PREFIX owl: PREFIX rdf: PREFIX rdfs: PREFIX xsd: PREFIX include: PREFIX linkml: PREFIX schema: PREFIX mesh: PREFIX MONDO: PREFIX NCIT: PREFIX skos: PREFIX sh: PREFIX vann: a owl:Ontology ; vann:preferredNamespacePrefix "include" ; vann:preferredNamespaceUri "https://w3id.org/include/"^^xsd:anyURI ; sh:declare [ sh:prefix "include" ; sh:namespace "https://w3id.org/include/"^^xsd:anyURI ] , [ sh:prefix "linkml" ; sh:namespace "https://w3id.org/linkml/"^^xsd:anyURI ] , [ sh:prefix "schema" ; sh:namespace "http://schema.org/"^^xsd:anyURI ] , [ sh:prefix "mesh" ; sh:namespace "http://id.nlm.nih.gov/mesh/"^^xsd:anyURI ] , [ sh:prefix "MONDO" ; sh:namespace "http://purl.obolibrary.org/obo/mondo"^^xsd:anyURI ] , [ sh:prefix "NCIT" ; sh:namespace "http://purl.obolibrary.org/obo/ncit"^^xsd:anyURI ] . include:Study a owl:Class ; rdfs:label "Study" ; rdfs:comment "General information about the study" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty include:study_code ; owl:allValuesFrom include:EnumStudyCode ] , [ a owl:Restriction ; owl:onProperty include:study_code ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:study_title ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:study_title ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:program ; owl:allValuesFrom include:EnumProgram ] , [ a owl:Restriction ; owl:onProperty include:program ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:study_description ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:study_description ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:principal_investigator_name ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:principal_investigator_name ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:study_contact_name ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:study_contact_name ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:study_contact_institution ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:study_contact_institution ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:study_contact_email ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:study_contact_email ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:vbr_email ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:vbr_email ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:vbr_url ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:vbr_readme ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:vbr_readme ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:research_domain ; owl:allValuesFrom include:EnumResearchDomain ] , [ a owl:Restriction ; owl:onProperty include:research_domain ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_lifespan_stage ; owl:allValuesFrom include:EnumParticipantLifespanStage ] , [ a owl:Restriction ; owl:onProperty include:participant_lifespan_stage ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:selection_criteria ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:selection_criteria ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:study_design ; owl:allValuesFrom include:EnumStudyDesign ] , [ a owl:Restriction ; owl:onProperty include:study_design ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:clinical_data_source_type ; owl:allValuesFrom include:EnumClinicalDataSourceType ] , [ a owl:Restriction ; owl:onProperty include:clinical_data_source_type ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_category ; owl:allValuesFrom include:EnumDataCategory ] , [ a owl:Restriction ; owl:onProperty include:data_category ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:study_website ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dbgap ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:publication ; owl:allValuesFrom owl:Thing ] , [ a owl:Restriction ; owl:onProperty include:expected_number_of_participants ; owl:allValuesFrom xsd:integer ] , [ a owl:Restriction ; owl:onProperty include:expected_number_of_participants ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:guid_type ; owl:allValuesFrom include:EnumGuidType ] , [ a owl:Restriction ; owl:onProperty include:guid_type ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:guid_mapped ; owl:allValuesFrom xsd:boolean ] , [ a owl:Restriction ; owl:onProperty include:guid_mapped ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:acknowledgments ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:citation_statement ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:doi ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:doi_citation ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:doi_citation ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] . include:Dataset a owl:Class ; rdfs:label "Dataset" ; rdfs:comment "Information about a specific grouping of data files" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty include:study_code ; owl:allValuesFrom include:Study ] , [ a owl:Restriction ; owl:onProperty include:study_code ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_name ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:dataset_name ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_description ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:dataset_description ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_global_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:dataset_global_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:dataset_external_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:expected_number_of_participants ; owl:allValuesFrom xsd:integer ] , [ a owl:Restriction ; owl:onProperty include:expected_number_of_participants ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:expected_number_of_files ; owl:allValuesFrom xsd:integer ] , [ a owl:Restriction ; owl:onProperty include:expected_number_of_files ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_collection_start_year ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:data_collection_start_year ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_collection_end_year ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:data_collection_end_year ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_category ; owl:allValuesFrom include:EnumDataCategory ] , [ a owl:Restriction ; owl:onProperty include:data_category ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_type ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:experimental_strategy ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:experimental_platform ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:publication ; owl:allValuesFrom owl:Thing ] , [ a owl:Restriction ; owl:onProperty include:access_limitations ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:access_limitations ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:access_requirements ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:access_requirements ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dbgap ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:other_repository ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:other_access_authority ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:other_access_authority ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:is_harmonized ; owl:allValuesFrom xsd:boolean ] , [ a owl:Restriction ; owl:onProperty include:is_harmonized ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_manifest_location ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:dataset_manifest_location ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:doi ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:doi_citation ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:doi_citation ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] . include:DatasetManifest a owl:Class ; rdfs:label "Dataset Manifest" ; rdfs:comment "Mapping information for files in Dataset" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty include:study_code ; owl:allValuesFrom include:Study ] , [ a owl:Restriction ; owl:onProperty include:study_code ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_name ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:dataset_name ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_global_id ; owl:allValuesFrom include:Dataset ] , [ a owl:Restriction ; owl:onProperty include:dataset_global_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:dataset_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:dataset_external_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_name ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_name ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_global_id ; owl:allValuesFrom include:DataFile ] , [ a owl:Restriction ; owl:onProperty include:file_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] . include:Participant a owl:Class ; rdfs:label "Participant" ; rdfs:comment "Demographic and clinical information about the participant" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty