PREFIX obo:
PREFIX rdf:
PREFIX rdfs:
PREFIX xsd:
obo:OBI_0000916 a rdfs:Class ;
rdfs:label "flow cytometry assay" ;
rdfs:comment "A cytometry assay in which an input cell population is put in solution, is passed by a laser, and optical sensors are used to detect scattering of the laser light and/or fluorescence of specific markers to count and characterize the particles in solution." ;
rdfs:subClassOf obo:OBI_0000070 .
a rdfs:Class ;
rdfs:label "metastasis" ;
rdfs:comment "The spread or migration of cancer cells from one part of the body (where they first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor. [ NCI ]" ;
rdfs:subClassOf obo:OBI_1110122 .
a rdfs:Class ;
rdfs:label "biomarker text-mining category"@en ;
rdfs:comment "A placeholder for grouping classes for biomarker text-minig purposes." ;
rdfs:subClassOf obo:IAO_0000030 .
obo:PR_000015561 a rdfs:Class ;
rdfs:label "osteopontin" ;
rdfs:comment "A protein that is a translation product of the human SPP1 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
a rdf:Property ;
rdfs:label "isBiomarkerOfAging"@en ;
rdfs:range .
a rdfs:Class ;
rdfs:label "snoring measurement" ;
rdfs:comment "quantification of some aspect of snoring such as frequency or severity" ;
rdfs:subClassOf .
obo:BMONT_0000066 a rdf:Property ;
rdfs:label "isDiagnosticBiomarkerFor" ;
rdfs:range .
obo:BMONT_0000067 a rdf:Property ;
rdfs:label "isMonitoringBiomarkerFor" ;
rdfs:range .
obo:BMONT_0000097 a rdf:Property ;
rdfs:label "isDigitalBiomarkerFor" ;
rdfs:range .
obo:PR_000001393 a rdfs:Class ;
rdfs:label "interleukin-6" ;
rdfs:comment "A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "chromosome-type aberration frequency" ;
rdfs:comment "Frequency of chromosome-type chromosomal aberrations in human peripheral blood (typically resulting in damage to both chromatids)." ;
rdfs:subClassOf .
obo:OPMI_0000451 a rdfs:Class ;
rdfs:label "cell lineage biomarker"@en ;
rdfs:comment "A biomarker that is an indicator of a cell lineage or cell type" ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:CARO_0000043 a rdfs:Class ;
rdfs:label "tissue" ;
rdfs:comment "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." ;
rdfs:subClassOf obo:UBERON_0000465 .
obo:OGG_3000023411 a rdfs:Class ;
rdfs:label "SIRT1" ;
rdfs:comment "sirtuin 1" ;
rdfs:subClassOf obo:OGG_0000000002 .
obo:BMONT_0000109 a rdfs:Class ;
rdfs:label "dynamic susceptibility contrast" ;
rdfs:comment "Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) provides a noninvasive means to create high resolution maps of the regional distribution of cerebral blood volume (CBV). Most DSC MRI studies conducted to date have focused on the evaluation of patients with cerebral neoplasms, ischemia or infarction, and epilepsy." ;
rdfs:subClassOf obo:NCIT_C16809 .
obo:CHEBI_17347 a rdfs:Class ;
rdfs:label "testosterone" ;
rdfs:comment "An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.." ;
rdfs:subClassOf obo:CHEBI_35341 .
obo:OBI_0000655 a rdfs:Class ;
rdfs:label "blood specimen" ;
rdfs:comment "a material entity derived from a portion of blood collected from an organism" ;
rdfs:subClassOf obo:OBI_0100051 .
obo:OGG_0000000002 a rdfs:Class ;
rdfs:label "gene"@en ;
rdfs:comment "A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule. " ;
rdfs:subClassOf obo:BFO_0000040 .
a rdfs:Class ;
rdfs:label "glucose metabolism measurement" ;
rdfs:comment "Quantification of a glucose metabolic process." ;
rdfs:subClassOf .
obo:BMONT_0000099 a rdf:Property ;
rdfs:label "isImagingBiomarkerFor" ;
rdfs:range .
obo:BFO_0000034 a rdfs:Class ;
rdfs:label "function"@en ;
rdfs:subClassOf obo:BFO_0000016 .
obo:CHEBI_16737 a rdfs:Class ;
rdfs:label "creatinine" ;
rdfs:comment "A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine." ;
rdfs:subClassOf obo:CHEBI_23367 .
a rdfs:Class ;
rdfs:label "germline genotype" ;
rdfs:comment "The total sum of the genetic information of an organism's germline" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "sleep depth" ;
rdfs:comment "self-reported assessment of how difficult an individual is to wake" ;
rdfs:subClassOf .
obo:MAXO_0000004 a rdfs:Class ;
rdfs:label "surgical procedure"@en ;
rdfs:comment "A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery." ;
rdfs:subClassOf obo:MAXO_0000001 .
a rdfs:Class ;
rdfs:label "wild type genotype" ;
rdfs:subClassOf .
obo:BFO_0000017 a rdfs:Class ;
rdfs:label "realizable entity"@en ;
rdfs:subClassOf obo:BFO_0000020 .
obo:UBERON_0001988 a rdfs:Class ;
rdfs:label "feces" ;
rdfs:comment "Portion of semisolid bodily waste discharged through the anus[MW,modified]." ;
rdfs:subClassOf obo:UBERON_0000174 .
obo:UBERON_0000465 a rdfs:Class ;
rdfs:label "material anatomical entity" ;
rdfs:comment "Anatomical entity that has mass." ;
rdfs:subClassOf obo:UBERON_0001062 .
obo:NCIT_C68763 a rdfs:Class ;
rdfs:label "Valid Biomarker" ;
rdfs:subClassOf obo:OPMI_0000445 .
a rdfs:Class ;
rdfs:label "normality"@en ;
rdfs:comment "normality is the quality in which the value may differ from normal or average"@en ;
rdfs:subClassOf obo:BFO_0000019 .
a rdfs:Class ;
rdfs:label "hayflick limit"@en ;
rdfs:comment """The Hayflick limit refers to the discovery by Leonard Hayflick that normal human cells grown in culture can only divide a finite number of times before entering a state of senescence, where they cease to divide.
It describes a limit on the process of cell division and is related to the concept of cellular senescence.""" ;
rdfs:subClassOf .
obo:NCIT_C17369 a rdfs:Class ;
rdfs:label "Imaging Technique" ;
rdfs:comment "Any technology or method that aids in the visualization of any biological process, cell, tissue or organ for use in screening, diagnosis, surgical procedures or therapy." ;
rdfs:subClassOf .
obo:BMONT_0000081 a rdfs:Class ;
rdfs:label "metric" ;
rdfs:comment "A metric is a quantifiable measure or indicator used to assess, analyze, and evaluate performance, progress, or quality in various contexts. Metrics provide objective data that can be compared, tracked over time, and used to make informed decisions, set goals, and drive improvement. In different fields and industries, metrics serve specific purposes and may encompass a wide range of parameters, variables, and key performance indicators (KPIs)." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "FVC change measurement"@en ;
rdfs:comment "Quantification of the rate of change in forced vital capacity of an individual over the course of time, used as an indicator of improvement or decay of pulmonary function." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "total cholesterol measurement" ;
rdfs:comment "A total cholesterol measurement is the quantification of cholesterol in blood, total cholesterol is defined as the sum of HDL, LDL, and VLDL." ;
rdfs:subClassOf .
obo:BMONT_0000065 a rdf:Property ;
rdfs:label "isPrognosticBiomarkerFor" ;
rdfs:range .
obo:PR_000007204 a rdfs:Class ;
rdfs:label "estrogen receptor" ;
rdfs:comment "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:DOID_37 a rdfs:Class ;
rdfs:label "skin disease" ;
rdfs:comment "An integumentary system disease that is located_in skin." ;
rdfs:subClassOf obo:DOID_4 .
a rdfs:Class ;
rdfs:label "telomere length" ;
rdfs:comment "A measurement of telomere length measures the number of TTAGGG repeats at the end of the chromosome. As cell division proceeds telomeres shorten, telomere length is measure of cellular aging." ;
rdfs:subClassOf .
obo:NCIT_C112312 a rdfs:Class ;
rdfs:label "Human Epidermal Growth Factor Receptor 2 Measurement" ;
rdfs:comment "The determination of the amount of human epidermal growth factor receptor 2 present in a sample." ;
rdfs:subClassOf .
obo:BMONT_0000043 a rdfs:Class ;
rdfs:label "regulatory standard" ;
rdfs:comment "A regulatory standard refers to a set of rules, guidelines, specifications, or requirements established by regulatory authorities to ensure the safety, efficacy, quality, and compliance of products, services, processes, or systems within a particular industry or jurisdiction. Regulatory standards play a critical role in protecting public health, safety, and welfare, promoting fair trade practices, and maintaining consumer confidence in regulated sectors." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:NCIT_C19498 .
a rdfs:Class ;
rdfs:label "maximal midexpiratory flow rate" ;
rdfs:comment "Measurement of rate of airflow over the middle half of a FORCED VITAL CAPACITY determination (from the 25 percent level to the 75 percent level). Common abbreviations are MMFR and FEF 25%-75%." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "genotype" ;
rdfs:comment "The total sum of the genetic information of an organism that is known and relevant to the experiment being performed, including chromosomal, plasmid, viral or other genetic material which has been introduced into the organism either prior to or during the experiment." ;
rdfs:subClassOf .
obo:BFO_0000145 a rdfs:Class ;
rdfs:label "relational quality"@en ;
rdfs:comment "b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])"@en ;
rdfs:subClassOf obo:BFO_0000019 .
a rdfs:Class ;
rdfs:label "abnormal"@en ;
rdfs:comment "A quality that has a value that is outside normal or average."@en ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "biological principle"@en ;
rdfs:comment "A biological principle is a fundamental concept or theory that underpins and explains biological phenomena and processes. It provides a foundational understanding of how biological systems function and guides research, experimentation, and interpretation in the field of biology." ;
rdfs:subClassOf obo:BFO_0000004 .
obo:UBERON_0001977 a rdfs:Class ;
rdfs:label "blood serum" ;
rdfs:comment "The portion of blood plasma that excludes clotting factors." ;
rdfs:subClassOf obo:UBERON_0000178 .
obo:BMONT_0000054 a rdfs:Class ;
rdfs:label "prediction model" ;
rdfs:comment "A prediction model, also known as a predictive model or forecasting model, is a statistical or computational tool used to make predictions or forecasts about future events or outcomes based on historical data and patterns. Prediction models are widely used across various fields, including finance, healthcare, marketing, weather forecasting, and sports analytics, among others. These models leverage patterns and relationships within the data to make predictions about future behavior or events." ;
rdfs:subClassOf obo:NCIT_C16866 .
obo:HP_0000118 a rdfs:Class ;
rdfs:label "Phenotypic abnormality" ;
rdfs:comment "A phenotypic abnormality." ;
rdfs:subClassOf obo:OGMS_0000023 .
obo:BMONT_0000030 a rdfs:Class ;
rdfs:label "drug development tool" ;
rdfs:comment """A biomarker, clinical outcome assesment, or any other method, material, or measure
determined to aid drug development and regulatory review (FD&C Act, section 507(e)(5)).""" ;
rdfs:seeAlso ;
rdfs:subClassOf obo:BFO_0000040 .
obo:BFO_0000030 a rdfs:Class ;
rdfs:label "object"@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:BMONT_0000136 a rdfs:Class ;
rdfs:label "leukocyte telomere length"@en ;
rdfs:comment "Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders." ;
rdfs:subClassOf obo:MI_0252 .
obo:BMONT_0000013 a rdfs:Class ;
rdfs:label "toxicity biomarker" ;
rdfs:comment "A biomarker that reports to the toxic effect of a drug on an in vitro or in vivo system." ;
rdfs:subClassOf obo:NCIT_C201367 .
obo:MAXO_0000647 a rdfs:Class ;
rdfs:label "chemotherapy"@en ;
rdfs:comment "The use of synthetic or naturally-occurring chemicals for the treatment of diseases." ;
rdfs:subClassOf obo:MAXO_0000002 .
obo:OBI_0302887 a rdfs:Class ;
rdfs:label "staining"@en ;
rdfs:comment "Staining is a process which results in the addition a class-specific (DNA, proteins, lipids, carbohydrates) dye to a substrate to qualify or quantify the presence of a specific compound."@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:SCDO_0000993 a rdfs:Class ;
rdfs:label "Respiratory Rate" ;
rdfs:comment "The number of times an organism breathes with the lungs (respiration) per unit time, usually per minute." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BMONT_0000071 a rdf:Property ;
rdfs:label "isPredictiveBiomarkerFor" ;
rdfs:range .
obo:BMONT_0000035 a rdfs:Class ;
rdfs:label "qualified biomarker" ;
rdfs:comment "Qualified biomarkers have the potential to provide valuable information that may reduce uncertainty in regulatory decisions during drug development. When a biomarker is qualified, it means that it has undergone a formal regulatory process to ensure that we can rely on it to have a specific interpretation and application in medical product development and regulatory review, within the stated context of use (COU) . It is important to note that a biomarker is qualified, and not the biomarker measurement method." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:CL_0000576 a rdfs:Class ;
rdfs:label "monocyte" ;
rdfs:comment "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." ;
rdfs:subClassOf obo:CL_0000738 .
a rdfs:Class ;
rdfs:label "hepatitis B virus infection" ;
rdfs:comment "INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact." ;
rdfs:subClassOf obo:DOID_409 .
obo:BFO_0000006 a rdfs:Class ;
rdfs:label "spatial region"@en ;
rdfs:subClassOf obo:BFO_0000141 .
obo:OBI_0000674 a rdfs:Class ;
rdfs:label "center value"@en ;
rdfs:comment "A data item that is produced as the output of a center calculation data transformation and represents the center value of the input data."@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:SYMP_0000837 a rdfs:Class ;
rdfs:label "chronic pain" ;
rdfs:comment "A pain that is characterized by ranging from mild to severe and which continues beyond the expected healing phase." ;
rdfs:subClassOf obo:SYMP_0000462 .
obo:BFO_0000182 a rdfs:Class ;
rdfs:label "history"@en ;
rdfs:subClassOf obo:BFO_0000015 .
a rdfs:Class ;
rdfs:label "FEV change measurement" ;
rdfs:comment "quantification of the rate of change in FEV of an individual over the course of time, used as an indicator of improvement or decay of pulmonary function" ;
rdfs:subClassOf .
obo:PR_000005965 a rdfs:Class ;
rdfs:label "cystatin-C" ;
rdfs:comment "A protein that is a translation product of the human CST3 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:UBERON_0001359 a rdfs:Class ;
rdfs:label "cerebrospinal fluid" ;
rdfs:comment "A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord." ;
rdfs:subClassOf obo:UBERON_0006314 .
obo:DOID_2394 a rdfs:Class ;
rdfs:label "ovarian cancer" ;
rdfs:comment "A female reproductive organ cancer that is located_in the ovary." ;
rdfs:subClassOf obo:DOID_162 .
obo:GO_0090399 a rdfs:Class ;
rdfs:label "replicative senescence" ;
rdfs:comment "A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging." ;
rdfs:subClassOf obo:GO_0009987 .
obo:MONDO_0005071 a rdfs:Class ;
rdfs:label "nervous system disorder" ;
rdfs:comment "A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves." ;
rdfs:subClassOf obo:DOID_4 .
a rdfs:Class ;
rdfs:label "heart failure" ;
rdfs:comment "Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction." ;
rdfs:subClassOf obo:DOID_114 .
