ;
rdfs:comment "Presence of an occluding or mural thrombus in a blood vessel." ;
rdfs:subClassOf obo:MPATH_105 .
obo:MPATH_567 a rdfs:Class ;
rdfs:label "pilocytic astrocytoma" ;
rdfs:comment "Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1)." ;
rdfs:subClassOf obo:MPATH_244 .
obo:MPATH_833 a rdfs:Class ;
rdfs:label "subacute inflammation" ;
rdfs:comment "transition between acute and chronic inflammation." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_849 a rdfs:Class ;
rdfs:label "anaplastic mammary adenocarcinoma" ;
rdfs:comment "poorly differentiated adenocarcinoma of the mammary gland" ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_678 a rdfs:Class ;
rdfs:label "septic nephritis" ;
rdfs:subClassOf obo:MPATH_676 .
obo:MPATH_486 a rdfs:Class ;
rdfs:label "ductal intra-epithelial neoplasia" ;
rdfs:comment "Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_556 .
obo:MPATH_151 a rdfs:Class ;
rdfs:label "actinic keratosis" ;
rdfs:comment "Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date." ;
rdfs:subClassOf obo:MPATH_149 , obo:MPATH_556 .
obo:MPATH_14 a rdfs:Class ;
rdfs:label "process of degenerative change" ;
rdfs:comment "A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell." ;
rdfs:subClassOf obo:MPATH_597 .
obo:MPATH_544 a rdfs:Class ;
rdfs:label "hepatocholangiocellular adenoma" ;
rdfs:comment "Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_270 , obo:MPATH_352 .
obo:MPATH_111 a rdfs:Class ;
rdfs:label "air embolism" ;
rdfs:comment "An bubble of air occluding flow through a blood or lymphatic vessel." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_165 a rdfs:Class ;
rdfs:label "glandular metaplasia" ;
rdfs:comment "Development of heterotopic glandular epithelia." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_763 a rdfs:Class ;
rdfs:label "sialocele" ;
rdfs:comment "Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure." ;
rdfs:subClassOf obo:MPATH_62 .
obo:MPATH_556 a rdfs:Class ;
rdfs:label "potentially cancerous lesions" ;
rdfs:comment "Lesions which in some cases have the potential to become progressively growing malignant tumors." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_374 a rdfs:Class ;
rdfs:label "esthesioneuroblastoma" ;
rdfs:comment "A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3)." ;
rdfs:subClassOf obo:MPATH_373 .
obo:MPATH_663 a rdfs:Class ;
rdfs:label "peritonitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_191 a rdfs:Class ;
rdfs:label "type II hypersensitivity" ;
rdfs:comment "Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues." ;
rdfs:subClassOf obo:MPATH_189 .
obo:MPATH_270 a rdfs:Class ;
rdfs:label "adenoma" ;
rdfs:comment "A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_556 .
obo:MPATH_792 a rdfs:Class ;
rdfs:label "lymph node reticuloendothelial cell hyperplasia" ;
rdfs:comment "Proliferation of the reticuloendothelial cells in the medulla of the lymph node." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_698 a rdfs:Class ;
rdfs:label "exostosis" ;
rdfs:subClassOf obo:MPATH_126 .
obo:MPATH_248 a rdfs:Class ;
rdfs:label "ependymoma malignant" ;
rdfs:comment "obsolete -subsumed into MPATH:247" .
obo:MPATH_704 a rdfs:Class ;
rdfs:label "thyroiditis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_140 a rdfs:Class ;
rdfs:label "hyperplastic polyp" ;
rdfs:comment "A benign polyp, usually in the colon, showing hyperplasia." ;
rdfs:subClassOf obo:MPATH_491 .
obo:MPATH_99 a rdfs:Class ;
rdfs:label "varices" ;
rdfs:comment "An enlarged and often tortuous vein." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_770 a rdfs:Class ;
rdfs:label "abnormal organ size" ;
rdfs:comment "Abnormal organ dimensions or weight" ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_189 a rdfs:Class ;
rdfs:label "hypersensitivity disease" ;
rdfs:comment "Immune response resulting in tissue injury." ;
rdfs:subClassOf obo:MPATH_188 .
obo:MPATH_786 a rdfs:Class ;
rdfs:label "inspissation" ;
rdfs:comment "The drying, thickening and coagulation of extracellular secretions or fluids." ;
rdfs:subClassOf obo:MPATH_15 .
obo:MPATH_19 a rdfs:Class ;
rdfs:label "endoplasmic reticulum defect" ;
rdfs:comment "Defect in the structure or function of the endoplasmic reticulum." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_349 a rdfs:Class ;
rdfs:label "mast cell tumor" ;
rdfs:comment "obsolete; see MPATH507" .
obo:MPATH_468 a rdfs:Class ;
rdfs:label "pseudocyst" ;
rdfs:comment "Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_769 a rdfs:Class ;
rdfs:label "uterine septic necrosis" ;
rdfs:comment "Necrosis of the uterine wall with large bacterial colonies on its surface." ;
rdfs:subClassOf obo:MPATH_768 .
obo:MPATH_479 a rdfs:Class ;
rdfs:label "vasculogenesis defect" ;
rdfs:comment "Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_538 a rdfs:Class ;
rdfs:label "mature T-cell neoplasms" ;
rdfs:comment "Non-thymic neoplasms of mature T cell origin." ;
rdfs:subClassOf obo:MPATH_535 .
obo:MPATH_685 a rdfs:Class ;
rdfs:label "accessory organ" ;
rdfs:subClassOf obo:MPATH_84 .
obo:MPATH_545 a rdfs:Class ;
rdfs:label "hepatocholangiocellular carcinoma" ;
rdfs:comment "Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_352 , obo:MPATH_549 .
obo:MPATH_811 a rdfs:Class ;
rdfs:label "epicardial mineralization" ;
rdfs:comment "Deposition of minerals in the epicardium." ;
rdfs:subClassOf obo:MPATH_555 .
obo:MPATH_177 a rdfs:Class ;
rdfs:label "angiogenesis" ;
rdfs:comment "Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis." ;
rdfs:subClassOf obo:MPATH_176 .
obo:MPATH_100 a rdfs:Class ;
rdfs:label "placental abnormality" ;
rdfs:comment "Defect in placental growth, differentiation of circulation; maternal or embryonic component." ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_827 a rdfs:Class ;
rdfs:label "chronic dermatitis" ;
rdfs:comment "chronic inflammation of the skin" ;
rdfs:subClassOf obo:MPATH_214 .
obo:MPATH_136 a rdfs:Class ;
rdfs:label "fibroepithelial polyp" ;
rdfs:comment "A polypoid outgrowth of both epidermis and dermal fibrovascular tissue." ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_679 a rdfs:Class ;
rdfs:label "urocystitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_510 a rdfs:Class ;
rdfs:label "myeloid proliferations (non-reactive)" ;
rdfs:comment "Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined." ;
rdfs:subClassOf obo:MPATH_515 .
obo:MPATH_800 a rdfs:Class ;
rdfs:label "intervertebral disk prolapse dorsal" ;
rdfs:comment "Dorsal prolapse of the intervertebral disk." ;
rdfs:subClassOf obo:MPATH_742 .
obo:MPATH_475 a rdfs:Class ;
rdfs:label "ductal ectasia" ;
rdfs:comment "Dilation of a ductal structure." ;
rdfs:subClassOf obo:MPATH_474 .
