PREFIX include: <https://w3id.org/include/>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>

include:Condition a rdfs:Class ;
  rdfs:label "Condition" ;
  rdfs:comment "Co-occurring conditions and other observations for the participant" .

include:condition_status a rdf:Property ;
  rdfs:label "Condition Status" ;
  rdfs:comment "Whether the Condition is ongoing, has been resolved, or this is a general history of the condition without known dates" ;
  rdfs:range include:EnumConditionStatus .

include:event_type a rdf:Property ;
  rdfs:label "Event Type" ;
  rdfs:comment "Type of event for which Event ID is given (Visit, Survey completion, Sample collection, etc.)" ;
  rdfs:range xsd:string .

include:measure_value a rdf:Property ;
  rdfs:label "Measure Value" ;
  rdfs:comment "Numeric value of Measure" ;
  rdfs:range xsd:float .

include:maxo_label a rdf:Property ;
  rdfs:label "MAXO Label" ;
  rdfs:comment "Label for Condition in the Medical Action Ontology (MAXO)" ;
  rdfs:range xsd:string .

include:participant_external_id a rdf:Property ;
  rdfs:label "Participant External ID" ;
  rdfs:comment "Unique, de-identified identifier for the participant, assigned by data contributor. External IDs must be two steps removed from personal information in the study records." ;
  rdfs:range xsd:string .

include:measure_unit a rdf:Property ;
  rdfs:label "Measure Unit" ;
  rdfs:comment "Unit that is associated with Measure Value (e.g. kg, cm, %, x10^9/L, etc.)" ;
  rdfs:range xsd:string .

include:hpo_label a rdf:Property ;
  rdfs:label "HPO Label" ;
  rdfs:comment "Label for Condition in the Human Phenotype Ontology (HPO)" ;
  rdfs:range xsd:string .

include:maxo_code a rdf:Property ;
  rdfs:label "MAXO Code" ;
  rdfs:comment "Code for condition in the Medical Action Ontology (MAXO)" ;
  rdfs:range xsd:string .

include:condition_data_source a rdf:Property ;
  rdfs:label "Condition Data Source" ;
  rdfs:comment "Whether Condition information was obtained by the investigator or reported by participant/family member" ;
  rdfs:range include:EnumConditionDataSource .

include:condition_measure_source_text a rdf:Property ;
  rdfs:label "Condition or Measure Source Text" ;
  rdfs:comment "Co-occurring Condition (phenotype or diagnosis) or Measure (observation with numeric value), as described by data contributor. The Down Syndrome Genetic Diagnosis will be rolled into this field." ;
  rdfs:range xsd:string .

include:other_label a rdf:Property ;
  rdfs:label "Other Label" ;
  rdfs:comment "Label for Condition in another ontology (if no match in HPO, MONDO, or MAXO)" ;
  rdfs:range xsd:string .

include:hpo_code a rdf:Property ;
  rdfs:label "HPO Code" ;
  rdfs:comment "Code for Condition in the Human Phenotype Ontology (HPO)" ;
  rdfs:range xsd:string .

include:age_at_condition_measure_observation a rdf:Property ;
  rdfs:label "Age At Condition or Measure Observation" ;
  rdfs:comment "Age in days at which Condition or Measure was observed, recorded, or diagnosed" ;
  rdfs:range xsd:integer .

include:event_id a rdf:Property ;
  rdfs:label "Event ID" ;
  rdfs:comment "Identifier for event (Visit, Survey completion, Sample collection, etc.) to which the Condition data are linked, if applicable. There may be multiple events linked to a Participant." ;
  rdfs:range xsd:string .

include:mondo_label a rdf:Property ;
  rdfs:label "MONDO Label" ;
  rdfs:comment "Label for Condition in the Mondo Disease Ontology (MONDO)" ;
  rdfs:range xsd:string .

include:other_code a rdf:Property ;
  rdfs:label "Other Code" ;
  rdfs:comment "Code for Condition in another ontology (if no match in HPO, MONDO, or MAXO)" ;
  rdfs:range xsd:string .

include:study_code a rdf:Property ;
  rdfs:label "Study Code" ;
  rdfs:comment "Unique identifier for the study (generally a short acronym)" ;
  rdfs:range include:Study , include:EnumStudyCode .

include:mondo_code a rdf:Property ;
  rdfs:label "MONDO Code" ;
  rdfs:comment "Code for Condition in the Mondo Disease Ontology (Mondo)" ;
  rdfs:range xsd:string .

include:condition_interpretation a rdf:Property ;
  rdfs:label "Condition Interpretation" ;
  rdfs:comment "Whether Condition was observed or not" ;
  rdfs:range include:EnumConditionInterpretation .

include:participant_global_id a rdf:Property ;
  rdfs:label "Participant Global ID" ;
  rdfs:comment "Unique INCLUDE global identifier for the participant, assigned by DCC" ;
  rdfs:range include:Participant , xsd:string .

include:DataFile a rdfs:Class ;
  rdfs:label "Data File" ;
  rdfs:comment "Metadata about Data Files" .

include:file_s_3_location a rdf:Property ;
  rdfs:label "File S3 Location" ;
  rdfs:comment "S3 bucket location of file; also serves as dewrangle descriptor" ;
  rdfs:range xsd:string .

include:file_upload_location a rdf:Property ;
  rdfs:label "File Upload Location" ;
  rdfs:comment "Where source file was uploaded, if not directly to an S3 bucket (e.g. Synapse)" ;
  rdfs:range xsd:string .

include:file_size a rdf:Property ;
  rdfs:label "File Size" ;
  rdfs:comment "Size of file, if known (mainly important if large)" ;
  rdfs:range xsd:integer .

include:file_size_unit a rdf:Property ;
  rdfs:label "File Size Unit" ;
  rdfs:comment "Unit of file size" ;
  rdfs:range xsd:string .