obo:NCIT_C19498 a rdfs:Class ;
rdfs:label "Document" ;
rdfs:comment "A physical object, or electronic counterpart, that is characterized by containing writing which is meant to be human-readable." ;
rdfs:subClassOf obo:IAO_0000300 .
obo:DOID_12858 a rdfs:Class ;
rdfs:label "Huntington's disease" ;
rdfs:comment "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities." ;
rdfs:subClassOf obo:MONDO_0005559 .
obo:UBERON_0000178 a rdfs:Class ;
rdfs:label "blood" ;
rdfs:comment "A fluid that is composed of blood plasma and erythrocytes." ;
rdfs:subClassOf obo:UBERON_0006314 .
a rdfs:Class ;
rdfs:label "female"@en ;
rdfs:comment "female is a biological sex of an individual with female sexual organs."@en ;
rdfs:subClassOf obo:PATO_0001241 .
a rdfs:Class ;
rdfs:label "decline in stem cell function"@en ;
rdfs:comment "The decline in stem cell function is a well-established feature of the aging process and plays a crucial role in the overall degeneration of tissues and organs as we age. Stem cells are responsible for tissue regeneration, repair, and maintaining homeostasis in the body. As we age, the function of these stem cells diminishes, leading to impaired tissue repair, reduced regeneration capacity, and an increased risk of age-related diseases." ;
rdfs:subClassOf obo:MI_0252 .
obo:OGMS_0000073 a rdfs:Class ;
rdfs:label "diagnosis" ;
rdfs:comment "The representation of a conclusion of a diagnostic process."@en ;
rdfs:subClassOf obo:IAO_0000027 .
a rdfs:Class ;
rdfs:label "epigenetic clock"@en ;
rdfs:comment "Epigenetic clocks are mathematically derived age estimators that are based on combinations of methylation values that change with age at specific CpGs in the genome." ;
rdfs:subClassOf .
obo:NCIT_C201367 a rdfs:Class ;
rdfs:label "Safety Biomarker" ;
rdfs:comment "A biomarker measured before or after an exposure to a medical product or an environmental agent to indicate the likelihood, presence, or extent of toxicity as an adverse effect. (NIH-FDA BEST (Biomarkers, Endpoints, and other Tools) Resource)" ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:MONDO_0005438 a rdfs:Class ;
rdfs:label "metastatic malignant neoplasm in the lymph nodes" ;
rdfs:comment "The spread of a malignant neoplasm to the lymph nodes." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "MetaboHealth score"@en ;
rdfs:comment "The MetaboHealth score is a metabolomics-based health assessment that utilizes a panel of serum metabolic markers to evaluate an individual's metabolic health and its association with health outcomes." ;
rdfs:subClassOf obo:BMONT_0000081 .
a rdfs:Class ;
rdfs:label "cardiovascular disease" ;
rdfs:comment "A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma." ;
rdfs:subClassOf obo:DOID_1287 .
obo:BMONT_0000069 a rdfs:Class ;
rdfs:label "candidate biomarker" ;
rdfs:comment "Properly performed, biomarker discovery can lead to effective candidates that can ultimately serve as predictors of disease, medical condition, define therapeutic parameters, and many other applications in medicine." ;
rdfs:subClassOf obo:OPMI_0000445 .
a rdfs:Class ;
rdfs:label "excessive daytime sleepiness measurement" ;
rdfs:comment "quantification of excessive daytime sleepiness such as how often it occurs and its severity" ;
rdfs:subClassOf .
obo:CHEBI_27226 a rdfs:Class ;
rdfs:label "uric acid" ;
rdfs:comment "An oxopurine that is the final oxidation product of purine metabolism." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:OMIT_0024149 a rdfs:Class ;
rdfs:label "Leukoaraiosis" ;
rdfs:comment "Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS." ;
rdfs:subClassOf obo:OBI_1110122 .
obo:DOID_1324 a rdfs:Class ;
rdfs:label "lung cancer" ;
rdfs:comment "A respiratory system cancer that is located_in the lung." ;
rdfs:subClassOf obo:DOID_162 .
obo:STATO_0000415 a rdfs:Class ;
rdfs:label "accuracy"@en ;
rdfs:comment """in the context of binary classification, accuracy is defined as the proportion of true results (both true positives and true negatives) to the total number of cases examined (the sum of true positive, true negative, false positive and false negative).
It can be understood as a measure of the proximity of measurement results to the true value."""@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:BFO_0000029 a rdfs:Class ;
rdfs:label "site"@en ;
rdfs:subClassOf obo:BFO_0000141 .
obo:PR_000003015 a rdfs:Class ;
rdfs:label "prostate-specific antigen" ;
rdfs:comment "A trypsin that is a translation product of the human KLK3 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:BMONT_0000074 a rdfs:Class ;
rdfs:label "predictive biomarker text minig bin" ;
rdfs:comment "A placeholder for predictive biomarkers, organized based on the reasoning application 'isPredictiveBiomarkerFor some disease', to facilitate text mining and information retrieval for specific diseases." ;
rdfs:subClassOf .
obo:PR_000050369 a rdfs:Class ;
rdfs:label "D-dimer (human)" ;
rdfs:comment "A protein-containing complex that is the remnant of fibrin mesh degradation (fibrinolysis) by plasmin in human." ;
rdfs:subClassOf obo:PR_000000001 .
obo:OMIT_0024288 a rdfs:Class ;
rdfs:label "Dyslipidemias" ;
rdfs:comment "Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL." ;
rdfs:subClassOf obo:DOID_0014667 .
obo:OPMI_0000452 a rdfs:Class ;
rdfs:label "molecular biomarker"@en ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:OMIT_0016017 a rdfs:Class ;
rdfs:label "Lipid Peroxidation" ;
rdfs:comment "Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor." ;
rdfs:subClassOf obo:OMIT_0026291 .
obo:OBI_0000968 a rdfs:Class ;
rdfs:label "device" ;
rdfs:comment "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:CHEBI_47775 a rdfs:Class ;
rdfs:label "high-density lipoprotein cholesterol" ;
rdfs:comment "Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL)." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:PR_000016276 a rdfs:Class ;
rdfs:label "trefoil factor 3" ;
rdfs:comment "A protein that is a translation product of the human TFF3 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:OAE_0000001 a rdfs:Class ;
rdfs:label "adverse event" ;
rdfs:comment "a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:BMONT_0000057 a rdf:Property ;
rdfs:label "isCandidateBiomarkerFor" ;
rdfs:range .
obo:BMONT_0000031 a rdfs:Class ;
rdfs:label "Qualification of Medical Device Development Tools Guidance for Industry, Tool Developers, and Food and Drug Administration Staff" ;
rdfs:comment "A guidance that describes a voluntary program for the qualification of medical device development tools (MDDTs) for use in the evaluation of devices regulated by CDRH. Specifically, this guidance describes the framework for voluntary proposal and qualification of an MDDT, including definitions of applicable terms, criteria for evaluating an MDDT for a specific context of use, considerations for qualification, and the contents of a qualification package. CDRH believes that MDDTs will facilitate the development and timely evaluation of medical devices by providing a more efficient and predictable means for collecting information to support regulatory submissions and associated decision-making." ;
rdfs:seeAlso , ;
rdfs:subClassOf obo:ICO_0000233 .
obo:BMONT_0000113 a rdfs:Class ;
rdfs:label "gray matter volume" ;
rdfs:comment "Gray matter volume refers to the amount or volume of gray matter present in the brain. Gray matter consists of neuronal cell bodies, dendrites, and synapses, and it plays a crucial role in processing information and coordinating various functions within the brain. Measurements of gray matter volume are typically obtained using structural magnetic resonance imaging (MRI) techniques. MRI allows researchers and clinicians to visualize and quantify the volume of gray matter in specific brain regions or across the entire brain." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:MONDO_0001056 a rdfs:Class ;
rdfs:label "gastric cancer" ;
rdfs:comment "A primary or metastatic malignant neoplasm involving the stomach." ;
rdfs:subClassOf obo:DOID_162 .
obo:ADO_0000091 a rdfs:Class ;
rdfs:label "phosphorylated tau" ;
rdfs:comment "A protein that is phosphorylated through post-translational modification. Its accumulation reflects the formation of neurofibrillary tangles, synaptic impairment, and neuronal dysfunction." ;
rdfs:subClassOf obo:PR_000000001 .
obo:BFO_0000038 a rdfs:Class ;
rdfs:label "one-dimensional temporal region"@en ;
rdfs:subClassOf obo:BFO_0000008 .
a rdfs:Class ;
rdfs:label "intrinsic epigenetic age acceleration"@en ;
rdfs:comment "Intrinsic Epigenetic Age Acceleration refers to a metric used to assess biological aging, independent of age-related changes in blood cell composition. It is calculated using DNA methylation data and reflects \"cell-intrinsic\" aging processes. This measure is derived by regressing DNA methylation age (calculated through Horvath's epigenetic clock) on chronological age, but without factoring in shifts in blood cell types that typically occur with age. Because IEAA does not include these immune system-related factors, it is considered a measure of fundamental, internal cellular aging." ;
rdfs:subClassOf obo:BMONT_0000081 .
a rdfs:Class ;
rdfs:label "microbiome measurement" ;
rdfs:comment "quantification of some aspect of an individual's microbiome" ;
rdfs:subClassOf .
obo:BMONT_0000089 a rdfs:Class ;
rdfs:label "distance run" ;
rdfs:comment "Distance run refers to the total length covered by an individual while running, typically measured in miles or kilometers. It is a fundamental metric used to assess a runner's performance, track progress, and set goals for training and competition. Distance running is a popular form of aerobic exercise that provides numerous health benefits and is enjoyed by people of all ages and fitness levels." ;
rdfs:subClassOf obo:BMONT_0000086 .
a rdfs:Class ;
rdfs:label "DNAm PhenoAge"@en ;
rdfs:comment "https://pubmed.ncbi.nlm.nih.gov/31780646/" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "increased"@en ;
rdfs:comment "A quality that has a value that is increased compared to normal or average."@en ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "blood pressure" ;
rdfs:comment "PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:HP_0004934 a rdfs:Class ;
rdfs:label "Vascular calcification" ;
rdfs:comment "Abnormal calcification of the vasculature." ;
rdfs:subClassOf obo:GO_0008150 .
obo:DOID_9352 a rdfs:Class ;
rdfs:label "type 2 diabetes mellitus" ;
rdfs:comment "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." ;
rdfs:subClassOf obo:DOID_9351 .
obo:OPMI_0000456 a rdfs:Class ;
rdfs:label "prognostic biomarker"@en ;
rdfs:comment "A biomarker that provides information about the patient's overall outcome, regardless of therapy." ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:BMONT_0000117 a rdfs:Class ;
rdfs:label "axonal water fraction" ;
rdfs:comment "Axonal water fraction (AWF) is a metric used in diffusion MRI (dMRI) to characterize the microstructural properties of white matter in the brain. It quantifies the proportion of water molecules associated specifically with the axonal compartments within white matter tissue." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:OMIT_0033342 a rdfs:Class ;
rdfs:label "MAF" ;
rdfs:comment "v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog" ;
rdfs:subClassOf obo:OGG_0000000002 .
a rdfs:Class ;
rdfs:label "wake after sleep onset"@en ;
rdfs:comment "A measurement of the sum of durations of wakefulness episodes throughout the night, not including the wakefulness before sleep onset." ;
rdfs:subClassOf .
obo:MONDO_0005542 a rdfs:Class ;
rdfs:label "acute coronary syndrome" ;
rdfs:comment "Signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction." ;
rdfs:subClassOf obo:DOID_1287 .
obo:CHEBI_64646 a rdfs:Class ;
rdfs:label "amyloid-beta polypeptide 40" ;
rdfs:comment "A beta-amyloid that is a 40 amino acid polypeptide of sequence Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val." ;
rdfs:subClassOf obo:CHEBI_64645 .
a rdfs:Class ;
rdfs:label "venous thromboembolism" ;
rdfs:comment "Obstruction of a vein or VEINS (embolism) by a blood clot ( THROMBUS) in the blood stream." ;
rdfs:subClassOf obo:DOID_178 .
a rdfs:Class ;
rdfs:label "sleep quality" ;
rdfs:comment "quantification of some aspect of sleep quality, such as number of awakenings during a sleep interval or time taken to get to sleep. Sleep quality can be evaluated either through self-reporting, observation in a sleep lab or using a sleep monitoring device" ;
rdfs:subClassOf obo:MI_0252 .
obo:NCIT_C94342 a rdfs:Class ;
rdfs:label "Healthy Control" ;
rdfs:comment "A healthy subject that is matched with an affected individual in a trial." ;
rdfs:subClassOf obo:BFO_0000023 .
a rdfs:Class ;
rdfs:label "metastatic neoplasm" ;
rdfs:comment "A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology." ;
rdfs:subClassOf obo:MONDO_0005070 .
obo:PR_000016506 a rdfs:Class ;
rdfs:label "troponin I, cardiac muscle" ;
rdfs:comment "A protein that is a translation product of the human TNNI3 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:NCIT_C16234 a rdfs:Class ;
rdfs:label "Clinical Sensitivity" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "hepatitis C virus infection" ;
rdfs:comment "A Hepacivirus infectious disease which is a chronic bloodborne infectious disease caused by Hepatitis C virus. The symptoms include fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain and jaundice." ;
rdfs:subClassOf obo:DOID_409 .
obo:UBERON_0001062 a rdfs:Class ;
rdfs:label "anatomical entity" ;
rdfs:comment "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." ;
rdfs:subClassOf obo:BFO_0000004 .
obo:PATO_0001241 a rdfs:Class ;
rdfs:label "physical object quality" ;
rdfs:comment "A quality which inheres in a continuant." ;
rdfs:subClassOf obo:BFO_0000019 .
a rdfs:Class ;
rdfs:label "cortical thickness" ;
rdfs:comment "Is a quantification of the thickness of brain cortex, e.g. measured by MRI, used in the diagnosis of Alzheimer's disease and other neurological conditions" ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:OMIT_0033136 a rdfs:Class ;
rdfs:label "KLRB1" ;
rdfs:comment "killer cell lectin like receptor B1" ;
rdfs:subClassOf obo:OGG_0000000002 .
obo:IAO_0000415 a rdfs:Class ;
rdfs:label "hypothesis textual entity"@en ;
rdfs:comment "A textual entity that expresses an assertion that is intended to be tested."@en ;
rdfs:subClassOf obo:IAO_0000300 .
a rdfs:Class ;
rdfs:label "somatic genotype" ;
rdfs:comment "The total sum of the genetic information of an organism's somatic cells" ;
rdfs:subClassOf .
obo:MMO_0000113 a rdfs:Class ;
rdfs:label "oral glucose tolerance test" ;
rdfs:comment "A test in which glucose is given orally, often in solution, and blood samples taken afterward at specific time interval(s) to determine how quickly it is cleared from the blood." ;
rdfs:subClassOf obo:OBI_0000070 .
a rdfs:Class ;
rdfs:label "diabetic nephropathy" ;
rdfs:comment "Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis." ;
rdfs:subClassOf obo:DOID_557 .
obo:BFO_0000141 a rdfs:Class ;
rdfs:label "immaterial entity"@en ;
rdfs:subClassOf obo:BFO_0000004 .
obo:BMONT_0000047 a rdfs:Class ;
rdfs:label "cardiac function" ;
rdfs:comment "Cardiac function refers to the hearts capability to fulfill its task as the motor or pump of the blood circuit satisfying the bodies demands of oxygen and nutritive substances as well as the removal of waste products." ;
rdfs:subClassOf obo:GO_0008150 .