include:study_code ; owl:allValuesFrom include:Study ] , [ a owl:Restriction ; owl:onProperty include:study_code ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:minCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:family_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:family_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:family_type ; owl:allValuesFrom include:EnumFamilyType ] , [ a owl:Restriction ; owl:onProperty include:family_type ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:father_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:father_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:mother_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:mother_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sibling_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:sibling_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:other_family_member_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:other_family_member_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:family_relationship ; owl:allValuesFrom include:EnumFamilyRelationship ] , [ a owl:Restriction ; owl:onProperty include:family_relationship ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sex ; owl:allValuesFrom include:EnumSex ] , [ a owl:Restriction ; owl:onProperty include:sex ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:race ; owl:allValuesFrom include:EnumRace ] , [ a owl:Restriction ; owl:onProperty include:race ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:ethnicity ; owl:allValuesFrom include:EnumEthnicity ] , [ a owl:Restriction ; owl:onProperty include:ethnicity ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:down_syndrome_status ; owl:allValuesFrom include:EnumDownSyndromeStatus ] , [ a owl:Restriction ; owl:onProperty include:down_syndrome_status ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:age_at_first_participant_engagement ; owl:allValuesFrom [ a rdfs:Datatype ; owl:onDatatype xsd:integer ; owl:withRestrictions ( _:o135 _:o136 ) ] ] , [ a owl:Restriction ; owl:onProperty include:age_at_first_participant_engagement ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:first_participant_engagement_event ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:first_participant_engagement_event ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:outcomes_vital_status ; owl:allValuesFrom include:EnumVitalStatus ] , [ a owl:Restriction ; owl:onProperty include:outcomes_vital_status ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:age_at_last_vital_status ; owl:allValuesFrom [ a rdfs:Datatype ; owl:onDatatype xsd:integer ; owl:withRestrictions ( _:o144 _:o145 ) ] ] , [ a owl:Restriction ; owl:onProperty include:age_at_last_vital_status ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] . _:o135 xsd:minInclusive 0 . _:o136 xsd:maxInclusive 33000 . _:o144 xsd:minInclusive 0 . _:o145 xsd:maxInclusive 33000 . include:Condition a owl:Class ; rdfs:label "Condition" ; rdfs:comment "Co-occurring conditions and other observations for the participant" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty include:study_code ; owl:allValuesFrom include:Study ] , [ a owl:Restriction ; owl:onProperty include:study_code ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:allValuesFrom include:Participant ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:event_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:event_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:event_type ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:event_type ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:condition_measure_source_text ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:condition_measure_source_text ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:age_at_condition_measure_observation ; owl:allValuesFrom [ a rdfs:Datatype ; owl:onDatatype xsd:integer ; owl:withRestrictions ( _:o161 _:o162 ) ] ] , [ a owl:Restriction ; owl:onProperty include:age_at_condition_measure_observation ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:condition_interpretation ; owl:allValuesFrom include:EnumConditionInterpretation ] , [ a owl:Restriction ; owl:onProperty include:condition_interpretation ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:condition_status ; owl:allValuesFrom include:EnumConditionStatus ] , [ a owl:Restriction ; owl:onProperty include:condition_status ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:condition_data_source ; owl:allValuesFrom include:EnumConditionDataSource ] , [ a owl:Restriction ; owl:onProperty include:condition_data_source ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:hpo_label ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:hpo_label ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:hpo_code ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:hpo_code ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:mondo_label ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:mondo_label ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:mondo_code ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:mondo_code ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:maxo_label ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:maxo_label ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:maxo_code ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:maxo_code ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:other_label ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:other_label ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:other_code ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:other_code ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:measure_value ; owl:allValuesFrom xsd:float ] , [ a owl:Restriction ; owl:onProperty include:measure_value ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:measure_unit ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:measure_unit ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] . _:o161 xsd:minInclusive 0 . _:o162 xsd:maxInclusive 33000 . include:Biospecimen a owl:Class ; rdfs:label "Biospecimen" ; rdfs:comment "A Biospecimen Collected from A Participant" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty include:study_code ; owl:allValuesFrom include:Study ] , [ a owl:Restriction ; owl:onProperty include:study_code ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:allValuesFrom include:Participant ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sample_global_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:sample_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sample_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:sample_external_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sample_type ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:sample_type ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:age_at_biospecimen_collection ; owl:allValuesFrom xsd:integer ] , [ a owl:Restriction ; owl:onProperty include:age_at_biospecimen_collection ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:parent_sample_global_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:parent_sample_global_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:parent_sample_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:parent_sample_external_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:parent_sample_type ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:parent_sample_type ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:collection_global_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:collection_global_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:collection_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:collection_external_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:collection_sample_type ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:collection_sample_type ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:container_global_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:container_global_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:container_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:container_external_id ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:volume ; owl:allValuesFrom xsd:float ] , [ a owl:Restriction ; owl:onProperty include:volume ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:volume_unit ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:volume_unit ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:concentration ; owl:allValuesFrom xsd:float ] , [ a owl:Restriction ; owl:onProperty include:concentration ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:concentration_unit ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:concentration_unit ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:laboratory_procedure ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:laboratory_procedure ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:biospecimen_storage ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:biospecimen_storage ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sample_availability ; owl:allValuesFrom include:EnumAvailability ] , [ a owl:Restriction ; owl:onProperty include:sample_availability ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:container_availability ; owl:allValuesFrom include:EnumAvailability ] , [ a owl:Restriction ; owl:onProperty include:container_availability ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] . include:DataFile a owl:Class ; rdfs:label "Data File" ; rdfs:comment "Metadata about Data Files" ; rdfs:subClassOf [ a owl:Restriction ; owl:onProperty include:study_code ; owl:allValuesFrom include:Study ] , [ a owl:Restriction ; owl:onProperty include:study_code ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:allValuesFrom include:Participant ] , [ a owl:Restriction ; owl:onProperty include:participant_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:participant_external_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sample_global_id ; owl:allValuesFrom include:Biospecimen ] , [ a owl:Restriction ; owl:onProperty include:sample_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:sample_external_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:sample_external_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_name ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_name ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_global_id ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_global_id ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_upload_location ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_upload_location ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_s_3_location ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_s_3_location ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:drs_uri ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_hash ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_hash ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_access ; owl:allValuesFrom include:EnumDataAccess ] , [ a owl:Restriction ; owl:onProperty include:data_access ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_category ; owl:allValuesFrom include:EnumDataCategory ] , [ a owl:Restriction ; owl:onProperty include:data_category ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:data_type ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:data_type ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:experimental_strategy ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:experimental_platform ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_format ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_format ; owl:cardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_size ; owl:allValuesFrom xsd:integer ] , [ a owl:Restriction ; owl:onProperty include:file_size ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] , [ a owl:Restriction ; owl:onProperty include:file_size_unit ; owl:allValuesFrom xsd:string ] , [ a owl:Restriction ; owl:onProperty include:file_size_unit ; owl:maxCardinality "1"^^xsd:nonNegativeInteger ] . include:study_code a owl:ObjectProperty ; rdfs:label "Study Code" ; rdfs:comment "Unique identifier for the study (generally a short acronym)" ; rdfs:range include:EnumStudyCode . include:study_title a owl:DatatypeProperty ; rdfs:label "Study Title" ; rdfs:comment "Full title of the study" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:program a owl:ObjectProperty ; rdfs:label "Program" ; rdfs:comment "Funding source(s) for the study (pipe-separated if multiple)" ; rdfs:range include:EnumProgram . include:study_description a owl:DatatypeProperty ; rdfs:label "Study Description" ; rdfs:comment "Brief description of the study (2-4 sentences)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:principal_investigator_name a owl:DatatypeProperty ; rdfs:label "Principal Investigator Name" ; rdfs:comment "Name(s) of Principal Investigator(s) of this study; pipe-separated if multiple" ; rdfs:range xsd:string . include:study_contact_name a owl:DatatypeProperty ; rdfs:label "Study Contact Name" ; rdfs:comment "Name of contact person for this study; pipe-separated if multiple" ; rdfs:range xsd:string . include:study_contact_institution a owl:DatatypeProperty ; rdfs:label "Study Contact Institution" ; rdfs:comment "Institution of contact person for this study; pipe-separated if multiple" ; rdfs:range xsd:string . include:study_contact_email a owl:DatatypeProperty ; rdfs:label "Study Contact Email" ; rdfs:comment "Email address of contact person for this study; pipe-separated if multiple" ; rdfs:range xsd:string . include:vbr_email a owl:DatatypeProperty ; rdfs:label "VBR Email" ; rdfs:comment "Email address for Virtual Biorepository requests/inquiries, if participating" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:vbr_url a owl:ObjectProperty ; rdfs:label "VBR URL" ; rdfs:comment "Link to Virtual Biorepository request form, if participating" ; a owl:FunctionalProperty . include:vbr_readme a owl:DatatypeProperty ; rdfs:label "VBR Readme" ; rdfs:comment "Instructions for contacting or requesting samples from Virtual Biorepository, if participating" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:research_domain a owl:ObjectProperty ; rdfs:label "Research Domain" ; rdfs:comment "Main research domain(s) of the study, other than Down syndrome; pipe-separated if multiple" ; rdfs:range include:EnumResearchDomain . include:participant_lifespan_stage a owl:ObjectProperty ; rdfs:label "Participant Lifespan Stage" ; rdfs:comment "Focus age group(s) of the study population; pipe-separated if multiple" ; rdfs:range include:EnumParticipantLifespanStage . include:selection_criteria a owl:DatatypeProperty ; rdfs:label "Selection Criteria" ; rdfs:comment "Brief description of inclusion and/or exclusion criteria for the study" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:study_design a owl:ObjectProperty ; rdfs:label "Study Design" ; rdfs:comment "Overall design of study, including whether it is longitudinal and whether family members/unrelated controls are also enrolled" ; rdfs:range include:EnumStudyDesign . include:clinical_data_source_type a owl:ObjectProperty ; rdfs:label "Clinical Data Source Type" ; rdfs:comment "Source(s) of data collected from study participants; pipe-separated if multiple" ; rdfs:range include:EnumClinicalDataSourceType . include:study_website a owl:ObjectProperty ; rdfs:label "Study Website" ; rdfs:comment "Website for the study" ; a owl:FunctionalProperty . include:publication a owl:ObjectProperty ; rdfs:label "Publication" . include:expected_number_of_participants a owl:DatatypeProperty ; rdfs:label "Expected Number of Participants" ; rdfs:range xsd:integer ; a owl:FunctionalProperty . include:guid_type a owl:ObjectProperty ; rdfs:label "GUID Type" ; rdfs:comment "System used to generate globally unique identifiers (GUIDs)" ; rdfs:range include:EnumGuidType ; a owl:FunctionalProperty . include:guid_mapped a owl:DatatypeProperty ; rdfs:label "GUIDs Mapped?" ; rdfs:comment "For studies using NDAR GUIDs, have the GUIDs been added to the INCLUDE GUID Mapping File?" ; rdfs:range xsd:boolean ; a owl:FunctionalProperty . include:dbgap a owl:DatatypeProperty ; rdfs:label "dbGaP" ; rdfs:range xsd:string . include:acknowledgments a owl:DatatypeProperty ; rdfs:label "Acknowledgments" ; rdfs:comment "Funding statement and acknowledgments for this study" ; rdfs:range xsd:string . include:citation_statement a owl:DatatypeProperty ; rdfs:label "Citation Statement" ; rdfs:comment "Statement that secondary data users should use to acknowledge use of this dataset. E.g., \"The results analyzed and here are based in whole or in part upon data generated by the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project , and were accessed from the INCLUDE Data Hub and .