include:data_category a rdf:Property ;
  rdfs:label "Data Category" ;
  rdfs:comment "General category of data in file (e.g. Clinical, Genomics, Proteomics, Metabolomics, Immune profiling, Transcriptomics)" , "Categories of data expected to be collected in this study" , "General category of data in Dataset; pipe-separated if multiple" ;
  rdfs:range include:EnumDataCategory .

include:data_access a rdf:Property ;
  rdfs:label "Data Access" ;
  rdfs:comment "Type of access control on this file, determined by DCC" ;
  rdfs:range include:EnumDataAccess .

include:data_type a rdf:Property ;
  rdfs:label "Data Type" ;
  rdfs:comment "Specific type of data contained in file (e.g. Preprocessed metabolite relative abundance, Absolute protein concentration, Aligned reads, Simple nucleotide variations, GVCF, Gene expression quantifications, Gene fusions, Somatic copy number variations, Somatic structural variations)" , "Specific type of data contained in Dataset; pipe-separated if multiple (e.g. Preprocessed metabolite relative abundance, Absolute protein concentration, Aligned reads, Simple nucleotide variations, GVCF, Gene expression quantifications, Gene fusions, Somatic copy number variations, Somatic structural variations)" ;
  rdfs:range xsd:string .

include:file_hash a rdf:Property ;
  rdfs:label "File Hash" ;
  rdfs:comment "md5 hash of this file for validation (if known)" ;
  rdfs:range xsd:string .

include:file_format a rdf:Property ;
  rdfs:label "File Format" ;
  rdfs:comment "Format of file (e.g. tsv, cram, gvcf, vcf, maf, txt, pdf, html, png)" ;
  rdfs:range xsd:string .

include:sample_global_id a rdf:Property ;
  rdfs:label "Sample Global ID" ;
  rdfs:comment "INCLUDE global identifier for sample, assigned by DCC" ;
  rdfs:range include:Biospecimen , xsd:string .

include:experimental_strategy a rdf:Property ;
  rdfs:label "Experimental Strategy" ;
  rdfs:comment "Experimental method used to obtain data in file (e.g. Whole genome sequencing, RNAseq, Multiplex immunoassay, Mass spec metabolomics)" , "Experimental method used to obtain data in Dataset; pipe-separated if multiple (e.g. Whole genome sequencing, RNAseq, Multiplex immunoassay, Mass spec metabolomics)" ;
  rdfs:range xsd:string .

include:drs_uri a rdf:Property ;
  rdfs:label "DRS URI" ;
  rdfs:comment "Data Repository Services API Uniform Resource Identifier" ;
  rdfs:range xsd:anyURI .

include:sample_external_id a rdf:Property ;
  rdfs:label "Sample External ID" ;
  rdfs:comment "Unique identifier for sample, assigned by data contributor. A sample is a unique biological material; two samples with two different IDs are biologically distinct." ;
  rdfs:range xsd:string .

include:file_name a rdf:Property ;
  rdfs:label "File Name" ;
  rdfs:comment "Name of file, assigned by data contributor" ;
  rdfs:range xsd:string .

include:experimental_platform a rdf:Property ;
  rdfs:label "Experimental Platform" ;
  rdfs:comment "Specific platform used to perform experiment; pipe-separated if multiple (e.g. SOMAscan, MSD, Luminex, Illumina)" ;
  rdfs:range xsd:string .

include:file_global_id a rdf:Property ;
  rdfs:label "File Global ID" ;
  rdfs:comment "INCLUDE global file identifier, assigned by DCC" ;
  rdfs:range xsd:string , include:DataFile .

include:DatasetManifest a rdfs:Class ;
  rdfs:label "Dataset Manifest" ;
  rdfs:comment "Mapping information for files in Dataset" .

include:dataset_name a rdf:Property ;
  rdfs:label "Dataset Name" ;
  rdfs:comment "Full name of the dataset, provided by contributor" ;
  rdfs:range xsd:string .

include:dataset_global_id a rdf:Property ;
  rdfs:label "Dataset Global ID" ;
  rdfs:comment "Unique Global ID for dataset, generated by DCC" ;
  rdfs:range include:Dataset , xsd:string .

include:dataset_external_id a rdf:Property ;
  rdfs:label "Dataset External ID" ;
  rdfs:comment "Unique identifier or code for dataset, if provided by contributor" ;
  rdfs:range xsd:string .

include:Biospecimen a rdfs:Class ;
  rdfs:label "Biospecimen" ;
  rdfs:comment "A Biospecimen Collected from A Participant" .

include:concentration_unit a rdf:Property ;
  rdfs:label "Concentration Unit" ;
  rdfs:comment "Unit of sample concentration" ;
  rdfs:range xsd:string .

include:concentration a rdf:Property ;
  rdfs:label "Concentration" ;
  rdfs:comment "Concentration of sample in container" ;
  rdfs:range xsd:float .

include:parent_sample_type a rdf:Property ;
  rdfs:label "Parent Sample Type" ;
  rdfs:comment "Type of biological material comprising the Parent Sample (e.g. Peripheral Whole Blood, Derived Cell Line, Saliva, Whole blood, WBCs)" ;
  rdfs:range xsd:string .

include:parent_sample_global_id a rdf:Property ;
  rdfs:label "Parent Sample Global ID" ;
  rdfs:comment "INCLUDE global identifier for the direct parent from which Sample was derived, assigned by DCC" ;
  rdfs:range xsd:string .

include:parent_sample_external_id a rdf:Property ;
  rdfs:label "Parent Sample External ID" ;
  rdfs:comment "Identifier for the direct parent from which Sample was derived, processed, pooled, etc. (if applicable); assigned by data contributor" ;
  rdfs:range xsd:string .

include:laboratory_procedure a rdf:Property ;
  rdfs:label "Laboratory Procedure" ;
  rdfs:comment "Procedure by which Sample was derived from Parent Sample (e.g. Centrifugation, RBC lysis, Lyse/fix buffer, FACS, PAXgene DNA, PAXgene RNA, Qiagen Allprep, Ficoll)" ;
  rdfs:range xsd:string .