obo:MPATH_237 a rdfs:Class ;
rdfs:label "angiokeratoma" ;
rdfs:comment "An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0)." ;
rdfs:subClassOf obo:MPATH_235 .
obo:MPATH_6 a rdfs:Class ;
rdfs:label "caseous necrosis" ;
rdfs:comment "Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_838 a rdfs:Class ;
rdfs:label "anaplastic carcinoma" ;
rdfs:comment "carcinoma with an absence of epithelial structural differentiation." ;
rdfs:subClassOf obo:MPATH_549 .
obo:MPATH_341 a rdfs:Class ;
rdfs:label "myelodysplastic disorder" ;
rdfs:comment "Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts." ;
rdfs:subClassOf obo:MPATH_508 .
obo:MPATH_614 a rdfs:Class ;
rdfs:label "concretion" ;
rdfs:comment "Solid material formed by aggregation of discrete units or particles." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_25 a rdfs:Class ;
rdfs:label "tissue specific degenerative process" ;
rdfs:comment "Degenerative process characteristic of a particular tissue." ;
rdfs:subClassOf obo:MPATH_14 .
obo:MPATH_371 a rdfs:Class ;
rdfs:label "small cell carcinoma" ;
rdfs:comment "Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification." ;
rdfs:subClassOf obo:MPATH_366 , obo:MPATH_549 .
obo:MPATH_819 a rdfs:Class ;
rdfs:label "focal renal pelvic mineralisation." ;
rdfs:subClassOf obo:MPATH_555 .
obo:MPATH_726 a rdfs:Class ;
rdfs:label "hemosiderosis" ;
rdfs:subClassOf obo:MPATH_41 .
obo:MPATH_180 a rdfs:Class ;
rdfs:label "fibroblast proliferation" ;
rdfs:comment "Abnormal or reactive proliferation of fibroblasts." ;
rdfs:subClassOf obo:MPATH_176 .
obo:MPATH_69 a rdfs:Class ;
rdfs:label "ectopia" ;
rdfs:comment "obsolete - Subsumed into heterotopia MPATH:76" .
obo:MPATH_162 a rdfs:Class ;
rdfs:label "epithelial metaplasia" ;
rdfs:comment "Metaplasia occurring within epithelia." ;
rdfs:subClassOf obo:MPATH_605 .
obo:MPATH_575 a rdfs:Class ;
rdfs:label "basaloid follicular neoplasms" ;
rdfs:comment "This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation." ;
rdfs:subClassOf obo:MPATH_219 .
obo:MPATH_715 a rdfs:Class ;
rdfs:label "sinusitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_122 a rdfs:Class ;
rdfs:label "petechia" ;
rdfs:comment "Small hemorrhagic spots in the skin caused by blood vessel breakdown." ;
rdfs:subClassOf obo:MPATH_119 .
obo:MPATH_668 a rdfs:Class ;
rdfs:label "tracheitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_732 a rdfs:Class ;
rdfs:label "tracheal gland ectasia" ;
rdfs:subClassOf obo:MPATH_474 .
obo:MPATH_674 a rdfs:Class ;
rdfs:label "osteomyelitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_382 a rdfs:Class ;
rdfs:label "cementifying fibroma" ;
rdfs:comment "Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0)." ;
rdfs:subClassOf obo:MPATH_379 .
obo:MPATH_570 a rdfs:Class ;
rdfs:label "peripheral nervous system tumors" ;
rdfs:comment "Tumors of the peripheral nervous system." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_281 a rdfs:Class ;
rdfs:label "Harderian gland carcinoma" ;
rdfs:comment "Malignant tumor derived form acinar epithelium of the Harderian gland." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_251 a rdfs:Class ;
rdfs:label "meningioma" ;
rdfs:comment "Benign or malignant neoplasm derived from the meninges. (M-9530/0)." ;
rdfs:subClassOf obo:MPATH_566 .
obo:MPATH_609 a rdfs:Class ;
rdfs:label "empyema" ;
rdfs:comment "Pus in a body cavity; when used without qualification, refers specifically to pyothorax." ;
rdfs:subClassOf obo:MPATH_607 .
obo:MPATH_590 a rdfs:Class ;
rdfs:label "fibro-osseous lesion" ;
rdfs:comment "Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts." ;
rdfs:subClassOf obo:MPATH_589 .
obo:MPATH_640 a rdfs:Class ;
rdfs:label "osteoid deposition" ;
rdfs:comment "Deposition of organic bone matrix." ;
rdfs:subClassOf obo:MPATH_178 .
obo:MPATH_509 a rdfs:Class ;
rdfs:label "cytopenia with increased blasts" ;
rdfs:comment "Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts." ;
rdfs:subClassOf obo:MPATH_508 .
obo:MPATH_226 a rdfs:Class ;
rdfs:label "eccrine gland adenoma" ;
rdfs:comment "Benign neoplasm of the eccrine gland (M-8408/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_523 a rdfs:Class ;
rdfs:label "diffuse large B-cell lymphoma" ;
rdfs:comment "Diffuse proliferation of large B lymphoid cells." ;
rdfs:subClassOf obo:MPATH_519 .
obo:MPATH_415 a rdfs:Class ;
rdfs:label "lipomatous tumor" ;
rdfs:comment "Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_694 a rdfs:Class ;
rdfs:label "acidophilic anterior pituitary gland adenoma" ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_855 a rdfs:Class ;
rdfs:label "Splendore-Hoeppli phenomenon" ;
rdfs:comment "In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances." ;
rdfs:subClassOf obo:MPATH_194 .
obo:MPATH_797 a rdfs:Class ;
rdfs:label "spermatogenesis defect" ;
rdfs:comment "Compromise or abnormality of the process of spermatogenesis" ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_689 a rdfs:Class ;
rdfs:label "lymphangitis" ;
rdfs:subClassOf obo:MPATH_201 .
obo:MPATH_758 a rdfs:Class ;
rdfs:label "renal interstitial mineralisation" ;
rdfs:comment "Small foci of mineralization within the interstitium between tubules." ;
rdfs:subClassOf obo:MPATH_757 .
obo:MPATH_211 a rdfs:Class ;
rdfs:label "failed transfer of maternal immunoglobulin" ;
rdfs:comment "Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins." ;
rdfs:subClassOf obo:MPATH_209 .
obo:MPATH_36 a rdfs:Class ;
rdfs:label "calcium deposition" ;
rdfs:comment "Intra or extracellular deposition of calcium usually as calcium phosphate." ;
rdfs:subClassOf obo:MPATH_555 .
obo:MPATH_393 a rdfs:Class ;
rdfs:label "osteoblastoma" ;
rdfs:comment "Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_521 a rdfs:Class ;
rdfs:label "splenic marginal zone lymphoma" ;
rdfs:comment "A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen." ;
rdfs:subClassOf obo:MPATH_519 .
obo:MPATH_201 a rdfs:Class ;
rdfs:label "vasculitis" ;
rdfs:comment "Inflammation of a blood vessel." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_464 a rdfs:Class ;
rdfs:label "cataract; lens extrusion" ;
rdfs:comment "Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye." ;
rdfs:subClassOf obo:MPATH_29 .
obo:MPATH_741 a rdfs:Class ;
rdfs:label "splenomegaly" ;
rdfs:comment "An increase in size of the spleen." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_693 a rdfs:Class ;
rdfs:label "pyometra" ;
rdfs:subClassOf obo:MPATH_673 .