\"" ; rdfs:range xsd:string . include:doi a owl:ObjectProperty ; rdfs:label "DOI" ; rdfs:comment "Unique Digital Object Identifier for each Study and Dataset, minted by the DCC using DataCite" ; a owl:FunctionalProperty . include:doi_citation a owl:DatatypeProperty ; rdfs:label "DOI Citation" ; rdfs:comment "Bibliographic citation for DOI, generated by DataCite" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:dataset_name a owl:DatatypeProperty ; rdfs:label "Dataset Name" ; rdfs:comment "Full name of the dataset, provided by contributor" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:dataset_description a owl:DatatypeProperty ; rdfs:label "Dataset Description" ; rdfs:comment "Brief additional notes about the dataset (1-3 sentences) that are not already captured in the other fields" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:dataset_global_id a owl:ObjectProperty ; rdfs:label "Dataset Global ID" ; rdfs:comment "Unique Global ID for dataset, generated by DCC" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:dataset_external_id a owl:DatatypeProperty ; rdfs:label "Dataset External ID" ; rdfs:comment "Unique identifier or code for dataset, if provided by contributor" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:expected_number_of_files a owl:DatatypeProperty ; rdfs:label "Expected Number of Files" ; rdfs:comment "Expected number of files associated with this dataset, including dictionaries. If additional explanation is needed, please add to Dataset Description field." ; rdfs:range xsd:integer ; a owl:FunctionalProperty . include:data_collection_start_year a owl:DatatypeProperty ; rdfs:label "Data Collection Start Year" ; rdfs:comment "Year that data collection started" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:data_collection_end_year a owl:DatatypeProperty ; rdfs:label "Data Collection End Year" ; rdfs:comment "Year that data collection ended" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:access_limitations a owl:DatatypeProperty ; rdfs:label "Access Limitations" ; rdfs:comment "Data access limitations, as defined in the GA4GH Data Use Ontology (DUO; can list more than one, pipe separated)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:access_requirements a owl:DatatypeProperty ; rdfs:label "Access Requirements" ; rdfs:comment "Data access requirements, as defined in the GA4GH Data Use Ontology (DUO; can list more than one, pipe separated)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:other_repository a owl:ObjectProperty ; rdfs:label "Other Repository" ; rdfs:comment "URL if dataset is already deposited in a public repository other than dbGaP (e.g. LONI, Metabolomics Workbench, etc.)" ; a owl:FunctionalProperty . include:other_access_authority a owl:DatatypeProperty ; rdfs:label "Other Access Authority" ; rdfs:comment "Email or URL for dataset's Access Authority, if not dbGaP" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:is_harmonized a owl:DatatypeProperty ; rdfs:label "Is Harmonized" ; rdfs:comment "All of the elements in this Dataset are harmonized and available in the INCLUDE Data Hub" ; rdfs:range xsd:boolean ; a owl:FunctionalProperty . include:dataset_manifest_location a owl:DatatypeProperty ; rdfs:label "Dataset Manifest Location" ; rdfs:comment "Location of associated Dataset Manifest" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:participant_global_id a owl:ObjectProperty ; rdfs:label "Participant Global ID" ; rdfs:comment "Unique INCLUDE global identifier for the participant, assigned by DCC" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:participant_external_id a owl:DatatypeProperty ; rdfs:label "Participant External ID" ; rdfs:comment "Unique, de-identified identifier for the participant, assigned by data contributor. External IDs must be two steps removed from personal information in the study records." ; rdfs:range xsd:string . include:family_id a owl:DatatypeProperty ; rdfs:label "Family ID" ; rdfs:comment "Unique identifer for family to which Participant belongs, assigned by data contributor" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:family_type a owl:ObjectProperty ; rdfs:label "Family Type" ; rdfs:comment "Structure of family members participating in the study" ; rdfs:range include:EnumFamilyType ; a owl:FunctionalProperty . include:father_id a owl:DatatypeProperty ; rdfs:label "Father ID" ; rdfs:comment "Participant External ID for Participant's father (NA if Participant is not the proband)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:mother_id a owl:DatatypeProperty ; rdfs:label "Mother ID" ; rdfs:comment "Participant External ID for Participant's mother (NA if Participant is not the proband)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:sibling_id a owl:DatatypeProperty ; rdfs:label "Sibling ID" ; rdfs:comment "Participant External ID for Participant's sibling(s) (NA if Participant is not the proband)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:other_family_member_id a owl:DatatypeProperty ; rdfs:label "Other Family Member ID" ; rdfs:comment "Participant External ID for Participant's other family members (NA if Participant is not the proband)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:family_relationship a owl:ObjectProperty ; rdfs:label "Family Relationship" ; rdfs:comment "Relationship of Participant to proband" ; rdfs:range include:EnumFamilyRelationship ; a owl:FunctionalProperty . include:sex a owl:ObjectProperty ; rdfs:label "Sex" ; rdfs:comment "Sex of Participant" ; rdfs:range include:EnumSex ; a owl:FunctionalProperty . include:race a owl:ObjectProperty ; rdfs:label "Race" ; rdfs:comment "Race of Participant" ; rdfs:range include:EnumRace ; a owl:FunctionalProperty . include:ethnicity a owl:ObjectProperty ; rdfs:label "Ethnicity" ; rdfs:comment "Ethnicity of Participant" ; rdfs:range include:EnumEthnicity ; a owl:FunctionalProperty . include:down_syndrome_status a owl:ObjectProperty ; rdfs:label "Down Syndrome Status" ; rdfs:comment "Down Syndrome status of participant" ; rdfs:range include:EnumDownSyndromeStatus ; a owl:FunctionalProperty . include:age_at_first_participant_engagement a owl:DatatypeProperty ; rdfs:label "Age at First Participant Engagement" ; rdfs:comment "Age in days of Participant at first recorded study event (enrollment, visit, observation, sample collection, survey completion, etc.). Age at enrollment is preferred, if available." ; rdfs:range [ a rdfs:Datatype ; owl:onDatatype xsd:integer ; owl:withRestrictions ( _:o272 _:o273 ) ] ; a owl:FunctionalProperty . _:o272 xsd:minInclusive 0 . _:o273 xsd:maxInclusive 33000 . include:first_participant_engagement_event a owl:DatatypeProperty ; rdfs:label "First Participant Engagement Event" ; rdfs:comment "Event for which Age at First Participant Engagement is given (e.g. enrollment, visit, observation, sample collection, survey completion, etc.). Age at enrollment is preferred, if available." ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:outcomes_vital_status a owl:ObjectProperty ; rdfs:label "Outcomes Vital Status" ; rdfs:comment "Whether participant is alive or dead" ; rdfs:range include:EnumVitalStatus ; a owl:FunctionalProperty . include:age_at_last_vital_status a owl:DatatypeProperty ; rdfs:label "Age at Last Vital Status" ; rdfs:comment "Age in days when participant's vital status was last recorded" ; rdfs:range [ a rdfs:Datatype ; owl:onDatatype xsd:integer ; owl:withRestrictions ( _:o275 _:o276 ) ] ; a owl:FunctionalProperty . _:o275 xsd:minInclusive 0 . _:o276 xsd:maxInclusive 33000 . include:event_id a owl:DatatypeProperty ; rdfs:label "Event ID" ; rdfs:comment "Identifier for event (Visit, Survey completion, Sample collection, etc.) to which the Condition data are linked, if applicable. There may be multiple events linked to a Participant." ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:event_type a owl:DatatypeProperty ; rdfs:label "Event Type" ; rdfs:comment "Type of event for which Event ID is given (Visit, Survey completion, Sample collection, etc.)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:condition_measure_source_text a owl:DatatypeProperty ; rdfs:label "Condition or Measure Source Text" ; rdfs:comment "Co-occurring Condition (phenotype or diagnosis) or Measure (observation with numeric value), as described by data contributor. The Down Syndrome Genetic Diagnosis will be rolled into this field." ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:age_at_condition_measure_observation a owl:DatatypeProperty ; rdfs:label "Age At Condition or Measure Observation" ; rdfs:comment "Age in days at which Condition or Measure was observed, recorded, or diagnosed" ; rdfs:range [ a rdfs:Datatype ; owl:onDatatype xsd:integer ; owl:withRestrictions ( _:o278 _:o279 ) ] ; a owl:FunctionalProperty . _:o278 xsd:minInclusive 0 . _:o279 xsd:maxInclusive 33000 . include:condition_interpretation a owl:ObjectProperty ; rdfs:label "Condition Interpretation" ; rdfs:comment "Whether Condition was observed or not" ; rdfs:range include:EnumConditionInterpretation ; a owl:FunctionalProperty . include:condition_status a owl:ObjectProperty ; rdfs:label "Condition Status" ; rdfs:comment "Whether the Condition is ongoing, has been resolved, or this is a general history of the condition without known dates" ; rdfs:range include:EnumConditionStatus ; a owl:FunctionalProperty . include:condition_data_source a owl:ObjectProperty ; rdfs:label "Condition Data Source" ; rdfs:comment "Whether Condition information was obtained by the investigator or reported by participant/family member" ; rdfs:range include:EnumConditionDataSource ; a owl:FunctionalProperty . include:hpo_label a owl:DatatypeProperty ; rdfs:label "HPO Label" ; rdfs:comment "Label for Condition in the Human Phenotype Ontology (HPO)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:hpo_code a owl:DatatypeProperty ; rdfs:label "HPO Code" ; rdfs:comment "Code for Condition