include:collection_sample_type a rdf:Property ;
  rdfs:label "Collection Sample Type" ;
  rdfs:comment "Type of biological material comprising the Collected Sample (e.g. Whole blood, Not reported, Saliva, Derived cell line)" ;
  rdfs:range xsd:string .

include:sample_availability a rdf:Property ;
  rdfs:label "Sample Availability" ;
  rdfs:comment "Whether or not the Sample (any Container thereof) is potentially available for sharing through the Virtual Biorepository" ;
  rdfs:range include:EnumAvailability .

include:volume a rdf:Property ;
  rdfs:label "Volume" ;
  rdfs:comment "Amount of sample in container" ;
  rdfs:range xsd:float .

include:biospecimen_storage a rdf:Property ;
  rdfs:label "Biospecimen Storage" ;
  rdfs:comment "Method by which Container is stored (e.g. Minus 80 degrees Celsius, Liquid nitrogen storage)" ;
  rdfs:range xsd:string .

include:collection_global_id a rdf:Property ;
  rdfs:label "Collection Global ID" ;
  rdfs:comment "INCLUDE global identifier for the eldest sample in a lineage, assigned by DCC" ;
  rdfs:range xsd:string .

include:age_at_biospecimen_collection a rdf:Property ;
  rdfs:label "Age At Biospecimen Collection" ;
  rdfs:comment "Age in days of participant at time of biospecimen collection" ;
  rdfs:range xsd:integer .

include:container_external_id a rdf:Property ;
  rdfs:label "Container External ID" ;
  rdfs:comment "Identifier for specific container/aliquot of sample, assigned by data contributor. For example, distinct aliquots of a sample will have the same Sample ID but different Container IDs." ;
  rdfs:range xsd:string .

include:container_availability a rdf:Property ;
  rdfs:label "Container Availability" ;
  rdfs:comment "Whether or not the specific Container is potentially available for sharing through the Virtual Biorepository" ;
  rdfs:range include:EnumAvailability .

include:sample_type a rdf:Property ;
  rdfs:label "Sample Type" ;
  rdfs:comment "Type of biological material comprising the Sample (e.g. Plasma, White blood cells, Red blood cells, DNA, RNA, Peripheral blood mononuclear cells, CD4+ Tconv cells, NK cells, Monocytes, CD8+ T cells, B cells, Granulocytes, Treg cells)" ;
  rdfs:range xsd:string .

include:container_global_id a rdf:Property ;
  rdfs:label "Container Global ID" ;
  rdfs:comment "INCLUDE global identifier for specific container/aliquot of sample, assigned by DCC" ;
  rdfs:range xsd:string .

include:collection_external_id a rdf:Property ;
  rdfs:label "Collection External ID" ;
  rdfs:comment "Identifier for the eldest sample in a lineage of processed, pooled, or aliquoted samples - typically the material actually collected from the Participant. This may be the same as Parent Sample ID or Sample ID (if no processing was performed). Assigned by data contributor." ;
  rdfs:range xsd:string .

include:volume_unit a rdf:Property ;
  rdfs:label "Volume Unit" ;
  rdfs:comment "Unit of sample volume" ;
  rdfs:range xsd:string .

include:Participant a rdfs:Class ;
  rdfs:label "Participant" ;
  rdfs:comment "Demographic and clinical information about the participant" .

include:outcomes_vital_status a rdf:Property ;
  rdfs:label "Outcomes Vital Status" ;
  rdfs:comment "Whether participant is alive or dead" ;
  rdfs:range include:EnumVitalStatus .

include:father_id a rdf:Property ;
  rdfs:label "Father ID" ;
  rdfs:comment "Participant External ID for Participant's father (NA if Participant is not the proband)" ;
  rdfs:range xsd:string .

include:down_syndrome_status a rdf:Property ;
  rdfs:label "Down Syndrome Status" ;
  rdfs:comment "Down Syndrome status of participant" ;
  rdfs:range include:EnumDownSyndromeStatus .

include:sex a rdf:Property ;
  rdfs:label "Sex" ;
  rdfs:comment "Sex of Participant" ;
  rdfs:range include:EnumSex .

include:race a rdf:Property ;
  rdfs:label "Race" ;
  rdfs:comment "Race of Participant" ;
  rdfs:range include:EnumRace .

include:age_at_first_participant_engagement a rdf:Property ;
  rdfs:label "Age at First Participant Engagement" ;
  rdfs:comment "Age in days of Participant at first recorded study event (enrollment, visit, observation, sample collection, survey completion, etc.). Age at enrollment is preferred, if available." ;
  rdfs:range xsd:integer .

include:sibling_id a rdf:Property ;
  rdfs:label "Sibling ID" ;
  rdfs:comment "Participant External ID for Participant's sibling(s) (NA if Participant is not the proband)" ;
  rdfs:range xsd:string .

include:family_relationship a rdf:Property ;
  rdfs:label "Family Relationship" ;
  rdfs:comment "Relationship of Participant to proband" ;
  rdfs:range include:EnumFamilyRelationship .

include:other_family_member_id a rdf:Property ;
  rdfs:label "Other Family Member ID" ;
  rdfs:comment "Participant External ID for Participant's other family members (NA if Participant is not the proband)" ;
  rdfs:range xsd:string .

include:age_at_last_vital_status a rdf:Property ;
  rdfs:label "Age at Last Vital Status" ;
  rdfs:comment "Age in days when participant's vital status was last recorded" ;
  rdfs:range xsd:integer .

include:family_type a rdf:Property ;
  rdfs:label "Family Type" ;
  rdfs:comment "Structure of family members participating in the study" ;
  rdfs:range include:EnumFamilyType .

include:mother_id a rdf:Property ;
  rdfs:label "Mother ID" ;
  rdfs:comment "Participant External ID for Participant's mother (NA if Participant is not the proband)" ;
  rdfs:range xsd:string .

include:family_id a rdf:Property ;
  rdfs:label "Family ID" ;
  rdfs:comment "Unique identifer for family to which Participant belongs, assigned by data contributor" ;
  rdfs:range xsd:string .