obo:MPATH_493 a rdfs:Class ;
rdfs:label "membraneoproliferative glomerulonephritis" ;
rdfs:comment "A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,." ;
rdfs:subClassOf obo:MPATH_197 .
obo:MPATH_844 a rdfs:Class ;
rdfs:label "biliary stasis" ;
rdfs:comment "Cessation of the flow of bile due to bile duct blockage or overproduction." ;
rdfs:subClassOf obo:MPATH_843 .
obo:MPATH_635 a rdfs:Class ;
rdfs:label "hydronephrosis" ;
rdfs:comment "Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia." ;
rdfs:subClassOf obo:MPATH_708 .
obo:MPATH_185 a rdfs:Class ;
rdfs:label "parenchymal regeneration" ;
rdfs:comment "Post-injury regeneration of the functional tissue parenchyma. Eg. Liver." ;
rdfs:subClassOf obo:MPATH_175 .
obo:MPATH_869 a rdfs:Class ;
rdfs:label "intussception" ;
rdfs:comment "Condition in which a part of the intestine has invaginated into another section of intestine," ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_292 a rdfs:Class ;
rdfs:label "mucinous cystadenocarcinoma" ;
rdfs:comment "Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3)." ;
rdfs:subClassOf obo:MPATH_276 .
obo:MPATH_173 a rdfs:Class ;
rdfs:label "myeloid metaplasia" ;
rdfs:comment "A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow." ;
rdfs:subClassOf obo:MPATH_512 .
obo:MPATH_360 a rdfs:Class ;
rdfs:label "melanoma in situ" ;
rdfs:comment "A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2)." ;
rdfs:subClassOf obo:MPATH_358 , obo:MPATH_556 .
obo:MPATH_302 a rdfs:Class ;
rdfs:label "pituicytoma" ;
rdfs:comment "Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_638 a rdfs:Class ;
rdfs:label "cellulitis" ;
rdfs:comment "An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_78 a rdfs:Class ;
rdfs:label "incomplete closure" ;
rdfs:comment "Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_367 a rdfs:Class ;
rdfs:label "carcinoid tumor" ;
rdfs:comment "Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3)." ;
rdfs:subClassOf obo:MPATH_366 .
obo:MPATH_271 a rdfs:Class ;
rdfs:label "adenomatous polyposis coli" ;
rdfs:comment "Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_556 .
obo:MPATH_864 a rdfs:Class ;
rdfs:label "otitis externa" ;
rdfs:comment "Inflammation of the outer ear." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_453 a rdfs:Class ;
rdfs:label "transitional cell papilloma" ;
rdfs:comment "Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1)." ;
rdfs:subClassOf obo:MPATH_450 .
obo:MPATH_418 a rdfs:Class ;
rdfs:label "liposarcoma" ;
rdfs:comment "Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3)." ;
rdfs:subClassOf obo:MPATH_415 , obo:MPATH_551 .
obo:MPATH_73 a rdfs:Class ;
rdfs:label "growth arrest" ;
rdfs:comment "The cessation of fetal or embryonic growth beyond a particular stage." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_146 a rdfs:Class .
obo:MPATH_504 a rdfs:Class ;
rdfs:label "non-lymphoid hematopoietic sarcomas" ;
rdfs:comment "Solid tumor mass composed of non-lymphoid haematopoietic cells." ;
rdfs:subClassOf obo:MPATH_335 , obo:MPATH_551 .
obo:MPATH_154 a rdfs:Class ;
rdfs:label "hyperkeratosis" ;
rdfs:comment "Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis." ;
rdfs:subClassOf obo:MPATH_149 .
obo:MPATH_644 a rdfs:Class ;
rdfs:label "crystalloid formation" ;
rdfs:comment "Accumulation of chitinase-like protein." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_433 a rdfs:Class ;
rdfs:label "nerve sheath tumor" ;
rdfs:comment "Neoplasms of the nerve sheath." ;
rdfs:subClassOf obo:MPATH_404 , obo:MPATH_570 .
obo:MPATH_186 a rdfs:Class ;
rdfs:label "complete parenchymal regeneration" ;
rdfs:comment "Complete healing through parenchymal regeneration - no fibrosis." ;
rdfs:subClassOf obo:MPATH_185 .
obo:MPATH_62 a rdfs:Class ;
rdfs:label "cyst" ;
rdfs:comment "Formation of an epithelium bounded cavity not associated with neoplasia." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_519 a rdfs:Class ;
rdfs:label "mature B-cell neoplasms" ;
rdfs:comment "Lymphomas originating in peripheral B cells." ;
rdfs:subClassOf obo:MPATH_516 .
obo:MPATH_711 a rdfs:Class ;
rdfs:label "situs ambiguus" ;
rdfs:subClassOf obo:MPATH_470 .
obo:MPATH_345 a rdfs:Class ;
rdfs:label "immunoblastic lymphoma" ;
rdfs:comment "obsolete; see MPATH525" .
obo:MPATH_34 a rdfs:Class ;
rdfs:label "amyloid deposition" ;
rdfs:comment "Extracellular deposition of amyloid protein." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_128 a rdfs:Class ;
rdfs:label "intra-epithelial neoplasia" ;
rdfs:comment "Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64." ;
rdfs:subClassOf obo:MPATH_556 .
obo:MPATH_255 a rdfs:Class ;
rdfs:label "adenoacanthoma" ;
rdfs:comment "Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_183 a rdfs:Class ;
rdfs:label "granulation tissue" ;
rdfs:comment "Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells." ;
rdfs:subClassOf obo:MPATH_607 .
obo:MPATH_215 a rdfs:Class ;
rdfs:label "granulomatous inflammation" ;
rdfs:comment "Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_670 a rdfs:Class ;
rdfs:label "granulomatous epicarditis" ;
rdfs:comment "A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium." ;
rdfs:subClassOf obo:MPATH_215 , obo:MPATH_645 .
obo:MPATH_328 a rdfs:Class ;
rdfs:label "leydig cell tumor" ;
rdfs:comment "Tumor derived from Leydig cells (M-8650/1)." ;
rdfs:subClassOf obo:MPATH_323 .
obo:MPATH_12 a rdfs:Class ;
rdfs:label "liquefactive necrosis" ;
rdfs:comment "Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_873 a rdfs:Class ;
rdfs:label "micropthalmia" ;
rdfs:comment "Reduced size of the eye globe." ;
rdfs:subClassOf obo:MPATH_770 .
obo:MPATH_362 a rdfs:Class ;
rdfs:label "mesonephroma" ;
rdfs:comment "Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_615 a rdfs:Class ;
rdfs:label "cardiomyopathy" ;
rdfs:comment "A disease of the heart muscle or myocardium proper." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_222 a rdfs:Class ;
rdfs:label "ceruminous adenocarcinoma" ;
rdfs:comment "Malignant carcinoma of the ceruminous gland (M-8420/3)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_268 .
obo:MPATH_114 a rdfs:Class ;
rdfs:label "bone marrow embolism" ;
rdfs:comment "Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_2 a rdfs:Class ;
rdfs:label "cell death" ;
rdfs:comment "Complete and irreversible cessation of metabolic activity." ;
rdfs:subClassOf obo:MPATH_597 .
obo:MPATH_586 a rdfs:Class ;
rdfs:label "polycystic disease" ;
rdfs:comment "A group of degenerative disorders resulting in multiple cysts in tissues." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_411 a rdfs:Class ;
rdfs:label "granular cell tumor/alveolar sarcoma" ;
rdfs:comment "obsolete. Use specific terms MPATH: 412 or MPATH: 413" .