in the Human Phenotype Ontology (HPO)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:mondo_label a owl:DatatypeProperty ; rdfs:label "MONDO Label" ; rdfs:comment "Label for Condition in the Mondo Disease Ontology (MONDO)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:mondo_code a owl:DatatypeProperty ; rdfs:label "MONDO Code" ; rdfs:comment "Code for Condition in the Mondo Disease Ontology (Mondo)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:maxo_label a owl:DatatypeProperty ; rdfs:label "MAXO Label" ; rdfs:comment "Label for Condition in the Medical Action Ontology (MAXO)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:maxo_code a owl:DatatypeProperty ; rdfs:label "MAXO Code" ; rdfs:comment "Code for condition in the Medical Action Ontology (MAXO)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:other_label a owl:DatatypeProperty ; rdfs:label "Other Label" ; rdfs:comment "Label for Condition in another ontology (if no match in HPO, MONDO, or MAXO)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:other_code a owl:DatatypeProperty ; rdfs:label "Other Code" ; rdfs:comment "Code for Condition in another ontology (if no match in HPO, MONDO, or MAXO)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:measure_value a owl:DatatypeProperty ; rdfs:label "Measure Value" ; rdfs:comment "Numeric value of Measure" ; rdfs:range xsd:float ; a owl:FunctionalProperty . include:measure_unit a owl:DatatypeProperty ; rdfs:label "Measure Unit" ; rdfs:comment "Unit that is associated with Measure Value (e.g. kg, cm, %, x10^9/L, etc.)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:sample_global_id a owl:ObjectProperty ; rdfs:label "Sample Global ID" ; rdfs:comment "INCLUDE global identifier for sample, assigned by DCC" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:sample_external_id a owl:DatatypeProperty ; rdfs:label "Sample External ID" ; rdfs:comment "Unique identifier for sample, assigned by data contributor. A sample is a unique biological material; two samples with two different IDs are biologically distinct." ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:sample_type a owl:DatatypeProperty ; rdfs:label "Sample Type" ; rdfs:comment "Type of biological material comprising the Sample (e.g. Plasma, White blood cells, Red blood cells, DNA, RNA, Peripheral blood mononuclear cells, CD4+ Tconv cells, NK cells, Monocytes, CD8+ T cells, B cells, Granulocytes, Treg cells)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:age_at_biospecimen_collection a owl:DatatypeProperty ; rdfs:label "Age At Biospecimen Collection" ; rdfs:comment "Age in days of participant at time of biospecimen collection" ; rdfs:range xsd:integer ; a owl:FunctionalProperty . include:parent_sample_global_id a owl:DatatypeProperty ; rdfs:label "Parent Sample Global ID" ; rdfs:comment "INCLUDE global identifier for the direct parent from which Sample was derived, assigned by DCC" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:parent_sample_external_id a owl:DatatypeProperty ; rdfs:label "Parent Sample External ID" ; rdfs:comment "Identifier for the direct parent from which Sample was derived, processed, pooled, etc. (if applicable); assigned by data contributor" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:parent_sample_type a owl:DatatypeProperty ; rdfs:label "Parent Sample Type" ; rdfs:comment "Type of biological material comprising the Parent Sample (e.g. Peripheral Whole Blood, Derived Cell Line, Saliva, Whole blood, WBCs)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:collection_global_id a owl:DatatypeProperty ; rdfs:label "Collection Global ID" ; rdfs:comment "INCLUDE global identifier for the eldest sample in a lineage, assigned by DCC" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:collection_external_id a owl:DatatypeProperty ; rdfs:label "Collection External ID" ; rdfs:comment "Identifier for the eldest sample in a lineage of processed, pooled, or aliquoted samples - typically the material actually collected from the Participant. This may be the same as Parent Sample ID or Sample ID (if no processing was performed). Assigned by data contributor." ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:collection_sample_type a owl:DatatypeProperty ; rdfs:label "Collection Sample Type" ; rdfs:comment "Type of biological material comprising the Collected Sample (e.g. Whole blood, Not reported, Saliva, Derived cell line)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:container_global_id a owl:DatatypeProperty ; rdfs:label "Container Global ID" ; rdfs:comment "INCLUDE global identifier for specific container/aliquot of sample, assigned by DCC" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:container_external_id a owl:DatatypeProperty ; rdfs:label "Container External ID" ; rdfs:comment "Identifier for specific container/aliquot of sample, assigned by data contributor. For example, distinct aliquots of a sample will have the same Sample ID but different Container IDs." ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:volume a owl:DatatypeProperty ; rdfs:label "Volume" ; rdfs:comment "Amount of sample in container" ; rdfs:range xsd:float ; a owl:FunctionalProperty . include:volume_unit a owl:DatatypeProperty ; rdfs:label "Volume Unit" ; rdfs:comment "Unit of sample volume" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:concentration a owl:DatatypeProperty ; rdfs:label "Concentration" ; rdfs:comment "Concentration of sample in container" ; rdfs:range xsd:float ; a owl:FunctionalProperty . include:concentration_unit a owl:DatatypeProperty ; rdfs:label "Concentration Unit" ; rdfs:comment "Unit of sample concentration" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:laboratory_procedure a owl:DatatypeProperty ; rdfs:label "Laboratory Procedure" ; rdfs:comment "Procedure by which Sample was derived from Parent Sample (e.g. Centrifugation, RBC lysis, Lyse/fix buffer, FACS, PAXgene DNA, PAXgene RNA, Qiagen Allprep, Ficoll)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:biospecimen_storage a owl:DatatypeProperty ; rdfs:label "Biospecimen Storage" ; rdfs:comment "Method by which Container is stored (e.g. Minus 80 degrees Celsius, Liquid nitrogen storage)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:sample_availability a owl:ObjectProperty ; rdfs:label "Sample Availability" ; rdfs:comment "Whether or not the Sample (any Container thereof) is potentially available for sharing through the Virtual Biorepository" ; rdfs:range include:EnumAvailability ; a owl:FunctionalProperty . include:container_availability a owl:ObjectProperty ; rdfs:label "Container Availability" ; rdfs:comment "Whether or not the specific Container is potentially available for sharing through the Virtual Biorepository" ; rdfs:range include:EnumAvailability ; a owl:FunctionalProperty . include:file_name a owl:DatatypeProperty ; rdfs:label "File Name" ; rdfs:comment "Name of file, assigned by data contributor" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:file_global_id a owl:ObjectProperty ; rdfs:label "File Global ID" ; rdfs:comment "INCLUDE global file identifier, assigned by DCC" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:file_upload_location a owl:DatatypeProperty ; rdfs:label "File Upload Location" ; rdfs:comment "Where source file was uploaded, if not directly to an S3 bucket (e.g. Synapse)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:file_s_3_location a owl:DatatypeProperty ; rdfs:label "File S3 Location" ; rdfs:comment "S3 bucket location of file; also serves as dewrangle descriptor" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:drs_uri a owl:ObjectProperty ; rdfs:label "DRS URI" ; rdfs:comment "Data Repository Services API Uniform Resource Identifier" ; a owl:FunctionalProperty . include:file_hash a owl:DatatypeProperty ; rdfs:label "File Hash" ; rdfs:comment "md5 hash of this file for validation (if known)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:data_access a owl:ObjectProperty ; rdfs:label "Data Access" ; rdfs:comment "Type of access control on this file, determined by DCC" ; rdfs:range include:EnumDataAccess ; a owl:FunctionalProperty . include:data_category a owl:ObjectProperty ; rdfs:label "Data Category" ; rdfs:range include:EnumDataCategory . include:data_type a owl:DatatypeProperty ; rdfs:label "Data Type" ; rdfs:range xsd:string . include:experimental_strategy a owl:DatatypeProperty ; rdfs:label "Experimental Strategy" ; rdfs:range xsd:string . include:experimental_platform a owl:DatatypeProperty ; rdfs:label "Experimental Platform" ; rdfs:comment "Specific platform used to perform experiment; pipe-separated if multiple (e.g. SOMAscan, MSD, Luminex, Illumina)" ; rdfs:range xsd:string . include:file_format a owl:DatatypeProperty ; rdfs:label "File Format" ; rdfs:comment "Format of file (e.g. tsv, cram, gvcf, vcf, maf, txt, pdf, html, png)" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:file_size a