include:ethnicity a rdf:Property ;
  rdfs:label "Ethnicity" ;
  rdfs:comment "Ethnicity of Participant" ;
  rdfs:range include:EnumEthnicity .

include:first_participant_engagement_event a rdf:Property ;
  rdfs:label "First Participant Engagement Event" ;
  rdfs:comment "Event for which Age at First Participant Engagement is given (e.g. enrollment, visit, observation, sample collection, survey completion, etc.). Age at enrollment is preferred, if available." ;
  rdfs:range xsd:string .

include:Study a rdfs:Class ;
  rdfs:label "Study" ;
  rdfs:comment "General information about the study" .

include:program a rdf:Property ;
  rdfs:label "Program" ;
  rdfs:comment "Funding source(s) for the study (pipe-separated if multiple)" ;
  rdfs:range include:EnumProgram .

include:study_title a rdf:Property ;
  rdfs:label "Study Title" ;
  rdfs:comment "Full title of the study" ;
  rdfs:range xsd:string .

include:acknowledgments a rdf:Property ;
  rdfs:label "Acknowledgments" ;
  rdfs:comment "Funding statement and acknowledgments for this study" ;
  rdfs:range xsd:string .

include:study_website a rdf:Property ;
  rdfs:label "Study Website" ;
  rdfs:comment "Website for the study" ;
  rdfs:range xsd:anyURI .

include:guid_type a rdf:Property ;
  rdfs:label "GUID Type" ;
  rdfs:comment "System used to generate globally unique identifiers (GUIDs)" ;
  rdfs:range include:EnumGuidType .

include:guid_mapped a rdf:Property ;
  rdfs:label "GUIDs Mapped?" ;
  rdfs:comment "For studies using NDAR GUIDs, have the GUIDs been added to the INCLUDE GUID Mapping File?" ;
  rdfs:range xsd:boolean .

include:vbr_url a rdf:Property ;
  rdfs:label "VBR URL" ;
  rdfs:comment "Link to Virtual Biorepository request form, if participating" ;
  rdfs:range xsd:anyURI .

include:expected_number_of_participants a rdf:Property ;
  rdfs:label "Expected Number of Participants" ;
  rdfs:comment "Expected number of participants in this study (or actual number, if data has been submitted to INCLUDE DCC). If additional explanation is needed, please add to Study Description field." , "Expected number of participants in this Dataset (or actual number, if data has been submitted to INCLUDE DCC). If additional explanation is needed, please add to Dataset Description field." ;
  rdfs:range xsd:integer .

include:vbr_readme a rdf:Property ;
  rdfs:label "VBR Readme" ;
  rdfs:comment "Instructions for contacting or requesting samples from Virtual Biorepository, if participating" ;
  rdfs:range xsd:string .

include:study_design a rdf:Property ;
  rdfs:label "Study Design" ;
  rdfs:comment "Overall design of study, including whether it is longitudinal and whether family members/unrelated controls are also enrolled" ;
  rdfs:range include:EnumStudyDesign .

include:study_contact_name a rdf:Property ;
  rdfs:label "Study Contact Name" ;
  rdfs:comment "Name of contact person for this study; pipe-separated if multiple" ;
  rdfs:range xsd:string .

include:study_contact_institution a rdf:Property ;
  rdfs:label "Study Contact Institution" ;
  rdfs:comment "Institution of contact person for this study; pipe-separated if multiple" ;
  rdfs:range xsd:string .

include:doi_citation a rdf:Property ;
  rdfs:label "DOI Citation" ;
  rdfs:comment "Bibliographic citation for DOI, generated by DataCite" ;
  rdfs:range xsd:string .

include:publication a rdf:Property ;
  rdfs:label "Publication" ;
  rdfs:comment "URL for publication(s) describing the study's rationale and methodology (PubMed Central preferred but not required; pipe-separated if multiple)" , "URL for publication(s) describing the Dataset's rationale and methodology (PubMed Central preferred but not required; pipe-separated if multiple)" ;
  rdfs:range xsd:anyURI .

include:citation_statement a rdf:Property ;
  rdfs:label "Citation Statement" ;
  rdfs:comment "Statement that secondary data users should use to acknowledge use of this dataset. E.g., \"The results analyzed and <published or shown> here are based in whole or in part upon data generated by the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project <insert accession number(s) and/or study DOI(s)>, and were accessed from the INCLUDE Data Hub and <insert other database(s)>.\"" ;
  rdfs:range xsd:string .

include:clinical_data_source_type a rdf:Property ;
  rdfs:label "Clinical Data Source Type" ;
  rdfs:comment "Source(s) of data collected from study participants; pipe-separated if multiple" ;
  rdfs:range include:EnumClinicalDataSourceType .

include:dbgap a rdf:Property ;
  rdfs:label "dbGaP" ;
  rdfs:comment "dbGaP \"phs\" accession code(s) associated with this Study, either for access or informational purposes (pipe-separated if multiple)" , "dbGaP \"phs\" accession code(s) required to access the files in this Dataset, if applicable (pipe-separated if multiple)" ;
  rdfs:range xsd:string .

include:study_description a rdf:Property ;
  rdfs:label "Study Description" ;
  rdfs:comment "Brief description of the study (2-4 sentences)" ;
  rdfs:range xsd:string .

include:selection_criteria a rdf:Property ;
  rdfs:label "Selection Criteria" ;
  rdfs:comment "Brief description of inclusion and/or exclusion criteria for the study" ;
  rdfs:range xsd:string .

include:participant_lifespan_stage a rdf:Property ;
  rdfs:label "Participant Lifespan Stage" ;
  rdfs:comment "Focus age group(s) of the study population; pipe-separated if multiple" ;
  rdfs:range include:EnumParticipantLifespanStage .

include:doi a rdf:Property ;
  rdfs:label "DOI" ;
  rdfs:comment "Unique Digital Object Identifier for each Study and Dataset, minted by the DCC using DataCite" ;
  rdfs:range xsd:anyURI .