obo:MPATH_168 a rdfs:Class ;
rdfs:label "lipomatous metaplasia" ;
rdfs:comment "Metaplasia resulting in formation of fat cells." ;
rdfs:subClassOf obo:MPATH_605 .
obo:MPATH_83 a rdfs:Class ;
rdfs:label "septation defect" ;
rdfs:comment "Any defect in the formation of septae not describable as perforation." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_851 a rdfs:Class ;
rdfs:label "auricular deformation" ;
rdfs:comment "acquired dysmorphology of the external pinna following trauma or infection." ;
rdfs:subClassOf obo:MPATH_850 .
obo:MPATH_862 a rdfs:Class ;
rdfs:label "flatus" ;
rdfs:comment "Accumulation or trapping of air" ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_622 a rdfs:Class ;
rdfs:label "steatosis" ;
rdfs:comment "Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_388 a rdfs:Class ;
rdfs:label "osseous and chondromatous tumor" ;
rdfs:comment "Neoplasms of bone and cartilage." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_395 a rdfs:Class ;
rdfs:label "osteofibroma" ;
rdfs:comment "Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0)." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_695 a rdfs:Class ;
rdfs:label "spindle cell sarcoma" ;
rdfs:subClassOf obo:MPATH_551 .
obo:MPATH_537 a rdfs:Class ;
rdfs:label "precursor T-cell lymphoblastic lymphoma/leukaemia" ;
rdfs:comment "Precursor T cell derived neoplasia. Most commonly found in the thymus." ;
rdfs:subClassOf obo:MPATH_536 .
obo:MPATH_607 a rdfs:Class ;
rdfs:label "healing and repair structure" ;
rdfs:comment "Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage." ;
rdfs:subClassOf obo:MPATH_603 .
obo:MPATH_106 a rdfs:Class ;
rdfs:label "fluid accumulation" ;
rdfs:comment "Abnormal accumulation of fluid; blood or lymph." ;
rdfs:subClassOf obo:MPATH_105 .
obo:MPATH_566 a rdfs:Class ;
rdfs:label "tumors of the meninges" ;
rdfs:subClassOf obo:MPATH_243 .
obo:MPATH_143 a rdfs:Class ;
rdfs:label "microglandular hyperplasia" ;
rdfs:comment "Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium." ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_422 a rdfs:Class ;
rdfs:label "lymphangiosarcoma" ;
rdfs:comment "A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3)." ;
rdfs:subClassOf obo:MPATH_419 , obo:MPATH_551 .
obo:MPATH_103 a rdfs:Class ;
rdfs:label "placental vascular defect" ;
rdfs:comment "Any defect in the maternal or embryonic placental circulation." ;
rdfs:subClassOf obo:MPATH_100 .
obo:MPATH_51 a rdfs:Class ;
rdfs:label "hypocalcification" ;
rdfs:comment "Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_778 a rdfs:Class ;
rdfs:label "corpora amylacea" ;
rdfs:comment "https://doi.org/10.1038/srep41807" ;
rdfs:subClassOf obo:MPATH_614 .
obo:MPATH_197 a rdfs:Class ;
rdfs:label "glomerulonephritis" ;
rdfs:comment "Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_432 a rdfs:Class ;
rdfs:label "myxosarcoma" ;
rdfs:comment "A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3)." ;
rdfs:subClassOf obo:MPATH_429 , obo:MPATH_551 .
obo:MPATH_295 a rdfs:Class ;
rdfs:label "papillary adenocarcinoma" ;
rdfs:comment "A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_840 a rdfs:Class ;
rdfs:label "granulomatous arthritis" ;
rdfs:comment "arthitis involving extensive macrophage infiltration into the joint." ;
rdfs:subClassOf obo:MPATH_195 , obo:MPATH_215 .
obo:MPATH_530 a rdfs:Class ;
rdfs:label "plasma cell neoplasms" ;
rdfs:comment "Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3)." ;
rdfs:subClassOf obo:MPATH_516 .
obo:MPATH_745 a rdfs:Class ;
rdfs:label "zenker's necrosis" ;
rdfs:comment "Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_457 a rdfs:Class ;
rdfs:label "placental site trophoblastic tumor" ;
rdfs:comment "Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1)." ;
rdfs:subClassOf obo:MPATH_454 .
obo:MPATH_205 a rdfs:Class ;
rdfs:label "immunodeficiency associated infection" ;
rdfs:comment "Infection with bacteria, viruses or fungi subsequent to immunodeficiency." .
obo:MPATH_194 a rdfs:Class ;
rdfs:label "immune mediated disease" ;
rdfs:comment "Tissue response to inappropriate immune/inflammatory process." ;
rdfs:subClassOf obo:MPATH_188 .
obo:MPATH_474 a rdfs:Class ;
rdfs:label "ectasia" ;
rdfs:comment "Dilation of a tubular structure." ;
rdfs:subClassOf obo:MPATH_66 .
obo:MPATH_875 a rdfs:Class ;
rdfs:label "cutaneous plasmacytosis" ;
rdfs:comment "cutaneous manifestation of plasmacytosis" ;
rdfs:subClassOf obo:MPATH_874 .
obo:MPATH_321 a rdfs:Class ;
rdfs:label "teratocarcinoma" ;
rdfs:comment "Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_310 , obo:MPATH_549 .
obo:MPATH_682 a rdfs:Class ;
rdfs:label "arteritis" ;
rdfs:subClassOf obo:MPATH_201 .
obo:MPATH_872 a rdfs:Class ;
rdfs:label "kyphosis" ;
rdfs:comment "Abnormality of the kyphotic curvature of the spine." ;
rdfs:subClassOf obo:MPATH_871 .
obo:MPATH_671 a rdfs:Class ;
rdfs:label "mastitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_761 a rdfs:Class ;
rdfs:label "muscle regeneration" ;
rdfs:comment "Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair." ;
rdfs:subClassOf obo:MPATH_607 .
obo:MPATH_45 a rdfs:Class ;
rdfs:label "protein deposition" ;
rdfs:comment "Non-specified intra or extracellular deposition of protein." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_196 a rdfs:Class ;
rdfs:label "dermatitis" ;
rdfs:comment "Inflammation of the skin." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_425 a rdfs:Class ;
rdfs:label "leiomyoma" ;
rdfs:comment "Benign neoplasm derived from smooth muscle cells. (M-8890/0)." ;
rdfs:subClassOf obo:MPATH_423 .
obo:MPATH_72 a rdfs:Class ;
rdfs:label "growth acceleration" ;
rdfs:comment "Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_84 a rdfs:Class ;
rdfs:label "supernumerary structure" ;
rdfs:comment "Additional structure whether normally located or not." ;
rdfs:subClassOf obo:MPATH_67 .
obo:MPATH_306 a rdfs:Class ;
rdfs:label "signet ring cell carcinoma" ;
rdfs:comment "Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_883 a rdfs:Class ;
rdfs:label "pneumonitis" ;
rdfs:comment "An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli." ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_443 a rdfs:Class ;
rdfs:label "inverted squamous papilloma" ;
rdfs:comment "A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_442 , obo:MPATH_445 .
obo:MPATH_403 a rdfs:Class ;
rdfs:label "paraganglioma" ;
rdfs:comment "A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0)." ;
rdfs:subClassOf obo:MPATH_398 .