obo:MONDO_0000473 a rdfs:Class ;
rdfs:label "arterial disorder" ;
rdfs:comment "An impairment of the structure or function of the blood vessels which carry blood away from the heart." ;
rdfs:subClassOf obo:DOID_1287 .
obo:DOID_5844 a rdfs:Class ;
rdfs:label "myocardial infarction" ;
rdfs:comment "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." ;
rdfs:subClassOf obo:DOID_114 .
a rdfs:Class ;
rdfs:label "forced expiratory volume" ;
rdfs:comment "Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity." ;
rdfs:subClassOf .
obo:OBI_0001305 a rdfs:Class ;
rdfs:label "genotype information"@en ;
rdfs:comment "a genetic characteristics information that is about the genetic material of an organism and minimally includes information about the genetic background and can in addition contain information about specific alleles, genetic modifications, etc."@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:PR_000003035 a rdfs:Class ;
rdfs:label "cellular tumor antigen p53" ;
rdfs:comment "A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:OPMI_0000445 a rdfs:Class ;
rdfs:label "biomarker"@en ;
rdfs:comment "A material entity that has a measurable quality or process profile(s), which can be used as an indicator of an underlying biological state or identity." ;
rdfs:subClassOf obo:BMONT_0000030 .
obo:NCIT_C94515 a rdfs:Class ;
rdfs:label "Tumor Volume" ;
rdfs:comment "The volume of tumor." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:CMO_0000046 a rdfs:Class ;
rdfs:label "blood glucose level" ;
rdfs:comment "Measurement of the amount of glucose, the monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues which is one of the three dietary monosaccharides that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms, in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BFO_0000040 a rdfs:Class ;
rdfs:label "material entity"@en ;
rdfs:subClassOf obo:BFO_0000004 .
obo:STATO_0000220 a rdfs:Class ;
rdfs:label "false negative rate"@en ;
rdfs:comment "the false negative rate is a data item which denotes the proportion of missed detection of elements known to be meeting the detection criteria"@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:UBERON_0001088 a rdfs:Class ;
rdfs:label "urine" ;
rdfs:comment "Excretion that is the output of a kidney." ;
rdfs:subClassOf obo:UBERON_0000174 .
a rdfs:Class ;
rdfs:label "disease recurrence" ;
rdfs:comment "The recurrence of a disease after treatment" ;
rdfs:subClassOf .
obo:DOID_9970 a rdfs:Class ;
rdfs:label "obesity" ;
rdfs:comment "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." ;
rdfs:subClassOf obo:DOID_4 .
obo:CL_0000738 a rdfs:Class ;
rdfs:label "leukocyte" ;
rdfs:comment "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." ;
rdfs:subClassOf obo:CL_0000000 .
obo:SYMP_0000061 a rdfs:Class ;
rdfs:label "inflammation" ;
rdfs:comment "Inflammation is a general symptom where there is a local response to cellular injury that is marked by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling, and often loss of function and that serves as a mechanism initiating the elimination of noxious agents and of damaged tissue." ;
rdfs:subClassOf obo:SYMP_0000462 .
obo:DOID_1612 a rdfs:Class ;
rdfs:label "breast cancer" ;
rdfs:comment "A thoracic cancer that originates in the mammary gland." ;
rdfs:subClassOf obo:DOID_162 .
obo:BMONT_0000128 a rdfs:Class ;
rdfs:label "stride length" ;
rdfs:comment "Stride length is a key parameter in the study of human gait and biomechanics. It refers to the distance covered between two successive placements of the same foot. Essentially, it is the distance traveled during one complete gait cycle, involving both the left and right foot." ;
rdfs:seeAlso ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "vaginal microbiome measurement"@en ;
rdfs:comment "Quantification of some aspect of an individual's microbiome of the vagina." ;
rdfs:subClassOf .
obo:BMONT_0000072 a rdfs:Class ;
rdfs:label "monitoring biomarker text mining bin" ;
rdfs:comment "A placeholder for monitoring biomarkers, organized based on the reasoning application 'isMonitoringBiomarkerFor some disease', to facilitate text mining and information retrieval for specific diseases." ;
rdfs:subClassOf .
obo:BFO_0000011 a rdfs:Class ;
rdfs:label "spatiotemporal region"@en ;
rdfs:subClassOf obo:BFO_0000003 .
obo:GO_0010467 a rdfs:Class ;
rdfs:label "gene expression" ;
rdfs:comment "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." ;
rdfs:subClassOf obo:GO_0008150 .
obo:CHMO_0000228 a rdfs:Class ;
rdfs:label "spectroscopy" ;
rdfs:comment "The study of the interaction of a sample with radiation or particles for measurement or detection." ;
rdfs:subClassOf obo:OBI_0000070 .
obo:CHEBI_35664 a rdfs:Class ;
rdfs:label "EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor" ;
rdfs:comment "Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme." ;
rdfs:subClassOf obo:BFO_0000023 .
a rdfs:Class ;
rdfs:label "body weight" ;
rdfs:comment "The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms." ;
rdfs:subClassOf .
obo:PATO_0000033 a rdfs:Class ;
rdfs:label "concentration of" ;
rdfs:comment "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." ;
rdfs:subClassOf obo:PATO_0001241 .
a rdfs:Class ;
rdfs:label "insulin sensitivity measurement" ;
rdfs:comment "An insulin sensitivity measurement is a measurement of insulin metabolism, which can be measured in a number of ways, for example using the HOMA model or via a glucose tolerance test." ;
rdfs:subClassOf .
obo:BMONT_0000083 a rdfs:Class ;
rdfs:label "augmentation index" ;
rdfs:comment "Augmentation index is a measure of systemic arterial stiffness derived from the ascending aortic pressure waveform." ;
rdfs:subClassOf .
obo:GO_0008152 a rdfs:Class ;
rdfs:label "metabolic process" ;
rdfs:comment "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." ;
rdfs:subClassOf obo:GO_0008150 .
obo:DOID_4989 a rdfs:Class ;
rdfs:label "pancreatitis"@en ;
rdfs:comment "A pancreas disease that is characterized by inflammation of the pancreas."@en ;
rdfs:subClassOf obo:DOID_4 .
obo:NCIT_C41390 a rdfs:Class ;
rdfs:label "Negative Predictive Value of Diagnostic Test" ;
rdfs:comment "The probability that an individual is not affected with the condition when a negative test result is observed. This measure of accuracy should only be used if the data on the prevalence of condition of interest in given population is available. NPVDT can be determined by calculating: number of true negative results divided by the sum of true negative results plus number of false negative results." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:IAO_0000027 .
obo:CHEBI_24432 a rdfs:Class ;
rdfs:label "biological role" ;
rdfs:comment "A role played by the molecular entity or part thereof within a biological context." ;
rdfs:subClassOf obo:BFO_0000023 .
obo:DOID_0060903 a rdfs:Class ;
rdfs:label "thrombosis"@en ;
rdfs:comment "A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system."@en ;
rdfs:subClassOf obo:DOID_178 .
obo:BMONT_0000121 a rdfs:Class ;
rdfs:label "tau deposition" ;
rdfs:comment """Tau deposition refers to the accumulation of abnormal tau protein aggregates in the brain, which is a characteristic feature of several neurodegenerative disorders, including Alzheimer's disease (AD), frontotemporal dementia (FTD), and certain forms of Parkinson's disease (PD), among others.
In neuroimaging, techniques such as positron emission tomography (PET) using radioligands targeting tau can visualize and quantify tau deposition in the brain. These imaging methods enable researchers and clinicians to detect the presence of abnormal tau aggregates and assess their distribution and severity.""" ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:MONDO_0005311 a rdfs:Class ;
rdfs:label "atherosclerosis" ;
rdfs:comment "Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen." ;
rdfs:subClassOf obo:DOID_1287 .
obo:OMIT_0006913 a rdfs:Class ;
rdfs:label "Galvanic Skin Response" ;
rdfs:comment "A change in electrical resistance of the skin, occurring in emotion and in certain other conditions." ;
rdfs:subClassOf .
obo:PR_000003918 a rdfs:Class ;
rdfs:label "albumin" ;
rdfs:comment "A protein that is a translation product of the human ALB gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:OBI_0000070 a rdfs:Class ;
rdfs:label "assay"@en ;
rdfs:comment "A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies."@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:CMO_0003815 a rdfs:Class ;
rdfs:label "cerebral blood flow rate" ;
rdfs:comment "Cerebral blood flow (CBF) rate is the volume of blood delivered to or exiting the brain, through a network of cerebral arteries and veins, per unit time" ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BMONT_0000042 a rdfs:Class ;
rdfs:label "composite biomarkers" ;
rdfs:comment "Composite biomarkers, also known as multimarker panels or signatures, are combinations of multiple individual biomarkers that are used collectively to assess biological processes, disease states, or responses to treatments. These biomarkers can be diverse, including genetic, molecular, cellular, or clinical markers." ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:DOID_576 a rdfs:Class ;
rdfs:label "proteinuria" ;
rdfs:comment "A kidney disease that is characterized by the presence of excess proteins in the urine." ;
rdfs:subClassOf obo:DOID_557 .
a rdfs:Class ;
rdfs:label "antibody" ;
rdfs:comment "An antibody function (or antigen binding function) is an infection-fighting protein molecule in blood or secretory fluids that tags, neutralizes, and helps destroy pathogenic microorganisms such as bacteria, viruses and toxins." ;
rdfs:subClassOf obo:PR_000000001 .
obo:OBI_0302911 a rdfs:Class ;
rdfs:label "validation"@en ;
rdfs:comment "a planned process with objective to check that the accuracy or the quality of a claim or prediction satisfies some criteria and which is assessed by comparing with independent results"@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:BMONT_0000079 a rdfs:Class ;
rdfs:label "wearable" ;
rdfs:comment "Wearables are electronic devices that can be worn on the body, typically as accessories or clothing items, to provide functionality, collect data, and offer convenience and connectivity. These devices have gained popularity in recent years for their ability to track health metrics, provide notifications, and integrate with smartphones and other digital platforms, enhancing users' lifestyles and well-being." ;
rdfs:subClassOf obo:BMONT_0000078 .
obo:OPMI_0000446 a rdfs:Class ;
rdfs:label "immune biomarker"@en ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:CL_0000000 a rdfs:Class ;
rdfs:label "cell" ;
rdfs:comment "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." ;
rdfs:subClassOf obo:UBERON_0000465 .
obo:NCIT_C129416 a rdfs:Class ;
rdfs:label "MicroRNA 16" ;
rdfs:comment "A 22 ribonucleotide sequence that is a final product of the processing of either MIR16-1 pre-miRNA or MIR16-2 pre-miRNA. This oligonucleotide may be involved in the negative regulation of gene expression." ;
rdfs:subClassOf obo:SO_0000276 .
a rdfs:Class ;
rdfs:label "electrodermal activity measurement" ;
rdfs:comment "quantification of the change in the heat and electricity passed through the skin by nerves and sweat. Skin conduction increases in certain emotional states and during hot flashes that happen with menopause." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "FEV/FVC ratio" ;
rdfs:subClassOf .
obo:CHEBI_47774 a rdfs:Class ;
rdfs:label "low-density lipoprotein cholesterol" ;
rdfs:comment "Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL)." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:BFO_0000023 a rdfs:Class ;
rdfs:label "role"@en ;
rdfs:subClassOf obo:BFO_0000017 .
obo:NCIT_C17204 a rdfs:Class ;
rdfs:label "Computed Tomography" ;
rdfs:comment "A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis." ;
rdfs:subClassOf obo:NCIT_C17369 .
obo:BMONT_0000103 a rdfs:Class ;
rdfs:label "blood lipid level" ;
rdfs:comment "Blood lipid levels refer to the concentration of various lipid molecules in the blood. These lipids include cholesterol (including LDL cholesterol, HDL cholesterol, and total cholesterol) and triglycerides." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:NCIT_C175504 a rdfs:Class ;
rdfs:label "Smartphone" ;
rdfs:comment "A mobile cellular telephone that has an integrated computer with an operating system capable of web browsing and running downloaded applications. Smartphones typically have touchscreen interfaces, video calling capabilities, and other advanced built-in features and applications." ;
rdfs:subClassOf obo:BMONT_0000078 .
obo:BFO_0000027 a rdfs:Class ;
rdfs:label "object aggregate"@en ;
rdfs:subClassOf obo:BFO_0000040 .
obo:OMIT_0010388 a rdfs:Class ;
rdfs:label "Neoplastic Cells, Circulating" ;
rdfs:comment "Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors." ;
rdfs:subClassOf obo:CL_0000000 .
a rdfs:Class ;
rdfs:label "normal"@en ;
rdfs:comment "A quality that has a value that is normal or average."@en ;
rdfs:subClassOf .
obo:PR_000050469 a rdfs:Class ;
rdfs:label "hemoglobin A1c" ;
rdfs:comment "A hemoglobin complex that is composed of at least one beta-N-1-deoxy fructosyl hemoglobin subunit, in which the glycan is attached to the N-terminal valine (after initiator methionine removal) of one or both beta subunits." ;
rdfs:subClassOf obo:GO_0032991 .
obo:MONDO_0005113 a rdfs:Class ;
rdfs:label "bacterial infectious disease" ;
rdfs:comment "An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections." ;
rdfs:subClassOf obo:DOID_4 .
obo:DOID_3388 a rdfs:Class ;
rdfs:label "periodontal disease" ;
rdfs:comment "A mouth disease that is relating to or affecting the structures surrounding and supporting the teeth." ;
rdfs:subClassOf obo:MONDO_0005071 .
obo:BMONT_0000025 a rdfs:Class ;
rdfs:label "companion diagnostics" ;
rdfs:comment "When a biomarker test is designed to be used in conjunction with specific treatment, the test is known as a CDx. Safety and efficacy of the new drug and of the CDx are typically demonstrated in the same clinical trial for both the drug and the test." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:OBI_0000070 .
a rdfs:Class ;
rdfs:label "recombination measurement" ;
rdfs:comment "quantification of any recombination-related factor, such as hotspot usage, African enchrichment and recombination rate" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "functional connectivity decline"@en ;
rdfs:comment "Functional connectivity decline refers to a reduction in the coordinated activity or communication between different regions of the brain over time. It typically indicates weakened synchronization in neural signals, often observed in aging, neurodegenerative diseases (like Alzheimer’s), or brain injury. This decline can affect cognitive functions such as memory, attention, and executive processing." ;
rdfs:subClassOf obo:OBI_1110122 .
a rdfs:Class ;
rdfs:label "arterial stiffness measurement" ;
rdfs:comment "An Arterial stiffness measurement is the information output of a non invasive pulse wave velocity assay. Arterial stiffness is a predictor of cardiovascular mortality" ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:NCIT_C174446 a rdfs:Class ;
rdfs:label "Body Temperature" ;
rdfs:comment "A measurement of the temperature of the body." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:GO_0008150 a rdfs:Class ;
rdfs:label "biological_process" ;
rdfs:comment "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:BMONT_0000014 a rdfs:Class ;
rdfs:label "COX proportional hazards regression model" ;
rdfs:comment "The Cox proportional hazards regression model, often referred to as Cox regression or just proportional hazards model, is a statistical technique used to analyze the relationship between the survival time of subjects and predictor variables. It's commonly employed in survival analysis, a branch of statistics that deals with time-to-event data, such as time until death or time until recurrence of a disease." ;
rdfs:subClassOf obo:NCIT_C16866 .