include:vbr_email a rdf:Property ;
  rdfs:label "VBR Email" ;
  rdfs:comment "Email address for Virtual Biorepository requests/inquiries, if participating" ;
  rdfs:range xsd:string .

include:principal_investigator_name a rdf:Property ;
  rdfs:label "Principal Investigator Name" ;
  rdfs:comment "Name(s) of Principal Investigator(s) of this study; pipe-separated if multiple" ;
  rdfs:range xsd:string .

include:research_domain a rdf:Property ;
  rdfs:label "Research Domain" ;
  rdfs:comment "Main research domain(s) of the study, other than Down syndrome; pipe-separated if multiple" ;
  rdfs:range include:EnumResearchDomain .

include:study_contact_email a rdf:Property ;
  rdfs:label "Study Contact Email" ;
  rdfs:comment "Email address of contact person for this study; pipe-separated if multiple" ;
  rdfs:range xsd:string .

include:Dataset a rdfs:Class ;
  rdfs:label "Dataset" ;
  rdfs:comment "Information about a specific grouping of data files" .

include:dataset_description a rdf:Property ;
  rdfs:label "Dataset Description" ;
  rdfs:comment "Brief additional notes about the dataset (1-3 sentences) that are not already captured in the other fields" ;
  rdfs:range xsd:string .

include:other_access_authority a rdf:Property ;
  rdfs:label "Other Access Authority" ;
  rdfs:comment "Email or URL for dataset's Access Authority, if not dbGaP" ;
  rdfs:range xsd:string .

include:other_repository a rdf:Property ;
  rdfs:label "Other Repository" ;
  rdfs:comment "URL if dataset is already deposited in a public repository other than dbGaP (e.g. LONI, Metabolomics Workbench, etc.)" ;
  rdfs:range xsd:anyURI .

include:is_harmonized a rdf:Property ;
  rdfs:label "Is Harmonized" ;
  rdfs:comment "All of the elements in this Dataset are harmonized and available in the INCLUDE Data Hub" ;
  rdfs:range xsd:boolean .

include:dataset_manifest_location a rdf:Property ;
  rdfs:label "Dataset Manifest Location" ;
  rdfs:comment "Location of associated Dataset Manifest" ;
  rdfs:range xsd:string .

include:data_collection_start_year a rdf:Property ;
  rdfs:label "Data Collection Start Year" ;
  rdfs:comment "Year that data collection started" ;
  rdfs:range xsd:string .

include:expected_number_of_files a rdf:Property ;
  rdfs:label "Expected Number of Files" ;
  rdfs:comment "Expected number of files associated with this dataset, including dictionaries. If additional explanation is needed, please add to Dataset Description field." ;
  rdfs:range xsd:integer .

include:access_requirements a rdf:Property ;
  rdfs:label "Access Requirements" ;
  rdfs:comment "Data access requirements, as defined in the GA4GH Data Use Ontology (DUO; can list more than one, pipe separated)" ;
  rdfs:range xsd:string .

include:data_collection_end_year a rdf:Property ;
  rdfs:label "Data Collection End Year" ;
  rdfs:comment "Year that data collection ended" ;
  rdfs:range xsd:string .

include:access_limitations a rdf:Property ;
  rdfs:label "Access Limitations" ;
  rdfs:comment "Data access limitations, as defined in the GA4GH Data Use Ontology (DUO; can list more than one, pipe separated)" ;
  rdfs:range xsd:string .

include:EnumVitalStatus a rdfs:Class .

<http://purl.obolibrary.org/obo/ncitC28554> a include:EnumVitalStatus ;
  rdfs:label "Dead" .

<http://purl.obolibrary.org/obo/ncitC37987> a include:EnumVitalStatus ;
  rdfs:label "Alive" .

<http://purl.obolibrary.org/obo/ncitC17998> a include:EnumVitalStatus , include:EnumEthnicity , include:EnumSex , include:EnumRace ;
  rdfs:label "Unknown or not available" , "Unknown" .

include:EnumFamilyType a rdfs:Class .

include:EnumFamilyType.CONTROL_ONLY a include:EnumFamilyType ;
  rdfs:label "Control-only" ;
  rdfs:comment "Unrelated control, no Down syndrome family members" .

include:EnumFamilyType.DUO a include:EnumFamilyType ;
  rdfs:label "Duo" ;
  rdfs:comment "Proband + one parent" .

include:EnumFamilyType.OTHER a include:EnumFamilyType ;
  rdfs:label "Other" ;
  rdfs:comment "Other family structure, e.g. one parent + twins" .

include:EnumFamilyType.PROBAND_ONLY a include:EnumFamilyType ;
  rdfs:label "Proband-only" ;
  rdfs:comment "Proband only, no family members participating in study" .

include:EnumFamilyType.TRIO a include:EnumFamilyType ;
  rdfs:label "Trio" ;
  rdfs:comment "Proband + two parents" .

include:EnumFamilyType.TRIO_PLUS a include:EnumFamilyType ;
  rdfs:label "Trio Plus" ;
  rdfs:comment "Proband + two parents + other relatives" .

include:EnumDownSyndromeStatus a rdfs:Class .

include:EnumDownSyndromeStatus.D_21 a include:EnumDownSyndromeStatus ;
  rdfs:label "D21" ;
  rdfs:comment "Disomy 21 (euploid)" .