obo:MPATH_491 a rdfs:Class ;
rdfs:label "polyp" ;
rdfs:comment "A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk." ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_157 a rdfs:Class ;
rdfs:label "pseudoepithelioma/pseudocarcinoma" ;
rdfs:comment "Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma." ;
rdfs:subClassOf obo:MPATH_149 .
obo:MPATH_581 a rdfs:Class ;
rdfs:label "desmoplasia" ;
rdfs:comment "Connective tissue proliferative reaction induced by a neoplastic process." ;
rdfs:subClassOf obo:MPATH_604 .
obo:MPATH_555 a rdfs:Class ;
rdfs:label "mineralisation" ;
rdfs:comment "Deposition of any homogeneous inorganic material." ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_884 a rdfs:Class ;
rdfs:label "histiocytic pneumonitis" ;
rdfs:comment "Pneumonitis involving subpleural histiocytosis." ;
rdfs:subClassOf obo:MPATH_883 .
obo:MPATH_597 a rdfs:Class ;
rdfs:label "cell and tissue damage process" ;
rdfs:comment "Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology." ;
rdfs:subClassOf obo:MPATH_596 .
obo:MPATH_229 a rdfs:Class ;
rdfs:label "sebaceous adenocarcinoma" ;
rdfs:comment "Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_268 .
obo:MPATH_117 a rdfs:Class ;
rdfs:label "skin embolism" ;
rdfs:comment "Occlusion of vessels, usually small arterioles in the dermis by various emboli." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_660 a rdfs:Class ;
rdfs:label "gastritis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_94 a rdfs:Class ;
rdfs:label "valve defect" ;
rdfs:comment "Malformation of the membranous folds of the heart that prevent reflux of fluid." ;
rdfs:subClassOf obo:MPATH_92 .
obo:MPATH_30 a rdfs:Class ;
rdfs:label "cystic medial necrosis" ;
rdfs:comment "Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_378 a rdfs:Class ;
rdfs:label "retinoblastoma" ;
rdfs:comment "Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3)." ;
rdfs:subClassOf obo:MPATH_373 .
obo:MPATH_653 a rdfs:Class ;
rdfs:label "langerhans cell histiocytosis" ;
rdfs:subClassOf obo:MPATH_652 .
obo:MPATH_338 a rdfs:Class ;
rdfs:label "granulocytic leukaemia" ;
rdfs:comment "obsolete following reclassification see: MPATH505" .
obo:MPATH_772 a rdfs:Class ;
rdfs:label "abnormal organ mass" ;
rdfs:comment "Abnormal mass of organ" ;
rdfs:subClassOf obo:MPATH_770 .
obo:MPATH_351 a rdfs:Class ;
rdfs:label "thymoma" ;
rdfs:comment "A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1)." ;
rdfs:subClassOf obo:MPATH_556 .
obo:MPATH_829 a rdfs:Class ;
rdfs:label "true hermaphrodite" ;
rdfs:comment "possession of both ovary and testis due to primary sex determination defect" ;
rdfs:subClassOf obo:MPATH_86 .
obo:MPATH_633 a rdfs:Class ;
rdfs:label "cholelithiasis" ;
rdfs:comment "Presence of concretions in the gallbladder or bile ducts." ;
rdfs:subClassOf obo:MPATH_614 .
obo:MPATH_806 a rdfs:Class ;
rdfs:label "lymphangioma circumscriptum" ;
rdfs:comment "Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles." ;
rdfs:subClassOf obo:MPATH_420 .
obo:MPATH_667 a rdfs:Class ;
rdfs:label "foreign body periodontitis" ;
rdfs:subClassOf obo:MPATH_666 .
obo:MPATH_756 a rdfs:Class ;
rdfs:label "polyarteritis nodosa" ;
rdfs:comment "Chronic inflammation in and around small and medium sized arteries, often in more than one location." ;
rdfs:subClassOf obo:MPATH_682 .
obo:MPATH_444 a rdfs:Class ;
rdfs:label "keratoacanthoma" ;
rdfs:comment "Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_442 .
obo:MPATH_23 a rdfs:Class ;
rdfs:label "peroxysomal defect" ;
rdfs:comment "Defect in the structure or function of the peroxysomes." ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_218 a rdfs:Class ;
rdfs:label "neoplasm" ;
rdfs:comment "A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant." ;
rdfs:subClassOf obo:MPATH_603 .
obo:MPATH_269 a rdfs:Class ;
rdfs:label "adenocarcinoma in situ" ;
rdfs:comment "A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2)." ;
rdfs:subClassOf obo:MPATH_268 , obo:MPATH_556 .
obo:MPATH_582 a rdfs:Class ;
rdfs:label "cicatricial alopecia" ;
rdfs:comment "Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals." ;
rdfs:subClassOf obo:MPATH_26 .
obo:MPATH_61 a rdfs:Class ;
rdfs:label "curvature defect" ;
rdfs:comment "Inappropriate curvature of a structure." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_508 a rdfs:Class ;
rdfs:label "myeloid dysplasias" ;
rdfs:comment "Haematopoietic proliferation with evidence of trilineage dysplasia." ;
rdfs:subClassOf obo:MPATH_515 .
obo:MPATH_767 a rdfs:Class ;
rdfs:label "Meckel's diverticulum" ;
rdfs:comment "A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth." ;
rdfs:subClassOf obo:MPATH_68 .
obo:MPATH_681 a rdfs:Class ;
rdfs:label "septicemia" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_317 a rdfs:Class ;
rdfs:label "seminoma" ;
rdfs:comment "Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3)." ;
rdfs:subClassOf obo:MPATH_310 .
obo:MPATH_8 a rdfs:Class ;
rdfs:label "fat necrosis" ;
rdfs:comment "Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_592 a rdfs:Class ;
rdfs:label "osteopetrosis" ;
rdfs:comment "Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness." ;
rdfs:subClassOf obo:MPATH_589 .
obo:MPATH_649 a rdfs:Class ;
rdfs:label "otitis media" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_259 a rdfs:Class ;
rdfs:label "mucoepidermoid carcinoma" ;
rdfs:comment "Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_384 a rdfs:Class ;
rdfs:label "cementoma" ;
rdfs:comment "Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0)." ;
rdfs:subClassOf obo:MPATH_379 .
obo:MPATH_782 a rdfs:Class ;
rdfs:label "phthisis bulbi" ;
rdfs:comment "Collapse of the eye globe associated with degenerative changes." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_421 a rdfs:Class ;
rdfs:label "lymphangiomyomatosis" ;
rdfs:comment "Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1)." ;
rdfs:subClassOf obo:MPATH_419 .
obo:MPATH_244 a rdfs:Class ;
rdfs:label "astrocytoma" ;
rdfs:comment "Glioma derived from astrocytes, both benign and malignant forms (M-9400/3)." ;
rdfs:subClassOf obo:MPATH_249 .
obo:MPATH_485 a rdfs:Class ;
rdfs:label "carcinoma in situ" ;
rdfs:comment "May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion." .
obo:MPATH_812 a rdfs:Class ;
rdfs:label "blister" ;
rdfs:comment "A collection of fluid underneath the top layer of skin (epidermis)." ;
rdfs:subClassOf obo:MPATH_1 .
obo:MPATH_299 a rdfs:Class ;
rdfs:label "pinealoma" ;
rdfs:comment "Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1)." ;
rdfs:subClassOf obo:MPATH_267 .