a rdfs:Class ;
rdfs:label "gut microbiome measurement" ;
rdfs:comment "quantification of some aspect of an individual's micrbiome of the gut" ;
rdfs:subClassOf .
obo:STATO_0000416 a rdfs:Class ;
rdfs:label "precision"@en ;
rdfs:comment "precision or positive predictive value is defined as the proportion of the true positives against all the positive results (both true positives and false positives)"@en ;
rdfs:seeAlso ;
rdfs:subClassOf obo:IAO_0000027 .
a rdfs:Class ;
rdfs:label "skin microbiome measurement"@en ;
rdfs:comment "Quantification of some aspect of an individual's microbiome of the skin." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "aging"@en ;
rdfs:comment "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation." ;
rdfs:subClassOf obo:GO_0008150 .
obo:IDO_0000636 a rdfs:Class ;
rdfs:label "sepsis"@en ;
rdfs:comment "A process that is a systemic inflammatory response to infection."@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:NCIT_C201365 a rdfs:Class ;
rdfs:label "Pharmacodynamic Biomarker" ;
rdfs:comment "A response biomarker that indicates biologic activity of a medical product or environmental agent without necessarily drawing conclusions about efficacy or disease outcome or necessarily linking this activity to an established mechanism of action. (NIH-FDA BEST (Biomarkers, Endpoints, and other Tools) Resource)" ;
rdfs:subClassOf obo:NCIT_C201303 .
a rdfs:Class ;
rdfs:label "mosaic loss of chromosome Y measurement" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "tumor necrosis factor-alpha" ;
rdfs:comment "Tumor necrosis factor (TNF, cachexin or cachectin formerly known as tumor necrosis factor-alpha or TNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by other cell types as well." ;
rdfs:subClassOf .
obo:NCIT_C120540 a rdfs:Class ;
rdfs:label "Pupillometry" ;
rdfs:comment "A technique used to measure the diameter of the pupil in response to stimuli." ;
rdfs:subClassOf .
obo:BMONT_0000053 a rdfs:Class ;
rdfs:label "stratification biomarker" ;
rdfs:comment "A stratification biomarker is a biological characteristic or measurement used to categorize individuals into different subgroups based on their likelihood of responding to a particular treatment or exhibiting certain disease characteristics. These biomarkers are especially valuable in the context of personalized or precision medicine, where treatments can be tailored to individual patients based on their unique characteristics." ;
rdfs:subClassOf obo:OPMI_0000445 .
a rdfs:Class ;
rdfs:label "systolic blood pressure" ;
rdfs:comment "The blood pressure during the contraction of the left ventricle of the heart." ;
rdfs:subClassOf .
obo:BFO_0000016 a rdfs:Class ;
rdfs:label "disposition"@en ;
rdfs:subClassOf obo:BFO_0000017 .
obo:MAXO_0000003 a rdfs:Class ;
rdfs:label "diagnostic procedure"@en ;
rdfs:comment "Any procedure or test to diagnose a disease or disorder." ;
rdfs:subClassOf obo:MAXO_0000001 .
obo:IAO_0000030 a rdfs:Class ;
rdfs:label "information content entity"@en ;
rdfs:comment "A generically dependent continuant that is about some thing."@en ;
rdfs:subClassOf obo:BFO_0000031 .
obo:BMONT_0000137 a rdfs:Class ;
rdfs:label "mitochondrial function"@en ;
rdfs:comment "Mitochondrial function refers to the various vital processes performed by mitochondria, which are the energy-producing organelles in cells." ;
rdfs:subClassOf obo:GO_0008152 .
obo:NCIT_C38101 a rdfs:Class ;
rdfs:label "X-Ray Imaging" ;
rdfs:comment "A radiographic procedure using the emission of x-rays to form an image of the structure penetrated by the radiation." ;
rdfs:subClassOf obo:NCIT_C17369 .
a rdfs:Class ;
rdfs:label "amyloid deposition measurement" ;
rdfs:comment "quantification of some aspect of the deposition of amyloid proteins in an organ" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "nighttime rest measurement" ;
rdfs:comment "quantification of some aspect of nighttime rest such as duration or quality" ;
rdfs:subClassOf .
obo:PR_000011426 a rdfs:Class ;
rdfs:label "neurogranin" ;
rdfs:comment "A protein that is a translation product of the human NRGN gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
a rdfs:Class ;
rdfs:label "regenerative capacity"@en ;
rdfs:comment "Regenerative capacity is a complex trait dependent on the ability to access high-fidelity morphogenetic programmes after injury. It is distributed unequally among species and, within individuals, among their tissues." ;
rdfs:subClassOf obo:MI_0252 .
obo:NCIT_C15367 a rdfs:Class ;
rdfs:label "Risk Assessment" ;
rdfs:comment "An estimated probability that one or more adverse event(s) will occur as a result of exposure to an actual or potential hazardous situation or chemical." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:OBI_0000673 a rdfs:Class ;
rdfs:label "statistical hypothesis test"@en ;
rdfs:comment "A statistical hypothesis test data transformation is a data transformation that has objective statistical hypothesis test."@en ;
rdfs:subClassOf obo:GSSO_012786 .
a rdfs:Class ;
rdfs:label "malignant" ;
rdfs:comment "Refers to abnormal cell activity manifested by decreased control over growth and function, causing tumor growth or spread into surrounding tissue and adverse effects to the host" ;
rdfs:subClassOf obo:BFO_0000019 .
obo:ICO_0000233 a rdfs:Class ;
rdfs:label "regulatory document"@en ;
rdfs:comment "A document that either prescribes actions or prescribes the permissions, obligations, restrictions, or protections relating to public or legal policy."@en ;
rdfs:subClassOf obo:NCIT_C19498 .
a rdfs:Class ;
rdfs:label "endothelial dysfunction" ;
rdfs:comment "In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium (the inner lining of blood vessels) and can be broadly defined as an imbalance between vasodilating and vasoconstricting substances produced by (or acting on) the endothelium. Normal functions of endothelial cells include mediation of coagulation, platelet adhesion, immune function and control of volume and electrolyte content of the intravascular and extravascular spaces." ;
rdfs:subClassOf obo:DOID_1287 .
a rdfs:Class ;
rdfs:label "maximal voluntary ventilation" ;
rdfs:comment "Qunatification of the maximum volume of air that an organism can breathe in and out during a specified period of time, often 1 minute." ;
rdfs:subClassOf .
obo:OMIT_0036840 a rdfs:Class ;
rdfs:label "AKR1C3" ;
rdfs:comment "aldo-keto reductase family 1, member C3" ;
rdfs:subClassOf obo:OGG_0000000002 .
a rdfs:Class ;
rdfs:label "voice analysis" ;
rdfs:comment "The process of examining the acoustic properties of a person's voice to extract meaningful information. This can include pitch, tone, volume, speech patterns, and other vocal features." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:BMONT_0000085 a rdfs:Class ;
rdfs:label "stiffness index" ;
rdfs:comment "The stiffness index (SI) derived from the analysis of digital volume pulse (DVP) is a noninvasive indirect technique of measuring arterial stiffness peripherally." ;
rdfs:subClassOf .
obo:NCIT_C2902 a rdfs:Class ;
rdfs:label "Coagulation Disorder" ;
rdfs:comment "A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood." ;
rdfs:subClassOf obo:DOID_4 .
obo:ADO_0000090 a rdfs:Class ;
rdfs:label "total tau" ;
rdfs:comment "A protein that is regarded as a general marker of neurodegeneration for evaluation in future population-based studies and represents the total tau concentration in a given sample." ;
rdfs:subClassOf obo:PR_000000001 .
a rdfs:Class ;
rdfs:label "age estimator"@en ;
rdfs:comment "A computational or biological tool, model, or marker used to estimate the chronological or biological age of an organism based on measurable features such as genetic, epigenetic, physiological, or imaging data." ;
rdfs:subClassOf obo:NCIT_C16866 .
a rdfs:Class ;
rdfs:label "stem cell quantity"@en ;
rdfs:comment "The decline in stem cell function is a well-established feature of the aging process and plays a crucial role in the overall degeneration of tissues and organs as we age. Stem cells are responsible for tissue regeneration, repair, and maintaining homeostasis in the body. As we age, the function of these stem cells diminishes, leading to impaired tissue repair, reduced regeneration capacity, and an increased risk of age-related diseases." ;
rdfs:subClassOf obo:MI_0252 .
obo:NCIT_C16810 a rdfs:Class ;
rdfs:label "Magnetic Resonance Spectroscopy" ;
rdfs:comment "Detection and measurement of the resonant spectra of molecular species in a tissue or sample." ;
rdfs:subClassOf obo:NCIT_C16809 .
obo:DOID_0014667 a rdfs:Class ;
rdfs:label "disease of metabolism" ;
rdfs:comment "A disease that involving errors in metabolic processes of building or degradation of molecules." ;
rdfs:subClassOf obo:DOID_4 .
obo:BMONT_0000110 a rdfs:Class ;
rdfs:label "cerebral blood volume" ;
rdfs:comment "Cerebral blood volume (CBV) is one of the parameters generated by perfusion techniques (CT perfusion and MR perfusion). CBV is defined as the volume of blood in a given amount of brain tissue, most commonly milliliters of blood per 100 g of brain tissue." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BFO_0000001 a rdfs:Class ;
rdfs:label "entity"@en .
obo:CHEBI_18059 a rdfs:Class ;
rdfs:label "lipid" ;
rdfs:comment "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:NCIT_C16199 a rdfs:Class ;
rdfs:label "Cancer Research" ;
rdfs:comment "Systematic investigation into the causes of cancer and development of strategies for prevention, diagnosis, treatment, and cure." ;
rdfs:subClassOf obo:OBI_0000011 .
a rdfs:Class ;
rdfs:label "parameter"@en ;
rdfs:comment "A parameter is variable whose value changes the characteristics of a system or a function."@en ;
rdfs:subClassOf obo:IAO_0000030 .
a rdfs:Class ;
rdfs:label "handgrip strength"@en ;
rdfs:comment "Handgrip strength (HGS) is a simple and reliable measurement of maximum voluntary muscle strength. It is an important tool for diagnosing sarcopenia and is widely used as a single indicator to represent overall muscle strength. HGS can predict not only muscle mass and physical activity, but also the incidence of chronic diseases, nutritional status, quality of life, independence of daily life, length of hospital stay, and even mortality." ;
rdfs:subClassOf .
obo:BMONT_0000008 a rdfs:Class ;
rdfs:label "target biomarker" ;
rdfs:comment "A biomarker that reports interaction of the drug with its target" ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:BFO_0000026 a rdfs:Class ;
rdfs:label "one-dimensional spatial region"@en ;
rdfs:subClassOf obo:BFO_0000006 .
obo:OPMI_0000457 a rdfs:Class ;
rdfs:label "diagnostic biomarker"@en ;
rdfs:comment "A biomarker that can serve a role in narrowing down diagnosis, which can lead to diagnosis that is significantly more specific to individual patients." ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:BMONT_0000088 a rdfs:Class ;
rdfs:label "distance walked" ;
rdfs:comment "Distance walked is a straightforward and important metric that reflects the total length covered by an individual during a specified period, typically measured in meters or miles. This metric is widely used in various fields, including healthcare, fitness, sports, and rehabilitation, to assess physical activity levels, mobility, and overall health." ;
rdfs:subClassOf obo:BMONT_0000086 .
obo:MAXO_0000972 a rdfs:Class ;
rdfs:label "eye movement measurement"@en ;
rdfs:comment "Assessment of the parameters of eye movement, including horizontal and vertical rotations of the eye, opening or closing of the eyes in response to stimuli, pupil response to light, and blink reflex." ;
rdfs:subClassOf .
obo:PR_000005897 a rdfs:Class ;
rdfs:label "C-reactive protein" ;
rdfs:comment "A protein that is a translation product of the human CRP gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:CHEBI_23965 a rdfs:Class ;
rdfs:label "estradiol" ;
rdfs:comment "A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17." ;
rdfs:subClassOf obo:CHEBI_35341 .
obo:BMONT_0000034 a rdfs:Class ;
rdfs:label "Pharmacogenetic Tests and Genetic Tests for Heritable Markers Guidance for Industry and FDA Staff" ;
rdfs:comment "The guidance document is intended to facilitate progress in the field of pharmacogenomics and genetics by helping to shorten development and review timelines, facilitate rapid transfer of new technology from the research bench to the clinical diagnostic laboratory, and encourage informed use of pharmacogenomic and genetic diagnostic devices. It provides recommendations to sponsors and FDA reviewers in preparing and reviewing premarket approval applications (PMA) and premarket notification (510(k)) submissions for pharmacogenetic and other human genetic tests, whether testing is for single markers or for multiple markers simultaneously (multiplex tests). Array-based tests (commonly referred to as microarrays) are a subset of multiplex tests and are included in the scope of this document. The recommendations within this guidance for elements of a genetic test submission apply to pharmacogenetic (e.g., drug-metabolizing enzyme allele tests, single nucleotide polymorphism (SNP) analysis) and other types of genetic tests. Tests of gene expression and tests for non-heritable (somatic) mutations are not specifically addressed, although many of the same principles may apply. In addition, this guidance considers nucleic acid-based analysis only, but the principles may be applied to other matrices (e.g., protein) when the purpose is to provide genetic information." ;
rdfs:seeAlso , , ;
rdfs:subClassOf obo:ICO_0000233 .
obo:BFO_0000004 a rdfs:Class ;
rdfs:label "independent continuant"@en ;
rdfs:comment "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
rdfs:subClassOf obo:BFO_0000002 .
a rdfs:Class ;
rdfs:label "phenotypic age"@en ;
rdfs:comment "Phenotypic age refers to an individual’s biological age, which is determined by their physical characteristics and functioning rather than their chronological age" ;
rdfs:subClassOf obo:PATO_0000011 .
obo:OBI_0000169 a rdfs:Class ;
rdfs:label "placebo role"@en ;
rdfs:comment "a negative reference substance is a reference role in which the substance playing the reference substance role is physically similar in appearance to the test substance" ;
rdfs:subClassOf obo:BFO_0000023 .
obo:PATO_0000044 a rdfs:Class ;
rdfs:label "frequency" ;
rdfs:comment "A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time." ;
rdfs:subClassOf .
obo:OMIT_0028283 a rdfs:Class ;
rdfs:label "Carcinogenesis" ;
rdfs:comment "The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years." ;
rdfs:subClassOf obo:MONDO_0005070 .
a rdfs:Class ;
rdfs:label "Crohn's disease" ;
rdfs:comment "A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients." ;
rdfs:subClassOf obo:DOID_0050589 .
obo:CL_0000094 a rdfs:Class ;
rdfs:label "granulocyte" ;
rdfs:comment "A leukocyte with abundant granules in the cytoplasm." ;
rdfs:subClassOf obo:CL_0000738 .
obo:DOID_6713 a rdfs:Class ;
rdfs:label "cerebrovascular disease" ;
rdfs:comment "An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain." ;
rdfs:subClassOf obo:DOID_4 .
a rdfs:Class ;
rdfs:label "NT-proBNP measurement" ;
rdfs:comment "Is a quantification of NT-proBNP (N-terminal prohormone of brain natriuretic peptide) which is associated with acute congestive heart failure." ;
rdfs:subClassOf .