<http://purl.obolibrary.org/obo/mondo0008608> a include:EnumDownSyndromeStatus ;
  rdfs:label "T21" ;
  rdfs:comment "Trisomy 21 (Down syndrome)" .

include:EnumConditionDataSource a rdfs:Class .

include:EnumConditionDataSource.CLINICAL a include:EnumConditionDataSource ;
  rdfs:label "Clinical" ;
  rdfs:comment "Information about condition was obtained from medical records or reported by investigator" .

include:EnumConditionDataSource.SELF_REPORTED a include:EnumConditionDataSource ;
  rdfs:label "Self-reported" ;
  rdfs:comment "Information about condition was reported by participant or family member" .

include:EnumParticipantLifespanStage a rdfs:Class .

include:EnumParticipantLifespanStage.FETAL a include:EnumParticipantLifespanStage ;
  rdfs:label "Fetal" .

include:EnumParticipantLifespanStage.NEONATAL a include:EnumParticipantLifespanStage ;
  rdfs:label "Neonatal" ;
  rdfs:comment "0-28 days old" .

include:EnumParticipantLifespanStage.PEDIATRIC a include:EnumParticipantLifespanStage ;
  rdfs:label "Pediatric" ;
  rdfs:comment "Birth-17 years old" .

include:EnumParticipantLifespanStage.ADULT a include:EnumParticipantLifespanStage ;
  rdfs:label "Adult" ;
  rdfs:comment "18+ years old" .

include:EnumFamilyRelationship a rdfs:Class .

<http://purl.obolibrary.org/obo/ncitC64435> a include:EnumFamilyRelationship ;
  rdfs:label "Proband" ;
  rdfs:comment "The first affected family member to join the study" .

<http://purl.obolibrary.org/obo/ncitC25174> a include:EnumFamilyRelationship ;
  rdfs:label "Father" .

<http://purl.obolibrary.org/obo/ncitC25189> a include:EnumFamilyRelationship ;
  rdfs:label "Mother" .

<http://purl.obolibrary.org/obo/ncitC25204> a include:EnumFamilyRelationship ;
  rdfs:label "Sibling" .

<http://purl.obolibrary.org/obo/ncitC21480> a include:EnumFamilyRelationship ;
  rdfs:label "Other relative" .

<http://purl.obolibrary.org/obo/ncitC25328> a include:EnumFamilyRelationship ;
  rdfs:label "Unrelated control" .

include:EnumStudyCode a rdfs:Class .

include:EnumStudyCode.AADSC a include:EnumStudyCode ;
  rdfs:label "AADSC" .

include:EnumStudyCode.ABC_DS a include:EnumStudyCode ;
  rdfs:label "ABC-DS" .

include:EnumStudyCode.ADS a include:EnumStudyCode ;
  rdfs:label "ADS" .

include:EnumStudyCode.AECOM_DS a include:EnumStudyCode ;
  rdfs:label "AECOM-DS" .

include:EnumStudyCode.BEST_21 a include:EnumStudyCode ;
  rdfs:label "BEST21" .

include:EnumStudyCode.BRAINPOWER a include:EnumStudyCode ;
  rdfs:label "BrainPower" .

include:EnumStudyCode.BRI_DSR a include:EnumStudyCode ;
  rdfs:label "BRI-DSR" .

include:EnumStudyCode.CCDS a include:EnumStudyCode ;
  rdfs:label "CCDS" .

include:EnumStudyCode.CHILD_DS a include:EnumStudyCode ;
  rdfs:label "CHILD-DS" .

include:EnumStudyCode.CHARGE_DS a include:EnumStudyCode ;
  rdfs:label "CHARGE-DS" .

include:EnumStudyCode.DECIDAS a include:EnumStudyCode ;
  rdfs:label "DECIDAS" .

include:EnumStudyCode.DS_ARC a include:EnumStudyCode ;
  rdfs:label "DS-ARC" .

include:EnumStudyCode.DS_BRAIN a include:EnumStudyCode ;
  rdfs:label "DS-Brain" .

include:EnumStudyCode.DS_COG_ALL a include:EnumStudyCode ;
  rdfs:label "DS-COG-ALL" .

include:EnumStudyCode.DS_COG_AML a include:EnumStudyCode ;
  rdfs:label "DS-COG-AML" .

include:EnumStudyCode.DS_DETERMINED a include:EnumStudyCode ;
  rdfs:label "DS-DETERMINED" .

include:EnumStudyCode.DS_HOME a include:EnumStudyCode ;
  rdfs:label "DS-HOME" .

include:EnumStudyCode.DS_HSAT a include:EnumStudyCode ;
  rdfs:label "DS-HSAT" .

include:EnumStudyCode.DS_ISP a include:EnumStudyCode ;
  rdfs:label "DS-ISP" .

include:EnumStudyCode.DS_NEXUS a include:EnumStudyCode ;
  rdfs:label "DS-Nexus" .

include:EnumStudyCode.DS_PALS a include:EnumStudyCode ;
  rdfs:label "DS-PALS" .

include:EnumStudyCode.DS_PCGC a include:EnumStudyCode ;
  rdfs:label "DS-PCGC" .

include:EnumStudyCode.DS_SLEEP a include:EnumStudyCode ;
  rdfs:label "DS-Sleep" .

include:EnumStudyCode.DS_VITE a include:EnumStudyCode ;
  rdfs:label "DS-VitE" .

include:EnumStudyCode.DS_360_CHD a include:EnumStudyCode ;
  rdfs:label "DS360-CHD" .

include:EnumStudyCode.DSC a include:EnumStudyCode ;
  rdfs:label "DSC" .

include:EnumStudyCode.DSPOSTBFMULTI a include:EnumStudyCode ;
  rdfs:label "DSpostBFmulti" .

include:EnumStudyCode.DSRRS a include:EnumStudyCode ;
  rdfs:label "DSRRS" .

include:EnumStudyCode.ECODS a include:EnumStudyCode ;
  rdfs:label "ECODS" .

include:EnumStudyCode.EXCEEDS a include:EnumStudyCode ;
  rdfs:label "EXcEEDS" .

include:EnumStudyCode.HTP a include:EnumStudyCode ;
  rdfs:label "HTP" .

include:EnumStudyCode.IBIS_DS a include:EnumStudyCode ;
  rdfs:label "IBIS-DS" .

include:EnumStudyCode.JAKI_DS a include:EnumStudyCode ;
  rdfs:label "JAKi-DS" .

include:EnumStudyCode.OPTIMAL a include:EnumStudyCode ;
  rdfs:label "OPTimal" .

include:EnumStudyCode.TEAM_DS a include:EnumStudyCode ;
  rdfs:label "TEAM-DS" .

include:EnumStudyCode.TOMI a include:EnumStudyCode ;
  rdfs:label "TOMI" .

include:EnumStudyCode.TRC_DS a include:EnumStudyCode ;
  rdfs:label "TRC-DS" .

include:EnumStudyCode.X_01_DESMITH a include:EnumStudyCode ;
  rdfs:label "X01-deSmith" .

include:EnumStudyCode.X_01_HAKONARSON a include:EnumStudyCode ;
  rdfs:label "X01-Hakonarson" .

include:EnumEthnicity a rdfs:Class .