obo:MPATH_310 a rdfs:Class ;
rdfs:label "germ cell tumor" ;
rdfs:comment "Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells." ;
rdfs:subClassOf obo:MPATH_309 .
obo:MPATH_823 a rdfs:Class ;
rdfs:label "myxofibroma" ;
rdfs:comment "A benign neoplasm characterized by mucous and fibroblastic tissues." ;
rdfs:subClassOf obo:MPATH_407 .
obo:MPATH_655 a rdfs:Class ;
rdfs:label "lingual adenitis" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_16 a rdfs:Class ;
rdfs:label "myxoid/myxomatous degeneration" ;
rdfs:comment "A conversion of the connective tissues into a gelatinous or mucous substance." ;
rdfs:subClassOf obo:MPATH_15 .
obo:MPATH_56 a rdfs:Class ;
rdfs:label "developmental or adult structural defect" ;
rdfs:comment "Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult." ;
rdfs:subClassOf obo:MPATH_55 .
obo:MPATH_750 a rdfs:Class ;
rdfs:label "pulmonary adenomatosis" ;
rdfs:comment "Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_67 a rdfs:Class ;
rdfs:label "displacement and deformity" ;
rdfs:comment "Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_233 a rdfs:Class ;
rdfs:label "basal cell tumor" ;
rdfs:comment "Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_96 a rdfs:Class ;
rdfs:label "hypoplastic ventricle" ;
rdfs:comment "Reduction in cell number of one or both of the two lower chambers of the heart." ;
rdfs:subClassOf obo:MPATH_92 .
obo:MPATH_41 a rdfs:Class ;
rdfs:label "iron deposition" ;
rdfs:comment "Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin." ;
rdfs:subClassOf obo:MPATH_45 , obo:MPATH_555 .
obo:MPATH_861 a rdfs:Class ;
rdfs:label "edematous cholecystitis" ;
rdfs:comment "cholecystitis associated with edema" ;
rdfs:subClassOf obo:MPATH_860 .
obo:MPATH_356 a rdfs:Class ;
rdfs:label "hepatoblastoma" ;
rdfs:comment "Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3)." ;
rdfs:subClassOf obo:MPATH_352 .
obo:MPATH_664 a rdfs:Class ;
rdfs:label "granulomatous peritonitis" ;
rdfs:subClassOf obo:MPATH_215 , obo:MPATH_663 .
obo:MPATH_722 a rdfs:Class ;
rdfs:label "rhabdomyoma" ;
rdfs:comment "Benign stromal tumors of the soft tissue with skeletal muscle differentiation." ;
rdfs:subClassOf obo:MPATH_423 .
obo:MPATH_153 a rdfs:Class ;
rdfs:label "hypergranulosis" ;
rdfs:comment "Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis." ;
rdfs:subClassOf obo:MPATH_149 .
obo:MPATH_90 a rdfs:Class ;
rdfs:label "aneurysm" ;
rdfs:comment "Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_760 a rdfs:Class ;
rdfs:label "ovarian bursal cyst" ;
rdfs:comment "Marked dilatation of the ovarian bursa." ;
rdfs:subClassOf obo:MPATH_637 .
obo:MPATH_887 a rdfs:Class ;
rdfs:label "lymphatic metastasis" ;
rdfs:comment "Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin." ;
rdfs:subClassOf obo:MPATH_885 .
obo:MPATH_400 a rdfs:Class ;
rdfs:label "carotid body tumor" ;
rdfs:comment "Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1)." ;
rdfs:subClassOf obo:MPATH_398 .
obo:MPATH_410 a rdfs:Class ;
rdfs:label "giant cell tumor of soft tissue" ;
rdfs:comment "Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1)." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_677 a rdfs:Class ;
rdfs:label "pyelonephritis" ;
rdfs:subClassOf obo:MPATH_676 .
obo:MPATH_705 a rdfs:Class ;
rdfs:label "acinar atrophy" ;
rdfs:subClassOf obo:MPATH_127 .
obo:MPATH_373 a rdfs:Class ;
rdfs:label "CNS progenitor tumor" ;
rdfs:comment "Neoplasms derived from neuroepithelial precursors." ;
rdfs:subClassOf obo:MPATH_565 .
obo:MPATH_212 a rdfs:Class ;
rdfs:label "inflammation" ;
rdfs:comment "A tissue reaction to an internal or external injury." ;
rdfs:subClassOf obo:MPATH_194 .
obo:MPATH_559 a rdfs:Class ;
rdfs:label "acinar adenocarcinoma" ;
rdfs:comment "Tumor composed of small glandular clusters with small lumens." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_771 a rdfs:Class ;
rdfs:label "abnormal organ length" ;
rdfs:comment "Abnormality of extent of the normal long axis" ;
rdfs:subClassOf obo:MPATH_770 .
obo:MPATH_834 a rdfs:Class ;
rdfs:label "ovarian tubulostromal tumor" ;
rdfs:comment "non-malignant neoplasia of the ovary." ;
rdfs:subClassOf obo:MPATH_556 .
obo:MPATH_801 a rdfs:Class ;
rdfs:label "intervertebral disks prolapsed dorsally and ventrally" ;
rdfs:comment "Presence of dorsal and ventrally prolapsed disks in the same vertebral column." ;
rdfs:subClassOf obo:MPATH_742 .
obo:MPATH_630 a rdfs:Class ;
rdfs:label "karyomegaly" ;
rdfs:comment "Abnormally increased nuclear size." ;
rdfs:subClassOf obo:MPATH_460 .
obo:MPATH_818 a rdfs:Class ;
rdfs:label "focal pulmonary histiocytosis" ;
rdfs:subClassOf obo:MPATH_652 .
obo:MPATH_511 a rdfs:Class ;
rdfs:label "myeloproliferation (genetic)" ;
rdfs:comment "Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined." ;
rdfs:subClassOf obo:MPATH_510 .
obo:MPATH_320 a rdfs:Class ;
rdfs:label "struma ovarii" ;
rdfs:comment "Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0)." ;
rdfs:subClassOf obo:MPATH_310 , obo:MPATH_549 .
obo:MPATH_407 a rdfs:Class ;
rdfs:label "fibroma" ;
rdfs:comment "Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0)." ;
rdfs:subClassOf obo:MPATH_404 , obo:MPATH_551 .
obo:MPATH_591 a rdfs:Class ;
rdfs:label "fatty infiltration" ;
rdfs:comment "Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage." ;
rdfs:subClassOf obo:MPATH_607 .
obo:MPATH_447 a rdfs:Class ;
rdfs:label "squamous cell carcinoma in situ" ;
rdfs:comment "Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_442 , obo:MPATH_556 .
obo:MPATH_716 a rdfs:Class ;
rdfs:label "ciliary motility defect" ;
rdfs:subClassOf obo:MPATH_17 .
obo:MPATH_113 a rdfs:Class ;
rdfs:label "atrial embolism" ;
rdfs:comment "Occlusion of the outflow tract of the right atrium by a thrombus." ;
rdfs:subClassOf obo:MPATH_110 .
obo:MPATH_50 a rdfs:Class ;
rdfs:label "glycogen depletion" ;
rdfs:comment "Reduction in intracellular glycogen content." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_593 a rdfs:Class ;
rdfs:label "myeloma" ;
rdfs:comment "Plasma cell myeloma - (ICD-O 9732/3)." .