obo:BMONT_0000068 a rdfs:Class ;
rdfs:label "biomarker repurposing" ;
rdfs:comment "Biomarker repurposing, the novel application of existing biomarkers for other purposes." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:OGMS_0000093 a rdfs:Class ;
rdfs:label "prognosis" ;
rdfs:comment "A hypothesis about some future part of a disease course."@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:CMO_0000907 a rdfs:Class ;
rdfs:label "renal blood flow rate" ;
rdfs:comment "Renal blood flow (RBF) is the volume of blood delivered to or exiting from the kidneys per unit time." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:OMIT_0043247 a rdfs:Class ;
rdfs:label "WWC3" ;
rdfs:comment "WWC family member 3" ;
rdfs:subClassOf obo:OGG_0000000002 .
a rdfs:Class ;
rdfs:label "brain aging"@en ;
rdfs:comment "Brain aging is a complex process that affects everything from the subcellular to the organ level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily characterized by brain volume loss, cortical thinning, white matter degradation, loss of gyrification, and ventricular enlargement. Pathophysiologically, brain aging is associated with neuron cell shrinking, dendritic degeneration, demyelination, small vessel disease, metabolic slowing, microglial activation, and the formation of white matter lesions." ;
rdfs:subClassOf .
obo:BFO_0000146 a rdfs:Class ;
rdfs:label "two-dimensional continuant fiat boundary"@en ;
rdfs:subClassOf obo:BFO_0000140 .
a rdfs:Class ;
rdfs:label "tumor size" ;
rdfs:comment "The physical size of a tumor." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BMONT_0000093 a rdfs:Class ;
rdfs:label "gait analysis" ;
rdfs:comment "Determination of the level of functional limitation that may be due to pathology, and evaluating rehabilitative intervention of the way in which the body moves from one point to another. Most often, this is done by walking." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:BFO_0000015 a rdfs:Class ;
rdfs:label "process"@en ;
rdfs:comment "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
rdfs:subClassOf obo:BFO_0000003 .
a rdfs:Class ;
rdfs:label "pace of aging computed from the epigenome"@en ;
rdfs:comment "Pace of Aging Computed from the Epigenome is a biomarker developed to assess the biological aging process based on DNA methylation patterns. Unlike other aging measures that focus on chronological age, DunedinPACE specifically evaluates how quickly or slowly an individual is aging by analyzing chemical tags (methylation marks) on DNA in white blood cells." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:OBI_0400147 a rdfs:Class ;
rdfs:label "microarray" ;
rdfs:comment "A processed material that is made to be used in an analyte assay. It consists of a physical immobilisation matrix in which substances that bind the analyte are placed in regular spatial position." ;
rdfs:subClassOf obo:OBI_0000968 .
a rdfs:Class ;
rdfs:label "inflammatory biomarker measurement" ;
rdfs:comment "Is a quantification of any molecule involved in the process of inflammatory response." ;
rdfs:subClassOf .
obo:NCIT_C94416 a rdfs:Class ;
rdfs:label "Sleep Stage" ;
rdfs:subClassOf .
obo:PR_000005423 a rdfs:Class ;
rdfs:label "chitinase-3-like protein 1" ;
rdfs:comment "A protein that is a translation product of the human CHI3L1 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
a rdfs:Class ;
rdfs:label "genetic variation" ;
rdfs:comment "The genetic variation of individuals in a population." ;
rdfs:subClassOf .
obo:OMIT_0020024 a rdfs:Class ;
rdfs:label "Natriuretic Peptide, Brain" ;
rdfs:comment "A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS." ;
rdfs:subClassOf obo:CHEBI_16670 .
obo:BMONT_0000122 a rdfs:Class ;
rdfs:label "mean diffusivity" ;
rdfs:comment """Mean diffusivity (MD) is a metric derived from diffusion-weighted magnetic resonance imaging (DW-MRI) data. It quantifies the average magnitude of water molecule diffusion within a particular tissue or region of interest.
MD is calculated based on the diffusion tensor, which characterizes the rate and directionality of water diffusion in tissue. Unlike fractional anisotropy (FA), which measures the degree of diffusion directionality, MD represents the overall magnitude of diffusion regardless of direction.""" ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:MONDO_0005070 a rdfs:Class ;
rdfs:label "neoplasm" ;
rdfs:comment "A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias." ;
rdfs:subClassOf obo:DOID_162 .
a rdfs:Class ;
rdfs:label "thyroid disease" ;
rdfs:comment "A thyroid disease is a medical condition impairing the function of the thyroid. Different thyroid diseases include Hashimoto's thyroiditis, hyperthyroidism and hypothyroidism. These diseases have a large range of symptoms and affect all ages." ;
rdfs:subClassOf obo:DOID_4 .
obo:DOID_162 a rdfs:Class ;
rdfs:label "cancer" ;
rdfs:comment "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." ;
rdfs:subClassOf obo:DOID_4 .
obo:BMONT_0000046 a rdfs:Class ;
rdfs:label "biomarker qualification" ;
rdfs:comment "Qualification is the evidentiary process of linking a biomarker with biological processes and clinical end points." ;
rdfs:subClassOf obo:OBI_0000011 .
a rdfs:Class ;
rdfs:label "genomic measurement" ;
rdfs:comment "Is a quantification of some aspect of the genome, e.g. copy number variation at some locus." ;
rdfs:subClassOf .
obo:BMONT_0000116 a rdfs:Class ;
rdfs:label "blood oxygen level-dependent signal" ;
rdfs:comment "The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects changes in deoxyhemoglobin driven by localized changes in brain blood flow and blood oxygenation, which are coupled to underlying neuronal activity by a process termed neurovascular coupling." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BMONT_0000114 a rdfs:Class ;
rdfs:label "tissue attenuation coefficient" ;
rdfs:comment "The attenuation coefficient is a measure of how much the incident energy beam (e.g. ultrasound or x-rays) is weakened by the material it is passing through." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:OMIT_0012292 a rdfs:Class ;
rdfs:label "Probability" ;
rdfs:comment "The study of chance processes or the relative frequency characterizing a chance process." ;
rdfs:subClassOf .
obo:OBCS_0000025 a rdfs:Class ;
rdfs:label "univariate analysis" ;
rdfs:comment "An inferential statistical data analysis that has only one independent variable" ;
rdfs:subClassOf obo:GSSO_012786 .
a rdfs:Class ;
rdfs:label "proteomic clock"@en ;
rdfs:comment "A proteomic aging clock is a biological tool that estimates an individual's biological age based on the levels of specific proteins in the body. These proteins serve as biomarkers of aging, reflecting underlying processes such as inflammation, metabolism, immune function, and cellular repair mechanisms." ;
rdfs:subClassOf .
obo:BMONT_0000127 a rdfs:Class ;
rdfs:label "gait speed" ;
rdfs:comment "Gait speed, also known as walking speed, is a crucial parameter in the study of human locomotion and biomechanics. It is defined as the distance covered per unit of time while walking. Gait speed is often measured in meters per second (m/s) or feet per second (ft/s) and is an important indicator of overall health, functional status, and mobility." ;
rdfs:seeAlso ;
rdfs:subClassOf .
obo:MONDO_0005002 a rdfs:Class ;
rdfs:label "chronic obstructive pulmonary disease" ;
rdfs:comment "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema." ;
rdfs:subClassOf obo:DOID_850 .
obo:CHEBI_64645 a rdfs:Class ;
rdfs:label "amyloid-beta" ;
rdfs:comment "A peptide of 36-43 amino acids that is processed from the amyloid precursor protein. Appears to be the main constituent of amyloid plaques (deposits found in the brains of Alzheimer's disease patients)." ;
rdfs:subClassOf obo:CHEBI_16670 .
obo:PR_000009758 a rdfs:Class ;
rdfs:label "leptin" ;
rdfs:comment "A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:UBERON_0002416 a rdfs:Class ;
rdfs:label "integumental system" ;
rdfs:comment "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." ;
rdfs:subClassOf obo:UBERON_0000467 .
obo:MONDO_0005381 a rdfs:Class ;
rdfs:label "bone disorder" ;
rdfs:comment "Diseases of bones." ;
rdfs:subClassOf obo:OGMS_0000045 .
obo:NCIT_C100433 a rdfs:Class ;
rdfs:label "Kidney Injury Molecule-1 Measurement" ;
rdfs:comment "The determination of the amount of kidney injury molecule-1 present in a sample." ;
rdfs:subClassOf .
obo:OMIT_0030323 a rdfs:Class ;
rdfs:label "ARG1" ;
rdfs:comment "arginase 1" ;
rdfs:subClassOf obo:OGG_0000000002 .
a rdfs:Class ;
rdfs:label "process quality"@en ;
rdfs:comment "A process quality is quality that is associated with a process."@en ;
rdfs:subClassOf obo:BFO_0000019 .
obo:BFO_0000009 a rdfs:Class ;
rdfs:label "two-dimensional spatial region"@en ;
rdfs:subClassOf obo:BFO_0000006 .
obo:BFO_0000028 a rdfs:Class ;
rdfs:label "three-dimensional spatial region"@en ;
rdfs:subClassOf obo:BFO_0000006 .
a rdfs:Class ;
rdfs:label "cross sectional design" ;
rdfs:comment "A study in which participants are examined at only a single time for characteristics of a disease." ;
rdfs:subClassOf obo:CTO_0000220 .
obo:CHEBI_23367 a rdfs:Class ;
rdfs:label "molecular entity" ;
rdfs:comment "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." ;
rdfs:subClassOf obo:CHEBI_24431 .
obo:SYMP_0000462 a rdfs:Class ;
rdfs:label "symptom" ;
rdfs:comment "A symptom is a perceived change in function, sensation, loss, disturbance or appearance reported by a patient indicative of a disease." ;
rdfs:subClassOf obo:BFO_0000017 .
obo:OBI_1110122 a rdfs:Class ;
rdfs:label "pathologic process"@en ;
rdfs:comment "abnormal, harmful processes caused by or associated with a disease"@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:CMO_0000000 a rdfs:Class ;
rdfs:label "clinical measurement" ;
rdfs:comment "A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation." ;
rdfs:subClassOf .
obo:OBI_0001986 a rdfs:Class ;
rdfs:label "immunohistochemistry" ;
rdfs:comment "An immunostaining assay to detect and potentially localize antigens within the cells of a tissue section." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:CHEBI_24431 a rdfs:Class ;
rdfs:label "chemical entity" ;
rdfs:comment "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." ;
rdfs:subClassOf obo:BFO_0000030 .
obo:BFO_0000142 a rdfs:Class ;
rdfs:label "one-dimensional continuant fiat boundary"@en ;
rdfs:subClassOf obo:BFO_0000140 .
a rdfs:Class ;
rdfs:label "decreased"@en ;
rdfs:comment "A quality that has a value that is decreased compared to normal or average."@en ;
rdfs:subClassOf .
obo:ONS_0000098 a rdfs:Class ;
rdfs:label "susceptibility biomarker"@en ;
rdfs:comment "Measurable indicator including genetic or acquired host factors and intrinsic factors, influencing the response of an individual to a (dietary) exposure." ;
rdfs:subClassOf obo:OPMI_0000445 .
a rdfs:Class ;
rdfs:label "sleep efficiency"@en ;
rdfs:comment "A relative measurement of the time spent asleep to the total time spent in bed." ;
rdfs:subClassOf .
obo:BMONT_0000108 a rdfs:Class ;
rdfs:label "myelin water fraction" ;
rdfs:comment "The myelin water fraction (MWF) is defined as the ratio of the myelin water signal (15 ms < T2 < 40 ms) to the total water signal and correlates strongly with histological staining for myelin." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:MPATH_0 a rdfs:Class ;
rdfs:label "pathological entity" ;
rdfs:comment "Pathological structure or process" ;
rdfs:subClassOf obo:BFO_0000004 .
obo:BMONT_0000019 a rdfs:Class ;
rdfs:label "clinical validation" ;
rdfs:comment "Clinical validation aims to establish an association between the biomarker and the endpoint of interest and to demonstrate the usefulness of the biomarker. Clinical validation relies on external validation and can be done by retrospective use of clinical trial data or by prospective clinical trials. Retrospective use of clinical trial data is a form of external clinical validation where the biomarker evaluation is not part of the original study design." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:BMONT_0000017 .
obo:OMIT_0026290 a rdfs:Class ;
rdfs:label "Growth Differentiation Factor 15" ;
rdfs:comment "A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration." ;
rdfs:subClassOf .
obo:PATO_0001818 a rdfs:Class ;
rdfs:label "progressive" ;
rdfs:comment "A quality of a single process inhering in a bearer by virtue of the bearer's increasing over time." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "lipoprotein A measurement" ;
rdfs:comment "quantification of some lipoprotein A in a sample" ;
rdfs:subClassOf .
obo:NCIT_C64862 a rdfs:Class ;
rdfs:label "Diffusion Tensor Imaging" ;
rdfs:comment "A type of diffusion-weighted magnetic resonance imaging (DW-MRI) that maps the diffusion of water in three dimensions, the principal purpose of which is to image the white matter of the brain, specifically measuring the anisotropy, location, and orientation of the neural tracts, which can demonstrate microstructural changes or differences with neuropathology and treatment." ;
rdfs:subClassOf obo:NCIT_C16809 .
obo:NCIT_C28378 a rdfs:Class ;
rdfs:label "Proliferation" ;
rdfs:comment "Multiplying or increasing in number." ;
rdfs:subClassOf obo:GO_0008150 .
obo:PR_000009725 a rdfs:Class ;
rdfs:label "neutrophil gelatinase-associated lipocalin" ;
rdfs:comment "A protein that is a translation product of the human LCN2 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:NCIT_C122778 a rdfs:Class ;
rdfs:label "Creatine Kinase MB" ;
rdfs:comment "An isoenzyme complex comprised of a heterodimer of creatine kinase M-type and B-type." ;
rdfs:subClassOf obo:GO_0032991 .
a rdfs:Class ;
rdfs:label "vital capacity" ;
rdfs:comment "The volume of air that is exhaled by a maximal expiration following a maximal inspiration." ;
rdfs:subClassOf .
obo:NCIT_C88227 a rdfs:Class ;
rdfs:label "Serum Creatinine Assay" ;
rdfs:comment "A laboratory test used for the measurement of creatinine levels in the serum to determine the glomerular filtration rate." ;
rdfs:subClassOf obo:OBI_0000070 .
obo:PR_000016509 a rdfs:Class ;
rdfs:label "troponin T, cardiac muscle" ;
rdfs:comment "A protein that is a translation product of the human TNNT2 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:UBERON_0016446 a rdfs:Class ;
rdfs:label "hair of head" ;
rdfs:comment "A strand of hair that is part of a head." ;
rdfs:subClassOf obo:UBERON_0002416 .
obo:OBI_0000011 a rdfs:Class ;
rdfs:label "planned process"@en ;
rdfs:comment "A process that realizes a plan which is the concretization of a plan specification."@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:DOID_3082 a rdfs:Class ;
rdfs:label "interstitial lung disease" ;
rdfs:comment "A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough." ;
rdfs:subClassOf obo:DOID_850 .
obo:DOID_10763 a rdfs:Class ;
rdfs:label "hypertension" ;
rdfs:comment "An artery disease characterized by chronic elevated blood pressure in the arteries." ;
rdfs:subClassOf obo:DOID_4 .
obo:DOID_14499 a rdfs:Class ;
rdfs:label "Fabry disease" ;
rdfs:comment "A sphingolipidosis that is characterized by the buildup of globotriaosylceramide in the body's cells and has_material_basis_in X-linked inherited mutations in the GLA gene, encoding alpha-galactosidase A, on chromosome Xq22." ;
rdfs:subClassOf .