<http://purl.obolibrary.org/obo/ncitC17459> a include:EnumEthnicity ;
  rdfs:label "Hispanic or Latino" .

<http://purl.obolibrary.org/obo/ncitC41222> a include:EnumEthnicity ;
  rdfs:label "Not Hispanic or Latino" .

<http://purl.obolibrary.org/obo/ncitC132222> a include:EnumEthnicity , include:EnumRace ;
  rdfs:label "Prefer not to answer" .

include:EnumSex a rdfs:Class .

<http://purl.obolibrary.org/obo/ncitC16576> a include:EnumSex ;
  rdfs:label "Female" .

<http://purl.obolibrary.org/obo/ncitC20197> a include:EnumSex ;
  rdfs:label "Male" .

<http://purl.obolibrary.org/obo/ncitC17649> a include:EnumSex , include:EnumRace ;
  rdfs:label "Other" .

include:EnumAvailability a rdfs:Class .

include:EnumAvailability.AVAILABLE a include:EnumAvailability ;
  rdfs:label "Available" ;
  rdfs:comment "Sample or Container is potentially available to be requested through the Virtual Biorepository (see VBR contact info in Study page)" .

include:EnumAvailability.UNAVAILABLE a include:EnumAvailability ;
  rdfs:label "Unavailable" ;
  rdfs:comment "Sample or Container either was available through Virtual Biorepository but has been used up, or is part of a study that is not participating in the VBR" .

include:EnumConditionStatus a rdfs:Class .

include:EnumConditionStatus.CURRENT a include:EnumConditionStatus ;
  rdfs:label "Current" ;
  rdfs:comment "Condition is ongoing" .

include:EnumConditionStatus.RESOLVED a include:EnumConditionStatus ;
  rdfs:label "Resolved" ;
  rdfs:comment "Condition has been resolved" .

include:EnumConditionStatus.HISTORY_OF a include:EnumConditionStatus ;
  rdfs:label "History Of" ;
  rdfs:comment "This is a general history of the condition, without known dates" .

include:EnumStudyDesign a rdfs:Class .

include:EnumStudyDesign.CASE_CONTROL a include:EnumStudyDesign ;
  rdfs:label "Case-Control" .

include:EnumStudyDesign.CASE_SET a include:EnumStudyDesign ;
  rdfs:label "Case Set" .

include:EnumStudyDesign.CONTROL_SET a include:EnumStudyDesign ;
  rdfs:label "Control Set" .

include:EnumStudyDesign.CLINICAL_TRIAL a include:EnumStudyDesign ;
  rdfs:label "Clinical Trial" .

include:EnumStudyDesign.CROSS_SECTIONAL a include:EnumStudyDesign ;
  rdfs:label "Cross-Sectional" .

include:EnumStudyDesign.FAMILY_TWINS_TRIOS a include:EnumStudyDesign ;
  rdfs:label "Family/Twins/Trios" .

include:EnumStudyDesign.INTERVENTIONAL a include:EnumStudyDesign ;
  rdfs:label "Interventional" .

include:EnumStudyDesign.LONGITUDINAL a include:EnumStudyDesign ;
  rdfs:label "Longitudinal" .

include:EnumStudyDesign.TUMOR_VS_MATCHED_NORMAL a include:EnumStudyDesign ;
  rdfs:label "Tumor vs Matched Normal" .

include:EnumProgram a rdfs:Class .

include:EnumProgram.INCLUDE a include:EnumProgram ;
  rdfs:label "INCLUDE" .

include:EnumProgram.KF a include:EnumProgram ;
  rdfs:label "KF" .

include:EnumProgram.OTHER a include:EnumProgram ;
  rdfs:label "Other" .

include:EnumClinicalDataSourceType a rdfs:Class .

include:EnumClinicalDataSourceType.MEDICAL_RECORD a include:EnumClinicalDataSourceType ;
  rdfs:label "Medical Record" ;
  rdfs:comment "Data obtained directly from medical record" .

include:EnumClinicalDataSourceType.INVESTIGATOR_ASSESSMENT a include:EnumClinicalDataSourceType ;
  rdfs:label "Investigator Assessment" ;
  rdfs:comment "Data obtained by examination, interview, etc. with investigator" .

include:EnumClinicalDataSourceType.PARTICIPANT_OR_CAREGIVER_REPORT a include:EnumClinicalDataSourceType ;
  rdfs:label "Participant or Caregiver Report" ;
  rdfs:comment "Data obtained from survey, questionnaire, etc. filled out by participant or caregiver" .

include:EnumClinicalDataSourceType.OTHER a include:EnumClinicalDataSourceType ;
  rdfs:label "Other" ;
  rdfs:comment "Data obtained from other source, such as tissue bank" .

include:EnumClinicalDataSourceType.UNKNOWN a include:EnumClinicalDataSourceType ;
  rdfs:label "Unknown" .

include:EnumGuidType a rdfs:Class .

include:EnumGuidType.NDAR a include:EnumGuidType ;
  rdfs:label "NDAR" ;
  rdfs:comment "GUID generated by NIMH Data Archive (NDA) GUID tool" .

include:EnumGuidType.OTHER a include:EnumGuidType ;
  rdfs:label "Other" ;
  rdfs:comment "GUID generated by other system" .

include:EnumGuidType.NO_GUID a include:EnumGuidType ;
  rdfs:label "No GUID" ;
  rdfs:comment "No GUIDs used in this study" .