obo:MPATH_287 a rdfs:Class ;
rdfs:label "islet cell adenoma" ;
rdfs:comment "Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_258 a rdfs:Class ;
rdfs:label "mesodermal mixed tumor" ;
rdfs:comment "Neoplasm showing multiple phases, derived from mesoderm (M-8951/3)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_580 a rdfs:Class ;
rdfs:label "erosion" ;
rdfs:comment "Partial epithelial denudation not penetrating to the basement membrane." ;
rdfs:subClassOf obo:MPATH_15 .
obo:MPATH_293 a rdfs:Class ;
rdfs:label "mucinous cystadenoma" ;
rdfs:comment "A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_247 a rdfs:Class ;
rdfs:label "ependymoma" ;
rdfs:comment "Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3)." ;
rdfs:subClassOf obo:MPATH_249 .
obo:MPATH_793 a rdfs:Class ;
rdfs:label "reactive splenomegaly" ;
rdfs:comment "An increase in the size of the spleen due to ongoing acute or chronic infection." ;
rdfs:subClassOf obo:MPATH_188 .
obo:MPATH_576 a rdfs:Class ;
rdfs:label "trichofolliculoma" ;
rdfs:comment "Basaloid neoplasm with numerous mature hair follicles and hair formation." ;
rdfs:subClassOf obo:MPATH_575 .
obo:MPATH_202 a rdfs:Class ;
rdfs:label "immunodeficiency disease" ;
rdfs:comment "Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease." ;
rdfs:subClassOf obo:MPATH_188 .
obo:MPATH_288 a rdfs:Class ;
rdfs:label "islet cell carcinoma" ;
rdfs:comment "Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3)." ;
rdfs:subClassOf obo:MPATH_267 , obo:MPATH_549 .
obo:MPATH_738 a rdfs:Class ;
rdfs:label "uterine cystic endometrial hyperplasia" ;
rdfs:comment "The uterus of older female mice often becomes distended with numerous fluid filled cysts that extend from the endometrium." ;
rdfs:subClassOf obo:MPATH_134 .
obo:MPATH_176 a rdfs:Class ;
rdfs:label "connective tissue replacement" ;
rdfs:comment "Replacement of connective tissue by fibro-fatty deposits and scar tissue." ;
rdfs:subClassOf obo:MPATH_175 .
obo:MPATH_794 a rdfs:Class ;
rdfs:label "melena" ;
rdfs:comment "Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage." ;
rdfs:subClassOf obo:MPATH_119 .
obo:MPATH_604 a rdfs:Class ;
rdfs:label "defective growth and differentiation process" ;
rdfs:comment "Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells." ;
rdfs:subClassOf obo:MPATH_596 .
obo:MPATH_121 a rdfs:Class ;
rdfs:label "hematoma" ;
rdfs:comment "A localised deposition of clotted or partially clotted extravasated blood." ;
rdfs:subClassOf obo:MPATH_119 .
obo:MPATH_282 a rdfs:Class ;
rdfs:label "infiltrating duct carcinoma" ;
rdfs:comment "Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3)." ;
rdfs:subClassOf obo:MPATH_268 , obo:MPATH_549 .
obo:MPATH_526 a rdfs:Class ;
rdfs:label "diffuse large B-cell lymphoma, histiocyte associated" ;
rdfs:comment "Diffuse large B-cell lymphoma with more than 50% histiocytes." ;
rdfs:subClassOf obo:MPATH_523 .
obo:MPATH_656 a rdfs:Class ;
rdfs:label "hemolysis" ;
rdfs:comment "Rupture or disruption of erythrocytes with release of contents." ;
rdfs:subClassOf obo:MPATH_25 .
obo:MPATH_856 a rdfs:Class ;
rdfs:label "bullous emphysema" ;
rdfs:comment "Rupture of alveolar walls result in large rounded open air spaces in the lung" ;
rdfs:subClassOf obo:MPATH_31 .
obo:MPATH_340 a rdfs:Class ;
rdfs:label "megakaryocytic leukaemia" ;
rdfs:comment "Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue." ;
rdfs:subClassOf obo:MPATH_496 .
obo:MPATH_377 a rdfs:Class ;
rdfs:label "pheochromocytoma" ;
rdfs:comment "A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3)." ;
rdfs:subClassOf obo:MPATH_366 .
obo:MPATH_170 a rdfs:Class ;
rdfs:label "oncocytic metaplasia" ;
rdfs:comment "Appearance of oncocytic cells in for example an epithelium or tumor." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_868 a rdfs:Class ;
rdfs:label "uterine ectasia" ;
rdfs:comment "Dilation of the uterus" ;
rdfs:subClassOf obo:MPATH_474 .
obo:MPATH_276 a rdfs:Class ;
rdfs:label "cystadenocarcinoma" ;
rdfs:comment "Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3)." ;
rdfs:subClassOf obo:MPATH_268 .
obo:MPATH_227 a rdfs:Class ;
rdfs:label "eccrine papillary adenoma" ;
rdfs:comment "Papillary form of eccrine sweat gland adenoma. (M -8408/0)." ;
rdfs:subClassOf obo:MPATH_219 , obo:MPATH_270 .
obo:MPATH_414 a rdfs:Class ;
rdfs:label "histiocytic sarcoma" ;
rdfs:comment "redundant use MPATH506" .
obo:MPATH_236 a rdfs:Class ;
rdfs:label "angiofibroma" ;
rdfs:comment ".A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0)." ;
rdfs:subClassOf obo:MPATH_235 .
obo:MPATH_77 a rdfs:Class ;
rdfs:label "homoeotic change" ;
rdfs:comment "Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias." ;
rdfs:subClassOf obo:MPATH_599 .
obo:MPATH_552 a rdfs:Class ;
rdfs:label "Clara cell adenoma" ;
rdfs:comment "Benign tumor of the Clara cells of the bronchioalveolar epithelium." .
obo:MPATH_337 a rdfs:Class ;
rdfs:label "erythroid leukaemia" ;
rdfs:comment "Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue." ;
rdfs:subClassOf obo:MPATH_496 .
obo:MPATH_110 a rdfs:Class ;
rdfs:label "embolus" ;
rdfs:comment "A plug formed from a variety of materials occluding a vessel or tube." ;
rdfs:subClassOf obo:MPATH_105 .
obo:MPATH_335 a rdfs:Class ;
rdfs:label "hematopoietic/lymphoid malignancies/disorder" ;
rdfs:comment "Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages." ;
rdfs:subClassOf obo:MPATH_218 .
obo:MPATH_515 a rdfs:Class ;
rdfs:label "non-Lymphoid neoplasias" ;
rdfs:comment "Hematological neoplasias of non-lymphoid origin." ;
rdfs:subClassOf obo:MPATH_335 .
obo:MPATH_496 a rdfs:Class ;
rdfs:label "Non-Lymphoid leukaemias" ;
rdfs:comment "Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition." ;
rdfs:subClassOf obo:MPATH_515 .
obo:MPATH_783 a rdfs:Class ;
rdfs:label "B6 dermatitis" ;
rdfs:comment "Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice." ;
rdfs:subClassOf obo:MPATH_196 .
a rdfs:Class ;
rdfs:comment "An unconstrained type or object" .
obo:MPATH_845 a rdfs:Class ;
rdfs:label "partial abortion" ;
rdfs:comment "Evidence of residual placenta in utero without embryo." ;
rdfs:subClassOf obo:MPATH_100 .