owl:DatatypeProperty ; rdfs:label "File Size" ; rdfs:comment "Size of file, if known (mainly important if large)" ; rdfs:range xsd:integer ; a owl:FunctionalProperty . include:file_size_unit a owl:DatatypeProperty ; rdfs:label "File Size Unit" ; rdfs:comment "Unit of file size" ; rdfs:range xsd:string ; a owl:FunctionalProperty . include:EnumProgram a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumProgram.INCLUDE include:EnumProgram.KF include:EnumProgram.OTHER ) ] . include:EnumProgram.INCLUDE a owl:NamedIndividual ; skos:notation "include" ; rdfs:label "INCLUDE" ; a include:EnumProgram . include:EnumProgram.KF a owl:NamedIndividual ; skos:notation "kf" ; rdfs:label "KF" ; a include:EnumProgram . include:EnumProgram.OTHER a owl:NamedIndividual ; skos:notation "other" ; rdfs:label "Other" ; a include:EnumProgram . include:EnumStudyCode a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumStudyCode.AADSC include:EnumStudyCode.ABC_DS include:EnumStudyCode.ADS include:EnumStudyCode.AECOM_DS include:EnumStudyCode.BEST_21 include:EnumStudyCode.BRAINPOWER include:EnumStudyCode.BRI_DSR include:EnumStudyCode.CCDS include:EnumStudyCode.CHILD_DS include:EnumStudyCode.CHARGE_DS include:EnumStudyCode.DECIDAS include:EnumStudyCode.DS_ARC include:EnumStudyCode.DS_BRAIN include:EnumStudyCode.DS_COG_ALL include:EnumStudyCode.DS_COG_AML include:EnumStudyCode.DS_DETERMINED include:EnumStudyCode.DS_HOME include:EnumStudyCode.DS_HSAT include:EnumStudyCode.DS_ISP include:EnumStudyCode.DS_NEXUS include:EnumStudyCode.DS_PALS include:EnumStudyCode.DS_PCGC include:EnumStudyCode.DS_SLEEP include:EnumStudyCode.DS_VITE include:EnumStudyCode.DS_360_CHD include:EnumStudyCode.DSC include:EnumStudyCode.DSPOSTBFMULTI include:EnumStudyCode.DSRRS include:EnumStudyCode.ECODS include:EnumStudyCode.EXCEEDS include:EnumStudyCode.HTP include:EnumStudyCode.IBIS_DS include:EnumStudyCode.JAKI_DS include:EnumStudyCode.OPTIMAL include:EnumStudyCode.TEAM_DS include:EnumStudyCode.TOMI include:EnumStudyCode.TRC_DS include:EnumStudyCode.X_01_DESMITH include:EnumStudyCode.X_01_HAKONARSON ) ] . include:EnumStudyCode.AADSC a owl:NamedIndividual ; skos:notation "aadsc" ; rdfs:label "AADSC" ; a include:EnumStudyCode . include:EnumStudyCode.ABC_DS a owl:NamedIndividual ; skos:notation "abc_ds" ; rdfs:label "ABC-DS" ; a include:EnumStudyCode . include:EnumStudyCode.ADS a owl:NamedIndividual ; skos:notation "ads" ; rdfs:label "ADS" ; a include:EnumStudyCode . include:EnumStudyCode.AECOM_DS a owl:NamedIndividual ; skos:notation "aecom_ds" ; rdfs:label "AECOM-DS" ; a include:EnumStudyCode . include:EnumStudyCode.BEST_21 a owl:NamedIndividual ; skos:notation "best21" ; rdfs:label "BEST21" ; a include:EnumStudyCode . include:EnumStudyCode.BRAINPOWER a owl:NamedIndividual ; skos:notation "brainpower" ; rdfs:label "BrainPower" ; a include:EnumStudyCode . include:EnumStudyCode.BRI_DSR a owl:NamedIndividual ; skos:notation "bri_dsr" ; rdfs:label "BRI-DSR" ; a include:EnumStudyCode . include:EnumStudyCode.CCDS a owl:NamedIndividual ; skos:notation "ccds" ; rdfs:label "CCDS" ; a include:EnumStudyCode . include:EnumStudyCode.CHILD_DS a owl:NamedIndividual ; skos:notation "child_ds" ; rdfs:label "CHILD-DS" ; a include:EnumStudyCode . include:EnumStudyCode.CHARGE_DS a owl:NamedIndividual ; skos:notation "charge_ds" ; rdfs:label "CHARGE-DS" ; a include:EnumStudyCode . include:EnumStudyCode.DECIDAS a owl:NamedIndividual ; skos:notation "decidas" ; rdfs:label "DECIDAS" ; a include:EnumStudyCode . include:EnumStudyCode.DS_ARC a owl:NamedIndividual ; skos:notation "ds_arc" ; rdfs:label "DS-ARC" ; a include:EnumStudyCode . include:EnumStudyCode.DS_BRAIN a owl:NamedIndividual ; skos:notation "ds_brain" ; rdfs:label "DS-Brain" ; a include:EnumStudyCode . include:EnumStudyCode.DS_COG_ALL a owl:NamedIndividual ; skos:notation "ds_cog_all" ; rdfs:label "DS-COG-ALL" ; a include:EnumStudyCode . include:EnumStudyCode.DS_COG_AML a owl:NamedIndividual ; skos:notation "ds_cog_aml" ; rdfs:label "DS-COG-AML" ; a include:EnumStudyCode . include:EnumStudyCode.DS_DETERMINED a owl:NamedIndividual ; skos:notation "ds_determined" ; rdfs:label "DS-DETERMINED" ; a include:EnumStudyCode . include:EnumStudyCode.DS_HOME a owl:NamedIndividual ; skos:notation "ds_home" ; rdfs:label "DS-HOME" ; a include:EnumStudyCode . include:EnumStudyCode.DS_HSAT a owl:NamedIndividual ; skos:notation "ds_hsat" ; rdfs:label "DS-HSAT" ; a include:EnumStudyCode . include:EnumStudyCode.DS_ISP a owl:NamedIndividual ; skos:notation "ds_isp" ; rdfs:label "DS-ISP" ; a include:EnumStudyCode . include:EnumStudyCode.DS_NEXUS a owl:NamedIndividual ; skos:notation "ds_nexus" ; rdfs:label "DS-Nexus" ; a include:EnumStudyCode . include:EnumStudyCode.DS_PALS a owl:NamedIndividual ; skos:notation "ds_pals" ; rdfs:label "DS-PALS" ; a include:EnumStudyCode . include:EnumStudyCode.DS_PCGC a owl:NamedIndividual ; skos:notation "ds_pcgc" ; rdfs:label "DS-PCGC" ; a include:EnumStudyCode . include:EnumStudyCode.DS_SLEEP a owl:NamedIndividual ; skos:notation "ds_sleep" ; rdfs:label "DS-Sleep" ; a include:EnumStudyCode . include:EnumStudyCode.DS_VITE a owl:NamedIndividual ; skos:notation "ds_vite" ; rdfs:label "DS-VitE" ; a include:EnumStudyCode . include:EnumStudyCode.DS_360_CHD a owl:NamedIndividual ; skos:notation "ds360_chd" ; rdfs:label "DS360-CHD" ; a include:EnumStudyCode . include:EnumStudyCode.DSC a owl:NamedIndividual ; skos:notation "dsc" ; rdfs:label "DSC" ; a include:EnumStudyCode . include:EnumStudyCode.DSPOSTBFMULTI a owl:NamedIndividual ; skos:notation "dspostbfmulti" ; rdfs:label "DSpostBFmulti" ; a include:EnumStudyCode . include:EnumStudyCode.DSRRS a owl:NamedIndividual ; skos:notation "dsrrs" ; rdfs:label "DSRRS" ; a include:EnumStudyCode . include:EnumStudyCode.ECODS a owl:NamedIndividual ; skos:notation "ecods" ; rdfs:label "ECODS" ; a include:EnumStudyCode . include:EnumStudyCode.EXCEEDS a owl:NamedIndividual ; skos:notation "exceeds" ; rdfs:label "EXcEEDS" ; a include:EnumStudyCode . include:EnumStudyCode.HTP a owl:NamedIndividual ; skos:notation "htp" ; rdfs:label "HTP" ; a include:EnumStudyCode . include:EnumStudyCode.IBIS_DS a owl:NamedIndividual ; skos:notation "ibis-ds" ; rdfs:label "IBIS-DS" ; a include:EnumStudyCode . include:EnumStudyCode.JAKI_DS a owl:NamedIndividual ; skos:notation "jaki_ds" ; rdfs:label "JAKi-DS" ; a include:EnumStudyCode . include:EnumStudyCode.OPTIMAL a owl:NamedIndividual ; skos:notation "optimal" ; rdfs:label "OPTimal" ; a include:EnumStudyCode . include:EnumStudyCode.TEAM_DS a owl:NamedIndividual ; skos:notation "team_ds" ; rdfs:label "TEAM-DS" ; a include:EnumStudyCode . include:EnumStudyCode.TOMI a owl:NamedIndividual ; skos:notation "tomi" ; rdfs:label "TOMI" ; a include:EnumStudyCode . include:EnumStudyCode.TRC_DS a owl:NamedIndividual ; skos:notation "trc_ds" ; rdfs:label "TRC-DS" ; a include:EnumStudyCode . include:EnumStudyCode.X_01_DESMITH a owl:NamedIndividual ; skos:notation "x01_desmith" ; rdfs:label "X01-deSmith" ; a include:EnumStudyCode . include:EnumStudyCode.X_01_HAKONARSON a owl:NamedIndividual ; skos:notation "x01_hakonarson" ; rdfs:label "X01-Hakonarson" ; a include:EnumStudyCode . include:EnumResearchDomain a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( mesh:D001520 mesh:D006330 mesh:D007154 mesh:D006402 include:EnumResearchDomain.NEURODEVELOPMENT mesh:D012893 mesh:D013568 mesh:D010809 include:EnumResearchDomain.OTHER ) ] . mesh:D001520 a owl:NamedIndividual ; skos:notation "behavior_and_behavior_mechanisms" ; rdfs:label "Behavior and Behavior Mechanisms" ; a include:EnumResearchDomain . mesh:D006330 a owl:NamedIndividual ; skos:notation "congenital_heart_defects" ; rdfs:label "Congenital Heart Defects" ; a include:EnumResearchDomain . mesh:D007154 a owl:NamedIndividual ; skos:notation "immune_system_diseases" ; rdfs:label "Immune System Diseases" ; a include:EnumResearchDomain . mesh:D006402 a owl:NamedIndividual ; skos:notation "hematologic_diseases" ; rdfs:label "Hematologic Diseases" ; a include:EnumResearchDomain . include:EnumResearchDomain.NEURODEVELOPMENT a owl:NamedIndividual ; skos:notation "neurodevelopment" ; rdfs:label "Neurodevelopment" ; a include:EnumResearchDomain . mesh:D012893 a owl:NamedIndividual ; skos:notation "sleep_wake_disorders" ; rdfs:label "Sleep Wake Disorders" ; a include:EnumResearchDomain . mesh:D013568 a owl:NamedIndividual ; skos:notation "all_co_occurring_conditions" ; rdfs:label "All Co-occurring Conditions" ; a include:EnumResearchDomain . mesh:D010809 a owl:NamedIndividual ; skos:notation "physical_fitness" ; rdfs:label "Physical Fitness" ; a include:EnumResearchDomain . include:EnumResearchDomain.OTHER a owl:NamedIndividual ; skos:notation "other" ; rdfs:label "Other" ; a include:EnumResearchDomain . include:EnumParticipantLifespanStage a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumParticipantLifespanStage.FETAL include:EnumParticipantLifespanStage.NEONATAL include:EnumParticipantLifespanStage.PEDIATRIC