obo:STATO_0000412 a rdfs:Class ;
rdfs:label "prevalence"@en ;
rdfs:comment "prevalence is a ratio formed by the number of subjects diagnosed with a disease divided by the total population size."@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:BFO_0000002 a rdfs:Class ;
rdfs:label "continuant"@en ;
rdfs:subClassOf obo:BFO_0000001 .
a rdfs:Class ;
rdfs:label "metabolic syndrome" ;
rdfs:comment "A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)" ;
rdfs:subClassOf obo:DOID_0014667 .
a rdfs:Class ;
rdfs:label "hippocampal volume" ;
rdfs:comment "Measurement of the volume of the hippocampus" ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BMONT_0000095 a rdfs:Class ;
rdfs:label "blood volume pulse" ;
rdfs:comment "Photoplethysmographic blood volume pulse (BVP) is a noninvasive sensor and is used to measure blood volume changes and vasodilator function in the microvessels of the finger. BVP is widely used to detect the peripheral pulse waveform that is converted to blood volume amplitude (BVA). Blood volume amplitude reflects arterial dilation and contraction that are controlled by the autonomic nervous system (ANS)." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BMONT_0000021 a rdfs:Class ;
rdfs:label "clinical specificity" ;
rdfs:comment "Specificity of the biomarker, referred to as the ability of a biomarker or a change in biomarker to distinguish patients who are responders to an intervention from those who are non-responders in terms of changes in clinical endpoints." ;
rdfs:subClassOf .
obo:DOID_114 a rdfs:Class ;
rdfs:label "heart disease" ;
rdfs:comment "A cardiovascular system disease that involves the heart." ;
rdfs:subClassOf obo:DOID_4 .
obo:CTO_0000220 a rdfs:Class ;
rdfs:label "clinical trial"@en ;
rdfs:comment "a clinical trial is a medical interventional study where participants are assigned prospectively to an intervention or interventions according to a protocol to evaluate the safety and efficacy of the intervention(s) on biomedical or other health related outcomes. The Interventions include but are not restricted to drugs, cells and other biological products, surgical procedures, radiologic procedures, devices, behavioral treatments, process-of-care changes, preventive care, etc." ;
rdfs:subClassOf obo:OBI_0000011 .
a rdfs:Class ;
rdfs:label "sleep latency" ;
rdfs:comment "amount of time, usually recorded in minutes, between going to bed and falling asleep" ;
rdfs:subClassOf .
obo:BMONT_0000010 a rdfs:Class ;
rdfs:label "staging biomarker" ;
rdfs:comment "A biomarker that distinguishes between different stages of chronic disease." ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:CHEBI_17855 a rdfs:Class ;
rdfs:label "triglyceride" ;
rdfs:comment "Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:BFO_0000008 a rdfs:Class ;
rdfs:label "temporal region"@en ;
rdfs:subClassOf obo:BFO_0000003 .
a rdfs:Class ;
rdfs:label "correlation"@en ;
rdfs:comment "A correlation is a statistical relationship involving dependence between two random variables or datasets."@en ;
rdfs:subClassOf .
obo:NCIT_C106407 a rdfs:Class ;
rdfs:label "MicroRNA 124" ;
rdfs:comment "A 20 ribonucleotide sequence that is a final product of the processing of either MIR124-1 pre-miRNA, MIR124-2 pre-miRNA or MIR124-3 pre-miRNA. This oligonucleotide may be involved in the negative regulation of gene expression." ;
rdfs:subClassOf obo:SO_0000276 .
obo:OBCS_0000023 a rdfs:Class ;
rdfs:label "multivariate analysis" ;
rdfs:comment "An inferential statistical data analysis that is used to analyze data that arises from more than one variable" ;
rdfs:subClassOf obo:GSSO_012786 .
obo:PATO_0000085 a rdfs:Class ;
rdfs:label "sensitivity toward" ;
rdfs:comment "A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation." ;
rdfs:subClassOf obo:PATO_0001241 .
obo:MP_0005331 a rdfs:Class ;
rdfs:label "insulin resistance" ;
rdfs:comment "diminished effectiveness of insulin in lowering plasma glucose levels" ;
rdfs:subClassOf obo:SYMP_0000462 .
a rdfs:Class ;
rdfs:label "biological age"@en ;
rdfs:comment "Biological age is a measure of health that offers insights into ageing." ;
rdfs:subClassOf obo:PATO_0000011 .
obo:BMONT_0000090 a rdfs:Class ;
rdfs:label "active minute" ;
rdfs:comment "Active minutes refer to the total duration of physical activity during which an individual engages in moderate to vigorous intensity exercise. This metric is commonly used to track and quantify the amount of time spent being physically active, providing insight into one's overall activity level and adherence to recommended exercise guidelines." ;
rdfs:subClassOf obo:BMONT_0000086 .
obo:UBERON_0000467 a rdfs:Class ;
rdfs:label "anatomical system" ;
rdfs:comment "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." ;
rdfs:seeAlso obo:EHDAA2_0001330 ;
rdfs:subClassOf obo:UBERON_0000061 .
a rdfs:Class ;
rdfs:label "recombination rate" ;
rdfs:comment "Is the genome wide recombination rate." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "mosaic loss of chromosome X measurement"@en ;
rdfs:comment "It is the most common clonal somatic alteration in leukocytes of female individuals." ;
rdfs:subClassOf .
obo:BMONT_0000026 a rdfs:Class ;
rdfs:label "complementary diagnostics" ;
rdfs:comment "Complementary diagnostics are tests that, although not needed for the prescription of the corresponding therapeutic product, provide useful information on the drug risk/benefit in specific patient subsets" ;
rdfs:subClassOf obo:OBI_0000070 .
a rdfs:Class ;
rdfs:label "oral microbiome measurement"@en ;
rdfs:comment "Quantification of some aspect of an individual's oral microbiome." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "daytime rest measurement" ;
rdfs:comment "quantification of some aspect of daytime rest such as duration, frequency or quality" ;
rdfs:subClassOf .
obo:OMIT_0019447 a rdfs:Class ;
rdfs:label "Ki-67 Antigen" ;
rdfs:comment """definition
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.""" ;
rdfs:subClassOf obo:PR_000000001 .
obo:UBERON_0000061 a rdfs:Class ;
rdfs:label "anatomical structure" ;
rdfs:comment "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." ;
rdfs:subClassOf obo:UBERON_0000465 .
obo:DOID_409 a rdfs:Class ;
rdfs:label "liver disease" ;
rdfs:subClassOf obo:DOID_4 .
obo:CL_0000775 a rdfs:Class ;
rdfs:label "neutrophil" ;
rdfs:comment "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." ;
rdfs:subClassOf obo:CL_0000094 .
a rdfs:Class ;
rdfs:label "mathematical entity"@en ;
rdfs:comment "A mathematical entity is an information content entity that are components of a mathematical system or can be defined in mathematical terms."@en ;
rdfs:subClassOf obo:IAO_0000030 .
obo:MAXO_0000002 a rdfs:Class ;
rdfs:label "therapeutic procedure"@en ;
rdfs:comment "All manners of treatment, be they pharmaceuticals, invasive procedures, etc. to relieve illness and injury in attempts to bring the body back to its normal state." ;
rdfs:subClassOf obo:MAXO_0000001 .
obo:DOID_2355 a rdfs:Class ;
rdfs:label "anemia" ;
rdfs:comment "A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells." ;
rdfs:subClassOf obo:DOID_4 .
obo:MPATH_3 a rdfs:Class ;
rdfs:label "apoptosis" ;
rdfs:comment "Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies." ;
rdfs:subClassOf obo:OBI_1110122 .
a rdfs:Class ;
rdfs:label "sleep time" ;
rdfs:comment "measurement of the time at which sleep begins" ;
rdfs:subClassOf .
obo:NCIT_C25736 a rdfs:Class ;
rdfs:label "Fibrinogen" ;
rdfs:comment "A fibrillar protein present in blood plasma; it converts to fibrin during the process of blood clot formation." ;
rdfs:subClassOf obo:GO_0032991 .
obo:UBERON_0002113 a rdfs:Class ;
rdfs:label "kidney" ;
rdfs:comment "A paired organ of the urinary tract which has the production of urine as its primary function." ;
rdfs:subClassOf obo:UBERON_0000062 .
obo:BMONT_0000049 a rdfs:Class ;
rdfs:label "systolic function" ;
rdfs:comment "Systolic function refers to the heart's ability to throw out a specific amount of blood in a certain amount of time." ;
rdfs:subClassOf obo:GO_0008150 .
obo:NCIT_C128056 a rdfs:Class ;
rdfs:label "Perfusion-Weighted Magnetic Resonance Imaging" ;
rdfs:comment "A magnetic resonance imaging modality used to quantify the blood supply to an organ or tissue using signal measurement as detected from a parenterally administered contrast agent." ;
rdfs:subClassOf obo:NCIT_C16809 .
obo:DOID_8893 a rdfs:Class ;
rdfs:label "psoriasis" ;
rdfs:comment "A skin disease that is characterized by patches of thick red skin and silvery scales." ;
rdfs:subClassOf obo:DOID_37 .
obo:PATO_0002096 a rdfs:Class ;
rdfs:label "neoplastic, non-malignant" ;
rdfs:comment "A disposition inhering in a tumour by virtue of the bearer's disposition not to progress, invade surrounding tissues or metastasize." ;
rdfs:subClassOf obo:BFO_0000019 .
obo:CHEBI_16670 a rdfs:Class ;
rdfs:label "peptide" ;
rdfs:comment "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:BMONT_0000100 a rdfs:Class ;
rdfs:label "imaging biomarker text mining bin" ;
rdfs:comment "A placeholder for imaging biomarkers, organized based on the reasoning application 'isImagingBiomarkerFor some disease', to facilitate text mining and information retrieval for specific diseases." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "GrimAge clock"@en ;
rdfs:comment "An epigenetic clock called DNA methylation GrimAge (DNAmGrimAge) was specifically designed to connect the relationship between “grim” events such as death and biological age and its derivation was based on smoking pack-years and multiple inflammatory proteins associated with mortality." ;
rdfs:subClassOf .
obo:CHEBI_47867 a rdfs:Class ;
rdfs:label "indicator" ;
rdfs:comment "Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc." ;
rdfs:subClassOf obo:BFO_0000023 .
obo:OMIT_0008544 a rdfs:Class ;
rdfs:label "Intracranial Pressure" ;
rdfs:comment "Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity." ;
rdfs:subClassOf .
obo:DOID_1579 a rdfs:Class ;
rdfs:label "respiratory system disease" ;
rdfs:comment "A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm." ;
rdfs:subClassOf obo:DOID_4 .
obo:PR_000000001 a rdfs:Class ;
rdfs:label "protein" ;
rdfs:comment "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:BMONT_0000084 a rdfs:Class ;
rdfs:label "arterial compliance" ;
rdfs:comment "Arterial compliance is a change in dimension in response to a given change in stress." ;
rdfs:subClassOf .
obo:BMONT_0000070 a rdfs:Class ;
rdfs:label "diagnostic biomarker text mining bin" ;
rdfs:comment "A placeholder for diagnostic biomarkers, organized based on the reasoning application 'isDiagnosticBiomarkerFor some disease', to facilitate text mining and information retrieval for specific diseases." ;
rdfs:subClassOf .
obo:OBCS_0000054 a rdfs:Class ;
rdfs:label "odds ratio" ;
rdfs:comment "A data item that refers to the odds that an individual with a specific condition has been exposed to a risk factor divided by the odds that a control has been exposed. The odds ratio is used in case-control studies. The odds ratio provides a reasonable estimate of the relative risk for uncommon conditions." ;
rdfs:subClassOf obo:IAO_0000027 .
obo:DOID_850 a rdfs:Class ;
rdfs:label "lung disease" ;
rdfs:comment "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide." ;
rdfs:subClassOf obo:DOID_4 .
obo:OPMI_0000464 a rdfs:Class ;
rdfs:label "cancer marker"@en ;
rdfs:subClassOf obo:OPMI_0000450 .
obo:OBI_0000185 a rdfs:Class ;
rdfs:label "imaging assay" ;
rdfs:comment "An assay that produces a picture of an entity." ;
rdfs:subClassOf obo:OBI_0000070 .
a rdfs:Class ;
rdfs:label "cytokine" ;
rdfs:subClassOf obo:PR_000000001 .
obo:DOID_684 a rdfs:Class ;
rdfs:label "hepatocellular carcinoma" ;
rdfs:comment "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." ;
rdfs:subClassOf obo:DOID_162 .
obo:DOID_0050589 a rdfs:Class ;
rdfs:label "inflammatory bowel disease" ;
rdfs:comment "An intestinal disease characterized by inflammation located in all parts of digestive tract." ;
rdfs:subClassOf obo:DOID_4 .
obo:OBI_0200103 a rdfs:Class ;
rdfs:label "multiple linear regression analysis"@en ;
rdfs:comment """multiple linear regression is a regression method that models the relationship between a dependent variable Y, independent variables Xi, i = 1, ..., p, and a random term epsilon. The model can be written as
Y = \\beta_0 + \\beta_1 X_1 + \\beta_2 X_2 + \\cdots +\\beta_p X_p + \\varepsilon
where \\beta_0 = 0 is the intercept (\"constant\" term), the \\beta_i s are the respective parameters of independent variables, and p is the number of parameters to be estimated in the linear regression."""@en ;
rdfs:subClassOf obo:GSSO_012786 .
obo:NCIT_C16809 a rdfs:Class ;
rdfs:label "Magnetic Resonance Imaging" ;
rdfs:comment "Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders." ;
rdfs:subClassOf obo:NCIT_C17369 .
obo:OPMI_0000458 a rdfs:Class ;
rdfs:label "DNA biomarker"@en ;
rdfs:comment "A molecular biomarker at the DNA gene level" ;
rdfs:subClassOf obo:OPMI_0000452 .
obo:HP_0012444 a rdfs:Class ;
rdfs:label "Brain atrophy" ;
rdfs:comment "Partial or complete wasting (loss) of brain tissue that was once present." ;
rdfs:subClassOf obo:HP_0000118 .
obo:SCDO_1000433 a rdfs:Class ;
rdfs:label "Intestinal Injury" ;
rdfs:comment "Damage inflicted on the intestine." ;
rdfs:subClassOf obo:DOID_4 .
obo:PATO_0000011 a rdfs:Class ;
rdfs:label "age" ;
rdfs:comment "A time quality inhering in a bearer by virtue of how long the bearer has existed." ;
rdfs:subClassOf obo:PATO_0001241 .
obo:DOID_6000 a rdfs:Class ;
rdfs:label "congestive heart failure" ;
rdfs:comment "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." ;
rdfs:subClassOf obo:DOID_114 .
a rdfs:Class ;
rdfs:label "knee extension strength"@en ;
rdfs:comment "Knee extension strength refers to the amount of force that the muscles on the front of the thigh—primarily the quadriceps—can generate to straighten (extend) the knee joint." ;
rdfs:subClassOf .
obo:GO_0009987 a rdfs:Class ;
rdfs:label "cellular process" ;
rdfs:comment "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." ;
rdfs:subClassOf obo:GO_0008150 .
obo:CHEBI_35341 a rdfs:Class ;
rdfs:label "steroid" ;
rdfs:comment "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." ;
rdfs:subClassOf obo:CHEBI_18059 .