include:EnumConditionInterpretation a rdfs:Class .

include:EnumConditionInterpretation.OBSERVED a include:EnumConditionInterpretation ;
  rdfs:label "Observed" ;
  rdfs:comment "Condition was observed or reported (this will be the case for most conditions)" .

include:EnumConditionInterpretation.NOT_OBSERVED a include:EnumConditionInterpretation ;
  rdfs:label "Not Observed" ;
  rdfs:comment "Participant was specifically examined or medical record queried for condition and found to be negative" .

include:EnumDataCategory a rdfs:Class .

include:EnumDataCategory.UNHARMONIZED_DEMOGRAPHIC_CLINICAL_DATA a include:EnumDataCategory ;
  rdfs:label "Unharmonized Demographic/Clinical Data" .

include:EnumDataCategory.HARMONIZED_DEMOGRAPHIC_CLINICAL_DATA a include:EnumDataCategory ;
  rdfs:label "Harmonized Demographic/Clinical Data" .

include:EnumDataCategory.GENOMICS a include:EnumDataCategory ;
  rdfs:label "Genomics" .

include:EnumDataCategory.TRANSCRIPTOMICS a include:EnumDataCategory ;
  rdfs:label "Transcriptomics" .

include:EnumDataCategory.EPIGENOMICS a include:EnumDataCategory ;
  rdfs:label "Epigenomics" .

include:EnumDataCategory.PROTEOMICS a include:EnumDataCategory ;
  rdfs:label "Proteomics" .

include:EnumDataCategory.METABOLOMICS a include:EnumDataCategory ;
  rdfs:label "Metabolomics" .

include:EnumDataCategory.COGNITIVE_BEHAVIORAL a include:EnumDataCategory ;
  rdfs:label "Cognitive/Behavioral" .

include:EnumDataCategory.IMMUNE_PROFILING a include:EnumDataCategory ;
  rdfs:label "Immune Profiling" .

include:EnumDataCategory.IMAGING a include:EnumDataCategory ;
  rdfs:label "Imaging" .

include:EnumDataCategory.MICROBIOME a include:EnumDataCategory ;
  rdfs:label "Microbiome" .

include:EnumDataCategory.FITNESS a include:EnumDataCategory ;
  rdfs:label "Fitness" .

include:EnumDataCategory.PHYSICAL_ACTIVITY a include:EnumDataCategory ;
  rdfs:label "Physical Activity" .

include:EnumDataCategory.OTHER a include:EnumDataCategory ;
  rdfs:label "Other" .

include:EnumDataCategory.SLEEP_STUDY a include:EnumDataCategory ;
  rdfs:label "Sleep Study" .

include:EnumResearchDomain a rdfs:Class .

<http://id.nlm.nih.gov/mesh/D001520> a include:EnumResearchDomain ;
  rdfs:label "Behavior and Behavior Mechanisms" .

<http://id.nlm.nih.gov/mesh/D006330> a include:EnumResearchDomain ;
  rdfs:label "Congenital Heart Defects" .

<http://id.nlm.nih.gov/mesh/D007154> a include:EnumResearchDomain ;
  rdfs:label "Immune System Diseases" .

<http://id.nlm.nih.gov/mesh/D006402> a include:EnumResearchDomain ;
  rdfs:label "Hematologic Diseases" .

include:EnumResearchDomain.NEURODEVELOPMENT a include:EnumResearchDomain ;
  rdfs:label "Neurodevelopment" .

<http://id.nlm.nih.gov/mesh/D012893> a include:EnumResearchDomain ;
  rdfs:label "Sleep Wake Disorders" .

<http://id.nlm.nih.gov/mesh/D013568> a include:EnumResearchDomain ;
  rdfs:label "All Co-occurring Conditions" .

<http://id.nlm.nih.gov/mesh/D010809> a include:EnumResearchDomain ;
  rdfs:label "Physical Fitness" .

include:EnumResearchDomain.OTHER a include:EnumResearchDomain ;
  rdfs:label "Other" .

include:EnumDataAccess a rdfs:Class .

include:EnumDataAccess.CONTROLLED a include:EnumDataAccess ;
  rdfs:label "Controlled" .

include:EnumDataAccess.OPEN a include:EnumDataAccess ;
  rdfs:label "Open" .

include:EnumDataAccess.REGISTERED a include:EnumDataAccess ;
  rdfs:label "Registered" .

include:EnumRace a rdfs:Class .

<http://purl.obolibrary.org/obo/ncitC41259> a include:EnumRace ;
  rdfs:label "American Indian or Alaska Native" .

<http://purl.obolibrary.org/obo/ncitC41260> a include:EnumRace ;
  rdfs:label "Asian" .

<http://purl.obolibrary.org/obo/ncitC16352> a include:EnumRace ;
  rdfs:label "Black or African American" .

<http://purl.obolibrary.org/obo/ncitC67109> a include:EnumRace ;
  rdfs:label "More than one race" .

<http://purl.obolibrary.org/obo/ncitC41219> a include:EnumRace ;
  rdfs:label "Native Hawaiian or Other Pacific Islander" .

<http://purl.obolibrary.org/obo/ncitC41261> a include:EnumRace ;
  rdfs:label "White" .

<http://purl.obolibrary.org/obo/ncitC161419> a include:EnumRace ;
  rdfs:label "East Asian" ;
  rdfs:comment "UK only; do not use for US data" .

<http://purl.obolibrary.org/obo/ncitC126531> a include:EnumRace ;
  rdfs:label "Latin American" ;
  rdfs:comment "UK only; do not use for US data" .

<http://purl.obolibrary.org/obo/ncitC43866> a include:EnumRace ;
  rdfs:label "Middle Eastern or North African" ;
  rdfs:comment "UK only; do not use for US data" .

<http://purl.obolibrary.org/obo/ncitC41263> a include:EnumRace ;
  rdfs:label "South Asian" ;
  rdfs:comment "UK only; do not use for US data" .