include:EnumParticipantLifespanStage.ADULT ) ] . include:EnumParticipantLifespanStage.FETAL a owl:NamedIndividual ; skos:notation "fetal" ; rdfs:label "Fetal" ; a include:EnumParticipantLifespanStage . include:EnumParticipantLifespanStage.NEONATAL a owl:NamedIndividual ; skos:notation "neonatal" ; rdfs:label "Neonatal" ; rdfs:comment "0-28 days old" ; a include:EnumParticipantLifespanStage . include:EnumParticipantLifespanStage.PEDIATRIC a owl:NamedIndividual ; skos:notation "pediatric" ; rdfs:label "Pediatric" ; rdfs:comment "Birth-17 years old" ; a include:EnumParticipantLifespanStage . include:EnumParticipantLifespanStage.ADULT a owl:NamedIndividual ; skos:notation "adult" ; rdfs:label "Adult" ; rdfs:comment "18+ years old" ; a include:EnumParticipantLifespanStage . include:EnumStudyDesign a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumStudyDesign.CASE_CONTROL include:EnumStudyDesign.CASE_SET include:EnumStudyDesign.CONTROL_SET include:EnumStudyDesign.CLINICAL_TRIAL include:EnumStudyDesign.CROSS_SECTIONAL include:EnumStudyDesign.FAMILY_TWINS_TRIOS include:EnumStudyDesign.INTERVENTIONAL include:EnumStudyDesign.LONGITUDINAL include:EnumStudyDesign.TUMOR_VS_MATCHED_NORMAL ) ] . include:EnumStudyDesign.CASE_CONTROL a owl:NamedIndividual ; skos:notation "case_control" ; rdfs:label "Case-Control" ; a include:EnumStudyDesign . include:EnumStudyDesign.CASE_SET a owl:NamedIndividual ; skos:notation "case_set" ; rdfs:label "Case Set" ; a include:EnumStudyDesign . include:EnumStudyDesign.CONTROL_SET a owl:NamedIndividual ; skos:notation "control_set" ; rdfs:label "Control Set" ; a include:EnumStudyDesign . include:EnumStudyDesign.CLINICAL_TRIAL a owl:NamedIndividual ; skos:notation "clinical_trial" ; rdfs:label "Clinical Trial" ; a include:EnumStudyDesign . include:EnumStudyDesign.CROSS_SECTIONAL a owl:NamedIndividual ; skos:notation "cross_sectional" ; rdfs:label "Cross-Sectional" ; a include:EnumStudyDesign . include:EnumStudyDesign.FAMILY_TWINS_TRIOS a owl:NamedIndividual ; skos:notation "family_twins_trios" ; rdfs:label "Family/Twins/Trios" ; a include:EnumStudyDesign . include:EnumStudyDesign.INTERVENTIONAL a owl:NamedIndividual ; skos:notation "interventional" ; rdfs:label "Interventional" ; a include:EnumStudyDesign . include:EnumStudyDesign.LONGITUDINAL a owl:NamedIndividual ; skos:notation "longitudinal" ; rdfs:label "Longitudinal" ; a include:EnumStudyDesign . include:EnumStudyDesign.TUMOR_VS_MATCHED_NORMAL a owl:NamedIndividual ; skos:notation "tumor_vs_matched_normal" ; rdfs:label "Tumor vs Matched Normal" ; a include:EnumStudyDesign . include:EnumClinicalDataSourceType a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumClinicalDataSourceType.MEDICAL_RECORD include:EnumClinicalDataSourceType.INVESTIGATOR_ASSESSMENT include:EnumClinicalDataSourceType.PARTICIPANT_OR_CAREGIVER_REPORT include:EnumClinicalDataSourceType.OTHER include:EnumClinicalDataSourceType.UNKNOWN ) ] . include:EnumClinicalDataSourceType.MEDICAL_RECORD a owl:NamedIndividual ; skos:notation "medical_record" ; rdfs:label "Medical Record" ; rdfs:comment "Data obtained directly from medical record" ; a include:EnumClinicalDataSourceType . include:EnumClinicalDataSourceType.INVESTIGATOR_ASSESSMENT a owl:NamedIndividual ; skos:notation "investigator_assessment" ; rdfs:label "Investigator Assessment" ; rdfs:comment "Data obtained by examination, interview, etc. with investigator" ; a include:EnumClinicalDataSourceType . include:EnumClinicalDataSourceType.PARTICIPANT_OR_CAREGIVER_REPORT a owl:NamedIndividual ; skos:notation "participant_or_caregiver_report" ; rdfs:label "Participant or Caregiver Report" ; rdfs:comment "Data obtained from survey, questionnaire, etc. filled out by participant or caregiver" ; a include:EnumClinicalDataSourceType . include:EnumClinicalDataSourceType.OTHER a owl:NamedIndividual ; skos:notation "other" ; rdfs:label "Other" ; rdfs:comment "Data obtained from other source, such as tissue bank" ; a include:EnumClinicalDataSourceType . include:EnumClinicalDataSourceType.UNKNOWN a owl:NamedIndividual ; skos:notation "unknown" ; rdfs:label "Unknown" ; a include:EnumClinicalDataSourceType . include:EnumDataCategory a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumDataCategory.UNHARMONIZED_DEMOGRAPHIC_CLINICAL_DATA include:EnumDataCategory.HARMONIZED_DEMOGRAPHIC_CLINICAL_DATA include:EnumDataCategory.GENOMICS include:EnumDataCategory.TRANSCRIPTOMICS include:EnumDataCategory.EPIGENOMICS include:EnumDataCategory.PROTEOMICS include:EnumDataCategory.METABOLOMICS include:EnumDataCategory.COGNITIVE_BEHAVIORAL include:EnumDataCategory.IMMUNE_PROFILING include:EnumDataCategory.IMAGING include:EnumDataCategory.MICROBIOME include:EnumDataCategory.FITNESS include:EnumDataCategory.PHYSICAL_ACTIVITY include:EnumDataCategory.OTHER include:EnumDataCategory.SLEEP_STUDY ) ] . include:EnumDataCategory.UNHARMONIZED_DEMOGRAPHIC_CLINICAL_DATA a owl:NamedIndividual ; skos:notation "unharmonized_demographic_clinical_data" ; rdfs:label "Unharmonized Demographic/Clinical Data" ; a include:EnumDataCategory . include:EnumDataCategory.HARMONIZED_DEMOGRAPHIC_CLINICAL_DATA a owl:NamedIndividual ; skos:notation "harmonized_demographic_clinical_data" ; rdfs:label "Harmonized Demographic/Clinical Data" ; a include:EnumDataCategory . include:EnumDataCategory.GENOMICS a owl:NamedIndividual ; skos:notation "genomics" ; rdfs:label "Genomics" ; a include:EnumDataCategory . include:EnumDataCategory.TRANSCRIPTOMICS a owl:NamedIndividual ; skos:notation "transcriptomics" ; rdfs:label "Transcriptomics" ; a include:EnumDataCategory . include:EnumDataCategory.EPIGENOMICS a owl:NamedIndividual ; skos:notation "epigenomics" ; rdfs:label "Epigenomics" ; a include:EnumDataCategory . include:EnumDataCategory.PROTEOMICS a owl:NamedIndividual ; skos:notation "proteomics" ; rdfs:label "Proteomics" ; a include:EnumDataCategory . include:EnumDataCategory.METABOLOMICS a owl:NamedIndividual ; skos:notation "metabolomics" ; rdfs:label "Metabolomics" ; a include:EnumDataCategory . include:EnumDataCategory.COGNITIVE_BEHAVIORAL a owl:NamedIndividual ; skos:notation "cognitive_behavioral" ; rdfs:label "Cognitive/Behavioral" ; a include:EnumDataCategory . include:EnumDataCategory.IMMUNE_PROFILING a owl:NamedIndividual ; skos:notation "immune_profiling" ; rdfs:label "Immune Profiling" ; a include:EnumDataCategory . include:EnumDataCategory.IMAGING a owl:NamedIndividual ; skos:notation "imaging" ; rdfs:label "Imaging" ; a include:EnumDataCategory . include:EnumDataCategory.MICROBIOME a owl:NamedIndividual ; skos:notation "microbiome" ; rdfs:label "Microbiome" ; a include:EnumDataCategory . include:EnumDataCategory.FITNESS a owl:NamedIndividual ; skos:notation "fitness" ; rdfs:label "Fitness" ; a include:EnumDataCategory . include:EnumDataCategory.PHYSICAL_ACTIVITY a owl:NamedIndividual ; skos:notation "physical_activity" ; rdfs:label "Physical Activity" ; a include:EnumDataCategory . include:EnumDataCategory.OTHER a owl:NamedIndividual ; skos:notation "other" ; rdfs:label "Other" ; a include:EnumDataCategory . include:EnumDataCategory.SLEEP_STUDY a owl:NamedIndividual ; skos:notation "sleep_study" ; rdfs:label "Sleep Study" ; a include:EnumDataCategory . include:EnumGuidType a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumGuidType.NDAR include:EnumGuidType.OTHER include:EnumGuidType.NO_GUID ) ] . include:EnumGuidType.NDAR a owl:NamedIndividual ; skos:notation "ndar" ; rdfs:label "NDAR" ; rdfs:comment "GUID generated by NIMH Data Archive (NDA) GUID tool" ; a include:EnumGuidType . include:EnumGuidType.OTHER a owl:NamedIndividual ; skos:notation "other" ; rdfs:label "Other" ; rdfs:comment "GUID generated by other system" ; a include:EnumGuidType . include:EnumGuidType.NO_GUID a owl:NamedIndividual ; skos:notation "no_guid" ; rdfs:label "No GUID" ; rdfs:comment "No GUIDs used in this study" ; a include:EnumGuidType . include:EnumConditionInterpretation a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumConditionInterpretation.OBSERVED include:EnumConditionInterpretation.NOT_OBSERVED ) ] . include:EnumConditionInterpretation.OBSERVED a owl:NamedIndividual ; skos:notation "observed" ; rdfs:label "Observed" ; rdfs:comment "Condition was observed or reported (this will be the case for most conditions)" ; a include:EnumConditionInterpretation . include:EnumConditionInterpretation.NOT_OBSERVED a owl:NamedIndividual ; skos:notation "not_observed" ; rdfs:label "Not Observed" ; rdfs:comment "Participant was specifically examined or medical record queried for condition and found to be negative" ; a include:EnumConditionInterpretation . include:EnumConditionDataSource a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumConditionDataSource.CLINICAL include:EnumConditionDataSource.SELF_REPORTED ) ] . include:EnumConditionDataSource.CLINICAL a owl:NamedIndividual ; skos:notation "clinical" ; rdfs:label "Clinical" ; rdfs:comment "Information