obo:NCIT_C88164 a rdfs:Class ;
rdfs:label "Cardiorespiratory Fitness" ;
rdfs:comment "The ability of the heart and lungs to deliver blood and oxygen to the tissues during aerobic activity. It is a general measure of the relative conditioning of the heart and respiratory system." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BFO_0000035 a rdfs:Class ;
rdfs:label "process boundary"@en ;
rdfs:comment "p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])"@en ;
rdfs:subClassOf obo:BFO_0000003 .
obo:OPMI_0000453 a rdfs:Class ;
rdfs:label "cellular biomarker"@en ;
rdfs:comment "Cellular biomarkers are marked cells that can be isolated, sorted, quantified and characterized by their morphology and physiology, and used in both clinical and laboratory settings for different biomarker applications. An example of a cellular biomarker sorting technique is Fluorescent-activated cell sorting." ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:NCIT_C82669 a rdfs:Class ;
rdfs:label "Center for Drug Evaluation and Research" ;
rdfs:comment "The center within the Food and Drug Administration that assures the safety and effectiveness of drugs that are made available to improve the health of people in the United States. It regulates over-the-counter and prescription drugs, including biological therapeutics and generic drugs." ;
rdfs:subClassOf obo:NCIT_C17237 .
obo:CL_0000084 a rdfs:Class ;
rdfs:label "T cell" ;
rdfs:comment "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." ;
rdfs:subClassOf obo:CL_0000542 .
a rdfs:Class ;
rdfs:label "sleep duration" ;
rdfs:comment "duration of sleep, measured either via a self-reporting questionnaire, interview or through obversation in a sleep lab" ;
rdfs:subClassOf .
obo:NCIT_C82670 a rdfs:Class ;
rdfs:label "Center for Devices and Radiological Health" ;
rdfs:comment "The Center within the Food and Drug Administration that is responsible for regulating firms who manufacture, repackage, relabel, and/or import medical devices sold in the United States. In addition, it regulates radiation-emitting electronic products (medical and non-medical) such as lasers, x-ray systems, ultrasound equipment, microwave ovens and color televisions." ;
rdfs:subClassOf obo:NCIT_C17237 .
a rdfs:Class ;
rdfs:label "cortical thinning"@en ;
rdfs:comment "Cortical thinning is the gradual reduction in the thickness of the brain’s cerebral cortex—the outer layer of neural tissue involved in functions such as perception, memory, and decision-making. It is commonly measured using neuroimaging techniques like MRI and is associated with normal aging, neurodegenerative diseases (e.g., Alzheimer’s), and certain psychiatric conditions." ;
rdfs:subClassOf obo:OBI_1110122 .
obo:BMONT_0000119 a rdfs:Class ;
rdfs:label "fractional anisotropy" ;
rdfs:comment "Fractional Anisotropy (FA) is a metric derived from diffusion tensor imaging (DTI), a magnetic resonance imaging (MRI) technique used to study the microstructural organization of tissues, particularly white matter in the brain. FA quantifies the degree of anisotropy of water diffusion within tissue. In white matter, water molecules tend to diffuse more easily along the direction of the fiber tracts (axonal bundles) than perpendicular to them. FA values range from 0 to 1, where higher values indicate greater directionality or organization of the tissue microstructure, typically reflecting intact white matter tracts." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:NCIT_C113609 a rdfs:Class ;
rdfs:label "Chronic Liver Disease" ;
rdfs:comment "Hepatic necrosis, inflammation, or scarring due to any cause that persists for more than 6 months. Manifestations may include signs and symptoms of cholestasis, portal hypertension, and/or abnormal liver function tests." ;
rdfs:subClassOf obo:DOID_409 .
obo:BFO_0000019 a rdfs:Class ;
rdfs:label "quality"@en ;
rdfs:subClassOf obo:BFO_0000020 .
obo:MONDO_0001343 a rdfs:Class ;
rdfs:label "impaired renal function disease" ;
rdfs:comment "Any disease in which the causes of the disease is a perturbation of the kidney leading to its dysfunction." ;
rdfs:subClassOf obo:DOID_557 .
a rdfs:Class ;
rdfs:label "survival time" ;
rdfs:comment "Time of survival is an information entity which is about the length of time a material entity has survived after some adverse event, such as infection from a disease." ;
rdfs:subClassOf .
obo:MONDO_0004975 a rdfs:Class ;
rdfs:label "Alzheimer disease" ;
rdfs:comment "A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language." ;
rdfs:subClassOf obo:MONDO_0005559 .
obo:PR_000003777 a rdfs:Class ;
rdfs:label "adiponectin" ;
rdfs:comment "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:CHEBI_35143 a rdfs:Class ;
rdfs:label "hemoglobin" ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:BMONT_0000033 a rdfs:Class ;
rdfs:label "21st Century Cures Act" ;
rdfs:comment "The 21st Century Cures Act (Cures Act), signed into law on December 13, 2016, is designed to help accelerate medical product development and bring new innovations and advances to patients who need them faster and more efficiently." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:ICO_0000233 .
a rdfs:Class ;
rdfs:label "glomerular filtration rate" ;
rdfs:comment "measurement of the flow rate of filtered fluid through the kidney, calculated either by comparative measurements of substances in the blood and urine, or estimated from a blood test" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "mortality" ;
rdfs:comment "Quantification of the number of deaths in a population." ;
rdfs:subClassOf .
obo:CMO_0000765 a rdfs:Class ;
rdfs:label "creatinine clearance" ;
rdfs:comment "The clearance rate of creatinine, that is, the volume of plasma that is cleared of creatinine by the kidneys per unit time. Creatinine clearance is calculated using the level of creatinine in a sample of urine, usually one collected over a period of 24 hours, the corresponding plasma creatinine level, and the volume of urine excreted. It is used as an approximation of the glomerular filtration rate (GFR)." ;
rdfs:subClassOf obo:CMO_0000000 .
obo:OBI_0002650 a rdfs:Class ;
rdfs:label "biopsy" ;
rdfs:comment "A specimen collection that obtains a sample of tissue or cell from a living multicellular organism body for diagnostic purposes by means intended to be minimally invasive." ;
rdfs:subClassOf obo:OBI_0000011 .
obo:NCIT_C61256 a rdfs:Class ;
rdfs:label "Monitoring" ;
rdfs:comment "The act of observing something (and sometimes keeping a record of it)." ;
rdfs:subClassOf obo:BFO_0000015 .
obo:PR_000006933 a rdfs:Class ;
rdfs:label "epidermal growth factor receptor" ;
rdfs:comment "An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:BMONT_0000111 a rdfs:Class ;
rdfs:label "tumor metabolism" ;
rdfs:comment "Tumor metabolism refers to the biochemical processes occurring within cancer cells to meet their energy demands, support growth, and sustain proliferation. Cancer cells exhibit distinct metabolic characteristics compared to normal cells, which enable them to adapt to the unique microenvironment of tumors and support their uncontrolled growth." ;
rdfs:subClassOf obo:GO_0008150 .
a rdfs:Class ;
rdfs:label "functional microbiome measurement" ;
rdfs:comment "quantification of the functional variation in a microbiome" ;
rdfs:subClassOf .
obo:CHEBI_24621 a rdfs:Class ;
rdfs:label "hormone" ;
rdfs:comment "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." ;
rdfs:subClassOf obo:CHEBI_24432 .
obo:CMO_0003717 a rdfs:Class ;
rdfs:label "pulse wave velocity" ;
rdfs:comment "Pulse wave velocity (PWV) is a measurement of arterial stiffness that is an independent predictor of cardiovascular risk. It can be measured simply and noninvasively by measuring the carotid and femoral pulse pressures and the time delay between the two or by other methods relying on pulse-wave analysis." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "pulmonary arterial hypertension" ;
rdfs:comment "Pulmonary arterial hypertension (PAH) is a group of diseases characterized by mean pulmonary artery pressure >20 mmHg and elevated pulmonary arterial resistance leading to right heart failure. PAH is progressive and potentially fatal. PAH may be idiopathic and/ or familial, have overt features of venous/capillary involvement (pulmonary veno-occlusive disease, PVOD/pulmonary capillary hemangiomatosis, PCH), induced by drug or toxin (drug-or toxin-induced PAH), or associated with other diseases like congenital heart disease, connective tissue disease, HIV, schistosomiasis, portal hypertension (PAH associated with other disease)." ;
rdfs:subClassOf obo:DOID_10763 .
obo:CL_0000542 a rdfs:Class ;
rdfs:label "lymphocyte" ;
rdfs:comment "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." ;
rdfs:subClassOf obo:CL_0000738 .
obo:OGMS_0000143 a rdfs:Class ;
rdfs:label "transplantation" ;
rdfs:comment "A therapeutic procedure in which a body part is transferred into a organism" ;
rdfs:subClassOf obo:MAXO_0000002 .
obo:BMONT_0000029 a rdfs:Class ;
rdfs:label "chronic pain biomarker" ;
rdfs:comment "Biomarkers that represent acute and chronic pain, predisposition to develop chronic pain and , and pain chronification, recovery and treatment outcomes." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:OPMI_0000445 .
a rdfs:Class ;
rdfs:label "copy number variation" ;
rdfs:comment "A quantification of a genomic variation that increases or decreases the copy number of a given region." ;
rdfs:subClassOf .
obo:NCIT_C201303 a rdfs:Class ;
rdfs:label "Response Biomarker" ;
rdfs:comment "A biomarker used to show that a biological response, potentially beneficial or harmful, has occurred in an individual who has been exposed to a medical product or an environmental agent. (NIH-FDA BEST (Biomarkers, Endpoints, and other Tools) Resource)" ;
rdfs:subClassOf obo:OPMI_0000445 .
a rdfs:Class ;
rdfs:label "vascular endothelial growth factor" ;
rdfs:comment """Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. Serum concentration of VEGF is high in bronchial asthma and low in diabetes mellitus. VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.
When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as bevacizumab can inhibit VEGF and control or slow those diseases.
VEGF is a sub-family of growth factors, to be specific, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).""" ;
rdfs:subClassOf obo:PR_000000001 .
a rdfs:Class ;
rdfs:label "extrinsic epigenetic age acceleration"@en ;
rdfs:comment "Extrinsic Epigenetic Age Acceleration is a metric used to estimate biological aging by incorporating both DNA methylation patterns and changes in blood cell composition. This measure reflects the combined effects of intrinsic cellular aging (similar to IEAA) and the aging of the immune system, which involves shifts in certain immune cell types, such as T cells and B cells." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:OBI_0000066 a rdfs:Class ;
rdfs:label "investigation"@en ;
rdfs:comment "a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s)."@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:MONDO_0024644 a rdfs:Class ;
rdfs:label "myocardial ischemia" ;
rdfs:comment "A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction)." ;
rdfs:subClassOf obo:DOID_178 .
a rdfs:Class ;
rdfs:label "peak expiratory flow" ;
rdfs:comment "The maximum rate of gas flow, beginning at the point of peak inspiratory capacity, that can be sustained during forced exhalation for a defined period of time. This test is most often used in combination with other studies of lung function to diagnose and monitor obstructive and restrictive lung disease(s). [ NCI ]" ;
rdfs:subClassOf .
obo:BMONT_0000018 a rdfs:Class ;
rdfs:label "analitical validation" ;
rdfs:comment "Analytical validation aims to establish the performance characteristics of a biomarker including sensitivity, specificity, accuracy, precision, inter-laboratory reproducibility and other relevant performance characteristics following a pre-specified protocol." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:BMONT_0000017 .
obo:UBERON_0000174 a rdfs:Class ;
rdfs:label "excreta" ;
rdfs:comment "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." ;
rdfs:subClassOf obo:UBERON_0000463 .
obo:DOID_3312 a rdfs:Class ;
rdfs:label "bipolar disorder" ;
rdfs:comment "A mood disorder that involves alternating periods of mania and depression." ;
rdfs:subClassOf obo:DOID_4 .
obo:MONDO_0004335 a rdfs:Class ;
rdfs:label "digestive system disorder" ;
rdfs:comment "A disease or disorder that involves the digestive system." ;
rdfs:subClassOf obo:OGMS_0000045 .
obo:CHEBI_16113 a rdfs:Class ;
rdfs:label "cholesterol" ;
rdfs:comment "A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group." ;
rdfs:subClassOf obo:CHEBI_18059 .
obo:BMONT_0000098 a rdfs:Class ;
rdfs:label "digital biomarker text mining bin" ;
rdfs:comment "A placeholder for digital biomarkers, organized based on the reasoning application 'isDigitalBiomarkerFor some disease', to facilitate text mining and information retrieval for specific diseases." ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "airway wall thickness measurement" ;
rdfs:comment "Quantification of the thickness of the walls of different parts of the respiratory tract, calculated from cross-sectional CT images. This measure can be used as an indicator of airway obstruction severity in COPD." ;
rdfs:subClassOf .
obo:OPMI_0000454 a rdfs:Class ;
rdfs:label "imaging biomarker"@en ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:NCIT_C116753 a rdfs:Class ;
rdfs:label "Apparent Diffusion Coefficient" ;
rdfs:comment "A measurement of the magnitude of diffusion of water molecules within tissue." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:BFO_0000020 a rdfs:Class ;
rdfs:label "specifically dependent continuant"@en ;
rdfs:comment "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en ;
rdfs:subClassOf obo:BFO_0000002 .
obo:CHEBI_27680 a rdfs:Class ;
rdfs:label "galactomannan" ;
rdfs:comment "A heteroglycan consisting of a mannan backbone with galactose side groups." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:BMONT_0000087 a rdfs:Class ;
rdfs:label "step count" ;
rdfs:comment "Step count is a widely used metric for tracking physical activity, particularly walking. It measures the total number of steps an individual takes over a specified period, typically daily. Step count is a simple yet effective way to monitor activity levels and promote a healthy lifestyle." ;
rdfs:subClassOf obo:BMONT_0000086 .
obo:NCIT_C41389 a rdfs:Class ;
rdfs:label "Positive Predictive Value of Diagnostic Test" ;
rdfs:comment "The probability that an individual is affected with the condition when a positive test result is observed. Predictive values should only be calculated from cohort studies or studies that legitimately reflect the number of people in the population who have the condition of interest at that time since predictive values are inherently dependent upon the prevalence. PPVDT can be determined by calculating: number of true positive results divided by the sum of true positive results plus number of false positive results." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:IAO_0000027 .
a rdfs:Class ;
rdfs:label "postmenopausal" ;
rdfs:subClassOf obo:BFO_0000015 .
obo:BMONT_0000115 a rdfs:Class ;
rdfs:label "functional connectivity density" ;
rdfs:comment "Functional connectivity density (FCD) is a measure used in neuroimaging, particularly in functional magnetic resonance imaging (fMRI) studies, to quantify the strength and distribution of functional connections between different brain regions." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:DOID_10283 a rdfs:Class ;
rdfs:label "prostate cancer" ;
rdfs:comment "A male reproductive organ cancer that is located_in the prostate." ;
rdfs:subClassOf obo:DOID_162 .
obo:BMONT_0000078 a rdfs:Class ;
rdfs:label "digital device" ;
rdfs:comment "A digital device refers to any electronic tool, gadget, or hardware that utilizes digital technology to perform specific functions or tasks. These devices are prevalent in various aspects of modern life, including communication, entertainment, productivity, health, and education. Digital devices encompass a wide range of technologies, from computers and smartphones to wearables and smart home appliances." ;
rdfs:subClassOf obo:OBI_0000968 .
obo:OPMI_0000447 a rdfs:Class ;
rdfs:label "cytokine biomarker"@en ;
rdfs:subClassOf obo:OPMI_0000446 .