obo:MPATH_266 a rdfs:Class ;
rdfs:label "fibroadenoma" ;
rdfs:comment "A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0)." ;
rdfs:subClassOf obo:MPATH_264 .
obo:MPATH_260 a rdfs:Class ;
rdfs:label "mullerian mixed tumor" ;
rdfs:comment "Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3)." ;
rdfs:subClassOf obo:MPATH_254 .
obo:MPATH_490 a rdfs:Class ;
rdfs:label "adenomatous polyp" ;
rdfs:comment "Benign neoplastic growth containing areas of adenomatous structure (progression)." ;
rdfs:subClassOf obo:MPATH_270 .
obo:MPATH_330 a rdfs:Class ;
rdfs:label "ovarian stromal tumor" ;
rdfs:comment "Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1)." ;
rdfs:subClassOf obo:MPATH_254 , obo:MPATH_323 .
obo:MPATH_548 a rdfs:Class ;
rdfs:label "papillary transitional cell carcinoma" ;
rdfs:comment "A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells." ;
rdfs:subClassOf obo:MPATH_264 , obo:MPATH_450 .
obo:MPATH_627 a rdfs:Class ;
rdfs:label "pyogranulomatous inflammation" ;
rdfs:comment "An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells." ;
rdfs:subClassOf obo:MPATH_215 .
obo:MPATH_500 a rdfs:Class ;
rdfs:label "myeloproliferative disease-like myeloid leukaemia" ;
rdfs:comment "Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts." ;
rdfs:subClassOf obo:MPATH_342 .
obo:MPATH_688 a rdfs:Class ;
rdfs:label "aortitis" ;
rdfs:subClassOf obo:MPATH_201 .
obo:MPATH_190 a rdfs:Class ;
rdfs:label "type I hypersensitivity" ;
rdfs:comment "This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks." ;
rdfs:subClassOf obo:MPATH_189 .
obo:MPATH_876 a rdfs:Class ;
rdfs:label "systemic plasmacytosis" ;
rdfs:comment "systemic manifestation of plasmacytosis. Disseminated in the circulation." ;
rdfs:subClassOf obo:MPATH_874 .
obo:MPATH_124 a rdfs:Class ;
rdfs:label "infarct" ;
rdfs:comment "An area of necrosis resulting from a sudden cessation of arterial or venous blood supply." ;
rdfs:subClassOf obo:MPATH_105 .
obo:MPATH_641 a rdfs:Class ;
rdfs:label "epidermal inclusion cyst" ;
rdfs:comment "Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris." ;
rdfs:subClassOf obo:MPATH_62 .
obo:MPATH_139 a rdfs:Class ;
rdfs:label "goblet cell hyperplasia" ;
rdfs:comment "Benign proliferation of goblet cells." ;
rdfs:subClassOf obo:MPATH_138 .
obo:MPATH_686 a rdfs:Class ;
rdfs:label "amputation" ;
rdfs:subClassOf obo:MPATH_67 .
obo:MPATH_429 a rdfs:Class ;
rdfs:label "myxomatous tumor" ;
rdfs:comment "Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix." ;
rdfs:subClassOf obo:MPATH_404 .
obo:MPATH_48 a rdfs:Class ;
rdfs:label "decalcification" ;
rdfs:comment "Process of loss of calcium from normally calcified tissue, usually bone." ;
rdfs:subClassOf obo:MPATH_47 .
obo:MPATH_88 a rdfs:Class ;
rdfs:label "nephroblastomatosis" ;
rdfs:comment "Obsolete - subsumed into MPATH:82" .
obo:MPATH_742 a rdfs:Class ;
rdfs:label "intervertebral disk prolapse" ;
rdfs:comment "Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma." ;
rdfs:subClassOf obo:MPATH_626 .
obo:MPATH_164 a rdfs:Class ;
rdfs:label "gastric metaplasia" ;
rdfs:comment "Appearance of heterotopic gastric epithelium." ;
rdfs:subClassOf obo:MPATH_162 .
obo:MPATH_436 a rdfs:Class ;
rdfs:label "neurofibromatosis" ;
rdfs:comment "Systemic manifestation of MPATH:435 ( M-9540/1)." ;
rdfs:subClassOf obo:MPATH_433 .
obo:MPATH_135 a rdfs:Class ;
rdfs:label "epithelial and stromal hyperplasia" ;
rdfs:comment "Abnormal proliferation of epithelial and stromal cells." ;
rdfs:subClassOf obo:MPATH_602 .
obo:MPATH_541 a rdfs:Class ;
rdfs:label "T large cell anaplastic lymphoma" ;
rdfs:comment "Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma." ;
rdfs:subClassOf obo:MPATH_540 .
obo:MPATH_522 a rdfs:Class ;
rdfs:label "follicular B cell lymphoma" ;
rdfs:comment "A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse." ;
rdfs:subClassOf obo:MPATH_519 .
obo:MPATH_700 a rdfs:Class ;
rdfs:label "ascites" ;
rdfs:subClassOf obo:MPATH_33 .
obo:MPATH_469 a rdfs:Class ;
rdfs:label "symmetry defect" ;
rdfs:comment "Any aberration of the normal symmetrical organisation of the body pattern." ;
rdfs:subClassOf obo:MPATH_56 .
obo:MPATH_608 a rdfs:Class ;
rdfs:label "abscess" ;
rdfs:comment "A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation." ;
rdfs:subClassOf obo:MPATH_607 .
obo:MPATH_132 a rdfs:Class ;
rdfs:label "severe intra-epithelial neoplasia" ;
rdfs:comment "Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone." ;
rdfs:subClassOf obo:MPATH_128 .
obo:MPATH_789 a rdfs:Class ;
rdfs:label "trichogranuloma" ;
rdfs:comment "Dermal granuloma surrounding hair fibers." ;
rdfs:subClassOf obo:MPATH_847 .
obo:MPATH_727 a rdfs:Class ;
rdfs:label "hepatic hemosiderosis" ;
rdfs:subClassOf obo:MPATH_726 .
obo:MPATH_879 a rdfs:Class ;
rdfs:label "gingivitis" ;
rdfs:comment "Inflammation of the tooth gum" ;
rdfs:subClassOf obo:MPATH_212 .
obo:MPATH_7 a rdfs:Class ;
rdfs:label "coagulation necrosis" ;
rdfs:comment "A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists." ;
rdfs:subClassOf obo:MPATH_4 .
obo:MPATH_572 a rdfs:Class ;
rdfs:label "ossifying fibroma" ;
rdfs:comment "Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts." ;
rdfs:subClassOf obo:MPATH_388 .
obo:MPATH_852 a rdfs:Class ;
rdfs:label "plasmacytosis" ;
rdfs:comment "A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood." ;
rdfs:subClassOf obo:MPATH_194 .
obo:MPATH_463 a rdfs:Class ;
rdfs:label "cataract; cortical liquefactive" ;
rdfs:comment "Of developmental origins; nucleus and cortex become completely liquefied in post-natal life." ;
rdfs:subClassOf obo:MPATH_29 .
obo:MPATH_733 a rdfs:Class ;
rdfs:label "mucometra" ;
rdfs:comment "A uterus distended with a fluid containing large quantities of mucin." ;
rdfs:subClassOf obo:MPATH_547 .
obo:IAO_0000115 a rdf:Property ;
rdfs:label "definition" ;
rdfs:range xsd:string .
a rdf:Property ;
rdfs:label "is a" ;
rdfs:range .