about condition was obtained from medical records or reported by investigator" ; a include:EnumConditionDataSource . include:EnumConditionDataSource.SELF_REPORTED a owl:NamedIndividual ; skos:notation "self_reported" ; rdfs:label "Self-reported" ; rdfs:comment "Information about condition was reported by participant or family member" ; a include:EnumConditionDataSource . include:EnumConditionStatus a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumConditionStatus.CURRENT include:EnumConditionStatus.RESOLVED include:EnumConditionStatus.HISTORY_OF ) ] . include:EnumConditionStatus.CURRENT a owl:NamedIndividual ; skos:notation "current" ; rdfs:label "Current" ; rdfs:comment "Condition is ongoing" ; a include:EnumConditionStatus . include:EnumConditionStatus.RESOLVED a owl:NamedIndividual ; skos:notation "resolved" ; rdfs:label "Resolved" ; rdfs:comment "Condition has been resolved" ; a include:EnumConditionStatus . include:EnumConditionStatus.HISTORY_OF a owl:NamedIndividual ; skos:notation "history_of" ; rdfs:label "History Of" ; rdfs:comment "This is a general history of the condition, without known dates" ; a include:EnumConditionStatus . include:EnumDownSyndromeStatus a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumDownSyndromeStatus.D_21 MONDO:0008608 ) ] . include:EnumDownSyndromeStatus.D_21 a owl:NamedIndividual ; skos:notation "d21" ; rdfs:label "D21" ; rdfs:comment "Disomy 21 (euploid)" ; a include:EnumDownSyndromeStatus . MONDO:0008608 a owl:NamedIndividual ; skos:notation "t21" ; rdfs:label "T21" ; rdfs:comment "Trisomy 21 (Down syndrome)" ; a include:EnumDownSyndromeStatus . include:EnumEthnicity a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( NCIT:C17459 NCIT:C41222 NCIT:C132222 NCIT:C17998 ) ] . NCIT:C17459 a owl:NamedIndividual ; skos:notation "hispanic_or_latino" ; rdfs:label "Hispanic or Latino" ; a include:EnumEthnicity . NCIT:C41222 a owl:NamedIndividual ; skos:notation "not_hispanic_or_latino" ; rdfs:label "Not Hispanic or Latino" ; a include:EnumEthnicity . NCIT:C132222 a owl:NamedIndividual ; skos:notation "prefer_not_to_answer" ; rdfs:label "Prefer not to answer" ; a include:EnumEthnicity , include:EnumRace . NCIT:C17998 a owl:NamedIndividual ; skos:notation "unknown" ; rdfs:label "Unknown" ; skos:notation "unknown_or_not_available" ; rdfs:label "Unknown or not available" ; a include:EnumEthnicity , include:EnumRace , include:EnumSex , include:EnumVitalStatus . include:EnumFamilyRelationship a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( NCIT:C64435 NCIT:C25174 NCIT:C25189 NCIT:C25204 NCIT:C21480 NCIT:C25328 ) ] . NCIT:C64435 a owl:NamedIndividual ; skos:notation "proband" ; rdfs:label "Proband" ; rdfs:comment "The first affected family member to join the study" ; a include:EnumFamilyRelationship . NCIT:C25174 a owl:NamedIndividual ; skos:notation "father" ; rdfs:label "Father" ; a include:EnumFamilyRelationship . NCIT:C25189 a owl:NamedIndividual ; skos:notation "mother" ; rdfs:label "Mother" ; a include:EnumFamilyRelationship . NCIT:C25204 a owl:NamedIndividual ; skos:notation "sibling" ; rdfs:label "Sibling" ; a include:EnumFamilyRelationship . NCIT:C21480 a owl:NamedIndividual ; skos:notation "other_relative" ; rdfs:label "Other relative" ; a include:EnumFamilyRelationship . NCIT:C25328 a owl:NamedIndividual ; skos:notation "unrelated_control" ; rdfs:label "Unrelated control" ; a include:EnumFamilyRelationship . include:EnumFamilyType a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumFamilyType.CONTROL_ONLY include:EnumFamilyType.DUO include:EnumFamilyType.OTHER include:EnumFamilyType.PROBAND_ONLY include:EnumFamilyType.TRIO include:EnumFamilyType.TRIO_PLUS ) ] . include:EnumFamilyType.CONTROL_ONLY a owl:NamedIndividual ; skos:notation "control_only" ; rdfs:label "Control-only" ; rdfs:comment "Unrelated control, no Down syndrome family members" ; a include:EnumFamilyType . include:EnumFamilyType.DUO a owl:NamedIndividual ; skos:notation "duo" ; rdfs:label "Duo" ; rdfs:comment "Proband + one parent" ; a include:EnumFamilyType . include:EnumFamilyType.OTHER a owl:NamedIndividual ; skos:notation "other" ; rdfs:label "Other" ; rdfs:comment "Other family structure, e.g. one parent + twins" ; a include:EnumFamilyType . include:EnumFamilyType.PROBAND_ONLY a owl:NamedIndividual ; skos:notation "proband_only" ; rdfs:label "Proband-only" ; rdfs:comment "Proband only, no family members participating in study" ; a include:EnumFamilyType . include:EnumFamilyType.TRIO a owl:NamedIndividual ; skos:notation "trio" ; rdfs:label "Trio" ; rdfs:comment "Proband + two parents" ; a include:EnumFamilyType . include:EnumFamilyType.TRIO_PLUS a owl:NamedIndividual ; skos:notation "trio_plus" ; rdfs:label "Trio Plus" ; rdfs:comment "Proband + two parents + other relatives" ; a include:EnumFamilyType . include:EnumRace a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( NCIT:C41259 NCIT:C41260 NCIT:C16352 NCIT:C67109 NCIT:C41219 NCIT:C17649 NCIT:C41261 NCIT:C132222 NCIT:C17998 NCIT:C161419 NCIT:C126531 NCIT:C43866 NCIT:C41263 ) ] . NCIT:C41259 a owl:NamedIndividual ; skos:notation "american_indian_or_alaska_native" ; rdfs:label "American Indian or Alaska Native" ; a include:EnumRace . NCIT:C41260 a owl:NamedIndividual ; skos:notation "asian" ; rdfs:label "Asian" ; a include:EnumRace . NCIT:C16352 a owl:NamedIndividual ; skos:notation "black_or_african_american" ; rdfs:label "Black or African American" ; a include:EnumRace . NCIT:C67109 a owl:NamedIndividual ; skos:notation "more_than_one_race" ; rdfs:label "More than one race" ; a include:EnumRace . NCIT:C41219 a owl:NamedIndividual ; skos:notation "native_hawaiian_or_other_pacific_islander" ; rdfs:label "Native Hawaiian or Other Pacific Islander" ; a include:EnumRace . NCIT:C17649 a owl:NamedIndividual ; skos:notation "other" ; rdfs:label "Other" ; a include:EnumRace , include:EnumSex . NCIT:C41261 a owl:NamedIndividual ; skos:notation "white" ; rdfs:label "White" ; a include:EnumRace . NCIT:C161419 a owl:NamedIndividual ; skos:notation "east_asian" ; rdfs:label "East Asian" ; rdfs:comment "UK only; do not use for US data" ; a include:EnumRace . NCIT:C126531 a owl:NamedIndividual ; skos:notation "latin_american" ; rdfs:label "Latin American" ; rdfs:comment "UK only; do not use for US data" ; a include:EnumRace . NCIT:C43866 a owl:NamedIndividual ; skos:notation "middle_eastern_or_north_african" ; rdfs:label "Middle Eastern or North African" ; rdfs:comment "UK only; do not use for US data" ; a include:EnumRace . NCIT:C41263 a owl:NamedIndividual ; skos:notation "south_asian" ; rdfs:label "South Asian" ; rdfs:comment "UK only; do not use for US data" ; a include:EnumRace . include:EnumSex a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( NCIT:C16576 NCIT:C20197 NCIT:C17649 NCIT:C17998 ) ] . NCIT:C16576 a owl:NamedIndividual ; skos:notation "female" ; rdfs:label "Female" ; a include:EnumSex . NCIT:C20197 a owl:NamedIndividual ; skos:notation "male" ; rdfs:label "Male" ; a include:EnumSex . include:EnumVitalStatus a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( NCIT:C28554 NCIT:C37987 NCIT:C17998 ) ] . NCIT:C28554 a owl:NamedIndividual ; skos:notation "dead" ; rdfs:label "Dead" ; a include:EnumVitalStatus . NCIT:C37987 a owl:NamedIndividual ; skos:notation "alive" ; rdfs:label "Alive" ; a include:EnumVitalStatus . include:EnumDataAccess a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumDataAccess.CONTROLLED include:EnumDataAccess.OPEN include:EnumDataAccess.REGISTERED ) ] . include:EnumDataAccess.CONTROLLED a owl:NamedIndividual ; skos:notation "controlled" ; rdfs:label "Controlled" ; a include:EnumDataAccess . include:EnumDataAccess.OPEN a owl:NamedIndividual ; skos:notation "open" ; rdfs:label "Open" ; a include:EnumDataAccess . include:EnumDataAccess.REGISTERED a owl:NamedIndividual ; skos:notation "registered" ; rdfs:label "Registered" ; a include:EnumDataAccess . include:EnumAvailability a owl:Class ; owl:equivalentClass [ a owl:Class ; owl:oneOf ( include:EnumAvailability.AVAILABLE include:EnumAvailability.UNAVAILABLE ) ] . include:EnumAvailability.AVAILABLE a owl:NamedIndividual ; skos:notation "available" ; rdfs:label "Available" ; rdfs:comment "Sample or Container is potentially available to be requested through the Virtual Biorepository (see VBR contact info in Study page)" ; a include:EnumAvailability . include:EnumAvailability.UNAVAILABLE a owl:NamedIndividual ; skos:notation "unavailable" ; rdfs:label "Unavailable" ; rdfs:comment "Sample or Container either was available through Virtual Biorepository but has been used up, or is part of a study that is not participating in the VBR" ; a include:EnumAvailability . vann:preferredNamespacePrefix a owl:AnnotationProperty . vann:preferredNamespaceUri a owl:AnnotationProperty . skos:notation a owl:AnnotationProperty . sh:declare a owl:AnnotationProperty . sh:prefix a owl:AnnotationProperty . sh:namespace a owl:AnnotationProperty .