obo:GSSO_012786 a rdfs:Class ;
rdfs:label "statistical analysis"@en ;
rdfs:comment "Analyses regarding statistical data."@en ;
rdfs:subClassOf obo:OBI_0000011 .
obo:OMIT_0026291 a rdfs:Class ;
rdfs:label "Biochemical Processes" ;
rdfs:comment "Adjusting the quantity and quality of food intake to improve health status of an individual. This term does not include the methods of food intake (NUTRITIONAL SUPPORT)." ;
rdfs:subClassOf obo:BFO_0000015 .
a rdfs:Class ;
rdfs:label "MetaboAge score"@en ;
rdfs:comment "The MetaboAge score is a biological age predictor based on metabolomic biomarkers. It is calculated using a model that analyzes 63 metabolites in the blood, allowing researchers to estimate an individual’s biological age as opposed to their chronological age. A key feature of MetaboAge is the difference between the predicted metabolomic age and the actual chronological age (referred to as ΔMetaboAge). A positive ΔMetaboAge may suggest accelerated biological aging and a higher risk of mortality. This score has been validated in various studies and is often used to study aging and its relation to mortality and other health outcomes." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:GSSO_008334 a rdfs:Class ;
rdfs:label "donor"@en , "donor"@da ;
rdfs:comment "A person who makes a donation."@en ;
rdfs:subClassOf obo:BFO_0000004 .
a rdfs:Class ;
rdfs:label "nephrotic syndrome" ;
rdfs:comment "A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction." ;
rdfs:subClassOf obo:DOID_557 .
obo:HP_0012823 a rdfs:Class ;
rdfs:label "Clinical modifier" ;
rdfs:comment "This subontology is designed to provide terms to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects." ;
rdfs:subClassOf obo:BFO_0000019 .
obo:MI_0252 a rdfs:Class ;
rdfs:label "biological feature" ;
rdfs:comment "Property of a subsequence that may be involved with or interfere with the binding of a molecule and are supported by experimental evidences." ;
rdfs:subClassOf obo:BFO_0000019 .
obo:GO_0032991 a rdfs:Class ;
rdfs:label "protein-containing complex" ;
rdfs:comment "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." ;
rdfs:subClassOf obo:BFO_0000040 .
obo:NCIT_C28234 a rdfs:Class ;
rdfs:label "Progression-free Survival" ;
rdfs:subClassOf .
obo:OMIT_0003470 a rdfs:Class ;
rdfs:label "Calcium Metabolism Disorders" ;
rdfs:comment "Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization." ;
rdfs:subClassOf obo:OGMS_0000045 .
obo:DOID_10538 a rdfs:Class ;
rdfs:label "gastric fundus cancer" ;
rdfs:comment "A stomach cancer that is located_in the gastric fundus." ;
rdfs:subClassOf obo:DOID_162 .
a rdfs:Class ;
rdfs:label "BloodAge"@en ;
rdfs:comment "BloodAge refers to a biological age estimation method that uses a blood-based proteomic signature to assess how old a person is biologically, as opposed to their chronological age. By analyzing the levels of specific proteins in the blood, this method predicts a person's biological aging and potential risk for age-related diseases." ;
rdfs:subClassOf .
obo:GO_0006955 a rdfs:Class ;
rdfs:label "immune response" ;
rdfs:comment "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." ;
rdfs:subClassOf obo:GO_0008150 .
obo:CHEBI_17929 a rdfs:Class ;
rdfs:label "N(omega),N(omega)-dimethyl-L-arginine" ;
rdfs:comment "A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:PR_000007939 a rdfs:Class ;
rdfs:label "glial fibrillary acidic protein" ;
rdfs:comment "A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
obo:UBERON_0000463 a rdfs:Class ;
rdfs:label "organism substance" ;
rdfs:comment "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." ;
rdfs:subClassOf obo:UBERON_0000061 .
obo:PR_000004716 a rdfs:Class ;
rdfs:label "brain-derived neurotrophic factor" ;
rdfs:comment "A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:OGG_0000000002 .
a rdfs:Class ;
rdfs:label "chronotype measurement" ;
rdfs:comment "quantification of some aspect of chronotype such as ease of getting up in the morning" ;
rdfs:subClassOf .
obo:OPMI_0000461 a rdfs:Class ;
rdfs:label "imaging disease biomarker"@en ;
rdfs:comment "A biomarker that is indicative of a disease and achieved through imaging." ;
rdfs:subClassOf obo:OPMI_0000450 , obo:OPMI_0000454 .
a rdfs:Class ;
rdfs:label "DNA methylation risk score"@en ;
rdfs:comment "DNA methylation-based risk score is a relatively recent metric used in research to assess biological age and associated health risks based on DNA methylation patterns. It evaluates the methylation levels at specific sites in the genome that are linked to various health outcomes, effectively providing a score that reflects the biological age of an individual as opposed to their chronological age." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:IAO_0000109 a rdfs:Class ;
rdfs:label "measurement datum"@en ;
rdfs:comment "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device."@en ;
rdfs:subClassOf obo:IAO_0000027 .
obo:NCIT_C17237 a rdfs:Class ;
rdfs:label "Food and Drug Administration" ;
rdfs:comment "One of the agencies of the U.S. Department of Health and Human Services. It assures the safety of foods and cosmetics, and the safety and efficacy of pharmaceuticals, biological products, radiation emitting products, medical devices, and also, animal feed and drugs." ;
rdfs:subClassOf obo:BMONT_0000027 .
obo:DOID_2351 a rdfs:Class ;
rdfs:label "iron metabolism disease"@en ;
rdfs:subClassOf obo:DOID_0014667 .
obo:OPMI_0000450 a rdfs:Class ;
rdfs:label "disease biomarker"@en ;
rdfs:comment "A biomarker that is indicative of a disease" ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:BMONT_0000038 a rdfs:Class ;
rdfs:label "urine total potein" ;
rdfs:comment "Urinary total protein (UTP) includes all proteins in urine samples. The presence of some quantities of proteins (<150 mg/day) is considered normal." ;
rdfs:subClassOf obo:PR_000000001 .
obo:CHEBI_5931 a rdfs:Class ;
rdfs:label "insulin (human)" ;
rdfs:comment "An insulin that is produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two peptide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes." ;
rdfs:subClassOf obo:CHEBI_23367 .
obo:SO_0000276 a rdfs:Class ;
rdfs:label "miRNA" ;
rdfs:comment "Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes. Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors." ;
rdfs:subClassOf obo:OGG_0000000002 .
obo:DOID_557 a rdfs:Class ;
rdfs:label "kidney disease" ;
rdfs:comment "A urinary system disease that is located_in the kidney." ;
rdfs:subClassOf obo:DOID_4 .
obo:BMONT_0000007 a rdfs:Class ;
rdfs:label "companion endpoint" ;
rdfs:comment "A biomarker that is essential to the efficacy and safety of a corresponding therapeutic product." ;
rdfs:subClassOf obo:OPMI_0000445 .
obo:MONDO_0005559 a rdfs:Class ;
rdfs:label "neurodegenerative disease" ;
rdfs:comment "A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function." ;
rdfs:subClassOf obo:DOID_4 .
a rdfs:Class ;
rdfs:label "hannum clock"@en ;
rdfs:comment "The Hannum Clock is one of the early and widely recognized epigenetic clocks designed to estimate biological age by analyzing DNA methylation patterns. It was developed by Dr. Gregory Hannum and his colleagues in 2013 and represents a key advancement in the field of aging research." ;
rdfs:subClassOf .
obo:MPATH_34 a rdfs:Class ;
rdfs:label "amyloid deposition" ;
rdfs:comment "Extracellular deposition of amyloid protein." ;
rdfs:subClassOf obo:MPATH_0 .
obo:DOID_2841 a rdfs:Class ;
rdfs:label "asthma" ;
rdfs:comment "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing." ;
rdfs:subClassOf obo:DOID_850 .
obo:GO_0001525 a rdfs:Class ;
rdfs:label "angiogenesis" ;
rdfs:comment "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." ;
rdfs:subClassOf obo:GO_0008150 .
obo:GO_0005577 a rdfs:Class ;
rdfs:label "fibrinogen complex" ;
rdfs:comment "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." ;
rdfs:subClassOf obo:UBERON_0001062 .
a rdfs:Class ;
rdfs:label "seasonal gut microbiome measurement" ;
rdfs:comment "quantification of some aspect of the seasonal variation in the micrbiome of the gut" ;
rdfs:subClassOf .
obo:BMONT_0000080 a rdfs:Class ;
rdfs:label "smartwatch" ;
rdfs:comment "A smartwatch is a wearable device that combines the functionality of a traditional wristwatch with features typically associated with smartphones and other electronic devices. Smartwatches offer a wide range of capabilities, including timekeeping, notifications, health and fitness tracking, communication, and app integration, all accessible from the user's wrist." ;
rdfs:subClassOf obo:BMONT_0000079 .
obo:OGMS_0000063 a rdfs:Class ;
rdfs:label "disease course" ;
rdfs:comment "The totality of all processes through which a given disease instance is realized."@en ;
rdfs:subClassOf obo:BFO_0000015 .
obo:DOID_4 a rdfs:Class ;
rdfs:label "disease" ;
rdfs:comment "A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism." ;
rdfs:subClassOf obo:BFO_0000016 .
a rdfs:Class ;
rdfs:label "ejection fraction measurement" ;
rdfs:comment "quantification of the volumetric fraction of blood pumped out of the left and right ventricle with each heartbeat or cardiac cycle" ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "bone density" ;
rdfs:comment "The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS." ;
rdfs:subClassOf obo:BMONT_0000081 .
obo:DOID_1575 a rdfs:Class ;
rdfs:label "rheumatic disease" ;
rdfs:comment "A musculoskeletal system disease that involves inflammation or pain in the muscles, joints, or fibrous tissue." ;
rdfs:subClassOf obo:DOID_4 .
obo:PATO_0001486 a rdfs:Class ;
rdfs:label "chronological age" ;
rdfs:comment "An age quality that exists by virtue of the time (years and months) that the bearer has existed." ;
rdfs:subClassOf obo:PATO_0000011 .
obo:OBI_0000075 a rdfs:Class ;
rdfs:label "diagnosis textual entity"@en ;
rdfs:comment "diagnosis is an assessment of a disease or injury, its likely prognosis and treatment."@en ;
rdfs:subClassOf obo:IAO_0000300 .
obo:UBERON_0034919 a rdfs:Class ;
rdfs:label "juvenile stage" ;
rdfs:comment "The stage of being no more dependent of the nest and/or from caregivers for subsistence while having not reach sexual maturity." ;
rdfs:subClassOf obo:GO_0008150 .
a rdfs:Class ;
rdfs:label "interleukin" ;
rdfs:comment "An interleukin is a multifunctional cytokine produced by leukocytes for regulating immune responses." ;
rdfs:subClassOf .
obo:BMONT_0000005 a rdfs:Class ;
rdfs:label "copy number variant biomarker" ;
rdfs:comment "A biomarker of genomic variation in which blocks of DNA are missing or for which multiple copies exist." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:OPMI_0000445 .
a rdfs:Class ;
rdfs:label "chromosomal aberration frequency" ;
rdfs:comment "Frequency of chromosomal aberrations in human peripheral blood." ;
rdfs:subClassOf .
obo:NCIT_C686 a rdfs:Class ;
rdfs:label "Neuropeptide" ;
rdfs:comment "Peptides with direct synaptic effects or indirect modulatory effects on the nervous system. A neuropeptide is a molecule released by neurons as an intercellular neurotransmitter. Alternatively, neuropeptides can be released by non-neuronal cells as hormones. They are endogenous peptides such as endorphins that influence neural activity or functioning." ;
rdfs:subClassOf obo:PR_000000001 .
obo:OBI_0100017 a rdfs:Class ;
rdfs:label "blood serum specimen"@en ;
rdfs:comment "A material entity which derives from blood and corresponds to blood plasma without fibrinogen or the other clotting factors."@en ;
rdfs:subClassOf obo:OBI_0100051 .
obo:NCIT_C16866 a rdfs:Class ;
rdfs:label "Model" ;
rdfs:comment "A representation of something, often idealized or modified to make it conceptually easier to understand." ;
rdfs:subClassOf obo:IAO_0000030 .
obo:DOID_5082 a rdfs:Class ;
rdfs:label "liver cirrhosis" ;
rdfs:subClassOf obo:DOID_409 .
a rdfs:Class ;
rdfs:label "mitotic clock"@en ;
rdfs:subClassOf .
a rdfs:Class ;
rdfs:label "pulmonary function measurement" ;
rdfs:comment "Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc." ;
rdfs:subClassOf .
obo:UBERON_0002107 a rdfs:Class ;
rdfs:label "liver" ;
rdfs:comment "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." ;
rdfs:subClassOf obo:UBERON_0000062 .
obo:BMONT_0000016 a rdfs:Class ;
rdfs:label "context of use" ;
rdfs:comment "The context of use is a concise description of a biomarker's specified use in drug developement." ;
rdfs:seeAlso ;
rdfs:subClassOf obo:IAO_0000030 .
obo:OGMS_0000023 a rdfs:Class ;
rdfs:label "phenotype" ;
rdfs:comment "A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species."@en ;
rdfs:subClassOf obo:BFO_0000019 .
a rdfs:Class ;
rdfs:label "fibrosis" ;
rdfs:comment "the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This can be a reactive, benign, or pathological state." ;
rdfs:subClassOf obo:MONDO_0005070 .
a rdfs:Class ;
rdfs:label "insomnia measurement" ;
rdfs:comment "quantification of insomnia such as how often it occurs and its severity" ;
rdfs:subClassOf .
obo:BMONT_0000027 a rdfs:Class ;
rdfs:label "biomarker regulatory entity" ;
rdfs:comment "A biomarker regulatory entity refers to a regulatory organization responsible for qualification and acceptance of biomarkers for futrher use in pharmaceutical research and development." ;
rdfs:subClassOf obo:BFO_0000004 .
a rdfs:Class ;
rdfs:label "ELOVL2 hypermethilation"@en ;
rdfs:comment "ELOVL2 hypermethylation refers to an increase in DNA methylation at the ELOVL2 gene, which has been consistently associated with aging. The ELOVL2 gene encodes an enzyme involved in the elongation of very long-chain fatty acids. It has emerged as one of the most reliable epigenetic biomarkers of aging." ;
rdfs:subClassOf obo:MI_0252 .
a rdfs:Class ;
rdfs:label "white matter hyperintensity measurement" ;
rdfs:comment "quantification of white matter hyperintensity, usually measured by MRI" ;
rdfs:subClassOf .
obo:PR_000002307 a rdfs:Class ;
rdfs:label "apoptosis regulator Bcl-2" ;
rdfs:comment "A Bcl-2-like apoptosis inhibitor that is a translation product of the human BCL2 gene or a 1:1 ortholog thereof." ;
rdfs:subClassOf obo:PR_000000001 .
a rdfs:Class ;
rdfs:label "calcium metabolic disease" ;
rdfs:comment "Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization." ;
rdfs:subClassOf obo:DOID_0014667 .
obo:BMONT_0000044 a rdfs:Class ;
rdfs:label "regulatory guideline" ;
rdfs:comment "Regulatory guidelines are documents issued by regulatory authorities or standardization organizations to provide recommendations, interpretations, instructions, or best practices for complying with regulatory requirements, industry standards, or established norms within a specific jurisdiction or field of activity. These guidelines offer guidance to regulated entities, stakeholders, and practitioners on how to interpret, implement, and adhere to applicable regulations, standards, or policies effectively." ;
rdfs:seeAlso